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Corrà Ugo - - 2011
Aims: The study aims were to validate the cardiopulmonary exercise testing (CPET) parameters recommended by the European Society of Cardiology 2008 Guidelines for risk assessment in heart failure (HF) (ESC-predictors) and to verify the predictive role of 11 supplementary CPET (S-predictors) parameters. Methods and results: We followed 749 HF patients ...
Bellotto Fabio - - 2011
Background and aims: Anemia seems to be rather common in cardiac rehabilitation patients but it is not known whether it could influence cardiovascular performance indexes and prognosis immediately after an acute cardiac event. The purposes of this study were to define its prevalence and to investigate the safety and efficacy ...
Beyranvand Mohamad Reza - - 2011
BACKGROUND: Taurine (2-aminoethanesulfonic acid) is a semi-essential amino acid found in mammalian tissues that is not involved in protein synthesis. The function of taurine is not completely understood. Some studies have demonstrated that taurine supplementation reduces death rate in rabbits with heart failure (HF) and diminishes HF severity in human ...
Mendonca Goncalo V - - 2011
It has been shown that the fractal scaling properties of heart rate dynamics, in healthy aging, differ from that seen in heart disease and this favors the use of fluctuation measures as diagnostic tools. The purpose of this study was to evaluate the fractal heart rate dynamics in adults with ...
Alboni Paolo - - 2011
A feature of all air-breathing vertebrates, diving bradycardia is triggered by apnoea and accentuated by immersion of the face or whole body in cold water. Very little is known about the afferents of diving bradycardia, whereas the efferent part of the reflex circuit is constituted by the cardiac vagal fibres. ...
Brochet Eric - - 2011
BACKGROUND: In asymptomatic mitral stenosis (MS), the usefulness of peak exercise Doppler echocardiography (DE) values is acknowledged, but the role of values recorded during the first stage of DE remains unclear. METHODS: DE was analyzed in 48 asymptomatic patients with significant MS and revealed dyspnea in 22 patients (46%). RESULTS: ...
Mirtz Timothy A - - 2011
Children need physical activity and generally do this through the aspect of play. Active play in the form of organized sports can appear to be a concern for parents. Clinicians should have a general physiological background on the effects of exercise on developing epiphyseal growth plates of bone. The purpose ...
Wang Hao-Yan - - 2011
BACKGROUND: Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular problems. The symptom of dyspnea on exertion may be associated with COPD or heart failure or both. N-terminal-pro-BNP (NT-pro-BNP) is useful for indicating cardiac dysfunction, and an exercise test can find subtle abnormal conditions of the heart. The study ...
Nelson Matthew J - - 2011
The purpose of this study was to test the hypothesis that exercise-induced cardiac adaptations would be attenuated by the free radical scavenger N-2-mercaptopropionyl glycine (MPG). Male Sprague-Dawley rats were divided into four groups (9-13/group) for 3-4 weeks: sedentary (S), S+MPG (100 mg/kg IP daily), exercised on a treadmill (E) (60 ...
Lurz Philipp P Cardiovascular Unit, University College London Institute of Child Health, United Kingdom. - - 2011
The purpose of this study was to assess the potential of late positive functional remodeling after percutaneous pulmonary valve implantation (PPVI) in right ventricular outflow tract dysfunction. PPVI has been shown to impact acutely on biventricular function and exercise performance, but the potential for further late functional remodeling remains unknown. ...
Lewis Gregory D - - 2011
Elevated resting pulmonary arterial pressure (PAP) in patients with left ventricular systolic dysfunction (LVSD) purports a poor prognosis. However, PAP response patterns to exercise in LVSD and their relationship to functional capacity and outcomes have not been characterized. Sixty consecutive patients with LVSD (age 60±12 years, left ventricular ejection fraction ...
van Deel Elza D - - 2011
There is ample evidence that regular exercise exerts beneficial effects on left ventricular (LV) hypertrophy, remodeling and dysfunction produced by ischemic heart disease or systemic hypertension. In contrast, the effects of exercise on pathological LV hypertrophy and dysfunction produced by LV outflow obstruction have not been studied to date. Consequently, ...
