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Crimmins Eileen E a Davis School of Gerontology , University of Southern California , Los Angeles , California , - - 2014
Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used ...
Prakash Kottapalli Ajay Giri AG School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. Center for Environmental Sensing and Modeling (CENSAM) IRG, Singapore-MIT Alliance for Research and Technology (SMART), 138602, - - 2014
Evolution bestowed the blind cavefish with a resourcefully designed lateral-line of sensors that play an essential role in many important tasks including object detection and avoidance, energy-efficient maneuvering, rheotaxis etc. Biologists identified the two types of vital sensors on the fish bodies called the superficial neuromasts and the canal neuromasts ...
Fitts Michelle K MK Department of Bioengineering, University of Utah, Salt Lake City, Utah, - - 2014
Surgically-created blood conduits used for chronic hemodialysis, including native arteriovenous fistulas (AVFs) and synthetic AV grafts (AVGs), are the lifeline for kidney failure patients. Unfortunately, each has its own limitations: AVFs often fail to mature to become useful for dialysis and AVGs often fail due to stenosis as a result ...
Singh Vimal K VK Stem Cell Research Laboratory, Department of Biotechnology, Delhi Technological University Delhi, - - 2014
Blood transfusions are routinely done in every medical regimen and a worldwide established collection, processing/storage centers provide their services for the same. There have been extreme global demands for both raising the current collections and supply of safe/adequate blood due to increasingly demanding population. With, various risks remain associated with ...
Schudt Florian F Technische Hochschule Mittelhessen - University of Applied Sciences, Giessen, - - 2014
The respiratory flow is a good indicator of sleep-related breathing disorders. Common praxis is to use a pneumotachograph as the golden standard for flow measurement. However, it does not have to be necessarily the best possible test device for long-term condition, because the device is very uncomfortable and rarely suitable ...
Tarbell John M JM Department of Biomedical Engineering, The City College of New York, New York, NY - - 2014
This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the 1960s when associations between flow characteristics, particularly blood flow-induced wall shear stress, and ...
Tuziuti Toru T National Institute of Advanced Industrial Science and Technology (AIST), Nagoya 463-8560, Japan. Electronic address: - - 2013
We measured longitudinal speed of sound for matrix[poly(lactic acid)]-additive(clay particles) composite rectangular-solid specimen prepared by injection molding. It was found that the speed of sound measured in the direction along the longer side of the specimen was the highest at the middle of the specimen. This trend corresponded with that ...
Nozaki K - - 2013
The sibilant /s/ is produced by raising the tongue against the roof of the mouth to form a narrow constriction, which is adjusted so that the airstream emerging from it impinges on the incisors. However, the location where the sibilant sound occurs is unclear, as are the details of the ...
Reif Roberto R University of Washington, Department of Bioengineering, Seattle, WA 98195, - - 2013
In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud ...
Kniesburges Stefan - - 2013
Within the fully coupled multiphysics phonation process, the fluid flow plays an important role for sound production. This study addresses phenomena in the flow downstream of synthetic self-oscillating vocal folds. An experimental setup consisting of devices for producing and conditioning the flow including the main test channel was applied. The ...
de Vries Ronald - - 2013
Background: The European Bioanalysis Forum dried blood spots (DBS)/microsampling consortium is reporting back from the experiments they performed on further documenting the potential hurdles of the DBS technology. This paper is focused on the impact of hematocrit changes on DBS analyses. Results: The hematocrit can have an effect on the ...
Timmerman Philip - - 2013
The European Bioanalysis Forum dried blood spots/microsampling consortium is reporting back from the experiments they performed on further documenting the potential hurdles of the DBS technology. Their experiments focused on the impact of hematocrit changes, IS addition, spot homogeneity, aging of spots and stability of fresh blood and cards. Results ...
Seo Jung Hee JH Johns Hopkins University, Baltimore, MD 21218, - - 2013
A multiphysics simulation approach is developed for predicting cardiac flows as well as for conducting virtual echocardiography (ECHO) and phonocardiography (PC) of those flows. Intraventricular blood flow in pathological heart conditions is simulated by solving the three-dimensional incompressible Navier-Stokes equations with an immersed boundary method, and using this computational hemodynamic ...
