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Yan Yuanjun Y Singapore Institute for Neurotechnology, 28 Medical Dr. #05-COR, Singapore - - 2014
We present a high-throughput continuous-flow C. elegans sorting device that works based on integrated optical fiber detection and laminar flow switching. Two types of genetically engineered nematodes are allowed to flow into the device and their genotypes are detected based on their fluorescence, without the need for immobilization, by integrated ...
Fujii Kozo K Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Yoshinodai, Chuo-ku, Sagamihara 252-5210, Japan - - 2014
The dielectric barrier discharge (DBD) plasma actuator that controls flow separation is one of the promising technologies to realize energy savings and noise reduction of fluid dynamic systems. However, the mechanism for controlling flow separation is not clearly defined, and this lack of knowledge prevents practical use of this technology. ...
Rosypal Alexa C AC Department of Natural Sciences and Mathematics, College of Science, Technology, Engineering and Mathematics, Johnson C. Smith University, Charlotte, NC 28216, USA. Electronic address: - - 2014
Collection of blood samples from veterinary and wildlife patients is often challenging because the samples have to be collected on farm or in the wild under various environmental conditions. This poses many technical problems associated with venipuncture materials, their safe use and disposal, transportation and processing of collected samples. Dried ...
Knuuttila Anna - - 2014
Aleutian mink disease virus (AMDV) is the cause of a chronic immune complex disease, Aleutian disease (AD), which is common in mink-producing countries. In 2005, implementation of an AMDV eradication programme in Finland created a need for an automated high-throughput assay. The aim of this study was to validate an ...
Murlidhar Vasudha V Department of Chemical Engineering, University of Michigan, 3074 H.H. Dow, 2300 Hayward St. Ann Arbor, MI, 48109, - - 2014
Circulating tumor cells (CTCs) are believed to play an important role in metastasis, a process responsible for the majority of cancer-related deaths. But their rarity in the bloodstream makes microfluidic isolation complex and time-consuming. Additionally the low processing speeds can be a hindrance to obtaining higher yields of CTCs, limiting ...
Kashiyama Noriyuki N Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Yamadaoka, 2-2, Suita City, Osaka, 565-0087, Japan, - - 2014
In contrast to a pulsatile-flow left ventricular assist device (LVAD), an LVAD off test for evaluation of cardiac recovery with a continuous-flow device is difficult because of intra-circuit backflow from the outflow graft when a device is stopped. We report a case of reliable evaluation of cardiac recovery using balloon ...
Neyrinck Marleen M MM AZ Delta, Roeselare, - - 2014
It's important to work smoothly with your apheresis equipment when you are an apheresis nurse. Attention should be paid to your donor/patient and the product you're collecting. It gives additional value to your work when you are able to calculate the efficiency of your procedures. You must be capable to ...
Daniele Michael A MA Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, 4555 Overlook Ave. SW, DC 20375, USA. Electronic address: - - 2014
While the physics behind laminar flows has been studied for 200 years, understanding of how to use parallel flows to augment the capabilities of microfluidic systems has been a subject of study primarily over the last decade. The use of one flow to focus another within a microfluidic channel has ...
Roland L L Clinical Unit for Herd Health Management for Ruminants, University Clinic for Ruminants, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, - - 2014
The objective of this study was to evaluate the suitability of the V-Sight hematology analyzer (A. Menarini Pharma GmbH, Vienna, Austria) for bovine blood by a comparison with a reference device (Advia 2120i, Siemens AG, Erlangen, Germany). In total, 97 blood samples were obtained from 75 dairy cows. Analyzed parameters ...
Yoon Dong Hyun DH Faculty of Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku, Tokyo, Japan. - - 2014
This paper describes a microdroplet merging device that can actively control the merging of various droplets under a wide range of flow conditions, using a simple structure. The microdroplets were trapped and merged in a wide chamber divided by pillars, and their behavior was controlled by two horizontal pneumatic microactuators. ...
