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Yamanaka Yujiro Y Hokkaido - - 2014
Our previous study demonstrated that physical exercise under dim lights (<10 lux) accelerated re-entrainment of the sleep-wake cycle but not the circadian melatonin rhythm to an 8 h phase-advanced sleep schedule, indicating differential effects of physical exercise on the human circadian system. The present study examined the effects of bright ...
Anastasilakis Athanasios D AD Department of Endocrinology, 424 General Military Hospital, Thessaloniki, - - 2014
Context: The myokine irisin may increase energy expenditure and affect metabolism. Objective: To elucidate predictors of irisin and study whether circulating irisin may have day-night rhythm in humans. Design: Observational, cross-sectional study with an additional 24h prospective observational arm (Day-night rhythm sub-study) and two prospective interventional arms (Mixed meal sub-study ...
Thrift Aaron P AP Public Health Sciences, Fred Hutchinson Cancer Research - - 2014
Background: The inverse association between physical activity and cancer risk may be mediated by higher melatonin levels. However, few studies have examined the effect of increased physical activity on melatonin levels. Methods: The parent study was a randomized controlled trial (RCT) which randomized 51 men and 49 women to a ...
Hong Yunkyung Y Department of Rehabilitation Science, Graduate School of Inje University, Gimhae, Korea; Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University, Gimhae, Korea; Ubiquitous Healthcare Research Center, Inje University, Gimhae, - - 2014
Osteoarthritis (OA) is a major cause of disability in the adult population. The purpose of this study was to evaluate the effects of melatonin with graded dosage on extracellular matrix synthesis and cellular death in response to cartilage damage in vitro and in vivo. TNF-α reduced the viability of primary ...
Murphy B A BA School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: - - 2014
Circadian rhythms are endogenously generated 24-h oscillations that coordinate numerous aspects of mammalian physiology, metabolism and behaviour. The existence of a molecular circadian clock in equine skeletal muscle has previously been demonstrated. This study investigates how the circadian 24-h expression of exercise-relevant genes in skeletal muscle is influenced by a ...
Kraemer William J WJ 1Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269 USA 2Department of Biology of Physical Activity, University of Jyväskylä, University of Jyväskylä, Finland 3School of Biomedical and Sports Science, Edith Cowan University, Joondalup, WA, Australia 4Department of Kinesiology, Health Promotion and Recreation, University of North Texas, Denton, TX 76203 5Department of Kinesiology, University of Rhode Island, Kingston, RI 02881 6Institute of Exercise Physiology and Wellness, Department of Educational and Human Sciences University of Central Florida Orlando, FL - - 2014
Time of day as when to train has become an important question for many strength and conditioning specialists and this study was designed to add some insights into this complex question. The primary purpose of this investigation was to examine physical performance within the temporal context of melatonin and catecholamine ...
Lee Youngjeon Y Department of Rehabilitation Science, Graduate School of Inje University, 197 Inje-ro, Gimhae, Gyeong-nam 621-749, Korea. - - 2014
Endogenous neural stem/progenitor cells (eNSPCs) proliferate and differentiate into neurons and glial cells after spinal cord injury (SCI). We have previously shown that melatonin (MT) plus exercise (Ex) had a synergistic effect on functional recovery after SCI. Thus, we hypothesized that combined therapy including melatonin and exercise might exert a ...
Kirshenbaum Greer S GS Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Electronic address: - - 2013
Bipolar disorder is a neuropsychiatric disease characterized by states of mania with or without depression. Pharmacological treatments can be inadequate at regulating mood for many individuals. Melatonin therapy and aerobic exercise are independent prospective therapies for bipolar disorder that have shown potential as mood stabilizers in humans. Myshkin mice (Myk/+) ...
Hong Yunkyung - - 2013
The purpose of this study was to determine the effects of melatonin intervention on gastrocnemius remodeling in rats with collagenase-induced knee instability. Type VII collagenase was injected into the right knee to induce joint laxity with cartilage destruction. Melatonin (MT; 10 mg/kg) injection was performed twice daily subcutaneously, and treadmill ...
Cuesta Marc - - 2013
Progressive disruption of circadian rhythmicity associated with disturbance of the sleep-wake cycle is one of the most insidious symptoms of Huntington's disease (HD) and represents a critical management issue for both patients and their care takers. The R6/2 mouse model of HD shows a progressive disruption of the circadian rhythmicity ...
Khaleghipour Shahnaz S Department of Psychology, Naein Branch, Islamic Azad University, Naein, IR - - 2013
The nocturnal enuresis is one of the most common complaints of childhood. Upper airway obstruction and nocturnal snoring affect the nocturnal enuresis in children. The aim of this study was to investigate the effects of breathing exercises on the nocturnal enuresis in the children with the sleep-disordered breathing. This study ...
