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Arthur Connie M CM The Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, - - 2015
Over a century ago, Karl Landsteiner discovered that blood group antigens could predict the immunological outcome of red blood cell transfusion. While the discovery of ABO(H) blood group antigens revolutionized transfusion medicine, many questions remain regarding the development and regulation of naturally occurring anti-blood group antibody formation. Early studies suggested ...
Keller Emanuela E Neurocritical Care Unit, Department of Neurosurgery, University Hospital Zurich, Frauenklinikstrasse 10, Zuerich, CH-8091, Switzerland, - - 2015
Detection of delayed cerebral ischemia (DCI) in high-grade subarachnoid haemorrhage (SAH) is an unsolved issue. Conventional near-infrared spectroscopy (NIRS) with optodes applied over the skin is controversial because the NIRS signal is contaminated by extracerebral tissue. The objective is to quantify and subtract the contribution from extracerebral tissue from the ...
Valenta Ines I Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, - - 2015
Conventional myocardial perfusion scintigraphy with SPECT/CT or with PET/CT has been established as pivotal clinical imaging modality for the identification of hemodynamically obstructive coronary artery disease (CAD) and risk stratification of patients with suspected or known CAD. While the assessment of the relative distribution of radiotracer uptake in the left-ventricular ...
Füchtemeier Martina M 1] Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Berlin, - - 2014
Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and to test whether the renin-angiotensin system (RAS) can offer therapeutic benefit. For the first time, different patterns of cerebral blood flow alterations were observed in hypoperfused ...
Kamhieh-Milz J J Institute for Transfusion Medicine, Charité University Medical Centre, Berlin, - - 2014
The objective of this study was to elucidate whether complement activation occurs during the storage of RBCs in newly formulated PAGGS-M storage medium. The reason for red blood cell (RBC) storage lesions is not yet fully understood. The contribution of complement to RBC storage lesion has not been extensively characterised. ...
Laohakunakorn Nadanai - - 2014
We report observations of a striking reversal in the direction of electroosmotic flow (EOF) outside a conical glass nanopore as a function of salt concentration. At high ionic strengths we observe EOF in the expected direction as predicted by classical electrokinetic theory, while at low salt concentrations the direction of ...
Lautz Andrew J AJ Divisions of General Pediatrics, - - 2014
A 33-month-old girl presented with 3 days of fever and 1 day of multiple paroxysmal episodes of screaming with apparent unresponsiveness, flexed lower extremities, clenched hands, and upward eye deviation. These events lasted seconds to a minute at a time and occurred only during sleep. She slept peacefully between episodes ...
Wang Guanghuan G The Second Affiliated Hospital, Shantou University Medical College, Shantou City, 515041, Guangdong Province, People's Republic of - - 2014
The aim of this study is to explore the prognostic value of blood zinc, iron, and copper levels in critically ill neonates by comparing blood metal levels with the score for neonatal acute physiology (SNAP). Forty-six neonates (26 boys, 20 girls; ages ranging from 10 min to 23 days) who had been ...
Grasas A A Department of Economics and Business, Universitat Pompeu Fabra, Barcelona, - - 2014
Recent studies suggest that transfusion of old red blood cell (RBC)s, mainly those close to the 42-day maximum shelf life (MSL), is associated with increased morbi-mortality. Although there is no formal proof supporting a causal relationship, the precautionary principle asks for corrective interventions whenever they do not bring about other ...
Joo Nam-Seok NS , Suwon, Republic of Korea, - - 2014
Serum ferritin as well as blood mercury are reported to be associated with chronic inflammation. However, the relation between serum ferritin and blood mercury has not yet been established. We utilized the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-2012) 10,977 subjects (5433 males and 5544 females). To evaluate ...
Brouard D D Recherche et développement, Héma-Québec, Québec, QC, - - 2014
The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and a polymer-based hybridization optical transducer was designed. The objectives of ...
Guedes Marques Maria M Vascular Access Center, Nephrocare Coimbra, Coimbra, - - 2014
National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines recommend Doppler ultrasound (DU) for surveillance of vascular access (VA), but trials have not been unanimous about its benefit on VA patency. The aim of this study was to evaluate the accuracy of DU for patency, as well as ...
