Search Results
Results 1 - 50 of 1164
1 2 3 4 5 6 7 8 9 10 >
Hansen Merethe M Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark - - 2014
We investigated the role of metformin on glucose kinetics during moderate exercise. Before, during, and after a 45-min bout of exercise at 60% VO2max, glucose kinetics were determined by isotope tracer technique in patients with type 2 diabetes mellitus with metformin treatment (DM2+Met) or without metformin treatment (DM2) and in ...
Stanford Kristin I KI Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts - - 2014
Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal muscle are essential for this improvement. An acute bout of exercise increases skeletal muscle glucose uptake, while chronic exercise training improves mitochondrial ...
Lumb Alistair A Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford, UK - - 2014
Exercise has a beneficial effect on metabolic parameters affecting cardiovascular risk, such as lipids and blood glucose, and is a key component in both the prevention and the management of type 2 diabetes. Glycaemic control improves with both aerobic and resistance exercise in type 2 diabetes, but no glycaemic benefit ...
Greenberg Barry H BH University of California at San Diego, San Diego, California. Electronic address: - - 2014
The goal of this study was to assess the safety and tolerability of omecamtiv mecarbil treatment during symptom-limited exercise in patients with ischemic cardiomyopathy and angina. These patients may have increased vulnerability to prolongation of the systolic ejection time. Omecamtiv mecarbil is a selective cardiac myosin activator that augments cardiac ...
Fofonka Aline - - 2014
Cardiovascular disease, endothelial dysfunction, and oxidative stress are common complications among patients with type 2 diabetes (T2DM). In addition to the average blood glucose concentration, glycemic variability may be an important factor for the development of chronic diabetes complications. Patients with T2DM are treated with various types of oral glucose-lowering ...
Chatzisarantis Nikos L D NL School of Psychology and Speech Pathology, Curtin University, Perth, Australia. Electronic address: - - 2014
The purpose of the present article is to highlight limitations of Lange and Eggert's methodology of using identical self-control tasks in testing effects of glucose on depletion of self-control resources and self-control performance. We suggest that when participants engage in two identical self-control tasks, cognitions developed during initial act of ...
Wiles Louise L School of Health Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, - - 2014
Previous systematic reviews have confirmed the benefits of both exercise training and psychological interventions in people with chronic obstructive pulmonary disease (COPD). The objective of this systematic review was to examine the effect of interventions which combine exercise training and psychological interventions for a range of health outcomes in people ...
Preisler Nicolai N Neuromuscular Research Unit, Section 3342, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark, - - 2014
Glycogen storage diseases (GSD) are inborn errors of glycogen or glucose metabolism. In the GSDs that affect muscle, the consequence of a block in skeletal muscle glycogen breakdown or glucose use, is an impairment of muscular performance and exercise intolerance, owing to 1) an increase in glycogen storage that disrupts ...
Cockcroft Emma J EJ Children's Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, - - 2014
High-intensity interval exercise (HIIE) may offer a time efficient means to improve health outcomes compared to moderate-intensity exercise (MIE). This study examined the acute effect of HIIE compared to a work-matched bout of MIE on glucose tolerance, insulin sensitivity (IS), resting fat oxidation and exercise enjoyment in adolescent boys. Within-measures ...
Jastrzębski D D School of Medicine with the Division of Dentistry, Department of Lung Diseases and Tuberculosis, Medical University of Silesia, 41-803, 1 Koziolka St., Zabrze, Poland, - - 2014
Fatigue is one of the major symptoms reported by sarcoidosis patients. The relationship between fatigue and clinical course of sarcoidosis remains unclear. The aim of the study was to evaluate the relationship between fatigue and lung function tests, exercise tolerance, dyspnea, and quality of life among sarcoidosis patients. One hundred ...
Johnson Miriam J MJ Hull York Medical School, The University of Hull, Hull, United Kingdom - - 2014
The aim of this paper is to review the evidence for a role for opioids as an intervention for exertion induced breathlessness with regard to exercise tolerance and breathlessness intensity. Current knowledge about exogenous opioids in exertion-induced breathlessness due to disease comes from a variety of phase 2 feasibility or ...
Cartee Gregory D GD Muscle Biology Laboratory, School of Kinesiology, University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI, 48109-2214, USA, - - 2015
This review focuses on two paralogue Rab GTPase activating proteins known as TBC1D1 Tre-2/BUB2/cdc 1 domain family (TBC1D) 1 and TBC1D4 (also called Akt Substrate of 160 kDa, AS160) and their roles in controlling skeletal muscle glucose transport in response to the independent and combined effects of insulin and exercise. Convincing ...
Ritchie Ian R W IR Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, - - 2014
Adiponectin (Ad) is a potent insulin-sensitizing adipokine that has been found to activate pathways involved in the adaptation to exercise. Therefore, we examined whether Ad is required for the increased insulin response observed following exercise training in Ad knockout mice (AdKO). Eight weeks of exercise training significantly increased glucose and ...
