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Kemi Ole J - - 2010
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts that associate with detubulation, by confocal laser scanning microscopy. First, exercise training in ...
Bailón Raquel - - 2011
In this paper, an approach for heart rate variability analysis during exercise stress testing is proposed based on the integral pulse frequency modulation (IPFM) model, where a time-varying threshold is included to account for the nonstationary mean heart rate. The proposed technique allows the estimation of the autonomic nervous system ...
Hydock David S - - 2011
Doxorubicin (DOX) and goserelin acetate (GA), when administered individually, can lead to impaired cardiac function via different mechanisms. Combining GA and DOX (GA + DOX), however, could potentially exacerbate cardiac dysfunction when compared to GA and DOX treatments administered individually. Therefore, the first purpose of this study was to investigate the effects ...
Bourque Jamieson M JM Cardiovascular Division, Department of Medicine, University of Virginia Health System, P.O. Box 800158, 1215 Lee Street, Charlottesville, VA 22908, USA. - - 2011
The benefit of myocardial perfusion imaging (MPI) over exercise ECG stress testing alone is unclear in individuals attaining a workload of ≥10 METS. The purpose of this prospective study is to determine mortality and nonfatal cardiac events in patients at either intermediate pretest risk for CAD or patients with known ...
Yang Chang-Bin - - 2010
Musculoskeletal and cardiovascular deconditioning occurring in long-term spaceflight gives rise to the needs to develop new strategies to counteract these adverse effects. Short-arm centrifuge combined with ergometer has been proposed as a strategy to counteract adverse effects of microgravity. This study sought to investigate whether the combination of short-arm centrifuge ...
Almeida Ana Rita - - 2010
The authors report the case of a 64-year-old patient with hypertrophic cardiomyopathy with latent obstruction. The patient complained of fatigue but the left ventricular outflow gradient at rest was not significant. He underwent exercise echocardiography that was stopped after 3 minutes due to exhaustion. The gradient at peak workload was ...
Schweitzer Cyril - - 2010
Forced expiratory volume in 1 s (FEV1) detection of exercise-induced bronchoconstriction (EIB) to identify asthma has good specificity but rather low sensitivity. The aim was to test whether sensitivity may be improved by measuring respiratory resistance (Rrs) by the forced oscillation technique (FOT). Forty-seven asthmatic and 50 control children (5-12 ...
Krakowiak Bartosz - - 2010
Background and aim: Pattern of heart rate (HR) changes during exercise and recovery is deranged in patients with cardiovascular disease, being considered as an independent predictor of poor outcome. This issue has been poorly examined in patients with chronic heart failure (CHF), particularly in the early stages of this syndrome. ...
Reboredo Maycon de Moura - - 2010
INTRODUCTION: Decreased heart rate variability (HRV) in patients with end stage renal disease (ESRD) undergoing hemodialysis is predictive of cardiac death, especially due to sudden death. OBJECTIVE: To evaluate the effects of aerobic training during hemodialysis on HRV and left ventricular function in ESRD patients. METHODS: Twenty two patients were ...
Jae Sae Young - - 2011
Heart rate recovery (HRR) after treadmill exercise testing is an index of cardiac autonomic activity in non-disabled persons, but it is unknown if this is also the case in individuals with spinal cord injury (SCI). We investigated the relationship between HRR after maximal arm exercise testing and resting autonomic activity ...
Galbreath M Melyn - - 2010
PURPOSE: Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these patients. METHODS: Seventeen POTS patients aged 27 ± 9 (mean ± SD) years underwent an exercise training ...
Mansur Alfredo Jose - - 2010
Evaluation of: Gulati M, Shaw LJ, Thisted RA, Black HR, Bairey Merz CN, Arnsdorf MF: Heart rate response to exercise stress testing in asymptomatic women: The St. James Women Take Heart Project. Circulation 122, 130-137 (2010). Peak heart rate achieved with exercise in 5437 asymptomatic women submitted to symptom-limited exercise ...
Bikov András - - 2010
Although the importance of cysteinyl leukotrienes (Cys-LTs) in exercise-induced bronchoconstriction (EIB) is supported by various sources of evidence, how the concentration of these mediators change during the development of EIB has not been investigated. Our goal was to determine the effect of exercise on the concentration of airway Cys-LT in ...
