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Arena Ross R 1Department of Physical Therapy and Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL 2Heart Failure Unit, Cardiology, University of Milano, IRCCS Policlinico San Donato, Milano, Italy 3Department of Physical Therapy, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 4Division of Cardiology, VA Palo Alto Healthcare System, Palo Alto, - - 2014
AHA/ACC class recommendations and associated level of evidence for cardiopulmonary exercise testing (CPX) have been put forth. A new paradigm is proposed for CPX use and interpretation in heart failure (HF). Evidence for this new paradigm will be provided showing that clinical utilization, class recommendations and associated level of evidence ...
Nakanishi Michio M Department of Cardiovascular Medicine, National Cerebral and Cardiovascular - - 2014
Background:Peak oxygen uptake (V̇O2) and ventilatory efficiency (V̇E/V̇CO2slope) measured on cardiopulmonary exercise testing (CPX) are prognostic indicators in heart failure (HF) patients, but peak V̇O2is influenced by patient effort. In CPX targeting a peak respiratory exchange ratio (pRER; an objective index of effort adequacy) higher than the commonly recommended level, ...
Arena Ross R aDepartment of Physical Therapy and Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois Chicago, Chicago, Illinois bDepartment of Physical Therapy, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA cCardiopulmonary Physiotherapy Laboratory, Federal University of São Carlos, São Paulo, - - 2014
Functional capacity is a broad term that describes a person's ability to perform the daily activities that require physical exertion. Patients diagnosed with heart failure, regardless of cause, demonstrate a compromised functional capacity. The ability to perform aerobic activities is a central, but not complete, determinant of functional capacity. Muscular ...
Nakae Ichiro I Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan, - - 2014
To investigate clinical usefulness of a novel program "Heart Function View (HFV)" for evaluating left ventricular (LV) function from myocardial perfusion SPECT (MPS), we compared LV functional parameters (F(x)) calculated by HFV with those obtained by the other similar programs QGS and cardioGRAF or by ultrasound echocardiography (UCG) and examined ...
Petkow Dimitrow Pawel - - 2014
(Semi) supine exercise testing has an established role in the evaluation of patients with valvular heart disease and can help clinical decision making. Stress echocardiography has the advantages of its wide availability, low cost, and versatility for the assessment of disease severity. However, exercise-induced changes in valve hemodynamics, left ventricular ...
Reed Jennifer L JL Prevention and Rehabilitation Centre, University of Ottawa Heart Institute, Ottawa, Ontario, - - 2014
This review focuses on recent literature examining the validity and reliability of the talk test for prescribing and monitoring exercise intensity. The utility of the talk test for high-intensity interval training and recently proposed exercise training guidelines for patients with atrial fibrillation is also examined. In healthy adults and patients ...
Riehle Christian C Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, - - 2014
Insulin and IGF-1 receptor signaling pathways differentially modulate cardiac growth under resting conditions and following exercise training. These effects are mediated by insulin receptor substrates (IRS) 1 and 2, which also differentially regulate resting cardiac mass. To determine the role of IRS isoforms in mediating the hypertrophic and metabolic adaptations ...
Capoulade Romain R Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart & Lung Institute, Laval University, Québec city, Québec, - - 2014
Exercise-stress echocardiography is useful in management and risk stratification of patients with asymptomatic aortic stenosis (AS). Resting B-type natriuretic peptide (BNP) level is associated with increased risk of adverse events. The incremental prognostic value of BNP response during exercise is unknown. The purpose of this study was to assess the ...
Lemery Robert R Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, - - 2014
Weight, height, blood pressure, diabetes, sleep apnea, alcohol, stimulants and exercise: these clinical characteristics or risk factors (1) have been implicated or associated with atrial fibrillation (AF). C-reactive protein, interlukin 6, endothelin-1, SCN5A, chromosome 4q25 and the PITX2 gene: these biological, biochemical and cellular abnormalities have all been associated with ...
