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Results 201 - 250 of 960
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Sukisaki Toshitaka - - 2008
The aim of this study was to examine the prolonged effect of procaterol, a short-acting bronchodilator, on lung function and exercise performance in patients with moderate to severe COPD. A randomized crossover trial was conducted. We recruited 19 patients with COPD aged 71.6+/-5.5 years. Patients were randomly assigned to receive ...
Lizak Maria Karolina - - 2008
INTRODUCTION: Pulmonary rehabilitation (PR) is an established component of COPD management. The lack of exercise performance improvement (EPI) in severely dyspnoeic patients (Medical Research Council [MRC] score 5) has been questioned. The data on the gender impact on EPI after PR remain scarce. OBJECTIVES: The impact of dyspnea severity on ...
Franssen F M E - - 2008
Impaired beta-adrenoceptor-mediated lipolysis has been reported in sarcopenic [corrected] chronic obstructive pulmonary disease (COPD) patients. This could play a role in the shift in body composition towards decreased fat-free mass (FFM) and relative maintenance of fat mass (FM). Lipolysis could be affected by chronic treatment with beta(2)-agonists or disease-related factors. ...
Cote C G - - 2008
Peak oxygen uptake (V'(O(2))) remains the gold standard measurement of exercise capacity and has been associated with survival. A modified BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index replacing the 6-min walk distance (6MWD) with V'(O(2)) as % predicted (mBODE%) has been developed and found to have excellent ...
Vassaux C - - 2008
A decreased inspiratory capacity (IC)/total lung capacity (TLC) ratio is associated with dynamic hyperinflation and decreased exercise capacity. The present authors hypothesised that static (low IC/TLC) and dynamic hyperinflation impair cardiac function as assessed by oxygen pulse at rest and during cardiopulmonary exercise testing (CPET). Lung function, body mass index, ...
Terzano Claudio - - 2009
BACKGROUND: The scientific literature does not supply enough information about the effects of postural changes on diffusing lung capacity for carbon monoxide (DL(CO)) in patients with chronic obstructive pulmonary disease (COPD), in particular regarding the prone position. OBJECTIVES: We evaluated posture-related changes in DL(CO) in healthy subjects and in COPD ...
Ozalevli Sevgi - - 2008
OBJECTIVE: To compare the health-related quality of life (HRQoL) assessed by Short Form-36 Health Survey (SF-36) and Nottingham Health Profile (NHP) on the basis of lung function and exercise capacity parameters in patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS AND MATERIALS: The investigation was a prospective, ...
Haave Einar - - 2008
PURPOSE: It is unclear whether gender impacts the effects of pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary disease (COPD). METHODS: A sample of 46 male and 46 female patients with moderate COPD, all referred to a 4-week inpatient PR program, was evaluated for perceived health status (HS), perceived ...
King Daniel A - - 2008
It is clear that being underweight is a poor prognostic sign in chronic obstructive pulmonary disease (COPD). It is also clear that undernutrition is at least in part associated with the severity of airflow obstruction. While both weight and body mass index are useful screening tools in the initial nutritional ...
Deschênes Dominic - - 2008
PURPOSE: To evaluate the concordance between subjective and objective indices of muscle fatigue during exercise and to assess the significance of the perception of dyspnea and leg fatigue for the exercise response to bronchodilation in chronic obstructive pulmonary disease (COPD). METHODS: Sixty-eight patients with COPD performed either 2 constant work-rate ...
Deacon Sarah J - - 2008
RATIONALE: Skeletal muscle strength and bulk are reduced in patients with chronic obstructive pulmonary disease (COPD) and influence quality of life, survival, and utilization of health care resources. Exercise training during pulmonary rehabilitation (PR) can reverse some of these effects. In athletes and healthy elderly individuals, dietary creatine supplementation (CrS) ...