Mehmetoglu Idris I Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan - - 2014
In this study we have investigated oxidized low density lipoprotein (OxLDL) and ischemia-modified albumin (IMA) levels in cord blood and neonatal blood of aged 7 days neonates born to preeclamptic and normotensive healthy mothers. The study was performed on 30 neonates born to preeclamptic and 20 neonates born to normotensive ...
Good Christopher C a The Conservation Fund's Freshwater Institute, 1098 Turner Road , Shepherdstown , West Virginia 25443 , - - 2014
Abstract During a controlled 6-month study using six replicated water recirculation aquaculture systems (WRASs), it was observed that Rainbow Trout Oncorhynchus mykiss in all WRASs exhibited a higher-than-normal prevalence of side swimming (i.e., controlled, forward swimming but with misaligned orientation such that the fish's sagittal axis is approximately parallel to ...
Jia Shirong S Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, - - 2014
Progress has been made in a 12 year's systemic study on the rice transgene flow including (i) with experiments conducted at multiple locations and years using up to 21 pollen recipients, we have elucidated the patterns of transgene flow to different types of rice. The frequency to male sterile lines is ...
Daniels Sarah I SI Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California. - - 2014
Blood miRNAs are a new promising area of disease research, but variability in miRNA measurements may limit detection of true-positive findings. Here, we measured sources of miRNA variability and determine whether repeated measures can improve power to detect fold-change differences between comparison groups. Blood from healthy volunteers (N = 12) ...
Tey Siew Ling SL Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, 14 Medical Drive, #07-02, Singapore, 117599, - - 2014
Regular nut consumption is inversely associated with cardiovascular disease risk. No study has compared the effects of regular consumption of different types and forms of nuts on acceptance, which is a crucial determinant of long-term compliance to consume nuts regularly. This study examined the effects of different types and forms ...
Uyanik Metin M Gulhane School of Medicine, Department of Medical Biochemistry , Ankara , - - 2014
Background. Blood gas analyzers (BGAs) are important in assessing and monitoring critically ill patients. However, the random use of BGAs to measure blood gases, electrolytes and metabolites increases the variability in test results. Therefore, this study aimed to investigate the correlation of blood gas, electrolyte and metabolite results measured with ...
Debaty Guillaume G Department of Medicine-Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA; UJF-Grenoble 1/CNRS/CHU de Grenoble/TIMC-IMAG UMR 5525, Grenoble, France. Electronic address: - - 2014
Cerebral perfusion is compromised during cardiopulmonary resuscitation (CPR). We hypothesized that beneficial effects of gravity on the venous circulation during CPR performed in the head-up tilt (HUT) position would improve cerebral perfusion compared with supine or head-down tilt (HDT). Twenty-two pigs were sedated, intubated, anesthetized, paralyzed and placed on a ...
Irace Concetta C Department of Clinical and Experimental Medicine, Magna Græcia University, University Campus "Salvatore Venuta", Viale Europa, Località Germaneto, 88100, Catanzaro, - - 2014
Flow-mediated dilation (FMD) is a complex mechanism involving several mediators, and different hemodynamic forces. Temporally distinct FMD patterns can be elicited by ischemic stimulus. Some subjects dilate early after cuff release, while others dilate later or do not dilate at all. Aim of the present research was to verify if ...
Liao Hongzhu - - 2014
Three mixer designs, a back-flow tee mixer (BT), an end-blocked membrane tee mixer (EMT), and a tubular membrane mixer (TM) were fabricated and compared to three commercially available mixers, Visco-Jet Micro mixer (VJM), HS binary tee mixer with 2 and 10 L (HS-2 and HS-10) mixing cartridges. Internal volumes ranged ...
Herrling Maria P MP Chair of Water Chemistry and Water Technology, Karlsruhe Institute of Technology, Engler-Bunte-Ring 1, 76131, Karlsruhe, - - 2014
Biofilms on cylindrical carrier material originating from a lab-scale moving bed biofilm reactor (MBBR) were investigated by means of Magnetic Resonance Imaging (MRI). The aim of this study was to determine the local flow velocities at the inner face of the biofilm carrier. To get an insight into the mass ...
