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Ritchie Ian R W IR Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, - - 2014
Adiponectin (Ad) is a potent insulin-sensitizing adipokine that has been found to activate pathways involved in the adaptation to exercise. Therefore, we examined whether Ad is required for the increased insulin response observed following exercise training in Ad knockout mice (AdKO). Eight weeks of exercise training significantly increased glucose and ...
Knudsen Sine H SH Department of Infectious Diseases, The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
We investigated glucose tolerance and postprandial glucose fluxes immediately after a single bout of aerobic exercise in subjects representing the entire glucose tolerance continuum. Twenty-four men with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes (T2D; age: 56 ± 1 years; body mass index: 27.8 ± ...
Blankenship Jennifer M JM Energy Metabolism Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, - - 2014
Recent evidence suggests that, like adding exercise, reducing sitting time may improve cardiometabolic health. There has not been a direct comparison of the 2 strategies with energy expenditure held constant. The purpose of this study was to compare fasting and postmeal glucose and insulin concentrations in response to a day ...
Skou Søren Thorgaard ST Orthopaedic Surgery Research Unit, Aalborg University Hospital, Research and Innovation Center, 15 Soendre Skovvej, 9000 Aalborg, Denmark. - - 2014
Education and exercise are poorly implemented in osteoarthritis care. The purpose of the present study was to identify predictors of effectiveness at one year from education and exercise in patients with knee or hip pain in clinical practice. Good Life with Arthritis in Denmark is an implementation initiative consisting of ...
Hao Zhe Z Department of Sports Anatomy, School of Sports Science, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, - - 2014
The objective of this study was to investigate the late cardiac effect of exercise preconditioning (EP) on the exhaustive exercise-induced myocardial injury in rats and the role of protein kinase C (PKC) in EP. Rats were subjected to a run on the treadmill for four periods of 10 min each at ...
Sinaei M M Department of Physical Education and Sport Sciences. Islamic Azad University Khorasgan, Arghavaniye, Isfahan, Iran. - - - 2014
The aim of this study was to compare BMI and the effects of a session of acute exercise on serum beta-endorphin levels among the sprint swimmers and runners. In a semi-experimental study, 15 healthy skilled male swimmers (mean and SD of age: 21.64 ± 2.35, Weight: 75.25 ± 9.81 kg, ...
Koseoglu E E Erciyes University, Faculty of Medicine, Neurology Department, Kayseri, Turkey - - - 2014
This review aims to provide a comprehensive overview of the literature on the use of exercise for migraine treatment with regard to its efficacy, mechanism of action and role in practice. Many randomised studies have reported the efficacy of prophylactic treatment of migrane with medications such as beta blockers or ...
Gross Micah M Institute for Anatomy, University of Bern, - - 2014
Supplementation with beta-alanine may have positive effects on severe-intensity, intermittent and isometric strength-endurance performance. These could be advantageous for competitive alpine skiers, whose races last 45 - 150 seconds, require metabolic power above the aerobic maximum and involve isometric muscle work. Further, beta-alanine supplementation affects the muscle force-frequency relationship, which ...
Bennett Matthew T MT Division of Cardiology, Department of Medicine, University of British Columbia, Arrhythmia Service, 9th Floor, Gordon & Leslie Diamond Health Care Centre, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9 - - 2014
Beta-blockers are the standard of care for the treatment of long QT syndrome (LQTS), and have been shown to reduce recurrent syncope and mortality in patients with type 1 LQTS (LQT1). Although beta-blockers have minimal effect on the resting corrected QT interval, their effect on the dynamics of the non-corrected ...
Hao Zhe Z Department of Sports Anatomy, School of Sports Science, Shanghai University of - - 2014
Background: Exercise preconditioning (EP) can provide powerful protection to the heart. Evidence supports the contention that EP directly enhances myocardial tolerance to ischaemia through a protein kinase C (PKC)-mediated mechanism. However, studies investigating the role of isoform-specific PKC after EP are lacking. Methods and Results: In this study, a male Sprague-Dawley rat ...
Sun Xiao-Juan XJ 1Department of Physical Education, Xianyang Normal University, Xianyang, China 2Department of Sports Anatomy, School of Sports Science, Shanghai University of Sport, Shanghai, - - 2014
to examine the role of calcitonin gene-related peptide (CGRP) in cardioprotection of short-term and long-term exercise preconditioning (EP). Male Sprague-Dawley rats were respectively subjected to continuous intermittent treadmill training 3 days or 3 weeks as short-term or long-term EP protocols. The myocardial injury induced by Isoproterenol (ISO) was performed 24h ...
