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Lebrun Frederic - - 2006
BACKGROUND: Intracoronary infusion of autologous bone marrow cells (CTX) has been shown to improve myocardial function in postinfarct patients and in patients with chronic ischemic cardiomyopathy. Whether CTX affects exercise-induced changes in cardiac deformation and mitral regurgitation (MR) in patients with end-stage heart failure has not been studied. METHODS AND ...
Giardini Alessandro - - 2006
BACKGROUND: Experimental studies showed that extracardiac total cavopulmonary connection provides superior hemodynamics than atriopulmonary Fontan. METHODS: We prospectively assessed the impact of conversion of atriopulmonary Fontan to extracardiac total cavopulmonary connection on exercise capacity and cardiac function in 6 consecutive patients. RESULTS: Six months after conversion to extracardiac total cavopulmonary ...
Thomas Kuruvilla
A 73-year-old woman with dementia was given clozapine for treatment-resistant psychotic symptoms. Subsequently, she developed cardiac failure. Caution should be exercised when using clozapine, especially in the elderly.
Parish, Tracie Rena
The goal of this research was to gain greater understanding about the management of heart failure patients. A particular focus was to evaluate exercise tolerance and behavior. The major findings of the first study included: (1) evidence that few heart failure patients receive adequate information regarding physical activity; (2) performance ...
Arena Ross - - 2005
BACKGROUND: Cardiopulmonary exercise testing (CPET) in the heart failure population is a standard of care in both American and European clinics, although the mode of exercise typically differs. The purpose of the present study was to compare the prognostic characteristics of peak oxygen consumption (VO2) and the minute ventilation-carbon dioxide ...
Smart Neil - - 2005
BACKGROUND: Exercise training (ExT) improves exercise capacity in chronic heart failure, but the results of home-based training have been variable. We sought the predictors of favorable outcome using a telemonitoring approach. METHODS: Exercise capacity and quality of life (QOL) were assessed in 30 patients (28 men, age 64 +/- 8 ...
Wensel Roland - - 2005
Patients with heart failure have an abnormally high ventilatory response to exercise associated with gas exchange defects and reduced arterial pCO(2). We examined the possibility of lactic acidosis as the stimulus to this increased ventilation that abnormally depresses pCO(2) during exercise in heart failure. We studied 18 patients with chronic ...
Smith Scott A - - 2005
BACKGROUND: In heart failure, exercise elicits excessive increases in mean arterial pressure (MAP) and heart rate (HR). Using a novel rat model, we previously demonstrated that this exaggerated cardiovascular responsiveness is mediated by an overactive exercise pressor reflex (EPR). Although we previously determined that abnormalities in the group IV afferent ...
Kohno Takashi - - 2005
It is still uncertain whether or not there is a difference between metoprolol and carvedilol for the treatment of congestive heart failure. We attempted to determine the difference between the two beta-blockers in terms of their antiadrenergic effect during exercise in patients with heart failure and their efficacy based on ...
Ellis Shmuel - - 2005
The claim that appropriate after-event review might decrease the relative advantage of drawing lessons from failures over drawing lessons from successes was examined in a quasi-field experiment. The results show that performance of soldiers doing successive navigation exercises improved significantly when they were debriefed on their failures and successes after ...
Anand Inder S - - 2005
BACKGROUND: The role of C-reactive protein (CRP) in heart failure is not well studied. We assessed the prognostic value of CRP in patients randomized in Val-HeFT (Valsartan Heart Failure Trial) and studied changes in CRP that were associated with valsartan. METHODS AND RESULTS: Characteristics of patients with baseline CRP levels ...
Larsen A I - - 2005
Traditionally exercise training was considered contraindicated in heart failure patients. However, during the last 15 years numerous small studies have demonstrated that training is safe in stable heart failure patients and that this intervention improves quality of life in this population. The beneficial effects include improved autonomic balance, reduced neurohumoral ...
Diller Gerhard-Paul - - 2005
BACKGROUND: Although some patients with adult congenital heart disease (ACHD) report limitations in exercise capacity, we hypothesized that depressed exercise capacity may be more widespread than superficially evident during clinical consultation and could be a means of assessing risk. METHODS AND RESULTS: Cardiopulmonary exercise testing was performed in 335 consecutive ...
