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McDade Eric E From the Departments of Neurology (E.M., S.I., O.L., B.S.), Psychiatry (A.K., J.B., W.K.), and Radiology (J.J., D.M., J.P., C.M., W.K.), School of Medicine, and Department of Psychology (L.K.S., D.C.-H.K., P.J.G.), School of Arts and Sciences, University of Pittsburgh, PA; and Medical College of Georgia (A.K.), Augusta. - - 2014
To evaluate alterations in cerebral blood flow (CBF) using arterial spin-labeled MRI in autosomal dominant Alzheimer disease (ADAD) mutation carriers (MCs) in relation to cerebral amyloid and compared with age-matched healthy controls.BACKGROUND: Recent work has identified alterations in CBF in elderly subjects with mild cognitive impairment and Alzheimer dementia using ...
Neidlin Michael M Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany, - - 2014
Cardiopulmonary bypass is a well-established technique during open heart surgeries. However, neurological complications due to insufficient cerebral oxygen supply occur and the severe consequences must not be neglected. Recent computational fluid dynamics (CFD) studies showed that during axillary cannulation the cerebral perfusion is strongly affected by the distance between the ...
Greisen Gorm G Department of Neonatology, Rigshospitalet and University of Copenhagen, - - 2014
The term 'luxury perfusion' was coined nearly 50years ago after observation of bright-red blood in the cerebral veins of adults with various brain pathologies. The bright-red blood represents decreased oxygen extraction and hence the perfusion is 'luxurious' compared to oxygen needs. Gradual loss of cellular energy charge during the hours ...
Murayama Kazuhiro K From the *Department of Radiology and †Neurosurgery, Fujita Health University, Toyoake, Japan; ‡Division of Nuclear Medicine, Graduate School of Medicine, University of Tokyo, Japan; Software Development Group, Product Management and Marketing Department., Sales and Marketing Division, FUJIFILM RI Pharma Co., Ltd., Japan; §Clinical Application Research Center, Toshiba Medical Systems Corporation, Otawara, Japan; and ‚ą•Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University, Toyoake, - - 2014
We compared cerebral blood flow (CBF) measured using computed tomographic (CT) perfusion (CTP) and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion single-photon emission computed tomography (SPECT). We used a 320-row area detector CT and N-isopropyl-p-[(123) I]-iodoamphetamine cerebral perfusion SPECT under similar conditions in patients with chronic cerebrovascular disease. Images were automatically aligned 3-dimensionally ...
Morell Arvid A Section of Radiology, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Uppsala, Sweden, - - 2014
Perfusion assessment by monitoring the transport of a tracer bolus depends critically on conversion of signal intensity into tracer concentration. Two main assumptions are generally applied for this conversion; (1) contrast agent relaxivity is identical in blood and tissue, (2) change in signal intensity depends only on the primary relaxation ...
Papantoniou Ioannis I Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Onderwijs en Navorsing 1 (+8), Herestraat 49 - PB813, B-3000, Leuven, Belgium; Skeletal Biology and Engineering Research Center, KU Leuven, Onderwijs en Navorsing 1 (+8), Herestraat 49 - PB813, B-3000, Leuven, - - 2014
Perfusion bioreactors have shown great promise for tissue engineering applications providing a homogeneous and consistent distribution of nutrients and flow-induced shear stresses throughout tissue-engineered constructs. However, non uniform fluid-flow profiles found in the perfusion chamber entrance region have been shown to affect tissue-engineered construct quality characteristics during culture. In this ...
Iwata Sachiko S Centre for Developmental and Cognitive Neuroscience, Department of Paediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Institute for Women's Health, University College London, London, - - 2014
Small shifts in brain temperature after hypoxia-ischaemia affect cell viability. The main determinants of brain temperature are cerebral metabolism, which contributes to local heat production, and brain perfusion, which removes heat. However, few studies have addressed the effect of cerebral metabolism and perfusion on regional brain temperature in human neonates ...
