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Crystal George J GJ Department of Anesthesiology, Advocate Illinois Masonic Medical Center, 836 West Wellington Avenue, Chicago, IL 60657, USA. - - 2014
Fractional flow reserve (FFR) is a physiological index of the severity of a stenosis in an epicardial coronary artery, based on the pressure differential across the stenosis. Clinicians are increasingly relying on this method because it is independent of baseline flow, relatively simple, and cost effective. The accurate measurement of ...
Wagner Peter D PD Dept of Medicine, University of California, San Diego, La Jolla, CA, USA - - 2014
The field of pulmonary gas exchange is mature, with the basic principles developed more than 60 years ago. Arterial blood gas measurements (tensions and concentrations of O2 and CO2) constitute a mainstay of clinical care to assess the degree of pulmonary gas exchange abnormality. However, the factors that dictate arterial ...
Scott Jacob G JG Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; Wolfson Centre for Mathematical Biology, Mathematical Institute, Radcliffe Observatory Quarter, University of Oxford, Woodstock Road, Oxford OX2 6GG, - - 2014
Research into mechanisms of haematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of 'seed-soil' relationships. Preceding this biological mechanism is the physical process of dissemination of circulating tumour cells (CTCs) in the circulation. Patterns of metastatic spread have been previously quantified using the metastatic ...
Kwak Brenda R BR Department of Pathology and Immunology, University of Geneva, CMU, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland brenda.kwakchanson@unige.ch - - 2014
Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall (radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress). The stresses and strains experienced by arteries influence the initiation of atherosclerotic lesions, which develop at regions of arteries that are exposed to ...
Brace Robert A RA OHSU - - 2014
Experimentation in late gestation fetal sheep has suggested that regulation of amniotic fluid (AF) volume occurs primarily by modulating the rate of intramembranous transport of water and solutes across the amnion into underlying fetal blood vessels. In order to gain insight into intramembranous transport mechanisms, we developed a computer model ...
Herault J J Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, Université Pierre et Marie Curie and Université Paris Diderot, Paris, - - 2014
We consider a fluid dynamo model generated by the flow on both sides of a moving layer. The magnetic permeability of the layer is larger than that of the flow. We show that there exists an optimum value of magnetic permeability for which the critical magnetic Reynolds number for dynamo ...
Jackson Jesse J 1] Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, Québec, Canada. [2] Present address: Department of Biological Sciences, Columbia University, New York, New York, - - 2014
Activity flow through the hippocampus is thought to arise exclusively from unidirectional excitatory synaptic signaling from CA3 to CA1 to the subiculum. Theta rhythms are important for hippocampal synchronization during episodic memory processing; thus, it is assumed that theta rhythms follow these excitatory feedforward circuits. To the contrary, we found ...
Caldwell Joanne N JN Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW 2522, - - 2014
The purpose of this project was to design, construct and validate water-displacement plethysmographs for the forearm, hand and foot that could clamp segmental skin temperature whilst simultaneously measuring cutaneous blood flow. Two experiments were performed. In the first, the forearm plethysmograph was validated against a mercury-in-silastic plethysmograph under thermoneutral conditions, ...
Müller Lucas O LO Laboratory of Applied Mathematics, University of Trento, Via Mesiano 77, 38123 Trento, Italy. Electronic address: - - 2014
Here we extend the global, closed-loop, mathematical model for the cardiovascular system in Müller and Toro (2014) to account for fundamental mechanisms affecting cerebral venous haemodynamics: the interaction between intracranial pressure and cerebral vasculature and the Starling-resistor like behaviour of intracranial veins. Computational results are compared with flow measurements obtained ...
Alshryda S S Central Manchester Hospitals, Oxford Road, Manchester, M13 9WL, - - 2014
Intravenous tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after joint replacement. Recently, there has been interest in applying it topically before the closure of surgical wounds. This has the advantages of ease of application, maximum concentration at the site ...
Hisamitsu Tadashi T Department of Physiology, School of Medicine, Showa University, Tokyo, Japan. Electronic address: - - 2014
In Oriental medicine, the state of blood stagnation is called "Oketsu," meaning preceding state or symptomatic of sickness. Acupuncture stimulation is often used clinically for the treatment of "Oketsu." The degree of "Oketsu" is indicated by tongue color and form, swelling, paroxysmal blushing, and dark circles under the eyes. The ...
Gandini R R Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology, Radiotherapy,and Nuclear Medicine, ''IRCCS Policlinico di Tor Vergata,'' Rome, Italy - - - 2014
Endovascular and subintimal approaches fails in obtaining a below--the--knee recanalization in 10--40% of cases, even in high--volume and expertise centers. The presence of long calcified occlusions, characterized by a complex anatomy, often necessitate the use of alternative techniques in order to obtain a direct blood flow to the foot arteries. ...
