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Ittermann Till - - 2014
Thyroid dysfunction has been described to be linked to a variety of cardiovascular morbidities. Through this pathway thyroid function might also be associated with cardiorespiratory function and exercise capacity. So far only few patient-studies with small study populations investigated the association between thyroid dysfunction and exercise capacity. Thus, the aim ...
Makarova Julia A - - 2014
A large body of evidence indicates modified expression of protein-coding genes in response to different kinds of physical activity. Recent years have exposed another level of regulation of cellular processes mediated by non-coding RNAs. MicroRNAs (miRNAs) are one of the largest families of non-coding RNAs. MiRNAs mediate post-transcriptional regulation of ...
Brown Stephen J - - 2012
OBJECTIVES: Ventilation ( [Formula: see text] ) as a function of CO(2) output, and oxygen uptake ( [Formula: see text] ) as a function of [Formula: see text] , define cardio-respiratory efficiency, although few data compare efficiency with maximum oxygen uptake ( [Formula: see text] ), or consider reproducibility. Currently ...
Presti R Lo - - 2012
The purpose of this research was to evaluate the plasma protein carbonyl groups (PC) in 81 trained subjects (TS) who practiced regular, non professional physical activity. They were divided into three groups according to the type of sport they practiced (endurance, mixed or power). On fasting venous blood we examined ...
Moore Graham F - - 2011
Background: Though motivational interviewing (MI) has demonstrated efficacy in a range of behaviour change settings, effectiveness will require successful integration into everyday practice. This study examines implementers' views on delivering MI within an exercise referral scheme and consistency of consultations with MI before and after a 2-day workshop. Method: Semi-structured ...
Veerabhadrappa Shashikala G - - 2011
Yoga is an ancient science, which originated in India. Pranayama has been assigned a very important role in yogic system of exercises. It is known that regular practice of breathing exercises (pranayama) increases parasympathetic tone, decreases sympathetic activity, and improves cardiovascular functions. Different types of breathing exercises alter autonomic balance ...
Oftedal Bjørg - - 2011
Scand J Caring Sci Motivation for diet and exercise management among adults with type 2 diabetes Aim:  The aim of this study was to investigate diet and exercise management and how indicators of intrinsic motivation such as ability expectations and values are associated with diet and exercise management among adults ...
Tsai Han Hui - - 2011
The aim of this study is to develop a practicable worksite physical fitness program for small and medium-sized enterprises (SMEs). Community-based intervention consisting of a three-month exercise course was conducted, and its benefits evaluated. A self-administrated structured questionnaire and physical fitness examination were designed to compare the difference between pre ...
Resnick Barbara - - 2011
The objectives of this study were to test a model of the factors that influence exercise activities among a group of older adults living in a continuing care retirement community with a wellness center that features a pool, exercise room, and exercise classes. This was a correlational study using a ...
Cowie Aynsley - - 2011
Background: In heart failure, reduced physical activity level can adversely affect physical and psychosocial functioning. No previous heart failure research has compared effects of home and hospital-based exercise training upon physical activity level, or has objectively assessed their long-term effects upon physical activity. This study used an activPAL(™) monitor to ...
Chen Kuei-Min - - 2011
Aims.  To evaluate and compare the appropriateness of the Silver Yoga exercise programme for community and institutional elders and to determine their preferences towards yoga exercises. Background.  Yoga has been used to promote the health of elders. The Silver Yoga was developed to accommodate the physical tolerance and body flexibility ...
Evett Jonathan - - 2011
In this paper, collective corporate resilience is studied to see how a culture of sharing information and planning may assist other business communities to prepare for future events. The London 2012 Summer Olympic Games will see huge opportunity for businesses in London, and across Europe, but not without cost. Canary ...
Dunsford Angela - - 2011
Low back pain (LBP) is a major health issue with significant socioeconomic implications in most Western countries. Many forms of treatment have been proposed and investigated in the past, with exercise being a commonly prescribed intervention. Within allied health, in particular physiotherapy, there has been a growing movement that recognizes ...
Prakash Ashwin A Children's Hospital Boston, Boston, Massachusetts, USA. - - 2010
The effects of the nondominant or secondary ventricle on the Fontan circulation are not known. The present study used cardiac magnetic resonance imaging to investigate the relations between secondary ventricular size and global cardiac performance. The Fontan cross-sectional study collected data from 7 centers participating in the Pediatric Heart Network. ...