Tanaka Yosuke - - 2008
BACKGROUND AND OBJECTIVE: Systemic effects of COPD include skeletal muscle dysfunction; the lactate threshold (LT) is an index of such dysfunction. However, it is not feasible in daily clinical practice to accurately determine the LT in all patients with COPD. There is no simple, practical and non-invasive index for determining ...
von Leupoldt Andreas - - 2008
The effects of intensive 3-week outpatient pulmonary rehabilitation (PR) on exercise capacity, dyspnea, and health-related quality of life (HRQL) were investigated in patients with COPD. Two hundred ten patients with COPD (mean FEV(1) = 54%pred) underwent PR consisting of exercise training, patient and psychosocial education, breathing and relaxation therapy, nutrition ...
Pitta Fábio - - 2008
BACKGROUND: Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program. METHODS: Physical activities in daily life (activity monitoring), pulmonary function (spirometry), exercise capacity (incremental cycle-ergometer testing and 6-min walk distance testing), ...
Manwaring Kim - - 2008
Introduction The great majority of shunt failures are due to proximal obstruction. Percutaneous reopening of the obstructed catheter by radiofrequency or ultrasound techniques has been suggested as a minimally invasive approach of maintenance rather than replacement. The obvious benefit is a decreased risk of removal and repositioning into an often ...
Banzett Robert B - - 2008
It is hypothesized that the affective dimension of dyspnea (unpleasantness, emotional response) is not strictly dependent on the intensity of dyspnea. We tested the hypothesis that the ratio of immediate unpleasantness (A(1)) to sensory intensity (SI) varies depending on the type of dyspnea. Twelve healthy subjects experienced three stimuli: stimulus ...
Eisner Mark D - - 2008
The authors' objective was to analyze the impact of respiratory impairment on the risk of physical functional limitations among adults with chronic obstructive pulmonary disease (COPD). They hypothesized that greater pulmonary function decrement would result in a broad array of physical functional limitations involving organ systems remote from the lung, ...
Aliverti Andrea A - - 2008
n/a Key words: exercise, COPD, muscle, dynamic hyperinflation, energy.
Vogiatzis I - - 2008
The present study investigated how end-expiratory ribcage and abdominal volume regulation during exercise is related to the degree of dynamic chest wall hyperinflation in patients with different spirometric severity of chronic obstructive pulmonary disease (COPD) based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. In total, 42 ...
Saracino Amanda - - 2008
BACKGROUND: Acute shortness of breath (SOB) is a common symptom and a potentially significant marker of cardiorespiratory disease. The subjective and unmeasurable nature of breathlessness can make its clinical evaluation difficult. This study aimed to investigate the convergent validity of a verbal 0-10 rating scale for SOB. METHODS: This prospective ...
Vivodtzev Isabelle - - 2008
Exercise training comprises a variety of modalities in patients with chronic obstructive pulmonary disease (COPD). In the last 10 years, neuromuscular electrical stimulation (NMES) has attracted the interests of clinicians as a novel rehabilitative approach. Because of a limited impact on ventilatory requirements and dyspnea, NMES appears as a promising ...
O'Brien Kelly - - 2008
PURPOSE: To determine the effect of inspiratory muscle training (IMT) (alone or combined with exercise and/or pulmonary rehabilitation) and compare with other rehabilitation interventions among adults with chronic obstructive pulmonary disease (COPD). METHODS: We conducted a systematic review, using Cochrane Collaboration protocol. We included randomized controlled trials, published in English, ...
Chang Angela T - - 2008
PURPOSE: To investigate balance following a submaximal exercise task (6-minute walk test [6MWT]) in patients with chronic obstructive pulmonary disease (COPD). METHODS: A consecutive sample of 19 patients with COPD from an institutional pulmonary rehabilitation program served as participants. The following measures were recorded before and following a 6MWT: (1) ...
Sillen Maurice J H - - 2008
Resistance training and transcutaneous neuromuscular electrical stimulation (NMES) are new modalities in rehabilitation of severely disabled patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to compare the metabolic response during resistance training and during NMES of the quadriceps femoris muscles in patients with COPD entering ...
Borel Jean-Christian - - 2008
BACKGROUND: Exercise intolerance limits chronic restrictive respiratory failure (CRF) patients from participating in daily activities. The specific modalities that could improve exercise tolerance in these patients remain to be established. OBJECTIVE: To investigate exercise endurance and associated physiological responses with non-invasive ventilation (NIV) during exercise in restrictive CRF patients. METHODS: ...
