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Mortensen Stefan P - - 2011
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To gain insight into the mechanisms by which ATP is released ...
Robles Juan Carlos - - 2011
Exercise training enhances endothelium-dependent coronary vasodilatation, improving perfusion and contractile function of collateral-dependent myocardium. Paradoxically, studies from our laboratory have revealed increased Ca(2+)-dependent basal active tone in collateral-dependent arteries of exercise-trained pigs. In this study, we tested the hypothesis that exercise training enhances agonist-mediated contractile responses of collateral-dependent arteries by ...
Casey Darren P - - 2011
We previously demonstrated that nitric oxide (NO) contributes to compensatory vasodilation in the contracting human forearm subjected to acute hypoperfusion. We examined the potential role of an adenosine-NO interaction to this response in 17 male subjects (25 ± 2 yr). In separate protocols subjects performed rhythmic forearm exercise (20% of ...
Shon Soo-Min - - 2011
Few studies have investigated if exercise by itself has anti-atherosclerotic effects, without combining interventions with a low-fat diet. We studied the effects of exercise as a stand-alone intervention on preexisting atheromata by measuring not only plaque size but also the levels of plaque-destabilizing matrix-metalloproteinase (MMP) activity in vivo. We used ...
Headley Samuel A - - 2011
Headley, SA, Henry, K, Nindl, BC, Thompson, BA, Kraemer, WJ, and Jones, MT. Effects of lifting tempo on one repetition maximum and hormonal responses to a bench press protocol. J Strength Cond Res 25(2): 406-413, 2011-This study was carried out in 2 parts: part 1 was designed to measure the ...
Goto Kazushige - - 2011
Goto, K, Maemura, H, Takamatsu, K, and Ishii, N. Hormonal responses to resistance exercise after ingestion of carnosine and anserine. J Strength Cond Res 25(2): 398-405, 2011-Intramuscular carnosine buffers protons (H) in skeletal muscle. We examined the effects of supplementation with chicken breast meat extract (CBEX) containing carnosine and anserine ...
Gonzales Joaquin U - - 2011
Skeletal muscle contractions are associated with physical stimuli that act upon muscle vasculature, including increased shear stress and blood pressure. It is unclear if acute dynamic exercise alters local vascular function. The purpose of this study was to examine the role of exercise hemodynamics on the effects of acute exercise ...
Goss Fredric L - - 2011
This investigation identified a perceptually-based "warning zone" that can be used to anticipate termination of treadmill tests administered to individuals taking beta-blockers. The use of ratings of perceived exertion to anticipate test termination may be valuable given the attenuation of heart rate associated with the use of this class of ...
Mahler Donald A - - 2011
Abstract BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) exhibit greater oxyhemoglobin desaturation during walking than with cycling. The purpose of this investigation was to investigate differences in ventilatory responses and gas exchange as proposed mechanisms for this observation. METHODS: Arterial blood gases and lactate were measured in 12 patients ...
Laksmivenkateshiah Srinivas - - 2011
OBJECTIVES: To examine the utility of decline in arterial partial pressure of oxygen after exercise as a marker of pulmonary vascular obstructive disease in patients with atrial septal defect and pulmonary hypertension. METHODS: Treadmill exercise was performed in 18 patients with atrial septal defect and pulmonary hypertension. Arterial blood gas ...
Padilla Jaume - - 2011
Aging has been recently associated with increased retrograde and oscillatory shear in peripheral conduit arteries, a hemodynamic environment that favors a proatherogenic endothelial cell phenotype. We evaluated whether nitric oxide (NO) bioavailability in resistance vessels contributes to age-related differences in shear rate patterns in upstream conduit arteries at rest and ...
Dean Abigail S - - 2011
PURPOSE:: Peripheral vascular abnormalities contribute to compromised functional status in heart failure (HF) patients. The purpose of the present study was to test whether the intervention of moderate-intensity, resistance training could improve peripheral vascular responsiveness, that is, flow-mediated dilation (FMD) in HF. METHODS:: Baseline brachial artery FMD analysis (2 minutes ...
Phillips Shane A - - 2011
Resistance and aerobic exercise is recommended for cardiovascular health and disease prevention. However, the accompanying increase in arterial pressure during resistance exercise may be detrimental to vascular health. This study tests the vascular benefits of aerobic compared with resistance exercise on preventing impaired vascular function induced by a single weight ...
