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Results 601 - 650 of 833
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Ajayi A A - - 1990
A single blind, placebo controlled, dose-ranging 3 month study of the effects of enalapril on cardiovascular parameters, clinical status and self-paced exercise capacity was undertaken in 12 Nigerians with chronic heart failure. Enalapril exerted only a modest reduction in blood pressure and heart rate but significantly improved functional capacity (P ...
Blackwood R - - 1990
In a double-blind study comparing two active treatments (digoxin and xamoterol) and placebo in patients with heart failure, improvements in exercise capacity and quality of life were observed in all three groups, with no significant differences. The substantial benefits seen in the placebo group were probably the result of increased ...
Vigholt-Sørensen E - - 1990
The long term effects of treatment with xamoterol in 14 patients aged 44-73 with mild to moderate heart failure as a result of ischaemic heart disease are reported. After 18 months' treatment with xamoterol, patients were assessed in a randomised double blind crossover comparison of xamoterol (200 mg twice a ...
Erlemeier H H - - 1990
In order to assess potential harmful effects of the partial beta-1 agonist xamoterol during long-term therapy, we randomly assigned 30 patients with coronary arterial disease and heart failure in classes II and III of the classification of the New York Heart Association to 200 mg of xamoterol twice daily or ...
Rackow E C - - 1990
The primary defect that characterizes circulatory shock is acute perfusion failure, in which oxygen metabolism is critically impaired by decreased delivery of oxygen to tissues. Four categories of hemodynamic deficits are described as the basic mechanisms of circulatory shock: hypovolemia, cardiac failure, distributive deficits, and vascular obstruction. Perfusion failure can ...
- - 1990
516 patients with New York Heart Association class III and IV heart failure despite treatment with diuretics and angiotensin converting enzyme inhibitors were randomised in a double-blind between-group comparison to xamoterol 200 mg (352) or placebo (164) twice daily for 13 weeks. There was no difference between the treatments in ...
Solal A C - - 1990
Prediction of oxygen uptake (VO2) during exercise from relations established in normal subjects between VO2 and work load in watts (W) may be inaccurate in patients with chronic heart failure because these patients could manifest delayed VO2 kinetics at final stages of exercise. To test the hypothesis that even at ...
Cowley A J - - 1990
Ten patients with severe heart failure, symptomatic despite treatment with diuretics and captopril, completed a study of the effect of adding enoximone to their normal treatment. Enoximone or matching placebo was given for 4 weeks in randomized double-blind order following a single-blind placebo run-in period. Exercise capability was measured with ...
Elborn J S - - 1990
The transcutaneous partial pressure of oxygen measured in the lower limb was compared in 16 patients with chronic cardiac failure and seven normal subjects. At rest, there was no significant difference between patients and normals. At peak exercise, the partial pressure of oxygen fell significantly in those in heart failure, ...
Riley M - - 1990
1. Skeletal muscle metabolism in chronic cardiac failure may be influenced by the many circulatory and neurohumoral adaptations in the condition. We investigated aerobic metabolism during exercise using indirect calorimetry in 15 patients with chronic cardiac failure and in 14 control subjects. Subjects exercised on a treadmill for 20 min ...
DiBianco R - - 1990
The renin-angiotensin-aldosterone system (RAAS) has been implicated in the pathogenesis of congestive heart failure (CHF). Abnormal activation of the RAAS adversely affects cardiac performance and impairs functional status, increasing both afterload and preload through direct and indirect mechanisms. Conventional first-line therapy for CHF consists of diuretics and/or digitalis. Diuretics offer ...
Miers L J - - 1990
Individuals with moderate to severe heart failure may benefit from cardiac fitness training. However, before recommending cardiac rehabilitation to this patient population, nurses must understand exercise physiology and the effects of exercise in the individual with chronic left ventricular dysfunction (LVD). Normal cellular response to exercise, normal cardiovascular responses associated ...
Elborn J S - - 1990
1. Twenty patients with moderate to severe chronic cardiac failure were entered into a double-blind parallel group study comparing flosequinan 100 mg daily with matching placebo. 2. After at least three prior exercise tests, cardiopulmonary parameters were assessed at rest and during submaximal exercise before and after 2 and 8 ...
