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Results 201 - 250 of 1112
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Anjos-Andrade Fernando Diego - - 2010
Although chronotropic incompetence (CI) represents an independent predictor of mortality and incidence of coronary artery disease, its pathophysiological mechanisms remain unknown. The purpose of this investigation was to evaluate wall motion abnormalities of the left ventricle and location of coronary arterial lesions in patients with and without CI. After exclusion ...
Vingren Jakob L - - 2010
Testosterone is one of the most potent naturally secreted androgenic-anabolic hormones, and its biological effects include promotion of muscle growth. In muscle, testosterone stimulates protein synthesis (anabolic effect) and inhibits protein degradation (anti-catabolic effect); combined, these effects account for the promotion of muscle hypertrophy by testosterone. These physiological signals from ...
Gläser Sven S Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Hospital Ferdinand-Sauerbruchstrasse, D-17475 Greifswald, Germany. - - 2010
Insulin-like growth factor I (IGF-I) and its binding protein 3 (IGFBP-3) are central mediators of endocrine effects of growth hormone and there is increasing evidence for an association with muscle strength and exercise capacity. The aim of the present study was to clarify the possible association of circulating IGF-I and ...
Lai Fu-Chih - - 2010
AIMS:: To determine whether a home-based exercise program is able to increase functional capacity (FC) and reduce heart rate variability (HRV) in postmenopausal women with coronary heart disease. BACKGROUND:: Regular exercise training has been shown to improve both FC and HRV. However, those studies were conducted within institutional training programs, ...
Rojas Vega S - - 2010
Studies have shown that, depending on intensity, endurance exercise increases neurotrophins and thereby induces neuroplasticity. However, data on the effect of acute resistance exercise at different intensities on neurotrophins is not yet available. Thus, we conducted 2 trials to determine the serum concentrations of brain-derived neurotrophic factor (BDNF), vascular endothelial ...
Sartorio A - - 2010
Pharmacological or exercise stimuli repeated at a short interval (but not electrical muscle stimulation) are associated with a blunting of GH responsiveness. To compare GH responses to repeated bout of three different GH-releasing stimuli. The effects of two consecutive bouts (with a 2-h interval) of whole body vibrations (WBV), maximal ...
Pullinen T - - 2011
It was hypothesized that exercise-induced muscle damage (EIMD)-related alterations in hormonal responses could be observed if a second exercise bout is performed soon after an identical unaccustomed bout leading to delayed onset muscle soreness (DOMS). Eight men (31 ± 7 years) and eight boys (14 ± 0 years) performed two ...
Newman Connie B - - 2011
Data regarding effects of lower-dose GH on cardiopulmonary function in GH-deficient (GHD) adults are limited. The objective was to assess effects of lower-dose GH on exercise capacity and echocardiographic parameters in GHD adults. The study was a 6-month double-blind, placebo-controlled randomized trial. The study was conducted at the General Clinical ...
Baillot A - - 2011
The aim of this study was to evaluate serum and saliva adrenocortical hormones and their relationships at rest and during submaximal exercise and recovery in 9 obese diabetic middle-aged men (BMI: 35.2±1.6 kg/m (2)). Blood and saliva samples were taken at rest, every 10 min of a 30-min cycling exercise ...
Huffman Kim M KM Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA. - - 2011
To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. Targeted mass spectrometry and enzyme-linked immunosorbent assays were used to quantify metabolic intermediates, hormones, and inflammatory markers at baseline, after 6 months of exercise training, and 2 ...
Thomas N E - - 2010
The aim of this study was to examine the effect of supra-maximal exercise on circulating concentrations of salivary testosterone, salivary cortisol, and salivary immunoglobulin A in female adolescents. Nineteen apparently healthy females aged 15-16 years participated in this study. All participants completed 668 s sprints, interspersed with 30 s recovery ...
West Daniel W D - - 2010
Testosterone supplementation acts via numerous mechanisms as a highly potent anabolic agent to skeletal muscle. Although growth hormone (GH) strongly affects collagen synthesis and lipolysis, as well as increasing lean body mass, it is not anabolic toward the contractile (ie, myofibrillar) muscle tissue in healthy individuals. However, there is a ...
