Search Results
Results 1 - 50 of 1286
1 2 3 4 5 6 7 8 9 10 >
Elhanan Tal - - 2014
Spectrally encoded flow cytometry (SEFC) is a promising technique for imaging blood in the microcirculation. Yet, the dependency of one of the axes of the image on time prevents effective quantification of essential clinical parameters. Here, we address this challenge by splitting the optical path in an SEFC system into ...
Kowallick Johannes Tammo JT Institute for Diagnostic and Interventional Radiology, Heart Center, University Medical Center Göttingen, - - 2014
Objective: Real-time phase-contrast flow magnetic resonance imaging (MRI) at high spatiotemporal resolution was applied to simultaneously evaluate haemodynamic functions in the ascending aorta and superior vena cava during elevated intrathoracic pressure (Valsalva manoeuvre). Methods: Real-time phase-contrast flow MRI at 3 T was based on highly undersampled radial gradient-echo acquisitions and ...
Rothmayer A P AP Department of Aerospace Engineering, Iowa State University, Ames, IA 5011-2271, USA - - 2014
Magnetohydrodynamic flow of an incompressible fluid through a plane channel with slowly varying walls and a magnetic field applied transverse to the channel is investigated in the high Reynolds number limit. It is found that the magnetic field can first influence the hydrodynamic flow when the Hartmann number reaches a ...
Thompson Emilia B EB a School of Sport, Exercise and Health Sciences , Loughborough University , Loughborough , - - 2014
Abstract Rock climbers perform repeated isometric forearm muscle contractions subjecting the vasculature to repeated ischaemia and distorted haemodynamic signals. This study investigated forearm vascular characteristics in rock climbers compared to healthy untrained controls. Eight climbers (CLIMB) (BMI; 22.3, s = 2.0 kg/m(2), isometric handgrip strength; 46, s = 8 kg) ...
Pohlmann Andreas A Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, - - 2014
Cerebrovascular abnormality is frequently accompanied by cognitive dysfunctions, such as dementia. Antibodies against the α1 -adrenoceptor (α1 -AR) can be found in patients with Alzheimer's disease with cerebrovascular disease, and have been shown to affect the larger vessels of the brain in rodents. However, the impact of α1 -AR antibodies ...
Jullienne Amandine A Department of Pediatrics, Loma Linda University, Loma Linda, California, - - 2014
In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (Aβ) accumulation. We investigated NVU changes for up to 6 ...
Tanifum Eric A EA The Singleton Department of Pediatric Radiology, Texas Childrens Hospital, Houston, Texas, - - 2014
In Alzheimer's disease (AD), there is increasing evidence of blood-brain barrier (BBB) compromise, usually observed as 'microbleeds' correlated with amyloid plaque deposition and apoE-ɛ4 status, raising the possibility of nanotherapeutic delivery. Molecular probes have been used to study neurovascular leak, but this approach does not adequately estimate vascular permeability of ...
Wagenfeld Lars L Department of Ophthalmology, University Medical Center Eppendorf, Martinistr. 52, Hamburg, 20246, Germany - - 2014
Purpose: Glaucoma is associated with an altered blood flow and increased levels of reactive oxygen species (ROS). ROS can have opposing influences on the tone of a vessel; depending on the condition and type of the vessel, ROS can induce vasodilation or vasoconstriction. In the present study we investigated the ...
Ajioka Itsuki I Tokyo Medical and Dental University, Tokyo, Japan ; - - 2014
After brain injury, neuroblasts generated from endogenous neural stem cells migrate toward the injured site using blood vessels as a scaffold, raising the possibility of reconstructing blood vessel-network scaffolds as a strategy for promoting endogenous neuronal regeneration. Here, we designed biomaterials based on the components and morphology of blood vessel ...
