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Ingham Richard J RJ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, - - 2014
Here we describe the use of a new open-source software package and a Raspberry Pi(®) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater(®), used in the treatment of tuberculosis - and its ...
De Vis J B JB Department of Radiology, University Medical Center Utrecht, Utrecht, The - - 2014
The longitudinal relaxation time of blood (T 1b) is influenced by haematocrit (Hct) which is known to vary in neonates. The purpose of this study was threefold: to obtain T 1b values in neonates, to investigate how the T 1b influences quantitative arterial spin labelling (ASL), and to evaluate if ...
Zanaty Mario M Department of Neurosurgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University , Philadelphia , PA, - - 2014
Endovascular therapy is now the treatment of choice for intracranial aneurysms (IAs) for its efficacy and safety profile. The use of flow diversion (FD) has recently expanded to cover many types of IAs in various locations. Some institutions even attempt FD as first line treatment for unruptured IAs. The most ...
Funk Richard H W RH Institute for Anatomy, Medical Faculty, Dresden University of Technology, Fiedlerstraße 42, 01307 Dresden, - - 2014
A novel hand-held low-frequency magnetic stimulator (MagCell-SR) was tested for its ability to stimulate microcirculation in fingers of healthy volunteers. Blood flow during and after 5 minutes exposure was quantified using Laser Doppler Perfusion Imaging Technique. The device was positioned between the wrist and the dorsal part of the backhand. ...
Lucas Thabata Coaglio TC Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Belo Horizonte, - - 2013
Although catheters with side holes allow high flow rate during hemodialysis, they also induce flow disturbances and create a critical hemodynamic environment that can favor fibrin deposition and thrombus formation. This study compared the blood flow and analyzed the influence of shear stress and shear rate in fibrin deposition and ...
Mitropoulos Alexander N AN Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, - - 2013
A custom-made co-flow capillary device is used to synthesize monodisperse silk fibroin micro- and submicron-spheres with diameters tunable over a wide range of sizes. A model drug release is examined and control of degradation kinetics was obtained by changing sphere diameter.
Gong Xiuqing - - 2013
With the view of enhancing the functionality of label-free single molecule nanopore based detection, we have designed and developed a highly robust, mechanically stable integrated nanopipette-microfluidic device which combines the recognized advantages of microfluidic systems and the unique properties /advantages of nanopipettes. Unlike more typical planar solid-state nanopores, which have ...
Behara Srinivas R B - - 2013
High-efficiency dry powder inhalers (DPIs) were developed and tested for use with carrier-free formulations across a range of different inhalation flow rates. Performance of a previously reported DPI was compared with two new designs in terms of emitted dose (ED) and aerosolization characteristics using in vitro experiments. The two new ...
Anupindi Kameswararao - - 2013
Computational fluid dynamics (CFD) simulations are becoming a reliable tool to understand hemodynamics, disease progression in pathological blood vessels and to predict medical device performance. Immersed boundary method (IBM) emerged as an attractive methodology because of its ability to efficiently handle complex moving and rotating geometries on structured grids. However, ...
Choi E S - - 2013
We investigated changes in concentrations of interleukin-1β, interleukin-6, tumour necrosis factor-α and bradykinin in blood during passage through a cell salvage device and a leucocyte depletion filter, with or without application of subatmospheric pressure across the filter. Blood samples from 19 healthy women undergoing scheduled caesarean section showed concentrations of ...
de Almeida J P P G L - - 2013
An educational device was created to develop a hands-on activity to illustrate how atherosclerosis can dramatically reduce blood flow in human vessels. The device was conceived, designed, and built at the University of Coimbra, in response to a request from the Exploratório Infante D. Henrique Science Centre Museum, where it ...
Yoon Chiyul - - 2013
The continuous autotransfusion system has been widely used in surgical operations. It is known that if oil is added to blood, and this mixture is then processed by an autotransfusion device, the added oil is removed and reinfusion of fat is prevented by the device. However, there is no detailed ...
