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Results 401 - 450 of 833
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Thomson H - - 1997
In normal subjects during exercise, there is vasoconstriction of non-exercise resistance vessels and an increase in blood pressure. We have investigated patients with vasovagal syncope with structurally normal hearts and patients with hypertrophic cardiomyopathy compared with normal controls and found a failure of vasoconstriction in both patients with vasovagal syncope ...
Gordon A - - 1997
Heart failure syndrome is initiated as the body's metabolic needs temporarily exceed the pumping capacity of the heart. In most cases, this phenomenon tends to occur during physical exercise. Although not always subjectively recognized, limited exercise capacity remains the clinical hallmark of congestive heart failure. It can be measured objectively ...
Doering L V - - 1997
The effect of psychologic variables (situational emotional state and psychiatric diagnosis) and physiologic variables (plasma norepinephrine, decreased cardiac exercise capacity, and elevated pulmonary capillary wedge pressure) on natural killer cell activity was evaluated in 19 patients with advanced heart failure of ischemic or idiopathic origin. Only peak exercise capacity was ...
Hanayama K - - 1997
Bronchial mucous plugging is the main precipitating factor of acute respiratory failure for patients with neuromuscular disease. Manually assisted coughing and mechanical insufflation-exsufflation can effectively eliminate airway secretions without resorting to tracheal intubation provided that bulbar muscle function is sufficient to permit assisted peak cough flows of 160 l/min or ...
Guerra-Garcia H - - 1997
Congestive heart failure is one of the most common diagnoses in older women. This article reviews physiologic and pathophysiologic factors that contribute to disability in older women with normal left ejection fraction congestive heart failure; the possibility that aerobic exercise training may be an effective means to reduce the disability ...
Daida H - - 1997
Results of exercise testing in 150 patients with chronic heart failure show that women were characterized by shorter exercise time, peak oxygen consumption, and lower peak oxygen pulse than men. There was a 4.1-ml/kg/min difference in peak oxygen uptake between genders after the adjustment of age, peak heart rate, respiratory ...
Chua T P - - 1997
OBJECTIVES: This study sought to investigate the clinical characteristics of patients with chronic heart failure and an increased ventilatory response to exercise and to examine the prognostic usefulness of this response. BACKGROUND: The ventilatory response to exercise is increased in many patients with chronic heart failure and may be characterized ...
Dorszewski A - - 1997
BACKGROUND: The therapeutic benefit of an angiotensin-converting enzyme (ACE) inhibitor in combination with a different type of vasodilator is unknown. METHODS AND RESULTS: To evaluate the effects of a combined therapy on quality of life, exercise tolerance, and hemodynamic parameters, patients with severe heart failure (New York Heart Association classes ...
Cider A - - 1997
The aim of the study was to evaluate, in a controlled setting, the effects of a 5-month dynamic peripheral training programme in patients with clinical signs of congestive heart failure with special reference to their anaerobic threshold, muscle function, heart rate variability and quality of life. Twenty-four randomized patients with ...
Mills J F - - 1997
This study investigated the predictive validity of the Criminal Sentiments Scale (CSS: Gendreau, Grant, Leipciger, & Collins, 1979) within a sample of violent and sex offenders using conviction and failure on conditional release as the criterion variables. The CSS was completed by 130 male offenders (65 sex offenders and 65 ...
Walsh J T - - 1997
Symptom-limited, laboratory-based exercise tests are often used to define prognosis in patients with chronic heart failure, but they do not relate to measures of normal daily activity. Invasive measures of central hemodynamics similarly relate poorly to outcome. Pedometer scores of weekly walking are markedly reduced in patients with heart failure, ...
Leyva F - - 1997
BACKGROUND: Elevated serum uric acid concentrations have been observed in clinical conditions associated with hypoxia. Since chronic heart failure is a state of impaired oxidative metabolism, we sought to determine whether serum uric acid concentrations correlate with measures of functional capacity and disease severity. METHODS: Fifty nine patients with a ...