K Walker Sarah S Hiram C. Polk, Jr., M.D. Department of Surgery, University of Louisville, Louisville, - - 2014
Indomethacin, a nonselective prostaglandin inhibitor used to treat patent ductus arteriosus, is associated with intestinal perforation inducing an NEC-like illness. We sought to define the contribution of prostaglandin E2 (PG E2) and its receptor EP4 to intestinal blood flow regulation in premature neonates with NEC. Newborn Sprague-Dawley rats were randomized ...
Ge Wei W Department of Oncology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, P.R. - - 2014
The aim of this study was to observe the effects of Endostar (recombinant human endostatin) and radiotherapy, singly or in combination, on blood flow in mouse tumour tissue using ultrasound imaging. The ultrasound contrast agent, SonoVue, was used for the contrast-enhanced ultrasound examinations. SonoLiver software was used to analyse dynamic ...
Fischer Michael A MA Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland, - - 2014
The aim of this study was to prospectively monitor changes in the flow-metabolic phenotype (ΔFMP) of rectal carcinoma (RC) after neoadjuvant chemoradiotherapy (CRT) and to evaluate whether ΔFMP of RC correlate with histopathological prognostic factors including response to CRT. Sixteen patients with RC (12 men, mean age 60.7 ± 12.8 years) underwent integrated ...
Præstmark Kezia Ann KA University of Copenhagen, Department of Biomedical Sciences, Copenhagen, Denmark Novo Nordisk A/S, Device R&D, Hillerød, Denmark - - 2014
Today most research on pen needle design revolves around pain perception statements through clinical trials, but these are both costly, timely, and require high sample sizes. The purpose of this study was to test if tissue damage, caused by different types of needles, can be assessed by evaluating skin blood ...
Ginther O J OJ Eutheria Foundation, Cross Plains, Wisconsin, USA; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: - - 2014
The hemodynamics of the developing CL and the future dominant follicle (DF) was studied in 22 heifers during wave 1 on Days 0 to 5 (Day 0 = ovulation). Color-Doppler ultrasonography was used to determine the resistance index (RI) at the most prominent Doppler signal in an ovarian arterial branch before entry ...
Endo Kazuhiro K Departments of *Surgery †Radiology ‡The Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, - - 2014
The goal of this study is to examine changes in pancreatic perfusion due to pneumoperitoneum using perfusion CT in vivo. Three pigs were studied. Under general anesthesia, pneumoperitoneum was induced to 16 mm Hg. Perfusion CT scans were acquired at a rate of 1 image per 2 seconds for 60 ...
Thierfelder Kolja M KM From the Department of Clinical Radiology (K.M.T., A.B.B., W.H.S., M.A., M.F.R.), Department of Neurology (C.O., A.S., L.v.B.), Institute for Stroke and Dementia Research (C.O.), and Department of Neuroradiology (H.J.), Ludwig-Maximilians-University of Munich Hospitals, Munich, - - 2014
Vertebral artery hypoplasia (VAH) is supposed to be a risk factor for posterior circulation ischemia (PCI), particularly in the territory of the posterior inferior cerebellar artery (PICA). The aim of our study was to determine whether VAH impedes perfusion in the dependent PICA territory even in the absence of manifest ...
Guo X-D XD Emergency Medical Center, General Hospital of Armed Police Forces, Beijing, China. - - 2014
Cerebral resuscitation after cardiac arrest (CA) is always an unresolved problem in medical field. The decreased cerebral perfusion or nonperfusion caused by coagulation and fibrinolytic system function disorder and cerebral microthrombosis after CA and cardiopulmonary resuscitation (CPR) is one of the important reasons. TTo investigate the effect of urokinase on ...
Mak Henry Ka-Fung HK Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong SAR, - - 2014
Background: Structural magnetic resonance imaging has been employed for evaluation of medial temporal atrophy in patients with Alzheimer's disease (AD). Arterial spin labeling (ASL) technique could detect cerebral perfusion abnormalities in AD. Objective: We hypothesized that combination of hippocampal volumetry and cerebral blood flow yield higher accuracy than either method ...
Le Heron Campbell J CJ New Zealand Brain Research Institute, Christchurch, New - - 2014
Emerging evidence suggests that Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) share neurodegenerative mechanisms. We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI). In total, 17 AD, 20 PDD, and 37 matched healthy controls completed ASL and structural MRI, ...