Robinet Sylvain S Service d'hématologie biologique, Assistance publique-Hôpitaux de Paris, Hôpital européen Georges Pompidou, Paris, - - 2013
Preliminary evaluation of quantitative clinical laboratory measurements is a prerequisite for the accreditation of clinical laboratories, according to the French Committee of Accreditation guidelines following the European reference Standard EN ISO 15189. Numerous papers have been published regarding biochemistry and immunology. However, data are lacking for automated complete blood count ...
Schramel Johannes P - - 2013
We describe and test a novel device for large animal anaesthesia monitoring that uses standard human medicine spirometry sensors. In-vitro study. The device consists of two adapters that enable the flow to be split evenly into four tubes in parallel, each tube containing a D-lite sensor. The performance of this ...
Jezierski Stefan - - 2013
A current challenge in continuous flow chemistry using microfluidic devices is the combination with a micropreparative separation technique for online product clean-up and analysis. Herein we describe an approach for seamless on-chip integration of continuous flow reactors with a downstream separation functionality based on free-flow electrophoresis. A prototype device was ...
Ansari Aiysha - - 2013
Objective. To determine whether retractable intravenous devices produced blood splatter and whether blood splatter frequency differed between visual and microscopy detection methods. Methods. In this laboratory-based experiment, 105 venipunctures were performed in a simulated brachial vein containing mock venous blood. The retraction mechanism was activated in a testing chamber with precut fabric ...
Wollowitz Andrew - - 2013
Hemolysis of blood samples drawn in the emergency department (ED) is a common problem that can interfere with timely diagnosis and appropriate treatment. The objective of this study was to identify the smallest number of remediable factors that independently increases the risk of hemolysis to design an effective strategy to ...
Pfützner A - - 2013
Abstract Since 2003, blood glucose meters for patient self testing are approved in Europe based on the accuracy performance criteria as defined by the ISO15197 guideline. A new draft ISO guideline is currently under regulatory review, which suggests more strict accuracy acceptance criteria, and which may not be entirely fulfilled ...
Iwersen M - - 2013
The objective of this study was to determine the suitability of 2 electronic hand-held devices [FreeStyle Precision (FSP), Abbott GmbH & Co. KG, Wiesbaden, Germany and GlucoMen LX Plus (GLX), A. Menarini GmbH, Vienna, Austria] for measuring β-hydroxybutyrate (BHBA) in dairy cows. Three experiments were conducted to evaluate (1) the ...
Mesotten Dieter - - 2013
Dr Blixt and colleagues show in an elegant pilot study that the continuous measurement of glucose in venous blood by microdialysis in a central venous catheter is feasible in critically ill patients. The performance of this type of continuous glucose monitoring device equals the performance of the commonly used handheld ...
Bukowska Danuta M - - 2013
Although Doppler optical coherence tomography techniques have enabled the imaging of blood flow in mid-sized vessels in biological tissues, the generation of velocity maps of capillary networks remains a challenge. To better understand the origin and information content of the Doppler signal from small vessels and limitations of such measurements, ...
Hoang Anh N AN The BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Boston, - - 2013
Neutrophil chemotaxis is critical for defense against infections and its alterations could lead to chronic inflammation and tissue injury. The central role that transient alterations of neutrophil chemotaxis could have on patient outcomes calls for its quantification in the clinic. However, current methods for measuring neutrophil chemotaxis require large volumes ...
Jongman Seo - - 2013
"Vibrotactile flow" refers to a continuously moving sensation of vibrotactile stimulation applied by a few actuators directly onto the skin or through a rigid medium. Research demonstrated the effectiveness of vibrotactile flow for conveying intuitive directional information on a mobile device. In this paper, we extend previous research by investigating ...
Qin Jianbing - - 2013
Cell-free RNA (cfRNA) naturally occurs in blood and has clinical significance. Accurate quantification of these extracellular RNAs in whole blood is hindered by the simultaneous unintended release of cellular RNA and degradation of cfRNA after blood draw. An appropriate blood collection device is needed to stabilize cfRNA during blood processing, ...
Posner Jonathan D - - 2013
In our original paper "Partition Coefficient Measurements in Picoliter Drops Using a Segmented Flow Microfluidic Device" we report octanol-water partition measurements on thousands of drops in a segmented flow microfluidic device. We showed that partitioning of fluorescein reaches a steady state value in a few seconds and compares well with ...