Harrington D - - 1997
A major aim in treating patients with chronic heart failure is to improve exercise capacity and quality of life. Experimental evidence does not support the view that central hemodynamic disturbance is the sole determinant of exercise capacity. Rather, multiple other factors including abnormalities of ventilatory control, the lungs, the peripheral ...
Mangieri E - - 1997
This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily physical activity, thus contributing to progressive deterioration of left ventricular ...
MacGowan G A - - 1997
This retrospective study of 104 New York Heart Association class 1 to 4 heart failure patients undergoing exercise stress testing with gas exchange analysis demonstrated that the ventilatory equivalent for carbon dioxide at anaerobic threshold is useful in determining prognosis in patients with severe congestive heart failure, particularly when used ...
Mancini D - - 1997
OBJECTIVES: This study investigated whether maximal exercise performance can be improved by acutely decreasing the work of breathing in these patients. BACKGROUND: Exertional dyspnea is a frequent limiting symptom in patients with heart failure. It may result from increased work of breathing. METHODS: Fifteen patients with heart failure and nine ...
Clark A L - - 1997
BACKGROUND: The aims of this study were to analyze the relationship between exercise at self-selected work loads and peak exercise performance in patients with chronic heart failure and to analyze possible relationships between gait pattern and exercise performance and ventilatory response to exercise in chronic heart failure. METHODS AND RESULTS: ...
Chua T P - - 1997
AIMS: The peripheral chemoreflex may be augmented in chronic heart failure and may play a role in its pathophysiology including the mediation of exercise hyperpnoea and sympathetic activation. The objective of this study was to characterize the patients with an augmented peripheral chemoreflex. METHODS AND RESULTS: Peripheral chemoreflex sensitivity was ...
Tikunov B - - 1997
BACKGROUND: During rest and exercise, patients with heart failure hyperventilate; therefore, the diaphragm can be viewed as undergoing constant moderate-intensity exercise. Accordingly, we hypothesized that heart failure elicits adaptations in the diaphragm similar to those elicited by endurance exercise in the limb muscles of normal subjects. METHODS AND RESULTS: Costal ...
Rundqvist B - - 1997
BACKGROUND: Cardiac norepinephrine (NE) spillover is increased in patients with chronic heart failure. This elevation is partly due to augmented NE release but also to reduced capacity for cardiac NE removal processes. In patients with mild to moderate heart failure, it is not known whether the described alteration in cardiac ...
Anker S D - - 1997
BACKGROUND: The influence of age, skeletal muscle function and peripheral blood flow on exercise capacity in chronic heart failure patients is controversial, possibly due to variations in skeletal muscle atrophy. METHODS AND RESULTS: To assess predictors of exercise capacity in patients with clinical cardiac cachexia, we studied 16 cachectic and ...
Shephard R J - - 1997
Congestive heart failure is a widely prevalent sequel to myocardial infarction and other chronic conditions (including ischaemia without infarction, hypertension, various infections, toxic metabolic and endocrine disorders). Exercise tolerance is severely limited; the cardiac ejection fraction is often less than 20% and the peak oxygen intake may be less than ...
Andrews R - - 1997
OBJECTIVE: To investigate abnormalities of skeletal muscle metabolism in patients with congestive heart failure. SETTING: A university teaching hospital. METHODS: 43 patients (22 New York Heart Association (NYHA) grade II, 21 grade III) and 10 controls were studied. A forearm model of muscle metabolism was used, with a cannula inserted ...
Madsen B K - - 1997
One hundred and ninety consecutive patients discharged with congestive heart failure were examined with clinical evaluation, blood chemistry, 24 h Holter monitoring, exercise test and radionuclide angiography. Median left ventricular ejection fraction was 0.30, 46% were in New York Heart Association class II and 44% in III. Total mortality after ...
Keteyian S J - - 1997
Reducing the exercise intolerance and symptoms experienced by patients with chronic heart failure remains an important focus in their clinical care. A clear shortcoming exists; however, with respect to an appreciation that in addition to standard medical therapy, selected patients with stable heart failure also can benefit from a moderate ...
