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Li Menglin M National Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, 5 Dong Dan San Tiao, Beijing, China, - - 2015
The most important of nature of biomarker is changes. Blood is under strict homeostatic control which means changes tend to be removed from blood. Urine is a partial filtrate of blood, reflects systemic physiology but with no homeostatic mechanism. However, changes induced directly into the blood can be more sensitively ...
Rasmussen Peter M PM Department of Clinical Medicine, Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University Hospital, Aarhus, - - 2014
The interpretation of regional blood flow and blood oxygenation changes during functional activation has evolved from the concept of 'neurovascular coupling', and hence the regulation of arteriolar tone to meet metabolic demands. The efficacy of oxygen extraction was recently shown to depend on the heterogeneity of capillary flow patterns downstream. ...
Bisdas Sotirios S Department of Neuroradiology, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany, - - 2014
We sought to investigate the dependence of intravoxel incoherent motion (IVIM)-related perfusion fraction (f) estimates on the transverse relaxation of brain tissue, blood, and cerebrospinal fluid (CSF), attempting to overcome the influence of CSF on conventional f maps. Eighteen patients with gliomas underwent DWI with 14 b-values (0-1,300 s/mm(2)) and two ...
Miguel-Montanes Romain R 1Medico-Surgical Intensive Care Unit, Hôpital Louis Mourier, AP-HP, Colombes, France. 2Department of Epidemiology and Clinical Research, Hôpital Louis Mourier, AP-HP, Colombes, France. 3Institut National de la Santé et de la Recherche Médicale (INSERM), IAME, UMR 1137, F-75018, Paris, France. 4Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, F-75018, Paris, - - 2014
Tracheal intubation of ICU patients is frequently associated with severe hypoxemia. Although noninvasive ventilation reduces desaturation during intubation of severely hypoxemic patients, it does not allow for per-procedure oxygenation and has not been evaluated in mild-to-moderate hypoxemic patients for whom high-flow nasal cannula oxygen may be an alternative. We sought ...
Brainard Andrew A Middlemore Hospital, Auckland, New Zealand; University of Auckland Medical School, Auckland, New Zealand. Electronic address: - - 2014
Experts advocate the use of a standard nasal cannula to provide oxygen at flow rates of up to 15 L/minute during emergency intubation. However, because of concerns about potential patient discomfort, some providers avoid providing nasal cannula oxygen at flow rates greater than 6 L/minute. This trial is designed to determine ...
Lücker Adrien A ETH Zurich - - 2014
Most oxygen required to support the energy needs of vertebrate tissues is delivered by diffusion from microvessels. The presence of red blood cells (RBCs) makes blood flow in the microcirculation highly heterogeneous. Additionally, flow regulation mechanisms dynamically respond to changes in tissue energy demand. These spatio-temporal variations directly affect the ...
Kam A W AW St. Vincent's Clinical School,Faculty of Medicine,University of New South - - 2014
Background: Nasal dilator strips are thought to widen and stiffen the anterior nasal cavity, and thus improve symptoms of nasal obstruction. It is postulated that anthropomorphic differences in external nasal proportions between races may influence the effectiveness of such dilator strips. Methods: Caucasian and Asian subjects were compared. Nasal peak ...
Kang Min-Yeong MY Physique de la Matière Condensée, CNRS, Ecole Polytechnique, 91128 Palaiseau, - - 2014
Oxygen capture in the lung results from the intimate dynamic interaction between the space- and time-dependent oxygen partial pressure that results from convection-diffusion and oxygen extraction from the alveolar gas and the space and time dependence of oxygen trapping by the red blood cells flowing in the capillaries. The complexity ...
Willie Christopher K CK Centre for Heart, Lung, and Vascular Health, School of Health and Exercise, Sciences, University of British Columbia-Okanagan, Kelowna, British Columbia, - - 2014
The roles of involuntary breathing movements (IBMs) and cerebral oxygen delivery in the tolerance to extreme hypoxemia displayed by elite breath-hold divers are unknown. Cerebral blood flow (CBF), arterial blood gases (ABGs), and cardiorespiratory metrics were measured during maximum dry apneas in elite breath-hold divers (n=17). To isolate the effects ...
Croal Paula L PL Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, - - 2014
The physiological effect of hyperoxia has been poorly characterised, with studies reporting conflicting results on the role of hyperoxia as a vasoconstrictor. It is not clear whether hyperoxia is the primary contributor to vasoconstriction or whether induced changes in CO2 that commonly accompany hyperoxia are a factor. As calibrated BOLD ...
Bembich Stefano S Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, - - 2014
This study evaluates the effect of varying nasal continuous positive airway pressure (NCPAP) level on cerebral blood flow (CBF) and oxygenation in preterm infants. Oxy-haemoglobin (HbO2) and total haemoglobin (HbTot), as CBF estimates, and the ratio between HbO2 and HbTot (HbO2/HbTot), as cerebral oxygenation estimate, were assessed by near-infrared spectroscopy ...
