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Results 501 - 550 of 727
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Anastasiou-Nana M I - - 1987
Flecainide acetate, a new antiarrhythmic agent, possesses favorable pharmacokinetic and hemodynamic properties and demonstrates highly favorable antiarrhythmic activity in patients with ventricular arrhythmias. However, the proarrhythmic potential of flecainide deserves further evaluation. In 7 (13%) of 55 consecutive patients treated with oral flecainide, 200 to 600 mg/day, for complex ventricular ...
Iwase M - - 1987
To estimate the effects of diltiazem on the left ventricular diastolic abnormalities in patients with hypertrophic cardiomyopathy, transmitral flow velocity during diastole was studied before and immediately after dynamic leg exercise with the pulsed Doppler technique combined with two-dimensional echocardiography. Seventeen patients with hypertrophic cardiomyopathy and 24 apparently healthy men ...
Rasmussen K - - 1987
Among 400 consecutive patients undergoing conventional isolated bypass surgery, 9 patients had clinical and electrocardiographic evidence of severe ischaemia during exercise and serious exercise-induced ventricular arrhythmias. Four patients had spontaneous exercise-induced arrhythmias and two had been resuscitated for out-of-hospital cardiac arrest. Postoperatively all patients were free of angina, off anti-anginal ...
Hanson P - - 1987
Isometric exercise produces a characteristic pressor increase in blood pressure which may be important in maintaining perfusion of muscle during sustained contraction. This response is mediated by combined central and peripheral afferent input to medullary cardiovascular centers. In normal individuals the increase in blood pressure is mediated by a rise ...
Cleland J G - - 1987
Twenty two patients with heart failure were studied in a double blind crossover trial to compare amiodarone (200 mg/day) with placebo. Each agent was given for three months. Extrasystoles and complex ventricular arrhythmias were common during ambulatory electrocardiographic monitoring and during exercise testing at entry to the study. Breathlessness and ...
Trezona P W - - 1987
Although the results of the 2 degrees Stiles-Burch investigation were published in 1955 in the form of mean data, individual results have not been available. It is only recently that they have been in wide demand. Since in 1955 this demand was not anticipated, individual results were left in an ...
Bause G S - - 1987
Although hypertensive patients have been shown to have a higher prevalence of arrhythmias during ambulatory monitoring when treated with diuretic drugs than when untreated, the effects of maximal aerobic stress on arrhythmia frequency in such patients is unknown. The incidence of arrhythmias during graded maximal treadmill exercise in a group ...
Niemelä K - - 1987
Digitized M mode echocardiography was used to evaluate the effect of a competitive 24-h run on the left ventricular diastolic function in 12 well-trained marathon runners who completed 146-227 km during the race. Mitral valve opening was delayed, early diastolic filling was decreased and prolonged, and posterior wall thinning was ...
Hosenpud J D - - 1987
To determine the effects of exercise in experimental autoimmune myocarditis, guinea pigs immunised with heterologous heart protein (rat heart), Freund's complete adjuvant, and pertussis vaccine (treated group) were exercised on a treadmill for a total of 11 weeks and compared with non-exercise treated animals. In vivo heart rates and pressures, ...
Iida K - - 1987
The influence of exercise on left ventricular diastolic filling was evaluated in 14 patients with hypertrophic cardiomyopathy (HCM) and 14 normal controls (NC) by dynamic exercise echocardiography. Using X-Y digitizer and computer, normalized peak rate of change of the left ventricular dimension during systole (pVs) and the rapid filling phase ...
White F C - - 1987
Cardiac functional and structural adaptations to exercise-induced hypertrophy were studied in 68 pigs. Pigs were exercise trained on a treadmill for 10 wk. Sequential measurements were made of cardiac dimensions, [left ventricular end-diastolic diameter (EDD), changes in diameter (delta D%), wall thickness (WTh), wall thickening (WTh%), left ventricular pressure (LVP), ...
Piérard L A - - 1987
M mode echocardiography was used in 10 normal subjects to study left ventricular dimension and function variables at identical heart rates during tachycardia induced by supine bicycle exercise or atrial pacing. Echocardiographic data were analysed independently by two observers. The maximum heart rate reached during atrial pacing was lower (mean ...