Gómez-Lesmes Sandra P SP Department of Internal Medicine, University Hospital of Salamanca-IBSAL, Salamanca, - - 2014
The aim of our study was to determine the potential influence of blood transfusion and the length of storage of packed red blood cells (RBC) on prosthetic joint infection after primary knee arthroplasty. From November 2007 to November 2009, all variables potentially associated with deep infection were registered in 1331 ...
Allan Georgina H GH University of Adelaide, - - 2014
Nutrient arteries enter limb bones through discrete foramina on the shafts. They are required for bone remodelling in response to mechanical loading and dynamic forces imposed by locomotion. The cross-sectional area of the nutrient foramen of the femur represents an index of blood flow rate to the shaft and thus ...
Caldwell Joanne N JN Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW, 2522, - - 2014
Much is known about the control of blood flow, yet gaps remain concerning the interactions of deep-body and peripheral thermal feedback. In this experiment, changes in the vascular tone of the hands and feet were mapped to demonstrate the separate and combined influences of mean body and local skin temperature changes. ...
Yoshihara Hiroyuki H Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York; Department of Orthopaedic Surgery, SUNY Downstate Medical Center, Brooklyn, New - - 2014
We examined the predictors of allogeneic blood transfusion (ALBT) in primary unilateral total hip arthroplasty (THA) and total knee arthroplasty (TKA), analyzing the Nationwide Inpatient Sample between 2000 and 2009. Multivariate logistic regression analysis was performed. Significant predictors of ALBT in both THA and TKA included older age, female gender, ...
Yoshihara Hiroyuki H Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York; Department of Orthopaedic Surgery, SUNY Downstate Medical Center, Brooklyn, New - - 2014
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are among the most common surgical procedures that necessitate blood transfusion. The purpose of this study was to examine the trends in the utilization of blood transfusions in THA and TKA in the US from 2000 to 2009 by analyzing the ...
George D A DA Department of Trauma and Orthopaedics, Barnet Hospital, Wellhouse Lane, Barnet, EN5 3DJ, UK, - - 2014
Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin. It has been shown to reduce blood loss in trauma and other haemorrhagic conditions and has recently been utilised in elective orthopaedic surgery. There are various methods of administering TXA described in the literature. ...
Durrani Salim K SK Institute of Orthopedic Research and - - 2014
Background and purpose - In patients with metal-on-metal (MoM) hip prostheses, pain and joint effusions may be associated with elevated blood levels of cobalt and chromium ions. Since little is known about the kinetics of metal ion clearance from the body and the rate of resolution of elevated blood ion ...
Hendrickson E H S EH Norwegian School of Veterinary Science, Department of Companion Animal Clinical Sciences, P.O. Box 8146 Dep., 0033 Oslo, - - 2014
To increase understanding of why the prevalence of clinical/radiographic osteochondrosis dissecans is high in horses and low in ponies. To investigate whether the clinical difference in OC occurrence between horses and ponies could partly be explained by a difference in 1: Number of patent vessels in the epiphyseal growth cartilage. ...
Guirro Elaine Caldeira de Oliveira EC Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Medical School of Ribeirão Preto, University of São Paulo, - - 2014
[Purpose] The purpose of this study was to correlate the talocrural range of motion (ROM) and blood flow velocity in the lower limb arteries of diabetic women. [Subjects and Methods] Thirty women were divided into a control group (G1), consisting of 15 sedentary right-handed subjects (41.27 ± 7.24 years old) who ...
Thienpont Emmanuel E Department of Orthopedic Surgery, Cliniques Universitaires Saint Luc, Av. Hippocrate 10, 1200, Brussels, Belgium, - - 2014
Blood loss can be substantial and will influence morbidity and mortality after total knee arthroplasty. This study evaluated whether patient-specific instruments (PSI) can reduce blood loss because the intramedullary canal is not opened during the procedure and whether hidden blood loss can be reduced by its use. Seventy-five patients operated ...
Waldstein Wenzel W Adult Reconstruction & Joint Replacement Division, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, - - 2014
Intact cartilage in the lateral compartment is an important requirement for medial unicompartmental knee arthroplasty (UKA). Progression of cartilage degeneration in the lateral compartment is a common failure mode of medial UKA. Little is known about factors that influence the mechanical properties of lateral compartment cartilage. The purposes of this ...
Chen Jerry Yongqiang JY Department of Orthopaedic Surgery, Singapore General Hospital, Outram Road, Academia Building Level 4, Singapore, 169608, Singapore, - - 2014
The use of tourniquet in total knee arthroplasty (TKA) has resulted in negligible intra-operative blood loss but notable post-operative blood loss, creating the ideal scenario for using topical haemostatic agents intra-operatively. Recently, medical adjuvants including tranexamic acid (TXA) and hydrogen peroxide (H2O2) have been introduced. The aim of this study ...