Salvadori Alberto - - 2010
Background  Growth hormone (GH) secretion is normally sensitive to physical exercise. Intensity and duration of exercise, fitness and age can all influence the GH response to exercise. In obesity, GH secretion is decreased both in basal conditions and in response to exercise. Objective  To analyse the dynamics of GH response ...
Botega Fernando de Souza Fde - - 2010
The aim of the present study was to assess the behavior of cardiovascular variables during an in-hospital cardiovascular rehabilitation program in patients following myocardial revascularization surgery. A total of 14 patients (mean age: 55.4 ± 6.4 years, 78.6% male) participated in the study, all of whom had a previous diagnosis ...
Ghisi Gabriela Lima de Melo - - 2010
The role of the endothelium was considered mainly as a selective barrier for the diffusion of macromolecules from the lumen of blood vessels to the interstitial space. During the last 20 years, many other functions have been defined for the endothelium, such as the regulation of the vagal tonus, the ...
Schwindt Christina D - - 2010
Inhaled corticosteroids (ICS) improve symptoms in lung diseases, such as asthma. Initial data suggest that the effects of ICS remain localized in the lung; however, recent studies demonstrate alteration to the peripheral immune system in patients with asthma. We sought to evaluate the effect of ICS on peripheral immune mediators ...
Matsuse Hiroo - - 2010
Resistance exercise is a physiological stimulus for acute increases in growth hormone (GH) secretion, and it also causes lactate accumulation and stimulates norepinephrine (NE) secretion as a sympathetic nervous response. The hybrid exercise method (HYB) is a novel resistance exercise method that combines a voluntary concentric muscle contraction and an ...
Wahl Patrick - - 2010
The purpose of the present study was to examine the acute hormonal response of a short term high-intensity training (HIT) versus a high volume endurance training (HVT) and to determine the contribution of the metabolic acidosis as a stimulus for possibly different reactions of circulating hGH, IGF-1, IGFBP-3 and cortisol. ...
Dudgeon Wesley David - - 2010
Exercise has the potential to impact disease by altering circulating anabolic and catabolic factors. It was the goal of this study to determine how different regimens of low-intensity and moderate-intensity exercise affected circulating levels of these anabolic and catabolic factors in HIV-infected men. Exercise-naive, HIV-infected men, medically cleared for study ...
Fatouros Ioannis - - 2010
Exercise is a paradigm of a stress situation. The adaptive response to stressors comprises the activation of the hypothalamic-pituitary-adrenal (HPA) axis and components of the autonomic sympathetic system. An aseptic inflammatory reaction is triggered by exercise, involving the stimulation of the so-called proinflammatory cytokines, such as tumor necrosis factor α ...
Pichini Simona - - 2010
Indirect biomarkers of recombinant human growth hormone (rhGH), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulin-like growth factor binding proteins (IGFBP-2 and IGFBP-3) and insulin (C-peptide) were measured together with urinary parameters of renal damage (beta(2)-microglobulin and proteinuria) by immunoassays, in house validated for the purpose, in 61 subjects ...
Rahimi Rahman - - 2010
The effect of 3 different rest periods on the acute hormonal responses to resistance exercise (RE) was examined in 10 experienced resistance trained men (age: 20.37 +/- 2.24 years, weight: 65.5 +/- 26.70 kg). On 3 separate sessions of an RE protocol, subjects were assigned in a random order a ...
Kon Michihiro - - 2010
INTRODUCTION: Several recent studies have shown that resistance exercise combined with vascular occlusion effectively causes increases in muscular size and strength. Researchers speculated that the vascular occlusion-induced local hypoxia may contribute to the adaptations via promoting anabolic hormone secretions stimulated by local accumulation of metabolic subproducts. Here, we examined whether ...
Vendelbo Mikkel H - - 2010
CONTEXT: GH secretion is increased by stress, such as fasting and exercise. OBJECTIVE: Our study was designed to test the hypothesis that fasting and exercise increase GH levels, GH-dependent signal transducer and activator of transcription (STAT)-5b phosphorylation, and IGF-I mRNA levels in human skeletal muscle. DESIGN AND PARTICIPANTS: Eight healthy ...
