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- - 2014
Up to a third of care home residents may have sarcopenia (muscle dysfunction) and could benefit from exercise programmes to help manage the condition, suggests a review of prevalence and treatments.
Oppong Raymond R Arthritis Research UK Primary Care Centre, Keele University, Keele, Health Economics Unit, School of Health & Population Sciences, University of Birmingham, Birmingham, UK, Faculty of Health Sciences, Simon Fraser University, Burnaby, Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada and Centre for Health Sciences Research, University of Salford, Salford, UK. Arthritis Research UK Primary Care Centre, Keele University, Keele, Health Economics Unit, School of Health & Population Sciences, University of Birmingham, Birmingham, UK, Faculty of Health Sciences, Simon Fraser University, Burnaby, Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada and Centre for Health Sciences Research, University of Salford, Salford, - - 2014
Evidence regarding the cost-effectiveness of joint protection and hand exercises for the management of hand OA is not well established. The primary aim of this study is to assess the cost-effectiveness (cost-utility) of these management options. In addition, given the absence of consensus regarding the conduct of economic evaluation alongside ...
Burke Rita V RV 1Division of Pediatric Surgery,Children's Hospital Los Angeles,Los - - 2014
Introduction Children are particularly vulnerable during disasters and mass-casualty incidents. Coordinated multi-hospital training exercises may help health care facilities prepare for pediatric disaster victims. Problem The purpose of this study was to use mixed methods to assess the disaster response of three hospitals, focusing on pediatric disaster victims. A full-functional ...
Lamb Sarah E SE Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK. Electronic address: - - 2014
Disease-modifying biological agents and other drug regimens have substantially improved control of disease activity and joint damage in people with rheumatoid arthritis of the hand. However, commensurate changes in function and quality of life are not always noted. Tailored hand exercises might provide additional improvements, but evidence is lacking. We ...
Kromer Thilo O TO , School of Therapeutic Sciences, Department of Physiotherapy, SRH University Heidelberg, Heidelberg, The Netherlands. Thilo.Kromer@EPID.unimaas.nl, tok@ptz-physio.de, thilo.kromer@maastrichtuniversity.nl, - - 2014
Objectives: To investigate the effect of manual physiotherapy and exercises compared with exercises alone in patients with shoulder impingement syndrome one year after inclusion. Design: Randomized controlled trial. Subjects: Patients with shoulder impingement of more than 4 weeks. Methods: The intervention group received individualized manual physiotherapy plus individualized exercises; the ...
Schiffer Tomas A TA Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; - - 2014
The maximum power principle dictates that open biological systems tend to self-organize to a level of efficiency that allows maximal power production. Applying this principle to cellular energetics and whole-body physiology would suggest that for every metabolic challenge, an optimal efficiency exists that maximizes power production. On exposure to hypoxia, ...
Hannon Kevin R - - 2014
Exposure to high altitude decreases arterial oxygen saturation (Sa(O2)). Previous studies have shown decreased voltage of the T wave of the electrocardiogram (ECG) at altitudes up to 7000 m (22,966 ft) secondary to hypoxia. This pilot study explored changes in the ECG at the maximum altitude pilots can fly without ...
Robach Paul P 1Ecole Nationale des Sports de Montagne, site de l'Ecole Nationale de Ski et d'Alpinisme, Chamonix, France; 2Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark; 3Zurich Center for Integrative Human Physiology (ZIHP); 4Institute of Physiology, University of Zurich, Switzerland; 5Exercise Physiology, Institute of Human Movement Sciences, ETH Zurich, Zurich, - - 2014
The effects of hypoxic training on exercise performance remain controversial. Here we tested the hypotheses that i) hypoxic training possesses ergogenic effects at sea-level and altitude, and ii) the benefits are primarily mediated by improved mitochondrial function of skeletal muscle. We determined aerobic performance (incremental test to exhaustion and time ...