Khosla Sid M - - 2013
Until now, skewing of the volumetric flow rate (Q) curve was thought to be due to the inertance effects produced by the vocal tract. The goal of these experiments is to measure the volumetric flow rate at the entrance and exit of the glottis during the closing phase in a ...
Boij Susann - - 2013
In vehicle applications, absorbing materials are often used to attenuate sound. In, for example, exhaust systems and on noise encapsulations, the absorber is exposed to flow. This creates a boundary layer above the absorber, which affects the impedance of the surface, and hence alters the absorption properties. In addition to ...
Tze Wei Chu Derek - - 2013
The technique presented here uses an impedance head to measure the input impedance spectrum of a physical model of a vocal tract, and then to inject a known glottal flow waveform into the tract. The sound measured outside the mouth is used to evaluate inverse filtering techniques by comparison with ...
Fujiso Yo - - 2013
Human unvoiced fricative speech sounds such as [s] and [f] are produced by a complex fluid-structure interaction. Indeed, a moderate Reynolds number (100 ≤ Re ≤ 10000) turbulent jet is issued from a constriction somewhere in the vocal tract formed between the hard palate and an articulator such as tongue, teeth, or lips. By ...
Ko Myungkwon - - 2013
Flow noise is a kind of hydrodynamic noise, which is created by turbulent flow in the boundary layer around the hydrophone. Although the turbulent pressure is not a true acoustic noise in that its influence decreases rapidly with distance, it acts as a self-noise source. In general, since the spectrum ...
Kaburagi Tokihiko - - 2013
This paper presents recent progress in research examining the mechanisms of voice generation and a method for physiologically based speech synthesis. The overarching goal of this research is the precise modeling of interactions among physical systems involved in the processes underlying voice generation. In the basic voice generation system, a ...
Zhou Xinhui - - 2013
Production of fricatives involves a narrow supraglottal constriction along the vocal tract. Air flows through the constriction, and generates turbulent noise source(s) by impinging on some obstacles downstream. In post-glossectomy speakers, the production of /s/ and /sh/ is often problematic. It is mainly caused by the tongue surgery, which changes ...
Kniesburges Stefan - - 2013
Within the fully coupled multi-physics process of phonation the fluid flow plays an important role in the sound production. Therefore, the study addresses phenomena in the flow downstream of synthetic self-oscillating vocal folds and their influence on the sound production. A test setup consisting of devices for producing and conditioning ...
Smith Simeon L - - 2013
The effect of subglottic stenosis on vocal fold vibration is investigated. An idealized stenosis is defined, parameterized, and incorporated into a two-dimensional, fully-coupled finite element model of the vocal folds and laryngeal airway. Flow-induced responses of the vocal fold model to varying severities of stenosis are compared. The model vibration ...
López-Caballero Miguel M Departamento de Física y Matemática Aplicada, University of Navarra, P.O. Box 177, E-31080 Pamplona, - - 2013
The existence of energy cascades as signatures of conserved magnitudes is one of the universal characteristics of turbulent flows. In homogeneous 3D turbulence, the energy conservation produces a direct cascade from large to small scales, although in 2D, it produces an inverse cascade pointing towards small wave numbers. In this ...
Chandra Mani M Department of Physics, Indian Institute of Technology, Kanpur 208016, - - 2013
We employ detailed numerical simulations to probe the mechanism of flow reversals in two-dimensional turbulent convection. We show that the reversals occur via a vortex reconnection of two attracting corner rolls having the same sign of vorticity, thus leading to major restructuring of the flow. Large fluctuations in heat transport ...
Klopsch Christian C Department of Neurobiology, University of Vienna, Vienna, Austria. - - 2013
When hungry, the wandering spider Cupiennius salei is frequently seen to catch flying insect prey. The success of its remarkable prey-capture jump from its sitting plant into the air obviously depends on proper timing and sensory guidance. In this study, it is shown that particular features of the airflow generated ...
Yu Lu - - 2013
BACKGROUND:: Undetected apnea can lead to severe hypoxia, bradycardia, and cardiac arrest. Tracheal sounds entropy has been proved to be a robust method for estimating respiratory flow, thus maybe a more reliable way to detect obstructive and central apnea during sedation. METHODS:: A secondary analysis of a previous pharmacodynamics study ...
