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Li Mengyao - - 2012
AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways ...
Dipla Konstantina - - 2012
This study aimed to assess the arterial pressure (AP) determinants during the muscle metaboreflex in boys and men and to investigate the contribution of baroreflex and sympathovagal function to the metaboreflex-induced responses. Fourteen pre-adolescent boys and 13 men performed a protocol involving: baseline, isometric handgrip exercise, circulatory occlusion, and recovery. ...
Karper William B - - 2012
In 2007, an article was published in this journal about the effects of exercise on two older men with fibromyalgia syndrome (FMS). This new article is an update on how exercise has affected them during a 4-year period since 2007. Results suggest that both these men still function at approximately ...
Lancellotti Patrizio - - 2012
The emerging role of stress and particularly exercise echocardiography in mitral regurgitation has been recently emphasized. In fact, the evaluation of mitral regurgitation only under resting conditions might underestimate the full impact of the lesion and its clinical effects. Exercise echocardiography can identify what otherwise might be considered as a ...
Basha P Mahaboob - - 2012
In previous studies, we investigated a link between high fluoride exposure and functional IQ deficits in rats. This study is an extension conducted to explore the combined influence of physical exercise and temperature stress on the learning ability and memory in rats and to assess whether any positive modulation could ...
Faiss Raphael - - 2012
PURPOSE: Slight differences in physiological responses and nitric oxide (NO) have been reported at rest between hypobaric hypoxia (HH) and normobaric hypoxia (NH) during short exposureOur study reports nitric oxide and oxidative stress at rest and physiological responses during moderate exercise in hypobaric hypoxia (HH) vs. normobaric hypoxia (NH). METHODS: ...
Gatterer H - - 2012
Reactive oxygen species are thought to partly be responsible for the hypoxia induced performance decrease. The present study evaluated the effects of a broad based antioxidant supplementation or the combined intake of alpha-ketoglutaric acid (α-KG) and 5-hydroxymethylfurfural (5-HMF) on the performance decrease at altitude. 18 healthy, well-trained males (age: 25±3 ...
Nyberg Michael - - 2012
Ageing has been proposed to be associated with increased levels of reactive oxygen species (ROS) that scavenge nitric oxide (NO). In eight young sedentary (23 ± 1 years; Y), eight older lifelong sedentary (66 ± 2 years; OS) and eight older lifelong physically active subjects (62 ± 2 years; OA), ...
Romeih Soha - - 2012
BACKGROUND: Patients with moderate pulmonary valve restenosis late after relief of severe pulmonary stenosis (PS) may show decreased exercise tolerance. To elucidate the mechanism of decreased exercise tolerance, we evaluated cardiac response to physical and pharmacological stress in these patients and compared results with those of patients with native moderate ...
Cardoso Christopher - - 2012
INTRODUCTION: Intranasal oxytocin attenuates cortisol levels during social stress inductions. However, no research to date has documented the dose-response relation between intranasal oxytocin administration and cortisol, and researchers examining intranasal oxytocin have not examined the cortisol response to physical stress. We therefore examined the effects of 24IU and 48IU of ...
Dekleva Milica - - 2012
An increase in reactive oxygen species has been implicated in the pathologies of hypertension. This study was designed to evaluate antioxidant activity in hypertensive patients and to assess the relationship between oxidative stress and exercise tolerance in hypertensive patients with mild left ventricular diastolic dysfunction (LVDD). A total of 42 ...
Rognmo Øivind - - 2012
Exercise performed at higher relative intensities has been found to elicit a greater increase in aerobic capacity and greater cardioprotective effects than exercise at moderate intensities. An inverse association has also been detected between the relative intensity of physical activity and the risk of developing coronary heart disease, independent of ...
Horckmans Michael - - 2012
Objective Nucleotides released within the heart under pathological conditions can be involved in cardioprotection or cardiac fibrosis through the activation P2Y(2) and P2Y(6) receptors, respectively. We demonstrated previously that adult P2Y(4)-null mice display a microcardia phenotype related to a cardiac angiogenic defect. To evaluate the functional consequences of this defect, ...