Cho Eun Jeung - - 2011
Type III hyperlipoproteinemia is a rare familial disease characterized by marked elevations of serum cholesterol and triglyceride levels caused by an accumulation of remnant lipoproteins in apolipoprotein E2/E2 homozygotes. It is associated with an increased risk for premature atherosclerotic vascular disease. A 55-year-old woman was diagnosed as having type III ...
Hurren Nicholas M - - 2011
Preprandial aerobic exercise lowers postprandial lipaemia (a risk factor for coronary heart disease), however, the mechanisms responsible are still not clear. This study investigated whether blood flow to skeletal muscle and/or the liver was increased in the postprandial period after exercise, relative to a control trial, and whether this resulted ...
Seeger J P H - - 2011
Children with diabetes mellitus type 1 (DM1) demonstrate endothelial dysfunction and mild artery wall thickening compared to their age-matched healthy peers. In this study, we examined the effect of 18-week exercise training on physical fitness, and vascular function and structure in children with DM1. We examined physical fitness, brachial artery ...
Wray D Walter - - 2011
In the peripheral circulation, nitric oxide (NO) is released in response to shear stress across vascular endothelial cells. We sought to assess the degree to which NO contributes to exercise-induced vasodilation in the brachial artery (BA) and to determine the potential of this approach to noninvasively evaluate NO bioavailability. In ...
Ghaffari Samad - - 2011
Background: Slow heart rate recovery (HRR) after exercise is considered to represent impaired parasympathetic tone and to be a predictor of all-cause and cardiovascular mortality, but the independent value of abnormal HRR in predicting the presence and severity of coronary artery disease (CAD) is unknown. The aim of this study ...
Cesar Liliana - - 2011
Diet and exercise promote cardiovascular health but their relative contributions to atherosclerosis are not fully known. The transition from a sedentary to active lifestyle requires increased caloric intake to achieve energy balance. Using atherosclerosis-prone ApoE-null mice we sought to determine whether the benefits of exercise for arterial disease are dependent ...
Nickel Kevin J - - 2011
The effects of acute exercise on arterial compliance in older adults are unknown. Large and small arterial compliance were assessed during and 24 hours following a 30-minute bicycle ergometer test and on a nonexercise, control condition. The change in large artery compliance was similar between the exercise and nonexercise conditions ...
Casey Darren P - - 2011
Hypoxic vasodilation in skeletal muscle at rest is known to include β-adrenergic receptor-stimulated nitric oxide (NO) release. We previously reported that the augmented skeletal muscle vasodilation during mild hypoxic forearm exercise includes β-adrenergic mechanisms. However, it is unclear whether a β-adrenergic receptor-stimulated NO component exists during hypoxic exercise. We hypothesized ...
Nishiwaki Masato - - 2010
The objective of this study was to examine the effects of exercise training in hypoxia on arterial stiffness and flow-mediated vasodilation (FMD) in postmenopausal women. Sixteen postmenopausal women (56 ± 1 years) were assigned to a normoxic exercise group (Normoxic group, n = 8) or a hypoxic exercise group (Hypoxic group, n = 8). The Hypoxic group ...
Piira Olli-Pekka - - 2010
The incidence of adverse cardiovascular events is higher among spectators of exciting sports events, but the mechanistic link between the events is not known. We assessed the heart rate (HR) and blood pressure (BP) dynamics of enthusiastic male ice hockey spectators (60±9years) with coronary artery disease (CAD) during Finnish national ...
Flox-Camacho Angela - - 2011
Ergospirometry objectively quantifies exercise capacity. Up until now, the response to exercise evaluated by ergospirometry in patients with pulmonary arterial hypertension has only been described in recently diagnosed.patients. Our aim is to describe the response to exercise in patients with severe pulmonary arterial hypertension under specific treatment and define which ...
Fraser J A V - - 2011
Hyperoxia has been shown to attenuate the increase in pulmonary artery (PA) pressure associated with immersed exercise in thermoneutral water, which could serve as a possible preventive strategy for the development of immersion pulmonary edema (IPE). We tested the hypothesis that the same is true during exercise in cold water. ...