Ratanasit Nithima - - 2014
Left atrial volume (LAV) and exercise capacity are important prognostic determinants of cardiovascular risk. Exercise intolerance and increased LAV are expected in patients with diastolic dysfunction. While dyspnea is the symptom reported by the patient and considered subjective, exercise capacity obtained by exercise testing provides an objective measure of cardiovascular ...
Isacco Laurie L a Laboratory Culture Sport Health Society, and Exercise Performance, Health, Innovation Platform, Franche-Comte University, F-25000 Besançon, - - 2014
Because of their hormonal content, oral contraceptives may alter lipolytic activity under resting or exercise conditions in women. The aim of the present study was to compare lipid mobilization in a postprandial state at rest and during exercise in oral contraceptive users (OC+) versus nonusers (OC-). The metabolic (glucose, glycerol, ...
Piotrowicz Ewa E Telecardiology Center, Institute of Cardiology, Alpejska 42, 04-628, Warszawa, Poland, - - 2014
The article discusses the problem of motivating and encouraging patients with heart failure to perform regular exercise training. Firstly, the benefits of exercise training are presented, and rational and convincing arguments justifying its implementation in heart failure patients are provided. Secondly, the issue of overcoming barriers to exercise training implementation ...
Keteyian Steven J SJ Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michigan (Dr Keteyian); Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota (Drs Squires and Thomas); and University of Vermont College of Medicine, Burlington, Vermont (Dr - - 2014
A recent policy change from the Centers for Medicare and Medicaid Services includes coverage of cardiac rehabilitation (CR) for patients with chronic heart failure (CHF) with reduced ejection fraction. This article provides a framework by which CR programs can incorporate disease-specific services for patients with CHF who participate in CR. ...
Huang Shu-Chun SC Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkuo, - - 2014
Although high-intensity interval aerobic training (HIT) effectively improves aerobic fitness, the risk of cardiac arrest transiently increases during strenuous physical exertion in patients with cardiovascular disease. For safety and efficacy concerns, this investigation explored the effect of a modified HIT (mHIT) on exertional ventilatory-hemodynamic efficiency in heart failure patients with ...
Sheikh Nabeel N St. George's University of - - 2014
Pre-participation cardiovascular evaluation is being recommended by a growing number of sporting bodies and scientific organisations in an attempt to identify athletes harbouring quiescent cardiac conditions which put them at risk of exercise-related sudden cardiac death (SCD). However cardiac adaptation to exercise may itself result in ECG patterns that overlap ...
Jamil Haqeel H University of Leeds and Leeds General - - 2014
Increased cardiac output during exercise is the result of greater stroke volume and an increase in heart rate. It is therefore assumed that a limitation to heart rate rise (HRR) in response to activity, chronotropic incompetence (CI), could contribute to the exercise intolerance that is characteristic of chronic heart failure ...
Reis Hugo V HV Department of Physical Therapy, Faculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
Background: Chronic heart failure (CHF) leads to exercise intolerance. However, non-invasive ventilation is able to improve functional capacity of patients with CHF. Objectives: The aim of this study was to evaluate the effectiveness of continuous positive airway pressure (CPAP) on physical exercise tolerance and heart rate variability (HRV) in patients ...
Park Won Hah WH Divison of Sports Medicine, Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
A left ventricular assist device (LVAD) is a mechanical circulation support implanted for patients with end-stage heart failure. It may be used either as a bridge to cardiac transplantation or as a destination therapy. The health of a 75-year-old man with a medical history of systolic heart failure worsened. Therefore, ...
Borgdorff Marinus Alexander J MA Center for Congenital Heart Diseases, Beatrix Childrens Hospital, University of Groningen, University Medical Center Groningen - - 2014
Aims: Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive Sildenafil treatment has been shown to enhance systolic RV function and improve exercise capacity in a model of fixed RV pressure load. However, it is unknown whether Sildenafil has ...
Liu Wei-Hua WH State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, - - 2014
Exercise impairment is common in chronic left heart failure and pulmonary arterial hypertension (PAH). Exercise impairment degree is a strong predictor of clinical outcome. Our purpose was to evaluate differences in exercise capacity using cardiopulmonary exercise testing (CPX) in patients with chronic left and right heart failure, and determine which ...
