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Guo Ying-Jun YJ Department of Orthopaedic Surgery, Qilu Hospital of Shandong University, Jinan 250012, - - 2014
To evaluate whether the self-blood has influence on the molding process of polymethyl methacrylate (PMMA) bone cement, and to make sure whether it is valuable for the clinical practice. An in vitro study was performed to evaluate the prolonging-effect of self-blood on PMMA bone cement. The effect of prolonging was ...
Abraham Michael H MH Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. Electronic address: - - 2014
A simple method is reported for the estimation of in vivo air-tissue partition coefficients of VOCs and of in vitro blood-tissue partition coefficients for volatile organic compounds and other compounds. Linear free energy relationships for tissues such as brain, muscle, liver, lung, kidney, heart, skin and fat are available and ...
Kato Hiroshi H *Departments of Geriatric and Environmental Dermatology; †Neuro-otolaryngology, Nagoya City University Graduate School of Medical Sciences, Nagoya, - - 2014
The external auditory canal is one of the most difficult sites to reconstruct after tumor resection. In general, fascia transplantation is used to reconstruct defects of the external auditory canal, but this method is associated with scar formation and prolonged wound healing. Scar tissue might cause stenosis in the external ...
Sørensen Mette A MA Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Taastrup, - - 2014
As in other fibroproliferative disorders, hypoxia has been suggested to play a key role in the pathogenesis of exuberant granulation tissue (EGT). The purpose of this study was to investigate metabolism and blood flow locally in full-thickness wounds healing with (limb wounds) and without (body wounds) formation of EGT.Microdialysis was ...
Kato Hiroshi H *Departments of Geriatric and Environmental Dermatology; †Neuro-otolaryngology, Nagoya City University Graduate School of Medical Sciences, Nagoya, - - 2014
The external auditory canal is one of the most difficult sites to reconstruct after tumor resection. In general, fascia transplantation is used to reconstruct defects of the external auditory canal, but this method is associated with scar formation and prolonged wound healing. Scar tissue might cause stenosis in the external ...
Hawi Nael N Department of Orthopaedic Surgery, Helios ENDO-Klinik, Holstenstr. 2, 22767, Hamburg, Germany, - - 2014
The goal of this study was to analyse the efficacy of blood autotransfusion using a continuous autologous transfusion system in revisions of total hip arthroplasty (THA). We looked at whether administration of allogeneic blood units was reduced in these cases and if there is a difference between cemented and non-cemented ...
Behinaein Sepideh S Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada. - - 2014
The overwhelming proportion of the mass of lead (Pb) is stored in bone and the residence time of Pb in bone is much longer than that in other tissues. Hence, in a metabolic model that we used to solve the differential equations governing the transfer of lead between body compartments, ...
Sánchez-Muñoz Laura L Mastocytosis Unit of Castilla La-Mancha, Hospital Virgen del Valle, Toledo, Spain; Spanish Network on Mastocytosis (REMA), Toledo, Spain. Electronic address: - - 2014
This article presents information for the identification and characterization of mast cells from bone marrow and other tissues using multiparametric flow cytometry. In addition, it provides guidelines for the application of this technique in the subclassification of systemic mastocytosis and assessment of the long-term prognosis of patients individually.
Freire Vanesa V *Department of Cell Biology and Histology, School of Medicine and Dentistry, BioCruces Health Research Institute, University of the Basque Country, Leioa, Spain; †Department of R&D, Instituto Clínico-Quirúrgico de Oftalmología, Bilbao, Spain; ‡BioCruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain; and §Department of Ophthalmology, School of Medicine and Dentistry, BioCruces Health Research Institute, University of the Basque Country, Leioa, - - 2014
The aim of this study was to compare the effect on corneal wound healing of 3 differently manufactured blood derivatives [autologous serum (AS), platelet-rich plasma, and serum derived from plasma rich in growth factors (s-PRGF)]. Scratch wound-healing assays were performed on rabbit primary corneal epithelial cultures and human corneal epithelial ...
Chaikeeratisak Vorrapon V Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California - - 2014
In addition to its roles in hemostasis and wound repair, the blood clot plays an underappreciated role in innate immunity, where the established clot serves as a barrier to microbial penetration into the internal milieu and where the early clot entraps and immobilizes microbes that have entered wounds to the ...
Teunissen Marcel B M MB Department of - - 2014
Innate lymphoid cells (ILC) are increasingly appreciated as important regulators of tissue homeostasis and inflammation. However, their role in human skin remains obscure. We found that healthy peripheral blood CD117(+) ILC3, lacking the natural cytotoxicity receptor (NCR) NKp44 (NCR(-) ILC3), CD117(-)NCR(-)CRTH2(-)CD161(+) ILC1 and CRTH2(+) ILC2 express the skin-homing receptor cutaneous ...