Roupas N D - - 2012
Exercise challenges homeostasis and establishes a new dynamic equilibrium. Elite Rhythmic Gymnasts (RG's) begin exercise at an early age, undergo physical and psychological stress, and adopt negative energy balance to retain a lean physique. The aim of the present study was to evaluate the effect of negative energy balance, acute ...
Djordjevic B - - 2012
The purpose of the current study was to examine the effect of Astaxanthin (Asx) supplementation on muscle enzymes as indirect markers of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players. Thirty-two male elite soccer players were randomly assigned in a double-blind fashion to Asx and ...
Hasan Babar Sultan - - 2012
This study assessed right ventricular (RV) and RV outflow tract (RVOT) function and pressure in response to exercise in patients with an obstructed RV-pulmonary artery (PA) conduit using exercise stress echocardiography (ESE) to evaluate these parameters. RV-PA conduits inevitably develop stenosis and/or regurgitation over time. Assessment of conduit obstruction only ...
Lima Mônica Cruvinel de - - 2012
To evaluate the influence of aerobic exercise on oxidative stress in mice. The study included twenty female mice Mus musculus-Swiss divided into two groups: sedentary control (GA) and exercise (GB), each containing ten animals. All animals underwent an adaptation period of seven days isolated in individual boxes. After this period, ...
Leite Hércules R - - 2012
Although it is well known that regular exercise may promote neuroprotection, the mechanisms underlying this effect are still not fully understood. We investigated if swim training promotes neuroprotection by potentiating antioxidant pathways, thereby decreasing the effects of oxidative stress on glutamate and nitric oxide release. Male Wistar rats (n=36) were ...
Lancellotti Patrizio - - 2012
BACKGROUND: Recent studies emphasized the usefulness of exercise stress echocardiography (ESE) in asymptomatic patients with aortic stenosis (AS). Nevertheless, the additive value of exercise pulmonary hypertension (Ex-PHT) in such patients remains unexplored. We, therefore, aimed to identify the determinants and to test the impact on outcome of Ex-PHT in asymptomatic ...
Baur D M - - 2012
BackgroundLow cardiorespiratory fitness (CRF) has been repeatedly linked to cardiovascular morbidity and mortality, while higher CRF levels are protective. This relationship is likely to be highly relevant in firefighters, who have increased risk of cardiovascular disease (CVD) mortality during strenuous emergencies, which can require prolonged periods of near-maximal heart rates ...
Medina Sonia - - 2012
The present study established the pattern of isoprostanes (IsoPs) and prostaglandins metabolites (PGMs) in urine after triathlon training. Fifteen Caucasian triathletes - 5 women and 10 men - performed 793 and 1603 Objective Load Scales, respectively. The optimization of urine hydrolysis conditions, concerning to the type of buffer, the units ...
Lurz Philipp P Centre for Cardiovascular Imaging, UCL Institute of Cardiovascular Science and Great Ormond Street Hospital for Children, London, UK. - - 2012
To assess the impact of relief of pulmonary stenosis (PS) and pulmonary regurgitation (PR) by percutaneous pulmonary valve implantation (PPVI) on biventricular function during exercise stress. Seventeen patients, who underwent PPVI for PS or PR, were included. Magnetic resonance imaging was performed at rest and during supine exercise stress pre- ...
Magne Julien - - 2012
AimThe exercise Doppler echocardiographic stress test can be of interest in the management of asymptomatic patients with primary mitral regurgitation (MR). The resting brain natriuretic peptide (BNP) level is a good surrogate marker of the consequences of MR and is a powerful predictor of outcome. The incremental prognostic value of ...
Sciolino Natale R NR Neuroscience Program, Biomedical and Health Sciences Institute, Department of Psychology, University of Georgia, Athens, GA 30602, United - - 2012
Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms that underlie the benefits of exercise. However, it is controversial whether exercise exerts anxiolytic-like potential in rodents. Evidence is reviewed to evaluate the effects of wheel running, ...