Jodas Evelyn Manuella Martins Gomes EM Universidade Federal de São - - 2014
Introduction: It is still controversial whether there are synergistic effects among different non-pharmacological interventions used in the treatment of hypertension. Objetives: To evaluate the effect of aerobic exercise, oral supplementation of potassium and their combination on blood pressure, glucose metabolism, urinary albumin excretion and glomerular morphology in spontaneously hypertensive rats ...
Knudsen Sine H SH Department of Infectious Diseases, The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, - - 2014
We investigated glucose tolerance and postprandial glucose fluxes immediately after a single bout of aerobic exercise in subjects representing the entire glucose tolerance continuum. Twenty-four men with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or type 2 diabetes (T2D; age: 56 ± 1 years; body mass index: 27.8 ± ...
Blankenship Jennifer M JM Energy Metabolism Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, - - 2014
Recent evidence suggests that, like adding exercise, reducing sitting time may improve cardiometabolic health. There has not been a direct comparison of the 2 strategies with energy expenditure held constant. The purpose of this study was to compare fasting and postmeal glucose and insulin concentrations in response to a day ...
Skou Søren Thorgaard ST Orthopaedic Surgery Research Unit, Aalborg University Hospital, Research and Innovation Center, 15 Soendre Skovvej, 9000 Aalborg, Denmark. - - 2014
Education and exercise are poorly implemented in osteoarthritis care. The purpose of the present study was to identify predictors of effectiveness at one year from education and exercise in patients with knee or hip pain in clinical practice. Good Life with Arthritis in Denmark is an implementation initiative consisting of ...
Hao Zhe Z Department of Sports Anatomy, School of Sports Science, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, - - 2014
The objective of this study was to investigate the late cardiac effect of exercise preconditioning (EP) on the exhaustive exercise-induced myocardial injury in rats and the role of protein kinase C (PKC) in EP. Rats were subjected to a run on the treadmill for four periods of 10 min each at ...
Sinaei M M Department of Physical Education and Sport Sciences. Islamic Azad University Khorasgan, Arghavaniye, Isfahan, Iran. - - - 2014
The aim of this study was to compare BMI and the effects of a session of acute exercise on serum beta-endorphin levels among the sprint swimmers and runners. In a semi-experimental study, 15 healthy skilled male swimmers (mean and SD of age: 21.64 ± 2.35, Weight: 75.25 ± 9.81 kg, ...
Koseoglu E E Erciyes University, Faculty of Medicine, Neurology Department, Kayseri, Turkey - - - 2014
This review aims to provide a comprehensive overview of the literature on the use of exercise for migraine treatment with regard to its efficacy, mechanism of action and role in practice. Many randomised studies have reported the efficacy of prophylactic treatment of migrane with medications such as beta blockers or ...
Gross Micah M Institute for Anatomy, University of Bern, - - 2014
Supplementation with beta-alanine may have positive effects on severe-intensity, intermittent and isometric strength-endurance performance. These could be advantageous for competitive alpine skiers, whose races last 45 - 150 seconds, require metabolic power above the aerobic maximum and involve isometric muscle work. Further, beta-alanine supplementation affects the muscle force-frequency relationship, which ...
Bennett Matthew T MT Division of Cardiology, Department of Medicine, University of British Columbia, Arrhythmia Service, 9th Floor, Gordon & Leslie Diamond Health Care Centre, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9 - - 2014
Beta-blockers are the standard of care for the treatment of long QT syndrome (LQTS), and have been shown to reduce recurrent syncope and mortality in patients with type 1 LQTS (LQT1). Although beta-blockers have minimal effect on the resting corrected QT interval, their effect on the dynamics of the non-corrected ...
Hao Zhe Z Department of Sports Anatomy, School of Sports Science, Shanghai University of - - 2014
Background: Exercise preconditioning (EP) can provide powerful protection to the heart. Evidence supports the contention that EP directly enhances myocardial tolerance to ischaemia through a protein kinase C (PKC)-mediated mechanism. However, studies investigating the role of isoform-specific PKC after EP are lacking. Methods and Results: In this study, a male Sprague-Dawley rat ...
Sun Xiao-Juan XJ 1Department of Physical Education, Xianyang Normal University, Xianyang, China 2Department of Sports Anatomy, School of Sports Science, Shanghai University of Sport, Shanghai, - - 2014
to examine the role of calcitonin gene-related peptide (CGRP) in cardioprotection of short-term and long-term exercise preconditioning (EP). Male Sprague-Dawley rats were respectively subjected to continuous intermittent treadmill training 3 days or 3 weeks as short-term or long-term EP protocols. The myocardial injury induced by Isoproterenol (ISO) was performed 24h ...