Fu Tieh-Cheng - - 2011
This investigation elucidated the underlying mechanisms of functional impairments in patients with heart failure (HF) by simultaneously comparing cardiac-cerebral-muscle hemodynamic and ventilatory responses to exercise among HF patients with various functional capacities. One hundred one patients with HF [New York Heart Association HF functional class II (HF-II, n = 53) ...
Ascensão António - - 2011
Cardiac damage is a major contributor to the morbidity and mortality particularly associated with coronary artery disease. Moreover, it is also related to some metabolic diseases such as diabetes and to some side effects of drug treatments. Regular exercise has been confirmed as a pragmatic countermeasure to protect against cardiac ...
Kallistratos Manolis S - - 2011
High systolic blood pressure (SBP) has been linked to worse cardiovascular outcomes. However, emerging data suggest that in patients with heart failure (HF), low SBP correlates with increased mortality. The purpose was to examine the impact of baseline and post-exercise systolic and diastolic blood pressure (DBP), as well as pulse ...
de Oliveira Pires Flávio - - 2011
Objective To verify the effects of exercise intensity deception by the Borg scale on the ratings of perceived exertion (RPE), heart rate (HR) and performance responses during a constant power output open-loop exercise. Methods Eight healthy men underwent a maximal incremental test on a cycle ergometer to identify the peak ...
Teixeira Luiz - - 2011
Concurrent training is recommended for health improvement, but its acute effects on cardiovascular function are not well established. This study analyzed hemodynamics and autonomic modulation after a single session of aerobic (A), resistance (R), and concurrent (A + R) exercises. Twenty healthy subjects randomly underwent four sessions: control (C:30 min of rest), aerobic ...
Lin Qin-Qin - - 2011
Chronic heart failure (CHF) is often accompanied by renal dysfunction. Exercise training may relieve the symptomatic burden and improve the overall prognosis of CHF. In the present study, the effects of exercise training on renal function and renal aquaporin (AQP)-2 expression in CHF rats were examined to determine whether exercise ...
Ingle Lee - - 2011
AIMS: We studied the prognostic significance of the ventilatory equivalent of carbon dioxide production (VEqCO(2)) at different time-points of a maximal cardiopulmonary exercise test (CPET) in patients with suspected heart failure (HF). METHODS AND RESULTS: The VEqCO(2) was calculated at three different time-points; VEqCO(2) (rest) was calculated following 30 s ...
Cortopassi Felipe - - 2011
BACKGROUND: Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls. METHODS: We measured anthropometrics, lung function, respiratory muscle force, handgrip (HG) force and fat free mass (FFM) ...
Donal Erwan - - 2011
In aortic stenosis (AS), left ventricular (LV) adaptation to exercise has poorly been examined. Changes in LV ejection fraction may lack accuracy in identifying the presence of intrinsic myocardial impairment. AIMS: We sought to determine the impact of aortic stenosis (AS) on left ventricular (LV) longitudinal function at exercise in ...
Mendonca Goncalo V - - 2011
This study determined whether the cardiac autonomic function of adults with Down syndrome (DS) differs from that of nondisabled persons during submaximal dynamic exercise. Thirteen participants with DS and 12 nondisabled individuals performed maximal and submaximal treadmill tests with metabolic and heart rate (HR) measurements. Spectral analysis of HR variability ...
Lui George K - - 2011
Cardiopulmonary exercise testing is often used to evaluate exercise capacity in adults with congenital heart disease including women who are considering pregnancy. The relationship between cardiopulmonary exercise testing parameters and pregnancy outcome has not been defined. We conducted a multicenter retrospective observational study of women with congenital heart disease who ...
Trivedi Chinmay M - - 2011
Exercise induces growth of heart muscle cells and heart size. A new report in Cell (Boström et al., 2010) suggests that mice also respond to exercise with increased cardiac myocyte proliferation, and the molecular regulators of this pathway are linked to maladaptive and pathologic responses to cardiac stresses such as pressure ...
Valzania Cinzia - - 2011
AIMS: Myocardial contractile reserve (MCR) is a marker of myocardial viability. The impact of cardiac resynchronization therapy (CRT) on MCR during exercise has been little studied. Our aim was to investigate the effects of CRT on global and regional MCR by exercise echocardiography. METHODS AND RESULTS: Twenty-seven CRT responders (56% ...
