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Results 101 - 150 of 1078
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Masud Md Mehedi - - 2009
OBJECTIVE: Our aim was to evaluate changes in glucose metabolism of skeletal muscles and viscera induced by different workloads using (18)F-2-fluoro-2-deoxyglucose ([(18)F]FDG) and three-dimensional positron emission tomography (3-D PET). METHODS: Five male volunteers performed ergometer bicycle exercise for 40 min at 40% and 70% of the maximal O(2) consumption (VO(2max)). ...
Bweir Salameh - - 2009
BACKGROUND: The aim of this study was to compare the effects of 10 weeks of resistance or treadmill exercises on glycemic indices levels prior to and immediately following exercise in adults with type 2 diabetes. RESEARCH DESIGN AND METHOD: Twenty inactive subjects (mean age 53.5 years) with type 2 diabetes ...
Gjøvaag Terje F - - 2009
PURPOSE: There is an inverse relationship between insulin sensitivity and percentage of myosin heavy chain IIx (MyHC IIx) isoform in sedentary, obese, and type 2 diabetic humans. How different exercise conditions may reduce the proportion of MyHC IIx and in parallel elevate glucose transporter 4 (GLUT4) content is interesting in ...
Fernández Juan M - - 2009
The metabolic response when aerobic exercise is performed after the ingestion of glucose plus fructose is unclear. In the present study, we administered two beverages containing GluF (glucose+fructose) or Glu (glucose alone) in a randomized cross-over design to 20 healthy aerobically trained volunteers to compare the hormonal and lipid responses ...
Lanza Ian R - - 2009
Aging has been reported to be accompanied by reduced mitochondrial function and insulin sensitivity. Whether these deleterious effects result from chronological age or lifestyle-related factors such as adiposity and physical inactivity remains debatable. The beneficial effects of exercise on mitochondrial function and insulin sensitivity are well documented; however, it is ...
Dipietro Loretta - - 2008
BACKGROUND: Few studies have compared long-term moderate-intensity aerobic versus light-resistance training on serial improvements in glucose tolerance in older people. METHODS: Healthy, inactive older (74 +/- 5 [SD] years) women (N = 20) were randomized into either a high-volume, moderate-intensity aerobic (ATM, n = 12) or a lower-intensity resistance training ...
Dreyer Hans C - - 2008
Akt substrate of 160 kDa (AS160/TBC1D4) is associated with insulin and contraction-mediated glucose uptake. Human skeletal muscle AS160 phosphorylation is increased during aerobic exercise but not immediately following resistance exercise. It is not known whether AS160 phosphorylation is altered during recovery from resistance exercise. Therefore, we hypothesized that muscle AS160/TBC1D4 ...
Holtz Kaila A - - 2008
One bout of exercise enhances insulin-stimulated glucose uptake (insulin action), but the effect is blunted by consumption of carbohydrate-containing food after exercise. The independent roles of energy and carbohydrate in mediating post-exercise insulin action have not been systematically evaluated in humans. The purpose of this study was to determine if ...
Oguri Masato - - 2009
Hypoglycemia during exercise is a serious problem in diabetic patients during cardiac rehabilitation, whereas normal subjects rarely experience hypoglycemia. Inappropriate glucose uptake by working muscles may be responsible. However, the precise characteristics of glucose uptake during exercise have not been fully studied. We have investigated the effect of acute exercise ...
Gulve Eric Arthur - - 2008
Exercise, along with dietary intervention, represents first-line therapy for diabetes mellitus. Aerobic exercise is recommended for its beneficial effects on glucose control as well as its abilities to retard the progression of other comorbidities common in patients with diabetes, such as cardiovascular disease. The capability of aerobic exercise to improve ...
Turcotte Lorraine P - - 2008
The purpose of this review is to provide information about the role of exercise in the prevention of skeletal muscle insulin resistance, that is, the inability of insulin to properly cause glucose uptake into skeletal muscle. Insulin resistance is associated with high levels of stored lipids in skeletal muscle cells. ...
Harmer Alison R - - 2008
To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and without (control group) type 1 diabetes. Eight subjects with type 1 diabetes and seven control subjects, matched for age, BMI, and maximum oxygen uptake (Vo(2peak)), undertook 7 weeks of sprint training. Pretraining, subjects ...
