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Endo Kazuhiro K Departments of *Surgery †Radiology ‡The Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, - - 2014
The goal of this study is to examine changes in pancreatic perfusion due to pneumoperitoneum using perfusion CT in vivo. Three pigs were studied. Under general anesthesia, pneumoperitoneum was induced to 16 mm Hg. Perfusion CT scans were acquired at a rate of 1 image per 2 seconds for 60 ...
Thierfelder Kolja M KM From the Department of Clinical Radiology (K.M.T., A.B.B., W.H.S., M.A., M.F.R.), Department of Neurology (C.O., A.S., L.v.B.), Institute for Stroke and Dementia Research (C.O.), and Department of Neuroradiology (H.J.), Ludwig-Maximilians-University of Munich Hospitals, Munich, - - 2014
Vertebral artery hypoplasia (VAH) is supposed to be a risk factor for posterior circulation ischemia (PCI), particularly in the territory of the posterior inferior cerebellar artery (PICA). The aim of our study was to determine whether VAH impedes perfusion in the dependent PICA territory even in the absence of manifest ...
Mak Henry Ka-Fung HK Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong SAR, - - 2014
Background: Structural magnetic resonance imaging has been employed for evaluation of medial temporal atrophy in patients with Alzheimer's disease (AD). Arterial spin labeling (ASL) technique could detect cerebral perfusion abnormalities in AD. Objective: We hypothesized that combination of hippocampal volumetry and cerebral blood flow yield higher accuracy than either method ...
Le Heron Campbell J CJ New Zealand Brain Research Institute, Christchurch, New - - 2014
Emerging evidence suggests that Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) share neurodegenerative mechanisms. We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI). In total, 17 AD, 20 PDD, and 37 matched healthy controls completed ASL and structural MRI, ...
Foppa C C Division of Colon and Rectal Surgery, Health Science Center, State University of New York, T18, Suite 046B, Stony Brook, NY, 11794-8191, - - 2014
Assessing the blood supply of the bowel is a difficult task even for experienced surgeons. Laser-assisted indocyanine green (ICG) fluorescent dye angiography provides intraoperative visual assessment of blood flow to the bowel wall and surrounding tissues, allowing for modification to the surgical plan, which can reduce the risk of postoperative ...
Liang Meng-Ya MY 1Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. 2Department of Anesthesiology, Heart Center, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
This study aimed to investigate whether selective antegrade cerebral perfusion or retrograde cerebral perfusion is a better technique for brain protection in deep hypothermic circulatory arrest by obtaining metabolic evidence from microdialysis. Randomized, animal study. Assisted circulation laboratory. Eighteen piglets of either sex (9.8 ± 3.1 kg). Animals were randomly ...
Carter Howard H HH University of Western - - 2014
Episodic increases in cerebrovascular perfusion and shear stress may have beneficial impacts on endothelial function that improve brain health. We hypothesised that water immersion to the level of the right atrium in humans would increase cerebral perfusion. We continuously measured, in 9 young (mean±SD, 24.6 ± 2.0 yrs) healthy men, ...
Donati Abele - - 2014
Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion increases oxygen (O2)-delivery but rarely improves tissue O2 uptake in septic patients. Possible causes include RBC alterations due to prolonged storage or residual leukocyte-derived inflammatory mediators. The aim of this study was to compare the effects of ...
Oskarsson Eva E Örebro University, School of Health and Medical Sciences, Örebro, - - 2014
The aim of this study was to examine possible signs of impairment of the microcirculation in the lower extremities of female patients suffering from primary restless legs syndrome/Willis-Ekbom disease. This study was performed in eight female patients, mean age 48 years (range 21-65), diagnosed with primary restless legs syndrome but ...
Hales Patrick W PW Imaging and Biophysics Unit, Institute of Child Health, University College London, London, - - 2014
The human brain changes structurally and functionally during adolescence, with associated alterations in cerebral perfusion. We performed dynamic arterial spin labeling (ASL) magnetic resonance imaging in healthy subjects between 8 and 32 years of age, to investigate changes in cerebral hemodynamics during normal development. In addition, an inversion recovery sequence ...
Siemonsen Susanne S Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
The aim of this study is to investigate whether different spatial perfusion-deficit patterns, which indicate differing compensatory mechanisms, can be recognized and used to predict recanalization success of intravenous fibrinolytic therapy in acute stroke patients. Twenty-seven acute stroke data sets acquired within 6 hours from symptom onset including diffusion- (DWI) and ...