Barfett Joseph John JJ Department of Medical Imaging, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada, - - 2014
We examine a time of flight (TOF) approach for the analysis of contrast enhanced 4D volumetric CT angiography scans to derive and display blood velocity in arteries. Software was written to divide blood vessels into a series of cross sections and to track contrast bolus TOF along the central vessel ...
Biswas Shivhare Sourima S Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, - - 2014
How does the smooth muscle content and differentiation stage of vascular smooth muscle cells (VSMCs) in endometrial blood vessels change according to the different phases of the menstrual cycle and is this altered in women with menorrhagia? The smooth muscle content (as a proportion of the vascular cross-sectional area) of ...
Fumagalli Stefano S IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, via La Masa 19, 20156 Milan, Italy; Neurosurgical Intensive Care Unit, Fondazione IRCCS Ca' Granda/Ospedale Maggiore Policlinico, Via Francesco Sforza 28, 20122 Milan, Italy. Electronic address: - - 2014
The cerebral vasculature has a unique role in providing a constant supply of oxygen and nutrients to ensure normal brain functions. Blood vessels that feed the brain are far from being simply channels for passive transportation of fluids. They form complex structures made up of different cell types. These structures ...
Navarro R R Neurosurgery, Stanford University, Palo Alto, CA, - - 2014
Moyamoya disease and syndrome are well known to affect the anterior cerebral circulation by progressive steno-occlusive disease of the supraclinoid internal carotid arteries. Less attention has been paid to changes in posterior arterial circulation hemodynamics in this condition. We sought to better understand the latter using a relatively novel noninvasive ...
König Franziska F Department of Aerodynamics and Fluid Mechanics, BTU Cottbus, 03046 Cottbus, - - 2014
The CoLaPipe is a novel test facility at the Department of Aerodynamics and Fluid Mechanics, Brandenburg University of Technology Cottbus-Senftenberg (BTU Cottbus-Senftenberg), set up to investigate fully developed pipe flow at high Reynolds numbers (Rem ⩽ 1.5 × 10(6)). The design of the CoLaPipe is closed-return with two available test ...
Shin Hyun Joo HJ Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University, College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, - - 2014
To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high ...
van der Merwe Elizabeth L EL Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925 Cape Town, South Africa. Electronic address: - - 2014
The mouse eye has been used as a model for studies on the microanatomy of the outflow pathways but most of what is known comes from histological sections. These studies have focused mainly on the morphological features of the trabecular meshwork, Schlemm's canal and aqueous channels that link to the ...
Yiu Billy Y S BY Medical Engineering Program, University of Hong Kong, Pokfulam, Hong - - 2014
Achieving non-invasive, accurate and time-resolved imaging of vascular flow with spatiotemporal fluctuations is well acknowledged to be an ongoing challenge. In this article, we present a new ultrasound-based framework called vector projectile imaging (VPI) that can dynamically render complex flow patterns over an imaging view at millisecond time resolution. VPI ...
Kapsokalyvas Dimitrios D European Laboratory for Non-Linear Spectroscopy (LENS) University of Florence, Sesto-Fiorentino, 50019, - - 2014
Psoriasis is a skin autoimmune disease characterized by hyperkeratosis, hyperproliferation of the epidermis and dilatation of dermal papillary blood vessels. Healthy skin (5 volunteers) and psoriatic lesions (3 patients) were visualized in vivo, with high contrast and resolution, with a Polarization Multispectral Dermoscope and a Multiphoton Microscope. Psoriatic features were ...
Ghata Narugopal N Department of Mechanical and Aerospace Engineering, University of California, Davis, CA, 95616, - - 2014
Optical techniques including fluorescence lifetime spectroscopy has demonstrated potential as a tool for study and diagnosis of arterial vessel pathologies. However, their application in the intravascular diagnostic procedures has been hampered by the presence of blood hemoglobin that affects the light delivery to and the collection from the vessel wall. ...