Mottet Kelly K From Innovative Trauma Care, Inc. (K.M., D.F., I.A.), Edmonton, Alberta; and Department of Surgery, Faculty of Medicine, University of Manitoba (S.L.), Winnipeg, Manitoba, - - 2014
Uncontrolled hemorrhage is a significant cause of preventable death. The iTClamp 50 is a temporary wound closure device designed to control bleeding within seconds of an injury. This study evaluates the ability of the iTClamp to control compressible bleeding in a human cadaver model. Sterile water was pumped through the ...
Park Sunita I SI Children's Healthcare of Atlanta, 1405 Clifton Road, NE, Egleston Children's Hospital, Department of Pathology, First Floor, Tower One, Atlanta, GA 30322, - - 2014
ABSTRACT B-lymphoblastic leukemia/lymphoma (B-LL) is the most common childhood cancer. Circulating blasts in the peripheral blood may be rare (≤1%) and missed, even when flow cytometric immunophenotyping is performed, leading to a false-negative report. The records from all patients with a new diagnosis of B-LL between January 2009 and December ...
Xia Cheng-Yan CY Department of Micro‑Orthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. - - 2014
Angiogenesis is involved in the wound healing process. Increased angiogenesis and blood flow constitute a major mechanism of negative pressure wound therapy (NPWT), which has been shown to facilitate the healing of infected wounds. However, the effect on the expression of angiogensis‑related growth factor remains unknown. The goal of the ...
Friedman Richard R Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston Orthopaedic Associates, 1012 Physicians Drive, Charleston, SC 29414. E-mail address: - - 2014
Up to 70% of patients who undergo total hip or total knee arthroplasty receive blood transfusions. Using data from more than 12,000 patients assessed in the Phase-III RECORD (Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Venous Thrombosis and Pulmonary Embolism) studies, we investigated whether allogeneic blood transfusion increases ...
Hoffmann Douglas G DG Dept of Pathology, Wellstar Kennestone Hospital, 677 Church St, Marietta, GA 30060; - - 2014
Objectives: To determine the clinical and financial impact and predictive value of a limited flow cytometry strategy in the evaluation of bone marrow specimens. Methods: Consecutive bone marrow cases (n = 1,242) were reviewed following the independent, prospective application of two flow cytometry protocols: a limited marker strategy and a ...
Seki Tadahiko T Department of Emergency and Critical Care Medicine, Nara Medical University Nara, - - 2014
The burn severity depends on the wound depth and area affected. Hitherto burn depth has been judged mainly by visual observation, although concerns have been raised about its validity. The regional tissue blood flow (rTBF) measured by laser Doppler imaging (LDI) in damaged tissue correlates with the depth. However, very ...
Altintas A A - - 2014
Splint immobilization of the forearm is often performed in clinical practice. Previous studies investigated the effect of immobilization on bone, cartilage, muscle, and tendon, however, the acute effects on human skin microcirculation and histomorphology remains elusive. In 12 healthy, nonsmoking individuals (aged 29.7 ± 9.1 years) a randomly selected forearm was immobilized ...
Zhang Wei W Zhanjiang Normal University, Round Beibu Gulf Institute for the Protection and Utilization of Marine Animals in Medicine, Zhanjiang 524048, China. - - 2014
Chitin and sepia ink hybrid hemostatic sponge (CTSH sponge), a new biomedical material, was extensively studied for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CTSH sponge in the blood system are lacking. This experiment aimed to examine whether CTSH sponge has ...
Rohleder Nils H NH Department of Oral and Maxillofacial Surgery, Technische Universität München, Munich, - - 2013
Microcirculation and oxygen supply in cervical skin were measured with an optical, noninvasive method in patients with or without radiotherapy before neck dissection. The course of wound healing was monitored after the surgical procedure to identify predictive factors for postoperative wound healing disorders. Tissue spectrophotometry and laser Doppler flowmetry were ...
Badgujar Shamkant B - - 2013
Latices from several plant species of Euphorbiaceae family have been traditionally applied over fresh cuts to stop bleeding and subsequently applied over wounds to enhance healing process. The latex arrested bleeding from fresh wounds by reducing bleeding and whole blood coagulation time which are important indices of haemostatic activity. It ...
Zheng Jianqiao J Jianqiao Zheng, MD, Department of Anesthesiology, West China Hospital of Sichuan University, No. 37, Guo Xue Alley, Chengdu 610041, Sichuan, - - 2013
A 35-year-old man was scheduled for dural arteriovenous fistula resection for vascular malformation under general anesthesia and a cell saver device was employed. The patient suffered from massive bleeding for the rupture of arteriovenous malformations from the beginning of the operation and 1000 mL cell-saved blood was transfused. After autologous ...