Chua T P - - 1997
OBJECTIVES: We sought to test the hypothesis that suppression of chemosensitivity (respiratory response to arterial blood gases) with dihydrocodeine may improve dyspnea and exercise tolerance in patients with chronic heart failure. BACKGROUND: Exertional dyspnea is a common limiting symptom in patients with chronic heart failure. The mechanisms underlying this symptom ...
Poortmans J R - - 1997
There is a lack of information about renal responses in heart and kidney transplant patients after intense physical exercise. Eleven heart and ten kidney transplant recipients, as well as two control groups of healthy subjects, were given a maximum exercise test on a bicycle ergometer. One control group was also ...
Lang C C - - 1997
The purpose of this study was to determine whether skeletal muscle atrophy limits the maximal exercise capacity of stable ambulatory patients with heart failure. Body composition and maximal exercise capacity were measured in 100 stable ambulatory patients with heart failure. Body composition was assessed by using dual-energy X-ray absorption. Peak ...
Evans S A - - 1996
The cause of the breathlessness and reduced exercise capacity that occur in patients with chronic heart failure remains obscure. We examined the hypothesis that airway obstruction and bronchial hyper-responsiveness, which are recognised features of chronic heart failure, might contribute to the breathlessness and reduced exercise capacity in this condition. We ...
Chua T P - - 1996
OBJECTIVES: To assess the contribution of peripheral chemoreceptors to ventilation and the effects of continuous inspired oxygen on exercise tolerance in chronic heart failure patients. The role of peripheral chemoreceptors in mediating hyperpnoea in chronic heart failure is unknown. Hyperoxia is known to suppress the peripheral chemoreceptor drive. The magnitude ...
Yokoyama M - - 1996
Evidence is presented that not only macrophage type of NO synthase but also endothelial constitutive type of NO synthase genes are regulated by a variety of exogenous stimuli including cytokines. It is possible that pathophysiological concentrations of TNF-alpha noted in some patients with congestive heart failure may be sufficient to ...
McGowan R W - - 1996
28 college age students participating in a weight lifting class exhibited significant decreases in negative affect and increases in positive affect. Changes in affect were correlated with average exercise heart rates. Higher heart rates were correlated with reductions in negative affect and increases in positive affect. Correlations of .37 and ...
Smith G D - - 1996
The haemodynamic and catecholamine responses to supine leg exercise were studied in vasovagal syncope (n = 10), pure autonomic failure (n = 10) and in control (n = 10) subjects. With exercise, blood pressure increased in controls; with a smaller rise in vasovagal syncope, and a substantial fall in pure ...
Gullestad L - - 1996
BACKGROUND: Maximal exercise capacity is limited in patients after heart transplantation. The extent to which chronotropic incompetence contributes to this intolerance has not been well defined. METHODS: This prospective cross-sectional study examined the heart rate response to exercise and its relation to exercise capacity in 159 heart transplant recipients during ...
Milani R V - - 1996
OBJECTIVES: To evaluate whether changes in the ventilation/carbon dioxide production ratio during early exercise could reliably serve as a surrogate marker for maximal oxygen consumption in heart failure patients. Maximal oxygen consumption is an important determinant of the severity of congestive heart failure with values > 14 ml/kg/min conferring a ...
Olivari M T - - 1996
BACKGROUND: Subjective improvement and normalization of exercise tolerance are reported by most of patients after heart transplantation. However, objective measurements often do not confirm the subjective improvement. This disparate observation may be related to the methods used to test exercise tolerance. We postulated that an individualized, more gradual exercise protocol ...
Conconi F - - 1996
The protocol for the determination of the speed/heart rate relationship during incremental exercise previously described (so-called Conconi test) has been refined and in part modified during 12 years of application. The new protocol calls for time-based increments in exercise intensity that are uniform up to submaximal speeds and progressively greater ...
Sumimoto T - - 1996
Leg blood flow (LBF) and its relation to central hemodynamics were examined during recovery following maximal supine bicycle exercise in 11 patients with heart failure and 20 patients with normal exercise capacity after myocardial infarction. The results indicate that LBF was markedly reduced in patients with heart failure, and that ...