Naylor Louise H - - 2011
This study aimed to determine the importance of repeated increases in blood flow to conduit artery adaptation, using an exercise-independent repeated episodic stimulus. Recent studies suggest that exercise training improves vasodilator function of conduit arteries via shear stress-mediated mechanisms. However, exercise is a complex stimulus that may induce shear-independent adaptations. ...
Figueroa Arturo - - 2011
Exercise with whole-body vibration (WBV) decreases brachial-ankle pulse wave velocity (baPWV), a marker of systemic arterial stiffness. To examine the effect of WBV on arterial responses, 12 young men underwent three experimental trials: (1) no-exercise control (CON), (2) static squat with WBV, and (3) static squat without WBV (no-WBV). Bilateral ...
Anjos-Andrade Fernando Diego - - 2010
Although chronotropic incompetence (CI) represents an independent predictor of mortality and incidence of coronary artery disease, its pathophysiological mechanisms remain unknown. The purpose of this investigation was to evaluate wall motion abnormalities of the left ventricle and location of coronary arterial lesions in patients with and without CI. After exclusion ...
Vingren Jakob L - - 2010
Testosterone is one of the most potent naturally secreted androgenic-anabolic hormones, and its biological effects include promotion of muscle growth. In muscle, testosterone stimulates protein synthesis (anabolic effect) and inhibits protein degradation (anti-catabolic effect); combined, these effects account for the promotion of muscle hypertrophy by testosterone. These physiological signals from ...
Gläser Sven S Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Hospital Ferdinand-Sauerbruchstrasse, D-17475 Greifswald, Germany. - - 2010
Insulin-like growth factor I (IGF-I) and its binding protein 3 (IGFBP-3) are central mediators of endocrine effects of growth hormone and there is increasing evidence for an association with muscle strength and exercise capacity. The aim of the present study was to clarify the possible association of circulating IGF-I and ...
Lai Fu-Chih - - 2010
AIMS:: To determine whether a home-based exercise program is able to increase functional capacity (FC) and reduce heart rate variability (HRV) in postmenopausal women with coronary heart disease. BACKGROUND:: Regular exercise training has been shown to improve both FC and HRV. However, those studies were conducted within institutional training programs, ...
Rojas Vega S - - 2010
Studies have shown that, depending on intensity, endurance exercise increases neurotrophins and thereby induces neuroplasticity. However, data on the effect of acute resistance exercise at different intensities on neurotrophins is not yet available. Thus, we conducted 2 trials to determine the serum concentrations of brain-derived neurotrophic factor (BDNF), vascular endothelial ...
Sartorio A - - 2010
Pharmacological or exercise stimuli repeated at a short interval (but not electrical muscle stimulation) are associated with a blunting of GH responsiveness. To compare GH responses to repeated bout of three different GH-releasing stimuli. The effects of two consecutive bouts (with a 2-h interval) of whole body vibrations (WBV), maximal ...
Pullinen T - - 2011
It was hypothesized that exercise-induced muscle damage (EIMD)-related alterations in hormonal responses could be observed if a second exercise bout is performed soon after an identical unaccustomed bout leading to delayed onset muscle soreness (DOMS). Eight men (31 ± 7 years) and eight boys (14 ± 0 years) performed two ...
Newman Connie B - - 2011
Data regarding effects of lower-dose GH on cardiopulmonary function in GH-deficient (GHD) adults are limited. The objective was to assess effects of lower-dose GH on exercise capacity and echocardiographic parameters in GHD adults. The study was a 6-month double-blind, placebo-controlled randomized trial. The study was conducted at the General Clinical ...
Baillot A - - 2011
The aim of this study was to evaluate serum and saliva adrenocortical hormones and their relationships at rest and during submaximal exercise and recovery in 9 obese diabetic middle-aged men (BMI: 35.2±1.6 kg/m (2)). Blood and saliva samples were taken at rest, every 10 min of a 30-min cycling exercise ...
Huffman Kim M KM Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA. - - 2011
To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. Targeted mass spectrometry and enzyme-linked immunosorbent assays were used to quantify metabolic intermediates, hormones, and inflammatory markers at baseline, after 6 months of exercise training, and 2 ...
Thomas N E - - 2010
The aim of this study was to examine the effect of supra-maximal exercise on circulating concentrations of salivary testosterone, salivary cortisol, and salivary immunoglobulin A in female adolescents. Nineteen apparently healthy females aged 15-16 years participated in this study. All participants completed 668 s sprints, interspersed with 30 s recovery ...
