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Markl Michael M Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue Suite 1600, Chicago, IL, 60611, USA, - - 2014
4D flow MRI permits a comprehensive in-vivo assessment of three-directional blood flow within 3-dimensional vascular structures throughout the cardiac cycle. Given the large coverage permitted from a 4D flow acquisition, the distribution of vessel wall and flow parameters along an entire vessel of interest can thus be derived from a ...
Gao Yu-Rong YR 1] Center for Neural Engineering, Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, USA [2] Neuroscience Graduate Program, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, - - 2014
The cross-sectional area of a blood vessel determines its resistance, and thus is a regulator of local blood flow. However, the cross-sections of penetrating vessels in the cortex can be non-circular, and dilation and constriction can change the shape of the vessels. We show that observed vessel shape changes can ...
Cheng Xin X From the Department of Neurology (X.C., Q.D., Y.S.), Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; Haldeman Laboratory of Molecular and Cellular Neurobiology (X.C., P.H., Y.S.), Sun Health Research Institute, Sun City, AZ; Center for Hormone Advanced Science and Education (P.H., R.L.) and Center for Advanced Therapeutic Strategies for Brain Disorders (P.H., Y.S.), Roskamp Institute, Sarasota, FL; and Department of Neurology (Y.S.), University of Florida College of Medicine, - - 2014
A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear. We isolated leptomeningeal vessels from rapidly autopsied brains (the average of postmortem intervals was 3.28 hours) from 9 patients with CAA and 10 age-matched controls, ...
Urbanek A A Department of Invertebrate Zoology and Parasitology, University of Gdansk, Gdansk, - - 2014
The distribution and morphology of antennal sensilla coeloconica in parasitic and predaceous biting midges were studied in females of Forcipomyia (feeding on the blood of frogs), Atrichopogon (feeding on haemolymph), Austroconops, Culicoides (feeding on the blood of birds and mammals) and Brachypogon (feeding on haemolymph and dissolved tissues of insects) ...
Steeden Jennifer A JA UCL Centre for Cardiovascular Imaging, University College London, London, - - 2014
1) To validate an R-R interval averaged golden angle spiral phase contrast magnetic resonance (RAGS PCMR) sequence against conventional cine PCMR for assessment of renal blood flow (RBF) in normal volunteers; and 2) To investigate the effects of motion and heart rate on the accuracy of flow measurements using an ...
Hamner J W JW From the Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, MA (J.W.H., C.O.T.); and Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA - - 2014
Prior work aimed at improving our understanding of human cerebral autoregulation has explored individual physiological mechanisms of autoregulation in isolation, but none has attempted to consolidate the individual roles of these mechanisms into a comprehensive model of the overall cerebral pressure-flow relationship. We retrospectively analyzed this relationship before and after ...
Novielli Nicole M NM Department of Medical Biophysics, Western University, London, Ontario, - - 2014
To investigate the effects of pre-diabetes on microvascular network function in contracting skeletal muscle. We hypothesized that pre-diabetes compromises contraction-evoked vasodilation of branching second-order(2A), third-order(3A), and fourth-order(4A) arterioles, where distal arterioles would be affected the greatest. Intravital video microscopy was used to measure arteriolar diameter (in 2A, 3A, and 4A) ...
Taylor Jennifer L JL Mayo Clinic, United - - 2014
We have previously shown that non-selective cyclooxygenase inhibition, via indomethacin, unfavorably increased central blood pressure in older adults, with little effect in young adults. In addition, the vasoactive prostaglandins have been shown to contribute to both peripheral vasodilator responses and large artery function; however, there is little information available in ...
Hu Xiang X Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha 410081, - - 2014
KCTD10 is a member of the PDIP1 family, which is highly conserved during evolution, sharing a lot of similarities among human, mouse, and zebrafish. Recently, zebrafish KCTD13 has been identified to play an important role in the early development of brain and autism. However, the specific function of KCTD10 remains ...
