Search Results
Results 1 - 50 of 1403
1 2 3 4 5 6 7 8 9 10 >
Arthur Connie M CM The Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, - - 2015
Over a century ago, Karl Landsteiner discovered that blood group antigens could predict the immunological outcome of red blood cell transfusion. While the discovery of ABO(H) blood group antigens revolutionized transfusion medicine, many questions remain regarding the development and regulation of naturally occurring anti-blood group antibody formation. Early studies suggested ...
Keller Emanuela E Neurocritical Care Unit, Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, Zuerich, CH-8091, Switzerland, - - 2015
Detection of delayed cerebral ischemia (DCI) in high-grade subarachnoid haemorrhage (SAH) is an unsolved issue. Conventional near-infrared spectroscopy (NIRS) with optodes applied over the skin is controversial because the NIRS signal is contaminated by extracerebral tissue. The objective is to quantify and subtract the contribution from extracerebral tissue from the ...
Good Christopher C a The Conservation Fund's Freshwater Institute, 1098 Turner Road , Shepherdstown , West Virginia 25443 , - - 2014
Abstract During a controlled 6-month study using six replicated water recirculation aquaculture systems (WRASs), it was observed that Rainbow Trout Oncorhynchus mykiss in all WRASs exhibited a higher-than-normal prevalence of side swimming (i.e., controlled, forward swimming but with misaligned orientation such that the fish's sagittal axis is approximately parallel to ...
Suzuki Toyofumi T Laboratory of Pharmaceutics, Nihon University School of Pharmacy, 7-7-1 Narashinodai, Funabashi, Chiba, 274-8555, - - 2014
The purpose of this study was to characterize the brain-to-blood efflux transport of amantadine across the blood-brain barrier (BBB). The apparent in vivo efflux rate constant for [(3) H]amantadine from the rat brain (keff ) was found to be 1.53 × 10(-2)  min(-1) after intracerebral microinjection using the Brain Efflux Index method. ...
Liu Xiuyun X Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, - - 2014
The impulse response (IR)-based autoregulation index (ARI) allows for continuous monitoring of cerebral autoregulation using spontaneous fluctuations of arterial blood pressure (ABP) and cerebral flow velocity (FV). We compared three methods of autoregulation assessment in 288 traumatic brain injury (TBI) patients managed in the Neurocritical Care Unit: (1) IR-based ARI; ...
Schwarz Janina C V JC Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Endothelial shear stress (ESS) dynamics are a major determinant of atherosclerosis development. The frequently used Poiseuille method to estimate ESS dynamics has important limitations. Therefore, we investigated whether Womersley flow may provide a better alternative for estimation of ESS while requiring equally simple hemodynamic parameters. Common carotid blood flow, centerline ...
Feng Lei L Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, - - 2014
To obtain single-source short tandem repeat (STR) profiles in trace female/male blood mixture samples, we combined florescence in situ hybridization (FISH), laser microdissection, and low volume PCR (LV-PCR) to isolate male/female cells and improve sensitivity. The results showed that isolation of as few as 10 leukocytes was sufficient to yield ...
Watt Andrew D AD The Florey Institute of Neuroscience and Mental Health, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia The Neuroproteomics Platform, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, VIC, - - 2014
Biomarkers enabling the preclinical identification of Alzheimer's disease (AD) remain one of the major unmet challenges in the field. The blood cellular fractions offer a viable alternative to current cerebrospinal fluid and neuroimaging modalities. The current study aimed to replicate our earlier reports of altered binding within the AD-affected blood ...
Sobczyk Olivia O Institute of Medical Science, University of Toronto, Toronto, Ontario, - - 2014
Attribution of vascular pathophysiology to reductions in cerebrovascular reactivity (CVR) is confounded by subjective assessment and the normal variation between anatomic regions. This study aimed to develop an objective scoring assessment of abnormality. CVR was measured as the ratio of the blood-oxygen-level-dependent magnetic resonance signal response divided by an increase ...
Gunier Robert - - 2014
Manganese (Mn) is an essential nutrient but at high exposure levels is a neurotoxicant. There is no well-validated biomarker to assess perinatal Mn exposure. A total of 75 mother-child pairs provided blood, urine, and/or deciduous tooth samples. We analyzed Mn in dentin and enamel of shed teeth; maternal, cord, and ...