Earnest Conrad P - - 2008
Current reports estimate that type II diabetes (T2D) affects 5-8% of adults. Also recognized is a transitional group of patients whose fasting blood glucose is abnormal; yet, not considered high enough to be diagnosed as diabetes. Defined as "pre-diabetes" these individuals have impaired fasting glucose (IFG; fasting glucose 100-125 mg/dL), ...
Bogaty Peter - - 2008
BACKGROUND: The aim of the study is to compare the impact of intravenous glucose versus lipid versus saline on exercise-induced myocardial ischemia in patients with stable angina. METHODS: Twelve men with coronary artery disease and positive exercise tests performed a symptom-limited, modified Bruce electrocardiogram (ECG) exercise test at 3 sessions, ...
Weiss Edward P - - 2008
Endothelial function deteriorates after glucose ingestion. This may be attributed to hyperglycemia-induced oxidative stress. Acute endurance exercise might improve postprandial endothelial function by enhancing glucoregulation and reducing postprandial hyperglycemia. The objective was to determine whether endurance exercise performed 17 h before high-sugar-food ingestion attenuates postprandial impairment in endothelial function. Healthy ...
Luebbers Paul E - - 2008
High-intensity (HI) resistance exercise augments postexercise glucose uptake to a greater degree than low-intensity (LO) resistance exercise; however, few studies have equated the work volumes between intensity levels. The purpose of this study was to compare the effect of acute HI and LO resistance exercise of equal work volume on ...
Moreira Sérgio R - - 2008
The purpose of this study was to compare different methods to identify the lactate threshold (LT) and glucose threshold (GT) on resistance exercise for individuals with type 2 diabetes. Nine men with type 2 diabetes (47.2 +/- 12.4 years, 87.6 +/- 20.0 kg, 174.9 +/- 5.9 cm, and 22.4 +/- ...
Numao Shigeharu - - 2008
INTRODUCTION: Few studies have reported the response of high-molecular-weight (HMW) adiponectin to acute aerobic exercise. PURPOSE: The purpose of this study was to investigate the influence of acute aerobic exercise on HMW adiponectin in healthy men. METHODS: Eight healthy men (age, 24.9 +/- 1.8 yr; BMI, 21.9 +/- 0.5 kg ...
Howarth Frank Christopher - - 2008
This study examined the influence of two intensities of exercise on ventricular myocyte shortening and intracellular calcium in the streptozotocin (STZ)-induced diabetic rat. Animals were divided into four groups: control sedentary (CS), diabetic sedentary (DS), diabetic light exercise (DLE; 5 x 30 min/week, 9 m/min) and diabetic moderate exercise (DME; ...
Zouhal Hassane - - 2009
After the age of 60, the decrease in physical activity and the increase in fat mass (FM) are two essential factors contributing to the alteration of glucose, insulin, and catecholamines responses induced by exercise. To discard these two factors, we compared the glucoregulatory responses in three different groups of men ...
Henderson Gregory C - - 2008
BACKGROUND: The regulation of glycemia is challenged in healthy men and women after exercise bouts of substantial energy expenditure. OBJECTIVE: We determined rates of glucose appearance (Ra), disappearance (Rd), and metabolic clearance (MCR) before, during, and after isoenergetic moderate and hard-intensity exercise. DESIGN: Ten men and 8 women received primed-continuous ...
Dietze Guenther J - - 2008
Recent evidence suggests a coordinated regulation by the local renin-angiotensin system (RAS) and tissue kallikrein-kinin system (TKKS) of blood flow and substrate supply in oxidative red myofibres of skeletal muscle tissue during endurance exercise. The performance of these myofibres is dependent on the increased oxidation of substrates facilitated by augmenting ...
- - 2008
Adiponectin, an adipokine secreted by the adipocyte, is inversely related to adiposity and directly related to insulin sensitivity. In type 1 diabetes mellitus (T1DM), however, data thus far are contradictory. We investigated the relationship between adiponectin and exercise inT1DM. Forty-nine children (14.5 +/- 2.0 yr, range 8-17 yr) with T1DM ...
Koshinaka Keiichi K Department of Health and Nutrition, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata City, Niigata 950-3198, - - 2008
A bout of prolonged aerobic exercise can enhance the sensitivity of muscle glucose uptake to insulin, and this may be mediated by activation of 5'-adenosine monophosphate-activated protein kinase (AMPK). The aim of this study was to examine whether high-intensity short-term exercise resulting in a significantly greater increase in the activation ...
