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Results 401 - 450 of 1394
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Diehm Curt - - 2011
We aimed to investigate whether the post-exercise ankle brachial index (ABI) performed by primary care physicians offers useful information for the prediction of death or cardiovascular events, beyond the traditional resting ABI. An additional focus was on patients with intermittent claudication and normal resting ABI. Using data from the 5-year ...
Ghafouri Samireh - - 2011
Insulin is a potent vasoactive hormone which induces vasodilatation at physiological concentrations. Aerobic exercise is known to improve insulin vasodilatory activity in humans and experimental animals. Since both insulin and physical training is known to activate K(ATP) and K(Ca2+) channels and increase nitric oxide (NO) synthesis, we hypothesized that insulin ...
Wallberg Linnea - - 2010
Interleukin 6 (IL-6) response was studied during two ultra endurance events-one laboratory 24 h protocol (9 men) with exercise intensity set to 60% of VO(2max) and one Adventure Race over 6 days (12 men/6 women) with a self-selected race pace, including rests, of about 38% of VO(2max). In the 24-h protocol IL-6 ...
Puente-Maestu Luis - - 2011
Background Exhausting exercise reduces the mitochondrial DNA (mtDNA) content in the skeletal muscle of healthy subjects due to oxidative damage. Since patients with chronic obstructive pulmonary disease (COPD) suffer enhanced oxidative stress during exercise, it was hypothesised that the mtDNA content will be further reduced. Objective To investigate the effects ...
Lee-Young R S - - 2011
Objective:Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin-resistant individuals during exercise. We determined whether this defect contributes to the metabolic dysregulation and reduced exercise capacity observed in the obese state.Design:C57BL/6J wild-type (WT) mice and/or mice expressing a kinase dead AMPKα2 subunit in skeletal muscle (α2-KD) were ...
Tsuchimochi Hirotsugu - - 2011
We investigated the contribution of tetrodotoxin (TTX)-resistant sodium channels to the augmented exercise pressor reflex observed in decerebrated rats with femoral artery ligation. The pressor responses to static contraction, to tendon stretch, and to electrical stimulation of the tibial nerve were compared before and after blocking TTX-sensitive sodium channels on ...
Pechlivanis Alexandros - - 2010
Physical exercise modifies animal metabolism profoundly. Until recently, biochemical investigations related to exercise focused on a small number of biomolecules. In the present study, we used a holistic analytical approach to investigate changes in the human urine metabolome elicited by two exercise sessions differing in the duration of the rest ...
Giannaki Christoforos D - - 2010
Restless legs syndrome (RLS) is very common in hemodialysis patients. RLS induces motor excitability and discomfort during rest periods, and those symptoms have also been observed during hemodialysis sessions. The aim of the study was to assess whether a single bout of exercise could reduce periodic limb movements (PLM) occurring ...
Glover Elisa I - - 2010
Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a randomized, double-blind, cross-over trial. Blood lactate, urinary ...
Scheinowitz Mickey - - 2011
Previous studies have reported ambiguous results regarding the effect of acute exercise on platelet reactivity in healthy and cardiac patients. We aimed to assess platelet reactivity among diabetic patients before and immediately after an acute exercise stress test. Patients (controls: mean age 53.1±12.1 years; four males; body mass index 27.0±5.7 ...
Tenan Matthew S - - 2011
Local muscle fatigue may be related to potassium efflux from the muscle cell and/or lactate accumulation within the muscle. Local fatigue causes a decrease in median frequency (MPF) of the electromyogram's power spectrum during isometric contractions but its relationship to changes in potassium and lactate during dynamic exercise is equivocal. ...
Ciammola Andrea - - 2011
Mitochondrial defects that affect cellular energy metabolism have long been implicated in the etiology of Huntington's disease (HD). Indeed, several studies have found defects in the mitochondrial functions of the central nervous system and peripheral tissues of HD patients. In this study, we investigated the in vivo oxidative metabolism of ...
Sibold Jeremy S - - 2010
The objective was to estimate the duration of the effects of aerobic exercise on mood. Healthy men (n = 13) and women (n = 35) ages 18 to 25 years (M = 20.2, SD = 3.4) were randomly assigned to either a control or exercise group. Participants completed the Profile ...
Babwah T J R - - 2010
There are many benefits of regular exercise. The aim of this study was to determine the exercise habits and knowledge of the benefits of exercise in a south Trinidad population. This study also sought to determine the motivating factors for exercise and the barriers experienced by those who did not ...
Dalbo Vincent J - - 2010
This investigation examined the safety and efficacy of a silica-based mineral antioxidant complex (MAC) that has been suggested to influence body water and buffer lactate. In a double-blind, randomized crossover design, male participants completed testing for 3 conditions: water only (baseline), rice flour (placebo), and MAC supplementation. Participants visited the ...
Spanoudaki S - - 2010
Intense and prolonged exercise greatly affects circulating cytokine levels. The purpose of this study was to investigate the possible changes in tumour necrosis factor -a (TNF-a), interleukin 6 (IL-6) and cortisol concentrations during and after prolonged exercise of constant and alternating intensity of the same duration and total work performed. ...
