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Bennett-Guerrero Elliott E Duke Clinical Research Institute, Duke University, Durham, North - - 2014
Pretransfusion washing of red blood cells (RBCs) stored for a longer duration may have theoretical advantages but few data exist to support this practice. In many hospital settings, use of a point-of-care cell washer could conceivably be used to quickly wash allogeneic RBCs before transfusion. The purpose of this preliminary ...
Aznaveh Nahid Babaei NB Département de Chimie, Université Laval, 1045 Avenue de la Médecine, Québec, QC G1V 0A6, Canada. - - 2014
We present a microfluidic device capable of patterning linear biofilm formations using a flow templating approach. We describe the design considerations and fabrication methodology of a two level flow-templating micro-bioreactor (FT-μBR), which generates a biofilm growth stream surrounded on 3 sides by a growth inhibiting confinement stream. Through a combination ...
Rochow Niels N Division of Neonatology, Department of Pediatrics, McMaster University, Hamilton, Ontario, - - 2014
A miniaturized oxygenator device that is perfused like an artificial placenta via the umbilical vessels may have significant potential to save the lives of newborns with respiratory insufficiency. Recently we presented the concept of an integrated modular lung assist device (LAD) that consists of stacked microfluidic single oxygenator units (SOUs) ...
- - 2014
This revision is intended to update the 1994 ICSH guidelines. It is based on those guidelines but is updated to include new methods, such as digital image analysis for blood cells, a flow cytometric method intended to replace the reference manual 400 cell differential, and numerous new cell indices not ...
Chen Chengpeng C Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA. - - 2014
A fluidic device constructed with a 3D-printer can be used to investigate stored blood components with subsequent high-throughput calibration and readout with a standard plate reader.
Pfenniger Alois A ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland; Engineering and Information Technology, Bern University of Applied Sciences, Biel, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, - - 2014
Replacement intervals of implantable medical devices are commonly dictated by battery life. Therefore, intracorporeal energy harvesting has the potential to reduce the number of surgical interventions by extending the life cycle of active devices. Given the accumulated experience with intravascular devices such as stents, heart valves, and cardiac assist devices, ...
Johnson Jarrod A JA a Department of Psychological Sciences , Purdue - - 2014
The Dispositional Flow Scale-2 (DFS-2; Jackson & Eklund, 2002) may be one of the most promising measures for assessing Csikszentmihalyi's (1990) construct of "autotelic personality." Despite strong internal validity, external validity of the DFS-2 remains open. We used 2 methods to provide evidence for external validity: (1) multiple-time assessments of ...
Hassan U U William L. Everett Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 W. Green St., Urbana, IL 61801, - - 2014
Microfluidic devices based on the Coulter principle require a small aperture for cell counting. For applications using such cell counting devices, the volume of the sample also needs to be metered to determine the absolute cell count in a specific volume. Hence, integrated methods to characterize and meter the volume ...
Baikoussis Nikolaos G NG Cardiac Surgery Department, Institut Mutualiste Montsouris, Paris, 75014, France. Electronic address: - - 2014
Mini-extracorporeal circulation (MECC) constitutes a novel miniaturized cardiopulmonary bypass (CPB) circuit, heparin-coated and primed with aprotinin. Its membrane oxygenation is similar to conventional cardio-pulmonary bypass (CCPB), but it is a completely closed-volume system due to the lack of the venous reservoir which has been removed. In a mini circuit, the ...
Kim Geon-Hyeong GH Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, - - 2014
To assess the efficacy of unilateral use of a blood reinfusion device in one-stage bilateral total knee arthroplasty (TKA). We carried out a retrospective cohort study on 100 patients having one-stage bilateral TKA. In 50 of these patients (study group), a blood reinfusion device was applied on one knee and ...
Lindgren Emelie E Department of Medical Radiation Physics, Lund University, Lund University Hospital, 22185, Lund, Sweden, - - 2014
Dynamic susceptibility contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF. Twenty healthy volunteers were scanned in a test-retest ...
Khoshnevis Sepideh S Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, - - 2014
Localized cooling is widely used in treating soft tissue injuries by modulating swelling, pain, and inflammation. One of the primary outcomes of localized cooling is vasoconstriction within the underlying skin. It is thought that in some instances, cryotherapy may be causative of tissue necrosis and neuropathy via cold-induced ischaemia leading ...
Tung Chih-Kuan CK Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA. - - 2014
Successful reproduction in mammals requires sperm to swim against a fluid flow and through the long and complex female reproductive tract before reaching the egg in the oviduct. Millions of them do not make it. Despite their clinical importance, the roles played in sperm migration by the diverse biophysical and ...