Cleland John G F - - 2005
This article provides information and a commentary on landmark trials presented at the European Society of Cardiology Heart Failure meeting held in June 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. ...
Kiyono Ken - - 2005
A healthy human heart rate displays complex fluctuations which share characteristics of physical systems in a critical state. We demonstrate that the human heart rate in healthy individuals undergoes a dramatic breakdown of criticality characteristics, reminiscent of continuous second order phase transitions. By studying the germane determinants, we show that ...
Rovner Aleksandr - - 2005
We sought to elucidate the relationship between diastolic intraventricular pressure gradients (IVPG) and exercise tolerance in patients with heart failure using color M-mode Doppler. Diastolic dysfunction has been implicated as a cause of low aerobic potential in patients with heart failure. We previously validated a novel method to evaluate diastolic ...
Blanchet Martine - - 2005
BACKGROUND: In patients with symptomatic congestive heart failure receiving optimal therapy with an angiotensin-converting enzyme (ACE) inhibitor and a beta-blocker, the impact of using an angiotensin receptor blocker on submaximal exercise capacity and on neurohumoral activation at rest and during stress has not been investigated. METHODS: Thirty-three patients with congestive ...
Kitzman Dalane W - - 2005
Patients with heart failure and normal EF have severe chronic exercise intolerance. The pathophysiology of exercise intolerance in this syndrome is incompletely understood, but as in systolic heart failure, it is likely multifactorial. Current data suggest that important contributors include decreased LV diastolic compliance, decreased aortic distensibility, exaggerated exercise systolic ...
Smith Scott A - - 2005
BACKGROUND: In heart failure, the cardiovascular response to activation of the skeletal muscle exercise pressor reflex (EPR) is exaggerated. Group IV afferent neurons, primarily stimulated by the metabolic by-products of skeletal muscle work, contribute significantly to the EPR. Therefore, it was postulated that alterations in the activity of group IV ...
Feldman Arthur M - - 2005
BACKGROUND: Enhanced external counterpulsation (EECP) treatment can improve exercise tolerance in patients with ischemic heart disease; however, the possible benefits of EECP in patients with stable heart failure (HF) and left ventricular dysfunction (LVD) are unclear. An open pilot study showed significant increases in exercise tolerance in HF patients undergoing ...
Arzt Michael - - 2005
OBJECTIVES: Chronic heart failure is closely related to impaired cardiorespiratory reflex control, including decreased ventilatory efficiency during exercise (Ve/Vco(2)-slope) and central sleep apnea (CSA). Continuous positive airway pressure (CPAP) and nocturnal oxygen therapy alleviate CSA. The aim of the present study was to compare the effects of nocturnal CPAP and ...
Hernáindez-Falcón Jesús - - 2005
Agonistic contests between lobsters housed together in a confined space progress through encounters of increasing intensity until a dominance relationship is established. Once this relationship is established, losing animals continually retreat from the advances of winners. These encounters are likely to consume much energy in both winning and losing animals. ...
Wolfel Eugene E - - 2005
Patients with chronic heart failure have diminished exercise capacity as a major aspect of their clinical syndrome, regardless of the cause of their left ventricular contractile dysfunction. The mechanisms for the reduction in exercise capacity are multifactorial and include central cardiac, peripheral vascular, respiratory, and skeletal muscle maladaptations that accompany ...
McConnell T R - - 2005
The patient with heart failure relies on varied physiological adaptations to exercise training. Although, the cardiovascular adaptations may be limited, the patient with heart failure relies on changes in the pulmonary system as well as peripheral muscular adaptations. Therefore, the intent of this review is to outline effective exercise program ...
Hagerman I - - 2005
AIMS: Heart failure is a major cause of hospitalisation, particularly in patients more than 65 years of age in the western world. A common endpoint in studies designed to evaluate treatment effects in heart failure is mortality and morbidity, often reported as an event of hospitalisation. It has recently been ...
Tanne David - - 2005
BACKGROUND: Congestive heart failure is associated with cognitive impairment, particularly of attentional skills. We assessed, in a hypothesis-generating study, the effect of an exercise training program on cognitive functions among patients with severe congestive heart failure. METHODS: Patients with severe congestive heart failure (n=20; New York Heart Association functional class ...
