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Maor Elad E The Heart Centre, Chaim Sheba Medical Centre, Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Pinchas Borenstein Talpiot Medical Leadership Program, Chaim Sheba Medical Centre, Tel Hashomer, - - 2014
Heart failure with preserved ejection fraction can lead to pulmonary hypertension. The aim of the present study was to evaluate the role of exercise during right heart catheterization in the unmasking of diastolic dysfunction. Between 2004 and 2012, 200 symptomatic patients with exertional dyspnoea, preserved left ventricular systolic function and ...
Maltais François F Centre de Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Québec QC, G1V 4G5, Canada - - 2014
Exercise intolerance is a hallmark of chronic obstructive pulmonary disease (COPD). Patients with COPD were randomized in two multicentre, double-blind, incomplete block crossover studies. Patients received two of six treatments in sequence (12 weeks each): placebo, umeclidinium (UMEC)/vilanterol (VI) (125/25 mcg or 62.5/25 mcg), VI (25 mcg) or UMEC (62.5 ...
Emtner Margareta M Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University , Uppsala , - - 2014
Abstract Background. Weight loss and depletion of fat-free mass are common problems in patients with chronic obstructive pulmonary disease (COPD) and are related to muscular weakness and exercise intolerance. Physical training of COPD patients has good effect on exercise tolerance and quality of life. The aim of this study was ...
Niederseer David D Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University of Salzburg, Institute of Sports Medicine of the State of Salzburg, Sports Medicine of the Olympic Center Salzburg-Rif, Lindhofstr. 20, 5020, Salzburg, Austria, - - 2014
Evidence-based medicine promotes the current best evidence from clinical trials to guide decisions for individual patients. We assessed whether chronic obstructive pulmonary disease (COPD) patients included in exercise training studies and pharmacologic trials match those from a non-selected COPD target population sample. Exercise training studies were identified in a literature ...
Pellegrino Riccardo Giovanni RG Allergologia e Fisiopatologia Respiratoria - - 2014
Current guidelines recommend severity of chronic obstructive pulmonary disease be graded using forced expiratory volume in 1 s (FEV1). But this measurements is biased by thoracic gas compression depending on lung volume and airflow resistance. The aim of this study was to test the hypothesis that the effect of thoracic ...
Elbehairy Amany F - - 2014
Smokers with persistent cough and sputum production [chronic bronchitis (CB)] represent a distinct clinical phenotype, consistently linked to negative clinical outcomes. However, the mechanistic link between physiological impairment, dyspnea and exercise intolerance in CB has not been studied, particularly in those with mild airway obstruction. We therefore compared physiological abnormalities ...
Edsell Mark E ME Department of Anesthesia, St George's Healthcare NHS Trust, London, UK (Dr Edsell). Electronic address: - - 2014
Ascent to high altitude leads to a reduction in ambient pressure and a subsequent fall in available oxygen. The resulting hypoxia can lead to elevated pulmonary artery (PA) pressure, capillary stress, and an increase in interstitial fluid. This fluid can be assessed on lung ultrasound (LUS) by the presence of ...
Emerson Sam R SR Departments of 1Kinesiology and 2Human Nutrition, Kansas State University, Manhattan, - - 2014
We recently reported a high prevalence of expiratory flow limitation (EFL) independent of sex in prepubescent children that exceeds the prevalence reported in adults. It is unknown how trans-pubertal maturation and growth affect pulmonary function, specifically EFL, during exercise. The purpose of this longitudinal study was to investigate the changes ...
Silveira Leonardo L Postgraduate Program in Respiratory Sciences, Federal University of Rio Grande do Sul (UFRGS), Novo Hamburgo, - - 2014
Reduced fat-free mass (FFM), a common finding in chronic obstructive pulmonary disease (COPD), may indirectly impact peak exercise capacity through a greater level of pulmonary hyperinflation. We aimed to investigate if FFM index (FFM/squared height) impacts exercise induced dynamic hyperinflation in COPD patients. Fifty-four patients with moderate-to-very severe COPD performed ...
Rosato Edoardo E Department of Clinical Medicine, Clinical Immunology Unit-Scleroderma Centre, Sapienza University of Rome, Rome, Italy. - - 2014
In systemic sclerosis (SSc) patients pulmonary vasculopathy (PV) is present in the early stage of disease and impairs dilation of affected pulmonary blood vessels, impeding pulmonary blood flow during exercise. Abnormal gas exchange findings were early investigated by cardiopulmonary exercise test (CPET). A total of 34 female and 6 male ...