Ménétrier A A EA3920 Marqueurs Pronostiques et Facteurs de Régulations des Pathologies Cardiaques etVasculaires, Plateforme Exercice Performance Santé Innovation, SFR FED 4234, Université deFranche--Comté, Besançon, France - - - 2014
The purpose was to examine the changes in femoral artery blood flow during cold water immersion (CWI), contrast water therapy (CWT) and thermoneutral water immersion (TWI). Ten athletes came to the laboratory three times, to complete a 20--min procedure in upright position: 4 min in air (baseline) then 16--min full ...
Mitterlechner Thomas T Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, - - 2014
In preoxygenated patients, time until oxygen saturation drops can be extended by insufflating oxygen into their airways, thus oxygenating them apneically. To compare different methods of apneic oxygenation. A noncommercial dual-use laryngoscope with an internal lumen in its blade was used to provide oxygen insufflation into a simulated laryngeal space ...
Frat Jean-Pierre JP Réanimation Médicale, and Institut National de la Santé et de la Recherche Médicale, CIC-1402, Université de Poitiers, Poitiers, France. - - 2014
The aim of this study was to evaluate the clinical efficacy of humidified oxygen via high-flow nasal cannula (HFNC) alternating with noninvasive ventilation (NIV) in acute hypoxemic respiratory failure (AHRF). We performed a prospective observational study in a 12-bed ICU of a university hospital. All subjects with a PaO2 /FIO2 ...
Sotello David D Texas Tech University Health Sciences Center, Lubbock, - - 2014
: High-flow nasal cannula oxygen (HFNC) is a relatively new therapeutic innovation being used in adults with severe respiratory disease. It delivers heated humidified oxygen through short nasal prongs and supplies much higher flow rates than traditional nasal cannula systems. These higher flows match patient flow demands better, reduce anatomic ...
Li Zhiqing Z Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110001, People's Republic of - - 2014
We aimed to investigate the blood brain barrier (BBB) change caused by subarachnoid hemorrhage (SAH) and to explore the molecular mechanisms of acute brain injury after SAH. The SD rat model of SAH was firstly established by endovascular filament perforation technique. The changes of regional cerebral blood flow (rCBF), BBB ...
Ishiguro Akio A Department of Pediatrics, Division of Neonatal Medicine, Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, - - 2014
Septic shock is associated with impaired vasoregulation, and treatment includes vasoactive drugs. Therefore, evaluation of vasoregulatory change is important. The present report describes the successful characterization of vasoregulatory change in response to a vasoactive drug during septic shock. A male infant born at 23 weeks' gestation developed septic shock. Severe ...
Vinay Byrappa B Department of Neuroanaesthesia, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, - - 2014
Following an episode of reduction in inspired oxygen concentration (FiO2) and inhalational agent concentration (Fi agent) during the changing of a soda lime absorber, We conducted an in vitro experiment to understand the impact of disconnection of the absorber on inspired gas dilution at different fresh gas flows. We found ...
Brennan Martin D MD UIC Bioengineering (MC 563), 820 S Wood St W103 CSN, Chicago, IL 60612, USA. - - 2014
Cellular function and behavior are affected by the partial pressure of O2, or oxygen tension, in the microenvironment. The level of oxygenation is important, as it is a balance of oxygen availability and oxygen consumption that is necessary to maintain normoxia. Changes in oxygen tension, from above physiological oxygen tension ...
Spinelli Elena E University of Michigan Medical School, University of Michigan - ECMO Lab, 1150 W. Medical Center Drive, B560 MSRB II, Ann Arbor, MI - - 2014
During veno-venous extracorporeal membrane oxygenation (VV-ECMO) support, optimization of oxygenation can be achieved by therapeutic interventions on both patient physiological variables and adjustment of ECMO settings.Based on the physiology of oxygen delivery during VV-ECMO support, we established the mathematical relationship between the variables which define the oxygenation state: hemoglobin (Hb), ...
Palkovits Stefan S Medical University of - - 2014
Animal experiments indicate that the inner retina keeps its oxygen extraction constant despite systemic hypoxia. For the human retina no such data exist. In the present study we hypothesized that systemic hypoxia does not alter inner retinal oxygen extraction. To test this hypothesis we included 30 healthy male and female ...
Bale Gemma G Department of Medical Physics and Bioengineering, Malet Place Engineering Building, University College London, - - 2014
We present a novel lens-based broadband near-infrared spectroscopy system to simultaneously measure cerebral changes in tissue oxygenation and haemodynamics via estimation of the changes in haemoglobin concentration; in addition to oxygen utilization via the measurement of the oxidation state of cytochrome-c-oxidase (CCO). We demonstrate the use of the system in ...