Chahine George G American University of Beirut, Department of Psychiatry, P.O. Box 11-0236, Riad El-Solh, 1107 2020 Beirut, - - 2014
Use of electroconvulsive therapy (ECT) is limited by cognitive disturbance. Focal electrically-administered seizure therapy (FEAST) is designed to initiate focal seizures in the prefrontal cortex. To date, no studies have documented the effects of FEAST on regional cerebral blood flow (rCBF). A 72 year old depressed man underwent three single ...
Foppa C C Division of Colon and Rectal Surgery, Health Science Center, State University of New York, T18, Suite 046B, Stony Brook, NY, 11794-8191, - - 2014
Assessing the blood supply of the bowel is a difficult task even for experienced surgeons. Laser-assisted indocyanine green (ICG) fluorescent dye angiography provides intraoperative visual assessment of blood flow to the bowel wall and surrounding tissues, allowing for modification to the surgical plan, which can reduce the risk of postoperative ...
Liang Meng-Ya MY 1Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. 2Department of Anesthesiology, Heart Center, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
This study aimed to investigate whether selective antegrade cerebral perfusion or retrograde cerebral perfusion is a better technique for brain protection in deep hypothermic circulatory arrest by obtaining metabolic evidence from microdialysis. Randomized, animal study. Assisted circulation laboratory. Eighteen piglets of either sex (9.8 ± 3.1 kg). Animals were randomly ...
Carter Howard H HH University of Western - - 2014
Episodic increases in cerebrovascular perfusion and shear stress may have beneficial impacts on endothelial function that improve brain health. We hypothesised that water immersion to the level of the right atrium in humans would increase cerebral perfusion. We continuously measured, in 9 young (mean±SD, 24.6 ± 2.0 yrs) healthy men, ...
Donati Abele - - 2014
Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion increases oxygen (O2)-delivery but rarely improves tissue O2 uptake in septic patients. Possible causes include RBC alterations due to prolonged storage or residual leukocyte-derived inflammatory mediators. The aim of this study was to compare the effects of ...
Oskarsson Eva E Örebro University, School of Health and Medical Sciences, Örebro, - - 2014
The aim of this study was to examine possible signs of impairment of the microcirculation in the lower extremities of female patients suffering from primary restless legs syndrome/Willis-Ekbom disease. This study was performed in eight female patients, mean age 48 years (range 21-65), diagnosed with primary restless legs syndrome but ...
Hales Patrick W PW Imaging and Biophysics Unit, Institute of Child Health, University College London, London, - - 2014
The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence ...
Siemonsen Susanne S Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
The aim of this study is to investigate whether different spatial perfusion-deficit patterns, which indicate differing compensatory mechanisms, can be recognized and used to predict recanalization success of intravenous fibrinolytic therapy in acute stroke patients. Twenty-seven acute stroke data sets acquired within 6 hours from symptom onset including diffusion- (DWI) and ...
Obeid Layal L 1] INSERM, U836, Grenoble-Institut des Neurosciences, Equipe 6, Grenoble Cedex 9, France [2] Université Joseph Fourier, Grenoble Cedex 9, - - 2014
Contrast-enhanced radiotherapy is an innovative treatment that combines the selective accumulation of heavy elements in tumors with stereotactic irradiations using medium energy X-rays. The radiation dose enhancement depends on the absolute amount of iodine reached in the tumor and its time course. Quantitative, postinfusion iodine biodistribution and associated brain perfusion ...
Sarubbo Silvio S Neurosurgery Unit, Department of Neurosciences, "S. Chiara" Hospital, APSS Trento, Trento, - - 2014
Little is known about hemodynamic disturbances affecting cerebral hemispheres in traumatic brain injury (TBI) after cranioplasty. We prospectively investigated six stable TBI patients who underwent cranioplasty more than 90 days after effective decompressive craniectomy. Computerized tomography perfusion (CTP) studies and evaluation of clinical outcome were performed for each patient before cranioplasty ...
Lacalle-Aurioles María M 1] Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain [2] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain [3] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, - - 2014
The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) than cerebral blood volume (CBV) and whether cortical atrophy is more associated with decreased CBV or with decreased CBF. We compared measurements of CBV, CBF, ...
