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Sato Takamasa T Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, - - 2014
The purpose in the present study was to compare prognostic risk factors between older and younger chronic heart failure (CHF) patients. We examined 598 consecutive CHF patients (476 men and 122 women, mean age 61.4 ± 14.3 years) who underwent cardiopulmonary exercise testing, echocardiography and blood examination. We divided the 598 patients ...
Grazioli Gonzalo G Grup de Treball Cardiologia Esportiva, Institut del Tòrax, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, - - 2014
Despite the established diagnostic value of the electrocardiogram in preparticipation screening of athletes, some cardiac structural changes can be missed, particularly in early disease stages. The aim of this study was to evaluate the prevalence of cardiac structural changes via the systematic use of echocardiography in preparticipation screening of competitive ...
Whinnett Zachary I - - 2014
Echocardiographic optimization of pacemaker settings is the current standard of care for patients treated with cardiac resynchronization therapy. However, the process requires considerable time of expert staff. The BRAVO study is a non-inferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular (VV) delay with an alternative method using non-invasive ...
Le Goff C C University Hospital of Liège, Liège, - - 2014
Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Prospective, cohort study. Amateur marathon runners and ultrarunners. ...
Balbaloglu Ozlem O Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bozok University, Yozgat, - - 2014
Our aim was to evaluate electrocardiographic and echocardiographic properties and exercise response of patients with fibromyalgia (FM). The study included 60 women with primary FM and 30 healthy individuals. Resting electrocardiography, echocardiography and exercise treadmill test were used to compare these two groups. At apical four-chamber window, samples of transmitral ...
Almeida Ana Rita AR Serviço de Cardiologia do Hospital Garcia de Orta, Almada, Portugal. Electronic address: - - 2014
Right ventricular function is a major determinant of prognosis in pulmonary hypertension. The aim of this study was to assess and compare right ventricular contractile reserve in healthy subjects (controls) and in subjects with pulmonary hypertension (cases). In this prospective study of seven cases and seven controls undergoing treadmill stress ...
Baydar Onur O Department of Cardiology, Institute of Cardiology, Istanbul University, Istanbul, - - 2014
Right ventricular (RV) deformational mechanics have been demonstrated in patients with atrial septal defect (ASD) at rest, but there is lack of information on their adaptation to exercise. The aim of this study was to assess the adaptability of RV strains and strain rates (SRs) during exercise in patients with ...
Hager Alfred A Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany, - - 2014
A single dose of sildenafil improves exercise capacity in Fontan patients. However, a recent study failed to show a long-term effect of sildenafil. This study evaluated whether there are factors that might predict sildenafil effects. We studied 36 patients (16-42 years, 14 female) with univentricular heart after various modifications of the ...
De Schryver Nicolas N Division of Cardiology Unit of rhythmology, Cliniques Universitaires St-Luc, Université catholique de Louvain, 1200 Brussels, - - 2014
Atrial fibrillation (AF) patients treated according to a rate-control strategy seem to have excellent outcomes as long as their ventricular response is kept low. However, the stringency of the rate control to adopt with pharmacologic agents is not clearly defined. In particular, the clinical importance of preserving a heart rate ...
Methawasin Mei M University of Arizona, Tucson, - - 2014
Experimentally upregulating compliant titins has been suggested as a therapeutic for lowering pathological diastolic stiffness levels. However, how increasing titin compliance impacts global cardiac function requires in-depth study. We investigate the effect of upregulating compliant titins in a novel mouse model with a genetically altered titin splicing factor; integrative approaches ...
Argulian Edgar E Division of Cardiology, Mount Sinai St Luke's Hospital, Mt Sinai Health System, New York, New York. Electronic address: - - 2014
Ventricular-arterial stiffening is a part of the aging process that is amplified by various comorbidities. It affects normal cardiovascular reserve and limits exercise capacity. The aim of this study was to explore the association of physiologic determinants of ventricular-arterial interaction with exercise capacity in patients referred for exercise echocardiography with ...
