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Irish Seth R SR Entomology Branch, Department of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Center for Global Health, Atlanta, GA, - - 2014
The physical integrity of bednets is a concern of national malaria control programs, as it is a key factor in determining the rate of replacement of bednets. It is largely assumed that increased numbers of holes will result in a loss of protection of sleepers from potentially infective bites. Experimental ...
Masilamani Vadivel - - 2014
BackgroundMalaria is the most common disease transmitted by the bite by an infected female anopheles mosquito and caused by the plasmodium parasite. It is mostly prevalent in subtropical regions receiving abundant rain and supporting copious mosquito breeding. This disease is generally detected by the microscopic examination of blood films or ...
Tran Tuan M - - 2014
As public health efforts seek to eradicate malaria, there has been an emphasis on eliminating low-density parasite reservoirs in asymptomatic carriers. As such, diagnosing submicroscopic Plasmodium infections using PCR-based techniques has become important not only in clinical trials of malaria vaccines and therapeutics, but also in active malaria surveillance campaigns. ...
Kumar Ashok A AA School of Engineering and Applied Sciences, Harvard University, 29 Oxford St., Cambridge, MA, 02138, United - - 2014
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood enriched for reticulocytes. AMPS enrich reticulocytes from blood from both ...
Comfort Alison B - - 2014
Blood transfusions can reduce mortality among children with severe malarial anaemia, but there is limited evidence quantifying the relationship between paediatric malaria and blood transfusions. This study explores the extent to which the use of paediatric blood transfusions is affected by the number of paediatric malaria visits and admissions. It ...
Peng Weng Kung WK 1] BioSystems &Micromechanics Interdisciplinary Research Group (IRG), Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore. - - 2014
We report a new technique for sensitive, quantitative and rapid detection of Plasmodium spp.-infected red blood cells (RBCs) by means of magnetic resonance relaxometry (MRR). During the intraerythrocytic cycle, malaria parasites metabolize large amounts of cellular hemoglobin and convert it into hemozoin crystallites. We exploit the relatively large paramagnetic susceptibility ...
Sallum Maria Anice - - 2014
A recent paper in Malaria Journal reported the observation of unexpected prevalence rates of healthy individuals carrying Plasmodium falciparum (5.14%) or Plasmodium vivax (2.26%) DNA among blood donors from the main transfusion centre in the metropolitan Sao Paulo, a non-endemic area for malaria. The article has been challenged by a ...
Mendrone Alfredo A - - 2014
A study searching for Plasmodium vivax and Plasmodium falciparum DNA among blood donors from the non-endemic area in Brazil reported a rate of 7.41%. This number is at least three times higher than what has been observed in blood donors from the Amazon, an endemic area concentrating >99% of all ...
Oliver Shüné V - - 2014
Anopheles arabiensis is a major malaria vector in Africa. Adult females are likely to imbibe multiple blood meals during their lifetime. This results in regular exposure to potential toxins and blood-meal induced oxidative stress. Defence responses to these stressors may affect other factors of epidemiological significance, such as insecticide resistance ...
Atkinson Greg G Health and Social Care Institute, School of Health & Social Care, Parkside West, Teesside University, Middlesbrough, Tees Valley TS1 3BA, - - 2014
A ratio index (FMD%) is used ubiquitously to scale (by simple division) brachial artery flow-mediated dilation (Ddiff) in direct proportion to baseline diameter (Dbase). It is now known that Ddiff is inversely proportional to Dbase rendering FMD% wholly inappropriate. Consequently, FMD% is still substantially dependent on Dbase. Although this problem ...
Mohamied Yumnah Y Department of Bioengineering, Imperial College London, London, SW7 2AZ, - - 2014
The non-uniform distribution of atherosclerosis within the arterial system has been attributed to pro-atherogenic influences of low, oscillatory haemodynamic wall shear stress (WSS) on endothelial cells (EC). This theory is challenged by the changes in lesion location that occur with age in human and rabbit aortas. Furthermore, a number of ...
Kornfield Tess E TE Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota - - 2014
Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional hyperemia. We have characterized blood flow regulation in the rat ...
Anjomruz Mehdi M Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. P.O. BOX: 14155-6446, - - 2014
Recent epidemiological evidences revealed a higher rate of O blood group in the residents of malaria-endemic areas suggesting that groups A, B, and AB associated with a higher disease severity and fatality. Also recent data showed the low prevalence of AB group within the malaria-endemic residents in south of Iran ...
