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Treeby Bradley E - - 2011
The ultrasound attenuation coefficient and dispersion from 0-70 MHz in whole human blood and its components (red blood cells and plasma) at 37°C is reported. The measurements are made using a fixed path substitution technique that exploits optical mechanisms for the generation and detection of ultrasound. This allows the measurements ...
Lanaux Travis M - - 2011
Interpretation of blood smears is commonly used to provide rapid laboratory evaluation of animals in veterinary emergency practice, but the accuracy of results of blood smear interpretation by emergency room personnel (ERP) compared with evaluation by trained veterinary clinical pathology personnel is unknown. The goal of this study was to ...
Toner Richard W - - 2011
Background: Little is known about the economics of acquiring and processing the more than 14 million units of red blood cells used annually in the US. Objective: To determine the average price paid by hospitals to suppliers for a unit of red blood cells and to identify cost variations by ...
Hosoda Masahiro - - 2011
A continuous measurement system, with a ventilation-type accumulation chamber, was developed for radon exhalation rate determination. A reasonable sampling flow rate for the measurement system was determined by comparing the values obtained by the system with those obtained by a grab sampling method. The sampling flow rate of passage through ...
Inui Koji - - 2011
Air-segmentation is applied to amplitude-modulated multiplexed flow analysis, which we proposed recently. Sample solutions, the flow rates of which are varied periodically, are merged with reagent and/or diluent solution. The merged stream is segmented by air-bubbles and, downstream, its absorbance is measured after deaeration. The analytes in the samples are ...
Fuchiwaki Yusuke - - 2011
Flow-through polymerase chain reaction (PCR) microfluidic systems for fast, small-volume DNA amplification on a single chip are significantly impacting medical and bioanalytical research. We have fabricated an improved, practical flow-through PCR chip by weighting a pressure-sensitive polyolefin (PSP) film onto a cyclo-olefin polymer (COP) substrate. The substrate was cut so ...
Dunn J F - - 2011
Laser speckle perfusion imaging (LSPI) is a minimally invasive optical measure of relative changes in blood flow, providing real-time, high resolution, two-dimensional maps of vascular structure. Standard LSI imaging uses a light-reflective geometry that limits the measurement to a thin surface layer of 0.2-1 mm. The objective of this study was ...
Iuliano Blase - - 2011
Abstract Background: T'ai chi chuan, the ancient Chinese martial art, is practiced by millions of people worldwide and is an activity of moderate intensity that involves slow, circular movements. Evidence of substantial health benefits of t'ai chi chuan is emerging, however, the physiologic mechanisms are not well-understood. T'ai chi chuan ...
Wang Lili - - 2011
Multicolor flow cytometer assays are routinely used in clinical laboratories for immunophenotyping, -monitoring disease and treatment, and determining prognostic factors. However, existing methods for quantitative measurements have not yet produced satisfactory results. This chapter details a procedure for quantifying surface and intracellular protein biomarkers by calibrating the output of a ...
Sharma Gaurav - - 2011
The Transfusion Medicine Service (TMS) covers diverse clinical and laboratory-based services that must be delivered with accuracy, efficiency and reliability. TMS oversight is shared by multiple regulatory agencies that cover product manufacturing and validation standards geared toward patient safety. These demands present significant informatics challenges. Over the past few decades, ...
Beiderman Yevgeny - - 2011
An optical approach allowing the extraction and the separation of remote vibration sources has recently been proposed. The approach has also been applied for medical related applications as blood pressure and heart beats monitoring. In this paper we demonstrate its capability to monitor glucose concentration in blood stream. The technique ...
Liu Tan - - 2011
We proposed to measure the metabolic rate of oxygen (MRO(2)) in small animals in vivo using a multimodal imaging system that combines laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) and spectral-domain optical coherence tomography (SD-OCT). We first tested the capability of the multimodal system to measure flow rate in a phantom made ...
Kuranov Roman V - - 2011
Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is ...