Seyfried Timo T Department of Anesthesiology, University Hospital Regensburg, Regensburg, - - 2014
New technical developments such as a small Latham bowl, a continuous autotransfusion system, and a dynamic disk designed for postoperative autotransfusion raise hopes for a possible application of blood salvage in young children. However, the minimal blood volume for effective processing under clinically relevant conditions has yet to be determined. ...
Yan Sheng S School of Mechanical, Materials and Mechatronic Engineering, University of Wollongong, Wollongong, NSW 2522, Australia. - - 2014
Plasma is a complex substance that contains proteins and circulating nucleic acids and viruses that can be utilised for clinical diagnostics, albeit a precise analysis depends on the plasma being totally free of cells. We proposed the use of a dielectrophoresis (DEP)-active hydrophoretic method to isolate plasma from blood in ...
Zhao Ya Y Department of Mechanical Engineering, University of Washington, WA 98195, - - 2014
The widespread use of wormlike micellar solutions is commonly found in household items such as cosmetic products, industrial fluids used in enhanced oil recovery and as drag reducing agents, and in biological applications such as drug delivery and biosensors. Despite their extensive use, there are still many details about the ...
Nawaz Ahmad Ahsan AA Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, - - 2014
Cost-effective, high-performance diagnostic instruments are vital to providing the society with accessible, affordable, and high-quality healthcare. Here we present an integrated, "microfluidic drifting" based flow cytometry chip as a potential inexpensive, fast, and reliable diagnostic tool. It is capable of analyzing human blood for cell counting and diagnosis of diseases. ...
van den Besselaar Anton M H P AM From the Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands; - - 2014
The aim of this study was to prepare control blood for an external quality assessment scheme (EQAS) for international normalized ratio (INR) point-of-care testing (POCT) in the Netherlands and to assess the performance of the participants. Control blood was prepared from dialyzed pooled patient plasma and washed human erythrocytes. Samples ...
De Luca Roberta R Neonatology and Paediatric Intensive Care Unit, Paediatrics Department, Faculty of Medicine of Geneva & University Hospitals of Geneva, 4, Rue Gabrielle-Perret-Gentil, CH-1211 Geneva 14, - - 2014
Point of care devices (POCT) are used for coagulation evaluation in adults. Reduced blood volumes and the direct use of whole blood allow studies when venous puncture is difficult, such as in newborns. Elimination of sample transport is attractive for use in emergencies and intensive care. To prospectively compare neonatal ...
Luo Yuan Y Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, - - 2014
We report on reversible electroporation of cells in a flow-through microfluidic device, whereby the required electric field is delivered through a set of integrated microcapillaries between a centre stream of cells and side streams of liquid electrolytes. The electrolytes are applied with a sine wave voltage and cells flow by ...
Son Jun Ho JH Department of Bioengineering, Department of Electrical Engineering and Computer Sciences, Biophysics Program, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, USA. - - 2014
Hemolysis, involving the rupture of red blood cells (RBCs) and release of their contents into blood plasma, is a major issue of concern in clinical fields. Hemolysis in vitro can occur as a result of errors in clinical trials; in vivo, hemolysis can be caused by a variety of medical ...
Fiedoruk Marta M University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, - - 2014
A miniature flow-through detector useful for bimodal, photometric and fluorimetric, determination of phosphates has been developed. This optoelectronic device made of four light emitting diodes (LEDs) integrated in the form of 85µL optical cell is easily applied in flow analysis manifolds. These LEDs play the roles of light source for ...
Satish Siddarth S Gauss Surgical, Inc, Los Altos, - - 2014
Visual and gravimetric methods of estimating blood loss are severely limited by human error and the presence of large volumes of amniotic fluid, irrigation, or both. The study goal was to assess accuracy of a novel system for intraoperative monitoring of hemoglobin (Hb) loss. After institutional review board approval, 50 ...