Buller N P - - 1990
Minute ventilation, respiratory rate, and metabolic gas exchange were measured continuously during maximal symptom limited treadmill exercise in 30 patients with stable chronic heart failure. The ventilatory response to exercise was assessed by calculation of the slope of the relation between minute ventilation and rate of carbon dioxide production. There ...
Kupper W - - 1990
Xamoterol is a beta 1-selective adrenoceptor partial agonist. The acute effects of xamoterol were studied in 30 patients with ischaemic heart failure. Haemodynamic data were assessed at baseline, at rest and after supine bicycle exercise (50 W for 3 min), and repeated 15 min after xamoterol (0.2 mg kg-1) given ...
Ajayi A A - - 1990
We investigated the relationships between the cardiothoracic ratio, M-mode echocardiographic indices and symptom-limited, self-paced exercise tolerance in 8 Nigerian patients with chronic stable congestive heart failure. Left ventricular diastolic dimension was inversely related to exercise duration; thus: log exercise time (sec) = 6.142-0.057x (r2 = 0.83, P less than 0.05), ...
Haerer W - - 1990
To evaluate the acute and chronic effects of diuretic monotherapy with 3 mg piretanide bid, 46 patients (pts) with congestive heart failure (NYHA II-III) secondary to coronary artery disease were studied. Within 3 weeks of therapy, the patients lost 1.6 kg body weight. Forty-four patients reported a subjective feeling of ...
Dargie H - - 1990
The syndrome of heart failure results from inappropriate sodium and water retention by the kidneys which results, at least in part, from changes in renal haemodynamics. Renal blood flow at rest in heart failure is reduced in proportion to the reduction in cardiac output and falls dramatically during exercise as ...
Kayanakis J G - - 1990
The long-term efficacy of xamoterol in improving effort capacity and haemodynamics was investigated in a study lasting 1 year in heart failure patients. Following a 3 month, double-blind period of treatment with xamoterol, patients continued therapy for a further 9 months. Exercise duration rose by 27% at 3 months and ...
Roubin G S - - 1990
Hemodynamic and metabolic changes were measured at rest and during exercise in 23 patients with chronic heart failure and in 6 control subjects. Exercise was limited by leg fatigue in both groups and capacity was 40% lower in the patients with failure. At rest, comparing patients with control subjects, heart ...
- - 1990
Xamoterol, 200 mg b.d. was compared with digoxin 0.125 mg b.d. or t.d. in a 3-month double-blind trial in 178 patients with mild to moderate heart failure. Xamoterol and digoxin both significantly increased exercise duration, but greater changes were observed with xamoterol. Xamoterol also improved quality of life to a ...
Tweed J A - - 1990
A patient-powered treadmill was compared with the covered corridor walking test as assessments of exercise capacity in heart failure patients, and used to investigate their sensitivity in discriminating between the effects of xamoterol and placebo. The two methods were comparable, and sufficiently sensitive to demonstrate improvements in exercise capacity on ...
Ollivier J P - - 1990
The effects of xamoterol on haemodynamics and plasma catecholamines were studied at rest and after exercise in patients with mild to moderate heart failure, using a symptom-limited exercise test. Exercise duration and myocardial efficiency were significantly increased, and heart rate on maximal exercise was reduced despite increased catecholamine levels.
Pieter W - - 1990
The telemetered exercise and recovery heart rates of seven male recreational taekwondo students were recorded while they were performing two different beginner's forms (one with only arm techniques and one with both arm and leg techniques) and two sets of technique combinations, one set consisting of only kicks and the ...
Langton D - - 1990
1. The effects of graded treadmill exercise on renal blood flow (RBF) were examined in seven rabbits, in which congestive heart failure (CHF) was produced by the administration of doxorubicin, 1 mg/kg, twice weekly for 8 weeks, and in seven controls. A third group of five rabbits underwent doxorubicin treatment ...