Thompson Ian M IM - - 2013
Radical cystectomy (RC) is associated with significant blood loss and transfusion requirement. We performed a prospective, randomized trial to compare blood loss, operative time, and cost using 2 different and commonly employed approaches to tissue ligation and division during RC: mechanical (stapler device) and electrosurgical (heat-sealing device). Eighty patients undergoing ...
Acocello Shellie - - 2013
Current assessment of sport-related concussion involves a multifaceted approach including neurocognitive testing, symptom report, and balance assessment. Lacking from this paradigm is a truly objective measure of the physiological changes associated with concussion. A device called the Brain Acoustic Monitor (BAM) has been developed to detect cerebral blood flow changes ...
Gamella M M Dpto. Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, E-28040 Madrid, Spain. Electronic address: - - 2014
A non-invasive, passive and simple to use skin surface based sensing device for determining the blood's ethanol content (BAC) by monitoring transdermal alcohol concentration (TAC) is designed and developed. The proposed prototype is based on bienzyme amperometric composite biosensors that are sensitive to the variation of ethanol concentration. The prototype ...
He Jie - - 2013
Hydrodynamic flow in a microfluidic (MF) device offers a high-throughput platform for the continuous and controllable self-assembly of amphiphiles. However, the role of hydrodynamics on the assembly of colloidal amphiphiles (CAMs) is still not well understood. This article reports a systematic study of the assembly of CAMs, which consist of ...
Badr Bouchra - - 2013
Regularly monitoring blood flow through a vascular access (Qa) can predict a dysfunction and dramatically reduce the number of thromboses. The aim of our study was to compare two integrated access flow devices, thermodilution (Qa-BTM: BTM®, Fresenius Medical Care, Bad Homburg, Germany) and ionic dialysance (Qa-ID: OCM®, Fresenius Medical Care, ...
Basey-Fisher Toby H - - 2013
The non-destructive ex vivo determination of haemoglobin (Hgb) concentration offers the capability to conduct multiple red blood cell haematological measurements on a single sample, an advantage that current optical techniques are unable to offer. Here, a microwave method and device for the accurate and non-destructive determination of Hgb concentration in ...
Davidson Edward H - - 2013
The mechanotransduction mechanisms linking distraction device activation to new bone formation remain unknown. We hypothesize that the tension stress of activation during distraction osteogenesis is transmitted through lacunocanalicular fluid flow to initiate the osteogenic signaling cascade. Adult Sprague-Dawley rats (N = 24) were subjected to mandibular osteotomy and application of ...
Derman Peter B - - 2013
Blood conservation with saline-coupled bipolar sealing devices in primary total knee arthroplasty (TKA) has had mixed results. Moreover, investigators have not studied these devices in infected TKA cases in which conventional methods of blood management cannot be used. We conducted a single-surgeon, case-control study to evaluate how the choice of ...
Liang Jinyang - - 2013
A cross-correlation-based method is proposed to quantitatively measure transverse flow velocity using optical resolution photoacoustic (PA) microscopy enhanced with a digital micromirror device (DMD). The DMD is used to alternately deliver two spatially separated laser beams to the target. Through cross-correlation between the slow-time PA profiles measured from the two ...
Mut Fernando - - 2013
Quantifying the hemodynamic environment within aneurysms and its change after deployment of flow diverting devices is important to assess the device efficacy and understand their long-term effects. The purpose of this study was to estimate deviations in the quantification of the relative change of hemodynamic variables during flow diversion treatment ...
Boeker Peter - - 2013
The Deans'switch is an effluent switching device based on control flows of carrier gas instead of mechanical valves in the analytical flow path. This technique promises high inertness and a wear-free operation. Recently new monolithic microfluidic devices have become available. In these devices the whole flow system is integrated into ...
Korczyk Piotr M - - 2013
We present microfluidic modules (traps) that allow us to lock, shift, dose and merge micro-aliquots of liquid precisely. The precision is hard-wired into the geometry of the device: small values of the capillary number guarantee reproducibility of operation over a range of rates of flow that need not be controlled ...