Chambers David W - - 2005
There is a part of our mental functioning that makes decisions and executes them and another part that monitors and regulates the first part. When these operations are in balance, we may be said to exercise self-control. There is evidence that these functions operate in different parts of the brain. ...
Benton Melissa J - - 2005
Although a rich body of research exists regarding the safety and efficacy of resistance training, health care providers continue to caution patients with heart failure not to engage in this type of exercise. Research studies utilizing resistance training demonstrate improvements in muscular strength and endurance, New York Heart Association functional ...
Van Laethem Christophe - - 2005
BACKGROUND: The oxygen uptake efficiency slope (OUES) is a new submaximal parameter which objectively predicts the maximal exercise capacity in children and healthy subjects. However, the usefulness of OUES in adult patients with and without advanced heart failure remains undetermined. The present study investigates the stability and the usefulness of ...
McLoda T A - - 2005
Ankle inversion injuries represent the most common trauma sustained by athletes. Muscle fatigue from activity may contribute to a delay in the response of the ankle proprioceptors and dynamic restraints during unexpected inversion. The purpose of this investigation was to determine changes in peroneal average EMG, peak EMG, and time ...
Su S W SW Human Performance Lab, School of Electrical Engineering & Telecommunications, University of New South Wales,UNSW SydneyN.S.W. 2052 Australia. Email address: - - 2005
A computer-controlled treadmill and related data collection and processing systems have been developed for the control of heart rate during treadmill exercise. Minimizing deviations of heart rate from a preset profile is achieved by controlling the speed and/or the gradient of the treadmill. A simple and practical heart rate measurement ...
Lee Mi-Hee MH Interaction Lab., Samsung Adv. Inst. of - - 2005
A measuring device for use in measuring calorie consumption includes a pulse input unit which detects a first heart rate of the user at a first point in an exercise period and a second heart rate of the user at a second point of the exercise period other than the ...
Jorde Ulrich P - - 2004
Experimental studies suggest that angiotensin-converting enzyme (ACE) inhibitors with high tissue affinity confer a greater degree of vascular renin-angiotensin system suppression than those with low tissue affinity despite similar suppression of the circulating renin-angiotensin system. To test this hypothesis in a clinical setting, we randomized subjects with chronic heart failure ...
Piña I L - - 2004
This report will review the abnormalities of the peripheral circulation and skeletal muscle which are part of the heart failure syndrome and can limit exercise tolerance; introduce trials that have shown benefits of exercise training in a variety of heart failure patients; suggest strategies for recommending activity training in patients ...
Yum Myung-Kul - - 2004
An abnormality in cardiovascular regulation during the prenatal period has been suggested to be the pathophysiological link between fetal growth restriction and adult hypertension. The purpose of this study was to determine how consistently abnormal the local smoothness of the very-short-term heart rate is in growth-restricted fetuses associated with severe ...
Yamada Kunihiro - - 2004
BACKGROUND: Enhanced central hypercapnic chemosensitivity is known to mediate excessive exercise ventilation and to indicate a poor prognosis in patients with chronic heart failure. The present study was designed to elucidate the role of central sympathetic activity in the enhancement of hypercapnic chemosensitivity. METHODS: Central hypercapnic chemosensitivity and plasma norepinephrine ...
Yeh Gloria Y - - 2004
PURPOSE: To examine the effects of a 12-week tai chi program on quality of life and exercise capacity in patients with heart failure. METHODS: Thirty patients with chronic stable heart failure and left ventricular ejection fraction < or =40% (mean [+/- SD] age, 64 +/- 13 years; mean baseline ejection ...
Nishiyama Yasuhiro - - 2004
BACKGROUND: The effect of physical training (PT) on QTc dispersion and ventricular tachycardia (VT) remains unclear in patients with nonischemic heart failure. METHODS AND RESULTS: Eight patients with nonischemic heart failure performed PT using a bicycle ergometer and their exercise tolerance increased (4.9+/-1.8 to 7.0+/-2.5 METs, p<0.05) and QTc dispersion ...
