Obesity has long been considered a behavioral disorder. Recent breakthroughs in our understanding of body weight regulation, however, have shown that once adipose tissue accumulates, a system of overlapping neuroendocrine systems actively resists weight loss. This counter-regulatory mechanism, which has evolved as protection against starvation, causes changes in appetite and ...

BACKGROUND: Body mass index (BMI) is a risk factor for gastro-oesophageal reflux but may simply be explained by diet and lifestyle. AIM: We aimed to determine the contribution of BMI, diet and exercise to GER. METHODS: Community subjects (n = 211, mean age = 36 years, 43% males) completed validated ...

Seventeen women were divided into lean (19.5 +/- 0.5 years; 22.2 +/- 0.6 kg.m(-2)) and obese (20.4 +/- 0.5 years; 34.9 +/- 2.1 kg.m(-2)) groups. On completion of a submax cycle ergometer test and 10-repetition maximum (10RM) of 5 exercises on a Smith machine, subjects returned for 2 exercise sessions ...

PURPOSE: Aerobic capacity and respiratory function may be compromised in obesity, but few studies have been done in highly obese bariatric candidates. In a prospective study, these variables were documented in the preoperative period, aiming to define possible physiologic limitations in a apparently healthy and asymptomatic population. METHOD: Forty-six consecutively ...

OBJECTIVE: C-reactive protein (CRP), an obesity-related inflammatory marker, is a promising predictor for cardiovascular disease and may be a mediator for atherogenesis. It has been reported that diet-induced weight loss lowered CRP levels. However, the effect of exercise training, another therapy that can reduce weight, on CRP is still unclear. ...

Skeletal muscle from extremely obese individuals exhibits decreased lipid oxidation compared with muscle from lean controls. It is unknown whether this effect is observed in vivo or whether the phenotype is preserved after massive weight loss. The objective of this study was to compare free fatty acid (FFA) oxidation during ...

Physical activity is any movement of skeletal muscles that results in energy expenditure. Long-term success in weight management depends on both physical activity and dietary modification. Exercise has a pivotal role in weight management, optimising body composition by minimising fat-free mass losses and maximising fat mass loss; and, enhancing metabolic ...

Implications for Muscle Lipid Metabolism and An accumulation of intramuscular lipid has been reported with obesity and linked with insulin resistance. The purpose of this paper is to discuss: 1) mechanisms that may be responsible for intramuscular lipid accumulation with obesity, and 2) the effects of common interventions (weight loss ...

Ghrelin is directly involved with short-term regulation of energy balance. Although circulating levels of ghrelin are elevated in anorexia nervosa and reduced in obesity, the role of ghrelin in regulating long-term energy balance in healthy women has not been investigated. We examined the effects of a 3-month energy deficit-imposing diet ...

OBJECTIVE: To examine the prevalence of eating disturbances and psychiatric disorders among extremely obese patients before and after gastric bypass surgery and to examine the relationship between these disturbances and weight outcomes. RESEARCH METHODS AND PROCEDURES: Sixty-five women patients (ages 19 to 67) with a mean BMI of 54.1 were ...

OBJECTIVES: We sought to characterize the impact of obesity on vascular function in adolescents and to determine whether an exercise program reverses abnormalities in endothelial function. BACKGROUND: Obesity, a major modifiable risk factor for cardiovascular disease, is epidemic in Western societies, with rapid rates of increase in the young. Atherosclerosis ...

INTRODUCTION/PURPOSE: This study compared oxidative stress levels and antioxidant capacity in nonobese and obese participants after acute resistance (RX) and aerobic exercise (AX). METHODS: Blood samples were collected from 28 nonobese (mean = 20.8% body fat) and obese (mean = 35.0% body fat) participants pre- and immediately post-RX and AX. ...

OBJECTIVES: To determine the effects of equivalent diet- or exercise-induced weight loss and exercise without weight loss on subcutaneous fat, visceral fat, and insulin sensitivity in obese women. RESEARCH METHODS AND PROCEDURES: Fifty-four premenopausal women with abdominal obesity [waist circumference 110.1 +/- 5.8 cm (mean +/- SD)] (BMI 31.3 +/- ...

OBJECTIVES: Atherosclerosis is a disease that begins in childhood; endothelial dysfunction is its earliest detectable manifestation, and primary prevention strategies are likely to be most effective if instituted early. The aim of this study was to characterize the impact of obesity on vascular function in young children and to determine ...

OBJECTIVE: The Arthritis, Diet, and Activity Promotion Trial (ADAPT) was a randomized, single-blind clinical trial lasting 18 months that was designed to determine whether long-term exercise and dietary weight loss are more effective, either separately or in combination, than usual care in improving physical function, pain, and mobility in older ...

In classical antiquity, particularly in the Hippocratic Corpus, obesity was considered the cause of disease and, in the extreme, death. This attitude mirrors the general ideology of the times where any deviation from the norm and from logic was unacceptable. The image of balance and of the ideal body weight ...