Giallauria Francesco - - 2011
High-mobility group box-1 (HMGB1) is a novel predictor of adverse postinfarction clinical outcomes, playing a crucial role in the appropriate postinfarction healing process. Seventy-five postinfarction patients were enrolled in a single-center randomized study (clinicaltrial.gov identifier: NCT00755131). Group T patients (training, n = 37) underwent 6-month exercise-based cardiac rehabilitation (CR) program, ...
Seljeflot Ingebjørg - - 2011
The aim of this study was to relate levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, L-arginine, the substrate for NO generation, and radical oxygen species (ROS) formation to severity of chronic heart failure. The effect of 4 months' group-based exercise training was further investigated. ...
Cocco Giuseppe - - 2011
In spite of appropriate pharmacologic therapy, many hypertensive patients develop an abnormal left ventricular relaxation with preserved systolic function. This cardiac dysfunction increases the risk of cardiovascular complications. The authors assessed the therapeutic effects of an intervention with exercise training and weight reduction in patients with pharmacologically well-treated hypertension who ...
Kippelen Pascale - - 2010
The role of mast cells in the airway response to exercise and the benefit of sodium cromoglycate (SCG) in athletes are unclear. The purpose of this study was to clarify the role of mast cell mediators in the airway response to exercise in athletes and to investigate the effect of ...
Petter Hedelin H GoRadLab, The Öresund Cardiovascular Research Collaboration, The Clinic for heart Failure and valvular heart disease, Department of Cardiology, Lund University and Skåne University Hospital, Sweden. - - 2011
This study compared the non-invasive thoracic electrical bioimpedance Aesculon technique (TEB(Aesculon) ) with thermodilution (TD) to evaluate whether TEB(Aesculon) may offer a reliable means for estimating cardiac output (CO) in humans. Cardiac output was measured with TD and TEB(Aesculon) in 33 patients, with a mean age ± SEM of 59 ...
Peteiro Jesus - - 2010
Exercise echocardiography has been used for 30 years. It is now considered a consolidated technique for the diagnosis and risk stratification of patients with known or suspected coronary artery disease (CAD). Of the stress echocardiography techniques, it represents the first choice for patients who are able to exercise. Given that ...
Anderson Sandra D - - 2010
Indirect challenges cause the release of endogenous mediators that cause the airway smooth muscle to contract and the airways to narrow. Airway sensitivity to indirect challenges is reduced or even totally inhibited by treatment with inhaled corticosteroids (ICS), so a positive response to an indirect stimulus is believed to reflect ...
Ramos Plínio Santos PS Universidade Gama Filho, Rio de Janeiro, RJ, - - 2010
Exaggerated systolic blood pressure (SBP) levels during a maximal cardiopulmonary exercise test (CPET) are classically considered as inappropriate and associated with a higher risk for the development of cardiovascular diseases. It is known that the autonomic nervous system modulates the BP during exercise. However, the behavior of the cardiac vagal ...
Scichilone Nicola - - 2010
Airway responsiveness to methacholine (Mch) in the absence of deep inspirations (DIs) is lower in athletes compared with sedentary individuals. In this prospective study, we tested the hypothesis that a training exercise program reduces the bronchoconstrictive effect of Mch. Ten healthy sedentary subjects (M/F: 3/7; mean + or - SD ...
Fogel Robert B - - 2010
OBJECTIVES: To evaluate the effect of montelukast, 5 mg, or inhaled salmeterol, 50 microg, added to inhaled fluticasone in reducing the maximum percentage decrease in forced expiratory volume in 1 second (FEV1) after a standardized exercise challenge and response to rescue bronchodilation with albuterol in children aged 6 to 14 ...
Boaventura L C - - 2010
Exercise-induced bronchospasm (EIB) is the transient narrowing of the airways that follows vigorous exercise. Ipratropium bromide may be used to prevent EIB, but its effect varies among individuals. We hypothesized that time of administration of ipratropium interferes with its action. This was a prospective, double-blind, cross-over study carried out to ...
Sue-Chu Malcolm - - 2010
Methacholine hyperresponsiveness is prevalent in elite athletes. Comparative studies have hitherto been limited to methacholine, eucapnic voluntary hyperpnoea and exercise. This study investigated airway responsiveness to these stimuli as well as to adenosine 5'-monophosphate (AMP) and mannitol, in 58 cross-country ski athletes. Exhaled nitric oxide concentration (F(E)NO), spirometry and bronchial ...