Hammer Michael J - - 2013
Phonatory onset is important for speech and voice and may be substantially impaired in people with Parkinson's Disease (PD). However, the physiologic contributions of laryngeal and respiratory control to phonatory onset in PD are not well understood. Acoustic measurement of phonatory onset in neurological disease has been limited due to ...
Maina John N JN Department of Zoology, University of Johannesburg, Johannesburg, South - - 2013
Complete blood-gas barrier breaks (BGBBs) and epithelial-epithelial cells connections breaks (E-ECCBs) were enumerated in the lungs of free range chickens, Gallus gallus variant domesticus after vascular perfusion at different pressures. The E-ECCBs surpassed the BGBBs by a factor of ~2. This showed that the former parts of the gas exchange ...
Dai Xiwen - - 2012
In this paper, a theoretical model is developed to study the acoustical response of a Helmholtz resonator as a duct-branched acoustic absorber subjected to both high-intensity sound and grazing flow. The present model is comprised of a discrete vortex model in combination with a one-dimensional duct sound propagation model. The ...
Zhao Jing - - 2012
BACKGROUND AND AIMS: Disturbances of microcirculation and hemorheological changes in the inner ear are the results of noise-induced hearing loss (NIHL). Both the disturbances of microcirculation and hemorheological changes are the etiologies of NIHL development, but they are also the results. Although previous reports that inhalation of high concentration of ...
Nilsson Anders - - 2012
PURPOSE: To evaluate accuracy and noise properties of a novel time-resolved, three-dimensional, three-directional phase contrast sequence with variable velocity encoding (denoted 4D-vPC) on a 3 Tesla MR system, and to investigate potential benefits and limitations of variable velocity encoding with respect to depicting blood flow patterns. MATERIALS AND METHODS: A ...
Dehner Rick - - 2012
Broadband noise, accompanying the flow separation and turbulence, is studied for an automotive centrifugal compressor on a steady-flow turbocharger bench facility. When operated in the mid-flow region, the current compressor exhibited elevated broadband noise at high frequencies, which was evident both in the upstream compressor duct and external sound pressure ...
Guzmán-Lastra Francisca - - 2012
Self-propelled microorganisms, such as unicellular algae or bacteria, swim along their director relative to the fluid velocity. Under a steady shear flow the director rotates in close orbit, a periodic structure that is preserved under an oscillatory shear flow. If the shear flow is subjected to small fluctuations produced by ...
Zhang Yingze Y Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, - - 2012
This review examines the recent literature on molecular biomarkers of idiopathic pulmonary fibrosis (IPF). Specific attention is dedicated to the recent studies that identified the genes associated with IPF and the peripheral blood biomarkers that predict outcome in IPF. Multiple studies attempted to identify diagnostic and predictive biomarkers in IPF. ...
Jing Xiaodong - - 2012
This paper addresses the problem how to measure acoustic impedance of microperforation panels (MPPs) under flow conditions. Since 1960s, many different methods have been proposed to tackle this problem, mainly motivated by the aim of reducing noise emission from aeroengines, ventilators and other fluid machines. It has been found that ...
Xu Yaoqiang - - 2012
ABSTRACT Background: Hypoperfusion of the pulmonary vascular bed under the condition of congenital cardiac malformations may lead to progressive pulmonary vascular disease. To improve the mechanistic understanding of this disease, we examined the biochemical and morphological changes of the lung in a relevant animal model and provided valuable insights into ...
Ivanenko Natalya B - - 2012
Determination of aluminum (Al), beryllium (Be), cadmium (Cd), chromium (Cr), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), and thallium (Tl) concentrations in human blood using high-frequency modulation polarization Zeeman graphite furnace atomic absorption spectrometry (GFAAS) was performed. No sample digestion was used in the current study. Blood samples were ...
Meesters Roland Jw - - 2012
Background: The hematocrit effect is a hurdle for successful introduction of the dried blood spot (DBS) in a regulated environment. Recently, attempts were taken to overcome the hematocrit effect by whole-cut DBS analysis. This paper presents the next-generation whole-cut DBS; dried matrix on paper disks (DMPD). Results: DMPD eliminated the ...