Helton Kathleen J KJ Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, - - 2014
Elevated cerebral blood flow (CBF) in sickle cell anemia (SCA) is an adaptive pathophysiologic response associated with decreased vascular reserve and increased risk for ischemia. We compared manual (M) and semiautomated (SA) vascular territory delineation to facilitate standardized evaluation of CBF in children with SCA. ASL perfusion values from 21 ...
Willie Christopher K CK University of British Columbia Okanagan, - - 2014
Herein we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature, and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detail any one mechanism or ...
Muir Eric R ER Department of Ophthalmology, Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, - - 2014
Magnetic resonance imaging can be utilized as a quantitative and noninvasive method to image cerebral blood flow. The two most common techniques used to detect cerebral blood flow are dynamic susceptibility contrast (DSC) perfusion MRI and arterial spin labeling perfusion MRI. Herein we describe the use of these two techniques ...
Ding Bei B Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of - - 2014
A three-dimensional (3D) continuous pulse arterial spin labeling (ASL) technique was used to investigate cerebral blood flow (CBF) changes in patients with Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI), and age- and sex-matched healthy controls. Three groups were recruited for comparison, 24 AD patients, 17 MCI patients, and 21 ...
Isachenko Vladimir V Department of Obstetrics and Gynecology, Cologne University, Kerpener Stra β e 34, 50931 Cologne, - - 2014
These experiments were performed to test the perfusion of ovine as a model for human ovaries by cryoprotectants in vivo at high temperature when the permeability of capillaries is high and when blood is insensibly replaced by the solution of cryoprotectants. By our hypothetical supposition, ovaries could be saturated by ...
Sauerbrey Anika A 0000-0003-0912-7326 Radiation and Tumor Clinic, Essen University Hospital, Hufelandstraße. 55, 45147 Essen, - - 2014
The aim of the study was to develop a suitable animal model for validating dynamic contrast-enhanced magnetic resonance imaging perfusion measurements. A total of 8 pigs were investigated by DCE-MRI. Perfusion was determined on the hind leg musculature. An ultrasound flow probe placed around the femoral artery provided flow measurements ...
Akuthota Praveen P Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, KSB 23, 330 Brookline Avenue, Boston, 02215, MA, USA, - - 2014
Eosinophils are granulocytes integral to allergic inflammation and parasitic responses and comprise 1-4 % of the circulating leukocytes in human beings under normal conditions. Isolation of human eosinophils allows for ex vivo and in vitro experimentation, providing a valuable tool for the study of allergic mechanisms. Here, we describe a ...
Noh Seung-Hee SH Department of Meridian and Acupoint, College of Oriental Medicine, Daejeon University, Daejeon, South Korea; Department of Acupuncture & Moxibustion Medicine, Korean Medicine Hospital, Pusan National University, Yangsan, South - - 2014
This study aims to investigate the possible differences in skin temperature and blood perfusion changes between single and triple moxibustion. Thirty healthy volunteers were randomly divided into two groups: a triple moxibustion group (n=15) received indirect moxibustion on CV12 for 30min and a single moxibustion group (n=15) for 10min. After ...
Kellner Elias E Department of Radiology - Medical Physics, Medical Center - University of Freiburg, Freiburg, - - 2013
We recently presented a method for the quantitative measurement of the arterial input function which allows for determination of absolute cerebral blood flow (CBF) values without adjustable parameters. The aim of the present work is to estimate absolute CBF values by using this new technique and to compare it with ...
Kelley Dale D Department of Animal Sciences, University of Florida, Gainesville, Florida, USA. Electronic address: - - 2013
Supplementation with l-arginine can increase uterine arterial blood flow and vascular perfusion of the preovulatory follicle in mares. Increased vascular perfusion of the preovulatory follicle has been correlated with successful pregnancy in mares. The objective of this study was to determine if supplemental l-arginine would increase ovarian arterial blood flow, ...