Temma Takashi T Department of Investigative Radiology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, - - 2014
Understanding cerebral oxygen metabolism is of great importance in both clinical diagnosis and animal experiments because oxygen is a fundamental source of brain energy and supports brain functional activities. Since small animals such as rats are widely used to study various diseases including cerebral ischemia, cerebrovascular diseases, and neurodegenerative diseases, ...
Rivaes Rui P RP Forest Research Center, Instituto Superior de Agronomia, Universidade de Lisboa, Lisbon, - - 2014
Global circulation models forecasts indicate a future temperature and rainfall pattern modification worldwide. Such phenomena will become particularly evident in Europe where climate modifications could be more severe than the average change at the global level. As such, river flow regimes are expected to change, with resultant impacts on aquatic ...
Joh Hea Min HM Department of Physics, Dong-A University, Busan 604-714, Republic of - - 2014
The atmospheric pressure helium plasma jet driven by pulsed dc voltage was utilized to treat human lung cancer cells in vitro. The properties of plasma plume were adjusted by the injection type and flow rate of additive oxygen gas in atmospheric pressure helium plasma jet. The plasma characteristics such as ...
Tsai Amy G AG Department of Bioengineering, University of California, San Diego (UCSD), La Jolla, CA 92093, USA. - - 2014
At least a third of the blood supply in the world is used to transfuse 1-2 units of packed red blood cells for each intervention and most clinical trials of blood substitutes have been carried out at this level of oxygen carrying capacity (OCC) restoration. However, the increase of oxygenation ...
Bouillot Pierre P Interventional Neuroradiology Unit, Service of Neuroradiology, University Hospital of Geneva, Genève, Switzerland; Laboratory for Hydraulic Machines, École Polytechnique Fédérale de Lausanne, Lausanne, - - 2014
We investigated the flow modifications induced by a large panel of commercial-off-the-shelf (COTS) intracranial stents in an idealized sidewall intracranial aneurysm (IA). Flow velocities in IA silicone model were assessed with and without stent implantation using particle imaging velocimetry (PIV). The use of the recently developed multi-time-lag method has allowed ...
Diab Sara S 0000-0003-4743-6787 Critical Care Research Group, Adult Intensive Care Service, The Prince Charles Hospital, Brisbane, QLD 4032, - - 2014
Bronchoscopy is an important diagnostic and therapeutic intervention for a variety of patients displaying pulmonary pathology. The heterogeneity of the patients undergoing bronchoscopy affords a challenge for providing minimal and safe respiratory support during anesthesia. Currently, options are intubation and general anesthesia versus frequently inadequate sedation or local anaesthesia with ...
Sakadžić Sava S Optics Division, MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, - - 2014
What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic imaging of intravascular O2 partial pressure and blood flow combined with numerical modelling. Here we show that parenchymal arterioles are ...
Banjo Toshihiro - - 2013
Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and morphogenesis are largely unknown. Here we use a zebrafish model to ...
Jamison R Aidan - - 2013
Physical forces can influence the embryonic development of many tissues. Within the cardiovascular system shear forces resulting from blood flow are known to be one of the regulatory signals that shape the developing heart. A key challenge in investigating the role of shear forces in cardiac development is the ability ...
Junker K - - 2012
Monanema joopi n. sp. is described from blood drawn from the heart of the murid Acomys (Acomys) spinosissimus in South Africa. It is characterised by a non-bulbous cephalic extremity, shared with only one of its five congeners, and a cylindrical tail with caudal alae and a spicular ratio of 2.7 ...
Knaut M - - 2012
Heart failure patients are clinically characterized by extreme cardiomegaly, breathlessness, fluid retention and an early onset of fatigue. Studies have shown generalized restricted blood flow in those patients. Furthermore animal experiments proved an impaired blood flow and a diminished oxygen supply of the skeletal muscle in animals with chronic heart ...
Leweke Thomas T Institut de Recherche sur les Phenomenes Hors Equilibre (IRPHE), 49 rue Frederic Joliot-Curie, Marseille Cedex 13, France. - - 2012
Flow visualization using dye is an inexpensive and easy-to-implement experimental technique. It can be used for a rapid qualitative assessment of fluid flows in configurations relevant to biomedical or biotechnological applications, which often involve small spatial dimensions and flow velocities (low Reynolds numbers). This paper gives an overview of the ...
Cuper Natascha J - - 2012
Obtaining access to blood vessels can be difficult, especially in children. Visualization of subsurface blood vessels might be a solution. Ultrasound and visible light have been used to this purpose, but have some drawbacks. Near-infrared light might be a better option since subsurface blood vessels can be visualized in high ...