Singh Deepika D Buchmann Institute for Molecular Life Sciences, Institute of Biochemistry II, Goethe University, Max-von-Laue-Strasse 15, 60438 Frankfurt (Main), - - 2014
Cortical flows mediate anteroposterior polarization in Caenorhabditis elegans by generating two mutually exclusive membrane domains. However, factors downstream of anteroposterior polarity that establish the dorsoventral axis remain elusive. Here, we show that rotational cortical flow orthogonal to the anteroposterior axis during the division of the AB blastomere in the two-cell ...
Loomis John J Department of Agricultural and Resource Economics, Colorado State University, Fort Collins, CO, 80523-1172, USA, - - 2014
Whitewater river kayaking and river rafting require adequate instream flows that are often adversely affected by upstream water diversions. However, there are very few studies in the USA of the economic value of instream flow to inform environmental managers. This study estimates the economic value of instream flow to non-commercial ...
Valignat Marie-Pierre MP 1] Laboratory Adhesion &Inflammation, Aix Marseille Université, LAI UM 61, Marseille F-13288, France [2] Inserm, UMR_S 1067, Marseille F-13288, France [3] CNRS, UMR 7333, Marseille F-13288, - - 2014
A wide variety of cells migrate directionally in response to chemical or mechanical cues, however the mechanisms involved in cue detection and translation into directed movement are debatable. Here we investigate a model of lymphocyte migration on the inner surface of blood vessels. Cells orient their migration against fluid flow, ...
Schneider Marco M MM Orthopaedic Surgery, Helios ENDO-Klinik, Hamburg, Germany Department of Orthopaedic Surgery, Traumatology and Sports Medicine, Cologne Merheim Medical Center, Witten/Herdecke University, Witten, - - 2013
Autologous transfusion has become a cost-efficient and useful option in treatment patients with high blood loss following major orthopaedic surgery. However, the effectiveness of autologous transfusion in total joint replacement remains controversial.OBJECTIVE: The current study analyzed the efficacy of autologous transfusion with washed shed blood (WSB) in primary total knee ...
Greenky Max M Rothman Institute of Orthopaedics, Thomas Jefferson University, Philadelphia, - - 2013
The purpose of the present study was to identify factors that predict reinfusion following intraoperative blood salvage (IOBS). We retrospectively identified 298 patients who underwent aseptic revision total hip arthroplasty at our institution between February 2005 and January 2007. Of these, 160 (53.7%) received reinfusion from IOBS. In the reinfusion ...
Finley James M JM University of Southern - - 2013
Visual input provides vital information for helping us modify our walking pattern. For example, artificial optic flow can drive changes in step length during locomotion and may also be useful for augmenting locomotor training for individuals with gait asymmetries. Here, we asked whether optic flow could modify the acquisition of ...
Kagaya Y Y Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Japan. Electronic address: - - 2013
The "tissue oxygen saturation (StO2) foot-mapping" method was developed using a non-invasive near-infrared tissue oximeter monitor to classify the foot regions as ischemic and non-ischemic areas. The purpose of this study was to evaluate StO2 foot-mapping as a reliable method to detect ischemic areas in the feet of patients with ...
Struijk-Mulder M C - - 2013
Hip and knee arthroplasties are frequently complicated by the need for allogeneic blood transfusions. This survey was conducted to assess the current use of perioperative blood-saving measures and to compare it with prior results. All departments of orthopaedic surgery at Dutch hospitals were sent a follow-up survey on perioperative blood-saving ...
Boyaci Ahmet - - 2013
To investigate whether blood flow in the lower extremity arteries changes in patients with osteoarthritis (OA) using color Doppler ultrasonography. The study comprised 39 female patients with osteoarthritis and 30 healthy female controls. The patients were evaluated using visual analogue scale (VAS) at rest and the Western Ontario and McMaster ...
Gurtler Volker - - 2013
In order to determine the effect of the increase in sensitivity of HCMV detection in whole blood compared to plasma on reproductive rate (Ro) measurement, an optimized Human cytomegalovirus (HCMV) quantitative PCR assay was developed. The results presented in this study are summarized by the following three methodological improvements: (i) ...
Alshryda Sattar - - 2013
Approximately one-third of patients undergoing total knee replacement require one to three units of blood postoperatively. Tranexamic acid (TXA) is a synthetic antifibrinolytic agent that has been successfully used intravenously to stop bleeding after total knee replacement. A topical application is easy to administer, provides a maximum concentration of tranexamic ...