Kawada Hitoshi - - 2014
Since the World Health Organization (WHO) adopted the use of long-lasting insecticidal nets (LLINs) as a principal strategy for effective malaria prevention and control, pyrethroids have been the only class of insecticides used for LLINs. The dramatic success of insecticide-treated nets (ITNs) and LLINs in African countries, however, has been ...
Elhanan Tal - - 2014
Spectrally encoded flow cytometry (SEFC) is a promising technique for imaging blood in the microcirculation. Yet, the dependency of one of the axes of the image on time prevents effective quantification of essential clinical parameters. Here, we address this challenge by splitting the optical path in an SEFC system into ...
Zhang Jing J Department of Nursing, Bengbu Medical College, Bengbu, - - 2014
To establish a model to simulate the clinical specific process of peripherally inserted central catheter (PICC) on rabbits, and detect how long the catheter can be indwelled. Seventeen healthy New Zealand white rabbits were inserted the PICC according to the clinical specific procedure. With the principle of random, the rabbits ...
Carvalho Leonardo José de Moura LJ Laboratório de Pesquisas em Malária, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, - - 2014
Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised ...
Kowallick Johannes Tammo JT Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, - - 2014
Objective: Real-time phase-contrast flow magnetic resonance imaging (MRI) at high spatiotemporal resolution was applied to simultaneously evaluate haemodynamic functions in the ascending aorta and superior vena cava during elevated intrathoracic pressure (Valsalva manoeuvre). Methods: Real-time phase-contrast flow MRI at 3 T was based on highly undersampled radial gradient-echo acquisitions and ...
Rothmayer A P AP Department of Aerospace Engineering, Iowa State University, Ames, IA 5011-2271, USA - - 2014
Magnetohydrodynamic flow of an incompressible fluid through a plane channel with slowly varying walls and a magnetic field applied transverse to the channel is investigated in the high Reynolds number limit. It is found that the magnetic field can first influence the hydrodynamic flow when the Hartmann number reaches a ...
Thompson Emilia B EB a School of Sport, Exercise and Health Sciences , Loughborough University , Loughborough , - - 2014
Abstract Rock climbers perform repeated isometric forearm muscle contractions subjecting the vasculature to repeated ischaemia and distorted haemodynamic signals. This study investigated forearm vascular characteristics in rock climbers compared to healthy untrained controls. Eight climbers (CLIMB) (BMI; 22.3, s = 2.0 kg/m(2), isometric handgrip strength; 46, s = 8 kg) ...
Pohlmann Andreas A Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, - - 2014
Cerebrovascular abnormality is frequently accompanied by cognitive dysfunctions, such as dementia. Antibodies against the α1 -adrenoceptor (α1 -AR) can be found in patients with Alzheimer's disease with cerebrovascular disease, and have been shown to affect the larger vessels of the brain in rodents. However, the impact of α1 -AR antibodies ...
Jullienne Amandine A Department of Pediatrics, Loma Linda University, Loma Linda, California, - - 2014
In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (Aβ) accumulation. We investigated NVU changes for up to 6 ...
Tanifum Eric A EA The Singleton Department of Pediatric Radiology, Texas Childrens Hospital, Houston, Texas, - - 2014
In Alzheimer's disease (AD), there is increasing evidence of blood-brain barrier (BBB) compromise, usually observed as 'microbleeds' correlated with amyloid plaque deposition and apoE-ɛ4 status, raising the possibility of nanotherapeutic delivery. Molecular probes have been used to study neurovascular leak, but this approach does not adequately estimate vascular permeability of ...
Wagenfeld Lars L Department of Ophthalmology, University Medical Center Eppendorf, Martinistr. 52, Hamburg, 20246, Germany - - 2014
Purpose: Glaucoma is associated with an altered blood flow and increased levels of reactive oxygen species (ROS). ROS can have opposing influences on the tone of a vessel; depending on the condition and type of the vessel, ROS can induce vasodilation or vasoconstriction. In the present study we investigated the ...
Ajioka Itsuki I Tokyo Medical and Dental University, Tokyo, Japan ; - - 2014
After brain injury, neuroblasts generated from endogenous neural stem cells migrate toward the injured site using blood vessels as a scaffold, raising the possibility of reconstructing blood vessel-network scaffolds as a strategy for promoting endogenous neuronal regeneration. Here, we designed biomaterials based on the components and morphology of blood vessel ...
Barfett Joseph John JJ Department of Medical Imaging, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada, - - 2014
We examine a time of flight (TOF) approach for the analysis of contrast enhanced 4D volumetric CT angiography scans to derive and display blood velocity in arteries. Software was written to divide blood vessels into a series of cross sections and to track contrast bolus TOF along the central vessel ...