Baert Barbara - - 2012
The textual and visual tradition of the story of the woman with the haemorrhage (Mark 5.24b-34parr), the so-called Haemorrhoissa, is related in a specific way to Christ's healing miracles but also to conceptions of female menstrual blood. We notice that with regard to the specific 'issue of blood' of the ...
Gabel Kristi T - - 2012
Accurate quantification of blood loss is an essential skill necessary to prevent maternal morbidity and mortality associated with obstetric hemorrhage. Visual estimation of blood has been consistently shown to be extremely inaccurate. The nurse plays a pivotal role in quantifying blood loss after birth, recognizing triggers, mobilizing needed interventions, and ...
Baena-Díaz F - - 2012
Although the spatial separation of sexual organs within a flower (herkogamy) has been interpreted as a mechanism that promotes efficient pollen transfer, there have been few attempts to relate variation in herkogamy to probabilities of pollen flow. Here, we used a heterostylous species with variation in reciprocal herkogamy to test ...
Wilga Cheryl D - - 2012
Fluid flow generated by body movements is a foraging tactic that has been exploited by many benthic species. In this study, the kinematics and hydrodynamics of prey handling behavior in little skates, Leucoraja erinacea, and round stingrays, Urobatis halleri, are compared using kinematics and particle image velocimetry. Both species use ...
Clapp Carmen - - 2012
The hormone prolactin (PRL), fundamental for lactation in mammals, is known to exert a wide diversity of actions in the various vertebrate groups. Blood vessels are surfacing as important PRL targets, contributing to these hormonal functions. PRL promotes the growth of new blood vessels (angiogenesis) and is proteolytically cleaved to ...
Stone Chris M - - 2012
The purpose of this study was to determine whether the sugar-or-blood meal choice of Anopheles gambiae females one day after emergence is influenced by blood-host presence and accessibility, nectariferous plant abundance, and female size. This tested the hypothesis that the initial meal of female An. gambiae is sugar, even when ...
Lahondère Chloé - - 2011
Temperature is one of the most important factors affecting the life of insects [1]. For instance, high temperatures can have deleterious effects on insects' physiology. Therefore, many of them have developed various strategies to avoid the risk of thermal stress [2]. They can seek a fresher environment or adjust their ...
Teal Allen E - - 2012
Babesiosis is an emerging zoonosis with important public health implications, as the incidence of the disease has risen dramatically over the past decade. Because the current gold standard for detection of Babesia is microscopic examination of blood smears, accurate identification requires trained personnel. Species in the genus cannot be distinguished ...
Shimada Yutaka - - 2011
BACKGROUND: Adequate blood supply for the reconstructed organ is important for safe esophagogastric anastomosis during esophagectomy. Recently, indocyanine green (ICG) has been used for visualization of the blood supply when anastomosis is performed in vascular surgery. To visualize the blood supply for reconstruction, we employed ICG fluorescence during esophagectomy. METHODS: ...
Müller Günter C - - 2011
The horse fly fauna (Diptera: Tabanidae) of Jordan is, after Israel, the richest in the Levant, with 24 known species. During the 20-year project "The Ecology and Zoogeography of the Lepidoptera of the Near East," we regularly collected blood-feeding flies, resulting in 11 additional species of Tabanidae for Jordan. The ...
Stewart-Koster B - - 2011
In this study, relationships between flow variation across multiple temporal scales and the distribution and abundance of three fish species, western rainbowfish Melanotaenia australis, sooty grunter Hephaestus fuliginosus and barramundi Lates calcarifer were examined at eight sampling reaches in the Daly River, Northern Territory, Australia. Discharge was highly seasonal during ...
Goldenheim William M - - 2011
To test for threshold effects in the response of coral physiology to increasing seawater flow, field and laboratory experiments were conducted in Moorea. First, the growth of juvenile massive Porites spp. and branching P. irregularis was compared among habitats differing in water motion. Growth of massive Porites spp. responded to ...
Verbeek Kevin - - 2011
Flow maps are thematic maps that visualize the movement of objects, such as people or goods, between geographic regions. One or more sources are connected to several targets by lines whose thickness corresponds to the amount of flow between a source and a target. Good flow maps reduce visual clutter ...
Wallace Jim - - 2011
Much of the sediment and nutrient load to the Great Barrier Reef (GBR) lagoon happens during over bank floods, when discharge can be significantly underestimated by standard river gauges. This paper assesses the potential need for a flood load correction for 28 coastal rivers that discharge into the GBR lagoon. ...
Urbina Mauricio A - - 2011
How fish oxygen consumption is modulated by external PO(2) has long been a matter of interest, yet is an experimentally complicated question to answer. In this study closed and semi-closed respirometry were used to evaluate the oxygen consumption rate of the scaleless galaxiid fish, inanga (Galaxias maculatus) as a function ...
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