Hopkins Heidi - - 2011
Malaria rapid diagnostic tests (RDTs) are increasingly used by remote health personnel with minimal training in laboratory techniques. RDTs must, therefore, be as simple, safe and reliable as possible. Transfer of blood from the patient to the RDT is critical to safety and accuracy, and poses a significant challenge to ...
Rolf Marijn P - - 2011
Eddy current induced velocity offsets are of concern for accuracy in cardiovascular magnetic resonance (CMR) volume flow quantification. However, currently known theoretical aspects of eddy current behavior have not led to effective guidelines for the optimization of flow quantification sequences. This study is aimed at identifying correlations between protocol parameters ...
Rodríguez-Villarreal Angeles Ivón - - 2010
The continuous flow focussing and manipulation of particles and cells are important factors in microfluidic applications for performing accurate and reproducible procedures downstream. Many particle focussing methods require complex setups or channel designs that can limit the process and its applications. Here, we present diamagnetic repulsion as a simple means ...
Shats M - - 2010
The dimensionality of turbulence in fluid layers determines their properties. We study electromagnetically driven flows in finite-depth fluid layers and show that eddy viscosity, which appears as a result of three-dimensional motions, leads to increased bottom damping. The anomaly coefficient, which characterizes the deviation of damping from the one derived ...
Moncalvo D - - 2010
Critical air/water blow-downs in safety valves for qualities from 0.01 to 0.113 and mass flow rates from 1.5 up to 4.3kg/s have been observed in our test facility. These critical blow-downs are characterized by a large void fraction and by an intense mixing of the phases both in the valve ...
Lighton J R B - - 2011
Flow-through respirometry is a powerful, accurate methodology for metabolic measurement that is applicable to organisms spanning a body mass range of many orders of magnitude. Concentrating on flow-through respirometry that utilizes a chamber to contain the experimental animals, we describe the most common flow measurement and control methodologies (push, pull ...
Filipovic Nenad - - 2011
Geometrical changes of blood vessels, called aneurysm, occur often in humans with possible catastrophic outcome. Then, the blood flow is enormously affected, as well as the blood hemodynamic interaction forces acting on the arterial wall. These forces are the cause of the wall rupture. A mechanical quantity characteristic for the ...
Chiriacò Maria Serena - - 2011
A flow-injection impedimetric immunosensor for the sensitive, direct and label-free detection of cholera toxin is reported. A limit of detection smaller than 10 pM was achieved, a value thousands of times lower than the lethal dose. The developed chips fulfil the requirement of low cost and quick reply of the ...
Xu Tiantian - - 2010
Conventional (Doppler-based) blood flow velocity measurement methods using ultrasound are capable of resolving the axial component (i.e., that aligned with the ultrasound propagation direction) of the blood flow velocity vector. However, these methods are incapable of detecting blood flow in the direction normal to the ultrasound beam. In addition, these ...
Rhamy Jennifer F - - 2010
Blood centers have expertise in following federally mandated standards and establishing rigorous quality systems. Medicare participating hospitals and their laboratories must be compliant with the requirements of the Centers for Medicare and Medicaid Services. Following standards and experiencing unannounced surveys allow blood centers and hospitals to organize and strengthen their ...
Pollitt Rodney J - - 2010
The potential of newborn blood-spot screening is expanding rapidly with the development of new analytical techniques and treatment methods. At the same time, some existing programmes, particularly that for congenital hypothyroidism, are coming under scrutiny because of suspicion that they are being shaped by analytical performance rather than evidence of ...
Liu Biyue B Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, - - 2010
A three dimensional mathematical model with a linear plaque growth function was developed to investigate the geometrical adaptation of atherosclerotic plaques in coronary arteries and study the influences of flow wall shear stress (WSS), blood viscosity and the inlet flow rate on the growth of atherosclerotic plaques using computational plaque ...
Tyrrell A - - 2011
Aim/Objective: To compare the cost and effectiveness of Copper Sulphate (CS) and HemoCue (HC) methods for screening blood donors for anaemia. Background: Robust information from developing countries about cost and effectiveness of anaemia screening methods for blood donors is scarce. In such countries there are widespread shortages of blood, so ...