Bennett-Guerrero Elliott E Duke Clinical Research Institute, Duke University, Durham, North - - 2014
Pretransfusion washing of red blood cells (RBCs) stored for a longer duration may have theoretical advantages but few data exist to support this practice. In many hospital settings, use of a point-of-care cell washer could conceivably be used to quickly wash allogeneic RBCs before transfusion. The purpose of this preliminary ...
Shu Bowen B MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, - - 2014
High-throughput and rapid identification of multiple foodborne bacterial pathogens is vital in global public health and food industry. To fulfill this need, we propose a segmented continuous-flow multiplex polymerase chain reaction (SCF-MPCR) on a spiral-channel microfluidic device. The device consists of a disposable polytetrafluoroethylene (PTFE) capillary microchannel coiled on three ...
Um Grace T GT Washington University School of Medicine, St. Louis, MO, - - 2014
The Cook-Swartz Doppler has long been a trusted tool for close monitoring of blood flow after microvascular reconstruction; however, device implantation requires additional operating time. Synovis Life Technologies, Inc. received FDA approval in 2010 for the Flow Coupler, which combines an end-to-end anastomotic coupler with a removable 20 MHz Doppler, ...
Aznaveh Nahid Babaei NB Département de Chimie, Université Laval, 1045 Avenue de la Médecine, Québec, QC G1V 0A6, Canada. - - 2014
We present a microfluidic device capable of patterning linear biofilm formations using a flow templating approach. We describe the design considerations and fabrication methodology of a two level flow-templating micro-bioreactor (FT-μBR), which generates a biofilm growth stream surrounded on 3 sides by a growth inhibiting confinement stream. Through a combination ...
Rochow Niels N Division of Neonatology, Department of Pediatrics, McMaster University, Hamilton, Ontario, - - 2014
A miniaturized oxygenator device that is perfused like an artificial placenta via the umbilical vessels may have significant potential to save the lives of newborns with respiratory insufficiency. Recently we presented the concept of an integrated modular lung assist device (LAD) that consists of stacked microfluidic single oxygenator units (SOUs) ...
Dormanesh Banafshe B Department of Pediatric Nephrology, AJA University of Medical Sciences, Tehran, IR - - 2014
Occurrence of hypotension during hemodialysis in nearly 20-30% of patients, shows is the necessity of continuous monitoring the patients' blood pressure during hemodialysis. Since directly and non-invasively continuous blood pressure monitoring, is not easy, finding a parameter related to blood pressure, for indirect monitoring is of great value. Related blood ...
Olorunsola Olufoladare G OG Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave., Room 381, Box 0628, San Francisco, CA 94143, - - 2014
The purpose of this study was to investigate the utility and limitations of various imaging modalities in the noninvasive assessment of a novel compact hemodialyzer under development for renal replacement therapy, with specific aim towards monitoring its functional performance. The prototype is a 4×3×6 cm aluminum cartridge housing "blood" and ...
- - 2014
This revision is intended to update the 1994 ICSH guidelines. It is based on those guidelines but is updated to include new methods, such as digital image analysis for blood cells, a flow cytometric method intended to replace the reference manual 400 cell differential, and numerous new cell indices not ...
Chen Chengpeng C Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA. - - 2014
A fluidic device constructed with a 3D-printer can be used to investigate stored blood components with subsequent high-throughput calibration and readout with a standard plate reader.
Pfenniger Alois A ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland; Engineering and Information Technology, Bern University of Applied Sciences, Biel, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, - - 2014
Replacement intervals of implantable medical devices are commonly dictated by battery life. Therefore, intracorporeal energy harvesting has the potential to reduce the number of surgical interventions by extending the life cycle of active devices. Given the accumulated experience with intravascular devices such as stents, heart valves, and cardiac assist devices, ...
Mariani Mariagabriella M Flow Cytometry Service, Laboratory of Clinical Chemistry and Microbiology, IRCCS "Ca' Granda" Foundation, Maggiore Hospital Policlinico, Milan, - - 2014
Accurate estimation of haematopoietic stem cell (HSC) counts by flow cytometry may be difficult in laboratories in which sophisticated equipment and staff with specific expertise are not available. Affordable flow cytometers that can perform basic functions may help to overcome these difficulties. In this study we compared HSC and leucocyte ...