Mohapatra Rinkle R National Institute of ImmunoHematology, (Indian Council of Medical Research), KEM Hospital Campus, Parel, Mumbai, - - 2014
Diagnosis of hemoglobin disorders is based mostly on abnormal red blood cell indices, elevated levels of HbA2, HbF or any other Hb on the Variant HPLC system and confirmation by molecular methods. However, large scale population screening is of prime importance and requires a simple, accurate and cost effective technique. ...
Suzuki Toyofumi T Laboratory of Pharmaceutics, Nihon University School of Pharmacy, 7-7-1 Narashinodai, Funabashi, Chiba, 274-8555, - - 2014
The purpose of this study was to characterize the brain-to-blood efflux transport of amantadine across the blood-brain barrier (BBB). The apparent in vivo efflux rate constant for [(3) H]amantadine from the rat brain (keff ) was found to be 1.53 × 10(-2)  min(-1) after intracerebral microinjection using the Brain Efflux Index method. ...
Chung Hye Kyung HK Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul 120-749, Republic of - - 2014
This study aimed to examine whether blood levels of heavy metals, such as lead, mercury and cadmium, are related with pulmonary function in Korean adults. This investigation included 870 Korean adults (≥40 years) who received pulmonary function testing in the Korea National Health and Nutrition Examination Survey (KNHANES) V-2, 2011. ...
Fagerstedt Sara S The Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, - - 2014
Allergic diseases develop in genetically susceptible individuals in a complex interplay with the environment, usually early in life. We have previously shown that the anthroposophic lifestyle is associated with reduced risk of allergic disease in children, but details on the influencing environmental factors are largely unknown. This study aims to ...
Searles Nielsen Susan S University of Washington, Department of Environmental and Occupational Health Sciences, Box 357234, Seattle, WA 98195, USA; University of Washington, Department of Neurology, Box 359775, Seattle, WA 98195-9775, USA. Electronic address: - - 2014
Epidemiologic studies suggest that occupational exposure to pesticides might increase Parkinson disease risk. Some pesticides, such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of α-synuclein, a protein critically involved in Parkinson disease. Therefore, we assessed total blood cell α-synuclein in 90 specimens from 63 agricultural pesticide handlers, ...
Liu Xiuyun X Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, - - 2014
The impulse response (IR)-based autoregulation index (ARI) allows for continuous monitoring of cerebral autoregulation using spontaneous fluctuations of arterial blood pressure (ABP) and cerebral flow velocity (FV). We compared three methods of autoregulation assessment in 288 traumatic brain injury (TBI) patients managed in the Neurocritical Care Unit: (1) IR-based ARI; ...
Schwarz Janina C V JC Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Endothelial shear stress (ESS) dynamics are a major determinant of atherosclerosis development. The frequently used Poiseuille method to estimate ESS dynamics has important limitations. Therefore, we investigated whether Womersley flow may provide a better alternative for estimation of ESS while requiring equally simple hemodynamic parameters. Common carotid blood flow, centerline ...
Feng Lei L Key Laboratory of Forensic Genetics, Ministry of Public Security, Institute of Forensic Science, Beijing, 100038, - - 2014
To obtain single-source short tandem repeat (STR) profiles in trace female/male blood mixture samples, we combined florescence in situ hybridization (FISH), laser microdissection, and low volume PCR (LV-PCR) to isolate male/female cells and improve sensitivity. The results showed that isolation of as few as 10 leukocytes was sufficient to yield ...
Watt Andrew D AD The Florey Institute of Neuroscience and Mental Health, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia The Neuroproteomics Platform, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, VIC, - - 2014
Biomarkers enabling the preclinical identification of Alzheimer's disease (AD) remain one of the major unmet challenges in the field. The blood cellular fractions offer a viable alternative to current cerebrospinal fluid and neuroimaging modalities. The current study aimed to replicate our earlier reports of altered binding within the AD-affected blood ...
Salameh Aida A Clinic for Pediatric Cardiology, University of Leipzig, Heart Centre, Leipzig, Germany. Electronic address: - - 2014
Children with congenital heart disease are often operated at a very young age. Cardiopulmonary bypass (CPB) has become indispensable for these sometimes very complex operations, but one cannot neglect a possible negative impact of CPB on organ function. Traditionally, CPB was developed with non-pulsatile flow but there are clinical observations ...