Imachi Y - - 1990
When measured continuously, the heart rate often appears to hesitate in its elevation momentarily in the early stage of exercise. This phenomenon was called tentatively "a point of discontinuity on a heart rate curve", and was observed in 19 out of 30 healthy subjects. The point appeared when the heart ...
Gilbert E M - - 1990
PURPOSE: Bucindolol is a potent nonselective beta-blocking agent with vasodilatory properties. In this study, we evaluated the effects of long-term bucindolol therapy in the treatment of heart failure from idiopathic dilated cardiomyopathy. PATIENTS AND METHODS: Patients were eligible for enrollment if they had symptomatic heart failure, idiopathic dilated cardiomyopathy, and ...
Corbalán R - - 1990
The potential adverse consequences of increased adrenergic nervous system activity in patients with heart failure are now recognized. Modulation of the plasma noradrenaline response to submaximal exercise should be desirable. The long-term (9 weeks) effects of milrinone (10 mg 4 times a day) or captopril (50 mg 3 times a ...
Dunselman P H - - 1990
We evaluated the cardiopulmonary exercise test results before and after long-term (16 weeks) treatment with the dihydropyridine calcium antagonist, felodipine (10 mg b.i.d., n = 9), and the ACE inhibitor, enalapril (10 mg b.i.d., n = 11), in 20 patients with New York Heart Association class III congestive heart failure. ...
Maisel A S - - 1990
The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three settings: congestive heart failure, dynamic exercise, and beta-adrenergic agonist treatment. We compared the number and subset distribution of circulating lymphocytes in 36 patients with congestive heart failure and 31 age-matched ...
Marlow H F - - 1990
The sympathetic nervous system becomes activated in heart failure, and while this is initially beneficial, the consequences of prolonged raised levels of catecholamines can be counterproductive. Xamoterol, a partial agonist that acts on the cardiac beta 1-adrenergic receptor, modifies the response of the heart to variations in sympathetic activity. At ...
Coats A J - - 1990
Eleven patients with chronic heart failure secondary to ischaemic heart disease (mean [SEM] age 63.0 [2.3] years; left ventricular ejection fraction 19 [8]% undertook 8 weeks of home-based bicycle exercise training and 8 weeks of activity restriction (rest) in a physician-blind, random-order, crossover trial. Training increased exercise duration from 14.2 ...
Itoh H - - 1990
To evaluate the severity of heart failure, cardiopulmonary exercise testing was performed in 99 normal subjects and in 382 patients with cardiac disease. Anaerobic threshold, peak oxygen uptake, and the ratio of increase in oxygen uptake to work-rate increment were determined by ventilatory and gas exchange measurements as indexes for ...
Janicki J S - - 1990
Present-day technology has greatly facilitated the monitoring of respiratory gas exchange in the clinical exercise laboratory. Despite the growing use of these techniques to assess the severity and progression of disease or therapeutic response in patients with heart failure, the long-term reproducibility of oxygen uptake (VO2), carbon dioxide production, minute ...
Ribeiro J P - - 1990
1. The acute administration of milrinone, a positive inotropic vasodilator agent, improves resting hemodynamic function and maximal and submaximal metabolic responses to exercise in patients with severe congestive heart failure. 2. To determine whether the improvement in exercise capacity induced by milrinone administration can be predicted by its acute positive ...
Shabetai R - - 1990
Xamoterol is a beta-adrenoceptor partial agonist which selectively acts at the beta 1-receptors of the heart. The partial agonist effect modestly increases myocardial contractility and appears also to improve diastolic function and cardiac output without an increase in myocardial oxygen demand. Improved myocardial performance is maintained during exercise while increased ...
Lovallo W R - - 1990
The present paper examines the neuroendocrine influences of aversive and reward incentives (noise and shock versus monetary bonuses) presented during reaction time tasks administered to 71 healthy men (ages 21 to 35) classified as being high (N = 30) or low (N = 41) in heart rate reactivity. High heart ...
Johnston D W - - 1990
The psychophysiological responses to laboratory stressors are often examined because it is believed that such responses relate to responsiveness in real life situations. This belief has seldom been tested. The changes in heart rate, pulse transit time, and respiration rate produced by a variety of laboratory tasks (active and passive ...