Obeid Layal L 1] INSERM, U836, Grenoble-Institut des Neurosciences, Equipe 6, Grenoble Cedex 9, France [2] Université Joseph Fourier, Grenoble Cedex 9, - - 2014
Contrast-enhanced radiotherapy is an innovative treatment that combines the selective accumulation of heavy elements in tumors with stereotactic irradiations using medium energy X-rays. The radiation dose enhancement depends on the absolute amount of iodine reached in the tumor and its time course. Quantitative, postinfusion iodine biodistribution and associated brain perfusion ...
Sarubbo Silvio S Neurosurgery Unit, Department of Neurosciences, "S. Chiara" Hospital, APSS Trento, Trento, - - 2014
Little is known about hemodynamic disturbances affecting cerebral hemispheres in traumatic brain injury (TBI) after cranioplasty. We prospectively investigated six stable TBI patients who underwent cranioplasty more than 90 days after effective decompressive craniectomy. Computerized tomography perfusion (CTP) studies and evaluation of clinical outcome were performed for each patient before cranioplasty ...
Lacalle-Aurioles María M 1] Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain [2] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain [3] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, - - 2014
The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) than cerebral blood volume (CBV) and whether cortical atrophy is more associated with decreased CBV or with decreased CBF. We compared measurements of CBV, CBF, ...
Willie Christopher K CK University of British Columbia Okanagan, - - 2014
Herein we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature, and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detail any one mechanism or ...
Muir Eric R ER Department of Ophthalmology, Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, - - 2014
Magnetic resonance imaging can be utilized as a quantitative and noninvasive method to image cerebral blood flow. The two most common techniques used to detect cerebral blood flow are dynamic susceptibility contrast (DSC) perfusion MRI and arterial spin labeling perfusion MRI. Herein we describe the use of these two techniques ...
Ding Bei B Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of - - 2014
A three-dimensional (3D) continuous pulse arterial spin labeling (ASL) technique was used to investigate cerebral blood flow (CBF) changes in patients with Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI), and age- and sex-matched healthy controls. Three groups were recruited for comparison, 24 AD patients, 17 MCI patients, and 21 ...
Isachenko Vladimir V Department of Obstetrics and Gynecology, Cologne University, Kerpener Stra β e 34, 50931 Cologne, - - 2014
These experiments were performed to test the perfusion of ovine as a model for human ovaries by cryoprotectants in vivo at high temperature when the permeability of capillaries is high and when blood is insensibly replaced by the solution of cryoprotectants. By our hypothetical supposition, ovaries could be saturated by ...
Sauerbrey Anika A 0000-0003-0912-7326 Radiation and Tumor Clinic, Essen University Hospital, Hufelandstraße. 55, 45147 Essen, - - 2014
The aim of the study was to develop a suitable animal model for validating dynamic contrast-enhanced magnetic resonance imaging perfusion measurements. A total of 8 pigs were investigated by DCE-MRI. Perfusion was determined on the hind leg musculature. An ultrasound flow probe placed around the femoral artery provided flow measurements ...
Noh Seung-Hee SH Department of Meridian and Acupoint, College of Oriental Medicine, Daejeon University, Daejeon, South Korea; Department of Acupuncture & Moxibustion Medicine, Korean Medicine Hospital, Pusan National University, Yangsan, South - - 2014
This study aims to investigate the possible differences in skin temperature and blood perfusion changes between single and triple moxibustion. Thirty healthy volunteers were randomly divided into two groups: a triple moxibustion group (n=15) received indirect moxibustion on CV12 for 30min and a single moxibustion group (n=15) for 10min. After ...
Kellner Elias E Department of Radiology - Medical Physics, Medical Center - University of Freiburg, Freiburg, - - 2013
We recently presented a method for the quantitative measurement of the arterial input function which allows for determination of absolute cerebral blood flow (CBF) values without adjustable parameters. The aim of the present work is to estimate absolute CBF values by using this new technique and to compare it with ...
Kelley Dale D Department of Animal Sciences, University of Florida, Gainesville, Florida, USA. Electronic address: - - 2013
Supplementation with l-arginine can increase uterine arterial blood flow and vascular perfusion of the preovulatory follicle in mares. Increased vascular perfusion of the preovulatory follicle has been correlated with successful pregnancy in mares. The objective of this study was to determine if supplemental l-arginine would increase ovarian arterial blood flow, ...