Cuddapah Vishnu Anand VA Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 425, Birmingham, Alabama 35294, - - 2014
Malignant gliomas are devastating tumours that frequently kill patients within 1 year of diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape complete surgical resection and chemo- and radiation therapy. Gliomas use the same tortuous extracellular routes of migration that are travelled by immature ...
Giese Daniel - - 2014
The clinical applicability of time-resolved 3D flow cardiovascular magnetic resonance (CMR) remains compromised by the long scan times associated with phase-contrast imaging. The present work demonstrates the applicability of 8-fold acceleration of Cartesian time-resolved 3D flow CMR in 10 volunteers and in 9 patients with different congenital heart diseases (CHD). ...
Maude Richard J RJ Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok, Thailand; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom; Global Health Division, Menzies School of Health Research and Charles Darwin University, Casuarina, Northern Territory, Australia; Ispat General Hospital, Rourkela, Orissa, India - - 2014
Malarial retinopathy allows detailed study of central nervous system vascular pathology in living patients with severe malaria. An adult with cerebral malaria is described who had prominent retinal whitening with corresponding retinal microvascular obstruction, vessel dilatation, increased vascular tortuosity, and blood retinal barrier leakage with decreased visual acuity, all of ...
Prozorowska Ewelina E Department of Histology and Embryology, Poznań University of Life Sciences, Wojska Polskiego 71C, 60-625, Poznań, - - 2014
The study focused on the description of pig gallbladder angioarchitecture, with particular emphasis on the specifics of the course of blood vessels in individual layers of the gallbladder wall. Furthermore, the vascular systems of the pig gallbladder were analyzed in terms of the adaptation of this organ to changes in ...
Rymer Christopher C Children's Hospital of - - 2014
During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. Here, we investigate the regulatory role of renal blood flow and oxygen concentration on nephron progenitor differentiation during ontogeny. To ...
Turturici M M Department of Neuroscience, University of Torino, Torino, Italy. - - 2014
Aim of the present study is to investigate the role of mechano-sensitive channels on basal muscle blood flow and on the compression-induced rapid hyperaemia. To this aim, the mechano-sensitive channel blocker Gadolinium (Gd(3+)) is employed, which already proved to reduce the myogenic response in isolated vessels. Muscle blood flow (MaBF) ...
Shiga Yukihiro Y Tohoku University, Sendai, 980-8574, - - 2014
Purpose:To investigate the accuracy and reproducibility of relative flow volume (RFV), a novel index of blood flow in the human retina derived from laser speckle flowgraphy (LSFG). Methods:Pre- and post-branch retinal RFV measurements were compared in 34 retinal venous bifurcations in 34 healthy volunteers (mean age: 49.0 ± 14.8 years) ...
Wang Kuei-Chun KC From the Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La - - 2014
The site-specificity of endothelial phenotype is attributable to the local hemodynamic forces. The flow regulation of microRNAs in endothelial cells (ECs) plays a significant role in vascular homeostasis and diseases. The objective of this study was to elucidate the molecular mechanism by which the pulsatile shear flow-induced microRNA-23b (miR-23b) exerts ...
Tajima Yosuke Y 1] Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan [2] Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, - - 2014
This study aimed to examine the cortical microvessel diameter response to hypercapnia in misery perfusion using two-photon laser scanning microscopy (TPLSM). We evaluated whether the vascular response to hypercapnia could represent the cerebrovascular reserve. Cerebral blood flow (CBF) during normocapnia and hypercapnia was measured by laser-Doppler flowmetry through cranial windows ...
Martorell Jordi J Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, USA Department. of Chemical Engineering, IQS School of Engineering, URL, Barcelona, Spain - - 2014
Atherogenesis, evolution of plaque and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multi-scale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow and structural conditions may help understand the progression of occlusive arterial disease, providing insight into how ...