Biswas Shivhare Sourima S Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, - - 2014
How does the smooth muscle content and differentiation stage of vascular smooth muscle cells (VSMCs) in endometrial blood vessels change according to the different phases of the menstrual cycle and is this altered in women with menorrhagia? The smooth muscle content (as a proportion of the vascular cross-sectional area) of ...
Fumagalli Stefano S IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, via La Masa 19, 20156 Milan, Italy; Neurosurgical Intensive Care Unit, Fondazione IRCCS Ca' Granda/Ospedale Maggiore Policlinico, Via Francesco Sforza 28, 20122 Milan, Italy. Electronic address: - - 2014
The cerebral vasculature has a unique role in providing a constant supply of oxygen and nutrients to ensure normal brain functions. Blood vessels that feed the brain are far from being simply channels for passive transportation of fluids. They form complex structures made up of different cell types. These structures ...
Navarro R R Neurosurgery, Stanford University, Palo Alto, CA, - - 2014
Moyamoya disease and syndrome are well known to affect the anterior cerebral circulation by progressive steno-occlusive disease of the supraclinoid internal carotid arteries. Less attention has been paid to changes in posterior arterial circulation hemodynamics in this condition. We sought to better understand the latter using a relatively novel noninvasive ...
König Franziska F Department of Aerodynamics and Fluid Mechanics, BTU Cottbus, 03046 Cottbus, - - 2014
The CoLaPipe is a novel test facility at the Department of Aerodynamics and Fluid Mechanics, Brandenburg University of Technology Cottbus-Senftenberg (BTU Cottbus-Senftenberg), set up to investigate fully developed pipe flow at high Reynolds numbers (Rem ⩽ 1.5 × 10(6)). The design of the CoLaPipe is closed-return with two available test ...
Shin Hyun Joo HJ Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, - - 2014
To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high ...
van der Merwe Elizabeth L EL Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925 Cape Town, South Africa. Electronic address: - - 2014
The mouse eye has been used as a model for studies on the microanatomy of the outflow pathways but most of what is known comes from histological sections. These studies have focused mainly on the morphological features of the trabecular meshwork, Schlemm's canal and aqueous channels that link to the ...
Yiu Billy Y S BY Medical Engineering Program, University of Hong Kong, Pokfulam, Hong - - 2014
Achieving non-invasive, accurate and time-resolved imaging of vascular flow with spatiotemporal fluctuations is well acknowledged to be an ongoing challenge. In this article, we present a new ultrasound-based framework called vector projectile imaging (VPI) that can dynamically render complex flow patterns over an imaging view at millisecond time resolution. VPI ...
Kapsokalyvas Dimitrios D European Laboratory for Non-Linear Spectroscopy (LENS) University of Florence, Sesto-Fiorentino, 50019, - - 2014
Psoriasis is a skin autoimmune disease characterized by hyperkeratosis, hyperproliferation of the epidermis and dilatation of dermal papillary blood vessels. Healthy skin (5 volunteers) and psoriatic lesions (3 patients) were visualized in vivo, with high contrast and resolution, with a Polarization Multispectral Dermoscope and a Multiphoton Microscope. Psoriatic features were ...
Ghata Narugopal N Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, 95616, - - 2014
Optical techniques including fluorescence lifetime spectroscopy has demonstrated potential as a tool for study and diagnosis of arterial vessel pathologies. However, their application in the intravascular diagnostic procedures has been hampered by the presence of blood hemoglobin that affects the light delivery to and the collection from the vessel wall. ...
Cuddapah Vishnu Anand VA Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 35294, - - 2014
Malignant gliomas are devastating tumours that frequently kill patients within 1 year of diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape complete surgical resection and chemo- and radiation therapy. Gliomas use the same tortuous extracellular routes of migration that are travelled by immature ...
Giese Daniel - - 2014
The clinical applicability of time-resolved 3D flow cardiovascular magnetic resonance (CMR) remains compromised by the long scan times associated with phase-contrast imaging. The present work demonstrates the applicability of 8-fold acceleration of Cartesian time-resolved 3D flow CMR in 10 volunteers and in 9 patients with different congenital heart diseases (CHD). ...
Maude Richard J RJ Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok, Thailand; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom; Global Health Division, Menzies School of Health Research and Charles Darwin University, Casuarina, Northern Territory, Australia; Ispat General Hospital, Rourkela, Orissa, India - - 2014
Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of ...