Garza-García Lucía D LD Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Ave. Eugenio Garza-Sada 2501, Monterrey, N. L., México. - - 2014
We used continuous flow micro-devices as bioreactors for the production of a glycosylated pharmaceutical product (a monoclonal antibody). We cultured CHO cells on the surface of PMMA/PDMS micro-channels that had been textured by micromachining and coated with fibronectin. Three different micro-channel geometries (a wavy channel, a zigzag channel, and a ...
Behara Srinivas R B SR Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United - - 2014
New active dry powder inhaler systems were developed and tested to efficiently aerosolize a carrier-free formulation. To assess inhaler performance, a challenging case study of aerosol lung delivery during high-flow nasal cannula (HFNC) therapy was selected. The active delivery system consisted of a ventilation bag for actuating the device, the ...
Roff M M Health and Safety Laboratory, Buxton, Derbyshire, UK. Electronic address: - - 2014
Exposure to blood and body fluids is an occupational hazard in healthcare. Although the potential for blood-borne virus transmission through needlestick injury has been widely studied, the risk of this occurring through spatter contamination from safety-needle syringes is not well understood. This report examines this risk from three commonly used ...
Tria Scherrine A SA Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, - - 2014
Ion flow across polarized epithelia is a tightly regulated process. Measurement of the transepithelial resistance is a highly relevant parameter for assessing the function or health of the tissue. Dynamic, electrical measurements of transepithelial ion flow are preferred as they provide the most accurate snapshot of effects of external stimuli. ...
Bowen Raffick A R RA Department of Pathology, Stanford University, Stanford, CA 94305, - - 2014
Improper design or use of blood collection devices can adversely affect the accuracy of laboratory test results. Vascular access devices, such as catheters and needles, exert shear forces during blood flow, which creates a predisposition to cell lysis. Components from blood collection tubes, such as stoppers, lubricants, surfactants, and separator ...
Vagdatli Eleni E 1Hematology Laboratory, Department of Medical Laboratory Studies, Technological Educational Institution of Thessaloniki, Thessaloniki, - - 2014
The aim of this study is to investigate whether the electromagnetic fields associated with mobile phones and/or laptops interfere with blood cell counts of hematology analyzers. Random blood samples were analyzed on an Aperture Impedance hematology analyzer. The analysis was performed in four ways: (A) without the presence of any ...
Cid J J Department of Hemotherapy and Hemostasis, Hospital Clínic, IDIBAPS, Barcelona, - - 2014
Automation of blood component preparation (BCP) from whole blood (WB) collections is increasingly being widespread implemented. This review summarizes the quality of blood components obtained with new automated devices. We reviewed available literature on the quality of blood components obtained with new automated devices developed in the 2000s. Blood components ...
Kumar Neeraj N Nanoscience Laboratory, Department of Physics, University of Trento, 38123 Povo, Italy. - - 2014
Porous materials are ideal hosts to fabricate high sensitivity devices. Their large specific area and the possibility to modify the type and the strength of the matrix-analyte interactions allow the realization of sensors with finely tailored characteristics. In this article, we investigate how mass transport across the nanoporous structure influences ...
So-Osman Cynthia C From the Department Center of Clinical Transfusion Research, Sanquin Blood Supply, Leiden, The Netherlands (C.S.-O., J.A.V.H., and A.B.); Department of Orthopedic Surgery, Leiden University Medical Center, RC Leiden, The Netherlands (R.G.H.H.N.); Department of Anaesthesiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands (A.W.M.M.K.-v.G.); Department of Anaesthesiology, Slotervaart Hospital, Amsterdam, The Netherlands (E.K.); Department of Orthopedic Surgery, Slotervaart Hospital, Amsterdam, The Netherlands, and VU University Medical Center, Amsterdam, The Netherlands (R.G.P.); Department of Orthopedic Surgery, Groene Hart Hospital, Gouda, The Netherlands (R.O.); Department of Medical Statistics and BioInformatics, Leiden University Medical Center, Leiden, The Netherlands (T.M.J.-W. and R.B.); Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands (W.B.v.d.H.); and Department of Immunohaematology and Blood Transfusion Service, Leiden University Medical Center, Leiden, The Netherlands - - 2014
Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. In a factorial design, adult elective hip- and knee-surgery patients with hemoglobin levels 10 to 13 g/dl (n = ...
Reif Philipp - - 2014
Abstract Background: Although fetal blood sampling for pH is well established the use of lactate has not been widely adopted. This study validated the performance and utility of a handheld point-of-care (POC) lactate device in comparison with the lactate and pH values obtained by the ABL 800 blood gas analyzer. ...