Pereira Danielle Aparecida Gomes - - 2010
The anaerobic threshold (AT) provides information on functional capacity in heart failure (HF). However, the visual determination of the AT by ventilatory methods is subjective, being susceptible to differences between examiners. To evaluate the inter- and intra-examiner reproducibility in the determination of the AT in patients with mild to moderate ...
Elahi Maqsood - - 2010
The pathophysiology of several conditions including heart failure is partly attributable to a failure of the cell energy metabolism. Studies have shown that exercise training (ET) improves quality of life (QOL) and is beneficial in terms of reduction of symptoms, mortality and duration of hospitalization. Increasingly, ET is now achieving ...
Chimenti Laura - - 2010
High neutrophil counts in induced sputum have been found in nonasthmatic amateur runners at rest and after a marathon, but the pathogenesis of airway neutrophilia in athletes is still poorly understood. Bronchial epithelial damage may occur during intense exercise, as suggested by investigations conducted in endurance-trained mice and competitive human ...
Hassan Nesreen M - - 2010
Patients with chronic obstructive pulmonary disease (COPD) demonstrate airway hyperresponsiveness to a number of indirect stimuli. Hyperresponsiveness to cold air hyperventilation, exercise, and drugs like propranalol and methoxamine seem to be able to distinguish patients with COPD from those with asthma, whereas hyperresponsiveness to stimuli like adenosine 5-monophosphate (AMP) and ...
Randolph Chris - - 2010
Exercise induced bronchconstriction (EIB) is defined as a transient increase in airway resistance reflected as at least a 10% decline in FEV1 following at least 6-8 minutes of strenuous exercise. Up to 90% of asthmatics, 45% of individuals with allergic rhinitis, 50% of Olympic athletes, and 12% of the general ...
Cowan Douglas C - - 2010
Exercise-induced wheeze (EIW) is common. Several treatment options exist. Patients with low fraction of exhaled nitric oxide (F(E)NO) are unlikely to be steroid-responsive and might benefit from non-steroidal therapies. We assessed: the efficacy of cromoglycate, formoterol and montelukast in patients with EIW and low F(E)NO (<35 ppb) in a randomized ...
Lavorini Federico - - 2010
Little is known about the effects of exercise on the sensory and cognitive aspects of coughing evoked by inhalation of tussigenic agents. The threshold for the cough reflex induced by inhalation of increasing nebulizer outputs of ultrasonically nebulized distilled water (fog), an index of cough reflex sensitivity, was assessed in ...
Carvalho Vitor Oliveira - - 2010
Physical training for chronic heart failure (CHF) patients is well known in the scientific realm, although there are many different methods of physical exercise prescribed and different ways of monitoring such training. The object of this review is to discuss prescription and monitoring methods of physical exercise for CHF patients. ...
Zietkowski Ziemowit - - 2010
BACKGROUND: Exercise-induced bronchoconstriction (EIB) in asthmatics depends on the presence of allergic inflammation. This study was performed to assess the possible association of EIB with low-grade systemic inflammation, whose presence was revealed in asthmatic patients. METHODS: The study was conducted in a group of 24 asthmatics (14 with EIB, 10 ...
Fontana Giovanni A - - 2010
No information exists on the effects of hyperpnea on the sensory and cognitive aspects of coughing evoked by inhalation of tussigenic agents. The threshold for the cough reflex induced by inhalation of increasing concentrations of ultrasonically nebulized distilled water (fog), and the index of cough reflex sensitivity, was assessed in ...
Anderson Sandra D - - 2010
Exercise testing to aid diagnosis of exercise-induced bronchoconstriction (EIB) is commonly performed. Reproducibility of the airway response to a standardized exercise protocol has not been reported in subjects being evaluated with mild symptoms suggestive of asthma but without a definite diagnosis. This study examined reproducibility of % fall in FEV1 ...
Abdul-Waheed Mohammad - - 2010
Heart transplant (HT) recipients demonstrate limited exercise capacity compared to normal patients, very likely for multiple reasons. In this study we hypothesized that left atrial volume (LAV), which is known to predict exercise capacity in patients with various cardiac pathologies including heart failure and hypertrophic cardiomyopathy is associated with limited ...