Jenni S - - 2008
AIMS/HYPOTHESIS: We assessed systemic and local muscle fuel metabolism during aerobic exercise in patients with type 1 diabetes at euglycaemia and hyperglycaemia with identical insulin levels. METHODS: This was a single-blinded randomised crossover study at a university diabetes unit in Switzerland. We studied seven physically active men with type 1 ...
Lyerly G William GW Department of Exercise Science, University of South Carolina, Columbia, SC 29208, USA. - - 2008
An abnormal ECG during maximal exercise testing has been shown to be a powerful predictor of future coronary heart disease (CHD) mortality in asymptomatic men. However, little is known about the relationship between exercise ECG responses and CHD risk in men with diabetes mellitus. We examined the association between exercise ...
Hamrin K - - 2008
The present study investigated the changes occurring in interstitial metabolite concentrations and blood flow in insulin-resistant human skeletal muscle during the post-exercise recovery period following a single 2-h bout of one-legged exercise. In addition, the effect of microdialysis perfusion with insulin or the insulin-mimetic trace element vanadate was explored. Eight ...
Yang Ai-Lun - - 2008
Exercise is well-known in improving vascular functions, but the underlying mechanism has not been totally understood. The aim of this study was to examine whether single exercise session acutely enhances insulin-induced and insulin-like growth factor-1 (IGF-1)-induced vasorelaxation. Twenty-four male Wistar rats at age of 12 weeks were randomly divided into ...
Bordenave S - - 2008
AIM: The aim of this work was to quantify the magnitude of changes in insulin sensitivity (S(I)) and glucose effectiveness (S(G)) in response to acute exercise in type 2 diabetic (T2D) patients, as previously studied in non-diabetic subjects. METHODS: Seven T2D patients and seven non-diabetic controls participated in the study. ...
Liu X - - 2009
OBJECTIVES: To evaluate the feasibility, acceptability and effects of a Tai Chi and Qigong medical exercise programme that aimed to improve indicators of metabolic syndrome and glycaemic control in adults with raised blood glucose levels. Design, setting, and PARTICIPANTS: A single-group pre-post trial of 11 participants (3 men and 8 ...
Yeh S-H - - 2009
BACKGROUND: Exercise has been shown to be beneficial in the treatment of type 2 diabetes mellitus (DM); its benefit to immune function, however, remains to be determined. OBJECTIVE: This study investigated the effect of a 12-week course of Tai Chi Chuan (TCC) exercise on T cell helper (Th) reaction in ...
Lalande Sophie - - 2008
It is unclear whether impaired cardiac and/or vascular function contribute to exercise intolerance in patients with type 2 diabetes. PURPOSE: Magnetic resonance imaging (MRI) was used to determine whether reductions in cardiac output and/or femoral arterial blood flow contribute to reduced aerobic capacity in patients with type 2 diabetes. METHODS: ...
Lim Soo - - 2008
Exercise training enhances insulin sensitivity. Changes in retinol-binding protein-4 (RBP4) and adiponectin levels are linked to insulin resistance. We tested whether the insulin-sensitizing effect of exercise is associated with age-related changes in circulating RBP4 and adiponectin levels in women. We studied 36 healthy young (22.4 +/- 2.8 yr) and 38 ...
Cunha M R - - 2008
OBJECTIVES: To evaluate the effects of Metformin and Glyburide on cardiovascular, metabolic and hormonal parameters during progressive exercise performed to exhaustion in the post-prandial state in women with type 2 diabetes (T2DM). DESIGN AND METHODS: Ten T2DM patients treated with Metformin (M group), 10 with Glyburide (G group) and 10 ...
Nguyen Ngan Hien - - 2008
PURPOSE: Supervised exercise programs have been demonstrated to improve overall glycemic control but less well characterized is the evolution of glucose response to exercise during an exercise program. We addressed this issue, using an observational cohort design, among overweight adults with type 2 diabetes. We hypothesized that during the course ...
Salman F - - 2008
The essential therapy of diabetes mellitus includes medical nutrition therapy (MNT), exercise and medical therapy. Exercise, besides its metabolic effects, has positive influence on the immune system, but some forms of exercise may cause trauma for muscle and skeletal systems, they may also support negative effects on the immune system. ...
Schöndorf Thomas - - 2008
Pioglitazone is an established peroxisome proliferator-activated receptor gamma agonist for the treatment of insulin resistance in patients with type 2 diabetes mellitus. This analysis of the observational IRIS III study was performed to evaluate the effects of pioglitazone treatment in relation to the degree of physical exercise activities in a ...