Hwangbo Pil-Neo PN Department of Rehabilitation Science Graduate School, Daegu University, Republic of - - 2014
[Purpose] The objective of this study was to determine the effect of thoracic joint mobilization and self-stretching exercise on the pulmonary functions of patients with chronic neck pain. [Subjects] The present study was performed with 34 patients with chronic neck pain featuring thoracic kyphosis; we divided them into a thoracic ...
Alison Jennifer A JA 1 Faculty of Health Sciences, The University of Sydney, NSW 2141, Australia ; 2 Physiotherapy Department, Royal Prince Alfred Hospital, NSW 2050, - - 2014
Pulmonary rehabilitation is an essential component of chronic obstructive pulmonary disease (COPD) management with strong evidence supporting the efficacy of pulmonary rehabilitation to improve exercise capacity and quality of life, as well as reduce hospital admissions. However, it is estimated that only 2-5% of people with COPD who could benefit ...
Caminiti Giuseppe G Department of Medical Sciences, Cardiovascular Research Unit, San Raffaele IRCCS, Rome, Italy (Dr Caminiti); Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Pisana, Rome, Italy (Dr Cardaci, Dr Conti, Dr Battaglia, Mr D'Antoni, and Dr Volterrani); and Dipartimento di Medicina Fisica e Riabilitazione, Università Tor Vergata, Rome, Italy (Mr - - 2014
To evaluate the impact of right ventricular dysfunction on exercise tolerance and potential changes resulting from exercise training in patients with chronic obstructive pulmonary disease (COPD) undergoing pulmonary rehabilitation. Subjects were 44 patients with a history of symptomatic (Global Initiative for Chronic Obstructive Lung Disease classes 2-4) COPD attending a ...
Neder J Alberto JA Respiratory Investigation Unit and Laboratory of Clinical Exercise Physiology, Queen's University and Kingston General Hospital, Kingston, ON, Canada Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Federal University of Sao Paulo, Sao Paulo, - - 2014
Ventilatory inefficiency during exercise is a key pathophysiological feature of chronic obstructive pulmonary disease. Currently, it is unknown how this physiological marker relates to clinically relevant outcomes as resting ventilatory impairment progresses across disease stages. Slope and intercept of the linear region of the ventilation-carbon dioxide output relationship and the ...
LeGear Tyler T Department of Physical Therapy/University of British Columbia, Canada. - - 2014
The chronic obstructive pulmonary disease (COPD) population can experience lower activity and fitness levels than the non-COPD population. The Nintendo Wii may be an appropriate at- home training device for the COPD population which could be used as a supplement for a pulmonary rehabilitation program. This study was a randomized, ...
Kern Lukas - - 2014
The 6-Minute Walk Test (6MWT) is representative of daily-life activities and reflects the functional capacity of patients. The change of oxygen uptake (VO2) in the initial phase of low-intensity exercise (VO2 kinetics) can be used to assess submaximal exercise performance of patients.The objective of the following study was to analyse ...
Vainshelboim Baruch B Pulmonary Institute (Messrs Vainshelboim and Fox, Ms Yehoshua, and Drs Fuks, Schneer, and Kramer), Department of Cardiothoracic Surgery (Dr Saute), and Echocardiography Unit, Department of Cardiology (Dr Sagie), Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel; and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (Drs Sagie and - - 2014
Pneumonectomy results in impairments of pulmonary function and exercise intolerance associated with respiratory limitations. However, exercise capacity and functional capacity are less known at long-term followup. The aims of this study were to assess exercise tolerance and functional capacity among long-term postpneumonectomy patients and to identify the limiting factors in ...
Vainshelboim Baruch B Pulmonary Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, - - 2014
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, interstitial lung disease, with few therapeutic options. IPF is characterized by pulmonary restriction, dyspnea, hypoxemia, exercise intolerance and poor quality of life (QOL). Objectives: We aimed to examine the effect of exercise training (ET) on clinical outcomes in IPF patients. Methods: ...
Casey Helen H Department of Cardiology, Musgrove Park Hospital, Taunton TA1 5DA, Somerset, - - 2014
Lesson Swimming-induced pulmonary oedema/edema (SIPO/SIPE) is likely to become commoner with increasing popularity of endurance sports meaning an increased awareness by participants, organisers and medical personnel is important, especially as individuals are at increased risk of future life threatening episodes and drowning if an accurate diagnosis and appropriate advice are ...