Engblom Henrik - - 2010
An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO2peak) which has previously been shown to be closely related to total heart volume (THV). Thus, ...
Burns J Bracken JB Jr Department of Surgery, University of Florida-Jacksonville, FL 32209, USA. - - 2010
The ever-present risk of mass casualties and disaster situations may result in airway management situations that overwhelm local emergency medical services (EMS) resources. Endotracheal intubation requires significant user education/training and carries the risk of malposition. Furthermore, personal protective equipment (PPE) required in hazardous environments may decrease dexterity and hinder timely ...
Shanati Allah - - 2009
To find out whether serum oxidizability potential correlates with exercise test (EXT) parameters and predicts their results in chronic ischemic heart disease (IHD) patients. Oxidizability potential was determined in a group of chronic IHD patients who underwent a symptom limited EXT upon initiation of a cardiac rehabilitation program. The thermo-chemiluminescence ...
Zietkowski Z - - 2010
The response of asthmatics to exercise differs from that of healthy subjects, and the mechanisms responsible for exercise-induced bronchoconstriction (EIB) remain to be elucidated. The aim of this study was to evaluate changes in RANTES levels in exhaled breath condensate (EBC) following intensive exercise in allergic asthmatics. The study was ...
Antosova M - - 2009
Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. The level of eNO is influenced by many various factor including age, sex, menstrual cycle, exercise, food, drugs, etc. The aim of our study was to investigate a potential influence of circadian variation on eNO level ...
Weiss Pnina - - 2009
Exercise-induced bronchoconstriction (EIB) is described by transient narrowing of the airways after exercise. It occurs in approximately 10% of the general population, while athletes may show a higher prevalence, especially in cold weather and ice rink athletes. Diagnosis of EIB is often made on the basis of self-reported symptoms without ...
Clearie K L - - 2010
BACKGROUND: Chlorine metabolites and high training load may produce exercise-induced bronchospasm (EIB) in elite swimmers. The aim of this study was to assess the combined effects of chlorine and exercise on the unified airway of adolescent elite swimmers. METHODS: The Scottish Midlands District squad were assessed during an indoor pool ...
Røksund Ola Drange - - 2009
BACKGROUND: Exercise induced asthma may symptomatically be difficult to differentiate from exercise related obstruction in the upper airways, sometimes leading to diagnostic confusion and inappropriate treatment. Larynx accounts for a significant fraction of total airway resistance, but its role as a limiting factor for airflow during exercise has been hampered ...
Spector Sheldon - - 2010
Bronchial provocation testing uses a variety of direct and indirect inhalational challenges to evaluate airway hyperreactivity. Mannitol, a simple, easy-to-administer hypertonic stimulus available in many countries, is currently under review by the FDA in the US. Healthy subjects show no airway response to inhaled mannitol; asthmatic patients respond with airway ...
Millen Jennifer A - - 2009
Resistance training offers clinical and functional benefits to cardiac patients, yet exercise adherence after cardiac rehabilitation (CR) is problematic. This study examined effects of an intervention targeting self-efficacy, outcome expectations, and adherence to upper-body resistance exercise after CR. Cardiac patients (N = 40) were randomly allocated to receive either standard ...
McKune, AJ; ;
The prevalence of asthma and airway hyperresponsiveness (AHR) in highly trained endurance athletes is rising. The type of training (i.e. endurance, or speed and power) seems to influence the airway symptoms. High-intensity exercise and training might contribute to the development of asthma or AHR in athletes previously unaffected by these ...
St-Laurent Julie - - 2009
BACKGROUND: Alveolar macrophages (AM) are the most numerous immune cells in the airways and are involved in the immunological homeostasis of the lung. Intriguingly, their role in asthma remains unclear probably, in part, because of their heterogeneity. OBJECTIVE: To characterize AM population from bronchoalveolar lavage (BAL) and induced sputum (IS) ...
Bougault V - - 2009
Endurance athletes show an increased prevalence of airway hyperresponsiveness. The aim of the present study was to evaluate the long-term effects of training on airway responsiveness, inflammation and epithelial damage in swimmers and cold-air athletes. In total, 64 elite athletes (32 swimmers and 32 cold-air athletes), 32 mild asthmatic subjects ...
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