Jówko Ewa - - 2012
PURPOSE: To evaluate the effect of acute ingestion of green tea polyphenols (GTP) on blood markers of oxidative stress and muscle damage in soccer players exposed to intense exercise. METHODS: This randomized, double-blinded study was conducted on 16 players during a general preparation period, when all athletes participated in a ...
de Souza Priscila Soares - - 2012
AIM: To investigate the effects physical training exerts on markers of oxidative stress in rats with chronic kidney disease (CKD). MAIN METHODS: Twenty-four male Wistar rats were divided into four groups (n=6): sham, CKD, exercise-sham and exercise-CKD. Surgical reduction of the renal mass was performed (5/6 nephrectomized) and exercise was ...
McClelland Grant B - - 2012
Fish muscle responds to aerobic exercise training and cold acclimation with a more aerobic muscle phenotype than mammalian muscle but through both conserved and distinct molecular events. Differences from mammals in exercise metabolism and diversity in protein isoforms suggest that the regulation of muscle fuel use is more complex in ...
Braakhuis Andrea J - - 2012
Vitamin C is an essential component of the diet and may reduce the adverse effects of exercise-induced reactive oxygen species, including muscle damage, immune dysfunction, and fatigue. However, reactive oxygen species may mediate beneficial training adaptations that vitamin C attenuates; indeed, from a total of 12 studies, vitamin C in ...
Bossone Eduardo - - 2012
Exercise stress tests of the pulmonary circulation show promise for the detection of early or latent pulmonary vascular disease and may help us understand the clinical evolution and effects of treatments in patients with established disease. Exercise stresses the pulmonary circulation through increases in cardiac output and left atrial pressure. ...
Labsy Z - - 2012
Diurnal patterns of cortisol and dehydroepiandrosterone (DHEA) secretion, the two main peripheral secretory products of the hypothalamic-pituitary-adrenal neuroendocrine stress axis, have been well characterised in rest conditions but not in relation to physical exercise. The purpose of this investigation was therefore to determine the effects of an intense 90-minute aerobic ...
Lalande Sophie - - 2012
It has been suggested that shallow slopes of mean pulmonary artery pressure (MPPA)–cardiac output (Q) relationships and pulmonary transit of agitated contrast during exercise may be associated with a higher maximal aerobic capacity V(O(2)max). If so, individuals with a higher V(O(2)max) could also exhibit a higher pulmonary vascular distensibility and ...
Francica Juliana V - - 2012
The objective of the present study was to compare cardiovascular and autonomic responses to a mental stress test and to a maximal isometric exercise test between offspring of normotensive (ON, n = 10) and hypertensive parents (OH, n = 10). Subjects underwent a 3-min Stroop Color Word Test and a ...
Gibby Conrad - - 2012
AIMS: The diastolic stress test (DST) may facilitate the attribution of exertional dyspnoea to cardiac and non-cardiac diseases. However, there is currently no consensus as to the optimal marker of exertional diastolic dysfunction (DD)-the main alternatives being estimated left ventricular (LV) filling pressure (exercise E/e') and diastolic functional reserve (DFRI). ...
Jacobsen Paul B - - 2012
BACKGROUND: Research has shown that self-directed stress management training improves mental well-being in patients undergoing chemotherapy. The present study extends this work by evaluating separate and combined effects of stress management training and home-based exercise. METHOD: Following assessment of mental and physical well-being, depression, anxiety, exercise, and stress reduction activity ...
Drago-Serrano M-E - - 2012
The immune-suppression caused by acute stress can be reduced by a regular practice of moderate exercise which is known to modulate the expression of secretory-IgA. This antibody is essential for protection against infections and maintenance of homeostasis at the mucosal level. In order to explore the effects of moderate exercise ...
de Andrade Ch - - 2012
BACKGROUND: It is well established that the Work rate increment size affects the duration of test and physiological responses to exercise during cycling in patients with COPD. However, this has never been tested for incremental step tests. OBJECTIVE: To compare the exercise tolerance time, cardiopulmonary stress, and perception of effort ...
Melenovsky Vojtech - - 2012
AIMS: The goal of the study was to examine whether resting or post-exercise metabolic substrate levels are associated with differential exercise performance and long-term outcome in control subjects or heart failure (HF) patients with or without type 2 diabetes mellitus (DM). METHODS AND RESULTS: Twenty five healthy controls matched with ...