Tan L B - - 1989
When the peripheral vascular resistance is abnormally high, the heart can be considered to be pumping inefficiently in that much of its effort is wasted in overcoming the extra high load. Patients with such conditions are liable to have reduced exercise capacity (ExC). It is unclear whether selective arterial vasodilation ...
Wilson J R - - 1989
The present study was undertaken to determine whether near-infrared spectroscopy can be used to noninvasively assess skeletal muscle oxygenation in patients with heart failure. The difference between light absorption at 760 and 800 nm was used to assess hemoglobin-myoglobin oxygenation. Initial studies conducted in isolated canine gracilis muscle demonstrated that ...
Waller D G - - 1989
The clinical efficacy of xamoterol, alpha beta 1-adrenoceptor partial agonist, was determined in a multicentre double-blind, randomized, parallel group study of 240 patients with mild to moderate heart failure. At entry, 62% of patients were receiving diuretics (thiazides, or loop diuretics at a dose no greater than the equivalent of ...
Nakajima H - - 1989
The acute effects of vasodilation on exercise capacity in cardiac patients with (group 1) and without (group 2) congestive heart failure were studied using dibutyryl cyclic AMP (DBcAMP). Exercise was performed on an upright bicycle ergometer using a graded protocol. DBcAMP increased cardiac output and decreased pulmonary capillary wedge pressure ...
Labovitz A J - - 1989
Few data are available examining the influence of perioperative clinical parameters on exercise capacity after cardiac transplantation. Accordingly, 40 patients were studied by metabolic exercise testing early (1 to 3 months) and late (6 to 12 months) after cardiac transplantation. Various clinical parameters, including congestive heart failure class, length of ...
Thomas P - - 1989
1. Haemodynamic responses to exercise, posture and nitrates were measured before and after 8 weeks of therapy with an arteriolar smooth muscle specific calcium antagonist, nicardipine, in eight patients with congestive heart failure (New York Heart Association class II or III). 2. The acute haemodynamic effects of intravenous nicardipine before ...
B?hm M - - 1989
1. The present study was designed to characterize the positive inotropic response to DPI 201-106 in isolated papillary muscle strips obtained from heart failure patients undergoing surgery. 2. The positive inotropic responses to isoprenaline and milrinone and cardiac beta-adrenoceptor density were also determined. 3. DPI 201-106 increased the force of ...
Cowley A J - - 1989
The effects of enoximone, a new cyclic adenosine monophosphate phosphodiesterase inhibitor, were compared with those of captopril in a double-blind study in a group of 10 patients with severe heart failure. Four weeks treatment with enoximone improved symptom-limited exercise tolerance from a mean value of 11.33 to 13.36 minutes (P ...
Turner J R - - 1989
This program of experiments examined heart rate responses to mental arithmetic and a video game. Attention first focused on their metabolic relevance. Comparison with heart rate/oxygen consumption regression equations generated from isotonic exercise data revealed that the heart rate increases of certain individuals were considerably in excess of those necessitated ...
DiBianco R - - 1989
Clinical evaluation of oral milrinone in moderate to severe heart failure has demonstrated pronounced beneficial effects. These effects are achieved through increased cardiac index and exercise tolerance, and reduced ventricular filling pressure and systemic vascular resistance. In a double-blind, multicentre study of 230 patients with moderate to severe failure receiving ...
Hidalgo R - - 1989
To evaluate the circulatory response of the denervated heart to exercise, the authors studied 15 patients with an orthotopic transplanted heart (TH). Mean age was 48 +/- 10 (range twenty-five to sixty-two) years. All patients underwent a symptom-limited bicycle stress testing following a continuous protocol increasing the work load by ...
Leier C V - - 1989
Twenty patients with moderately severe congestive heart failure were randomized to chronic enoximone (n = 10) or placebo (n = 10) therapy in a double-blind manner and serially evaluated over a 16-week-period. The purpose of the study was to determine if the addition of standard doses (1 and 2 mg/kg) ...
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