Chiu Chih-Yung CY Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Pulmonology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, - - 2014
The association between vitamin D status at birth and allergen sensitizations is uncertain. The aim of this study was to investigate the relationship of cord blood vitamin D status with allergen sensitizations and the development of atopic diseases in early childhood. Children aged 0 through 4 years from a birth ...
Shiga Yukihiro Y Department of Ophthalmology, Tohoku University Graduate School of Medicine , Miyagi , Japan - - 2014
Abstract Purpose: To evaluate laser speckle flowgraphy (LSFG) measurements of the optic nerve head (ONH) blood flow (BF) response to hyperoxia. Methods: This prospective study included 30 eyes of 30 healthy volunteers (mean age: 28.5 ± 4.0, male:female = 13:17). The testing protocol had three phases: in the baseline phase, subjects breathed room air; ...
Jiang Fang-Zhen FZ Department of Plastic and Reconstructive Surgery, Second Affiliated Hospital, Zhejiang University, School of Medicine, No. 88 Jiefang road, Hangzhou, 310009, - - 2014
A tourniquet is commonly used in total knee arthroplasty (TKA). However, the effectiveness and safety of tourniquets are debated. We performed this study to investigate whether patients benefit from the use of tourniquets in TKA. The literature search was conducted using PubMed, Cochrane Library, MEDLINE, Embase, and other medical databases. ...
Fernandez-Flores Angel A Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, - - 2014
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B- and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors ...
Christensen R D RD 1] The Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, UT, USA [2] Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA [3] Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, - - 2014
Objective:Neonates with undiagnosed hereditary spherocytosis (HS) are at risk for developing hazardous hyperbilirubinemia and anemia. Making an early diagnosis of HS in a neonate can prompt anticipatory guidance to prevent these adverse outcomes. A recent comparison study showed that a relatively new diagnostic test for HS, eosin-5-maleimide (EMA)-flow cytometry, performs ...
Zanderigo Francesca F Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Columbia University, New York, New York, - - 2014
Full quantification of a positron emission tomography (PET) radioligand binding to its target is preferred because it requires the fewest assumptions, but generally involves measuring the concentration of free radioligand in the arterial plasma by collecting blood samples from the subject's radial artery during the scan, and performing metabolite analysis. ...
Shivaprasad Ks K Department of Endocrinology & Metabolism, Institute of Post-Graduate Medical Education & Research (IPGMER) and Seth Sukhlal Karnani Memorial (SSKM) Hospital, 244 AJC Bose Road, Calcutta-700020, - - 2014
Objective: Cardiovascular events are the commonest cause of mortality in Cushing's syndrome (CS). This study aimed to evaluate the impact of novel factors on atherosclerosis in endogenous CS.Methods: Twenty-two female patients with CS and 33 normal female controls underwent evaluation of fibrinogen, high sensitivity c-reactive protein (hsCRP), inflammatory cytokines [interleukin ...
Hara Manabu M Department of Orthopaedic Surgery, Toho University School of Medicine, Tokyo, - - 2014
The aim of this study was to investigate whether differences in the methods of approach to the vertebral arch influence the invasiveness of conventional discectomy and microendoscopic discectomy (MED). In this study, 41 Wistar rats were divided into four groups: controls (no surgery) (n = 10), shams (skin incision only) (n = 11), MED ...
Reichert Christof C Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, - - 2014
Objective-To evaluate the use of a micro-lightguide tissue spectrophotometer for measurement of tissue oxygenation and blood flow in the small and large intestines of horses under anesthesia. Animals-13 adult horses without gastrointestinal disease. Procedures-Horses were anesthetized and placed in dorsal recumbency. Ventral midline laparotomy was performed. Intestinal segments were exteriorized ...
Cândido Thaísa D TD Departments of Anesthesiology, São Paulo State University, Botucatu, SP, 18618-970, - - 2014
Objective-To evaluate the effects of a dexmedetomidine constant rate infusion (CRI) and atropine on changes in global perfusion variables induced by hemorrhage and volume replacement (VR) in isoflurane-anesthetized dogs. Animals-8 adult dogs. Procedures-Each dog was anesthetized twice, with a 2-week interval between anesthetic sessions. Anesthesia was maintained with 1.3 times ...