Deftereos Spyridon S Department of Cardiology, Athens General Hospital "G. Gennimatas", Athens, Greece; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, - - 2014
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide production. The purpose of this study was to assess the correlation between ADMA and treadmill stress test outcome parameters with known prognostic value, in patients with intermediate risk for coronary artery disease (CAD). Study participants were referred for treadmill exercise ...
Kim Bo-Kyun BK Department of Physiology, College of Medicine, Kyung Hee University, Seoul, - - 2014
Alzheimer's disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impairment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer's disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present ...
Chung Weiliang W Department of Movement and Sports Sciences, Ghent University, Ghent, - - 2014
Muscle carnosine loading through chronic oral beta-alanine supplementation has been shown to be effective for short-duration, high-intensity exercise. This randomised, placebo controlled study explored whether the ergogenic effect of beta-alanine supplementation is also present for longer duration exercise. Subjects (27 well-trained cyclists/triathletes) were supplemented with either beta-alanine or placebo (6.4 ...
Douw Linda L Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands ; Department of Anatomy and Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The - - 2014
A healthy lifestyle is an important focus in today's society. The physical benefits of regular exercise are abundantly clear, but physical fitness is also associated with better cognitive performance. How these two factors together relate to characteristics of the brain is still incompletely understood. By applying mathematical concepts from 'network ...
Kudoh Yasuo Y Kidney Center, Sapporo South One Hospital, Sapporo, - - 2014
It is well known that the physical activity in chronic hemodialysis patients decreases compared to that in normal subjects. In order to investigate the effects of L-carnitine on physical capacity and lipid metabolism, a cardiopulmonary exercise test using a bicycle ergometer was performed before and after 3 months of oral ...
Matoulek M M Third Internal Medicine Clinic, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. - - 2014
The aim was to find the differences in ketogenesis initiation in the early period after the exercise in obese patients and to find if these changes may predict the weight loss during the physical activity program. 96 females were enrolled. A clamped heart rate test (CHR) was performed to establish ...
Gómez-Gómez Eduardo E Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Colima, - - 2014
Carnitine palmitoyltransferase IB (CPT1B) and adrenoceptor beta-3 (ADRB3) are critical regulators of fat metabolism. CPT1B transports free acyl groups into mitochondria for oxidation, and ADRB3 triggers lipolysis in adipocytes, and their respective polymorphisms E531K and W64R have been identified as indicators of obesity in population studies. It is therefore important ...
Kuehnbaum Naomi L NL Department of Chemistry and Chemical Biology, McMaster University, Hamilton, - - 2014
High-intensity interval training (HIIT) offers a practical approach for enhancing cardiorespiratory fitness, however its role in improving glucose regulation among sedentary yet normoglycemic women remains unclear. Herein, multi-segment injection capillary electrophoresis-mass spectrometry is used as a high-throughput platform in metabolomics to assess dynamic responses of overweight/obese women (BMI > 25, ...
Gallen Ian W IW Royal Berkshire NHS Foundation Trust Centre for Diabetes and Endocrinology, Royal Berkshire Hospital, Reading, - - 2014
Exercise in people with type 1 diabetes (T1DM) can produce large changes in blood glucose, with hypo- and hyperglycaemia before and following exercise. Different exercise types, intensity and duration have significantly different effects on blood glucose control, and on the endocrine response to exercise. Exercise performance can also be impaired ...
Koh Yunsuk Y Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, - - 2014
The current study examined the effects of niacin and a single bout of aerobic exercise on plasma glucose, insulin, and C-peptide in sedentary, nondiabetic postmenopausal women. As a crossover design, 17 participants underwent four different trials: rest during the no-niacin condition (R), exercise during the no-niacin condition (E), rest during ...
Sénéchal Martin M Manitoba Institute of Child Health, Winnipeg, MN, Canada ; Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, MN, - - 2014
Prediabetes is defined as impaired fasting glucose and/or impaired glucose tolerance. Impaired fasting glucose is usually defined as fasting blood glucose between 5.6 mmol/L and 6.9 mmol/L (100.8-124.2 mg/dL), and impaired glucose tolerance is the 2-hour oral glucose tolerance test of 7.8-11.0 mmol/L (140.4-198.0 mg/dL). Most individuals with prediabetes are ...
Smith-Ryan Abbie E - - 2013
Beta-alanine (BA) supplementation has been shown to delay neuromuscular fatigue as a result of increased muscle carnosine concentrations. Carnosine has also been found in brain and cardiac tissue. The physical working capacity test at heart rate threshold (PWCHRT ) is a global estimate of the onset of fatigue during exercise, ...