BACKGROUND: Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality. OBJECTIVE: The intention of this study was to determine the independent and combined effects of diet-induced weight loss and exercise on markers of chronic inflammation. DESIGN: Three hundred sixteen community-dwelling, older (> or = 60 ...

The study examined associations among physical activity, cigarette smoking, body mass index, perceptions of body weight, weight-management goals, and weight-management behaviors of public high school adolescents. The CDC Youth Risk Behavior Survey provided a cross-sectional sample (n = 3,089) of public high school students in South Carolina. Logistic regression models ...

AIMS: To establish the relationship between exophthalmos and obesity. METHODS: A group of 19 obese patients (body mass index, BMI >/=30 kg/m(2)) was compared with a control group of 45 nonobese individuals (26 > BMI >/= 20 kg/m(2)). Both groups underwent Hertel's exophthalmometry, Goldmann applanation tonometry and measurement of the ...

PURPOSE: The purpose of this research was to evaluate attitudes toward obese individuals and to identify personal characteristics associated with antifat bias among students majoring in exercise science. METHODS: Undergraduate (N = 136) and graduate (N = 110) students (mean age 23.2 yr, 55% male, 77% Caucasian) completed a series ...

An evaluation was conducted to compare the impact of an 8-week cardiovascular disease risk reduction group teaching program for 92 individuals with mental retardation (MR; IQ less than 70) and 97 normal learners. The curriculum emphasized exercise, nutritional choices, and stress reduction. Body Mass Index (BMI; weight in kilograms, divided ...

OBJECTIVES: To investigate how obese adolescents think about themselves in terms of exercise, eating, and appearance and whether these cognitions change over the course of a residential weight loss camp. RESEARCH METHODS AND PROCEDURES: Obese adolescents [N = 61; age, 14.1 (+/-0.2) years; BMI, 33.9 (+/-0.7) kg/m(2)] completed assessments of ...

BACKGROUND: Obesity is a major health problem due, in part, to physical inactivity. The amount of activity needed to prevent weight gain is unknown. OBJECTIVE: To determine the effects of different amounts and intensities of exercise training. DESIGN: Randomized controlled trial (February 1999-July 2002). Setting and PARTICIPANTS: Sedentary, overweight men ...

Five major approaches namely dietary, exercise, behavior, combination and pharmacy therapies are used for treatment and control of obesity. In dietary therapy, low-calorie diet (LCD), which provides 800 to 1500 kcal of energy daily; a very-low-calorie diet (VLCD), which provides 250-800 kcal of energy daily and an energy-restricted or hypo ...

This paper describes the design, development and testing of an active area neutron dosemeter (AAND). The classic moderator and central detector is retained but in AAND this arrangement is augmented by small thermal neutron detectors positioned within the moderating body. The outputs from these detectors are combined using an appropriately ...

Prevention of the metabolic syndrome and treatment of its main characteristics are now considered of utmost importance in order to combat the epidemic of type 2 diabetes mellitus and to reduce the increased risk of cardiovascular disease and all-cause mortality. Insulin resistance/hyperinsulinaemia are consistently linked with a clustering of multiple ...

We examined the effects of weight loss induced by diet-orlistat (DO) and diet-orlistat combined with exercise (DOE) on maximal work rate production (Wmax) capacity in obese patients. Total of 24 obese patients were involved in this study. Twelve of them were subjected to DO therapy only and the remaining 12 ...

BACKGROUND: While the benefits of vigorous exercise on body weight and regional adiposity are well established, whether these benefits affect equally the highest and lowest portions of the weight distribution have not been previously reported. The impact of exercise on the more extreme body weights and body circumferences is clinically ...

Exercise is an important component of behavioral weight control interventions, and exercise may be most effective for weight control when combined with modifications to energy intake. Clinicians should initially encourage overweight and obese adults to adopt at least 150 minutes of moderate-intensity exercise per week (30 min x 5 d/wk), ...

Deciding to start a new diet and exercise plan can seem overwhelming if you try to change everything at once. By starting slowly and making gradual changes, you can build on your successes to reach your goals.

Exercise interventions are powerful tools for helping many patient populations. For those who need to manage their weight, an exercise program combined with diet modification may be key to losing weight and keeping it off. Many patients who are already at healthy weights find that physical activity helps to prevent ...

OBJECTIVE: To investigate the impact of 30-minute walking exercise at 70% VO2max on tissue plasminogen activator (t-PA) Ag and plasminogen activator inhibitor type 1 (PAI-1) Ag in obese sedentary males. RESEARCH METHODS AND PROCEDURES: A controlled observational study of the effect of a 30-minute acute exercise bout at 70% VO2max ...

OBJECTIVE: Weight gain is a frequent side effect of antipsychotic medication which has serious implications for a patient's health and well being. This study systematically reviews the literature on the effectiveness of interventions designed to control weight gain in schizophrenia. METHOD: A systematic search strategy was conducted of major databases ...