Jackman Katherine K Weill Cornell Medical College, Brain and Mind Research Institute, 407 East 61st St, New York, New York, United States, 10065 ; - - 2013
Significance: The brain has high energetic requirements and is therefore highly dependent on adequate cerebral blood supply. In order to compensate for dangerous fluctuations in cerebral perfusion, the circulation of the brain has evolved intrinsic safeguarding measures. Recent advances & critical issues: The vascular network of the brain incorporates a ...
Cremers Charlotte H P - - 2013
Delayed cerebral ischemia (DCI) is at presentation a diagnosis per exclusionem, and can only be confirmed with follow-up imaging. For treatment of DCI a diagnostic tool is needed. We performed a systematic review to evaluate the value of CT perfusion (CTP) in the prediction and diagnosis of DCI. We searched ...
Kalder Johannes - - 2013
Extracorporeal circulation (ECC) is regularly applied to maintain organ perfusion during major aortic and cardiovascular surgery. During thoracoabdominal aortic repair, ECC-driven selective visceral arterial perfusion (SVP) results in changed microcirculatory perfusion (shift from the muscularis toward the mucosal small intestinal layer) in conjunction with macrohemodynamic hypoperfusion. The underlying mechanism, however, ...
Immink Rogier Vincent - - 2013
This review summarizes the evidence for an association between hyperventilation (HV)-induced hypocapnia and a reduction in cerebral perfusion leading to syncope defined as transient loss of consciousness (TLOC). The cerebral vasculature is sensitive to changes in both the arterial carbon dioxide (PaCO2) and oxygen (PaO2) partial pressures so that hypercapnia/hypoxia ...
Kock Linda M - - 2013
Flow-perfusion is being promoted as a way to grow tissue-engineered cartilage in vitro. Yet, there is a concern that flow-perfusion may induce unwanted mechanical effects on chondrogenesis and terminal differentiation. Therefore, the aim of this study is to evaluate the effect of fluid flow on chondrogenesis and chondrocyte hypertrophy of ...
Douglas Helen E HE Canniesburn Plastic Surgery Unit, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK. Electronic address: - - 2014
DIEP flaps are a popular choice for autologous breast reconstruction, though many surgeons routinely discard zone IV, limiting transferrable tissue. We investigated the effect of altering number and location of perforators supplying the flap on total pedicle flow and perfusion of skin and fat of zone IV. 20 cranially-based abdominal ...
Shin Hwa Kyoung - - 2013
Hyperlipidemia is a major cardiovascular risk factor associated with progressive cerebrovascular dysfunction and diminished collateral perfusion in stroke. Rho-associated kinase (ROCK) may be an important mediator of hyperlipidemic vascular dysfunction. We tested the efficacy of acute or chronic ROCK inhibition on the size of dynamic perfusion defect using laser speckle ...
Dai Dong Wei - - 2013
To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and ...
Kawaji Hiroshi - - 2013
Preoperative embolization changes the amount of blood flow and pattern of flow distribution in meningioma. Tumor blood flow was investigated in eight meningioma patients before and after embolization using arterial spin-labeling (ASL) perfusion imaging. Although blood flow was significantly reduced in the whole tumor after embolization, changes in flow distribution ...
Weinberg Jordan A - - 2013
The transfusion of relatively older red blood cells (RBCs) has been associated with both morbidity and mortality in trauma patients in observational studies. Although the mechanisms responsible for this phenomenon remain unclear, alterations in the microcirculation as a result of the transfusion of relatively older blood may be a causative ...
You Seung-Hoon SH Department of Neurosurgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, - - 2013
Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular ...
Cypess Aaron M AM Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, - - 2013
For brown adipose tissue (BAT) to be effective at consuming calories, its blood flow must increase enough to provide sufficient fuel to sustain energy expenditure and also transfer the heat created to avoid thermal injury. Here we used a combination of human and rodent models to assess changes in BAT ...
Johnston Megan E - - 2013
To develop quantitative cerebral blood flow (CBF) imaging using pseudo-continuous arterial spin labeling (PCASL) in swine, accounting for their cerebrovascular anatomy and physiology. Five domestic pigs (2.5-3 months, 25 kg) were used in these studies. The orientation of the labeled arteries, T1bl , M0bl , and T1gm were measured in ...
Kjørstad Asmund - - 2013
To quantitatively evaluate lung perfusion using Fourier decomposition perfusion MRI. The Fourier decomposition (FD) method is a noninvasive method for assessing ventilation- and perfusion-related information in the lungs, where the perfusion maps in particular have shown promise for clinical use. However, the perfusion maps are nonquantitative and dimensionless, making follow-ups ...