Cassar Andrew A Division of Cardiovascular Diseases, Mayo Clinic, Rochester, - - 2014
To assess the safety and efficacy of extracorporeal shockwave myocardial revascularization (ESMR) therapy in treating patients with refractory angina pectoris. A single-arm multicenter prospective trial to assess safety and efficacy of the ESMR therapy in patients with refractory angina (class III/IV angina) was performed. Screening exercise treadmill tests and pharmacological ...
Lindemberg Sabrina S Programa de Pós-graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, - - 2014
Background: Heart rate recovery at one minute of rest (HRR1) is a predictor of mortality in heart failure (HF), but its prognosis has not been assessed at six-minute walk test (6MWT) in these patients. Objective: This study aimed to determine the HRR1 at 6MWT in patients with HF and its ...
Voilliot Damien D University of Liège Hospital, GIGA Cardiovascular Sciences, Department of Cardiology, Heart Valve Clinic, University Hospital Sart Tilman, Liège, - - 2014
Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. We prospectively enrolled 63 patients with SSc (age 54±3years, 76% female) followed in CHU Sart-Tilman ...
Cesari F F Francesca Cesari, Department of Clinical and Experimental Medicine,, Thrombosis Centre, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50127 Florence, Italy, Tel.: +39 055 7949420, Fax: +39 055 7949418 , E-mail: - - 2014
An increase of endothelial progenitor cells (EPCs) among acute myocardial infarction (AMI) patients participating in a cardiac rehabilitation (CR) program has been reported, but no data on the impact of adherence to lifestyle recommendations provided during a CR program on EPCs are available. It was our aim to investigate the ...
Duncker Dirk J DJ Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000, CA, Rotterdam, The Netherlands, - - 2014
Cardiac remodeling in response to a myocardial infarction or chronic pressure-overload is an independent risk factor for the development of heart failure. In contrast, cardiac remodeling produced by regular physical exercise is associated with a decreased risk for heart failure. There is evidence that exercise training has a beneficial effect ...
Zile Michael R MR Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina. Electronic address: - - 2014
The purpose of this study was to evaluate the efficacy and safety of the selective endothelin type A (ETA) receptor antagonist sitaxsentan in patients who have heart failure with preserved ejection fraction (HFpEF). Fifty percent of heart failure (HF) patients have a preserved ejection fraction. No treatment has been shown ...
Asrar Ul Haq Muhammad - - 2014
2D speckle tracking echocardiography allows for assessment of left ventricular (LV) torsional deformation as a composite function of the radial, longitudinal and circumferential fibres. We test the hypothesis that post-exercise LV torsional dynamics are more sensitive markers for myocardial dysfunction than resting measures, and better predictors for exercise capacity compared ...
Alsara Osama O Department of Internal Medicine, Michigan State University, East Lansing (Dr Alsara); Department of Internal Medicine, Division of Cardiovascular Diseases and Internal Medicine, Cardiovascular Health Clinic, Rochester, Minnesota (Drs Perez-Terzic, Squires, and Thomas); and Department of Physical Medicine and Rehabilitation (Dr Perez-Terzic), Department of Internal Medicine, Division of General Internal Medicine (Drs Dandamudi and Miranda), and Department of Surgery, Division of Cardiovascular Surgery (Dr Park), Mayo Clinic, Rochester, - - 2014
Because a limited number of patients receive heart transplantation, alternative therapies, such as left ventricular assist device (LVAD) therapy, have emerged. Published studies have shown that LVAD implantation, by itself, improves exercise tolerance to the point where it is comparable to those with mild heart failure. The improvement in exercise ...
Knackstedt Christian C Department of Cardiology, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, The Netherlands, - - 2014
There is some evidence that long-term high-intensity endurance training might be associated with deterioration in cardiac function and might impose a potential risk for cardiovascular events. Thus, the intention was to retrospectively evaluate the cardiac status in former endurance athletes, particularly right ventricular (RV) dimension and function, to reveal potential ...