Bong Ki Wan - - 2011
We present the construction and operation of a compressed-air driven flow system that can be used for a variety of microfluidic applications that require rapid dynamic response and precise control of multiple inlet streams. With the use of inexpensive and readily available parts, we describe how to assemble this versatile ...
Qazi S Junaid S - - 2010
High-energy angle-dispersive X-ray diffraction has been used to study the alignment of colloidal suspension of kaolinite particles in water as they flow along a pipe. X-rays with energies above 25 keV have a major advantage, as they can penetrate through thick samples and walls of containers and permit investigation of ...
Suh Ga-Young GY Department of Mechanical Engineering, Stanford University, 318 Stanford Drive, Stanford, CA 94305, - - 2011
Hemodynamic conditions are hypothesized to affect the initiation, growth, and rupture of abdominal aortic aneurysms (AAAs), a vascular disease characterized by progressive wall degradation and enlargement of the abdominal aorta. This study aims to use magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) to quantify flow stagnation and recirculation ...
Escobedo Carlos - - 2010
We quantify the efficacy of flow-through nanohole sensing, as compared to the established flow-over format, through scaling analysis and numerical simulation. Nanohole arrays represent a growing niche within surface plasmon resonance-based sensing methods, and employing the nanoholes as nanochannels can enhance transport and analytical response. The additional benefit offered by ...
Luštrik Matevž - - 2010
This study evaluated the performance of two bottom-spray coaters and the effect of pellet-size variability on coating uniformity. A conventional Wurster chamber was used for the first group of trials, and a Wurster chamber with a novel swirl-flow generator design was used for the second. The results confirmed that when ...
Wei Huibin - - 2011
Porous membranes have been fabricated based on the development of the perforated membrane mold [Y. Luo and R. N. Zare, Lab Chip, 2008, 8, 1688-1694] to create a single filter that contains multiple pore sizes ranging from 6.4 to 16.6 µm inside a monolithic three-dimensional poly(dimethylsiloxane) microfluidic structure. By overlapping ...
Sorimachi T - - 2011
If blood flow in the ICA is reduced by the use of a distal filter during CAS, flow stagnation proximal to the filter occurs and this increases the probability of floating debris. The floating debris that remains after filter retrieval may cause cerebral embolism. However, if blood flow is increased ...
Carbone G - - 2010
Heart and cerebrovascular diseases such as arteriosclerosis and myocardial ischemia dysfunction are currently among the main causes of death in developed countries. Recently, wave intensity (WI), which is an index used to obtain the force of cardiac contraction, has been investigated as a method for early-stage diagnosis of the above-mentioned ...
Denniff Philip - - 2010
Before shipping and storage, dried blood spot (DBS) samples must be dried in order to protect the integrity of the spots. In this article, we examine the time required to dry blood spot samples and the effects of different environmental conditions on their integrity. Under ambient laboratory conditions, DBS samples ...
Hund Samuel J - - 2010
Computational prediction of blood damage has become a crucial tool for evaluating blood-wetted medical devices and pathological hemodynamics. A difficulty arises in predicting blood damage under turbulent flow conditions because the total stress is indeterminate. Common practice uses the Reynolds stress as an estimation of the total stress causing damage ...
Manz P - - 2010
By means of a unique probe array, the interaction between zonal flows and broad-band drift-wave turbulence has been investigated experimentally in a magnetized toroidal plasma. Homogeneous potential fluctuations on a magnetic flux surface, previously reported as long range correlations, could be traced back to a predator-prey-like interaction between the turbulence ...
Sorimachi Takatoshi - - 2010
Distal filter protection allows for continuous cerebral perfusion during carotid artery stenting (CAS), although a higher risk of debris migrating into the cerebral arteries compared with other protection systems has been reported. To improve the extent of debris capture, we used routine aspiration of blood located proximal to the filter ...
