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Zhurova Mariia M Department of Laboratory Medicine and Pathology, 8249-114 Street, Edmonton, AB T6G 2R8, Canada; Research and Development, Canadian Blood Services, 8249-114 Street, Edmonton, AB T6G 2R8, - - 2014
The transfusion of red blood cells from umbilical cord blood (cord RBCs) is gathering significant interest for the treatment of fetal and neonatal anemia, due to its high content of fetal hemoglobin as well as numerous other potential benefits to fetuses and neonates. However, in order to establish a stable ...
Zhao Yanan Y Public Health Research Institute Center, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ - - 2014
Using E. rostratum-specific and pan-fungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive for fungal DNA by pan-fungal PCR with multiple fungal species identified.
Zhou Jianwei - - 2014
To date, the complete mechanism of rheumatoid arthritis (RA) remain unclear, T cells have been proposed to play an important role in the disease initiation and progression. Presently, some researchers have reported that there were skewed TCR Vβ in different samples of experimental animals or RA patients, such as in ...
Mehri Rym - - 2014
Background: The aim of the work presented in this paper is to design a microfluidic apparatus capable of providing controlled flow conditions suitable for Red Blood Cell (RBC) aggregation analysis. The linear velocity engendered from the controlled flow provides constant shear rates used to qualitatively analyze RBC aggregates. These controlled ...
Blum Martin M Institute of Zoology, University of Hohenheim, 70593 Stuttgart, - - 2014
Morphological asymmetry is a common feature of animal body plans, from shell coiling in snails to organ placement in humans. The signaling protein Nodal is key for determining this laterality. Many vertebrates, including humans, use cilia for breaking symmetry during embryonic development: rotating cilia produce a leftward flow of extracellular ...
Govey Peter M PM Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, - - 2014
Osteocytes, positioned within bone׳s porous structure, are subject to interstitial fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone adaptation to mechanical load. The objective of this study was ...
Guo Wei W Mechanical Engineering Department, Florida State University, Tallahassee, FL - - 2014
Cryogenic flow visualization techniques have been proved in recent years to be a very powerful experimental method to study superfluid turbulence. Micron-sized solid particles and metastable helium molecules are specifically being used to investigate in detail the dynamics of quantum flows. These studies belong to a well-established, interdisciplinary line of ...
Fardin M A MA Université de Lyon, Laboratoire de Physique, École Normale Supérieure de Lyon, CNRS UMR 5672, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. - - 2014
The flow between concentric cylinders is routinely used in soft matter studies. In many cases, the purpose of the setup is rheometric: the idea is to relate macroscopic changes in material properties to microscopic changes in the structure of the material. The correspondence between the modifications of the microscopic structure ...
Pooyath Lekshmy Venugopalan - - 2014
Controlled motion of artificial nanomotors in biological environments, such as blood, can lead to fascinating biomedical applications, ranging from targeted drug delivery to microsurgery, and many more. In spite of the various strategies used in fabricating and actuating nanomotors, practical issues related to fuel requirement, corrosion, and liquid viscosity have ...
Chilukuri Sandeep S Howard P Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, - - 2014
Swimming microorganisms have been previously observed to accumulate along walls in confined systems both experimentally and in computer simulations. Here, we use computer simulations of dilute populations for a simplified model of an organism to calculate the dynamics of swimmers between two walls with an external fluid flow. Simulations with ...
Deplano Valérie V Aix-Marseille Université, CNRS, Centrale Marseille, IRPHE UMR 7342, F-13384 Marseille, France. Electronic address: - - 2014
The aim of this work is to develop a unique in vitro set-up in order to analyse the influence of the shear thinning fluid-properties on the flow dynamics within the bulge of an abdominal aortic aneurysm (AAA). From an experimental point of view, the goals are to elaborate an analogue ...
Schneditz Daniel D 1Institute of Physiology, Medical University of Graz, Graz, Austria 2Division of Nephrology, Department of Internal Medicine, Medical University of Graz, Graz, - - 2014
Hemodialysis is accompanied by osmotic perturbations with distinct effects on red blood cell, plasma, and blood volumes. A series of in-vitro studies was done to analyze the separate effect on cell volume.Whole porcine blood was circulated through an extracorporeal circulation maintaining a constant blood volume. Hemoconcentration was continuously measured by ...