Grubb Tamara L TL Department of Animal Environment and Health, Swedish University of Agricultural Sciences, 53223 Skara, Sweden., Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA - - 2014
Objective-To image the spatial distribution of pulmonary blood flow by means of scintigraphy, evaluate ventilation-perfusion (VA/Q) matching and pulmonary blood shunting (Qs/Qt) by means of the multiple inert gas elimination technique (MIGET), and measure arterial oxygenation and plasma endothelin-1 concentrations before, during, and after pulse-delivered inhaled nitric oxide (PiNO) administration ...
Sakano Ryosuke R Graduate School of Health Sciences, Hokkaido University, North-12 West-5, Kita-ku, Sapporo, 060-0812, - - 2014
Ultrasound allows the detection and grading of inflammation in rheumatology. Despite these advantages of ultrasound in the management of rheumatoid patients, it is well known that there are significant machine-to-machine disagreements regarding signal quantification. In this study, we tried to calibrate the power Doppler (PD) signal of two models of ...
de Groot Martijn J MJ 1] Department of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands [2] Department of Digestive and Metabolic Diseases, Center for Liver, University Medical Center Groningen, University of Groningen, Groningen, The - - 2014
In phenylketonuria, elevated plasma phenylalanine concentrations may disturb blood-to-brain large neutral amino acid (LNAA) transport and cerebral protein synthesis (CPS). We investigated the associations between these processes, using data obtained by positron emission tomography with l-[1-(11)C]-tyrosine ((11)C-Tyr) as a tracer. Blood-to-brain transport of non-Phe LNAAs was modeled by the rate ...
Singh Abhay A Transfusion Medicine Department, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, - - 2014
Point-of-care testing (POCT) devices for determining pre-donation haemoglobin (Hb) concentrations mark the advent of advanced technology for blood banks. POCT devices have undergone several improvements including changes in testing methodology and size of device, befitting the needs of blood donors and blood banks in terms of safety and quality of ...
Green Benjamin Paul BP B Green, Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne , NE1 8ST, United Kingdom - - 2014
Background: The present study examined the agreement between fingertip-capillary and antecubital-venous measures of appetite-related peptides. Methods: Simultaneous fingertip-capillary and antecubital-venous blood samples were collected from 19 participants. Samples were obtained at baseline, 30, 60, 90 and 120 min following breakfast consumption for determination of plasma GLP-17-36, glucagon, insulin and leptin. ...
Mukerji Nitin N Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine, Stanford, - - 2014
OBJECT Hyperperfusion is believed to be the cause of transient neurological events (TNEs) in patients with moyamoya disease (MMD) who have undergone an extracranial-to-intracranial (EC-IC) bypass between the superficial temporal artery (STA) and the middle cerebral artery (MCA). The objective of this study was to evaluate this possibility by analyzing ...
Bragin Denis E DE Department of Neurosurgery - - 2014
OBJECT High-frequency pulsed electromagnetic field stimulation is an emerging noninvasive therapy being used clinically to facilitate bone and cutaneous wound healing. Although the mechanisms of action of pulsed electromagnetic fields (PEMF) are unknown, some studies suggest that its effects are mediated by increased nitric oxide (NO), a well-known vasodilator. The ...
Cornelis Marilyn C MC Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA - - 2014
Selenium (Se) is an essential trace element in human nutrition, but its role in certain health conditions, particularly among Se sufficient populations, is controversial. A genome-wide association study (GWAS) of blood Se concentrations previously identified a locus at 5q14 near BHMT. We performed a GW meta-analysis of toenail Se concentrations, ...
Burk S S Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, FAU Erlangen-Nürnberg, Erlangen, - - 2014
Buffy coat (BC) volume reduction was evaluated in leucapheresis (LA) harvests due to the target monocyte yield and the red blood cell (RBC) content. A packed erythrocyte volume (PEV) of 7·5 ml should not be exceeded to avoid RBC debulking with loss of leucocytes (WBCs) and the monocyte fraction during monocyte ...
Kempton Steve J SJ Division of Plastic and Reconstructive Surgery, University of Wisconsin Hospital and Clinics, Madison, - - 2014
The purpose of this study is to evaluate the use of the venous anastomotic Flow Coupler in monitoring free flaps used for breast reconstruction in a consecutive series of patients. Retrospective data were collected on patients undergoing free flap breast reconstruction from May 2012 to March 2014. The venous anastomotic ...