Barsun Alura - - 2013
Anemia is a complication of severe burn injury. Burn patients who refuse blood transfusions, such as Jehovah's Witnesses, present difficult challenges, and treatment paradigms need to be altered to reduce blood loss and increase red cell restoration. In this report the authors present a case of a 36-year-old Jehovah's Witness ...
Gilbert Emily A B - - 2013
Abstract Caudal autotomy-the ability to self-detach the tail-is a dramatic adaptation common to many structural-grade lizards. For most species, tail loss is followed by the equally dramatic phenomenon of tail regeneration. Here we review the anatomy and histology of caudal autotomy and regeneration in lizards, drawing heavily from research published ...
Petersen Lars J - - 2013
Laser Doppler imaging (LDI) and laser Doppler flowmetry (LDF) can measure localized skin perfusion. The purpose of the study was to directly compare LDF with LDI as a tool for measuring skin blood changes in an experimental model of chemically-induced skin inflammation. Regions of interest 1.8 cm(2) in area on the ...
Irandoust Shabnum - - 2013
A 29-year-old sheep shearer collapsed after walking across a shearing shed floor, holding his hand over an incised wound to his neck. Attempted resuscitation was unsuccessful. At the death scene fine arterial blood spatter was noted and at autopsy a single incised wound to the neck was observed, the patterned ...
Brodmann M - - 2013
Below-the-knee (BTK) disease with the clinical presentation of critical limb ischemia is associated with a high rate of limb loss due to minor and major amputations. The main problem is to find a way to optimize blood flow to the critical limb area. BTK joint the down-stream diverges into 3 ...
Abraham Michael H - - 2013
There is considerable interest in blood-tissue distribution of agrochemicals and a number of workers have developed experimental methods for in vitro distribution. These methods involve the determination of saline-blood and saline-tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution. We set out ...
Bhatnagar Monica - - 2014
Rapid initiation of clotting is critical to trauma patients. In the present study exopolymers (EPs) from four desert cyanobacteria including Tolypothrix tenuis and three species of Anabaena have been discovered as potential hemostatic biomaterials. The EPs showed reduction in activated partial thromboplastin time (APTT) and prothrombin time (PT) by 16-41% ...
Filips Dennis - - 2013
Abstract Objective. Severe hemorrhage is a leading cause of death and difficult to control even by trained medical personnel. Current interventions have significant limitations in the prehospital setting; therefore, a need exists for a new and effective treatment. iTraumaCare has designed a temporary wound closure device, the iTClamp, which controls ...
Chen Shuang Y - - 2013
Abstract Background/objectives: Dimethyl sulfoxide (DMSO) has been suggested as a traditional chemical probe for assessing skin susceptibility and barrier function. The purpose of this study was to determine the role of DMSO test for the evaluation of unusual skin angioneurotic reaction and epidermal permeability. Methods: Thirty healthy volunteers were exposed ...
Li Xu - - 2013
Although tourniquets are widely used in total knee arthroplasty (TKA), the effectiveness and safety are still in controversy. We therefore conducted an updated meta-analysis to compare the outcomes of tourniquet-assisted to non-tourniquet-assisted TKA and provide recommendations for using tourniquet in TKA. A systematic search of studies published through March 2013 ...
Brazio Philip S - - 2013
T regulatory cells (Tregs) have been associated with prolonged allograft survival and tolerance across a wide variety of species and organ types. We used our nonhuman primate model of facial vascularized composite allotransplantation (VCA) to study the association of Tregs with graft outcomes. We quantified Tregs in peripheral blood and ...
Kantola Rosita - - 2013
Abstract Objective. Glass-fiber reinforced composite has been suggested to be used as framework material in silicone elastomer facial prostheses. The glass-fiber reinforced framework makes it possible to make the margin of the prosthesis very tight, so that it will lean tightly against the skin even during facial expressions and jaw ...
Park Sunita Iyengar - - 2013
Abstract Background: B-lymphoblastic leukemia/lymphoma (B-LL) is the most common childhood cancer. Occasionally, circulating blasts in the peripheral blood are rare ({less than or equal to}1%) and may be missed, even when flow cytometric immunophenotyping is performed, leading to a false negative report. Methods: The records from all patients with a ...
Manivannan N - - 2013
The main prerequisites of any surgical procedure are achievement of good visibility and access to the site with minimal bleeding and rapid and painless healing. With the advancement of technology the armamentarium for oral surgical procedures has also widened. The use of alternate methods to the traditional scalpel such as ...