Yang Zhaochu - - 2014
This work describes a capacitive sensor for identification of microfluidic two-phase flow in lab-on-chip devices. With interdigital electrodes and thin insulation layer utilized, this sensor is capable of being integrated with the microsystems easily. Transducing principle and design considerations are presented with respect to the microfluidic gas/liquid flow patterns. Numerical ...
Elkins Mark R MR Royal Prince Alfred Hospital, Sydney, - - 2014
Drug inhalation via a dry-powder inhaler (DPI) is a convenient, time efficient alternative to nebulizers in the treatment of cystic fibrosis (CF). Efficient drug administration via DPIs depends on the device resistance and adequate (≥ 45L/min) inspiratory flows and volumes generated by individuals. Dry-powder mannitol is delivered using a RS01 ...
Elkins Mark R MR Royal Prince Alfred Hospital, Sydney, - - 2014
Drug inhalation via a dry-powder inhaler (DPI) is a convenient, time efficient alternative to nebulizers in the treatment of cystic fibrosis (CF) or non-CF bronchiectasis. Efficient drug administration via DPIs depends on the device resistance and adequate (≥45L/min) inspiratory flows and volumes generated by individuals. Drypowder mannitol is delivered using ...
Zanaty Mario M Department of Neurosurgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University , Philadelphia , PA, - - 2014
Endovascular therapy is now the treatment of choice for intracranial aneurysms (IAs) for its efficacy and safety profile. The use of flow diversion (FD) has recently expanded to cover many types of IAs in various locations. Some institutions even attempt FD as first line treatment for unruptured IAs. The most ...
Kulkarni Amol A AA Chem. Eng. & Proc. Dev. Division, CSIR-National Chemical Laboratory, Pune - 411 008, India, phone: - - 2014
This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic ...
Tran Tuan M TM Joint UCSF/UCB Bioengineering Graduate Group, University of California, San Francisco 1700, 4th Street, Byers Hall 303C, San Francisco, California 94158, - - 2014
We have developed a coaxial flow focusing geometry that can be fabricated using soft lithography in poly(dimethylsiloxane) (PDMS). Like coaxial flow focusing in glass capillary microfluidics, our geometry can form double emulsions in channels with uniform wettability and of a size much smaller than the channel dimensions. However, In contrast ...
Lucas Thabata Coaglio TC Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, - - 2013
Although catheters with side holes allow high flow rate during hemodialysis, they also induce flow disturbances and create a critical hemodynamic environment that can favor fibrin deposition and thrombus formation. This study compared the blood flow and analyzed the influence of shear stress and shear rate in fibrin deposition and ...
Mitropoulos Alexander N AN Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, - - 2013
A custom-made co-flow capillary device is used to synthesize monodisperse silk fibroin micro- and submicron-spheres with diameters tunable over a wide range of sizes. A model drug release is examined and control of degradation kinetics was obtained by changing sphere diameter.
Gong Xiuqing - - 2013
With the view of enhancing the functionality of label-free single molecule nanopore based detection, we have designed and developed a highly robust, mechanically stable integrated nanopipette-microfluidic device which combines the recognized advantages of microfluidic systems and the unique properties /advantages of nanopipettes. Unlike more typical planar solid-state nanopores, which have ...
Behara Srinivas R B - - 2013
High-efficiency dry powder inhalers (DPIs) were developed and tested for use with carrier-free formulations across a range of different inhalation flow rates. Performance of a previously reported DPI was compared with two new designs in terms of emitted dose (ED) and aerosolization characteristics using in vitro experiments. The two new ...
Anupindi Kameswararao - - 2013
Computational fluid dynamics (CFD) simulations are becoming a reliable tool to understand hemodynamics, disease progression in pathological blood vessels and to predict medical device performance. Immersed boundary method (IBM) emerged as an attractive methodology because of its ability to efficiently handle complex moving and rotating geometries on structured grids. However, ...
Choi E S - - 2013
We investigated changes in concentrations of interleukin-1β, interleukin-6, tumour necrosis factor-α and bradykinin in blood during passage through a cell salvage device and a leucocyte depletion filter, with or without application of subatmospheric pressure across the filter. Blood samples from 19 healthy women undergoing scheduled caesarean section showed concentrations of ...
de Almeida J P P G L - - 2013
An educational device was created to develop a hands-on activity to illustrate how atherosclerosis can dramatically reduce blood flow in human vessels. The device was conceived, designed, and built at the University of Coimbra, in response to a request from the Exploratório Infante D. Henrique Science Centre Museum, where it ...