Faiss Raphael R ISSUL Institute of Sport Sciences, University of Lausanne, - - 2014
Hypoxia is known to reduce maximal oxygen uptake ( VO2max ) more in trained than in untrained subjects in several lowland sports. Ski mountaineering is practiced mainly at altitude. So elite ski-mountaineers spend significantly longer training duration at altitude than their lower level counterparts. Since acclimatization in hypobaric hypoxia is ...
Koehle Michael S MS *School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada; †Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; ‡SHSC Emergency Department, Toronto, Ontario, Canada; §Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada; and ¶Canadian Sport Institute Pacific-Vancouver Campus, Vancouver, British Columbia, - - 2014
: Many sports incorporate training at altitude as a key component of their athlete training plan. Furthermore, many sports are required to compete at high altitude venues. Exercise at high altitude provides unique challenges to the athlete and to the sport medicine clinician working with these athletes. These challenges include ...
Santos-Concejero J J UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South - - 2014
This study aimed to compare the response of performance-matched black and white runners during maximal and sub-maximal running in normoxic and hypoxic conditions. 14 well-trained runners (8 black, 6 white) performed 2 incremental maximal exercise tests and 2 fatigue resistance tests at 21% O2 (normoxia) or 14% O2 (hypoxia). Respiratory ...
Bourdillon Nicolas N ISSUL institute of Sport Sciences, University of Lausanne, Lausanne, 1015, Switzerland, - - 2014
The Richalet hypoxia sensitivity test (RT), which quantifies the cardiorespiratory response to acute hypoxia during exercise at an intensity corresponding to a heart rate of ~130 bpm in normoxia, can predict susceptibility of altitude sickness. Its ability to predict exercise performance in hypoxia is unknown. Investigate: (1) whether cerebral blood flow ...
Goods P S R SR School of Sport Science, Exercise and Health. University of Western - - 2014
This study aimed to assess the impact of three simulated altitude exposure heights on repeat sprint performance in team sport athletes. Ten trained male team sport athletes completed three sets of repeated sprints (9 x 4 s) on a non-motorised treadmill at sea-level or at simulated altitudes of 2000, 3000 ...
Barhoumi Tlili T aLady Davis Institute for Medical Research bDepartment of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada cState University of Rio de Janeiro, Rio de Janeiro, Brazil dUniversité d'Avignon et des Pays de Vaucluse-Avignon, Avignon eDepartment of Pharmacology and Institut National de la Santé et de la Recherche Médicale U970-PARCC, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, - - 2014
Erythropoietin used to correct anaemia in chronic kidney disease (CKD) has been shown to increase blood pressure (BP) in CKD patients and experimental animals. Endothelin (ET)-1 expression is increased in CKD animals and patients, and enhanced by erythropoietin. Erythropoietin-induced BP rise was blunted by ETA receptor blockers. This study was ...
Crocker George H GH School of Veterinary Medicine, Department of Surgical and Radiological Sciences, University of California, One Shields Avenue, Davis, CA, 95616, - - 2014
To determine if and how hypoxia combined with elevated carboxyhaemoglobin fraction (F HbCO) affects peripheral diffusing capacity and O2 extraction in animals exercising at their maximal aerobic capacity ([Formula: see text]). Six goats ran on a treadmill at speeds eliciting [Formula: see text] while breathing inspired O2 fractions (F IO2) ...
Subudhi Andrew W AW Altitude Research Center, Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America; Department of Biology, University of Colorado Colorado Springs, Colorado Springs, Colorado, United States of - - 2014
An understanding of human responses to hypoxia is important for the health of millions of people worldwide who visit, live, or work in the hypoxic environment encountered at high altitudes. In spite of dozens of studies over the last 100 years, the basic mechanisms controlling acclimatization to hypoxia remain largely ...
