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Reichkendler Michala Holm - - 2013
Physical exercise increases peripheral insulin sensitivity, but regional differences are poorly elucidated in humans. We investigated the effect of aerobic exercise training on insulin-stimulated glucose uptake in five individual femoral muscle groups and four different adipose tissue regions using dynamic (femoral region) and static (abdominal region) 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) PET/CT methodology ...
Nguyen Thanh - - 2013
Exercise is a viable form of therapy for children with cystic fibrosis (CF). Understanding the energy sources used during exercise would aid CF patients in obtaining proper nutrition in order to sustain an active lifestyle. Six boys with CF (mean age±SD: 14.8±2.3yrs, FEV1: 99±18% predicted) and six matched controls (14.0±2.2yrs) ...
Davey Raymond J - - 2013
Context:Exercise increases the risk of hypoglycemia in type 1 diabetes.Objective:Recently we reported a biphasic increase in glucose requirements to maintain euglycemia after late-afternoon exercise, suggesting a unique pattern of delayed risk for nocturnal hypoglycemia. This study examined whether this pattern of glucose requirements occurs if exercise is performed earlier in ...
Preisler Nicolai - - 2013
Context:Phosphoglucomutase type 1 (PGM1) deficiency is a rare metabolic myopathy in which symptoms are provoked by exercise.Objective:Because the metabolic block is proximal to the entry of glucose into the glycolytic pathway, we hypothesized that iv glucose could improve the exercise intolerance experienced by the patient.Design:This was an experimental intervention study.Setting:The ...
Park Sunmin - - 2013
AIMS: Preventing hyperglycemia after acute stroke attenuates complications of cerebral ischemia and reduces the risk of mortality. We investigated whether regular exercise prevents neuronal cell death and post-stroke hyperglycemia in gerbils after cerebral ischemia. MAIN METHODS: Cerebral ischemia was induced by carotid artery occlusion for 8 mins. The gerbils that ...
Kraemer Robert R - - 2013
INTRODUCTION: Prolonged exercise requires increased utilization of blood glucose and adjustment of glucoregulatory hormones. Estrogen can reduce hepatic gluconeogenesis which could affect insulin concentrations. Amylin is co-secreted with insulin and controls influx of glucose into the blood. PURPOSE: To determine the effect of menstrual cycle stage on glucose, leptin, and ...
Sherr Jennifer L - - 2013
OBJECTIVEAfternoon exercise increases the risk of nocturnal hypoglycemia (NH) in subjects with type 1 diabetes. We hypothesized that automated feedback-controlled closed-loop (CL) insulin delivery would be superior to open-loop (OL) control in preventing NH and maintaining a higher proportion of blood glucose levels within the target blood glucose range on ...
Newsom Sean A - - 2013
OBJECTIVEThe purpose of this study was to determine the effect of a relatively modest session of exercise on insulin sensitivity and fatty acid uptake the next day in obese adults.RESEARCH DESIGN AND METHODSEleven sedentary obese adults (male/female: 3/8; BMI 37 ± 1 kg/m(2); peak oxygen uptake [VO2peak] 20 ± 1 ...
Numao Shigeharu - - 2013
OBJECTIVE: A single bout of exercise can improve acute postprandial glucose metabolism aggravated by short-term low-carbohydrate/high-fat diet (HFD). The purpose of this study was to investigate the effect of a single bout of aerobic exercise on short-term HFD-induced postprandial glucose and incretin metabolism during an oral glucose tolerance test (OGTT). ...
Svidnicki Paulo Vinicius - - 2013
AIMS: Glucagon-like peptide-1 (GLP-1) is an important modulator of insulin secretion by endocrine pancreas. In the present study we investigated the effect of swim training on GLP-1 insulinotropic action in pancreatic islets from monosodium glutamate (MSG)-obese rats. METHODS: Obesity was induced by neonatal MSG administration. MSG-obese and control (CON) exercised ...
Perciavalle Valentina - - 2013
Abstract Blood levels of lactate and glucose were measured in 15 healthy male athletes with the purpose of evaluating possible correlation between their blood values and intensity and selectivity of attention, after a 30-min steady-state test performed at 60 and 80% of maximal oxygen consumption (VO2max). On the basis of ...