Sriram Krishna K Department of Mechanical and Aerospace Engineering, University of California, San Diego, - - 2014
We model blood in a microvessel as an inhomogeneous non-Newtonian fluid, whose viscosity varies with hematocrit and shear rate in accordance with the Quemada rheological relation. The flow is assumed to consist of two distinct, immiscible and homogeneous fluid layers: an inner region densely packed with red blood cells, and ...
Zaane F van Leeuwen-van FV Department of Radiation Oncology, Center for Optical Diagnostics and Therapy, Postgraduate School Molecular Medicine,Erasmus MC, P.O. box 2040, 3000 CA Rotterdam, The - - 2014
In a previous study it is shown that for topically applied ALA-PDT, PpIX concentration correlates with vascular changes including vasoconstriction and/or vascular leakage of small vessels and arterioles in the mouse epidermis and dermis. In this study we report on vascular responses induced by ALA-PDT for different fluence rates, including ...
Feuerstein Delphine D Max Planck Institute for Neurological Research, Cologne, - - 2014
Regional cerebral blood flow (rCBF) is spatially and temporally adjusted to local energy needs. This coupling involves dilation of vessels both at the site of metabolite exchange and upstream of the activated region. Deficits in upstream blood supply limit the 'capacity to raise rCBF' in response to functional activation and ...
Rühm Adrian A Laser-Forschungslabor, LIFE-Zentrum, Klinikum der Universität München, Marchioninistr. 23, 81377 München, Germany. Electronic address: - - 2014
Intraoperative blood vessel detection based on intraluminal indocyanin-green (ICG) would allow to minimize the risk of blood vessel perforation during stereotactic brain tumor biopsy. For a fiber-based approach compatible with clinical conditions, the maximum tolerable excitation light power was derived from simulations of the thermal heat load on the tissue. ...
Blanco Pablo J PJ National Laboratory for Scientific Computing, LNCC/MCTI, Av. Getúlio Vargas, 333, Petrópolis, RJ , 25651-075, Brazil, - - 2014
Development of blood flow distribution criteria is a mandatory step toward developing computational models and numerical simulations of the systemic circulation. In the present work, we (i) present a systematic approach based on anatomical and physiological considerations to distribute the blood flow in a 1D anatomically detailed model of the ...
Wain Richard A J RA Department of Plastic & Reconstructive Surgery, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK; School of Computing, Engineering and Physical Sciences, University of Central Lancashire, Fylde Road, Preston, Lancashire PR1 2HE, UK; Department of Plastic & Reconstructive Surgery, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, Lancashire PR2 9HT, UK. Electronic address: - - 2014
This study uses computational fluid dynamics (CFD) to model blood flow through idealised sutured and coupled arterial anastomoses to investigate the affect of each technique on intravascular blood flow. Local flow phenomena are examined in detail to study characteristics that potentially initiate thrombus formation; for example, changes in velocity profile, ...
Swanson Terri A TA 1FUJIFILM VisualSonics, Inc., Toronto, Ontario, - - 2014
Several classes of drugs have been shown to cause drug-induced vascular injury (DIVI) in preclinical toxicity studies. Measurement of blood flow and vessel diameter in numerous vessels and across various tissues by ultrasound imaging has the potential to be a noninvasive translatable biomarker of DIVI. Our objective was to demonstrate ...
Hall Catherine N CN 1] Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK - - 2014
Increases in brain blood flow, evoked by neuronal activity, power neural computation and form the basis of BOLD (blood-oxygen-level-dependent) functional imaging. Whether blood flow is controlled solely by arteriole smooth muscle, or also by capillary pericytes, is controversial. We demonstrate that neuronal activity and the neurotransmitter glutamate evoke the release ...
Mentzer Steven J SJ Room 259, Laboratory of Adaptive and Regenerative Biology, Harvard Medical School, Brigham & Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA, - - 2014
Intussusceptive angiogenesis is a dynamic intravascular process capable of dramatically modifying the structure of the microcirculation. The distinctive structural feature of intussusceptive angiogenesis is the intussusceptive pillar-a cylindrical microstructure that spans the lumen of small vessels and capillaries. The extension of the intussusceptive pillar appears to be a mechanism for ...