Hawkes Lucy A LA School of Biological Sciences, Bangor University, Bangor, Gwynedd, United Kingdom; University of Exeter, College of Life and Environmental Sciences, Penryn Campus, Penryn, Cornwall, United - - 2014
While bar-headed geese are renowned for migration at high altitude over the Himalayas, previous work on captive birds suggested that these geese are unable to maintain rates of oxygen consumption while running in severely hypoxic conditions. To investigate this paradox, we re-examined the running performance and heart rates of bar-headed ...
Núñez-Espinosa Cristian C Departament de Fisiologia i Immunologia, Universitat de Barcelona, Av. Diagonal, 643; Edifici Ramon Margalef, Facultat de Biologia, E-08028 Barcelona, - - 2013
Intermittent hypobaric hypoxia (IHH) exposure, accompanied or not with active recovery, can help to skeletal muscle repair. However, the erythropoietic response elicited can disturb blood rheology and thus alter the oxygen delivery to tissues. Male Sprague-Dawley rats were studied in two basal states: untrained and trained and compared with early ...
Desplanches Dominique - - 2013
We explored whether altered expression of factors tuning mitochondrial metabolism contributes to muscular adaptations with endurance training in the condition of lowered ambient oxygen concentration (hypoxia) and whether these adaptations relate to oxygen transfer as reflected by subsarcolemmal mitochondria and oxygen metabolism in muscle. Male volunteers completed 30 bicycle exercise ...
Erken Haydar Ali HA 1 Department of Physiology, Faculty of Medicine, Balikesir University , Balikesir, Turkey - - 2013
Abstract Erken, Haydar Ali, Gülten Erken, Ridvan Çolak, Osman Genç. Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. High Alt Med Biol 14:360-366, 2013.-It is known that hypoxia has a negative effect on nervous system functions, but exercise and DHA (docosahexaenoic acid) have ...
Chapman Robert F - - 2013
Performance in athletic activities that include a significant aerobic component at mild or moderate altitudes shows a large individual variation. Physiologically, a large portion of the negative effect of altitude on exercise performance can be traced to limitations of oxygen diffusion, either at the level of the alveoli or the ...
Billaut François - - 2013
The internationalism of field-based team sports (TS) such as football and rugby requires teams to compete in tournaments held at low to moderate altitude (∼1200-2500 m). In TS, acceleration, speed and aerobic endurance are physical characteristics associated with ball possession and, ultimately, scoring. While these qualities are affected by the ...
Saunders Philo U - - 2013
Endurance athletes have been using altitude training for decades to improve near sea-level performance. The predominant mechanism is thought to be accelerated erythropoiesis increasing haemoglobin mass (Hbmass) resulting in a greater maximal oxygen uptake ( O2max). Not all studies have shown a proportionate increase in O2max as a result of ...
Aughey Robert J - - 2013
We investigated the effect of high altitude on the match activity profile of elite youth high altitude and sea level residents. Twenty Sea Level (Australian) and 19 Altitude-resident (Bolivian) soccer players played five games, two near sea level (430 m) and three in La Paz (3600 m). Match activity profile ...
Suto Takashi T Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. Electronic address: - - 2013
With the development of transportation technologies, elderly people with chronic diseases are increasingly enjoying trekking and tours of nature resorts that include mountain highlands. Because of problems related to circulation, respiration, metabolism, and/or the musculoskeletal system in this population, the impact of high altitude on cardiopulmonary function is increased. Alpine ...
Dhillon Rashpal S - - 2013
Abstract The gills of many fish, but in particular those of crucian carp (Carassius carassius) and goldfish (Carassius auratus), are capable of extensive remodeling in response to changes in oxygen (O2), temperature, and exercise. In this study, we investigated the interspecific variation in hypoxia-induced gill modeling and hypoxia tolerance in ...
Baumann Cory W - - 2013
Oral supplementation of echinacea purpurea (ECH) has been reported to increase levels of serum erythropoietin (EPO) and as a result improve endurance performance in untrained subjects. The purpose of this study was to determine if ECH supplementation alters maximal oxygen uptake (VO2max) in trained endurance runners. Using a double-blind design, ...