Aagaard Philip P 1Karolinska Institutet, Department of Cardiology Karolinska University Hospital, Stockholm, Sweden; 2Department of Medicine, Montefiore Medical Center, The University Hospital of Albert Einstein School of Medicine, Bronx, NY; 3Department of Molecular & Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, - - 2014
To investigate the time-course of autonomic tone changes after a first-time endurance running race participation and associations with post-exertional high-sensitivity troponin (hsTnT) levels in middle-aged males. Male (n=42) first time long distance running race (Lidingöloppet 30km) participants ≥45 years (50.5±5) were studied. Heart rate (HR) and heart rate variability (HRV) ...
Lange Richard A RA Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Dr., MC 7870, San Antonio, TX, 78229-3900, USA, - - 2014
Human sexuality is an important aspect of health and quality of life. Many patients with ischemic heart disease - and their partners - are concerned that sexual activity could exacerbate their cardiac condition, possibly causing myocardial infarction or cardiac death. Patients with ischemic heart disease who wish to initiate or ...
Nie J J School of Physical Education and Sports Macao Polytechnic Institute, Macao, China - - - 2014
Background: Prolonged exercise may induce a transient reduction in the left ventricular (LV) function (exercise-induced cardiac fatigue) in adults. However, data related to the cardiovascular consequences of prolonged exercise in adolescents are extremely limited. This study examined the impact of exercise intensity adopted in routine long-distance run training on LV ...
Schuler Beat B Institute of Veterinary Physiology, Vetsuisse Faculty University of Zürich; Department of Physiology, Anatomy and Genetics, University of Oxford, Great - - 2014
It is unknown how the heart distinguishes various overloads, such as exercise or hypertension, causing either physiological or pathological hypertrophy. We hypothesize that alpha calcitonin gene-related peptide (αCGRP), known to be released from contracting skeletal muscles, is key at this remodeling. The hypertrophic effect of αCGRP was measured in vitro ...
Kaye David D Baker IDI Heart and Diabetes Institute and Alfred Hospital, Melbourne, - - 2014
A treatment based on an interatrial shunt device has been proposed for counteracting elevated pulmonary capillary wedge pressure (PCWP) in patients with heart failure and mildly reduced or preserved ejection fraction (HFpEF). We tested the theoretical hemodynamic effects of this approach using a previously validated cardiovascular simulation model. Rest and ...
Finocchiaro Gherardo G Stanford University School of Medicine, Department of Medicine, Division of Cardiovascular Medicine. Electronic address: - - 2014
Exercise echocardiography is a reliable tool to assess left ventricular (LV) dynamic obstruction in hypertrophic cardiomyopathy (HCM). The aim of our study was to determine the role of exercise echocardiography in the evaluation of latent obstruction and in predicting clinical deterioration in HCM patients. We considered 283 HCM patients studied ...
Lee Gino G Department of Cardiology; Cardiovascular Research Institute Basel - - 2014
Myocardial ischemia has been shown to be associated with increased levels of B-type natriuretic peptide (BNP). However, it remains unclear whether and how BNP levels could be used clinically in patients with suspected exercise-induced myocardial ischemia. We enrolled 274 consecutive patients with suspected exercise-induced myocardial ischemia referred for evaluation by ...
Murninkas Daniel D Heart Failure/Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address: - - 2014
Right ventricular ejection fraction (RVEF) is a mortality predictor in heart failure (HF) patients. There are controversial results regarding the influence of RVEF on other important prognostic variables. The purpose of this study was to investigate the effect of RVEF on exercise parameters obtained during cardiopulmonary exercise testing (CPET), creatinine, ...
D'Ascenzi Flavio F 1Department of Cardiovascular Diseases, University of Siena, Siena, - - 2014
-Exercise is able to induce atrial remodelling in top-level athletes. However, evidence is mainly limited to men and based on cross-sectional studies. The aim of this prospective, longitudinal study was to investigate whether exercise is able to influence left (LA) and right atrial (RA) morphology and function also in female ...