Jia Yali Y Casey Eye Institute, Oregon Health & Science University, Portland, - - 2014
To detect and quantify choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography. Observational, cross-sectional study. A total of 5 normal subjects and 5 subjects with neovascular AMD were included. A total of 5 eyes with neovascular AMD and 5 normal age-matched controls ...
Gong Xianghui X Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of - - 2014
Many studies have demonstrated that in vitro shear stress conditioning of endothelial cell-seeded small-diameter vascular grafts can improve cell retention and function. However, the laminar flow and pulsatile flow conditions which are commonly used in vascular tissue engineering and hemodynamic studies are quite different from the actual physiological pulsatile flow which ...
Needham Maurice A MA Queen's University of Belfast, Grosvenor Road, Belfast, BT12 6BA, Northern - - 2014
Purpose: This study tested the role of K(+)- and Cl(-)-channels in retinal arteriolar smooth muscle in the regulation of retinal blood flow. Methods: Studies were carried out in adult Male Hooded Lister rats. Selectivity of ion channel blockers was established using electrophysiological recordings from smooth muscle in isolated arterioles under ...
Iadecola Costantino C Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, - - 2014
The body clears small clots from blood vessels through a process called angiophagy, opening up new approaches to combat cerebral and cardiac microvascular occlusive diseases (Grutzendler et al., this issue).
Grutzendler Jaime J Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, - - 2014
Occlusion of the microvasculature by blood clots, atheromatous fragments, or circulating debris is a frequent phenomenon in most human organs. Emboli are cleared from the microvasculature by hemodynamic pressure and the fibrinolytic system. An alternative mechanism of clearance is angiophagy, in which emboli are engulfed by the endothelium and translocate ...
Hänscheid H H Department of Nuclear Medicine, University of Würzburg, Würzburg, - - 2014
Nuclear medicine dosimetry and research in biodosimetry often require the knowledge of the absorbed dose to the blood. This study provides coefficients for the absorbed dose rates to the blood related to the activity concentration in the blood as a function of the vessel radius for radionuclides commonly used in ...
Nakamachi Eiji E Department of Biomedical Engineering, Doshisha University, 1-3 Tatara-Miyakodani, Kyotanabe, Kyoto, 610-0394, - - 2014
In this study, we developed a multi-scale finite element (FE) analysis code to obtain the stress and strain that occurred in the smooth muscle cell (SMC) at micro-scale, which was seeded in the real fabricated braid fibril artificial blood vessel. This FE code can predict the dynamic response of stress ...
Shaw Vivien - - 2014
The objectives of this research are, first, to establish if the extraordinary acupuncture meridian known as Chōng (), Penetrating Vessel or Sea of Blood, is in essence a description of certain macroscopic parts of the underlying vascular system and, second, by extension, to show that it is likely that cadaveric ...
Mourant Judith R JR Bioscience Division, Los Alamos National Laboratory, Los Alamos, P.O. Box 1663, MS M888, New Mexico - - 2014
ABSTRACT. Tissue vasculature is altered when cancer develops. Consequently, noninvasive methods of monitoring blood vessel size, density, and oxygenation would be valuable. Simple spectroscopy employing fiber optic probes to measure backscattering can potentially determine hemoglobin parameters. However, heterogeneity of blood distribution, the dependence of the tissue-volume-sampled on scattering and absorption, ...
Capron M M Université de Toulouse, INPT-CNRS, Institut de Mécanique des Fluides de Toulouse, Allée du Professeur C. Soula, 31400 Toulouse, - - 2014
The xylem vessels of trees constitute a model natural microfluidic system. In this work, we have studied the mechanism of air flow in the Populus xylem. The vessel microstructure was characterized by optical microscopy, transmission electronic microscopy (TEM), and atomic force microscopy (AFM) at different length scales. The xylem vessels ...
Liu Liehua L Department of Orthopedics, Orthopedics Center of PLA, Chongqing, - - 2014
Various anterior lumbar surgical approaches, including the minimally invasive approach, have greatly improved in recent years. Vascular complications resulting from ALIF are frequently reported. Little information is available about the safety of large blood vessel stretch. We evaluated the right side stretch limit (RSSL) of the abdominal aorta (AAA) and ...