Fredly Siv - - 2013
Despite microcirculation's fundamental role, assessments of its function are limited. We explored the applicability of Computer Assisted Video Microscope (CAVM), Laser Doppler Perfusion Measurements (LDPM) and Diffuse Reflectance Spectroscopy (DRS) to study skin microvascular morphology, perfusion and oxygen saturation in twenty-five healthy newborns day 1-3 of life. Results: Day 1-3 ...
Saiki Hirofumi - - 2013
Recent studies have shown that bilateral pulmonary artery banding (bil-PAB) for hypoplastic left heart syndrome (HLHS) is not superior to the neonatal Norwood procedure in terms of overall mortality and neurodevelopmental outcome. We tested our hypothesis that bil-PAB is associated with negative hemodynamic effects on cerebral circulation. The acute effects ...
Worner Murray - - 2013
We have designed a laboratory extracorporeal normothermic blood perfusion system for whole organs (e.g., kidney) that achieves pulsatile flow, low levels of hemolysis, and a blood priming volume of 60 mL or less. Using this uniquely designed extracorporeal circuit, we have achieved perfusion of two isolated ex vivo constructs. In the ...
Feng Qi - - 2013
Although recent studies have clearly demonstrated functional and structural abnormalities in adolescents with internet gaming addiction (IGA), less is known about how IGA affects perfusion in the human brain. We used pseudocontinuous arterial spin-labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) to measure the effects of IGA on resting brain ...
Ferré J-C - - 2013
Arterial spin labeling (ASL) perfusion is a MRI technique to quantify tissue blood flow. ASL is a non-invasive technique that labels the protons in the arterial blood by radiofrequency pulses, without the exogenous injection of contrast media. This article has three goals: 1) present the principles of ASL perfusion, the ...
Svolos Patricia - - 2013
The purpose was to investigate the contribution of machine learning algorithms using diffusion and perfusion techniques in the differentiation of atypical meningiomas from glioblastomas and metastases. Apparent diffusion coefficient, fractional anisotropy, and relative cerebral blood volume were measured in different tumor regions. Naive Bayes, k-Nearest Neighbor, and Support Vector Machine ...
Remus C C - - 2013
The steepest slope model is a numerically robust and fast method for perfusion quantification. The purpose of this study was to evaluate if the steepest slope model can be used for quantifying placental perfusion in mice based on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) datasets. T1-weighted DCE MRI was ...
O'Phelan Kristine - - 2013
Substance abuse is a frequent comorbid condition among patients with traumatic brain injury (TBI), but little is known about its potential additive or interactive effects on tissue injury or recovery from TBI. This study aims to evaluate changes in regional metabolism and cerebral perfusion in subjects who used methamphetamine (METH) ...
Barbier E L - - 2013
T2*-weighted perfusion MRI is based on the so-called "first passage" approach: the modifications in the T2-weighted MRI signal are followed during the first passage of a bolus of contrast agent. The pixel-by-pixel analysis of the curves is used to obtain parametric maps (time of arrival, time of the peak, mean ...
Vogt Stephan - - 2013
Blood flow in various organs is determined by an autoregulatory mechanism that guarantees constant organ perfusion over a wide range of arterial blood pressure changes. This physiological principle has been proven for the kidney, brain and intestinal tract, but so far not for bone. This study was carried out to ...
Jo S Y - - 2013
BACKGROUND AND PURPOSE:Increased angiogenesis in head and neck squamous cell carcinoma correlates to more aggressive tumors with increased morbidity. Because both elevated blood flow and high serum CXCL8 levels are correlated with increased angiogenesis, our objective was to see if elevated blood flow measured with CT perfusion correlated with CXCL8 ...
Daly Amanda - - 2013
It was previously demonstrated that red blood cell (RBC) deformability progressively decreases during storage along with other changes in RBC mechanical properties. Recently, we reported that the magnitude of changes in RBC mechanical fragility associated with blood bank storage in a variety of additive solutions was strongly dependent on the ...
Inamori Syuji - - 2013
Currently, nonpulsatile selective cerebral perfusion for cerebroprotection against thoracic aortic aneurysm is used in clinical settings. We performed synchrotron radiation microangiography to determine the effects on selective cerebral perfusion modulation by pulsatile flow. We established cerebral perfusion at normothermia and severe hypothermia in anesthetized rats, during which cerebral angiography was ...
Chau Katherine H - - 2013
Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that was developed in the 1950s and popularized in the 1970s. It has become one of the three most common cerebral protection techniques currently used in aortic arch surgeries, with the other two being antegrade cerebral perfusion (ACP) and retrograde ...
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