Meluzin Jaroslav J Department of Cardiovascular Diseases, ICRC, St. Anne's Hospital in Brno, Czech - - 2014
Post-heart transplant patients are at increased risk of diastolic dysfunction. The aim of this study was to assess the prevalence of isolated only exercise-induced heart failure with normal ejection fraction (HFNEF) in heart transplant recipients. To determine pulmonary capillary wedge pressure (PCWP) at rest and during exercise, 81 patients after ...
Tian Ye Y China Institute of Sport Science , Beijing , China - - 2014
Abstract We examined the reproducibility of alterations in cardiac biomarkers after two identical bouts of prolonged exercise in young athletes. Serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were assessed before and after exercise. Significant rises in median hs-cTnT and NT-proBNP occurred in both trials. ...
Stanton Tony T University of Queensland, Brisbane, - - 2014
The optimal method of cardiac resynchronization therapy (CRT) optimization is as yet unknown. We sought to investigate the responses of optimization at rest and on exercise. This 2 stage study involved 59 patients (age 65 ± 10, 75% male), who had all recently undergone successful CRT implantation. In the first stage, the ...
Critoph Christopher H CH The Heart Hospital, Institute for Cardiovascular Science, University College London, , London, - - 2014
Reduction of left ventricular outflow tract obstruction (LVOTO) often improves symptoms in hypertrophic cardiomyopathy (HCM), but the correlation between exercise performance and measured LVOT gradients is weak. We investigated the relationship between LVOTO and cardiorespiratory responses during exercise. The study cohort included 70 patients with HCM (32 with LVOTO, 55 ...
Chen Chun-An CA Department of Pediatrics, National Taiwan University Hospital, Taipei, - - 2014
Right ventricular (RV) outflow tract obstruction (RVOTO) might protect the RV from adverse remodeling caused by significant pulmonary regurgitation (PR) in patients with repaired tetralogy of Fallot (rTOF), but the underlying mechanisms and influences on exercise tolerance remain unclear. This study sought to investigate the impacts from mild RVOTO on ...
Hirai Daniel M DM Kansas State - - 2014
Chronic heart failure (CHF) impairs nitric oxide (NO)-mediated regulation of skeletal muscle O2 delivery-utilization matching such that microvascular oxygenation falls faster (i.e., speeds PO2mv kinetics) during increases in metabolic demand. Conversely, exercise training improves (slows) muscle PO2mv kinetics following contractions onset in healthy young individuals via NO-dependent mechanisms. We tested ...
Predel Hans-Georg HG Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, Cologne 50933, - - 2014
The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One ...
Zurek Marzena M Division of Cardiology, Kantonsspital St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, - - 2014
Midregional pro-adrenomedullin (MR-proADM) and C-terminal pro-vasopressin (copeptin) are novel biomarkers providing prognostic information in various settings. We aimed to (1) assess the kinetics of MR-proADM and copeptin during cardiopulmonary exercise testing (CPET); (2) assess the relationship of MR-proADM and copeptin measured at rest with peak oxygen consumption (peak VO2) and ...
Eijsvogels Thijs M H TM Department of Physiology, Radboud University Medical Centre, Nijmegen, The Netherlands; Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT, USA. Electronic address: - - 2014
Exercise leads to an increase in cardiac troponin I in healthy, asymptomatic athletes after a marathon. Previous studies revealed single factors to relate to post-race cardiac troponin I levels. Integrating these factors into our study, we aimed to identify independent predictors for the exercise-induced cardiac troponin I release. Observational study. ...
Deboeck Gaël G Erasmus University Hospital, Department of Cardiology, Université Libre de Bruxelles, Brussels, - - 2014
The 6 minutes walk test (6MWT) is often shown to be the best predictor of mortality in pulmonary hypertension (PH) probably because it challenges the failing heart to deliver adequate cardiac output. We hypothesised that the 6MWT elicits maximal cardiac output as measured during a maximal cardiopulmonary exercise testing (CPET). ...