Fonken Laura K - - 2013
Most organisms display circadian rhythms that coordinate complex physiological and behavioral processes to optimize energy acquisition, storage, and expenditure. Disruptions to the circadian system with environmental manipulations such as nighttime light exposure alter metabolic energy homeostasis. Exercise is known to strengthen circadian rhythms and to prevent weight gain. Therefore, we ...
Beck W - - 2013
The aims of this study were: a) to analyze the time of day effect on the aerobic capacity and time to exhaustion at aerobic capacity intensity (TE), and b) to analyze the physiological impact of handling and exercise testing during the light and dark periods, based on hematological parameters. Eighty ...
Yamada Minoru - - 2013
To investigate the effects of a twice-weekly multitarget stepping (MTS) task combined with a multicomponent exercise program on stepping accuracy, gaze behavior, fall risk factors, and fall rates. Randomized controlled trial. Community. Community-dwelling adults aged 65 and older in Japan (N = 264) were randomized into an MTS group (n = 132) and a ...
Rakshit Kuntol - - 2013
Daily life functions such as sleep and feeding oscillate with circa 24 h period due to endogenous circadian rhythms generated by circadian clocks. Genetic or environmental disruption of circadian rhythms is associated with various aging-related phenotypes. Circadian rhythms decay during normal aging, and there is a need to explore strategies ...
Arikawa Andrea Y - - 2013
Background:Women with breast cancer have decreased levels of melatonin or its metabolite in plasma and/or urine. Methods:We measured serum melatonin, urinary 6-sulfatoxymelatonin, catecholamines and cortisol in 141 sedentary young female participants in a clinical trial comparing 150 min/wk aerobic exercise for 4 months to no-exercise controls. Demographics, health surveys, body ...
Mendes Caroline - - 2013
The pineal gland, through melatonin, seems to be of fundamental importance in determining the metabolic adaptations of adipose and muscle tissues to physical training. Evidence shows that pinealectomized animals fail to develop adaptive metabolic changes in response to aerobic exercise and therefore do not exhibit the same performance as control-trained ...
Bernhardt Vipa V Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, TX 75231, - - 2013
Obesity affects lung function and gas exchange and imposes mechanical ventilatory limitations during exercise that could disrupt the predictability of Pa(CO(2)) from end-tidal P(CO(2)) (P(ETCO(2))), an important clinical tool for assessing gas exchange efficiency during exercise testing. Pa(CO(2)) has been estimated during exercise with good accuracy in normal-weight individuals by ...
Makey Kristina L KL Cancer Institute, and Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, - - 2013
The incidence of breast cancer is increasing worldwide, and this seems to be related to an increase in lifestyle risk factors, including physical inactivity and overweight/obesity. We have reported previously that exercise induced a circulating angiostatic phenotype characterized by increased soluble fms-like tyrosine kinase-1 (sFlt-1) and endostatin and decreased unbound ...
Ackerman Kathryn E KE Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, - - 2013
Amenorrhoea and low bone density are common in excessive exercisers, yet endocrine factors that differentiate adolescent amenorrhoeic exercisers (AE) from eumenorrhoeic exercisers (EE) are unclear. We have previously reported that high ghrelin and low leptin predict lower LH secretion in AE. Leptin and ghrelin impact cortisol secretion, and hypercortisolaemia can ...
Huang Yuh-Chin T - - 2012
Context: Exposure to single pollutants e.g. particulate matter (PM) is associated with adverse health effects, but it does not represent a real world scenario that usually involves multiple pollutants. Objectives: Determine if simultaneous exposure to PM and NO(2) results in synergistic interactions. Materials and methods: Healthy young volunteers were exposed ...
Grøntved Anders - - 2012
BACKGROUND The role of weight training in the primary prevention of type 2 diabetes mellitus (T2DM) is largely unknown. METHODS To examine the association of weight training with risk of T2DM in US men and to assess the influence of combining weight training and aerobic exercise, we performed a prospective ...
Williams Paul T - - 2012
Physical activity recommendations are defined in terms of time spent being physically active (e.g., 30 min of brisk walking, 5 d · wk(-1)). However, walking volume may be more naturally assessed by distance than by time. Analyses were therefore performed to test whether time or distance provides the best metric ...
Felip O - - 2012
To determine the effects of sustained swimming on the use and fate of dietary nutrients in gilthead sea bream, a group of fish were forced to undertake moderate and sustained swimming (1.5 BL s(-1)) for 3 weeks and compared with a control group undertaking voluntary activity. The exercise group showed a significant increase ...