Stieger Tillmann T Stranski-Laboratorium für Physikalische und Theoretische Chemie, Technische Universität Berlin, Straße des 17. Juni 115, 10623 Berlin, - - 2014
We perform molecular dynamics simulations of a nematic liquid crystal flowing around a colloidal particle. We study the flow-induced modifications of the topological defects in the liquid crystal due to the presence of the colloid. We show that flow distorts Boojum defects into an asymmetrically larger downstream lobe, and that ...
Moon Ji Young JY School of Mechanical Engineering, Yonsei University, Seoul, - - 2014
Despite recent development of computational fluid dynamics (CFD) research, analysis of computational fluid dynamics of cerebral vessels has several limitations. Although blood is a non-Newtonian fluid, velocity and pressure fields were computed under the assumptions of incompressible, laminar, steady-state flows and Newtonian fluid dynamics. The pulsatile nature of blood flow ...
Gjerde Hallvard H 1Division of Forensic Medicine and Drug Abuse Research, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, - - 2014
Oral fluid is an easily available specimen for studying drug use in a cohort or population. The prevalence of drugs in samples of oral fluid is the same as the prevalence in blood if using equivalent cutoff concentrations. The cutoffs in oral fluid may be higher or lower than that ...
Medby Christian C 1Norwegian Armed Forces Medical Services 2Dept. of Anaesthesia and Intensive Care, St. Olav University - - 2014
Crystalloids and colloids are used in prehospital fluid resuscitation to replace blood loss and preserve tissue perfusion until definite surgical control of bleeding can be achieved. However, large volumes of fluids will increase bleeding by elevating blood pressure, dislodging blood clots and by diluting coagulation factors and platelets. Hypotensive fluid ...
Walski Tomasz T Institute of Biomedical Engineering and Instrumentation, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland ; Regional Specialist Hospital in Wrocław, Research and Development Centre, Kamieńskiego 73a, 51-124 Wrocław, - - 2014
The aim of our experiments was to characterise and to validate the osmotic fragility test when applied to human blood samples with no significant alterations of osmotic fragility but with a differentiating shape of the haemolysis curve. All experiments were carried out on human erythrocytes taken from the Regional Centre ...
Khaled A-R A AR Mechanical Engineering Department, King Abdulaziz University, P.O. Box 80204, Jeddah 21589, Saudi - - 2014
Enhancement of heat transfers in counterflow plate heat exchanger due to presence of an intermediate auxiliary fluid flow is investigated. The intermediate auxiliary channel is supported by transverse conducting pins. The momentum and energy equations for the primary fluids are solved numerically and validated against a derived approximate analytical solution. ...
Ferrás L L LL Institute for Polymers and Composites/I3N, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal. Electronic address: - - 2014
In this work we present semi-analytical solutions for the electro-osmotic annular flow of viscoelastic fluids modeled by the Linear and Exponential PTT models. The viscoelastic fluid flows in the axial direction between two concentric cylinders under the combined influences of electrokinetic and pressure forcings. The analysis invokes the Debye-Hückel approximation ...
Birngruber Thomas - - 2013
The blood-brain barrier (BBB) limits substance transport to the brain and is therefore the major hurdle to overcome when developing neuroactive drugs. Herein, we report on cerebral open flow microperfusion (cOFM) as a new membrane-free technique for measuring substance transport across the intact BBB. The cOFM technique is based on ...
Kuranuki Sachi - - 2013
Objective: To develop a minimally invasive interstitial fluid extraction technology (MIET) to monitor postprandial glucose area under the curve (AUC) without blood sampling, we evaluated the accuracy of glucose AUC measured by MIET and compared with that by blood sampling after food intake. Methods: Interstitial fluid glucose AUC (IG-AUC) following ...
Talon Laurent - - 2013
Simulating flow of a Bingham fluid in porous media still remains a challenging task as the yield stress may significantly alter the numerical stability and precision. We present a Lattice-Boltzmann TRT scheme that allows the resolution of this type of flow in stochastically reconstructed porous media. LB methods have an ...
Plotkin David D Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University, Mississippi State, MS - - 2013
Although adult Lepidoptera are not often considered medically relevant, some butterflies and moths are notorious for their consumption of mammalian body fluids. These Lepidoptera can be blood-feeding (hematophagous), tear-feeding (lachryphagous), or sweat-feeding (we use the term "sudophagous"). Blood-feeding Lepidoptera have been observed piercing the skin of their hosts during feeding, ...