Krotov Grigory G Moscow Anti-Doping Centre, Elizavetinsky per. 10, Moscow, 105005, - - 2014
Homologous blood transfusion is a prohibited method of blood manipulation that can be used to increase the number of erythrocytes circulating in the blood stream resulting in an increased oxygen transport capacity. In doping controls, homologous blood transfusions are determined by means of a procedure based on the detection of ...
Fabjan Andrej A Institute of Physiology, Medical Faculty, University of Ljubljana, Slovenia - - 2014
Altered neurovascular coupling in migraineurs could be a consequence of impaired function of modulatory brainstem nuclei. The cold pressor test (CPT) should activate brainstem structures. We measured visually evoked cerebral blood flow velocity response (VEFR) to CPT in migraine. Twenty-three healthy volunteers and 29 migraineurs participated in the study. We ...
Kyrk Tobias T Departments of Public Health and Clinical Medicine, Umea University, Umea - - - 2014
Hemodialysis patients who are subject to increased risk of hemorrhage may need specific dialysis regimes to avoid bleeding. The aim of this study was to determine in vitro which of various anticoagulation options were most beneficial. 60 in vitro hemodialyses (HD) were performed in parallel using blood from healthy donors. ...
von Schweinitz Benjamin A BA Department of Emergency Medicine, San Antonio Military Medical Center, JBSA-Fort Sam Houston, TX, 78234, USA, - - 2014
Non-invasive hemoglobin measuring technology has potential for rapid, portable, and accurate way of providing identification of blood loss or anemia. Our objective is to determine if this technology is reliable in critically ill patients presenting to the Emergency Department. Prospective cross-sectional observational study was done at an urban level-one trauma ...
Kruse Nicholas T NT Cardiopulmonary and Metabolism Research Laboratory, Department of Kinesiology, University of Toledo, Toledo, OH, - - 2014
This study determined human skeletal muscle oxygenation dynamics during and after a single bout of self-administered stretching (SAS) of the plantar flexors. Nine healthy recreationally fit men (n = 7; age = 25·7 years) and women (n = 2; age = 23·5 years) performed two protocols: (i) one bout of SAS for 4 min and (ii) one bout of moderate intensity ...
Xu Feng F Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, - - 2014
While it is known that specific nuclei of the brain, for example hypothalamus, contain glucose-sensing neurons thus their activity is affected by blood glucose level, the effect of glucose modulation on whole-brain metabolism is not completely understood. Several recent reports have elucidated the long-term impact of caloric restriction on the ...
Simončič Urban U aJožef Stefan Institute, Ljubljana bThe Centre of Excellence for Biosensors, Instrumentation and Process Control - COBIK, Ajdovščina, Slovenia cUniversity of Bordeaux, CNRS, INCIA, UMR 5287, Talence, France dMolecular Imaging Branch, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, - - 2014
Quantitative PET studies often require the cumbersome and invasive procedure of arterial cannulation to measure the input function. This study sought to minimize the number of necessary blood samples by developing a factor-analysis-based image-derived input function (IDIF) methodology for dynamic PET brain studies. IDIF estimation was performed as follows: (a) ...
Fryer Simon S a School of Sport and Exercise , University of Gloucester , Gloucester , - - 2014
Abstract Currently, the physiological mechanisms that allow elite level climbers to maintain intense isometric contractions for prolonged periods of time are unknown. Furthermore, it is unclear whether blood flow or muscle oxidative capacity best governs performance. This study aimed to determine the haemodynamic kinetics of 2 forearm flexor muscles in ...
Sonoda Shozo S Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences , Sakuragaoka, Kagoshima , - - 2014
Abstract Background/purpose: To see the relationship between blood components and optical coherence tomography (OCT) reflectivity using an animal model in which the aqueous humor was substituted by different experimental solutions without changing the integrity of the retina. Materials and methods: The aqueous humor of an enucleated swine eye was replaced ...
Yildiz Ali A Department of Cardiology, Harran University School of Medicine, Sanliurfa, Turkey - - 2014
We aimed to assess the impact of meteorological variables on coronary blood flow (CBF). Coronary blood flow was evaluated using the thrombolysis in myocardial infarction frame count (TFC). The association of CBF with meteorological parameters such as temperature, relative humidity, total solar radiation, atmospheric pressure, wind velocity, and total sunshine ...