Asrar Ul Haq Muhammad M Department of Cardiology, The Northern Hospital, Melbourne, Australia. ; Austin Health, Melbourne, Australia. ; Department of Medicine, University of Melbourne, Melbourne, - - 2014
This study will examine the effects of combined aerobic and resistance training on left ventricular remodeling in diabetic patients with diastolic dysfunction. This is the first randomized controlled trial to look for effects of combined strength training and aerobic exercise on myocardial function as well as other clinical, functional, or ...
Nytrøen Kari K Kari Nytrøen, Lars Gullestad, Department of Cardiology, Oslo University Hospital, Rikshospitalet, 0424 Oslo, - - 2013
While life expectancy is greatly improved after a heart transplant, survival is still limited, and compared to the general population, the exercise capacity and health-related quality of life of heart transplant recipients are reduced. Increased exercise capacity is associated with a better prognosis. However, although several studies have documented positive ...
Boos Christopher John CJ Department of Cardiology, Poole Hospital NHS Foundation Trust, Longfleet Rd. Poole, Dorset, BH15 2JB, UK, - - 2013
It has been consistently shown that heavy exercise leads to cardiac troponin (cTn) release and variable changes in post exercise cardiac function. This relationship has not been explored at increasing or significant high altitude (HA). This study assessed the effects of exercise at progressively increasing HA on high-sensitivity (hs)-cTnT levels ...
Mooren Frank C FC Institute of Sports - - 2013
Purpose MicroRNAs (miRs) are crucial intracellular mediators of various biological processes, also affecting the cardiovascular system. Recently, it has been shown that microRNAs circulate extracellularly in the bloodstream and that such circulating microRNAs change in response to physical activity. Therefore the purpose of the current study was to investigate heart/muscle ...
Athanasios Tasoulis T 1(st) Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, "Evgenidio" Hospital, NKUA, Athens, - - 2013
Patients with chronic heart failure (CHF) are characterized by exercise intolerance and ventilatory abnormalities that are related to poor prognosis. We hypothesized that CHF patients have increased respiratory drive and abnormal breathing pattern during exercise in relation to disease severity. The study population consisted of 219 stable CHF patients and ...
Azarbal Farnaz - - 2013
Atrial fibrillation (AF) is the most common arrhythmia among patients with hypertrophic cardiomyopathy (HCM). The relationship between paroxysmal AF and exercise capacity in this population is incompletely understood. Patients with HCM underwent symptom-limited cardiopulmonary testing with expired gas analysis at Stanford Hospital between October 2006 and October 2012. Baseline demographics, ...
Neal Jennifer E - - 2013
Submaximal exercise testing (SET) assesses functional exercise capacity in pulmonary arterial hypertension (PAH) patients and provides additional physiologic information compared to the six minute walk test (6MWT). The relative correlations of the 6MWT and SET using SHAPE-HF™ with other markers of PAH severity, particularly echocardiogram (ECHO)-derived mean pulmonary artery pressure ...
Kooiman Kirsten M - - 2013
Inappropriate shocks (IAS) complicate implantable cardioverter defibrillator (ICD) therapy. The management of IAS in patients with a subcutaneous ICD (S-ICD) differs from conventional ICDs because of different sensing algorithms and programming options. To describe the management of IAS in patients with a S-ICD. Patients were implanted with a S-ICD between ...
Borlaug Barry A - - 2013
Approximately half of patients with heart failure (HF) have a preserved ejection fraction (HFpEF), and with the changing age and comorbidity characteristics in the adult population, this number is growing rapidly. The defining symptom of HFpEF is exercise intolerance, but the specific mechanisms causing this common symptom remain debated and ...
Hindiyeh Nada Ahmad - - 2013
Many non-pharmacological treatments have been implicated in the treatment of primary headache, with exercise being a common recommendation. In this review we first provide an overview of the relationship between exercise and primary headaches. We then review the physiology of pain modulation, with focus on the endogenous opioids, endocannabinoids, and ...
Reed Jennifer L - - 2013
Atrial fibrillation, the most common sustained cardiac arrhythmia, is associated with significant morbidity and mortality. Chronic exercise training is a recognized form of treatment for those with many forms of heart disease. There might also be a role for exercise in the management of permanent atrial fibrillation; few studies have ...
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