Kushibe Keiji - - 2008
The aim of this study is to clarify whether patients with chronic obstructive pulmonary disease (COPD) lose less exercise capacity after lobectomy than do those without COPD, to the same extent as ventilatory capacity and lobectomy for selected patients with severe emphysema improve exercise capacity like ventilatory capacity. Seventy non-COPD ...
Calvert Lori D - - 2008
RATIONALE: Impaired skeletal muscle function contributes to exercise limitation in patients with chronic obstructive pulmonary disease (COPD). This is characterized by reduced mitochondrial adenosine triphosphate generation, and greater reliance on nonmitochondrial energy production. Dichloroacetate (DCA) infusion activates muscle pyruvate dehydrogenase complex (PDC) at rest, reducing inertia in mitochondrial energy delivery ...
Jensen D - - 2008
BACKGROUND: This study examined the effects of inhaled furosemide on the ventilatory and perceptual response to high-intensity constant-load cycle exercise in chronic obstructive pulmonary disease (COPD). METHODS: In a randomised, double-blind, placebo-controlled, crossover study, 20 patients with COPD (mean (SD) forced expiratory volume in 1 s 45 (15)% predicted) received ...
Hopkinson Nicholas S - - 2008
BACKGROUND: Quadriceps weakness is an important complication of chronic obstructive pulmonary disease (COPD) and is associated with impaired exercise capacity and greater mortality. Its etiology is multifactorial, and evidence is growing that it is partly determined by genetic susceptibility. OBJECTIVE: Using an established cohort, we tested whether quadriceps weakness in ...
Gosman Margot M E - - 2008
BACKGROUND: In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in COPD and ...
Corda Luciano - - 2008
BACKGROUND: No consistent data are available regarding the effect of inhaled corticosteroids (ICS) in alpha(1)-antitrypsin-deficiency (AATD)-related COPD. Recent data report inflammatory effects of the polymers of alpha(1)-antitrypsin on the peripheral lung. OBJECTIVES: The aim of this study was to assess the effectiveness of an extra-fine ICS, hydrofluoroalkane-134a beclometasone dipropionate (HFA-BDP) ...
Medinas-Amorós M - - 2008
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is currently the fourth cause of mortality and morbility in the developed world. Patients with COPD experience a progressive deterioration of health-related quality of life (HRQOL). A new model of severity classification, the body mass index, bronchial obstruction, dyspnoea, exercise (BODE) index, has recently ...
Nguyen Huong Q - - 2008
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) continue to experience dyspnea with activities of daily living (ADL) despite optimal medical management. Information and communication technologies may facilitate collaborative symptom management and could potentially increase the reach of such interventions to those who are unable to attend face-to-face pulmonary rehabilitation ...
Burkow Tatjana M - - 2008
This paper describes an easy to use home-based eHealth system for chronic disease management. We present the design and implementation of a prototype for home based education, exercises, treatment and following-up, with the TV and a remote control as user interface. We also briefly describe field trials of the system ...
Tiep B - - 2008
Collective experience with pulmonary rehabilitation and disease management has shown that patients with lung diseases including COPD and restrictive lung diseases live a longer and more productive quality of life if they can remain active. Patients who require oxygen supplementation but can otherwise be active should have the most portable ...
Holverda Sebastiaan - - 2008
BACKGROUND: We investigated in chronic obstructive pulmonary disease (COPD) patients whether a single dose of sildenafil can attenuate the exercise-induced increase in pulmonary artery pressure, thereby allowing augmentation of stroke volume (SV), and improving maximal exercise capacity. METHODS: Eighteen COPD patients (GOLD II-IV) underwent right heart catheterization at rest and ...
Delample Delphine - - 2008
This study investigated the effects of a prior individualized training program (TP) on the response to acute oxygen supply during exercise in chronic obstructive pulmonary disease (COPD) patients showing exercise-induced desaturation. Twenty-two COPD patients (mean [SD] FEV1 = 52.1 [3]% predicted) who desaturated on exercise participated in a TP. Exercise ...