Wang Ziqiang Z Shandong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs Ministry of Health, Shandong Academy of Medical Sciences, Ji'nan, Shandong, - - 2012
Peripheral blood microRNAs (miRNAs) are endogenous, noncoding small RNAs present in blood. Because of their size, abundance, tissue specificity, and relative stability in peripheral circulation, they offer great promise of becoming a novel noninvasive biomarker. However, the mechanism by which they are secreted, their biological function, and the reason for ...
Robbins Anthony - - 2012
When the US Centers for Disease Control met a hard wall of political restraint in attempting a full response to the emergency of AIDS in the early 1980s, it was possible to move toward protection of blood and blood products from the legislative branch of government instead - despite resistance ...
Yang Ling - - 2012
Morbidity from allergic diseases is increasing. Basophils play a critical role in systemic anaphylaxis and chronic allergic inflammation. The prenatal environment must be regarded as a possible early risk factor for allergic diseases in children. Our objective was to determine if basophils harvested from neonates genetically predisposed to atopic disease ...
Uhl J-F - - 2012
The aim of this paper is to demonstrate the location of the venous foot pump using an anatomical study. Four hundred cadaveric feet were injected with green neoprene latex followed by a dissection. A coloured segmentation of the venous system was achieved. The Lejars' concept of the venous sole of ...
Nogueira R B - - 2012
Systemic vascular impedance represents the retrograde strength of the blood flow to the left ventricle, thus it is one of the main compounds of afterload. Mitral regurgitation is markedly sensitive to afterload alterations. The purpose of this study was to evaluate muscular arterial impedance in dogs with chronic degenerative mitral ...
Bonnin Philippe - - 2012
BACKGROUND AND AIMS: Active Crohn's disease affects intestine but may alter other locations as eyes vasculature. Previous studies provide evidence of elevated blood flow velocities (BFv) and volume (BFV) in superior mesenteric artery (SMA). We prospectively studied hemodynamics in feeding arteries of bowel and eyes before and 2weeks after treatment ...
Noizat-Pirenne F - - 2012
Transfusion remains a key treatment in sickle cell disease. The occurrence of a delayed haemolytic transfusion reaction is not rare and is a life-threatening event. The main cause of delayed haemolytic transfusion reaction is production of alloantibodies against red blood cell antigens. The high rate of alloimmunization in sickle cell ...
Jeong Woo Kyoung - - 2012
Objectives- The purpose of this study was to categorize hepatofugal portal venous flow on Doppler sonography after liver transplantation and to investigate its clinical importance and presumed causes based on radiologic and pathologic findings. Methods- This retrospective study was approved by our Institutional Review Board, and the requirement for informed ...
Bird James - - 2012
Transfusion of large amounts of blood products is a complex and changing practice. British and American military experience of the process in Afghanistan and Iraq, and the findings of the international CRASH 2 study (Shakur et al 2010), have led to changes in practice (Moor et al 2009). The procedure ...
Fast Loren D - - 2012
The transfusion of blood products can result in a variety of consequences, including transfer of pathogens and the induction of immune responses, such as the almost invariably fatal transfusion-associated graft-versus-host disease (TA-GVHD). Exposure of blood products to γ-irradiation is currently the standard of care for the prevention of TA-GVHD. Regulatory, ...
Owusu Benjamin Y - - 2012
Nitric oxide (NO) is a key modulator of vascular homeostasis controlling critical functions related to blood flow, respiration, cell death and proliferation, and protecting the vasculature from pro-inflammatory and coagulative stresses. Inhibition of NO formation, and/or diversion of NO away from its physiological signalling targets lead to dysregulated NO bioavailability, ...
Tanhehco Yvette C - - 2012
Prior to the introduction of recombinant human erythropoietin (EPO), red blood cell (RBC) transfusions were frequently required when iron and anabolic steroids failed to improve the clinical symptoms of anemia associated with hemoglobin (Hb) levels that were commonly less than 7 g/dl. After the approval of EPO in the United ...
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