Kandel H N HN Department of Mathematics, Ryerson University, Toronto, Ontario M5B 2K3, - - 2013
We investigate the interfacial instability of the steady uniform flow of a fluid-film layer down a permeable incline. A theoretical model is obtained by coupling the clear fluid flow equations governing the fluid film with Darcy's law for the filtration of fluid through the porous medium. A linear stability analysis ...
Lester D R - - 2013
We show that chaotic advection is inherent to flow through all types of porous media, from granular and packed media to fractured and open networks. The basic topological complexity inherent to all porous media gives rise to chaotic flow dynamics under steady flow conditions, where fluid deformation local to stagnation ...
Morin Kristen T - - 2013
The development of engineered microvessels with clinically-relevant characteristics is a critical step toward the creation of engineered myocardium. Alignment is one such characteristic that must be achieved, as it both mimics native capillary beds and provides natural inlet and outlet sides for perfusion. A second characteristic that is currently deficient ...
Mayur Manik - - 2013
Electro-osmotic flows have seen remarkable applications in lab-on-a-chip based microdevices owing to their lack of moving components, durability and non-dispersive nature of the flow profiles under specifically designed conditions. However, such flows may typically suffer from classical Faradaic artifacts like electrolysis of the solvent which affects the flow rate control. ...
Ghatage Dhairyasheel - - 2013
We introduce a method to obtain steady-state uniaxial exponential-stretching flow of a fluid (akin to extensional flow) in the incompressible limit, which enables us to study the response of suspended macromolecules to the flow by computer simulations. The flow field in this flow is defined by v_{x}=εx, where v_{x} is ...
Bussemaker Madeleine J - - 2013
Sonochemical activity is dependent on flow patterns within the reactor and either no affect or a decrease in activity was observed at 376, 995, and 1179kHz from overhead stirring. The interaction of fluid flow with ultrasound was further investigated in this study with circulatory flow. The effect of fluid circulation ...
Levine D M - - 2013
Multi-lumen extensions used to infuse multiple fluids via a single intravenous cannula might increase resistance and so limit the flow that can be achieved. We constructed low-pressure and high-pressure models and compared the effect of two different multi-lumen extensions on flow rate. Both multi-lumen extensions reduced flows by up to ...
Gjerde Hallvard - - 2013
Analysis of samples of oral fluid (mixed saliva) is increasingly being used to detect recent drug use. The aim of this investigation was to assess the suitability of testing oral fluid as a biomarker for the presence of 4 benzodiazepines in blood and its possible application in clinical settings and ...
Zhu P - - 2013
Sialolithiasis is a common disease caused by intraductal stones, formed by reduction in salivary flow, salivary stagnation, and metabolic events. We used computational fluid dynamics to investigate changes in salivary flow field around parotid stones of different shapes. Three-dimensional configurations of the Stensen's duct were reconstructed from computed tomography sialographic ...
Lucas K - - 2013
Unlike most medusae that forage with tentacles trailing behind their bells, several species forage upstream of their bells using aborally located tentacles. It has been hypothesized that these medusae forage as stealth predators by placing their tentacles in more quiescent regions of flow around their bells. Consequently, they are able ...
Nelson Joey M - - 2013
The flow structure around the lateral antennular flagellum of the freshwater crayfish, Procambarus clarkii, was quantified to determine how antennule morphology and flicking kinematics affect fine-scale flow surrounding their chemosensory sensilla, called aesthetascs. Particle image velocimetry was used to measure velocity and vorticity of flow between aesthetascs of dynamically scaled ...
Peralta Marina - - 2013
Hydrodynamic forces play a central role in organ morphogenesis. The role of blood flow in shaping the developing heart is well established, but the role of fluid forces generated in the pericardial cavity surrounding the heart is unknown. Mesothelial cells lining the pericardium generate the proepicardium (PE), the precursor cell population of the ...
Ortega J M - - 2013
A porous media model is developed for non-Newtonian blood flow through reticulated foam at Reynolds numbers ranging from 10(-8) to 10. This empirical model effectively divides the pressure gradient versus flow speed curve into three regimes, in which either the non-Newtonian viscous forces, the Newtonian viscous forces, or the inertial ...