Henri Christine C Departments of Cardiology and Radiology, University of Liège, Groupe Interdisciplinaire de Génoprotéomique Appliquée Cardiovascular Sciences, Heart Valve Clinic, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium; Department of Medicine, University of Montreal, Montreal Heart Institute, Montreal, - - 2014
B-type natriuretic peptide (BNP) level may be a useful prognostic marker for the management of asymptomatic patients with aortic stenosis (AS). The aim of this study was to identify the echocardiographic determinants of BNP changes during follow-up in AS. We studied 61 asymptomatic patients with greater than moderate AS and ...
Camboni Daniele - - 2014
LVAD speed adjustment according to a functioning aortic valve has hypothetic advantages but could lead to submaximal support. The consequences of an open aortic valve policy on exercise capacity and hemodynamics have not yet been investigated systematically. Ambulatory patients under LVAD support (INCOR(R), Berlin Heart, mean support time 465 +/- ...
Mohammed Selma F SF Division of Cardiovascular Diseases, Mayo Graduate School, Mayo Clinic, Rochester, MN - - 2014
-Exercise intolerance is a hallmark of heart failure (HF), but factors associated with impaired exercise capacity in HF with preserved EF (HFpEF) are unclear. We hypothesized that in HFpEF, the severity of resting ventricular and vascular dysfunction are associated with impairment in exercise tolerance as assessed by peak oxygen consumption ...
Khan Abigail May AM Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, - - 2014
Adults with congenital heart disease (CHD) are at high risk for morbidity and mortality. Identifying those who are at highest risk of complications can be challenging, in part because self-reported functional status is not a reliable indicator of physiological status. Individuals with CHD may present with exercise limitation due to ...
Sacre Julian W JW School of Human Movement Studies, University of Queensland, Brisbane, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: - - 2014
Autonomic dysfunction may contribute to the etiology and exercise intolerance of subclinical diabetic heart disease. This study sought the efficacy of exercise training for improvement of peak oxygen uptake (VO2peak) and cardiac autonomic function in type 2 diabetic patients with non-ischemic subclinical left-ventricular (LV) dysfunction. Forty-nine type 2 diabetic patients ...
Momeni Ali - - 2014
Introduction. Cardiovascular disease is the major cause of death in hemodialysis patients. Regular aerobic or intradialytic exercise may play a role in reducing cardiovascular mortality in these patients. The aim of this study was to evaluate the relationship between intradialytic exercise and echocardiographic findings. Methods and Materials. Forty patients were ...
Peteiro Jesús J Laboratorio de Ecocardiografia de Estrés, Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, España. Electronic address: - - 2014
Left ventricular torsion decreases during transmural myocardial ischemia, but the effect of exercise on left ventricular torsion has not been widely studied. We hypothesized that exercise-induced ischemia may impair left ventricular torsion. Therefore, our aim was to study the effects of exercise on left ventricular torsion in patients with an ...
Stevens Michael C MC Innovative Cardiovascular Engineering and Technology Laboratory, The Prince Charles Hospital, Brisbane, Queensland, Australia; Critical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Queensland, Australia; School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, - - 2014
Dual rotary left ventricular assist devices (LVADs) can provide biventricular mechanical support during heart failure. Coordination of left and right pump speeds is critical not only to avoid ventricular suction and to match cardiac output with demand, but also to ensure balanced systemic and pulmonary circulatory volumes. Physiological control systems ...
Eindhoven Jannet A JA Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The - - 2014
Amino-terminal B-type natriuretic peptide (NT-proBNP) may detect early cardiac dysfunction in adults with tetralogy of Fallot (ToF) late after corrective surgery. We aimed to determine the value of NT-proBNP in adults with ToF and establish its relationship with echocardiography and exercise capacity. NT-proBNP measurement, electrocardiography and detailed 2D-echocardiography were performed ...
van Empel Vanessa P M VP Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia; Department of Cardiology, Maastricht University Medical Centre, Maastricht, The - - 2014
This study aimed to define the influence of healthy aging on the central hemodynamic response to exercise. Advancing age results in numerous alterations to the cardiovascular system and is a major risk factor to develop heart failure. In patients with suspected heart failure with preserved ejection fraction, there is an ...