Deftereos Spyridon S Department of Cardiology, Athens General Hospital "G. Gennimatas", Athens, Greece; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, - - 2014
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide production. The purpose of this study was to assess the correlation between ADMA and treadmill stress test outcome parameters with known prognostic value, in patients with intermediate risk for coronary artery disease (CAD). Study participants were referred for treadmill exercise ...
Kim Bo-Kyun BK Department of Physiology, College of Medicine, Kyung Hee University, Seoul, - - 2014
Alzheimer's disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impairment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present ...
Chung Weiliang W Department of Movement and Sports Sciences, Ghent University, Ghent, - - 2014
Muscle carnosine loading through chronic oral beta-alanine supplementation has been shown to be effective for short-duration, high-intensity exercise. This randomised, placebo controlled study explored whether the ergogenic effect of beta-alanine supplementation is also present for longer duration exercise. Subjects (27 well-trained cyclists/triathletes) were supplemented with either beta-alanine or placebo (6.4 ...
Douw Linda L Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands ; Department of Anatomy and Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The - - 2014
A healthy lifestyle is an important focus in today's society. The physical benefits of regular exercise are abundantly clear, but physical fitness is also associated with better cognitive performance. How these two factors together relate to characteristics of the brain is still incompletely understood. By applying mathematical concepts from 'network ...
Kudoh Yasuo Y Kidney Center, Sapporo South One Hospital, Sapporo, - - 2014
It is well known that the physical activity in chronic hemodialysis patients decreases compared to that in normal subjects. In order to investigate the effects of L-carnitine on physical capacity and lipid metabolism, a cardiopulmonary exercise test using a bicycle ergometer was performed before and after 3 months of oral ...
Matoulek M M Third Internal Medicine Clinic, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. - - 2014
The aim was to find the differences in ketogenesis initiation in the early period after the exercise in obese patients and to find if these changes may predict the weight loss during the physical activity program. 96 females were enrolled. A clamped heart rate test (CHR) was performed to establish ...
Gómez-Gómez Eduardo E Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, - - 2014
Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified as indicators of obesity in population studies. It is therefore important ...
Kuehnbaum Naomi L NL Department of Chemistry and Chemical Biology, McMaster University, Hamilton, - - 2014
High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear. Herein, multi-segment injection capillary electrophoresis-mass spectrometry is used as a high-throughput platform in metabolomics to assess dynamic responses of overweight/obese women (BMI > 25, ...
Smith-Ryan Abbie E - - 2013
Beta-alanine (BA) supplementation has been shown to delay neuromuscular fatigue as a result of increased muscle carnosine concentrations. Carnosine has also been found in brain and cardiac tissue. The physical working capacity test at heart rate threshold (PWCHRT ) is a global estimate of the onset of fatigue during exercise, ...
Antunes Ana Patrícia - - 2013
Deficiency of very-long-chain acyl-CoA dehydrogenase (VLCAD) is an autosomal recessive disease. Most common phenotypes occur in the neonatal period or in childhood with cardiomyopathy, hepatomegaly, and hypoketogenic hypoglycemia. Juvenile/adult-onset is characterized by exercise intolerance and recurrent rhabdomyolysis triggered by prolonged exercise or fasting. This article reports a patient with the ...
Gamze Erikoglu Orer - - 2013
This study examined the effect of acute L-carnitine loading on the endurance performance of footballers.Measurements were performed on 26 candidate professional footballers who volunteered to take part in the study. Athletes were given a glass of fruit juice one hour before applying L-carnitine with the double blind method. Then 12 ...
Gross Micah - - 2013
We aimed to manipulate physiological determinants of severe exercise performance. We hypothesized that (1) beta-alanine supplementation would increase intramuscular carnosine and buffering capacity and dampen acidosis during severe cycling, (2) that high-intensity interval training (HIT) would enhance aerobic energy contribution during severe cycling, and (3) that HIT preceded by beta-alanine ...
Lin Zhong - - 2013
Traditional Chinese eye exercises of acupoints involve acupoint self-massage. These have been advocated as a compulsory measure to reduce ocular fatigue, as well as to retard the development of myopia, among Chinese school children. This study evaluated the impact of these eye exercises among Chinese urban children. 409 children (195 ...