Antunes Ana Patrícia - - 2013
Deficiency of very-long-chain acyl-CoA dehydrogenase (VLCAD) is an autosomal recessive disease. Most common phenotypes occur in the neonatal period or in childhood with cardiomyopathy, hepatomegaly, and hypoketogenic hypoglycemia. Juvenile/adult-onset is characterized by exercise intolerance and recurrent rhabdomyolysis triggered by prolonged exercise or fasting. This article reports a patient with the ...
Gamze Erikoglu Orer - - 2013
This study examined the effect of acute L-carnitine loading on the endurance performance of footballers.Measurements were performed on 26 candidate professional footballers who volunteered to take part in the study. Athletes were given a glass of fruit juice one hour before applying L-carnitine with the double blind method. Then 12 ...
Gross Micah - - 2013
We aimed to manipulate physiological determinants of severe exercise performance. We hypothesized that (1) beta-alanine supplementation would increase intramuscular carnosine and buffering capacity and dampen acidosis during severe cycling, (2) that high-intensity interval training (HIT) would enhance aerobic energy contribution during severe cycling, and (3) that HIT preceded by beta-alanine ...
Lin Zhong - - 2013
Traditional Chinese eye exercises of acupoints involve acupoint self-massage. These have been advocated as a compulsory measure to reduce ocular fatigue, as well as to retard the development of myopia, among Chinese school children. This study evaluated the impact of these eye exercises among Chinese urban children. 409 children (195 ...
Vogt Tobias - - 2013
Artificial gravity (AG) exposure is suggested to counteract health deconditioning, theoretically complementing exercise during space habitations. Exercise-benefits on mental health are well documented (i.e. well-being, enhanced executive functions). Although AG is coherent for the integrity of fundamental physiological systems, the effects of its exposure on neurophysiological processes related to cognitive ...
Münzel Thomas - - 2013
The organic nitrate pentaerithrityl tetranitrate (PETN) has been shown to have ancillary properties that prevent the development of tolerance and endothelial dysfunction. This randomized, double-blind, placebo-controlled, multicentre study ('CLEOPATRA' study) was designed to investigate the anti-ischaemic efficacy of PETN 80 mg b.i.d. (morning and mid-day) over placebo in patients with ...
Molfino Alessio - - 2013
Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the branched-chain amino acid leucine, is extensively used by athletes and bodybuilders in order to increase strength, muscle mass and exercise performance. We performed a systematic review of the clinical literature on the effectiveness of HMB supplementation in healthy and pathological conditions (i.e. training programs, ...
Gamze Erikoglu Orer - - 2013
This study examined the effect of acute L-carnitine loading on the endurance performance of footballers.Measurements were performed on 26 candidate professional footballers who volunteered to take part in the study. Athletes were given a glass of fruit juice one hour before applying L-carnitine with the double blind method. Then 12 ...
Borisut Sudarat S Faculty of Physical Therapy, Mahidol - - 2013
[Purpose] To compare muscle activities and pain levels of females with chronic neck pain receiving different exercise programs. [Subjects and Methods] One hundred females with chronic neck pain participated in this study. They were randomly allocated into 4 groups (n = 25) on the basis of the exercises performed as ...
Khoury Asaad - - 2013
Calsequestrin (CASQ2) associated Catecholaminergic polymorphic ventricular tachycardia (CPVT2) can cause sudden death in young individuals in response to stress. Beta blockers are the mainstay medical treatment for CPVT2 patients. However, they do not prevent syncope and sudden death in all patients. Flecainide was reported to reduce exercise-induced ventricular arrhythmias (EIVA) ...
Alemo Munters Li - - 2013
This randomized, controlled study on patients with polymyositis or dermatomyositis was based on three hypotheses: Patients display impaired endurance due to reduced aerobic capacity and muscle weakness, endurance training improves their exercise performance by increasing the aerobic capacity, and endurance training has general beneficial effects on their health status. In ...
Díaz-Buschmann Isabel - - 2013
To verify the usefulness of current recommended level of target exercise heart rate (HR) and of different HR-based methods for calculating target HR in patients with and without beta-blocker treatment. We studied 53 patients not treated with beta-blocker and 159 patients on beta-blocker treatment. All patients underwent a maximal exercise ...
Martins Lilian Cristina - - 2013
Physical fitness is one of the most important qualities in armed forces personnel. However, little is known about the association between the military environment and the occupational and leisure-time dimensions of the physical activity practiced there. This study assessed the association of rank, job stress and psychological distress with physical ...
Fachko Michael J - - 2013
The purpose of this study was to quantify the cardiovascular responses and enjoyment of one trial of electronic exercise gaming (EG) (Nintendo(®) Wii(™) Tennis) in healthy, older adults (mean age = 81 [SD = 4 years]). Findings indicate that 15 minutes of EG moderately increased heart rate (p < 0.001), ...
1 2 3 4 5 6 7 8 9 10 >