Oliveira Rudolf K F RK Dept of Medicine, Federal University of São Paulo (UNIFESP), - - 2014
Chronic hypersensitivity pneumonitis is a common fibrotic interstitial lung disease. The prevalence of pulmonary hypertension diagnosed by right heart catheterisation and its cardiopulmonary function findings in patients with chronic hypersensitivity pneumonitis are unknown.Consecutive symptomatic patients with chronic hypersensitivity pneumonitis were prospectively evaluated. All patients were submitted to right heart catheterisation, ...
Sahin Özdemirel Tuğce T Clinic of Chest Diseases, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital; Ankara-Turkey. - - 2014
During the course of chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PH) and right ventricular (RV) failure may develop due to elevated afterload of the RV. In those patients, exercise capacity is reduced due to pulmonary and cardiac limitations. We investigated relationships between serum N-terminal of proB-type natriuretic peptide (NT-proBNP) ...
Sato Takamasa T Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, - - 2014
The purpose in the present study was to compare prognostic risk factors between older and younger chronic heart failure (CHF) patients. We examined 598 consecutive CHF patients (476 men and 122 women, mean age 61.4 ± 14.3 years) who underwent cardiopulmonary exercise testing, echocardiography and blood examination. We divided the 598 patients ...
Grazioli Gonzalo G Grup de Treball Cardiologia Esportiva, Institut del Tòrax, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, - - 2014
Despite the established diagnostic value of the electrocardiogram in preparticipation screening of athletes, some cardiac structural changes can be missed, particularly in early disease stages. The aim of this study was to evaluate the prevalence of cardiac structural changes via the systematic use of echocardiography in preparticipation screening of competitive ...
Whinnett Zachary I - - 2014
Echocardiographic optimization of pacemaker settings is the current standard of care for patients treated with cardiac resynchronization therapy. However, the process requires considerable time of expert staff. The BRAVO study is a non-inferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular (VV) delay with an alternative method using non-invasive ...
Marchandise Sébastien S Pôle de recherche cardiovasculaire, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: - - 2014
The early diastolic transmitral velocity/tissue Doppler imaging mitral annular early diastolic velocity (E/e') ratio is used to estimate left ventricular (LV) filling pressures at rest. However, there are only limited data that validate its use during exercise. Accordingly, the aim of this study was to test the ability of E/e' ...
Balbaloglu Ozlem O Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bozok University, Yozgat, - - 2014
Our aim was to evaluate electrocardiographic and echocardiographic properties and exercise response of patients with fibromyalgia (FM). The study included 60 women with primary FM and 30 healthy individuals. Resting electrocardiography, echocardiography and exercise treadmill test were used to compare these two groups. At apical four-chamber window, samples of transmitral ...
Almeida Ana Rita AR Serviço de Cardiologia do Hospital Garcia de Orta, Almada, Portugal. Electronic address: - - 2014
Right ventricular function is a major determinant of prognosis in pulmonary hypertension. The aim of this study was to assess and compare right ventricular contractile reserve in healthy subjects (controls) and in subjects with pulmonary hypertension (cases). In this prospective study of seven cases and seven controls undergoing treadmill stress ...
Baydar Onur O Department of Cardiology, Institute of Cardiology, Istanbul University, Istanbul, - - 2014
Right ventricular (RV) deformational mechanics have been demonstrated in patients with atrial septal defect (ASD) at rest, but there is lack of information on their adaptation to exercise. The aim of this study was to assess the adaptability of RV strains and strain rates (SRs) during exercise in patients with ...
Hager Alfred A Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany, - - 2014
A single dose of sildenafil improves exercise capacity in Fontan patients. However, a recent study failed to show a long-term effect of sildenafil. This study evaluated whether there are factors that might predict sildenafil effects. We studied 36 patients (16-42 years, 14 female) with univentricular heart after various modifications of the ...