Charro M A - - 2010
The purpose of the present study was to compare the effect of different resistance training systems (Multiple-set [MS] and Pyramid [P]) on hormonal, metabolic and perceptual markers of internal load. Ten healthy men performed two resistance training sessions (MS and P) which consisted of three exercises (bench press, peck deck ...
Madarame H - - 2010
To compare endocrine responses to low-intensity resistance exercise with blood flow restriction (BFR) for upperlimb (UL) and lower-limb (LL) muscles, we measured blood lactate, plasma noradrenaline, and serum growth hormone (GH), testosterone, cortisol and insulin-like growth factor-I (IGF-I) before and after the UL (biceps curl and triceps press down) and ...
Beaven C Martyn - - 2010
Testosterone and cortisol respond to exercise stimuli and modulate adaptation. Episodic basal secretion of these hormones may modify the responsiveness of these hormones. We sought to identify episodic steroid secretion via frequent salivary sampling and investigate any interaction between ultradian rhythmicity and induced changes in testosterone. Salivary testosterone and cortisol ...
Ben Ounis O - - 2011
The aim of this study was to characterize the resting levels of cortisol and growth hormone (GH), and the substrate profile during exercise of obese children before and after an individualized training program. Twenty-two obese children (13.1±0.8 yrs) were included in the study. Twelve individuals (six boys and six girls; 31.1±1.1kg/m(2), ...
Stokes Keith A - - 2010
Exercise stimulates growth hormone (GH) release, but there are conflicting reports regarding the acute effects of exercise on circulating ghrelin and insulin-like growth factor (IGF) concentrations. This investigation examined (1) the effect of a single sprint on circulating GH, ghrelin and IGF concentrations as well as a marker of IGF-I ...
Ruiz Jonatan R - - 2010
The aim of this study was to determine the effect of a 16-week intrahospital supervised, conditioning program including both resistance and aerobic type training on insulin-like growth factors 1 and 2 (IGF-1, IGF-2), several IGF-binding proteins (IGFBPs), and growth hormone (GH) in children receiving treatment against acute lymphoblastic leukemia (ALL). ...
Nindl Bradley C - - 2010
Insulin-like growth factor-I (IGF-I) is regulated by a number of IGF-binding proteins (IGFBPs) and proteases that influence IGF-I bioactivity. A specific IGF-I kinase receptor activation assay (KIRA) has been developed that determines the ability of IGF-I to activate the IGF-I receptor by quantification of intracellular receptor autophosphorylation on IGF-I binding. ...
Zajac Adam - - 2010
This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes. The subjects were randomly divided between a placebo ...
Birzniece Vita - - 2010
Human growth hormone (GH) is widely abused by athletes; however, there is little evidence that GH improves physical performance. Replacement of GH in GH deficiency improves some aspects of exercise capacity. There is evidence for a protein anabolic effect of GH in healthy adults and for increased lean body mass ...
Viru M - - 2010
The purpose of this study was to explore the mechanisms for increased exercise performance in conditions of competition. Endurance trained subjects (n=14) performed incremental treadmill running to exhaustion in control laboratory conditions (non-competition) and in conditions of simulated competition to assess performance (running duration). Heart rate and respiration gases were ...
Rahman Zamzy A - - 2010
The aim of the present study was to assess the levels of salivary cortisol, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) before, during and after acute exercise. Acute exercise was induced using a standard treadmill test with Bruce protocol in ten physically active male participants. Unstimulated saliva was collected ...
Oosthuyse Tanja - - 2010
The female hormones, oestrogen and progesterone, fluctuate predictably across the menstrual cycle in naturally cycling eumenorrhoeic women. Other than reproductive function, these hormones influence many other physiological systems, and their action during exercise may have implications for exercise performance. Although a number of studies have found exercise performance - and ...
Krogh Jesper - - 2010
A blunted growth hormone and prolactin response to pharmacological stress test have previously been found in depressed patients, as well as an increased cortisol response to psychosocial stress. This study investigated these hormones in response to acute exercise using an incremental bicycle test. A cross-sectional comparison of cortisol, growth hormone, ...