Silva Bruno M - - 2012
Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene reduce shear stress-induced nitric oxide production. Thus, we investigated the individual and combined impact of 3 variants in the NOS3 gene (-786T>C, intron 4b4a, and 894G>T) on vascular reactivity before and after exercise. Sedentary, healthy subjects were studied (105 women/26 men, ...
Cardim Nuno - - 2012
BACKGROUND: Treadmill exercise testing has low specificity for the detection of significant epicardial coronary artery disease (CAD). A possible mechanism to explain some of the false positives is transient subendocardial ischemia induced by intraventricular gradients (IVG) during stress. The development of IVG during dobutamine stress echocardiography (DSE) occurs in 8-38% ...
Stults-Kolehmainen Matthew A - - 2012
PURPOSE: The primary aim of this study was to determine whether chronic mental stress moderates recovery of muscular function, perceived energy, fatigue and soreness in the first hour following a bout of strenuous resistance exercise. METHODS: 31 undergraduate resistance training students (age = 20.26 ± 1.34 y) completed the perceived ...
Mehrotra Praveen - - 2012
BACKGROUND: Dobutamine and exercise echocardiography are well-validated modalities used for the evaluation of patients with suspected myocardial ischemia. Patients undergoing dobutamine stress echocardiography (DSE), however, experience less angina, ST-segment depressions, and wall motion abnormalities. Other than the effect on heart rate, the physiologic and volumetric differences between pharmacologic and exercise-induced ...
Packer Nicholas - - 2012
ABSTRACTAging is associated with increased intestinal inflammation and elevated risk of chronic diseases including inflammatory bowel diseases and colon cancer; many epidemiologic studies show that regular exercise reduces risk. This study examined the effects of long-term voluntary exercise on inflammatory mediators expressed in the intestine of older (15-16 months), healthy ...
Kordi Ramin - - 2012
The pathophysiology of primary benign exertional headache (EH) is not still clearly defined. Some researchers have suggested an impaired vascular response as the etiology of this disorder. In this study we investigated whether there are any differences in blood pressure (BP) and heart rate (HR) of the subjects in course ...
Jimenez Chantal - - 2012
Wearing protective clothing can have deleterious effects on operational capacities and can cause non-compensable thermal stress. We studied the effects of moderate exercise on orthostatic tolerance while wearing protective clothing in eight healthy subjects tolerant to orthostatism. Subjects performed a 60-min moderate exercise on a treadmill followed by a 45-min ...
Rai Balwant - - 2012
Extravehicular activity (EVA), such as exercise performed under unique environmental conditions, is essential for supporting daily living in weightlessness and for further space exploration like long Mars mission. The study was planned stress, workload, and physiological demands of simulated Mars exploration. In this study, the six-person crew lived (24 hours) ...
Périard Julien D - - 2012
This study examined whether a rise in thermal and cardiovascular strain during exercise to exhaustion in the heat at different intensities is associated with compromised muscle and cerebral oxygenation. Using near-infrared spectroscopy, oxygenation changes in the vastus lateralis and prefrontal cortex of ten subjects cycling to exhaustion in 40 °C conditions ...
Boscarino Cathy - - 2012
PURPOSE: To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS: Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossover study, as follows: Arm 4 consisted ...
Hida Satoshi - - 2012
Background: Although stress-induced left ventricular (LV) wall motion abnormality is a well-known marker for extensive coronary artery disease (CAD), no study has yet analyzed whether phase analysis of exercise-induced LV mechanical dyssynchrony may have enhanced diagnostic value over conventional perfusion analysis in the detection of multivessel CAD. Methods and Results: ...
Binder Konrad - - 2012
The purpose of this study was to examine arterial blood pressure responses during isometric handgrip (IHG) exercise performed at increasing levels of heat stress. Ten male subjects performed 1 min of IHG exercise at 60 % of maximal voluntary contraction under no heat stress (NHS), moderate heat stress [MHS, 0.6 °C increase in ...
Falkensammer Jürgen - - 2012
INTRODUCTION: Due to the systemic nature of atherosclerosis, the prevalence of coronary artery disease (CAD) is high in patients with peripheral arterial disease (PAD). A biochemical assay for assessing cardiac risk might improve clinical evaluation of PAD patients. The aim of this study was to investigate whether a new high-sensitivity ...
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