Toste Alexandra - - 2010
Cardiopulmonary exercise testing (CPET) is an objective method for assessment of functional capacity and for prognostic stratification of patients with chronic heart failure (CHF). In this study, we analyzed the prognostic value of a recently described CPET-derived parameter, the minute ventilation to carbon dioxide production slope normalized for peak oxygen ...
Guellich Arne - - 2010
To compare the intensity distribution during cycling training among elite track cyclists who improved or decreased in ergometer power at 4 mM blood lactate during a 15 wk training period. 51 young male German cyclists (17.4 ± 0.5 y; 30 international, 21 national junior finalists) performed cycle ergometer testing at ...
Josefsen Knud - - 2010
We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P < ...
Sahin Sevki - - 2010
Although the pathogenesis of migraine still remains unclear, certain metabolic studies done on patients with migraine indicate possible deficits in mitochondrial activity. Previously, the forearm ischemic exercise test (FIT) has been used as a screening tool to evaluate mitochondrial dysfunction in metabolic myopathies. We studied the response of migraine patients ...
de Almeida Rosemeire Dantas - - 2010
During exercise, ammonia levels are related to the appearance of both central and peripheral fatigue. Therefore, controlling the increase in ammonia levels is an important strategy in ameliorating the metabolic response to exercise and in improving athletic performance. Free amino acids can be used as substrates for ATP synthesis that ...
Menzies Paul - - 2010
High-intensity exercise training contributes to the production and accumulation of blood lactate, which is cleared by active recovery. However, there is no commonly agreed intensity or mode for clearing accumulated blood lactate. We studied clearance of accumulated blood lactate during recovery at various exercise intensities at or below the lactate ...
Brown Peter I - - 2010
PURPOSE: The purpose of this study was to investigate the effects of inspiratory threshold loading (ITL) and inspiratory muscle training (IMT) on blood lactate concentration ([lac(-)]B) and acid-base balance after maximal incremental cycling. METHODS: Eighteen subjects were divided into a control (n = 9) or an IMT group (n = ...
Rimaud Diana - - 2010
This study aimed to investigate if wearing compression stockings (CS) during exercise and recovery could affect lactate profile in sportsmen. Eight young healthy trained male subjects performed two maximal exercise tests on a cycle ergometer on two different occasions performed randomly: CS during both exercise and recovery, and no CS. ...
Simões Rodrigo P - - 2010
The objective of this study was to (a) evaluate the impact of the leg press, at variable percentages of 1 repetition maximum (1RM), on heart rate variability (HRV) and blood lactate and (b) determine the relationship between HRV with blood lactate in a healthy elderly cohort. Ten healthy men (64 ...
Beneke Ralph - - 2010
A model that describes the blood lactate concentration (BLC) dynamics [BLC(t)] of a Wingate Anaerobic Test (WAnT) as a function of (a) BLC at the start of exercise (BLC(0)), (b) extra-vascular increase in lactate (A), (c) two corresponding velocity constants of appearance (k (1)) and disappearance (k (2)) of lactate ...
Tolfrey Keith - - 2010
Fatmax and lactate increase above baseline (LIAB) were measured in 11 adolescent girls and 8 adolescent boys during incremental cycling. Fatmax was the exercise intensity at the point of maximal fat oxidation rate (MFO). The LIAB was the exercise intensity coincident with a sustained increase in blood (lactate) above an ...
Tudorache C - - 2010
The effect of flume length and impingement time on post-exercise lactate concentrations in brook charr Salvelinus fontinalis were examined. Swimming in longer flumes increased lactate concentrations, as does impingement after swimming in short flumes.
Barbosa Tiago M - - 2010
The purpose of this study was to analyze the relationships between musical cadence and the physiologic adaptations to basic head-out aquatic exercises. Fifteen young and clinically healthy women performed, immersed to the breast, a cardiovascular aquatic exercise called the "rocking horse." The study design included an intermittent and progressive protocol ...
Tutkun Erkut - - 2010
The aim of the present study is to understand the basic relationship between swimming exercise and natural course of epilepsy in animals by performing an electrophysiological study. For this purpose, male Wistar rats were submitted to daily swimming exercise program of three different durations. Animals were swim-exercised for 90 days ...
Zdrenghea D - - 2010
The best evaluation of the severity and prognosis of heart failure patients is obtained by the maximal exercise stress testing, but for the very large number of HF patients and for evaluation of their daily effort capacity submaximal stress testing, mainly 6 minutes walking test are used. The limit of ...
Jeukendrup Asker E - - 2010
Background/Aims: Carbohydrate ingested 30-60 min before exercise may result in hypoglycaemia during exercise, a phenomenon often called rebound or reactive hypoglycaemia. There is considerable confusion regarding pre-exercise carbohydrate feeding with advice that ranges from 'consume carbohydrate in the hour before exercise' to 'avoid carbohydrate in the 60 min prior to ...
Kimura Takehide - - 2010
The aim of this study was to determine whether the increase in blood volume in resting muscle during moderately prolonged exercise is related to heart rate (HR) upward drift. Eight healthy men completed both arm-cranking moderately prolonged exercise (APE) and leg-pedaling moderately prolonged exercise (LPE) for 30 min. Exercise intensity ...