Jiang Hong H Department of Electrophysiology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China. Electronic address: - - 2014
Multiple sclerosis (MS) is characterized by perivascular inflammatory infiltration, secondary demyelination, and axonal loss in the central nervous system. Angiopoietin-1 (Ang-1) constitutes a family of endothelial growth factors that can inhibit MS-associated, inflammation-induced blood vascular leakage and lessen increased blood vessel permeability. This study was designed to investigate the effects ...
Romanini Laura L Department of Radiology, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123 Brescia, Italy. Electronic address: - - 2014
To evaluate the accuracy of quantitative analysis of bowel wall enhancement in inflammatory bowel disease (IBD) with contrast enhanced ultrasound (CEUS) by comparing the results with vascular density in a biopsy sample from the same area of the intestinal tract, and to determine the usefulness of this analysis for the ...
Trexler Eric T ET Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2014
Recent research has shown that dietary nitrate has favorable effects on blood flow and exercise performance. The purpose of this randomized, double-blind, placebo-controlled crossover study was to investigate the acute effects of pomegranate extract on blood flow, vessel diameter, and exercise performance in active individuals. Nineteen men and women (mean ...
Wen Jun J #Department of Applied Mechanics, Sichuan University, Chengdu, 610065, - - 2014
Early researches on the artery bypass graft (ABG) generally took the assumption of rigid vessel wall which ignored the wall compliancy. To obtain more realistic and physiological hemodynamic parameters, a fluid structure interaction (FSI) study on a complete ABG was carried out. It was concluded: 1) a compliant vessel is ...
Zivadinovic Biljana - - 2014
Auditory evoked potentials (AEP) represent an electrophysiological method used in the diagnostics of pathological changes of the brainstem. Patients with vertebrobasilar insufficiency (VBI) show changes in the AEP-caused ischemia of the brain structures that generate their responses. The aim of the study was to determine the diagnostic significance and correlation ...
Haq Naveed Ul NU Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi - - 2014
Venous stenosis and/or presence of accessory vein (av) are the two most common causes of early fistula failure. While treatment of stenosis is better defined, there are no clear criteria for obliteration of the av. Often, interventionalists rely on visual assessment of flow through the av and its diameter (significant ...
Petersen Sandra M - - 2014
Since analysis of Sidestream Dark Field images still requires subjective interpretation, we wanted to determine intra-observer repeatability and to estimate the correlation between different evaluation methods. Fifty-four Sidestream Dark Field videos were analyzed twice by the same blinded observer using validated software. Vessels were detected, generating the parameter Total Vessel ...
Markl Michael M Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N. Michigan Avenue Suite 1600, Chicago, IL, 60611, USA, - - 2014
4D flow MRI permits a comprehensive in-vivo assessment of three-directional blood flow within 3-dimensional vascular structures throughout the cardiac cycle. Given the large coverage permitted from a 4D flow acquisition, the distribution of vessel wall and flow parameters along an entire vessel of interest can thus be derived from a ...
Stevens Robert D RD 1] Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [3] Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [4] Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, - - 2014
Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor ...
Hecht Nils N Department of Neurosurgery and Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Berlin, - - 2014
Surgical flow augmentation for treatment of cerebral hemodynamic impairment remains controversial. Here, we investigated the benefit of endothelial progenitor cell (EPC) treatment in a rat model of chronic cerebral hypoperfusion. At repeated time points after 3-vessel occlusion (3-VO), animals were treated with 1 × 10(6) DiI-labeled (a) ex vivo-expanded embryonic-EPC ...
Qian Ming - - 2014
This study aims to experimentally investigate the impact of vessel stiffness on the flow dynamics of pulsatile vascular flow. Vessel phantoms with elastic walls were fabricated using polyvinyl alcohol cryogel to result in stiffness ranging from 60.9 to 310.3 kPa and tested with pulsatile flows using a flow circulation set-up. ...
Park Laibaik L From the Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY (L.P., K.K., S.E.J., P.Z., C.I.); Department of Neurosurgery, Stony Brook University, NY (M.L.P., W.E.V.N.); and McLaughlin Research Institute, Great Falls, MT - - 2014
Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease. However, the functional correlates of the vascular pathology induced by cerebral amyloid angiopathy and the mechanisms involved have not been fully established. We used male ...