Yoon Chiyul - - 2013
The continuous autotransfusion system has been widely used in surgical operations. It is known that if oil is added to blood, and this mixture is then processed by an autotransfusion device, the added oil is removed and reinfusion of fat is prevented by the device. However, there is no detailed ...
Robinet Sylvain S Service d'hématologie biologique, Assistance publique-Hôpitaux de Paris, Hôpital européen Georges Pompidou, Paris, - - 2013
Preliminary evaluation of quantitative clinical laboratory measurements is a prerequisite for the accreditation of clinical laboratories, according to the French Committee of Accreditation guidelines following the European reference Standard EN ISO 15189. Numerous papers have been published regarding biochemistry and immunology. However, data are lacking for automated complete blood count ...
Schramel Johannes P - - 2013
We describe and test a novel device for large animal anaesthesia monitoring that uses standard human medicine spirometry sensors. In-vitro study. The device consists of two adapters that enable the flow to be split evenly into four tubes in parallel, each tube containing a D-lite sensor. The performance of this ...
Jezierski Stefan - - 2013
A current challenge in continuous flow chemistry using microfluidic devices is the combination with a micropreparative separation technique for online product clean-up and analysis. Herein we describe an approach for seamless on-chip integration of continuous flow reactors with a downstream separation functionality based on free-flow electrophoresis. A prototype device was ...
Ansari Aiysha - - 2013
Objective. To determine whether retractable intravenous devices produced blood splatter and whether blood splatter frequency differed between visual and microscopy detection methods. Methods. In this laboratory-based experiment, 105 venipunctures were performed in a simulated brachial vein containing mock venous blood. The retraction mechanism was activated in a testing chamber with precut fabric ...
Wollowitz Andrew - - 2013
Hemolysis of blood samples drawn in the emergency department (ED) is a common problem that can interfere with timely diagnosis and appropriate treatment. The objective of this study was to identify the smallest number of remediable factors that independently increases the risk of hemolysis to design an effective strategy to ...
Pfützner A - - 2013
Abstract Since 2003, blood glucose meters for patient self testing are approved in Europe based on the accuracy performance criteria as defined by the ISO15197 guideline. A new draft ISO guideline is currently under regulatory review, which suggests more strict accuracy acceptance criteria, and which may not be entirely fulfilled ...
Iwersen M - - 2013
The objective of this study was to determine the suitability of 2 electronic hand-held devices [FreeStyle Precision (FSP), Abbott GmbH & Co. KG, Wiesbaden, Germany and GlucoMen LX Plus (GLX), A. Menarini GmbH, Vienna, Austria] for measuring β-hydroxybutyrate (BHBA) in dairy cows. Three experiments were conducted to evaluate (1) the ...
Mesotten Dieter - - 2013
Dr Blixt and colleagues show in an elegant pilot study that the continuous measurement of glucose in venous blood by microdialysis in a central venous catheter is feasible in critically ill patients. The performance of this type of continuous glucose monitoring device equals the performance of the commonly used handheld ...
Bukowska Danuta M - - 2013
Although Doppler optical coherence tomography techniques have enabled the imaging of blood flow in mid-sized vessels in biological tissues, the generation of velocity maps of capillary networks remains a challenge. To better understand the origin and information content of the Doppler signal from small vessels and limitations of such measurements, ...
Qin Jianbing - - 2013
Cell-free RNA (cfRNA) naturally occurs in blood and has clinical significance. Accurate quantification of these extracellular RNAs in whole blood is hindered by the simultaneous unintended release of cellular RNA and degradation of cfRNA after blood draw. An appropriate blood collection device is needed to stabilize cfRNA during blood processing, ...
Posner Jonathan D - - 2013
In our original paper "Partition Coefficient Measurements in Picoliter Drops Using a Segmented Flow Microfluidic Device" we report octanol-water partition measurements on thousands of drops in a segmented flow microfluidic device. We showed that partitioning of fluorescein reaches a steady state value in a few seconds and compares well with ...
Thompson Ian M IM - - 2013
Radical cystectomy (RC) is associated with significant blood loss and transfusion requirement. We performed a prospective, randomized trial to compare blood loss, operative time, and cost using 2 different and commonly employed approaches to tissue ligation and division during RC: mechanical (stapler device) and electrosurgical (heat-sealing device). Eighty patients undergoing ...
Acocello Shellie - - 2013
Current assessment of sport-related concussion involves a multifaceted approach including neurocognitive testing, symptom report, and balance assessment. Lacking from this paradigm is a truly objective measure of the physiological changes associated with concussion. A device called the Brain Acoustic Monitor (BAM) has been developed to detect cerebral blood flow changes ...
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