BACKGROUND: Prescription of aerobic exercise for obese subjects with mild hypertension in clinical practice remains to be investigated. METHODS: Forty-one Japanese obese males with hypertension were enrolled and compared with 41 age-and sex-matched obese subjects without hypertension and control subjects. In addition, 25 obese subjects with or without hypertension participated ...

OBJECTIVE: To investigate the effect of dietary restraint with or without exercise during weight maintenance after energy restriction. SUBJECTS AND METHODS: In total, 40 obese male subjects (mean BMI 32.3 kg/m(2); mean age 39 y) were recruited and randomly divided into a diet (D; n=20) and a diet plus exercise ...

BACKGROUND: Recommending increased physical activity facilitates long-term weight loss, but the optimal level of physical activity to recommend is unknown. OBJECTIVE: The objective of the study was to evaluate the efficacy for long-term weight loss of recommendations for much higher physical activity than those normally used in behavioral treatments. DESIGN: ...

BACKGROUND: Patients with severe obesity (body mass index (BMI) greater than 35 kg x m(-2)) present difficulties for end-tidal carbon dioxide (FE'(CO(2))) monitoring. Previous studies suggest that transcutaneous (TC) carbon dioxide measurements could be valuable, so we compared FE' and TC measures with Pa(CO(2)) in severely obese patients during anaesthesia. ...

CONTEXT: A higher duration and intensity of exercise may improve long-term weight loss. OBJECTIVE: To compare the effects of different durations and intensities of exercise on 12-month weight loss and cardiorespiratory fitness. DESIGN, SETTING, AND PARTICIPANTS: Randomized trial conducted from January 2000 through December 2001 involving 201 sedentary women (mean ...

BACKGROUND: Weight-shifting exercise was empirically practised in correcting the biased posture of people with stroke-induced hemiplegia. OBJECTIVES: (1) Evaluate the loading symmetry at the buttock-seat interface as a reflection of a postural defect in sitting. (2) Investigate if weight-shifting exercises could correct the postural problem of people with hemiplegia. DESIGN: ...

Although traditionally seen in middle aged and older people Type 2 diabetes, which is associated with obesity, poor diet and lack of exercise, is increasingly being diagnosed in children and young people who are overweight. Studies from around the world point to the usefulness of diet and exercise regimens in ...

BACKGROUND: Obesity is characterised by a marked insulin resistance which involves an abnormal regulation of K(+) uptake and metabolism. Less is known about the effect of physical exercise on K(+) kinetics. AIM OF THE STUDY: To assess plasma catecholamines and potassium levels and their relationship with cardiac activity during a ...

This study was performed retrospectively to investigate whether exercise energy expenditure (EE) measured during a standardized treadmill protocol (4.5 km/h at 0% grade) falls below predicted values after body weight loss in obese men. A reference equation was established to predict net exercise EE in a control sample of 83 ...

This study investigated the effects of short-term weight reduction on neutrophil functions in female judoists. Sixteen actively competing female judoists were divided into two groups. Eight who required weight reduction were defined as the weight reduction group, and the remaining eight were used as the control. Blood samples were taken ...

BACKGROUND: In light of the current obesity epidemic, treatment models are needed that can prevent weight gain or provide weight loss. We examined the long-term effects of a supervised program of moderate-intensity exercise on body weight and composition in previously sedentary, overweight and moderately obese men and women. We hypothesized ...

The aim of this study was to assess the effects on performance and work capacity of a short-term (3-week) integrated body weight reduction programme consisting of an energy-restricted diet, nutritional education, psychological counselling and aerobic exercise training at a constant metabolic load (5 days/week) in 71 severely obese patients (18 ...

10 undergraduate men were tested to determine the effects of lifting mode and frequency on psychophysically established maximum acceptable weight of lift for 4 hr. of work. The heart rate and rate of perceived exertion (RPE) of the individuals while lifting the maximum acceptable weight of lift were measured. When ...

AIM: Sources of motivation for intense physical exercise are poorly understood. Based on views that link such behaviour to preexisting psychopathology, we tested the hypotheses that history of childhood sexual abuse would be greater in intense exercisers than in non-exercisers, and that effects of abuse on self-esteem, perfectionism and body ...

Obesity is a chronic problem requiring lifelong treatment. Obesity assessment involves measurement of the body mass index, waist circumference, and the identification of other risk factors. Management should include diet and exercise. Selected patients can be offered pharmacotherapy, of which only sibutramine and orlistat are FDA-approved for long-term use. Bariatric ...

We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 +/- 1.4 yr, body mass index: 34.7 +/- 0.5 kg/m2) and a hypocaloric diet associated with exercise training (D + T, n = 25, age: 32.3 +/- 1.3 yr, body mass index: 32.9 +/- 0.4 kg/m2) ...

PURPOSE: Exercise training results in many health benefits, but few studies have focused on whether exercise training might attenuate the adverse effects of obesity on heart function. Therefore, the purpose of this study was to determine whether exercise training attenuated obesity-related decreases in systolic contractile function in response to beta-adrenergic ...