Prozorowska Ewelina E Department of Histology and Embryology, Poznań University of Life Sciences, Wojska Polskiego 71C, 60-625, Poznań, - - 2014
The study focused on the description of pig gallbladder angioarchitecture, with particular emphasis on the specifics of the course of blood vessels in individual layers of the gallbladder wall. Furthermore, the vascular systems of the pig gallbladder were analyzed in terms of the adaptation of this organ to changes in ...
Rymer Christopher C Children's Hospital of - - 2014
During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. Here, we investigate the regulatory role of renal blood flow and oxygen concentration on nephron progenitor differentiation during ontogeny. To ...
Turturici M M Department of Neuroscience, University of Torino, Torino, Italy. - - 2014
Aim of the present study is to investigate the role of mechano-sensitive channels on basal muscle blood flow and on the compression-induced rapid hyperaemia. To this aim, the mechano-sensitive channel blocker Gadolinium (Gd(3+)) is employed, which already proved to reduce the myogenic response in isolated vessels. Muscle blood flow (MaBF) ...
Shiga Yukihiro Y Tohoku University, Sendai, 980-8574, - - 2014
Purpose:To investigate the accuracy and reproducibility of relative flow volume (RFV), a novel index of blood flow in the human retina derived from laser speckle flowgraphy (LSFG). Methods:Pre- and post-branch retinal RFV measurements were compared in 34 retinal venous bifurcations in 34 healthy volunteers (mean age: 49.0 ± 14.8 years) ...
Wang Kuei-Chun KC From the Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La - - 2014
The site-specificity of endothelial phenotype is attributable to the local hemodynamic forces. The flow regulation of microRNAs in endothelial cells (ECs) plays a significant role in vascular homeostasis and diseases. The objective of this study was to elucidate the molecular mechanism by which the pulsatile shear flow-induced microRNA-23b (miR-23b) exerts ...
Tajima Yosuke Y 1] Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan [2] Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, - - 2014
This study aimed to examine the cortical microvessel diameter response to hypercapnia in misery perfusion using two-photon laser scanning microscopy (TPLSM). We evaluated whether the vascular response to hypercapnia could represent the cerebrovascular reserve. Cerebral blood flow (CBF) during normocapnia and hypercapnia was measured by laser-Doppler flowmetry through cranial windows ...
Martorell Jordi J Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA Department. of Chemical Engineering, IQS School of Engineering, URL, Barcelona, Spain - - 2014
Atherogenesis, evolution of plaque and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multi-scale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow and structural conditions may help understand the progression of occlusive arterial disease, providing insight into how ...
Jiang Hong H Department of Electrophysiology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China. Electronic address: - - 2014
Multiple sclerosis (MS) is characterized by perivascular inflammatory infiltration, secondary demyelination, and axonal loss in the central nervous system. Angiopoietin-1 (Ang-1) constitutes a family of endothelial growth factors that can inhibit MS-associated, inflammation-induced blood vascular leakage and lessen increased blood vessel permeability. This study was designed to investigate the effects ...
Romanini Laura L Department of Radiology, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy. Electronic address: - - 2014
To evaluate the accuracy of quantitative analysis of bowel wall enhancement in inflammatory bowel disease (IBD) with contrast enhanced ultrasound (CEUS) by comparing the results with vascular density in a biopsy sample from the same area of the intestinal tract, and to determine the usefulness of this analysis for the ...
Trexler Eric T ET Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2014
Recent research has shown that dietary nitrate has favorable effects on blood flow and exercise performance. The purpose of this randomized, double-blind, placebo-controlled crossover study was to investigate the acute effects of pomegranate extract on blood flow, vessel diameter, and exercise performance in active individuals. Nineteen men and women (mean ...
Wen Jun J #Department of Applied Mechanics, Sichuan University, Chengdu, 610065, - - 2014
Early researches on the artery bypass graft (ABG) generally took the assumption of rigid vessel wall which ignored the wall compliancy. To obtain more realistic and physiological hemodynamic parameters, a fluid structure interaction (FSI) study on a complete ABG was carried out. It was concluded: 1) a compliant vessel is ...
Zivadinovic Biljana - - 2014
Auditory evoked potentials (AEP) represent an electrophysiological method used in the diagnostics of pathological changes of the brainstem. Patients with vertebrobasilar insufficiency (VBI) show changes in the AEP-caused ischemia of the brain structures that generate their responses. The aim of the study was to determine the diagnostic significance and correlation ...
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