Jackman Katherine K Weill Cornell Medical College, Brain and Mind Research Institute, 407 East 61st St, New York, New York, United States, 10065 ; - - 2013
Significance: The brain has high energetic requirements and is therefore highly dependent on adequate cerebral blood supply. In order to compensate for dangerous fluctuations in cerebral perfusion, the circulation of the brain has evolved intrinsic safeguarding measures. Recent advances & critical issues: The vascular network of the brain incorporates a ...
Cremers Charlotte H P - - 2013
Delayed cerebral ischemia (DCI) is at presentation a diagnosis per exclusionem, and can only be confirmed with follow-up imaging. For treatment of DCI a diagnostic tool is needed. We performed a systematic review to evaluate the value of CT perfusion (CTP) in the prediction and diagnosis of DCI. We searched ...
Kalder Johannes - - 2013
Extracorporeal circulation (ECC) is regularly applied to maintain organ perfusion during major aortic and cardiovascular surgery. During thoracoabdominal aortic repair, ECC-driven selective visceral arterial perfusion (SVP) results in changed microcirculatory perfusion (shift from the muscularis toward the mucosal small intestinal layer) in conjunction with macrohemodynamic hypoperfusion. The underlying mechanism, however, ...
Immink Rogier Vincent - - 2013
This review summarizes the evidence for an association between hyperventilation (HV)-induced hypocapnia and a reduction in cerebral perfusion leading to syncope defined as transient loss of consciousness (TLOC). The cerebral vasculature is sensitive to changes in both the arterial carbon dioxide (PaCO2) and oxygen (PaO2) partial pressures so that hypercapnia/hypoxia ...
Kock Linda M - - 2013
Flow-perfusion is being promoted as a way to grow tissue-engineered cartilage in vitro. Yet, there is a concern that flow-perfusion may induce unwanted mechanical effects on chondrogenesis and terminal differentiation. Therefore, the aim of this study is to evaluate the effect of fluid flow on chondrogenesis and chondrocyte hypertrophy of ...
Mücke Thomas T Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, - - 2014
The aim of this study was to evaluate perioperative flap perfusion using noninvasive monitoring with a laser-Doppler flowmetry and spectrophotometry unit (O2C) and identify whether perioperative blood flow, velocity, hemoglobin level (Hb), and oxygen saturation (SO2 ) measured could be used as indicators of free flap success. Measurements of blood ...
Douglas Helen E HE Canniesburn Plastic Surgery Unit, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK. Electronic address: - - 2014
DIEP flaps are a popular choice for autologous breast reconstruction, though many surgeons routinely discard zone IV, limiting transferrable tissue. We investigated the effect of altering number and location of perforators supplying the flap on total pedicle flow and perfusion of skin and fat of zone IV. 20 cranially-based abdominal ...
Shin Hwa Kyoung - - 2013
Hyperlipidemia is a major cardiovascular risk factor associated with progressive cerebrovascular dysfunction and diminished collateral perfusion in stroke. Rho-associated kinase (ROCK) may be an important mediator of hyperlipidemic vascular dysfunction. We tested the efficacy of acute or chronic ROCK inhibition on the size of dynamic perfusion defect using laser speckle ...
Weinberg Jordan A JA From the Department of Surgery (J.A.W., L.J.M., J.M.A., C.A.G., L.E.H., M.A.C., T.C.F.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Surgery (P.A.M., M.J.V., J.D.K., L.W.R.), University of Alabama at Birmingham, Birmingham, Alabama S.R.B. is from the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Pathology (R.P.P.), University of Alabama at Birmingham, Birmingham, - - 2013
The transfusion of relatively older red blood cells (RBCs) has been associated with both morbidity and mortality in trauma patients in observational studies. Although the mechanisms responsible for this phenomenon remain unclear, alterations in the microcirculation as a result of the transfusion of relatively older blood may be a causative ...
Dai Dong Wei - - 2013
To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and ...
Kawaji Hiroshi - - 2013
Preoperative embolization changes the amount of blood flow and pattern of flow distribution in meningioma. Tumor blood flow was investigated in eight meningioma patients before and after embolization using arterial spin-labeling (ASL) perfusion imaging. Although blood flow was significantly reduced in the whole tumor after embolization, changes in flow distribution ...
You Seung-Hoon SH Department of Neurosurgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, - - 2013
Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular ...
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