Noh Hyun J HJ Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, - - 2014
Subcortical vascular dementia (SVaD) is a common form of dementia, attributed to ischemic small-vessel disease. Blood viscosity (BV) may contribute to the pathophysiology of SVaD. However, SVaD patients with coexisting amyloid deposition may not show differences in BV because their small-vessel disease may result from amyloid angiopathy independently of BV. ...
Caballero A D AD a Fluid Mechanics Research Group, Energetics and Mechanics Department, Universidad Autónoma de Occidente , Calle 25 No. 115-85, Km 2 Via Cali - Jamundi, Cali , - - 2014
Three non-Newtonian blood viscosity models plus the Newtonian one are analysed for a patient-specific thoracic aorta anatomical model under steady-state flow conditions via wall shear stress (WSS) distribution, non-Newtonian importance factors, blood viscosity and shear rate. All blood viscosity models yield a consistent WSS distribution pattern. The WSS magnitude, however, ...
Paul Anup A Heat Transfer and Thermal Power Laboratory, Department of Mechanical Engineering, IIT Madras, Chennai, Tamilnadu 600036, - - 2014
During laser-assisted photo-thermal therapy, the temperature of the heated tissue region must rise to the therapeutic value (e.g., 43°C) for complete ablation of the target cells. Large blood vessels (larger than 500 micron in diameter) at or near the irradiated tissues have a considerable impact on the transient temperature distribution ...
Nam Kyoung Won KW Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South - - 2014
To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel. A hemostatic clip and its applier that can stanch bleeding while maintaining blood flow through the clipped vessel was introduced, and the performance of the proposed clip was evaluated using ...
Tang Elaine E School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, - - 2014
Total cavopulmonary connection (TCPC) geometries have great variability. Geometric features, such as diameter, connection angle, and distance between vessels, are hypothesized to affect the energetics and flow dynamics within the connection. This study aimed to identify important geometric characteristics that can influence TCPC hemodynamics. Anatomies from 108 consecutive patients were ...
Sobczyk O O Institute of Medical Sciences, University of Toronto, Toronto, - - 2014
Cerebrovascular reactivity (CVR) is the change in cerebral blood flow (CBF) in response to a change in a vasoactive stimulus. Paradoxical reductions in CBF in response to vasodilatory stimulation ('steal') are associated with vascular pathology. However, a pathophysiological interpretation of 'steal' requires a comprehensive conceptual model linking pathology and changes ...
Gommer Erik D ED Department of Clinical Neurophysiology, Maastricht University Medical Centre+, Maastricht, The Netherlands. Electronic address: - - 2014
Visually evoked flow responses recorded using transcranial Doppler ultrasonography are often quantified using a dynamic model of neurovascular coupling. The evoked flow response is seen as the model's response to a visual step input stimulus. However, the continuously active process of dynamic cerebral autoregulation (dCA) compensating cerebral blood flow for ...
Fernandez Cristina E CE Department of Biomedical Engineering, Duke - - 2014
Considerable advances have occurred in the development of tissue-engineered blood vessels (TEBVs) to repair or replace injured blood vessels, or as in vitro systems for drug toxicity testing. Here we summarize approaches to produce TEBVs and review current efforts to (1) identify suitable cell sources for the endothelium and vascular ...
Ortiz Daniel D Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, - - 2014
Blood flow and blood-endothelium interactions correspond with the genesis of cardiovascular diseases. Therefore, quantitative analysis of blood flow dynamics at the microcirculation level is of special interest. Regulatory mechanisms mediated by blow flow have been studied in detail using in vitro approaches. However, these mechanisms have not been fully validated ...
Sun Shenshen - - 2014
Abstract-Computed Aided Diagnosis (CAD) of lung CT data is a new quantitative analysis technique to distinguish malignant nodules from benign ones. Nodule growth rate is a key indicator to discriminate between benign and malignant nodules. Accurate nodule segmentation is the essential for calculating the nodule growth rate. However, it is ...
Doblhoff-Dier Veronika V Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, - - 2014
We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the ...