Johnson Jarrod A JA a Department of Psychological Sciences , Purdue - - 2014
The Dispositional Flow Scale-2 (DFS-2; Jackson & Eklund, 2002) may be one of the most promising measures for assessing Csikszentmihalyi's (1990) construct of "autotelic personality." Despite strong internal validity, external validity of the DFS-2 remains open. We used 2 methods to provide evidence for external validity: (1) multiple-time assessments of ...
Hassan U U William L. Everett Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 W. Green St., Urbana, IL 61801, - - 2014
Microfluidic devices based on the Coulter principle require a small aperture for cell counting. For applications using such cell counting devices, the volume of the sample also needs to be metered to determine the absolute cell count in a specific volume. Hence, integrated methods to characterize and meter the volume ...
Baikoussis Nikolaos G NG Cardiac Surgery Department, Institut Mutualiste Montsouris, Paris, 75014, France. Electronic address: - - 2014
Mini-extracorporeal circulation (MECC) constitutes a novel miniaturized cardiopulmonary bypass (CPB) circuit, heparin-coated and primed with aprotinin. Its membrane oxygenation is similar to conventional cardio-pulmonary bypass (CCPB), but it is a completely closed-volume system due to the lack of the venous reservoir which has been removed. In a mini circuit, the ...
Conway A J AJ Bioengineering Center, Charles Stark Draper Laboratory, Tampa, Florida 33612, - - 2014
Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many devices, ...
Kim Geon-Hyeong GH Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, - - 2014
To assess the efficacy of unilateral use of a blood reinfusion device in one-stage bilateral total knee arthroplasty (TKA). We carried out a retrospective cohort study on 100 patients having one-stage bilateral TKA. In 50 of these patients (study group), a blood reinfusion device was applied on one knee and ...
Lindgren Emelie E Department of Medical Radiation Physics, Lund University, Lund University Hospital, 22185, Lund, Sweden, - - 2014
Dynamic susceptibility contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF. Twenty healthy volunteers were scanned in a test-retest ...
Khoshnevis Sepideh S Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, - - 2014
Localized cooling is widely used in treating soft tissue injuries by modulating swelling, pain, and inflammation. One of the primary outcomes of localized cooling is vasoconstriction within the underlying skin. It is thought that in some instances, cryotherapy may be causative of tissue necrosis and neuropathy via cold-induced ischaemia leading ...
Tung Chih-Kuan CK Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA. - - 2014
Successful reproduction in mammals requires sperm to swim against a fluid flow and through the long and complex female reproductive tract before reaching the egg in the oviduct. Millions of them do not make it. Despite their clinical importance, the roles played in sperm migration by the diverse biophysical and ...
Garza-García Lucía D LD Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Ave. Eugenio Garza-Sada 2501, Monterrey, N. L., México. - - 2014
We used continuous flow micro-devices as bioreactors for the production of a glycosylated pharmaceutical product (a monoclonal antibody). We cultured CHO cells on the surface of PMMA/PDMS micro-channels that had been textured by micromachining and coated with fibronectin. Three different micro-channel geometries (a wavy channel, a zigzag channel, and a ...
Behara Srinivas R B SR Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA, United States; Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, United - - 2014
New active dry powder inhaler systems were developed and tested to efficiently aerosolize a carrier-free formulation. To assess inhaler performance, a challenging case study of aerosol lung delivery during high-flow nasal cannula (HFNC) therapy was selected. The active delivery system consisted of a ventilation bag for actuating the device, the ...
Roff M M Health and Safety Laboratory, Buxton, Derbyshire, UK. Electronic address: - - 2014
Exposure to blood and body fluids is an occupational hazard in healthcare. Although the potential for blood-borne virus transmission through needlestick injury has been widely studied, the risk of this occurring through spatter contamination from safety-needle syringes is not well understood. This report examines this risk from three commonly used ...