Vogt Tobias - - 2013
Artificial gravity (AG) exposure is suggested to counteract health deconditioning, theoretically complementing exercise during space habitations. Exercise-benefits on mental health are well documented (i.e. well-being, enhanced executive functions). Although AG is coherent for the integrity of fundamental physiological systems, the effects of its exposure on neurophysiological processes related to cognitive ...
Münzel Thomas - - 2013
The organic nitrate pentaerithrityl tetranitrate (PETN) has been shown to have ancillary properties that prevent the development of tolerance and endothelial dysfunction. This randomized, double-blind, placebo-controlled, multicentre study ('CLEOPATRA' study) was designed to investigate the anti-ischaemic efficacy of PETN 80 mg b.i.d. (morning and mid-day) over placebo in patients with ...
Molfino Alessio - - 2013
Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the branched-chain amino acid leucine, is extensively used by athletes and bodybuilders in order to increase strength, muscle mass and exercise performance. We performed a systematic review of the clinical literature on the effectiveness of HMB supplementation in healthy and pathological conditions (i.e. training programs, ...
Gamze Erikoglu Orer - - 2013
This study examined the effect of acute L-carnitine loading on the endurance performance of footballers.Measurements were performed on 26 candidate professional footballers who volunteered to take part in the study. Athletes were given a glass of fruit juice one hour before applying L-carnitine with the double blind method. Then 12 ...
Borisut Sudarat S Faculty of Physical Therapy, Mahidol - - 2013
[Purpose] To compare muscle activities and pain levels of females with chronic neck pain receiving different exercise programs. [Subjects and Methods] One hundred females with chronic neck pain participated in this study. They were randomly allocated into 4 groups (n = 25) on the basis of the exercises performed as ...
Khoury Asaad - - 2013
Calsequestrin (CASQ2) associated Catecholaminergic polymorphic ventricular tachycardia (CPVT2) can cause sudden death in young individuals in response to stress. Beta blockers are the mainstay medical treatment for CPVT2 patients. However, they do not prevent syncope and sudden death in all patients. Flecainide was reported to reduce exercise-induced ventricular arrhythmias (EIVA) ...
Alemo Munters Li - - 2013
This randomized, controlled study on patients with polymyositis or dermatomyositis was based on three hypotheses: Patients display impaired endurance due to reduced aerobic capacity and muscle weakness, endurance training improves their exercise performance by increasing the aerobic capacity, and endurance training has general beneficial effects on their health status. In ...
Díaz-Buschmann Isabel - - 2013
To verify the usefulness of current recommended level of target exercise heart rate (HR) and of different HR-based methods for calculating target HR in patients with and without beta-blocker treatment. We studied 53 patients not treated with beta-blocker and 159 patients on beta-blocker treatment. All patients underwent a maximal exercise ...
Martins Lilian Cristina - - 2013
Physical fitness is one of the most important qualities in armed forces personnel. However, little is known about the association between the military environment and the occupational and leisure-time dimensions of the physical activity practiced there. This study assessed the association of rank, job stress and psychological distress with physical ...
Fachko Michael J - - 2013
The purpose of this study was to quantify the cardiovascular responses and enjoyment of one trial of electronic exercise gaming (EG) (Nintendo(®) Wii(™) Tennis) in healthy, older adults (mean age = 81 [SD = 4 years]). Findings indicate that 15 minutes of EG moderately increased heart rate (p < 0.001), ...
Bowen Rudy - - 2013
Building on previous work indicating that mood instability is the hallmark of neuroticism, our aim was to examine whether changes in exercise, sleep duration, and leisure predicted decreases in mood instability with time. We used data from 3,374 participants of the British Health and Lifestyle Study who answered the Eysenck ...
Brownsberger J - - 2013
The purpose of this study was to examine whether mental fatigue influences the perceived effort required to complete fairly light and hard effort self-paced exercise challenges. 12 participants completed 2 trials in a randomised cross-over design. Each participant was required to complete a time-matched pre-exercise task: 1) a continuous cognitive ...
Hogan Michael - - 2013
The current study examined the effects of physical fitness and aerobic exercise on cognitive functioning and coherence of the electroencephalogram in 30 adolescents between the ages of 13 and 14 years. Participants were first classified as fit or unfit and then performed a modified Eriksen flanker task after a bout of ...
Laksman Zachary W M - - 2013
BACKGROUND: Targeted mutation site-specific differences have correlated C-loop missense mutations with worse outcomes and increased benefit of beta-blockers in LQT1. This observation has implicated the C-loop region as being mechanistically important in the altered response to sympathetic stimulation known to put patients with LQT1 at risk of syncope and sudden ...