Shi Xiaorui X Oregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland, OR, USA. Electronic address: - - 2014
Normal microvessel structure and function in the cochlea is essential for maintaining the ionic and metabolic homeostasis required for hearing function. Abnormal cochlear microcirculation has long been considered an etiologic factor in hearing disorders. A better understanding of cochlear blood flow (CoBF) will enable more effective amelioration of hearing disorders ...
Vallon Mario M Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, CCSR 3100, Stanford, CA, 94305, USA, - - 2014
Angiogenesis, the formation of new blood vessels from pre-existing vessels, in the central nervous system (CNS) is seen both as a normal physiological response as well as a pathological step in disease progression. Formation of the blood-brain barrier (BBB) is an essential step in physiological CNS angiogenesis. The BBB is ...
Gunin Andrei G AG Department of Obstetrics and Gynecology, Medical School Chuvash State University, Cheboksary, Russia. Electronic address: - - 2014
Present research is aimed to examine the number of dermal blood vessels, vascular endothelial growth factor (VEGF), delta-like ligand 4(Dll4) and Jagged-1 (Jag-1) in dermal blood vessels of human from 20weeks of pregnancy to 85years old. Numbers and proliferative activity of dermal fibroblast-like cells were also examined. Blood vessels were ...
Lloyd Mark C - - 2014
Breast carcinoma can be classified as either Estrogen Receptor (ER) positive or negative by immunohistochemical phenotyping, although ER expression may vary from 1 to 100% of malignant cells within an ER + tumor. This is similar to genetic variability observed in other tumor types and is generally viewed as a ...
Faraco Carlos C CC Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, - - 2014
Blood oxygenation level-dependent (BOLD)-weighted and vessel-encoded arterial spin labeling (VE-ASL) MRI provide complementary information and can be used in sequence to gauge hemodynamic contributions to cerebrovascular reactivity. Here, cerebrovascular reactivity is assessed using dual echo VE-ASL MRI to understand how VE labeling preparations influence BOLD and ASL contrast in flow-limited ...
Gao Yu-Rong YR 1] Center for Neural Engineering, Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, USA [2] Neuroscience Graduate Program, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, - - 2014
The cross-sectional area of a blood vessel determines its resistance, and thus is a regulator of local blood flow. However, the cross-sections of penetrating vessels in the cortex can be non-circular, and dilation and constriction can change the shape of the vessels. We show that observed vessel shape changes can ...
Cheng Xin X From the Department of Neurology (X.C., Q.D., Y.S.), Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China; Haldeman Laboratory of Molecular and Cellular Neurobiology (X.C., P.H., Y.S.), Sun Health Research Institute, Sun City, AZ; Center for Hormone Advanced Science and Education (P.H., R.L.) and Center for Advanced Therapeutic Strategies for Brain Disorders (P.H., Y.S.), Roskamp Institute, Sarasota, FL; and Department of Neurology (Y.S.), University of Florida College of Medicine, - - 2014
A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear. We isolated leptomeningeal vessels from rapidly autopsied brains (the average of postmortem intervals was 3.28 hours) from 9 patients with CAA and 10 age-matched controls, ...
Huber Laurentius L Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Electronic address: - - 2014
Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses ...
Urbanek A A Department of Invertebrate Zoology and Parasitology, University of Gdansk, Gdansk, - - 2014
The distribution and morphology of antennal sensilla coeloconica in parasitic and predaceous biting midges were studied in females of Forcipomyia (feeding on the blood of frogs), Atrichopogon (feeding on haemolymph), Austroconops, Culicoides (feeding on the blood of birds and mammals) and Brachypogon (feeding on haemolymph and dissolved tissues of insects) ...
1 2 3 4 5 6 7 8 9 10 >