Sheinfeld Adi - - 2010
We demonstrate the use of tone-burst excitation and time-gated spectral analysis for photoacoustic Doppler mapping of flow in an unperturbed vessel phantom and in a vessel with a spatially varying lumen. The method, which mimics pulsed Doppler ultrasound, enables simultaneous measurement of axial position and flow as well as complete ...
English Emmet J - - 2010
A method is presented for measuring the aeroacoustic source strength in ducts with flow at frequencies at which the wave motion can be considered substantially one-dimensional. The method is based on coherent power flux measurements using pairs of microphones positioned both upstream and downstream of the source region. The method ...
Duffey Trisha A TA Department of Chemistry, University of Washington, Seattle, Washington 98195, United - - 2010
We report a new assay of N-acetylgalactosamine-4-sulfatase (aryl sulfatase B) activity in dried blood spots (DBS) for the early detection of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) in newborn screening. The assay uses a synthetic substrate consisting of N-acetylgalactosamine-4-sulfate moiety glycosidically linked to a hydrophobic residue and furnished with a tert-butyloxycarbamido group ...
Drescher Knut - - 2010
Swimming microorganisms create flows that influence their mutual interactions and modify the rheology of their suspensions. While extensively studied theoretically, these flows have not been measured in detail around any freely-swimming microorganism. We report such measurements for the microphytes Volvox carteri and Chlamydomonas reinhardtii. The minute (∼0.3%) density excess of ...
Wang Jun J NanoSystems Biology Cancer Center, California Institute of Technology, Pasadena, CA 91125, - - 2010
We describe an automated, self-powered chip based on lateral flow immunoassay for rapid, quantitative, and multiplex protein detection from pinpricks of whole blood. The device incorporates on-chip purification of blood plasma by employing inertial forces to focus blood cells away from the assay surface, where plasma proteins are captured and ...
Sorimachi Takatoshi - - 2010
To determine any relationship between angiographically documented flow impairment associated with the Angioguard XP cerebral protection filter during carotid artery stenting (CAS) and the condition of the pores in the retrieved filter. To obtain baseline characteristics of the Angioguard XP, an unused filter was fully expanded and examined photographically from ...
Messinger R J - - 2010
We show that nanoscale surface roughness, which commonly occurs on microfabricated metal electrodes, can significantly suppress electro-osmotic flows when excess surface conductivity is appreciable. We demonstrate the physical mechanism for electro-osmotic flow suppression due to surface curvature, compute the effects of varying surface conductivity and roughness amplitudes on the slip ...
Sander Johannes - - 2011
Quantification of nitisinone, 2-(nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione (NTBC) has been repeatedly described. Nevertheless monitoring of NTBC has not yet become part of routine therapy surveillance in tyrosinaemia type I (OMIM 276700). We developed a blood spot test to facilitate collection and transport of samples. Furthermore, the test material can be used for determination ...
Yamada Chisa - - 2010
Hyperkalemia is a serious complication of rapid and massive blood transfusion due to high plasma potassium (K) in stored red blood cell (RBC) units. A potassium adsorption filter (PAF) was developed in Japan to remove K by exchanging with sodium (Na). We performed an in vitro evaluation of its efficacy ...
Zhu Taishan - - 2010
The presented work probes the fundamentals of Knudsen forces. Using the direct simulation Monte Carlo (DSMC) method, the flows induced by temperature inhomogeneity within a representative configuration and the Knudsen force acting on a heated microbeam are captured as functions of Knudsen number in the entire flow regime. Both flow ...
Karinen Ritva - - 2010
The aim of this study was to evaluate the stability of blood concentrations of a variety of illegal and medicinal drugs that are important for forensic analyses when spiked and stored in Vacutainer or Venosafe evacuated plastic collection tubes compared to Vacutainer evacuated glass tubes. Tubes were filled with spiked ...
Sharma Mradul - - 2010
The transport of angular momentum in the outward direction is the fundamental requirement for accretion to proceed in an accretion disk. This objective can be achieved if the accretion flow is turbulent. Instabilities are one of the sources for the turbulence. We study a differentially rotating compressive flow in the ...
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