Levinger Itamar - - 2005
BACKGROUND: Resistance training increases the skeletal muscle strength and functional ability of chronic heart failure patients. However, there is limited data regarding the effect of resistance training on the hemodynamic responses and peak oxygen consumption (peak VO(2)) of chronic heart failure patients treated with beta-blocker. This study examined the effect ...
Corrà Ugo - - 2004
The identification of individuals who are at high risk of chronic heart failure (HF) is a medical art of growing concern. Cardiopulmonary exercise stress testing (CPX) has become an important clinical tool to predict outcome. The value of peak oxygen consumption rests in the fact that it integrates elements of ...
McConnell Timothy R - - 2004
The exaggerated ventilatory response in patients with heart failure is clearly multifactorial and complex beyond a mere reduction in pulmonary blood flow. Pulmonary dysfunction, including ventilation-perfusion mismatching, decreased lung compliance, restriction, airway obstruction, decreased diffusion capacity, and decreases in respiratory muscle strength and endurance, contributes to an inefficient breathing pattern ...
Rosenberg Paul - - 2004
Several inherited and acquired disorders of mitochondria lead to defects in cardiac function as reflected in exercise intolerance, arrhythmias and heart failure. Manifestations of mitochondrial dysfunction is reflected in the abnormal mitochondrial proliferation, structure and ultimately as cytochrome C-induced apoptosis. How these defects are associated with disordered cytosolic events including ...
Icardo José M - - 2004
This paper presents a sequential analysis of the development of the sturgeon (Acipenser naccarii) heart from the end of gastrulation to the early juvenile stages. At late neurulation, the heart appears as a straight, short tube located over the endoderm that forms the wall of the yolk sac, in front ...
Lamberts Robert P - - 2004
A change in heart rate at a controlled submaximal exercise intensity is used as a marker of training status. However, the standard error of measurement has not been studied systematically, and therefore a change in heart rate, which can be considered relevant, has not been determined. Forty-four subjects (26.5 +/- ...
Bussotti Maurizio - - 2004
In heart failure abnormalities of pulmonary function are frequently observed as shown by hyperpnea, reduced lung compliance, reduced alveolar-capillary gas diffusion, positive methacholine challenge and, during exercise, early expiratory flow limitation. Nitric oxide (NO) might be related to all the above abnormalities. We evaluated whether a correlation between exhaled NO ...
Zucker Irving H - - 2004
In this review, we put forth the hypothesis that reduction in sympathetic outflow after exercise training of animals with heart failure is mediated by reductions in angiotensin II and in angiotensin type 1 receptors. Furthermore, we provide evidence that exercise training provides for an upregulation of the neuronal isoform of ...
Thrainsdottir Inga S - - 2004
Congestive heart failure and type 2 diabetes have a deleterious prognosis when combined. Trimetazidine, a metabolic agent with anti-ischemic properties, reduces fatty acid beta-oxidation via decreased 3-ketoacyl-coenzyme-A thiolase activity thereby facilitating energy production via the glycolytic pathway. OBJECTIVES: To assess myocardial function by Tissue Doppler Imaging (TDI) after one month ...
Jeng Chii - - 2004
The purpose of this study was to explore the influence of exercise tolerance on quality of life (QOL) among patients with heart failure (HF). A descriptive correlational design was used to guide the study. Forty-nine participants who met the selection criteria were enrolled at a medical center in Taipei. Data ...
Rosen Stuart D SD Department of Respiratory Physiology, National Heart and Lung Institute, Imperial College, Charing Cross Hospital, London W68RP, UK. - - 2004
Breathlessness is a cardinal symptom of heart failure and the altered regulation of breathing is common. The contribution of abnormal central nervous system activity has not previously been investigated directly, although abnormal autonomic responses have been described. Our aim was to assess whether heart failure patients exhibit different patterns of ...
Collins Eileen - - 2004
PURPOSE: The purpose of this study was to determine whether subjects with chronic heart failure, who completed a 12-week rehabilitation program, would have significantly greater quality of life, better aerobic fitness, less difficulty with symptoms of heart failure, greater self-efficacy for exercise, and higher daily activity levels when compared with ...
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