Hodges Gary J - - 2010
This study tested the hypothesis that prolonged physical deconditioning affects the coupling of left ventricular depolarization to its ejection (the pre-ejection period, PEPi) and that this effect is minimized by exercise countermeasures. Following assignment to non-exercise (Control) and exercise groups (Exercise), 14 females performed 56 days of continuous head-down tilt ...
Abozguia Khalid K School of Medicine and Dentistry, University of Aberdeen, Aberdeen, - - 2010
Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and thereby improve diastolic function and exercise capacity. Forty-six consecutive patients with symptomatic exercise limitation ...
Berger Thomas - - 2011
Cardiac resynchronization therapy (CRT) is limited by the high numbers of nonresponders. This study analyzed the impact of the cardiorespiratory functional reserve to predict the response to CRT. Twenty-eight patients (age 67 ± 9 years, LVEF < 35%, NYHA class III, QRS 158 ± 25 ms) underwent submaximal cardiopulmonary treadmill exercise testing prior and 6 months after implantation of ...
Kitzman Dalane W DW Cardiology Section, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA. - - 2010
Heart failure (HF) with preserved left ventricular ejection fraction (HFPEF) is the most common form of HF in the older population. Exercise intolerance is the primary chronic symptom in patients with HFPEF and is a strong determinant of their reduced quality of life (QOL). Exercise training (ET) improves exercise intolerance ...
Maeder Micha T - - 2010
OBJECTIVES: The purpose of this study was to invasively investigate the hemodynamic response to exercise in patients with heart failure with normal ejection fraction (HFNEF) and to evaluate the ability of the peak early diastolic transmitral velocity to peak early diastolic annular velocity ratio (E/e') to reflect exercise hemodynamics. BACKGROUND: ...
Tan Y T - - 2010
The cardinal symptom of heart failure with a normal ejection fraction (HFNEF) is exertional dyspnoea. The authors hypothesised that failure of left atrial (LA) compensatory mechanism particularly on exercise contributes to the genesis of symptoms in HFNEF patients. Fifty HFNEF patients, 15 asymptomatic hypertensive subjects and 30 healthy controls underwent ...
Weiss Robert M RM University of Iowa Hospitals and Clinics, Division of Cardiovascular Medicine, Department of Internal Medicine, 200 Hawkins Drive, Room E317-1 GH, Iowa City, IA 52242, USA. - - 2010
Mutations in the X-linked gene encoding dystrophin cause skeletal and cardiac muscle diseases in men. Female "carriers" also can develop overt disease. The purpose of this study was to ascertain the prevalence of cardiac contractile abnormalities in dystrophinopathy carriers. Twenty-four dystrophinopathy heterozygotes and 24 normal women each underwent standard exercise ...
Borlaug Barry A BA Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn 55905, USA. - - 2010
When advanced, heart failure with preserved ejection fraction (HFpEF) is readily apparent. However, diagnosis of earlier disease may be challenging because exertional dyspnea is not specific for heart failure, and biomarkers and hemodynamic indicators of volume overload may be absent at rest. Patients with exertional dyspnea and ejection fraction >50% ...
Jellis Christine L - - 2010
Limitations in the predictive value of negative exercise echocardiography in type 2 diabetes mellitus has been linked to a reduced end-systolic pressure-volume response (ESPVR). We sought whether abnormal ESPVR reflected subclinical diabetic heart disease by examining the association between the ESPVR and markers of myocardial dysfunction and to establish if ...
Yoshino Tomohide - - 2010
OBJECTIVE: Echocardiographic studies have suggested an association between diastolic dysfunction and exercise intolerance. The aim of this study was to examine the relationship between exercise capacity and left ventricular (LV) function during stress myocardial scintigraphy, and to investigate whether or not this relationship is caused by ischemia during exercise. METHODS: ...
Abozguia Khalid - - 2010
Nonobstructive hypertrophic cardiomyopathy (nHCM) is often associated with reduced exercise capacity despite hyperdynamic systolic function as measured by left ventricular ejection fraction. We sought to examine the importance of left ventricular strain, twist, and untwist as predictors of exercise capacity in nHCM patients. Fifty-six nHCM patients (31 male and mean ...