Oyen E M - - 1987
To evaluate left ventricular reserve in normal children 127 healthy boys and girls (71 males, 56 females) were investigated with echocardiography during supine bicycle exercise at levels of 6, 9, 12 and 15 kpm/min/kg body weight. Left ventricular function parameters were obtained from the M-mode echocardiogram, electrocardiogram and phonocardiogram. The ...
Yasuda M - - 1987
The left ventricular function of patients with essential hypertension was examined during exercise and isoproterenol (ISP) infusion echocardiography. Twenty-eight hypertensive patients without cardiac hypertrophy (Group NH), 20 patients with cardiac hypertrophy (Group HH), 7 patients with cardiac dilatation (Group D), and 13 normotensives (Group N), were studied during multistage exercise ...
Steinberg J S - - 1987
Although digoxin is often the first choice for control of ventricular response in chronic atrial fibrillation, it fails to slow exercise rates. Diltiazem, a calcium channel antagonist that slows atrioventricular conduction, was administered to 16 patients who failed to achieve adequate rate control on low level exercise testing despite digoxin ...
Barzilay J - - 1987
Between the years 1981-1984, 89 air-personnel, ages 18-45 years, underwent 24-hour ambulatory ECG monitoring at the Israel Air Force Aeromedical Center due to an incidental finding of one or more premature ventricular contractions (PVCs) on the resting supine 12-lead ECG. Complex ectopic arrhythmias (bigemini, trigemini, couplets, ventricular tachycardia, R on ...
Bryhn M - - 1987
Ten patients with hypertrophic cardiomyopathy were examined with echocardiography before and during verapamil treatment to evaluate short-term and long-term effects of verapamil on left ventricular diastolic function. All patients were in sinus rhythm and in NYHA functional class I. Effects on filling and myocardial relaxation were documented by digitized echocardiography ...
Stroobandt R - - 1987
The antiarrhythmic efficacy of transcainide has been studied in 41 patients. It abolished ventricular arrhythmias in 10 out of 12 patients after i.v. administration and in 11 out of 14 after oral administration. It also reduced ventricular arrhythmias during recovery from exercise. The maximum intravenous dose prolonged the PR-interval by ...
Waldrop T G - - 1987
Conscious cats performing static (isometric) exercise were studied before and after administration of the opiate antagonist naloxone in order to evaluate the possible role of endogenous opiates in regulating cardiovascular responses to static exercise. Intravenous administration (0.4 mg/kg) of naloxone had no effect on resting left ventricular systolic pressure or ...
Majid P A - - 1986
We describe the clinical course of a patient with tachycardia at rest, biopsy proven dilated cardiomyopathy, and moderately severe left ventricular systolic dysfunction. Short-term use of pindolol produced a significant fall in heart rate and cardiac output at rest and during exercise. However, after addition of pindolol to the patient's ...
Sato T - - 1986
A 40-year-old housewife was observed with chief complaints of syncope and palpitation. The electrocardiogram indicated premature ventricular ectopic complexes of the torsade de pointes. Serum potassium level was low because of thiazide-induced hypokalemia for the treatment of transient hypertension. Even after the disappearance of threatening ventricular arrhythmias and normalization of ...
Holt P - - 1986
Previous work from the Departments of Cardiology and Nuclear Medicine, Guy's Hospital, London, has enabled an atlas of the electrocardiographic appearances of ectopics from individual ventricular sites to be compiled. This has been used to investigate the relationship between regions of myocardial ischaemia and the site of origin of exercise-induced ...
Morrison D A - - 1986
The cardiovascular effects of physical training were evaluated in a controlled trial involving 32 healthy, untrained, postmenopausal women. The subjects were randomly assigned to an aerobic exercise training program or a control group. The exercise group participated in at least three 40-minute supervised sessions per week for 8 months. Twenty-five ...
Battler A - - 1986
The effect of metoprolol on global left ventricular function during exercise was analyzed with nuclear ventriculography in 17 patients with ischemic heart disease. All had stable angina pectoris and ST-segment depression of more than 0.1 mV during treadmill exercise when not taking metoprolol. Each patient was stressed with supine bicycle ...