Sim A Y - - 2013
Objective:To examine the acute effects of high-intensity intermittent exercise (HIIE) on energy intake, perceptions of appetite and appetite-related hormones in sedentary, overweight men.Design:Seventeen overweight men (body mass index: 27.7±1.6 kg m(-2); body mass: 89.8±10.1 kg; body fat: 30.0±4.3%; VO2peak: 39.2±4.8 ml kg(-1) min(-1)) completed four 30-min experimental conditions using a randomised counterbalanced design. CON: resting control, ...
Delmonte V - - 2013
Allogeneic islet transplantation (IT) provokes changes in metabolic responses and nutritional behaviors. The durability of these changes needs to be described as well as their impact on the recipients' lifestyle. The goal of this study was to investigate how islet transplantation influenced diet, exercise habits, and body composition during 10 ...
Choi Eun-Young - - 2013
This study investigates the impact of exercises, coffee intakes, and physical trainings on fuel utilization in rats. Ninety-six rats were fed a control diet with either water (C) or coffee (CF; 0.12 g freeze-dried instant coffee/100 g body weight/d). Additionally, the animals go through physical training (TC and TCF) or ...
Liu Yiping - - 2013
Endothelial dysfunction (ED) is an early pathophysiological change in patients with impaired glucose tolerance (IGT) during prediabetes mellitus. This study was designed to test the hypothesis that exercise intervention contributes to the reversal of vascular endothelium-dependent dysfunction in middle-aged patients with IGT. Following exercise intervention, significant changes in endothelin (ET)-1, ...
Ahmadi Narges N Department of Exercise physiology, Fars Science & Research branch, Islamic Azad University, - - 2013
The purpose of this study was to examine the effects of 8 weeks moderate intensity aerobic exercise on serum retinol binding protein 4 (RBP4) levels in female athletes. Twenty female karate athletics were randomly assigned to one of the exercise group (n = 10) or control group (n = 10). ...
Stellingwerff Trent - - 2013
Recent studies have demonstrated a direct link between increased exogenous CHO oxidation (CHOexog) and enhanced performance. The limiting factor for CHOexog appears to be at the level of intestinal transporters, with sodium/glucose cotransporter 1 (SGLT1) and glucose transporter type 5 (GLUT5) responsible for glucose and fructose transport, respectively. Studies in ...
Kingsley Michael - - 2013
OBJECTIVES: This study compared the effects of three carbohydrate-hydration strategies on blood glucose concentration, exercise performance and hydration status throughout simulated soccer match-play. DESIGN: A randomized, double-blind and cross-over study design was employed. METHODS: After familiarization, 14 recreational soccer players completed the soccer match simulation on three separate occasions. Participants ...
Khazrai Yeganeh Manon - - 2013
To determine whether the administration of small amounts of glucose through an oral spray device (GSD) facilitates weight loss in overweight/obese subjects involved in a lifestyle modification programme. We randomly assigned 56 overweight/obese subjects to either the treatment group (n = 32) or the control group (n = 24). All subjects in both groups ...
Al-Nakkash L - - 2013
ABSTRACT Objective To investigate the effect of either genistein, or exercise, or both, on parameters that are indicators of cardiovascular health. Methods We investigated the effect of genistein treatment (300 mg genisten/kg body weight/day), or exercise training, or combined genistein and exercise training, for a period of 6-weeks on physical ...
Egli Léonie L Department of Physiology, University of Lausanne, Lausanne, - - 2013
Excess fructose intake causes hypertriglyceridemia and hepatic insulin resistance in sedentary humans. Since exercise improves insulin sensitivity in insulin-resistant patients, we hypothesized that it would also prevent fructose-induced hypertriglyceridemia. This study was therefore designed to evaluate the effects of exercise on circulating lipids in healthy subjects fed a weight-maintenance, high-fructose ...
Salvadori Alberto - - 2013
PURPOSE: It is demonstrated that aerobic exercise plays an important role in weight loss programs for obesity by increasing 24 h metabolic rate. While aerobic exercise can result in health and fitness benefits in obese subjects, also independently of weight loss, not completely clear are the effects of bouts of hard ...
Gordon Brett A - - 2013
The glycemic response to aerobic exercise is well understood; however, the response to resistance exercise is not. Eight inactive males (61.0 ± 7.2 years) with insulin-treated type 2 diabetes randomly completed single sessions of whole-body resistance exercise or cycling, 7 days apart. There were different 24-h glucose responses (p < ...