Igaki M - - 2013
PURPOSE: We analyzed skin heat conduction under moist and dry heat conditions to confirm the influence of moist heat on the skin and subcutaneous region. METHODS: Six healthy subjects placed their forearms in moist and dry heat air chambers, and the thickness of and moisture levels in the stratum corneum ...
Perotti Cesare - - 2013
Critical Limb Ischemia (CLI) is burdened by a 40% major amputation rate, and 5-year life expectancy <50%. We report the first-in-human injection of lethally -irradiated non HLA-matched cord blood-derived mononuclear cells in a no-option CLI patient, to induce therapeutic neo-angiogenesis, with evidence of successful outcome supported by clinical findings (ulcer ...
Canguven Onder - - 2013
Ischemic priapism, a compartment syndrome, requires urgent treatment in order to nourish the corpora cavernosa. As the first step, aspiration of blood and irrigation of the cavernosal bodies is performed to prevent fibrotic activity and secure erectile capability. During aspiration, there are risks of cardiovascular side effects of adrenergic agonists. ...
Lindstedt Sandra - - 2013
To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were ...
Kusuma Sharat K - - 2013
Reducing blood loss during primary total knee arthroplasty (TKA) can improve outcomes by reducing transfusion requirements and wound complications. We examined the use of bovine thrombin to augment hemostasis during primary TKA. A double-blinded randomized trial was performed with 80 primary TKA patients. Half received intraarticular bovine thrombin at the ...
Kunio Nicholas R - - 2013
BACKGROUND: The purpose of this study was to compare standard gauze (SG) and advanced hemostatic dressings in use by military personnel in a no-hold model. METHODS: A randomized, controlled trial was conducted using 36 swine. Animals underwent femoral arteriotomy, followed by 60 seconds of uncontrolled hemorrhage. After hemorrhage, packing with ...
Lo Joe F JF Department of Mechanical Engineering, College of Engineering and Computer Sciences, University of Michigan at Dearborn, Dearborn, MI, USA. - - 2013
Restoring tissue oxygenation has the potential to improve poorly healing wounds with impaired microvasculature. Compared with more established wound therapy using hyperbaric oxygen chambers, topical oxygen therapy has lower cost and better patient comfort, although topical devices have provided inconsistent results. To provide controlled topical oxygen while minimizing moisture loss, ...
Babaei Fatemeh - - 2013
Zebrafish is an important model organism in biological research. One of the least explored tissues of zebrafish is blood, because the existing methods for isolating blood from this organism are tedious and irreproducible. The small volume of blood collected by these methods also prohibits many biochemical and cytological analyses. This ...
Hansen Bernie - - 2013
OBJECTIVE: To compare the distribution of flow from two commercial and one handmade multihole wound infusion catheters. STUDY DESIGN: Open label experimental measurement of flow distribution in a bench top apparatus of handmade (n = 10) and two commercial (n = 10 each) wound infusion catheters with 5-6″ (12-15.2 cm) long diffusion surfaces. METHODS: The ...
Clumpner Brandon R - - 2013
Background: Common first aid tourniquets, like the Combat Application Tourniquet (CAT) of a windlass and band design, can have the band routed through the buckle in three different ways, and recent evidence indicates users may be confused with complex doctrine. Objective: The purpose of the present study is to measure ...
Polston Ryan W - - 2013
Background: Tourniquets on casualties in war have been loose in 4%?9% of uses, and such slack risks death from uncontrolled bleeding. A tourniquet evidence gap persists if there is a mechanical slack?performance association. Objective: The purpose of the present study was to determine the results of tourniquet use with slack ...
Kamran Paniz - - 2013
Parabiosis is a surgical union of two organisms allowing sharing of the blood circulation. Attaching the skin of two animals promotes formation of microvasculature at the site of inflammation. Parabiotic partners share their circulating antigens and thus are free of adverse immune reaction. First described by Paul Bert in 1864(1), ...
Kabashima Hiroaki H Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu - - 2013
Several growth factors have been used in tissue regeneration therapy. Here we describe the use of an autologous blood clot combined with gelatin for teeth affected by severe periodontitis and vertical root fracture treated using three oral surgical procedures: periodontal flap surgery, intentional tooth replantation (IR), and tooth autotransplantation. Treatment ...
Nwachukwu Benedict U BU Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2013
Traditional techniques for acetabular osteoplasty in femoral acetabular impingement have required surgical detachment of the labrum at the chondrolabral junction. Such approaches compromise labral blood flow and contribute to a limited ability for healing at the chondrolabral junction. In this technical note and accompanying video, we present a technique for ...
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