Lubsen J - - 1996
PRIMARY OBJECTIVE: To determine the effects of pimobendan 2.5 and 5 mg daily on exercise capacity in patients with chronic heart failure. DESIGN: A randomised, double blind, placebo controlled trial of the addition of pimobendan to conventional treatment with a minimum follow up of 24 weeks. SETTING: Outpatient cardiology clinics ...
Katz S D - - 1996
OBJECTIVES: This study was undertaken to investigate the role of endothelium-derived nitric oxide in the regulation of forearm blood flow during exercise in normal subjects and patients with congestive heart failure. BACKGROUND: Nitric oxide-mediated vasodilation in response to muscarinic stimulation is impaired in the peripheral circulation of patients with congestive ...
Ring C - - 1996
The heartbeat counting task is used widely to assess the ability to perceive cardiac sensations. However, performance on this task may be determined by processes other than sensitivity to cardiac stimuli. Beliefs about the effects of postural and exercise challenges on heart rate were assessed by questionnaire prior to performing ...
Chua T P - - 1996
OBJECTIVE: To investigate the airway and cough responsiveness in non-smoking patients with stable chronic heart failure. Cough and wheeze, features associated with hyper-responsive airways, are not uncommon especially in decompensated chronic heart failure. Bronchial hyperresponsiveness has previously been demonstrated in chronic heart failure but this may have been confounded by ...
Ferrari R - - 1996
OBJECTIVES: Plasma hormones at rest in patients with untreated severe congestive cardiac failure are similar to those occurring during heavy exercise in healthy people. This study examines the hypothesis that the neuroendocrine effects of exercise are modified in untreated congestive cardiac failure. DESIGN: The effect of lying, standing, upright exercise, ...
Macdonald P - - 1996
There is now considerable evidence that nitric oxide (NO) production and action are abnormal in patients with heart failure. Spontaneous NO release from the vascular endothelium is preserved or enhanced in patients with heart failure and this may help to maintain tissue perfusion by blunting the vasoconstriction induced by various ...
Kaddoura S - - 1996
BACKGROUND: No previous studies have demonstrated the changes in exercise capacity that occur during treatment of decompensated severe heart failure. The authors assessed the efficacy and safety of using a patient-powered treadmill to objectively measure exercise capacity and its relationships, if any, to symptom scores and body weight. METHODS AND ...
Mills R M RM - - 1996
Measures of disease severity used in the evaluation of patients with heart failure include survival data, the New York Heart Association classification, ejection fraction, functional assessments, exercise protocols, rest and exercise hemodynamic data, and biochemical parameters including catecholamine levels and serum sodium. Clinicians must integrate these multiple variables into an ...
Fontana J A - - 1996
A descriptive study using between-methods triangulation was conducted to explore perceptions of vigor in heart failure and the role that planned exercise played in these perceptions. Fifty-four people with heart failure were surveyed about perceived health, mental health, physical functioning, and vigor. Average energy expenditure in planned exercise, ventricular function, ...
Lubsen J - - 1996
In 5 separate exercise capacity trials in similar patients with chronic congestive heart failure performed in Europe, the United States, and South Africa, 627 patients were randomized to ramipril and 428 to placebo. The dose of ramipril ranged from 1.25 to 20 mg/day. Follow-up was at 12 or 24 weeks. ...
Camm A J - - 1996
Knowledge of normal adjustment of heart rate and its response to exercise is essential for understanding and management of chronotropic incompetence. The autonomic nervous system plays an important role in the modulation of normal heart rate. Chronotropic responses of a normal heart to exercise are associated with parallel hemodynamic changes ...
Andreas S - - 1996
OBJECTIVES: The aim of this study was to determine the impact of nasal nocturnal oxygen therapy on respiration, sleep, exercise capacity, cognitive function and daytime symptoms in patients with congestive heart failure and Cheyne-Stokes respiration. BACKGROUND: Cheyne-Stokes respiration is common in patients with congestive heart failure and is associated with ...
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