Melsom Toralf - - 2012
Abnormally elevated GFR, or hyperfiltration, is a proposed mechanism for kidney injury in diabetes, prediabetes, and obesity. This study investigated whether lack of physical exercise is associated with hyperfiltration and whether exercise modifies the positive association between fasting glucose and measured GFR. The Renal Iohexol Clearance Survey in Tromsø 6 ...
Potter C R - - 2012
Objective:To compare the phase II oxygen uptake time constant (τV'O(2)) and V'O(2) mean response time (V'O(2)MRT) in overweight (OW) and non-OW (NO) children during moderate intensity exercise.Design:Between subjects where participants completed a maximal ramp exercise test on an electromagnetically braked cycle ergometer to determine peak V'O(2) (V'O(2peak)) and gas exchange ...
Aoi Wataru - - 2012
PURPOSE: The effect of exercise performed on the day of meal intake on postprandial triglyceride concentration, which is an independent risk factor for cardiovascular disease, is unclear. The present study investigated the effects of combined low-intensity exercise before and after a high-fat meal on serum triglyceride concentrations. METHODS: Ten healthy ...
Kanaley Jill A JA Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA. - - 2012
Women with type 2 diabetes (T2D) show greater rates of mortality due to ischemic heart disease than men with T2D. We aimed to examine cardiovascular and autonomic function responses to isometric handgrip (IHG) exercise between men and women with T2D, before and after an exercise training program. Hemodynamic responses were ...
Lee Man-Gyoon - - 2012
The primary purpose of this study was to investigate the effects of high-intensity exercise training under relatively equal energy expenditure on whole body fat and abdominal fat loss, and cardiorespiratory fitness. Twenty-two untrained middle-aged Korean females were randomized into one of the following groups: control, low-intensity training group (LI), and ...
Mason Caitlin C Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, - - 2013
Given that the repetitive loss and regain of body weight, termed weight cycling, is a prevalent phenomenon that has been associated with negative physiological and psychological outcomes, the purpose of this study was to investigate weight change and physiological outcomes in women with a lifetime history of weight cycling enrolled ...
Cintra Dennys E - - 2012
AIM: The dysregulation of regulatory element-binding protein-1c (SREBP-1c) is associated with hepatic steatosis. However, effects of exercise on SREBP-1c protein level in liver have not been investigated. Thus, in this study we investigated if reversion of the hepatic steatosis-induced by exercise training is related with levels of SREBP-1c. MAIN METHODS: ...
Siebel Andrew L - - 2012
Being born pre-term and/or small for gestational age are well-established risk factors for cardiometabolic disease in adulthood. Physical activity has the potential to mitigate against the detrimental cardiometabolic effects of low birth weight from two perspectives: a) maternal exercise prior to and during pregnancy and b) exercise during childhood or ...
Fritz T - - 2012
The effects of Nordic walking on cardiovascular risk factors were determined in overweight individuals with normal or disturbed glucose regulation. We included 213 individuals, aged 60 ± 5.3 years, with BMI 30.2 ± 3.8 kg/m(2) ; of these 128 had normal glucose tolerance (NGT), 35 had impaired glucose tolerance (IGT), and 50 had type 2 diabetes ...
Phillips Melody D - - 2012
PURPOSE: Aerobic exercise is frequently prescribed to reduce inflammatory-related disease (CVD, diabetes) risk. Resistance training (RT), however, may be key to maximizing antiinflammatory benefits of consistent exercise. We examined the influence of RT on inflammatory biomarkers in obese, postmenopausal women. METHODS: Twenty-three women (65.6±2.6 yr; BMI: 33 kg[BULLET OPERATOR]m) underwent ...
Mendelson Monique - - 2012
The aim of this study was to examine ventilatory responses to training in obese adolescents. We assessed body composition, pulmonary function and ventilatory responses (among which expiratory flow limitation and operational lung volumes) during progressive cycling exercise in 16 obese adolescents (OB) before and after 12 weeks of exercise training ...
Pazin Nemanja N Faculty of Sports and Physical Education, The Research Center, University of Belgrade, Belgrade, - - 2013
The previously proposed maximum dynamic output hypothesis (MDO: i.e. the optimum load for maximizing the power output during jumping is one's own body) was tested on individuals of various activity profiles. Forty males (10 strength-trained athletes, 10 speed-trained athletes, 10 physically active non-athletes, and 10 sedentary individuals) performed different vertical ...
Machado Eduardo Coelho - - 2012
This paper concerns a cross-sectional population-based study conducted with adults living in the city of Pelotas, Rio Grande do Sul State, Brazil. It aims to determine the prevalence of weight-loss practices and use of substances for weight-loss during the 12 months preceding the interview. The prevalence of weight-loss attempts was ...