Faldini Cesare C General Orthopaedic Surgery, Rizzoli-Sicilia Department, Rizzoli Orthopaedic Institute, SS 113, km 246, 90011, Bagheria, PA, - - 2013
A consistent post-operative limb positioning regime could be an attractive, simple and cost-effective alternative to improve patient's outcomes after total knee arthroplasty (TKA). The aim of this study was to perform a systematic review of the available literature in order to understand whether a consistent post-operative limb positioning regime could ...
Kasmer Mark E - - 2013
Foot strike pattern has not been examined during ultramarathons where fatigue or avoidance of impact might have greater affect on foot strike and other gait parameters than in shorter events. In this study, video analysis from three level sites at a 161-km ultramarathon was used to: (1) examine changes in ...
Fuhs Thomas - - 2013
Confronting motile cells with obstacles doubling as force sensors we tested the limits of the driving actin-and-myosin-machinery. We could directly measure the force necessary to stop actin polymerization as well as the force present in the retrograde actin flow. Combined with detailed measurements of the retrograde flow velocity and specific ...
Park Jai Hyung - - 2013
UPDATE The print version of this article has errors that have been corrected in the online version of this article. In the Materials and Methods section, the sentence that reads as "During the study period, our institution offered preoperative autologous blood donation to all patients who were scheduling for total ...
Antinolfi Pierluigi - - 2013
To compare the blood loss and the blood transfusion between a control group and a group of patients following either a local administration of tranexamic acid or a mechanical post-operative knee flexion, a controlled randomized study was performed. Sixty patients affected by primary knee osteoarthritis and candidates to receive a ...
Karam Joseph A - - 2013
Tranexamic acid (TA) has been reported to reduce blood loss after total joint arthroplasty; however, the literature is sparse in evaluating its efficacy in simultaneous bilateral total knee arthroplasty (TKA). In this retrospective study of consecutive patients, TA use in bilateral TKA was associated with a significant reduction in perioperative ...
Jousse-Joulin Sandrine - - 2013
Although tendon pain is commonly reported in primary Sjögren syndrome (pSS), the underlying mechanism is unknown. The objective of this study was to determine whether tendon pain in pSS is related to involvement of the tendons and entheses. We performed a physical examination of 288 entheseal insertion sites in 16 ...
Yumatov E A - - 2013
The external long-distance manifestations of the subjective status of a human being are analyzed. The subjective states of a human being can be objectively recorded at a long distance. A contact-free long-distance effect of human subjective status on the physicochemical parameters of the blood is demonstrated. The concept of the ...
Ogbemudia Ann E - - 2013
INTRODUCTION: To identify the preoperative predictors of requirement for postoperative allogenic blood transfusion following hip and knee joint arthroplasty. MATERIALS AND METHODS: We analysed the retrospective data on patients with rheumatoid arthritis who had undergone either total hip or knee arthroplasty at a single university teaching hospital. Factors of age, ...
Liu Qinghua - - 2013
An experimental method for measurement of local redox potential within multilayer electrodes was developed and applied to all-vanadium redox flow batteries (VRFBs). Through-plane measurement at the positive side reveals several important phenomena including potential distribution, concentration distribution of active species and the predominant reaction location within the porous carbon electrodes.
Akanyeti Otar O The Whitney Laboratory for Marine Bioscience, Department of Biology, University of Florida, 9505 Ocean Shore Blvd, St Augustine, FL 32080-8610, - - 2013
We have little understanding of how fish hold station in unsteady flows. Here, we investigated the effect of flow speed and body size on the kinematics of rainbow trout Kármán gaiting behind a 5 cm diameter cylinder. We established a set of criteria revealing that not all fish positioned in ...
Rocha Luis E C - - 2013
Networks are commonly used to define underlying interaction structures where infections, information, or other quantities may spread. Although the standard approach has been to aggregate all links into a static structure, some studies have shown that the time order in which the links are established may alter the dynamics of ...
Craik Johnathan D - - 2013
Blood transfusions are frequently required following total knee arthroplasty. Tranexamic acid (TXA) inhibits fibrinolysis and has been shown to reduce blood loss and transfusion requirements when delivered intravenously. Topical and intra-articular applications directly target bleeding sites whilst limiting systemic uptake and theoretically reduce the risk of thromboembolic complications. However, in ...
Voges Inga - - 2013
OBJECTIVES: In patients after completion of the total cavopulmonary connection (TCPC) with an intra-atrial lateral tunnel, deviations of the tunnel from an ideal straight tubular shape were observed. However, little is known about frequency and adverse effects of such shape deviations. We sought to analyse tunnel anatomy, dimensions and blood ...
van Meegeren Monique E R - - 2013
Objective. IL-4 plus IL-10 prevents blood-induced cartilage damage. The aim of the present study was to evaluate whether cartilage damage can still be averted by addition of IL-4 plus IL-10 when added after the onset of a bleed and whether aspiration of blood prior to addition of IL-4 plus IL-10 ...
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