Płazak Wojciech - - 2011
Background: Diastolic heart dysfunction, responsible for dyspnoea in heart failure patients, is an important prognostic factor. Patients with systemic sclerosis (SSc) serve as a model of diastolic heart failure with preserved ejection fraction. Aim: To quantify diastolic left ventricular (LV) dysfunction and elevation of pulmonary capillary wedge pressures (PCWP) in ...
Pressler Axel - - 2011
The influence of regular exercise on cardiac remodeling after aortic valve replacement (AVR) is virtually unknown. The case is reported of a 49-year-old male patient who had undergone biological valve replacement for severe aortic regurgitation with reduced left ventricular ejection fraction (LVEF; 45%) and massive left ventricular dilation (left ventricular ...
Roşca Monica - - 2011
Symptom development represents one of the most important indications for surgical intervention in patients with significant valvular heart disease. Exercise testing has an established role in the assessment of exercise capacity and symptomatic status in patients with severe valvular heart disease who claim to be asymptomatic. In these patients, clinical ...
Tandon Anumeha - - 2011
We present a case that demonstrates the rare occurrence of type 1 second-degree atrioventricular block (Wenckebach or Mobitz type 1 block) as a result of block in the infranodal conduction system. This extremely rare occurrence often predicts progression to complete heart block and necessitates cardiac pacing. It also demonstrates the ...
Sinning David - - 2011
Aims. Several mechanisms can be involved in the development of exercise intolerance in patients with heart failure despite normal left ventricular ejection fraction (HFNEF) and may include impairment of left ventricular (LV) stiffness. We therefore investigated the influence of LV stiffness, determined by pressure-volume loop analysis obtained by conductance catheterization, ...
Korzeniowska-Kubacka Iwona - - 2011
Background: The key to increase the percentage of cardiac patients undergoing cardiac rehabilitation is to follow a welldesigned exercise programme at home. To maximise the benefits while minimising the risks of aggravating health status, home-based exercise should be tele-monitored. Aim: To compare the effects on physical capacity and sympatho-vagal balance ...
Sales Marcelo M - - 2011
While several studies have identified the anaerobic threshold (AT) through the responses of blood lactate, ventilation and blood glucose others have suggested the response of the heart rate variability (HRV) as a method to identify the AT in young healthy individuals. However, the validity of HRV in estimating the lactate ...
Curren Michael - - 2011
Tissue Doppler imaging (TDI) has been a useful tool to evaluate of resting right ventricular (RV) function; however, the response of the RV to exercise has not been well established. This study attempts to determine RV mechanics at rest and immediately after exercise in healthy subjects using TDI and to ...
Haykowsky Mark - - 2011
The effects of variations in exercise training on left ventricular (LV) remodeling in patients shortly after myocardial infarction (MI) are important but poorly understood. Systematic review incorporating meta-analysis using meta-regression. Studies were identified via systematic searches of: OVID MEDLINE (1950 to 2009), Cochrane Central Register of Controlled Trials (1991 to ...
Vivodtzev Isabelle - - 2011
The endurance time (T(end)) during constant-workrate cycling exercise (CET) is highly variable in COPD. We investigated pulmonary and physiological variables that may contribute to these variations in T(end). Ninety-two patients with COPD completed a CET performed at 80% of peak workrate capacity (W(peak)). Patients were divided into tertiles of T(end) ...
Tanaka Hidekazu - - 2011
A 53-year-old man with depressed ejection fraction (EF) of 35% and QRS width of 88 ms at rest was admitted to our institution with a complaint of exertional chest discomfort and dyspnea. During treadmill exercise, left bundle-branch block (LBBB) with a QRS width of 152 ms occurred at a heart ...
Worringham Charles - - 2011
Despite its efficacy and cost-effectiveness, exercise-based cardiac rehabilitation is undertaken by less than one-third of clinically eligible cardiac patients in every country for which data is available. Reasons for non-participation include the unavailability of hospital-based rehabilitation programs, or excessive travel time and distance. For this reason, there have been calls ...