Malin Steven K - - 2013
Impaired glucose tolerance (IGT) is characterized by decreased oxidative capacity and reduced carbohydrate utilization during exercise. But, it is unclear if the presence of impaired fasting glucose (IFG) affects fuel utilization during exercise in adults with IGT. We tested the hypothesis that the presence of IFG in adults with IGT ...
Wallis Gareth A - - 2013
The consumption of carbohydrate before, during and after exercise is a central feature of the athlete's diet, particularly those competing in endurance sports. Sucrose is a carbohydrate present within the diets of athletes. Whether sucrose, by virtue of its component monosaccharide's glucose and fructose, exerts a meaningful advantage for athletes ...
Davitt Patrick M - - 2013
We investigated the effects of two exercise modalities on postprandial triglyceride (TG) and free fatty acid (FFA) metabolism. Sedentary, obese women were studied on 3 occasions in randomized order: Endurance exercise for 60 min at 60-65% VO2peak (E), ~60 min high-intensity resistance exercise (R), and a sedentary control trial (C). ...
Heden Timothy D - - 2013
PURPOSE: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) help regulate postprandial triacylglycerol (TAG) and insulin concentrations, but the effects of acute aerobic exercise on GLP-1 or GIP responses are unclear. The purpose of this study was to determine if reductions in postprandial TAG and insulin with ...
VAN Dijk Jan-Willem - - 2013
PURPOSE: We assessed the effect of a single bout of moderate-intensity exercise on subsequent 24-h glycemic control in 60 type 2 diabetes patients. Moreover, we examined whether individual responses to exercise were related to subjects' baseline characteristics, including age, body mass index, diabetes duration, exercise performance, medication, and HbA1c content. ...
O'Neill Hayley M - - 2013
[This corrects the article on p. 1 in vol. 37, PMID: 23441028.].
Dornbos David D - - 2013
Physical exercise preconditioning is known to ameliorate stroke-induced injury. In addition to several other mechanisms, the beneficial effect of preischemic exercise following stroke is due to an upregulated capacity to maintain energy supplies. Adult male Sprague-Dawley rats were used in exercise and control groups. After 1-3 weeks of exercise, several ...
Leon B - - 2013
Background:Obesity disproportionately affects women, especially those of African descent, and is associated with increases in both fat and muscle masses.Objective:Although increased extremity muscle mass may be compensatory to fat mass load, we propose that elevated insulin levels resulting from diminished insulin sensitivity may additionally contribute to extremity muscle mass in ...
Kimber Nicholas Eden - - 2013
The mechanisms facilitating increased skeletal muscle fat oxidation following prolonged, strenuous exercise remain poorly defined. The aim of this study was to examine the influence of plasma free fatty acid (FFA) availability on intramuscular malonyl-CoA concentration and the regulation of whole body fat metabolism during a 6 h post-exercise recovery ...
Oliveira Alexandre G - - 2013
Objective: It has become clear that exercise may be a useful therapy in the insulin resistance treatment, since it has anti-inflammatory effects and improves insulin sensitivity. However, it remains uncertain whether exercise affects the adipocytes or infiltrated macrophages. Thus, we aimed to investigate the effects of acute exercise on the ...
Hafstad Anne D - - 2013
Although exercise reduces several cardiovascular risk factors associated with obesity/diabetes, the metabolic effects of exercise on the heart are not well known. This study was designed to investigate whether high intensity interval training (HIT) is superior to moderate intensity training (MIT) in counteracting obesity-induced impairment of left ventricular (LV) mechanoenergetics ...
Chowdhury Kawshik K - - 2013
Meal-induced insulin sensitization (MIS) describes the augmented postprandial response to insulin through action of the hepatic insulin sensitizing substance (HISS). HISS-action is impaired in insulin resistance associated with aging and type 2 diabetes, but could be preserved by the antioxidant cocktail SAMEC, along with voluntary exercise. In this study, we ...
Roberts Shelley - - 2013
OBJECTIVE: The purpose of this study was to investigate the effects of pre-exercise and protein coingestion on the glycemic response to carbohydrates. METHODS: Twenty-one volunteers (13 males and 8 females) aged 22 y (± 3.8 y) participated in four trials in random order. These included: 1) glucose ingestion at rest ...
Morgan Paul M - - 2013
Flotation restricted environmental stimulation technique (R.E.S.T.) involves compromising senses of sound, sight, and touch by creating a quiet, dark environment. The individual lies supine in a tank of Epsom salt and water heated to roughly skin temperature (34-35oC). This study was performed to determine if a one hour flotation R.E.S.T. ...