Coiro Vittorio - - 2010
OBJECTIVE: To evaluate whether prolonged physical activity (25 km/week running for 8 years) modifies GH decline. DESIGN: The GH response to maximal exercise on bicycle-ergometer was tested in younger (26-30 years) and older (42-46 years) healthy women. Each age group included 2 subgroups of 10 sedentary and 10 runners, which ...
Jenni S - - 2010
AIMS: To compare exercise-induced growth hormone (GH) response in patients with Type 1 diabetes during stable euglycaemic and hyperglycaemic conditions. METHODS: We conducted a randomized, controlled, single-blinded cross-over trial in seven male patients with well-controlled Type 1 diabetes. The patients cycled twice for 120 min at a level of 55-60% ...
Seo Dong-Il - - 2010
BACKGROUND: The purpose of this study was to examine the effects of combined exercise training on growth hormone (GH), insulin-like growth factor-1 (IGF-1), and metabolic-syndrome factors and determine whether the changes in GH and/or IGF-1 induced by exercise correlate to the metabolic-syndrome factors in healthy middle-aged women (50-65 years of ...
Phillips Melody D MD Texas Christian University, Exercise Physiology Laboratory, Fort Worth, TX 76123, USA. - - 2010
Inflammatory cytokines are associated with age- and inactivity-related diseases. We examined the influence of moderate- to high-intensity resistance trainings (RT) on inflammatory cytokines (interleukin 6 (IL-6) and 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha)) in circulation and lipopolysaccharide (LPS)-stimulated whole blood in elderly women. Previously sedentary women (72 +/- ...
Michaelides Andreas P - - 2010
Objectives. Mitral valve prolapse (MVP) is a known cause for false positive exercise test (ET). The purpose of this study was to establish additional electrocardiographic criteria to distinguish the false positive exercise results in patients with MVP. Methods. We studied 218 consecutive patients (53 ± 6 years, 103 males) with ...
Eliakim Alon - - 2010
The effect of exercise training on anabolic hormones and inflammatory mediators is particularly important during childhood and puberty, since during this period there is a spontaneous increase in anabolic hormones that leads to the marked puberty-related growth spurt. Therefore, any training-associated hormonal and/or inflammatory effect during this critical period may ...
Frystyk Jan - - 2010
Exercise is a robust physiological stimulator of the pituitary secretion of growth hormone (GH), and within approximately 15 min after the onset of exercise, plasma GH starts to increase. GH and its primary downstream mediator, insulin-like growth factor I (IGF-I), play a critical role in formation, maintenance, and regeneration of ...
Nishida Yuichiro - - 2010
Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, ...
Nindl Bradley C - - 2010
The underlying mechanisms responsible for mediating the beneficial outcomes of exercise undoubtedly are many, but the insulin-like growth factor-I (IGF-I) system is emerging as an important and central hormonal axis that plays a significant role concerning cellular anabolism. This introductory article summarizes the intent and the content for papers presented ...
Ross Rebecca L - - 2010
Mounting evidence suggests fibromyalgia (FM) symptoms are influenced by dysfunction of the hypothalamic-pituitary-hormonal axes (HPHA) and the immune response system. The predominant FM symptoms of widespread pain, fatigue, sleep disturbance, depression, stiffness and exercise intolerance are related to abnormal levels of growth hormone (GH) and are reminiscent of "sickness behavior"; ...
Migiano Matthew J - - 2010
Rehabilitation programs and research experiments use single-arm protocols in which the contralateral arm is not functional or used as a control limb. This study was interested in determining the hormonal signal impacts of such one- versus two-arm exercise responses that might have an impact on adaptational changes with training. The ...
Hills Andrew P - - 2010
An understanding of physical growth and maturation is relevant to many disciplines, including exercise and sport science, anthropology, human biology, medicine, psychology and education. Growth and maturation is governed by a complex interaction between genetic and environmental factors. There is increasing evidence that physical activity plays an important role in ...
Nindl Bradley C - - 2010
Whereas there are many varied roles of insulin-like growth factor I (IGF-I), and it exists in different biocompartments, there is abundant scientific evidence demonstrating that IGF-I is an important metabolic biomarker associated with a variety of health- and exercise-related outcomes. In most cases (muscle, bone, tendon, body composition, and cognitive ...
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