Sokoloff N M - - 1986
The relation between plasma norepinephrine levels and the occurrence of ventricular tachycardia during exercise testing was prospectively evaluated in 17 patients. Ten patients had reproducible ventricular tachycardia exclusively during exercise or recovery, or both; 7 patients had ventricular tachycardia only during ambulatory electrocardiographic monitoring. The two groups did not differ ...
Seals A A - - 1986
To evaluate the hemodynamic effects of moricizine, 20 patients with frequent nonsustained ventricular tachycardia (VT) with a mean left ventricular ejection fraction (EF) of 39 +/- 14% were enrolled in a prospective single-blind, placebo-controlled study. Hemodynamic measurements were performed at rest and during supine bicycle exercise on placebo and moricizine ...
Gwirtz P A - - 1986
Modulation of coronary blood flow and cardiac function by alpha 1-adrenergic receptors was examined in dogs during strenuous exercise. Fifteen dogs were chronically instrumented to measure left circumflex blood flow, heart rate, regional left ventricular function (systolic shortening, and rate of shortening), and global left ventricular function (left ventricular pressure, ...
Martin W H WH - - 1986
To determine the role of preload in maintaining the enhanced stroke volume of upright exercise-trained endurance athletes after deconditioning, six highly trained subjects undergoing upright and supine bicycle ergometry were characterized before and after 3, 8 and 12 weeks of inactivity that reduced oxygen uptake by 20%. During exercise, oxygen ...
Choong C Y - - 1986
The effects on hemodynamics and left ventricular function of propranolol and pindolol, beta-blockers without and with intrinsic sympathomimetic activity (ISA), respectively, were compared in six men with stable exertional angina at rest and during symptom-limited bicycle exercise. The study was controlled and double blinded, and the order of drug administration ...
Yokota M - - 1986
Multistage bicycle ergometer exercise testings with Frank vectorcardiogram and M-mode echocardiogram were performed on 12 patients with effort angina pectoris. The left atrial and left ventricular end-diastolic volume (LAV and LVEDV) were calculated as a cube of the left atrial and left ventricular end-diastolic dimension. The mean pulmonary artery wedge ...
Agostoni P G - - 1986
Nifedipine and captopril are potent vasodilators and may be expected to help left ventricular failure by reducing afterload. Nifedipine (20 mg three times a day) and captopril (50 mg three times a day) were added to an optimal regimen of digitalis and diuretics in a double blind crossover trial in ...
Weber K T - - 1986
Symptoms of dyspnea and fatigue limit effort tolerance in patients with chronic cardiac failure. These symptoms may be consequent to an abnormal cardiocirculatory response to the increased O2 demand that accompanies exercise as manifested by: reduced ability to augment cardiac output in response to increased left ventricular filling pressure, inadequate ...
Holt P M - - 1986
We have investigated 13 patients with monomorphic ventricular tachycardia which originated from the right ventricular outflow tract. No patient had evidence of organic heart disease. There were 3 males and 10 females, aged 13-53 years. All had non-invasive investigations including an exercise electrocardiogram, chest radiography, echocardiograms and gated blood pool ...
Ekelund L G - - 1986
The efficacy of disopyramide compared to placebo for exercise induced ventricular arrhythmias was tested in a double-blind randomized controlled clinical trial with cross-over design in 14 patients with coronary heart disease. Disopyramide was given as ordinary capsules (q.i.d.) or as a slow release preparation (b.i.d.) in a total dose of ...
Armiger L C - - 1986
The regional distribution of energy-related metabolites was determined for the normal dog heart by using high performance liquid chromatography to analyse the levels of ATP, ADP, AMP, IMP, adenosine, inosine, hypoxanthine/xanthine, uric acid and NAD in tissue samples from 7 defined areas of the myocardium and 2 of the conduction ...
Haerem J W - - 1985
Some adverse effects of beta-blockers in heart failure are counteracted by glycerylnitrate. However, the hemodynamics in this condition after giving both drugs are not well known. We examined the drug combination in exercising coronary patients with left ventricular dysfunction. Elevated left ventricular end-diastolic pressure was a measure of dysfunction. A ...
Hannon J D - - 1985
We studied 24 patients who had a graded exercise test 1 to 16 years after correction of tetralogy of Fallot. Maximal oxygen consumption was subnormal in 19 of the patients. We found no relationship between age at repair, postoperative right ventricular pressure, right ventricular-to-pulmonary artery pressure gradient, or ratio of ...