Chen June-Kai - - 2010
The purpose of this study was to evaluate the feasibility and exercise capacity of cycle ergometry exercise testing and exercise performance in patients with post-acute stroke. Nineteen male patients (mean age, 62.7 +/- 9.2 years) with a post stroke interval of 9.9 +/- 2.0 days underwent symptom- limited cardiopulmonary exercise ...
Steeden Jennifer A JA Centre for Medical Image Computing, UCL Department of Medical Physics & Bioengineering, London, United - - 2010
To measure the hemodynamic response to exercise using real-time velocity mapping magnetic resonance imaging (MRI), incorporating a high temporal resolution spiral phase contrast (PC) sequence accelerated with sensitivity encoding (SENSE). Twenty healthy adults underwent MRI at rest and during supine exercise at two different exercise levels. Flow volumes were assessed ...
Bringard Aurélien - - 2010
We tested the hypothesis that, after bed rest, maximal oxygen consumption ( VO₂max ) decreases more upright than supine, because of adequate cardiovascular response supine, but not upright. On 9 subjects, we determined VO₂max and maximal cardiac output (Q ) upright and supine, before and after (reambulation day upright, the ...
Harrild David M DM Departments of Cardiology, Children's Hospital Boston, and Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. - - 2010
This study sought to examine the prevalence and predictors of pulmonary regurgitation (PR) following balloon dilation (BD) for pulmonary stenosis (PS) and to investigate its impact on ventricular volume and function, and exercise tolerance. Balloon pulmonary valvuloplasty relieves PS but can cause late PR. The sequelae of isolated PR are ...
Liang Xue-Cun - - 2010
BACKGROUND: The hypertrophic myocardium, myocardial fiber disarray, and endocardial fibroelastosis in pulmonary atresia and intact ventricular septum (PAIVS) may provide anatomic substrates for restrictive filling of the right ventricle. HYPOTHESIS: Restrictive right ventricle (RV) physiology is related to RV fibrosis and exercise capacity in patients after biventricular repair of PAIVS. ...
Armstrong David W J - - 2010
To determine the normal range of estimated right ventricular systolic pressure (RVSP) at peak exercise during exercise stress echocardiography (ExECHO) in a series of consecutive patients referred for the investigation of coronary artery disease. Of 1057 ExECHO examinations over a span of 11 months, 807 met the study criteria. A ...
Le Vy-Van - - 2010
BACKGROUND: Premature ventricular contractions (PVC) at rest are frequently seen in heart failure (HF) patients but conflicting data exist regarding their importance for cardiovascular (CV) mortality. This study aims to evaluate the prognostic value of rest PVCs on an electrocardiogram (ECG) in patients with a history of clinical HF. METHODS ...
Plehn Gunnar - - 2010
Although the biventricular nature of the disease has been confirmed by morphologic studies, information on right ventricular (RV) function in hypertrophic cardiomyopathy (HC) is lacking. The aim of the study was to hemodynamically characterize RV performance in HC versus idiopathic dilated cardiomyopathy (IDC) during exercise. The hemodynamic data of 63 ...
Wong Raymond C - - 2010
The purpose of this study was to examine the relationship between noninvasive measurements of ventricular-vascular coupling (VVC) with exercise tolerance, and compared the value of VVC versus other traditional determinants of exercise capacity in this population. 43 patients with ischemic CMP (age 59 +/- 9 years, mean EF 24 +/- ...
Plehn Gunnar - - 2009
INTRODUCTION: It is not clear whether in patients with the clinical suspicion of heart failure with normal ejection fraction (HFNEF) exercise assessment of diastolic function may help to unmask abnormalities not detected by resting measurements. METHODS AND RESULTS: A combined radionuclide angiographic and haemodynamic exercise study was performed to confirm ...
Atchley Allen E - - 2009
There are currently limited data on the relationships between resting perfusion abnormalities, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, and exercise capacity as defined by peak VO(2) and 6-minute walk test in patients with heart failure (HF) and reduced LVEF. Furthermore, the association between resting ...
Stevens Gerin R - - 2009
BACKGROUND: The 6-minute walk distance (6MWD) is a useful measure of functional class and has been shown to predict mortality in patients with pulmonary hypertension (PH). Determinants of functional class in PH are incompletely understood. We hypothesized that cardiovascular structure and function, as determined by cardiac magnetic resonance (CMR) imaging, ...