Shahin Barakat - - 2008
Abstract: Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). Given that most of these patients have respiratory and peripheral muscle weakness, dyspnea and functional exercise capacity may improve as a result of inspiratory muscle training (IMT). The present study is designed to investigate ...
van Wetering Carel R - - 2008
In contrast with the frequency distribution of chronic obstructive pulmonary disease (COPD) stages in the population, in which the majority of the patients is classified as GOLD 2, much less information is available on the prevalence and implications of systemic manifestations in less severe patients relative to GOLD 3 and ...
Güell Rous Rosa - - 2008
Long-term oxygen therapy (LTOT) is the treatment proven to improve survival in chronic obstructive pulmonary disease (COPD) patients with chronic respiratory failure. It also appears to reduce the number of hospitalizations, increase effort capacity, and improve health-related quality of life. Standard LTOT criteria are related to COPD patients who have ...
Steiropoulos Paschalis - - 2008
Bronchodilators represent the hallmark of symptomatic treatment of Chronic Obstructive Pulmonary Disease (COPD). There are four categories of bronchodilators: anticholinergics, methylxanthines, short-acting beta2-agonists, and long-acting beta2-agonists such as formoterol. Significant research has been performed to investigate the efficacy, safety and tolerability of formoterol in the therapeutic field of COPD. Formoterol ...
Lee Tsung-Ming - - 2008
Inflammation is increased in chronic obstructive pulmonary disease (COPD) and plays a role in exercise intolerance. We investigated whether pravastatin administration is effective in improving exercise capacity in patients with COPD, and whether baseline or serial changes in high-sensitivity C-reactive protein (hs-CRP) over time are associated with corresponding changes in ...
Calvert L D - - 2008
The plasma ammonia response to exercise in chronic obstructive pulmonary disease (COPD) was examined and the relationship between plasma ammonia concentration and muscle adenine nucleotide metabolism was explored. In total, 25 stable COPD patients and 13 similar-aged controls underwent incremental and constant-work rate cycle exercise tests. Arterialised venous blood was ...
Rietema H - - 2008
In chronic obstructive pulmonary disease (COPD) patients, stroke volume response to exercise is impaired. The aim of the present study was to investigate whether 3 months of sildenafil treatment improves stroke volume and, if so, whether this improvement is related to the pulmonary artery pressure and translated into an improved ...
McKeough Zoe J - - 2008
The aim of the study was to compare the metabolic, ventilatory and dyspnoea responses of a single bout of high intensity, constant-load arm exercise to peak arm exercise in people with chronic obstructive pulmonary disease (COPD). Thirty people with COPD (mean age+/-SD=65+/-8 years; FEV1% predicted=56+/-12%) were included. All subjects performed ...
Brouillard C - - 2008
Few studies have shown that the endurance shuttle walking test (ESWT) is responsive to treatment in patients with chronic obstructive pulmonary disease (COPD). This exercise test needs to be further investigated because of its relevance for activity of daily living. The aim of the present study was to evaluate, in ...
Fernandes M - - 2007
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) present abnormal respiratory mechanics, but its relation to ventilation variables at rest is not fully understood. METHODS: We evaluated breathing pattern, thoracoabdominal motion, and ventilation in moderate and severe COPD patients by means of respiratory inductive plethysmograph and analysis of respiratory metabolism ...
Laveneziana Pierantonio - - 2007
Dyspnea (respiratory difficulty) and activity limitation are the primary symptoms of chronic obstructive pulmonary disease (COPD) and progress relentlessly as the disease advances, contributing to reduced quality of life. In COPD, the mechanisms of dyspnea are multifactorial, but abnormal dynamic ventilatory mechanics are believed to play a central role. In ...
Ofir Dror - - 2008
RATIONALE: Smokers with a relatively preserved FEV(1) may experience dyspnea and activity limitation but little is known about underlying mechanisms. OBJECTIVES: To examine ventilatory constraints during exercise in symptomatic smokers with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage I chronic obstructive lung disease (COPD) so as to uncover ...
Puhan M A - - 2008
Chronic obstructive pulmonary disease (COPD) patients with limited ability to follow exercise protocols may receive smaller benefits from rehabilitation. The association between the ability to follow exercise protocols and short-term outcomes of rehabilitation was assessed in COPD patients. As a measure of the ability to follow exercise protocols, the number ...
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