Sobolevsky Tim - - 2014
The laboratory anti-doping services during XXII Winter Olympic and XI Paralympic Games in Sochi in 2014 were provided by a satellite laboratory facility. In total, 2134 urine and 479 blood samples were analyzed during Olympic Games (OG), and 403 urine and 108 blood samples-during Paralympic Games (PG). The number of ...
Manjari Rao R Department of Veterinary Physiology & Climatology, College of Veterinary & Animal Sciences, GBPUAT, Pantnagar, 263145, Uttarakhand, - - 2014
Heat and humidity stress is a constant challenge to buffalo rearing under tropical climatic conditions. Heat shock proteins (HSPs) constitute a ubiquitous class of highly conserved proteins that contribute to cell survival during different conditions of stress. The present study was carried out in Tarai buffaloes to study the expression ...
Poon R R Private Practice in Oral Medicine Changchun, - - 2014
Background Burning mouth syndrome (BMS) is a chronic condition of burning of the tongue and oral mucosa. It is often accompanied with complaints of xerostomia, although it is unknown whether the dryness is a sensory change similar to the burning sensation or due to hyposalivation. To determine whether there is ...
Dawes Emeritus Colin EC Dept. of Oral Biology University of Manitoba Winnipeg, - - 2014
Background Burning mouth syndrome (BMS) is a chronic condition of burning of the tongue and oral mucosa. It is often accompanied with complaints of xerostomia, although it is unknown whether the dryness is a sensory change similar to the burning sensation or due to hyposalivation. To determine whether there is ...
Tar Moses M Department of Urology, Albert Einstein College of Medicine, New York, NY, - - 2014
Patients undergoing radical prostatectomy (RP) suffer from erectile dysfunction (ED) refractory to phosphodiesterase 5 inhibitors, which act downstream of cavernous nerve (CN)-mediated release of nitric oxide (NO). Direct delivery of NO to the penis could potentially circumvent this limitation. This study aimed to determine if topically applied NO-releasing nanoparticles (NO-NPs) ...
Barzilay Eran E Department of obstetrics and gynecology, Sheba medical center, Tel-Hashomer, Ramat-Gan, 52621, Israel. Affiliated to the Sackler School of Medicine, Tel Aviv University, - - 2014
Blood-vessel resistance is assessed by flow velocity indexes. However, the actual resistance should be more strongly correlated with vessel diameter rather than variations in flow velocity. We aimed to determine the utility of middle cerebral artery (MCA) diameter measurement as a tool for evaluating brain sparing effect in IUGR discordant ...
Saini Shiv Sajan SS Neonatal Unit, Department of Paediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, - - 2014
We thank Schneider and colleagues (1) for an interesting paper. The authors have shown significant differences in cerebral tissue oxygenation levels among four commercially available NIRS devices.Different measurement intervals, light wavelengths used, trends or absolute value measurements, light pathway distance (depends on probe size and manufacturer), and algorithm of venous ...
Matysiak Edyta E Faculty of Chemistry, University of Warsaw, ul. Pasteura 1, PL-02-093 Warsaw, - - 2014
An effective, fast, facile and direct electrochemical method of determination of hemoglobin (Hb) in blood sample without any sample preparation is described. The method is accomplished by using the ferromagnetic electrode modifier (carbon-encapsulated iron nanoparticles) and an external magnetic field. The successful voltammetric determination of hemoglobin is achieved in PBS ...
Guan Stanford S Program in Public Health, Stony Brook University, United - - 2014
Although the benefits of fish consumption are widely recognized, seafood may also be a source of exposure to heavy metals such as cadmium. Many types of seafood are rich in cadmium, but bioavailability and potential for toxicity after consumption is less clear. This study investigates the relationship between seafood intake ...
Uekusa Hiroyuki H Department of Neurosurgery (Omori), School of Medicine, Faculty of Medicine, Toho University, Japan. Electronic address: - - 2014
To investigate the association between subarachnoid hemorrhage-induced delayed cerebral vasospasm (DCVS) and oxidative stress, an oxidation product, hydroperoxide, was measured in 3 specimens: peripheral arterial blood, cerebrospinal fluid (CSF), and internal jugular venous blood (IJVB). Hydroperoxide was measured using the diacron reactive oxygen metabolites (d-ROMs) test. The hydroperoxide levels were ...
1 2 3 4 5 6 7 8 9 10 >