Niu Guoguang G Wake Forest Institute for Regenerative Medicine, Wake Forest Baptist Medical Center, Medical Center Boulevard , Winston-Salem, NC 27157 , USA +1 336 713 7295 ; +1 336 713 7290 ; - - 2014
Cardiovascular disease (CVD) affecting blood vessel function is a leading cause of death around the world. A common treatment option to replace the diseased blood vessels is vascular grafting using the patient's own blood vessels. However, patients with CVD are usually lacking vessels for grafting. Recent advances in tissue engineering ...
Namgung Bumseok B Department of Biomedical Engineering, National University of Singapore, - - 2014
This study examined how the uneven influx of red blood cells (RBCs) from feeding vessels influences formation of cell-free layer (CFL) in the downstream vessel of a venular bifurcation. Spatio-temporal variations of the CFL width along the downstream vessel (19-41-μm inner diameter, D) were determined at 0.5D intervals from 0.5D ...
Wallace Sean S Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Electronic address: - - 2014
In theory, the power of a trans-cranial Doppler signal may be used to measure changes in blood flow and vessel diameter in addition to velocity. In this study, a flow index (FI) of relative changes in blood flow was derived from frequency-weighted Doppler power signals. The FI, plotted against velocity, ...
Balamuthusamy Saravanan S Angiocare, Vascular and Interventional Nephrology, Tucson, Arizona; Department of Medicine, Nephrology Division, University of Arizona, Tucson, - - 2014
The performance and safety of a new self-centering, split-tip hemodialysis tunneled catheter was compared with a symmetric-tip catheter. The new catheter has a greater separation between the arterial and venous tips, with dual apertures designed to permanently face the center of the blood vessel. The design is intended to improve ...
Restrepo Maria M The Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, - - 2014
Typically, a Fontan connection is constructed as either a lateral tunnel (LT) pathway or an extracardiac (EC) conduit. The LT is formed partially by atrial wall and is assumed to have growth potential, but the extent and nature of LT pathway growth have not been well characterized. A quantitative analysis ...
Told Reinhard R Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Department of Ophthalmology, Medical University of Vienna, Vienna, - - 2014
Pentoxifylline, a nonselective phosphodiesterase inhibitor, shows vasodilator effects in certain vascular beds and reduces blood viscosity. We have previously shown that under states of vasoconstriction an interaction between circulating erythrocytes and leukocytes may play a role in the control of blood flow. The reason for this observation is not entirely ...
Jiang Hong H Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA; Department of Neurology, University of Miami, Miami, FL, USA. Electronic address: - - 2014
To develop, test and validate functional slit lamp biomicroscopy (FSLB) for generating non-invasive bulbar conjunctival microvascular perfusion maps (nMPMs) and assessing morphometry and hemodyanmics. FSLB was adapted from a traditional slit-lamp microscope by attaching a digital camera to image the bulbar conjunctiva to create nMPMs and measure venular blood flow ...
Mishra Anusha A 1] Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. - - 2014
The cerebral circulation is highly specialized, both structurally and functionally, and it provides a fine-tuned supply of oxygen and nutrients to active regions of the brain. Our understanding of blood flow regulation by cerebral arterioles has evolved rapidly. Recent work has opened new avenues in microvascular research; for example, it ...
Schlereth Simona L SL Department of Ophthalmology, University Hospital of Cologne, Kerpenerstr. 62, Cologne, 50924, - - 2014
Purpose: To investigate whether the normal adult human sclera contains lymphatic vessels and to study their relation to immune cells and blood vessel anatomy. Methods: Scleral tissue probes from 35 adult human donor bulbi were analyzed by immunohistochemistry and confocal microscopy for blood vessels (CD31+), lymphatic vessels (LYVE1+, podoplanin+), and ...
Zhai Wanyin W State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, - - 2014
Xenogenic decellularized vessels, mainly composed of extracellular matrices (ECMs), are thought to be one of the alternative resources of small-diameter blood vessels due to abundant source, tubular configuration, vascular microstructure, and good cytocompatibility. However, the main shortcomings of ECM vessels are their low chemical stability, easy calcification, immunogenicity, and high ...
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