Pitsavos Christos - - 2011
We sought to investigate the effect of moderate physical exercise on left ventricular mass, exercise tolerance and blood pressure response during treadmill testing, in middle-aged pre-hypertensive and mildly hypertensive men without any evidence of coronary heart disease. Forty of 52 male borderline and mildly hypertensive subjects (mean age 53 ± ...
Nodari Savina - - 2010
OBJECTIVES: This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM). BACKGROUND: One hundred thirty-three patients with NICM and minimal symptoms on standard therapy were randomized to 2 g ...
Moreira-Gonçalves Daniel - - 2010
The present study evaluated the impact of moderate exercise training on the cardiac tolerance to acute pressure overload. Male Wistar rats were randomly submitted to exercise training or sedentary lifestyle for 14 weeks. At the end of this period, the animals were anaesthetized, mechanically ventilated and submitted to hemodynamic evaluation ...
Kühne Michael - - 2010
Aims The purpose of this study was to determine the effect of exercise on dyssynchrony in patients with left ventricular dysfunction. Methods and results Sixty patients with a left ventricular ejection fraction (LVEF) ≤35% were studied. Interventricular mechanical delay (IVMD), intraventricular mechanical delay [Ts-(lateral-septal)], and left ventricular filling ratio were ...
Kenttä Tuomas - - 2010
Aims Total cosine R-to-T (TCRT) measured from the standard 12-lead electrocardiogram (ECG) reflects the spatial relationship between depolarization and repolarization wavefronts and a low TCRT value is a marker of poor prognosis. We tested the hypothesis that measurement of TCRT or QRS/T angle from exercise ECG would provide even more ...
Bilet L - - 2011
Cardiac lipid accumulation is associated with decreased cardiac function and energy status (PCr/ATP). It has been suggested that elevated plasma fatty acid (FA) concentrations are responsible for the cardiac lipid accumulation. Therefore, the aim of the present study was to investigate if elevating plasma FA concentrations by exercise results in ...
Boström Pontus P Dana-Farber Cancer Institute, Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, MA 02115, - - 2010
The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process that could be of great importance for regenerative medicine. Using a ...
Al-Najjar Yahya - - 2010
BACKGROUND: Failure of the heart rate to rise normally during an incremental exercise test is termed chronotropic incompetence (CI). It is common in patients with chronic heart failure (CHF), and we wanted to explore the relation between CI and outcome in unselected patients with CHF. METHODS: 411 patients with left ...
Jaussaud Jérémie - - 2011
Background. Changes in peripheral muscle in heart failure lead to a shift from aerobic to early anaerobic metabolism during exercise leading to ergoreflex overactivation and exaggerated hyperventilation evaluated by the VE/VCO(2) slope. Methods. 50 patients (38 males, 59 ± 12 years) performed cardio-pulmonary exercise test with gaz exchange measurement and ...
Benito Begoña - - 2011
Recent clinical studies suggest that endurance sports may promote cardiac arrhythmias. The aim of this study was to use an animal model to evaluate whether sustained intensive exercise training induces potentially adverse myocardial remodeling and thus creates a potential substrate for arrhythmias. Male Wistar rats were conditioned to run vigorously ...
Ujeyl Amaar - - 2011
Conduction system disease and beta-blocker therapy are both common among heart failure (HF) patients and contribute to increasing reliance on paced rhythms. We hypothesized that many HF patients dependent on pacing have suboptimal heart rate responses and associated limitations in exercise capacity. We studied 122 HF patients (left ventricular ejection ...
Urell Charlotte - - 2010
Objective: In addition to early mobilisation, a variety of breathing exercises are used to prevent postoperative pulmonary complications after cardiac surgery. The optimal duration of the treatment is not well evaluated. The aim of this study was to determine the effect of 30 versus 10 deep breaths hourly, while awake, ...
Kwak Hyo-Bum - - 2011
Aging impairs function in the nonischemic heart and is associated with mechanical remodeling. This process includes accumulation of collagen (i.e., fibrosis) and dysregulation of active matrix metalloproteinases (MMPs). Exercise training (ET) improves cardiac function, but the pathways of protection remain poorly understood. Young (3 mo) and old (31 mo) FBNF1 ...
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