Cohen J L - - 1985
Left ventricular dimensions measured by M-mode echocardiography of 10 distance runners and 10 wrestlers were compared to 10 sedentary controls at rest and during 12 min of semisupine, graded bicycle ergometer exercise. At rest, runners and wrestlers demonstrated greater left ventricular mass compared to controls (mean values, 311.8 and 325.9 ...
Jervell A - - 1985
The first diagnosed cases of the surdo-cardiac syndrome are presented. The effect on the ECG of exercise, of digitalis treatment, of intramuscular injection of atropine and of intravenous injection of potassium chloride solution were studied. ECGs taken during attacks of syncope showed that the attacks are caused either by ventricular ...
Bonow R O - - 1985
Verapamil improves exercise tolerance and decreases symptoms in many patients with hypertrophic cardiomyopathy. The mechanisms responsible for these effects are not completely understood, although previous studies indicate that verapamil enhances left ventricular relaxation and diastolic filling in such patients. To investigate the association between changes in left ventricular filling and ...
Myers J - - 1985
Thirty patients who exhibited increased and 65 patients decreased spatial R wave amplitude during exercise testing were compared for left ventricular function and ischemic variables. Spatial R wave amplitude was derived from the three-dimensional Frank X, Y, Z leads using computerized methods. All patients had stable coronary artery disease and ...
Crisman R P - - 1985
Spontaneously hypertensive rats (SHR) were studied to test the hypothesis that endurance exercise training can stimulate capillary growth and offset the decrement associated with the development of myocardial hypertrophy. The exercise group (SHR-T) was trained on a treadmill for 10 weeks at 70-90% maximum VO2 and compared to nontrained SHR ...
Rose S P - - 1985
Day-old chicks peck when offered a bright bead; if the bead is coated with the bitter-tasting methylanthranilate (M) they avoid it thereafter. 2-[14C] Deoxyglucose injected 1 min prior to training shows increased uptake into the hyperstriatum ventrale (HV) and lobus parolfactorius (LPO) 30 min later compared with control birds which ...
Billman G E - - 1985
The hemodynamic response to submaximal exercise was investigated in 38 mongrel dogs with healed anterior wall myocardial infarctions. The dogs were chronically instrumented to measure heart rate (HR), left ventricular pressure (LVP), LVP rate of change, and coronary blood flow. A 2 min coronary occlusion was initiated during the last ...
Taylor N C - - 1985
Fourteen consecutive patients undergoing left ventricular aneurysmectomy and coronary artery bypass grafting were studied by multiple gated ventricular scintigraphy at rest and during exercise before and at six weeks and six months after surgery. All had congestive heart failure and 12 angina pectoris. Before operation left ventricular ejection fraction fell ...
Zucker I H - - 1985
Left atrial receptors with vagal afferents are reset and become less sensitive in dogs with chronic high output congestive heart failure (Zucker et al J Clin Invst 1977;60:323). We determined if the normal reflex inhibition of renal sympathetic nerve activity (RNA) which occurs in response to left atrial distension is ...
Anversa P - - 1985
The adaptation of the structural components in the myocardium of the left ventricle to strenuous exercise was studied morphometrically in rats following a treadmill running program. The response of the left ventricle was evaluated separately in the interventricular septum and in the left ventricular free wall. Exercise produced a 24% ...
Kirlin P C - - 1985
We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exercise. Resting hemodynamic parameters and exercise duration were not significantly altered by chronic ...
Huikuri H V - - 1985
The effect of coronary artery bypass grafting (CABG) on exercise-induced ventricular arrhythmias was examined in 53 patients. A bicycle exercise test and an isometric handgrip exercise test were performed before and 3 months after CABG. Exercise-induced ventricular arrhythmias were detected preoperatively in 14 patients (26%), in 13 during the bicycle ...
Fujii A M - - 1985
In this review some of the issues and controversies involved in the neural control of the myocardial inotropic response to stress have been discussed. For example, it is surprising that either direct or reflex activation of the sympathetic nerves induces a relatively small increase (20-40%) in the left ventricular inotropic ...
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