Turakhia Mintu P - - 2009
The predictive value of changes in global left ventricular (LV) size after exercise has not been studied. Left ventricular end-systolic volume (ESV) is a relatively load-independent echocardiographic marker of contractility that is easily measured. We investigated the role of the change in ESV at rest and after peak exercise on ...
Tan Yu Ting - - 2009
OBJECTIVES: The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, delayed untwisting, and impaired early diastolic filling. BACKGROUND: ...
Di Salvo Giovanni - - 2010
Because transposition of great arteries (TGA) patients who underwent atrial switch repair (AS) remain asymptomatic for decades before development of symptomatic heart failure, there may be some clinical value to preclinical detection of ventricular dysfunction. Detection of systemic right ventricular (RV) dysfunction in patients who are asymptomatic may prompt early ...
Storto G - - 2009
BACKGROUND: Reduced systolic reserve on effort may be present in subjects with hypertension but no evidence of hypertensive cardiomyopathy. We assessed the determinants of abnormal cardiac performance during exercise in hypertensive patients without left ventricular hypertrophy. MATERIALS AND METHODS: Thirty-five newly diagnosed, never-treated-earlier hypertensive patients without definite indication for left ...
Wald Rachel M - - 2009
BACKGROUND: The underlying mechanisms that contribute to global right ventricular (RV) dysfunction in patients with repaired tetralogy of Fallot are incompletely understood. We therefore sought to quantify regional RV abnormalities and to determine the relationship of these to global RV function and exercise capacity. METHODS AND RESULTS: Clinical and cardiac ...
Choi Su-Yeon - - 2009
The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using ...
Silva-Tinoco Rubén - - 2009
BACKGROUND: The aim of this study was to assess the effect of left ventricular dysfunction on right ventricular ejection fraction during exercise in heart failure patients and its implications in functional capacity and blood pressure response. METHODS: In a cross-sectional study 65 patients with heart failure were included. Left and ...
Okamatsu Kyoko - - 2009
BACKGROUND: Aging affects left atrial (LA) function, which can be assessed by two-dimensional (2D) speckle tracking echocardiography (STE). The aim of this study was to determine (1) the feasibility and accuracy of measuring LA volume with 2DSTE and (2) the effects of aging on LA function. METHODS: 2DSTE of the ...
Haigney Mark C - - 2009
BACKGROUND: Increased QT Variability (QTVI) is predictive of life threatening arrhythmias in vulnerable patients. The predictive value of QTVI is based on resting ECGs, and little is known about the effect of acute exercise on QTVI. The relation between QTVI and arrhythmic vulnerability markers such as T-wave alternans (TWA) has ...
Spinelli L - - 2008
BACKGROUND: Fatigability and dyspnoea on effort are present in many patients with Fabry's disease. We assessed the determinants of cardiac performance during exercise in patients with Fabry's disease and preserved left ventricular ejection fraction at rest. MATERIALS AND METHODS: Sixteen patients with Fabry's disease and 16 control subjects underwent radionuclide ...
Argyropoulos George - - 2009
A genome-wide linkage scan for endurance training-induced changes in stroke volume detected a quantitative trait locus on chromosome 10p11 in white families of the HERITAGE Family Study. Dense microsatellite mapping narrowed down the linkage region to a 7 Mb area containing 16 known and 14 predicted genes. Association analyses with ...
Sodhi Jaswinder Singh - - 2008
BACKGROUND: Recumbency and bending are thought to provoke symptoms of reflux in patients with gastroesophageal reflux disease (GERD). The effect of exercise which involved bending and abdominal contractions was evaluated in symptomatic patients of GERD using continuous 24-hour ambulatory esophageal pH test. METHODS: Twenty-five patients with GERD, confirmed by abnormal ...
Otsuki Takeshi - - 2008
Systemic arterial compliance (C) and vascular resistance (R) regulate effective arterial elastance (Ea), an index of artery load. Increases in Ea during exercise are due primarily to reductions of C and maintain optimal ventricular-arterial coupling. Because C at rest and left ventricular functional reserve are greater in endurance-trained (ET) compared ...
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