Maciejczyk E - - 2013
Hypothesis have been made that relatively high level of mannitol present in the tissues of fly agaric (Amanita muscaria) enables more efficient transportation of these active substances into the brain and thus enhance their total activity. It may have been supported by the fact that hallucinogenic effect after A. muscaria ...
Datta Sujit S - - 2013
We use confocal microscopy to directly visualize the spatial fluctuations in fluid flow through a three-dimensional porous medium. We find that the velocity magnitudes and the velocity components both along and transverse to the imposed flow direction are exponentially distributed, even with residual trapping of a second immiscible fluid. Moreover, ...
Yao Wei - - 2013
Based on comparison between fundamental theories of Traditional Chinese Medicine (TCM) and Western Medicine (WM) and modern scientific research on meridians, we find that "Qi" in TCM is closely related to tissue fluid. In this study, the essence of Qi is explored in the view of circulation of blood and ...
Haward Simon J - - 2013
Hyaluronic acid (HA) is an important bio-macromolecule, which fulfils a number of vital physiological functions (especially in the joint synovial fluid) and also has consumer and pharmaceutical applications. HA solution properties have already been quite thoroughly characterized in response to steady shear flows but are less well understood in highly-deforming ...
Rees Julia M - - 2013
This paper presents an overview of the developments that have been made towards the design of an inline rheometer that has the capabilities for monitoring in real time the viscous constitutive parameters of non-Newtonian fluids in a pipe flow. This has potential applications for a wide range of fluids, including ...
Sefiane Khellil - - 2013
The objective of this review is to investigate different deposition patterns from dried droplets of a range of fluids: paints, polymers and biological fluids. This includes looking at mechanisms controlling the patterns and how they can be manipulated for use in certain applications such as medical diagnostics and nanotechnology. This ...
Vázquez Beatriz Y Salazar - - 2013
The microcirculation presents functional organic structures in the range of 1-100 micrometers, commensurate with the upper end of nanotechnology constructs. When devices are designed and deployed to deliver treatment via the circulation they ultimately contend with the smallest dimensions of both healthy and impaired microvessels, particularly the capillary system whose ...
Zhang Wei-Bo - - 2013
Propagated sensation along meridians (PSM) is a phenomenon that a sensation moves along meridians during stimulation of an acupoint. PSM has an appearance rate of 1.3% among people and have characteristics of low speed, going toward afflicted sites and being blocked by physical pressure which is difficult to be explained ...
Dias Eduardo O - - 2013
Variable-gap Hele-Shaw flows consider viscous fluid displacements resulting from the lifting or squeezing of the upper cell plate, while the lower plate remains at rest. Conventionally, researchers focus on the situation in which the cell plates are perfectly parallel. We study a slightly different version of the problem, where the ...
Khali S - - 2013
In this work the instability of the Taylor-Couette flow for Newtonian and non-Newtonian fluids (dilatant and pseudoplastic fluids) is investigated for cases of finite aspect ratios. The study is conducted numerically using the lattice Boltzmann method (LBM). In many industrial applications, the apparatuses and installations drift away from the idealized ...
Chengala Anwar - - 2013
Using high-speed digital holographic microscopy and microfluidics, we discover that, when encountering fluid flow shear above a threshold, unicellular green alga Dunaliella primolecta migrates unambiguously in the cross-stream direction that is normal to the plane of shear and coincides with the local fluid flow vorticity. The flow shear drives motile ...
Haaning Louise Sejling - - 2013
We present experiments and theory for flows of sugar or salt solutions in cylindrical tubes with semipermeable walls (hollow fiber membranes) immersed in water, quantifying the strength of the osmotic driving force in relation to the dimensionless parameters that specify the system. The pumping efficiency of these flows is limited ...
Vásquez Diana M - - 2013
Perfluorocarbon (PFC) emulsions used as artificial oxygen carriers lack colloid osmotic pressure (COP) and must be administered with colloid-based plasma expanders (PEs). Although PFC emulsions have been widely studied, there is limited information about PFC emulsion interaction with PEs and blood. Their interaction forms aggregates due to electrostatic and rheological ...
Franz C - - 2013
Recent studies indicate that various types of vesicles, like microparticles (MP) and exosomes, are present in blood, saliva, bone marrow, urine and synovial fluid. These vesicles, which are released upon activation or shear stress, are thought to play a role in coagulation, neovascularisation, inflammation and intercellular signalling. Seminal fluid is ...
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