Rosenkilde Mads - - 2012
The amount of weight loss induced by exercise is often disappointing. A diet-induced negative energy balance triggers compensatory mechanisms, e.g. lower metabolic rate and increased appetite. However, knowledge about potential compensatory mechanisms triggered by increased aerobic exercise is limited. A randomized controlled trial was performed in healthy sedentary moderately overweight ...
Yeo N H - - 2012
Myokines and angiogenesis factors, studies on trainings according to the difference of exercise intensity are not sufficient, and it has not been elucidated. Particularly, studies on the effect of resistance exercise according to the intensity of resistance exercise on blood myokines and angiogenesis may be essential in the metabolic process ...
Ng J Y Y - - 2012
We examined motivation contagion in a hypothetical exercise setting. Exercise science students (n = 164) were provided with quotes of hypothetical male and female obese exercisers displaying different quality of motivation to start an exercise program. We used a 3 (exerciser motivation) × 2 (exerciser gender) × 2 (student gender) ...
Wagener A - - 2012
In a mouse model for juvenile obesity, we investigated how the age of onset of voluntary exercise affects factors of the metabolic syndrome. One exercise group had access to running wheels from 3 weeks (representing childhood) and another one from 9 weeks on (early adulthood). Both groups were compared to ...
Gremeaux Vincent - - 2012
OBJECTIVE: The aim of this study was to study the impact of a combined long-term lifestyle and high-intensity interval training intervention on body composition, cardiometabolic risk, and exercise tolerance in overweight and obese subjects. DESIGN: Sixty-two overweight and obese subjects (53.3 ± 9.7 yrs; mean body mass index, 35.8 ± ...
Barrett-O'Keefe Zachary - - 2012
A sustained post-exercise vasodilatation which is histamine-receptor mediated has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistance exercise could provide novel insight into the pathways responsible for histamine-receptor ...
Roudier Emilie - - 2012
Exercise-induced angiogenesis is a key determinant of skeletal muscle function. Here, we investigated whether the E3 ubiquitin ligase murine double minute-2 (Mdm2) exerts a proangiogenic function in exercised skeletal muscle. Mdm2 hypomorphic (Mdm2(Puro/Δ7-9)) mice have a 60% reduction in Mdm2 expression compared with that in wild-type animals. Capillary staining on ...
García-Benítez Sergio - - 2012
Owing to the risk of severe rhabdomyolysis, clinicians advise McArdle disease patients to refrain from strenuous exercise, particularly weight lifting. A 15-year-old male McArdle disease patient performed a 6-week, supervised, light- to moderate-intensity (∼65-70% of one-repetition-maximum) resistance (weight lifting) training program (2 sessions/week). Training resulted in ∼27% and ∼6% increase ...
Di Thommazo-Luporini Luciana - - 2012
BACKGROUND: Impaired exercise tolerance is directly linked to decreased functional capacity as a consequence of obesity. OBJECTIVES: To analyze and compare the cardiopulmonary, metabolic, and perceptual responses during a cardiopulmonary exercise test (CPX) and a treadmill six-minute walking test (tread6MWT) in obese and eutrophic women. METHOD: Twenty-nine female participants, aged ...
Chenevière Xavier - - 2012
This study aimed to compare the effects of 2 different prior endurance exercises on subsequent whole-body fat oxidation kinetics. Fifteen men performed 2 identical submaximal incremental tests (Incr2) on a cycle ergometer after (i) a ∼40-min submaximal incremental test (Incr1) followed by a 90-min continuous exercise performed at 50% of maximal ...
Gao Zhaohui Z Penn State Hershey Heart and Vascular Institute, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, - - 2013
Obesity is a disease of oxidative stress (OS). Acute hyperoxia (breathing 100 % O(2)) can evoke coronary vasoconstriction by the oxidative quenching of nitric oxide (NO). To examine if weight loss would alter the hyperoxia-related coronary constriction seen in obese adolescents, we measured the coronary blood flow velocity (CBV) response to ...
Kotz Catherine C Department of Veterans Affairs, GRECC and Research Service, Minneapolis, Minnesota 55417, USA. - - 2012
Resistance to obesity is becoming an exception rather than the norm, and understanding mechanisms that lead some to remain lean in spite of an obesigenic environment is critical if we are to find new ways to reverse this trend. Levels of energy intake and physical activity both contribute to body ...
Astorino Todd A - - 2012
Attenuated perceptions of exertion and leg pain are typically reported during exercise with caffeine ingestion, yet these responses are relatively unexplored in women. The primary aim of this study was to assess the effect of caffeine on RPE and pain perception during a simulated time trial. Ten active women (age ...
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