Stemple C Christopher - - 2013
A novel smartphone-based detection device was created to detect infectious pathogens directly from diluted (10%) human whole blood. The model pathogen was histidine-rich protein 2 (HRP-2), an antigen specific to Plasmodium falciparum (malaria). Anti-HRP-2-conjugated submicrobeads were mixed with HRP-2-infused 10% blood in a lab-on-a-chip device. The white LED flash and ...
Nollet Kenneth E - - 2013
Twenty-first century demand for radio spectrum continues to increase with the explosive growth of wireless devices, but authorities reserve slices of the spectrum for licensed Amateur Radio operators, recognizing their value to the public, particularly with respect to providing emergency communications. Blood banking and transfusion medicine are among the specialties ...
Saunders Ashley B - - 2013
A left-to-right shunting muscular ventricular septal defect (VSD) was diagnosed in a 4-month-old, female, 1.8 kg Bichon Frise - poodle mix dog. Echocardiographic evidence of cardiac remodeling, calculated pulmonary blood flow (Qp) to systemic blood flow (Qs) ratio of 2.8, and radiographic evidence of pulmonary edema supported the diagnosis of a ...
Foinard A - - 2013
Stopping and restarting carrier fluid flow and performing simultaneous drug infusions can lead to hazardous disturbances in drug delivery. The present study was designed to assess in vitro whether using a multi-lumen infusion access device could prevent noradrenaline disturbances. In vitro laboratory work. Two infusion devices were studied: a standard ...
Warwick D - - 2013
Aim: Different mechanical devices for thromboprophylaxis have different flow characteristics. A new device (Vadoplex) has been developed to provide a short impulse around the calf, a concept derived from the efficacy of foot impulse technology. New devices should be compared with existing devices to establish whether it has a comparable ...
Yang Chin-Lung - - 2013
Point-of-care diagnostics (POCD) for blood coagulation benefit patients on-site, but available POCD devices are too expensive to be affordable in many countries. Optically based methodologies are cheap and reliable, and have been exploited in bench-top coagulometers to monitor coagulation with plasma, but not whole blood, which contains cellular components that ...
Yasmin Lyzu - - 2013
A vortex fluidic device (VFD) involving a rapidly rotating tube open at one end forms dynamic thin films at high rotational speed for finite sub-millilitre volumes of liquid, with shear within the films depending on the speed and orientation of the tube. Continuous flow operation of the VFD where jet ...
Yakubu Sani Ibn - - 2013
An interaction between device resistance and inhalation flow provides the 'energy' to de-aggregate the metered dose of a dry powder inhaler (DPIs). Hence all dry powder inhalers demonstrate flow dependent dose emission but information on this at low flows is not available. We have adapted the compendial method for the ...
Nielsen Vance G - - 2013
Replacement of key components of the circulatory system with artificial devices has become the mainstay of therapy for conditions such as end-stage valvular disease or congestive heart failure. Unfortunately, device thrombosis and thromboembolic morbidity persist despite optimized anticoagulation. This work reviews the commonly known causes of device-associated thrombophilia, introduces recent ...
Lima-Oliveira Gabriel - - 2013
In vitro diagnostic tests play a key role in patients' management (e.g., guiding red blood cell transfusions). The aim of this study was to evaluate the impact of an innovative device (Buzzy(®)) which is claimed to be able to relieve venipuncture pain by means of cold and vibration. This device ...
Ambrisko T D - - 2013
A spirometry device equipped with mainstream CO2 /flow sensor is not available for large animal anaesthesia. To measure the resistance of a new large animal spirometry device and assess its agreement with reference methods for volume measurements. In vitro experiment and cross-over study using anaesthetised horses. A flow partitioning device ...
Nam Jeonghun - - 2013
Malaria is a serious disease that threatens the public health, especially in developing countries. Various methods have been developed to separate malaria-infected RBCs (i-RBCs) from blood samples for clinical diagnosis and biological and epidemiological researches. In this study, we propose a simple and label-free method for separating not only late-stage ...
Wiegmann Bettina - - 2013
Combined acute lung injury (ALI) and kidney injury (AKI) is a common problem in critically ill patients. By combining pulmonary (gas exchange) and renal (hemofiltration) support in one extracorporeal device with low-flow resistance, we seek to provide less artificial surfaces maintaining sufficient organ support. Modified Interventional Lung Assist (iLA) Membrane ...
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