De Schryver Nicolas N Division of Cardiology Unit of rhythmology, Cliniques Universitaires St-Luc, Université catholique de Louvain, 1200 Brussels, - - 2014
Atrial fibrillation (AF) patients treated according to a rate-control strategy seem to have excellent outcomes as long as their ventricular response is kept low. However, the stringency of the rate control to adopt with pharmacologic agents is not clearly defined. In particular, the clinical importance of preserving a heart rate ...
Methawasin Mei M University of Arizona, Tucson, - - 2014
Experimentally upregulating compliant titins has been suggested as a therapeutic for lowering pathological diastolic stiffness levels. However, how increasing titin compliance impacts global cardiac function requires in-depth study. We investigate the effect of upregulating compliant titins in a novel mouse model with a genetically altered titin splicing factor; integrative approaches ...
Argulian Edgar E Division of Cardiology, Mount Sinai St Luke's Hospital, Mt Sinai Health System, New York, New York. Electronic address: - - 2014
Ventricular-arterial stiffening is a part of the aging process that is amplified by various comorbidities. It affects normal cardiovascular reserve and limits exercise capacity. The aim of this study was to explore the association of physiologic determinants of ventricular-arterial interaction with exercise capacity in patients referred for exercise echocardiography with ...
Cassar Andrew A Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
To assess the safety and efficacy of extracorporeal shockwave myocardial revascularization (ESMR) therapy in treating patients with refractory angina pectoris. A single-arm multicenter prospective trial to assess safety and efficacy of the ESMR therapy in patients with refractory angina (class III/IV angina) was performed. Screening exercise treadmill tests and pharmacological ...
Lindemberg Sabrina S Programa de Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, - - 2014
Background: Heart rate recovery at one minute of rest (HRR1) is a predictor of mortality in heart failure (HF), but its prognosis has not been assessed at six-minute walk test (6MWT) in these patients. Objective: This study aimed to determine the HRR1 at 6MWT in patients with HF and its ...
Taskin Halil - - 2014
The purpose of this study was to examine the heart rate recovery depending on anaerobic running. A total of 23 professional soccer players who were player of Turkish Super Leagues, were examined. Anaerobic Run test was applied to the soccer players and their heart rates were recorded before running, just ...
Henri Christine C Department of Cardiology and Heart Valve Clinic, GIGA Cardiovascular Sciences, University of Liège, CHU Sart Tilman, Liège, - - 2014
The management of asymptomatic patients with severe aortic stenosis (AS) remains controversial. Recent series reported that early aortic valve replacement might be associated with improved clinical outcomes. However, the risk-benefit ratio should be carefully evaluated and early surgery only be proposed to a subset of asymptomatic patients considered at higher ...
Voilliot Damien D University of Liège Hospital, GIGA Cardiovascular Sciences, Department of Cardiology, Heart Valve Clinic, University Hospital Sart Tilman, Liège, - - 2014
Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. We prospectively enrolled 63 patients with SSc (age 54±3years, 76% female) followed in CHU Sart-Tilman ...
Cesari F F Francesca Cesari, Department of Clinical and Experimental Medicine,, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50127 Florence, Italy, Tel.: +39 055 7949420, Fax: +39 055 7949418 , E-mail: - - 2014
An increase of endothelial progenitor cells (EPCs) among acute myocardial infarction (AMI) patients participating in a cardiac rehabilitation (CR) program has been reported, but no data on the impact of adherence to lifestyle recommendations provided during a CR program on EPCs are available. It was our aim to investigate the ...
Duncker Dirk J DJ Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000, CA, Rotterdam, The Netherlands, - - 2014
Cardiac remodeling in response to a myocardial infarction or chronic pressure-overload is an independent risk factor for the development of heart failure. In contrast, cardiac remodeling produced by regular physical exercise is associated with a decreased risk for heart failure. There is evidence that exercise training has a beneficial effect ...
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