Andersen Mads J MJ Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN; Department of Cardiology, Aarhus University Hospital, Aarhus, - - 2014
-Invasive hemodynamic exercise testing is commonly used in the evaluation of patients with suspected heart failure with preserved ejection fraction (HFpEF) or pulmonary hypertension. Saline loading has been suggested as an alternative provocative maneuver, but the hemodynamic changes induced by the two stresses have not been compared. -Twenty-six subjects (aged ...
Nordvall Strömberg Petronella P Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University , Umeå , - - 2014
Abstract Purpose: The purpose of this study is to describe thoughts and attitudes of patients with chronic obstructive pulmonary disease (COPD) when talking about exercise training as treatment. Methods: Semi-structured interviews were performed and analyzed with the grounded theory method. Four men and six women were interviewed (ages 66-84 years), ...
Márquez-Martín Eduardo E Medical-Surgical Unit or Respiratory Diseases, Virgen del Rocío University Hospital, Spain; Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain. Electronic address: - - 2014
Non-invasive ventilation and exercise training might prove beneficial in the management of COPD patients. to compare the combined use of exercise training and non-invasive ventilation with the two interventions separately in chronic respiratory failure due to chronic obstructive pulmonary disease. As primary objective exercise capacity and secondary objectives gas exchange, ...
Gielen Stephan S Martin-Luther-University Halle/Wittenberg, University Hospital, Dept. of Int. Medicine III, Halle/Saale, Germany. Electronic address: - - 2014
Over the last decades exercise training has evolved into an established evidence-based therapeutic strategy with prognostic benefits in many cardiovascular diseases (CVDs): In stable coronary artery disease (CAD) exercise training attenuates disease progression by beneficially influencing cardiac risk factors (i.e., hyperlipidemia, hypertension) and coronary endothelial function. In heart failure (HF) ...
Marra A M AM Pulmonary Hypertension Unit, Thoraxclinic, University Hospital Heidelberg, Heidelberg, Germany; Department of Translational Medical Sciences, "Federico II" University School of Medicine, Naples, - - 2014
Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). The main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch, and weakness of skeletal and breathing muscles. The aim of the current review is to describe the findings in the existing literature about ...
Jolley Caroline J CJ King's College London Division of Asthma, Allergy and Lung Biology, King's College London School of Medicine, King's Health Partners, London, UK - - 2014
The aim of this study was to test the hypothesis that neural respiratory drive, measured using diaphragm electromyogram (EMGdi) activity expressed as a percentage of maximum (EMGdi%max), is closely related to breathlessness in chronic obstructive pulmonary disease. We also investigated whether neuroventilatory uncoupling contributes significantly to breathlessness intensity over an ...
Leung Nelson N Division of Nephrology and Hypertension; Division of - - 2014
A 74-year-old white male, lifetime non-smoker underwent evaluation for a three year history of dyspnea. Patient was a former professional athlete who was still working full time. He had remained physically fit and was able to perform his regular exercise routine which included 25 minutes on the elliptical machine plus ...
Dowman Leona L Department of Physiotherapy, La Trobe University, Melbourne, Australia, - - 2014
Interstitial lung disease (ILD) is characterised by reduced functional capacity, dyspnoea and exercise-induced hypoxia. Pulmonary rehabilitation, an intervention that includes exercise training, is beneficial for people with other chronic lung conditions; however its effects in ILD have not been well characterised. • To determine whether pulmonary rehabilitation in patients with ...
Tanaka Takako T Department of Cardiopulmonary Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, - - 2014
[Purpose] To examine the long-term effects of air pollution on the physical functioning of a group of officially acknowledged victims of pollution-related illnesses (Victims group) who were exposed to air pollution more than 50 years ago, we compared them with age-matched patients with chronic obstructive pulmonary disease (COPD group). [Subjects and ...
Seo KyoChul K Department of Physical Therapy, Korea Nazarene University, Republic of - - 2014
[Purpose] The purpose of this study was to determine whether proprioceptive neuromuscular facilitation (PNF) respiration exercise increases the pulmonary function of normal adults. [Subjects and Methods] Twenty-eight normal adults in their 20s were randomly assigned to an experimental group (n=14) or control group (n=14). Over the course of four weeks, ...