Perciavalle Valentina - - 2010
Gender differences in cortical excitability have been detected by using transcranial magnetic stimulation (TMS). The present study was carried out to compare the effects of high blood lactate levels, induced by performing a maximal exhausting exercise, on the excitability of the primary motor cortex in young male and female athletes. ...
Karinen Heikki M - - 2010
Acute mountain sickness (AMS) is a common problem while ascending at high altitude. AMS may progress rapidly to fatal results if the acclimatization process fails or symptoms are neglected and the ascent continues. Extensively reduced arterial oxygen saturation at rest (R-Spo₂) has been proposed as an indicator of inadequate acclimatization ...
Ferreira Clílton K O - - 2010
To analyze the effects of exhausting long-duration physical exercise (swimming) sessions of different durations and intensities on the number and phagocytic capacity of macrophages and neutrophils in sedentary rats. Exercise intensity, duration and frequency are important factors in determining immune response to physical effort. Thus, the effects of exhausting long-duration ...
Buono Michael J - - 2010
The purpose of this study was to determine the effect of increases in exercise intensity on the sweat lactate concentration and lactate excretion rate. Eight healthy male volunteers complete a 90-min exercise bout of treadmill walking in a 35 degrees C and 40% relative humidity environmental chamber. During the exercise ...
Macedo Denise Vaz - - 2009
The cause-effect relationship between lactic acid, acidosis, and muscle fatigue has been established in the literature. However, current experiments contradict this premise. Here, we describe an experiment developed by first-year university students planned to answer the following questions: 1) Which metabolic pathways of energy metabolism are responsible for meeting the ...
Cupeiro Rocío - - 2010
Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high ...
Caruso John F - - 2009
Acceleration, or an increase in the rate of movement, is integral to success in many sports. Improvements in acceleration often entail workouts done at intensities that elicit higher blood lactate concentrations (BLa). The purpose of the study is to assess the impact of acceleration on BLa. Methods required subjects (n ...
Coco Marinella - - 2009
The accumulation of lactate in the blood after a high-intensity exercise is associated to an increase of lactate extractions by the brain. However, no information has been provided about the influences of blood lactate on cognitive performances and, in particular, on attention. The present study was carried out to examine ...
Bortolini Miguel Junior Sordi - - 2009
Saliva provides a convenient and noninvasive matrix for assessing specific physiological parameters, including some biomarkers of exercise. We investigated whether the total protein concentration of whole saliva (TPWS) would reflect the anaerobic threshold during an incremental exercise test. After a warm-up period, 13 nonsmoking men performed a maximum incremental exercise ...
Komaki Hirofumi - - 2010
BACKGROUND: Recently we proposed the therapeutic potential of pyruvate therapy for mitochondrial diseases. Leigh syndrome is a progressive neurodegenerative disorder ascribed to either mitochondrial or nuclear DNA mutations. METHODS: In an attempt to circumvent the mitochondrial dysfunction, we orally applied sodium pyruvate and analyzed its effect on an 11-year-old female ...
Wilkerson Daryl P - - 2009
We hypothesised that dichloroacetate (DCA) would reduce blood lactate accumulation, pulmonary carbon dioxide output (.V(CO2)) and ventilation (.V(E)) at sub-maximal work rates, and improve exercise tolerance during incremental exercise in healthy humans. Nine males (mean+/-SD, age 27+/-4 years) completed, in random order, two ramp incremental cycle ergometer tests to the ...
Garner Dena P - - 2009
Research has described the use of mouthpieces not only in preventing oral-facial injuries, but linking use to improvements in muscular strength and endurance. However, the mechanisms by which these improvements occur have not been elucidated. The purpose of this study was to understand possible physiological explanations for improvements in exercise ...
Baudry Stéphane - - 2009
Ten adolescent judokas performed circuit training consisting of six 40-s periods ofjudo exercises separated by 40 s (CT1:1), 120 s (CT1:3), or 200 s (CT1:5) of rest. Heart rate, blood lactate concentration, and the number of repetitions were recorded. Heart rate reached approximately 180 beats x min(-1) at the end ...
van Hall Gerrit - - 2009
Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion ...
Simões H G - - 2009
AIM: The lactate minimum (LM) protocol has been used to assess aerobic fitness and to predict exercise intensity associated with the maximal blood lactate steady state. The aim of this study was to compare different methods to identify the lactate minimum velocity (LMV) on cycling. METHODS: Fourteen male cyclists (26.8+/-4.5 ...
Sfakianakis D G - - 2010
Muscle lactate metabolic recovery in sea bass juveniles was studied in respect to the water temperature. The fish used in this study were cultured with the semi-extensive mesocosm method, and the water temperatures were 15 and 20 degrees C. Fish were led to exhaustion by exercising in a swimming channel, ...
Faude Oliver - - 2009
During the last nearly 50 years, the blood lactate curve and lactate thresholds (LTs) have become important in the diagnosis of endurance performance. An intense and ongoing debate emerged, which was mainly based on terminology and/or the physiological background of LT concepts. The present review aims at evaluating LTs with ...
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