Tria Scherrine A SA Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, - - 2014
Ion flow across polarized epithelia is a tightly regulated process. Measurement of the transepithelial resistance is a highly relevant parameter for assessing the function or health of the tissue. Dynamic, electrical measurements of transepithelial ion flow are preferred as they provide the most accurate snapshot of effects of external stimuli. ...
Bowen Raffick A R RA Department of Pathology, Stanford University, Stanford, CA 94305, - - 2014
Improper design or use of blood collection devices can adversely affect the accuracy of laboratory test results. Vascular access devices, such as catheters and needles, exert shear forces during blood flow, which creates a predisposition to cell lysis. Components from blood collection tubes, such as stoppers, lubricants, surfactants, and separator ...
Vagdatli Eleni E 1Hematology Laboratory, Department of Medical Laboratory Studies, Technological Educational Institution of Thessaloniki, Thessaloniki, - - 2014
The aim of this study is to investigate whether the electromagnetic fields associated with mobile phones and/or laptops interfere with blood cell counts of hematology analyzers. Random blood samples were analyzed on an Aperture Impedance hematology analyzer. The analysis was performed in four ways: (A) without the presence of any ...
Cid J J Department of Hemotherapy and Hemostasis, Hospital Clínic, IDIBAPS, Barcelona, - - 2014
Automation of blood component preparation (BCP) from whole blood (WB) collections is increasingly being widespread implemented. This review summarizes the quality of blood components obtained with new automated devices. We reviewed available literature on the quality of blood components obtained with new automated devices developed in the 2000s. Blood components ...
Kumar Neeraj N Nanoscience Laboratory, Department of Physics, University of Trento, 38123 Povo, Italy. - - 2014
Porous materials are ideal hosts to fabricate high sensitivity devices. Their large specific area and the possibility to modify the type and the strength of the matrix-analyte interactions allow the realization of sensors with finely tailored characteristics. In this article, we investigate how mass transport across the nanoporous structure influences ...
So-Osman Cynthia C From the Department Center of Clinical Transfusion Research, Sanquin Blood Supply, Leiden, The Netherlands (C.S.-O., J.A.V.H., and A.B.); Department of Orthopedic Surgery, Leiden University Medical Center, RC Leiden, The Netherlands (R.G.H.H.N.); Department of Anaesthesiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands (A.W.M.M.K.-v.G.); Department of Anaesthesiology, Slotervaart Hospital, Amsterdam, The Netherlands (E.K.); Department of Orthopedic Surgery, Slotervaart Hospital, Amsterdam, The Netherlands, and VU University Medical Center, Amsterdam, The Netherlands (R.G.P.); Department of Orthopedic Surgery, Groene Hart Hospital, Gouda, The Netherlands (R.O.); Department of Medical Statistics and BioInformatics, Leiden University Medical Center, Leiden, The Netherlands (T.M.J.-W. and R.B.); Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands (W.B.v.d.H.); and Department of Immunohaematology and Blood Transfusion Service, Leiden University Medical Center, Leiden, The Netherlands - - 2014
Patient blood management combines the use of several transfusion alternatives. Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold. In a factorial design, adult elective hip- and knee-surgery patients with hemoglobin levels 10 to 13 g/dl (n = ...
Reif Philipp - - 2014
Abstract Background: Although fetal blood sampling for pH is well established the use of lactate has not been widely adopted. This study validated the performance and utility of a handheld point-of-care (POC) lactate device in comparison with the lactate and pH values obtained by the ABL 800 blood gas analyzer. ...
Yang Zhaochu - - 2014
This work describes a capacitive sensor for identification of microfluidic two-phase flow in lab-on-chip devices. With interdigital electrodes and thin insulation layer utilized, this sensor is capable of being integrated with the microsystems easily. Transducing principle and design considerations are presented with respect to the microfluidic gas/liquid flow patterns. Numerical ...
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