Pradella Cristiane O CO Pulmonary Rehabilitation Center, - - 2014
The aim of this study was to develop an efficient, low-cost, home-based pulmonary rehabilitation program and to evaluate the impact of the program on exercise as measured by the 6-min walk test (6MWT) and treadmill endurance test. Twenty-nine subjects with COPD (FEV1 = 62.4 ± 10.7% of predicted, 62.4 ± ...
Vernillo G G Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; CeRiSM, Research Center "Sport, Mountain and Health", University of Verona, Rovereto, - - 2014
This study aimed to assess the effects of an extreme mountain ultramarathon (MUM, 330 km, 24 000 D+) on lung function. Twenty-nine experienced male ultramarathon runners performed longitudinally [before (pre), during (mid), and immediately after (post) a MUM] a battery of pulmonary function tests. The tests included measurements of forced vital capacity, ...
Hassel Erlend - - 2014
BackgroundRight ventricular dysfunction in COPD is common, even in the absence of pulmonary hypertension. The aim of the present study was to examine the effects of high intensity interval training (HIIT) on right ventricular (RV) function, as well as pulmonary blood vessel remodeling in a mouse model of COPD.Methods42 female ...
Wibmer Thomas T Department of Internal Medicine II, University Hospital of Ulm, Ulm, Germany. - - 2014
There is growing evidence that exercise-induced variation in lung volumes is an important source of ventilatory limitation and is linked to exercise intolerance in COPD. The aim of this study was to compare the correlations of walk distance and lung volumes measured before and after a 6-min walk test (6MWT) ...
Neder J Alberto JA 1Respiratory Investigation Unit, Queen's University & Kingston General Hospital , Kingston, Ontario , - - 2014
Abstract The difference between total lung capacity (TLC) by body plethysmography and alveolar volume (VA) from the single-breath lung diffusing capacity measurement provides an index of ventilation distribution inequalities in COPD. The relevance of these abnormalities to dyspnea and exercise intolerance across the continuum of disease severity remains unknown. Two-hundred ...
Fuschillo Salvatore S Pulmonary Rehabilitation Unit - - 2014
Patients with kyphoscoliosis and severe respiratory impairment frequently experience reduction in exercise tolerance, limitation in daily life activities, and deterioration in health-related quality of life (HRQOL). Noninvasive ventilation (NIV) as an add-on treatment to long-term oxygen therapy (LTOT) was shown to improve symptoms and HRQOL in these patients. Pulmonary rehabilitation ...
van Gestel Arnoldus J R AJ Department of Pulmonary Medicine, Cantonal Hospital, St. Gallen, - - 2014
Background: The 6-min walk test (6MWT) is representative of daily life activities and reflects the functional capacity of patients with chronic obstructive pulmonary disease (COPD). Information on the cardiopulmonary and gas exchange responses to the 6MWT is limited. Objectives: We aimed to analyze the breath-by-breath cardiopulmonary and gas exchange responses ...
López-García A A Department of Physiotherapy, Faculty of Physiotherapy, University of A Coruña (UDC), Spain - - - 2014
Muscular training is the corner stone of pulmonary rehabilitation programs. To evaluate the effects of a muscular training program -- carried out on COPD subjects with antecedents of moderate or severe exacerbation -- on exercise tolerance, Health Related Quality of Life (HRQoL) and illness prognosis. A quasi--experimental study. University Hospital ...
Inagaki Takeshi T Department of Respirology, Graduate School of Medicine, Chiba University, Japan; Division of Rehabilitation, Chiba University Hospital, Japan. Electronic address: - - 2014
Management of chronic thromboembolic pulmonary hypertension (CTEPH) has recently improved because of advances in pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA), and disease-targeted medications. However, patients with inoperable CTEPH or persistent pulmonary hypertension (PH) after these interventions continue to exhibit impaired exercise capacity and limited quality of life (QOL). Eight ...
O'Donnell Denis E DE Queen's University and Kingston General Hospital, Kingston, Ontario, Canada;1Queen's University and Kingston General Hospital, Kingston, Ontario, Canada. - - 2014
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and, although it is a preventable and treatable disease, it often remains undiagnosed in patients with mild disease. It is now evident that pathologic changes and physiologic impairment start early in disease progression, and even patients ...