West Daniel W D - - 2010
Testosterone supplementation acts via numerous mechanisms as a highly potent anabolic agent to skeletal muscle. Although growth hormone (GH) strongly affects collagen synthesis and lipolysis, as well as increasing lean body mass, it is not anabolic toward the contractile (ie, myofibrillar) muscle tissue in healthy individuals. However, there is a ...
Salvadori Alberto - - 2010
Background  Growth hormone (GH) secretion is normally sensitive to physical exercise. Intensity and duration of exercise, fitness and age can all influence the GH response to exercise. In obesity, GH secretion is decreased both in basal conditions and in response to exercise. Objective  To analyse the dynamics of GH response ...
Botega Fernando de Souza Fde - - 2010
The aim of the present study was to assess the behavior of cardiovascular variables during an in-hospital cardiovascular rehabilitation program in patients following myocardial revascularization surgery. A total of 14 patients (mean age: 55.4 ± 6.4 years, 78.6% male) participated in the study, all of whom had a previous diagnosis ...
Ghisi Gabriela Lima de Melo - - 2010
The role of the endothelium was considered mainly as a selective barrier for the diffusion of macromolecules from the lumen of blood vessels to the interstitial space. During the last 20 years, many other functions have been defined for the endothelium, such as the regulation of the vagal tonus, the ...
Schwindt Christina D - - 2010
Inhaled corticosteroids (ICS) improve symptoms in lung diseases, such as asthma. Initial data suggest that the effects of ICS remain localized in the lung; however, recent studies demonstrate alteration to the peripheral immune system in patients with asthma. We sought to evaluate the effect of ICS on peripheral immune mediators ...
Matsuse Hiroo - - 2010
Resistance exercise is a physiological stimulus for acute increases in growth hormone (GH) secretion, and it also causes lactate accumulation and stimulates norepinephrine (NE) secretion as a sympathetic nervous response. The hybrid exercise method (HYB) is a novel resistance exercise method that combines a voluntary concentric muscle contraction and an ...
Wahl Patrick - - 2010
The purpose of the present study was to examine the acute hormonal response of a short term high-intensity training (HIT) versus a high volume endurance training (HVT) and to determine the contribution of the metabolic acidosis as a stimulus for possibly different reactions of circulating hGH, IGF-1, IGFBP-3 and cortisol. ...
Dudgeon Wesley David - - 2010
Exercise has the potential to impact disease by altering circulating anabolic and catabolic factors. It was the goal of this study to determine how different regimens of low-intensity and moderate-intensity exercise affected circulating levels of these anabolic and catabolic factors in HIV-infected men. Exercise-naive, HIV-infected men, medically cleared for study ...
Fatouros Ioannis - - 2010
Exercise is a paradigm of a stress situation. The adaptive response to stressors comprises the activation of the hypothalamic-pituitary-adrenal (HPA) axis and components of the autonomic sympathetic system. An aseptic inflammatory reaction is triggered by exercise, involving the stimulation of the so-called proinflammatory cytokines, such as tumor necrosis factor α ...
Pichini Simona - - 2010
Indirect biomarkers of recombinant human growth hormone (rhGH), insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II), insulin-like growth factor binding proteins (IGFBP-2 and IGFBP-3) and insulin (C-peptide) were measured together with urinary parameters of renal damage (beta(2)-microglobulin and proteinuria) by immunoassays, in house validated for the purpose, in 61 subjects ...
Rahimi Rahman - - 2010
The effect of 3 different rest periods on the acute hormonal responses to resistance exercise (RE) was examined in 10 experienced resistance trained men (age: 20.37 +/- 2.24 years, weight: 65.5 +/- 26.70 kg). On 3 separate sessions of an RE protocol, subjects were assigned in a random order a ...
Kon Michihiro - - 2010
INTRODUCTION: Several recent studies have shown that resistance exercise combined with vascular occlusion effectively causes increases in muscular size and strength. Researchers speculated that the vascular occlusion-induced local hypoxia may contribute to the adaptations via promoting anabolic hormone secretions stimulated by local accumulation of metabolic subproducts. Here, we examined whether ...
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