Stefanov Tsvetan - - 2013
We examined the effect of a 6-month combined aerobic and resistance training programme on cardiometabolic risk factors in nondiabetic subjects and compared its effectiveness when executed under strict professional supervision or without direct supervision. Eighty-five sedentary, non-diabetic subjects (27 men and 58 women), mean age 47.5 +/- 0.6 years, mean ...
DeVan Allison E - - 2013
In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men and women without overt clinical disease. Compared with young adult controls ...
Kumareswaran Kavita K University of Cambridge Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom. - - 2013
Performance of continuous glucose monitors (CGMs) may be lower when glucose levels are changing rapidly, such as occurs during physical activity. Our aim was to evaluate accuracy of a current-generation CGM during moderate-intensity exercise in type 1 diabetes (T1D) pregnancy. As part of a study of 24-h closed-loop insulin delivery ...
de Moura Leandro Pereira - - 2013
ABSTRACT: It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyrosine phosphatase 1B (PTP-1B) in ...
Wax Benjamin - - 2013
ABSTRACT: The purpose of this investigation was to test the effects of carbohydrate supplementation on blood parameters and force output during superimposed electromyostimulation (SEMS) single leg isometric contractions. We hypothesized that carbohydrate ingestion prior and during muscle contractions would lead to greater glucose availability and greater total force output for ...
Lane Stephen C - - 2013
PURPOSE: Commencing selected workouts with low muscle glycogen availability augments several markers of training adaptation compared to undertaking the same sessions with normal glycogen content. However, low glycogen availability reduces the capacity to perform high intensity (>85% of peak aerobic power [V˙O2peak]) endurance exercise. We determined whether a low dose ...
Slivka Dustin - - 2013
PURPOSE: The purpose of this investigation was to determine the impact of post-exercise environmental cold exposure on muscle glycogen, PGC-1α, and downstream transcription factors. METHODS: Eight males cycled for 1 h and recovered in either 7° C (cold) or 20° C (room temp) environment for 4 h. Muscle biopsies were ...
Preisler Nicolai - - 2013
Myopathic symptoms in Glycogen Storage Disease Type IIIa (GSD IIIa) are generally ascribed to the muscle wasting that these patients suffer in adult life, but an inability to debranch glycogen likely also has an impact on muscle energy metabolism. We hypothesized that patients with GSD IIIa can experience exercise intolerance ...
Ebersbach-Silva Patricia - - 2013
To evaluate the effect of exposure to cigarette smoke and running training on a treadmill on the expression of glucose transporter GLUT4 in oxidative soleus muscle of rats. Wistar rats were divided into: (C) control, (E) exercise control, (SS), sedentary smoker, and (ES) exercise smoker. Insulin Tolerance Test, Western blotting, ...
Wylie Lee J - - 2013
Recent studies have suggested that dietary inorganic nitrate (NO(3) (-)) supplementation may improve muscle efficiency and endurance exercise tolerance but possible effects during team sport-specific intense intermittent exercise have not been examined. We hypothesized that NO(3) (-) supplementation would enhance high-intensity intermittent exercise performance. Fourteen male recreational team-sport players were ...
Trombold Justin R - - 2013
Acute exercise has been shown to attenuate postprandial plasma triglyceride elevation (PPTG). However, the direct contribution of exercise intensity is less well understood. The purpose of this study was to examine the effects of exercise intensity on PPTG and postprandial fat oxidation. One of three experimental treatments was performed in ...
Geat Mario - - 2013
OBJECTIVE: Fuel oxidation during exercise was studied in type 1 insulin-dependent (T1DM) patients mainly under quite constant insulin and glycemia; these protocols, however, likely do not reflect patients' usual metabolic conditions. The glucose oxidation rate (GLUox) in T1DM patients under usual life conditions was thus investigated during prolonged exercise (3-h) ...
Wax Benjamin - - 2013
ABSTRACT Glycine-arginine-α-ketoisocaproic acid (GAKIC) has been proposed to increase anaerobic high-intensity exercise performance in male subjects. However, the effects of GAKIC ingestion in female subjects have not been studied. Therefore, the purpose of this study was to investigate the effects of GAKIC supplementation on total load volume (i.e., mass lifted) ...
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