Park S - - 2008
We investigated the effect and mechanism of exercise and chlorpromazine (CPZ), a conventional anti-psychotic drug, on beta-cell function and mass in 90% pancreatectomized (Px) male rats. The diabetic Px rats were divided into two groups, one of which was provided with exercise whereas the other was not. Both groups were ...
Adewole, S O; ;
Modern chronic diseases, including cardiovascular diseases, type 2 diabetes, metabolic syndromes, and cancer, are the leading killers in Westernized societies and are rampantly increasing in developing nations. Considerable amount of clinical and experimental evidence now exists suggesting that many biochemical pathways, strictly associated with diabetes, increase the production of reactive ...
Praet S F E - - 2008
OBJECTIVE: To determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy. DESIGN: Short-term, single-arm intervention trial. METHODS: Eleven male T2D patients (age: 59.1+/-7.5 years; body mass index: 32.2+/-4.0 kg/m2) performed ...
Francescato M P - - 2008
Recently, the relationship between percentage maximal heart rate vs. glucose oxidation rate has been proposed as a tool for estimating glucose oxidation rate during exercise in insulin-dependent diabetic patients. The reliability of this relationship and its applicability to long-term exercise is evaluated. Eight healthy volunteers performed a graded cycloergometric exercise ...
Stephens Francis B - - 2008
The aim of the present study was to determine the effect of post-exercise ingestion of a unique, high molecular weight glucose polymer solution, known to augment gastric emptying and post-exercise muscle glycogen re-synthesis, on performance during a subsequent bout of intense exercise. On three randomized visits, eight healthy men cycled ...
Praet S F E - - 2008
Regular exercise has been recommended for diabetes patients for many years; however, it is not widely used clinically. This may be because of high costs, lack of reimbursement, low compliance and/or absence of proper infrastructure. Alternatively, structured exercise therapy may be underutilised because current guidelines do not include detailed information ...
Abbas Yavari
Exercise can increase glucose uptake into skeletal muscle through an insulin-like effect. Mechanisms that control the homeostasis of glucose during muscle contracting, have not been known completely, but in the past several years significant progress about understanding of molecular basis of exercise effects has been provided. A central issue in ...
Mahapure Hemant
<b>Context:</b> Reactive oxygen species are known to aggravate disease progression. To counteract their harmful effects, the body produces various antioxidant enzymes, <i> viz</i> , superoxide dismutase, glutathione reductase etc. Literature reviews revealed that exercises help to enhance antioxidant enzyme systems; hence, yogic exercises may be useful to combat various diseases. ...
Mahapure Hemant
<b>Context</b> : Reactive oxygen species are known to aggravate disease progression. To counteract their harmful effects, the body produces various antioxidant enzymes, <i> viz</i> , superoxide dismutase, glutathione reductase etc. Literature reviews revealed that exercises help to enhance antioxidant enzyme systems; hence, yogic exercises may be useful to combat various ...
Banfi Giuseppe - - 2008
Regular exercise offers protection against all-cause mortality, primarily by protection against atherosclerosis and insulin resistance. There is evidence that physical training is effective as a treatment in patients with chronic heart diseases and type 2 diabetes. With excessive repetition of the training stimulus, local inflammation can generate a systemic inflammatory ...
Winnick Jason J - - 2008
OBJECTIVE: We aimed to identify whether racial differences in body composition and glucose metabolism occur in response to exercise and determine whether aerobic and resistance exercise modalities bring about differential changes in these parameters in African Americans and White persons with type 2 diabetes. RESEARCH DESIGN AND METHODS: Participants included ...
Hernández-Ordoñez M - - 2008
The purpose of this work is to present the main interactions promoted by exercise and synthesize them into mathematical equations. It is intended to extend the ability of the compartmental glucose-insulin model introduced by Sorensen [1985. A physiologic model of glucose metabolism in man and its use to design and ...
Moriyama Takahiro - - 2008
PURPOSE: Amino-acid (AA) infusions promote thermogenesis and prevent perioperative hypothermia, but the mechanism of action is unknown. We sought to verify the hypothesis that AA infusions stimulate the release of metabolic hormones during surgery and increase energy expenditure, resulting in thermogenesis. METHODS: Twenty-four patients were randomly assigned to receive AA ...
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