Vissing Christoffer Rasmus - - 2013
Mitochondrial myopathies commonly present with exercise intolerance typified by breathlessness and fatigue on exercise. In contrast, exercise-induced rhabdomyolysis and myoglobinuria occur rarely. We present a 43-year-old man with a lifelong history of exercise intolerance associated with myalgia and recurrent episodes of exercise-induced myoglobinuria. From early childhood, he had weekly episodes ...
Dufay-Bougon Clémentine - - 2013
Objectives: The prevalence of chronic heart failure and a reduced ejection fraction (CHF-REF) has increased over the last decade. The cardiopulmonary exercise test (CPET) is an established tool for managing these patients. For patients who are administered beta-blockers, its predictive value is debated. The aim of this study was to ...
Madsen K L - - 2013
Background:It is not clear to what extent skeletal muscle is affected in patients with medium-chain acyl-coenzyme A dehydrogenase deficiency (MCADD). l-Carnitine is commonly used as a supplement in patients with MCADD, although its beneficial effect has not been verified.Design:We investigated (1) fuel utilization during prolonged low-intensity exercise in patients with ...
Souza Leandro C - - 2013
This study was designed to investigate the potential neuroprotective effect of exercise in a mouse model of Alzheimer's disease (AD) induced by intracerebroventricular (i.c.v.) injection of beta-amyloid(1-40) (Aβ(1-40)) peptide. For this aim, male Swiss Albino mice were submitted to swimming training (ST) with progressive increase in intensity and duration for ...
Wilson Jacob M - - 2013
Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature on the use of beta-hydroxy-beta-methylbutyrate (HMB) as a nutritional supplement. The ISSN has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal ...
Stephens Francis B - - 2013
Fat and carbohydrate are the primary fuel sources for mitochondrial ATP production in human skeletal muscle during endurance exercise. However, fat exhibits a relatively low maximal rate of oxidation in vivo, which begins to decline at around 65% of maximal oxygen consumption (VO2max) when muscle glycogen becomes the major fuel. ...
Fritz Thomas H TH Max Planck Institute for Human Cognitive and Brain Science Leipzig, Germany ; Institute for Psychoacoustics and Electronic Music Gent, Belgium ; Department of Nuclear Medicine, University of Leipzig Leipzig, - - 2013
Music making has a number of beneficial effects for motor tasks compared to passive music listening. Given that recent research suggests that high energy musical activities elevate positive affect more strongly than low energy musical activities, we here investigated a recent method that combined music making with systematically increasing physiological ...
Lascar Nadia N Clinical and Experimental Medicine, University of Birmingham, Birmingham, - - 2013
Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise has not been examined in type 1 diabetes. Significant beta cell function is present at the time of diagnosis of type 1 diabetes and therefore studies of beta cell preservation are ideally conducted ...
Ducker Kagan J - - 2012
Beta-alanine supplementation has been shown to improve exercise performance in short-term high-intensity efforts. However, whether supplementation with beta-alanine is ergogenic to actual sporting events remains unclear and should be investigated in field testing or race simulations. PURPOSE: The aim of this study was to assess if beta-alanine supplementation could improve ...
Hiramoto Keiichi - - 2013
This study investigated the mechanism by which the strength and weakness of exercise stress affects the skin symptoms of atopic dermatitis (AD). Specific pathogen-free (SPF) and conventional NC/Nga mice were used. Conventional mice, but not the SPF, spontaneously develop dermal symptoms similar to that of patients with AD. There were ...
Dekleva Milica M School of Medicine University of Belgrade, University Clinical Centre Zvezdara Belgrade, Serbia. - - 2012
Exercise capacity is critical for therapy and prognosis in patients with heart failure (HF). Effect of beta-blockers (BB) on exercise capacity in elderly patients with HF remains unclear. To assess contribution of BB to functional capacity and left ventricular (LV) function in the elderly with HF. According to the protocol ...
Tardif Jean-Claude - - 2012
BACKGROUND: Any increase in heart rate (HR) during daily activities above the ischemic threshold may trigger myocardial ischemia. HR reduction with the I(f) inhibitor ivabradine has been demonstrated to confer anti-ischemic and antianginal efficacy in patients with stable angina pectoris. This analysis of the ASSOCIATE trial assessed whether the anti-ischemic ...
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