Yeh Gloria Y - - 2014
Chronic obstructive pulmonary disease (COPD) is a chronic, progressively debilitating condition that is prevalent in the US and worldwide. Patients suffer from progressive dyspnea and exercise intolerance. Physical exercise is beneficial, but conventional pulmonary rehabilitation programs are underutilized. There remains a need for novel interventions that improve symptoms, quality-of-life, and ...
Guenette Jordan A JA Respiratory Investigation Unit, Queen's University and Kingston General Hospital, Kingston, ON, Canada Dept of Physical Therapy, University of British Columbia, Vancouver, BC, Canada Centre for Heart Lung Innovation, Providence Health Care Research Institute, University of British Columbia, St. Paul's Hospital, Vancouver, BC, - - 2014
The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative sensory consequences. Subjects meeting spirometric criteria for mild COPD ...
Ho Jen-Yu JY a Department of Athletic Performance , National Taiwan Normal University , Taipei , - - 2014
This study examined hormonal responses to low-intensity resistance exercise under mild simulated hypoxia. Ten resistance untrained men performed five sets of 15 repetitions of squat exercise at 30% of 1RM under normobaric hypoxia (FiO2 = 15%) and normoxia in a cross-over and counter-balanced design. Blood lactate (LAC), growth hormone (GH), ...
Eliakim A A 1Child Health & Sports Center, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel. 2The Zinman College of Physical Education and Sport Sciences, Wingate Institute, Netanya, - - 2014
Exercise-associated effects on the GH→IGF-I axis were studied, mainly following aerobic exercise. We determined the gender effect on the GH→IGF-I axis response to a standard all-out Wingate anaerobic test (WAnT) in healthy active young adult males and females (males=12, females=16, age range: 24-34 years). Blood samples for GH and IGF-I, ...
JanukonytÄ— J J Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark. Electronic address: - - 2014
Diurnal variation in serum growth hormone (s-GH) levels after exogenous GH delivery has previously been reported in patients with no endogenous GH secretion. Changes in postural position or physical activity, leading to changes in blood flow and/or lymphatic drainage may be underlying explanations. The primary aim of this study is ...
Moeller Chad R CR Arizona Diamondbacks Baseball Club, - - 2014
Context :  Alterations in scapular muscle activation, which are common with glenohumeral (GH) injuries, affect stability and function. Rehabilitation aims to reestablish activation between muscles for stability by progressing to whole-body movements. Objective :  To determine scapular muscle-activation ratios and individual muscle activity (upper trapezius [UT], middle trapezius [MT], lower ...
Voss Sven Christian SC Anti-Doping Lab Qatar, PO Box 27775, Doha, Aspire Zone, Doha, - - 2014
The major objective of this study was to investigate the effects of several days of intense exercise on the growth hormone marker approach to detect doping with human growth hormone (hGH). In addition we investigated the effect of changes in plasma volume on the test. Fifteen male athletes performed a ...
Andrews Leanne L School of Health and Human Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. Electronic address: - - 2014
To investigate changes and differences in patient outcomes over time for 6, 7 and 8 week pulmonary rehabilitation programmes in order to identify optimal duration. Community based pulmonary rehabilitation programmes in the East of England. In total 363 participants completed one of the three pulmonary rehabilitation programmes. Patients with a ...
Budnar Ronald G RG Jr 1Applied Physiology Laboratory Department of Kinesiology, Health Promotion and Recreation University of North Texas Denton, TX 76203 2Department of Biological Sciences University of North Texas Denton, TX - - 2014
The purpose of this investigation was to examine the acute hormonal response to the kettlebell swing exercise. Ten recreationally resistance trained men (24±4 y, 175±6 cm, 78.7±9.9 kg) performed 12 rounds of 30 seconds of 16 kg kettlebell swings alternated with 30 seconds of rest. Blood samples were collected before ...
Rezaee S S Department of Physiotherapy Tarbiat Modares University, Tehran, Iran - - - 2014
Aim: This study investigated the influence of resistance (R) following endurance (E) exercise or ER on acute hormonal responses, such as growth hormone (GH), total testosterone (TT), free testosterone (FT), IGF-1, and cortisol. Methods: Ten healthy young men with an average age of 23.9 years (±0.7 y), a height of ...
Ackerman James - - 2014
Antioxidant supplementation is known to increase human endogenous antioxidant (AOX) capacity providing a means of blunting exercise induced reactive oxygen species (ROS). The purpose of this study was to compare the effects of a single acute dose of an AOX (vs blinded placebo) on muscle contractile performance and hormonal responses ...
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