Baumann Cory W - - 2013
Oral supplementation of echinacea purpurea (ECH) has been reported to increase levels of serum erythropoietin (EPO) and as a result improve endurance performance in untrained subjects. The purpose of this study was to determine if ECH supplementation alters maximal oxygen uptake (VO2max) in trained endurance runners. Using a double-blind design, ...
West John B - - 2013
Joseph Barcroft (1872-1947) was an eminent British physiologist who made contributions to many areas. Some of his studies at high altitude and related topics are reviewed here. In a remarkable experiment he spent six days in a small sealed room while the oxygen concentration of the air gradually fell simulating ...
Christensen Britt B Department of Endocrinology and Internal Medicine, NBG/THG, Aarhus University Hospital, Aarhus, - - 2013
Erythropoietin (Epo) administration improves aerobic exercise capacity and insulin sensitivity in renal patients and also increases resting energy expenditure (REE). Similar effects are observed in response to endurance training. The aim was to compare the effects of endurance training with erythropoiesis-stimulating agent (ESA) treatment in healthy humans. Thirty-six healthy untrained ...
Scott Brendan R - - 2013
While the back squat exercise is commonly prescribed to both athletic and clinical populations, individuals with restricted glenohumeral mobility may be unable to safely support the bar on the upper trapezius using their hands. The aims of this study were to investigate the validity and reliability of a back squat ...
Porteus C S CS Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, - - 2014
This study examined mechanisms underlying cardio-respiratory acclimation to moderate sustained hypoxia (6·0 kPa for 7 days at 22° C) in the bowfin Amia calva, a facultative air-breathing fish. This level of hypoxia is slightly below the critical oxygen tension (pcrit ) of A. calva denied access to air (mean ± s.e. = 9·3 ± 1·0 kPa). ...
Crocker George H - - 2013
We hypothesized that breathing hypoxic, hypercapnic and CO-containing gases together reduces maximal aerobic capacity (VO2max) as the sum of each gas's individual effect on VO2max. To test this hypothesis, goats breathed combinations of inspired O2 fraction (FIO2) 0.06-0.21 and inspired CO2 fraction 0.00 or 0.05 with and without inspired CO ...
Lin Xixiu - - 2013
The protective effect of Erythropoietin (EPO) analogue rHuEPO on acute renal injury induced by exhaustive exercise had been reported. The purpose of this study is to probe into the protective effect of EPO on chronic renal injury induced by repeated exhaustive exercise for four weeks. Eighty adult male Sprague--Dawley rats ...
Kume D - - 2013
Aim: This study examined the effect of intermittent breath holding (IBH) on physiological response, including oxygenation in working muscle, to moderate-intensity exercise. Methods: Thirteen men performed bicycle exercise for 5 min at 65% of peak oxygen uptake with normal breathing (NB) and with IBH. Muscle oxygenation, concentration changes of oxyhemoglobin ...
Agostoni Piergiuseppe - - 2013
Abstract Piergiuseppe Agostoni. Considerations on safety and treatment of patients with chronic heart failure at high altitude. High Alt Med Biol 14:96-100, 2013.-Prognosis and quality of life of chronic heart failure (HF) patients have greatly improved over the last decade. Consequently, many patients are willing to spend leisure time at ...
Guo Ping - - 2013
The aim of our study was to develop a model of high altitude cerebral edema (HACE) using an acute, hypobaric hypoxia environment combined with exhaustive exercise. Forty healthy male Sprague-Dawley rats were randomly divided into a plains control group (PC group) and a plateau altitude hypoxia group (AH group). After ...
Endo Kana - - 2013
The Stroop test was performed before and after ergometer exercise for 15 min at 20, 40, and 60 % of maximum voluntary exercise (EXmax), in order to examine whether dynamic exercise is capable of improving cognitive function and whether the changes in regional cerebral blood flow of the prefrontal cortex are associated ...
Choi Jeong June - - 2013
BACKGROUND: The gut microbiome is a dynamic bacterial community that interacts with the host and closely relates to human health by regulating energy metabolism and immune functions. Recent reports also point to the role of the gut microbiome in risk assessment to environmental toxicants. OBJECTIVES: To investigate the effects of ...
Gatterer H H Department of Sport Science, University Innsbruck, - - 2013
Reports based on experiences from masseurs and players, mostly without any scientific background, suggest that the combination of a classical regeneration method (i.e. massage) with exposure to hypoxia may enhance regeneration in soccer. The aim of this study was to evaluate whether this specific combination could affect blood parameters related ...
Stover Kristin K - - 2013
The Atlantic blue crab, Callinectes sapidus (Rathbun), is a highly mobile crustacean that must locomote to find food, evade predators, find mates, and avoid adverse conditions such as hypoxia. In this study we tested the effects of two levels of hypoxia (10.4 kPa, 50% air saturation = moderate hypoxia; 4 ...
Waltz Xavier - - 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established 6-minute-walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before ...
Bor-Kucukatay Melek - - 2013
Altitude training is frequently used by athletes to improve sea-level performance. However, the objective benefits of altitude training are controversial. This study aimed to investigate the possible alterations in hemorheological parameters in response to altitude training. Sprague Dawley rats, were divided into 6 groups: live low-train low (LLTL), live high-train ...
Kounalakis S N - - 2013
We investigated the effect of hypoxic acclimatization per se, without any concomitant influence of strenuous physical activity on muscle and cerebral oxygenation. Eight healthy male subjects participated in a crossover-designed study. In random order, they conducted a 10-day normoxic (CON) and a 10-day hypoxic (EXP) confinement. Pre and post both ...
Kelaidi C - - 2013
Darbepoetin (DAR), with or without granulocyte colony-stimulating factor (G-CSF), has proved effective in treating anemia in patients with lower-risk myelodysplastic syndrome (MDS), but its effects on quality of life (QoL) and exercise functioning are less well established. In this phase II study (no. NCT00443339), lower-risk MDS patients with anemia and ...
Davis Michelle L - - 2013
We calculated the light-absorbing-potential (LAP) of hemoglobin (Hb) and myoglobin (Mb) in mammalian skeletal muscle at rest based on analysis of published chemical and morphometric data (Part 1), interpreted changes in total [Hb+Mb] from NIRS during exercise (Part 2), and estimated the potential contribution of Hb and Mb to changes ...
NowiƄski Adam - - 2013
Dyspnoea and decreased exercise tolerance are symptoms of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Anaemia is a risk factor for reduced functional capacity and dyspnoea in stable COPD. There is limited information about the impact of anaemia on functional capacity and dyspnoea of patients during AECOPD. The aim ...
Zebrowska Aleksandra - - 2013
The objective of the study was to investigate whether a blood pressure increase during static exercises might affect the left ventricular function and whether a possible pressure overload might decrease cardio-respiratory adaptation to aerobic exercise in power lifting athletes. Nine resistance-trained athletes and ten age-matched untrained men participated in high ...
Wiseman Rachel L - - 2013
Healthy individuals are known to have significantly reduced oxygen saturations at rest when acutely exposed to moderate altitudes, such as during commercial flight. There is a paucity of data on the response of healthy individuals to exercise at these altitudes. The aim of this study was to establish the normal ...
Nachbauer Wolfgang - - 2013
Friedreich ataxia (FRDA) is caused by a GAA repeat expansion in the FXN gene leading to reduced expression of the mitochondrial protein frataxin. Recombinant human erythropoietin (rhuEPO) is suggested to increase frataxin levels, alter mitochondrial function and improve clinical scores in FRDA patients. Aim of the present pilot study was ...
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