Ito Akira A Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, - - 2014
Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with unknown etiology that is characterized by the development of abnormal vascular networks at the base of the brain. Recent genome-wide studies identified RNF213 as an important MMD susceptibility gene. However, the exact mechanism by which the RNF213 abnormality leads to ...
Sobczyk Olivia O Institute of Medical Science, University of Toronto, Toronto, Ontario, - - 2014
Attribution of vascular pathophysiology to reductions in cerebrovascular reactivity (CVR) is confounded by subjective assessment and the normal variation between anatomic regions. This study aimed to develop an objective scoring assessment of abnormality. CVR was measured as the ratio of the blood-oxygen-level-dependent magnetic resonance signal response divided by an increase ...
Gunier Robert - - 2014
Manganese (Mn) is an essential nutrient but at high exposure levels is a neurotoxicant. There is no well-validated biomarker to assess perinatal Mn exposure. A total of 75 mother-child pairs provided blood, urine, and/or deciduous tooth samples. We analyzed Mn in dentin and enamel of shed teeth; maternal, cord, and ...
Chiu Chih-Yung CY Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Centre, Chang Gung Memorial Hospital, Keelung, Taiwan; Division of Pediatric Pulmonology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, - - 2014
The association between vitamin D status at birth and allergen sensitizations is uncertain. The aim of this study was to investigate the relationship of cord blood vitamin D status with allergen sensitizations and the development of atopic diseases in early childhood. Children aged 0 through 4 years from a birth ...
Shiga Yukihiro Y Department of Ophthalmology, Tohoku University Graduate School of Medicine , Miyagi , Japan - - 2014
Abstract Purpose: To evaluate laser speckle flowgraphy (LSFG) measurements of the optic nerve head (ONH) blood flow (BF) response to hyperoxia. Methods: This prospective study included 30 eyes of 30 healthy volunteers (mean age: 28.5 ± 4.0, male:female = 13:17). The testing protocol had three phases: in the baseline phase, subjects breathed room air; ...
Chang Jeonghyun J Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of - - 2014
The BACTEC™ FX (BD, USA) has been recently upgraded to measure virtual blood volume (VV) in batches of 25 PLUS Aerobic/F bottles. VVs were compared with manually measured actual volumes (AVs). The mean AV was larger in anaerobic bottles: 2.6±1.9mL in 2995 Aerobic/F bottles and 3.3±1.8mL in 3053 Lytic/10 Anaerobic/F ...
Jiang Fang-Zhen FZ Department of Plastic and Reconstructive Surgery, Second Affiliated Hospital, Zhejiang University, School of Medicine, No. 88 Jiefang road, Hangzhou, 310009, - - 2014
A tourniquet is commonly used in total knee arthroplasty (TKA). However, the effectiveness and safety of tourniquets are debated. We performed this study to investigate whether patients benefit from the use of tourniquets in TKA. The literature search was conducted using PubMed, Cochrane Library, MEDLINE, Embase, and other medical databases. ...
Fernandez-Flores Angel A Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, - - 2014
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B- and T-lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors ...
Christensen R D RD 1] The Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, UT, USA [2] Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA [3] Division of Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, - - 2014
Objective:Neonates with undiagnosed hereditary spherocytosis (HS) are at risk for developing hazardous hyperbilirubinemia and anemia. Making an early diagnosis of HS in a neonate can prompt anticipatory guidance to prevent these adverse outcomes. A recent comparison study showed that a relatively new diagnostic test for HS, eosin-5-maleimide (EMA)-flow cytometry, performs ...
Zanderigo Francesca F Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Columbia University, New York, New York, - - 2014
Full quantification of a positron emission tomography (PET) radioligand binding to its target is preferred because it requires the fewest assumptions, but generally involves measuring the concentration of free radioligand in the arterial plasma by collecting blood samples from the subject's radial artery during the scan, and performing metabolite analysis. ...
Shivaprasad Ks K Department of Endocrinology & Metabolism, Institute of Post-Graduate Medical Education & Research (IPGMER) and Seth Sukhlal Karnani Memorial (SSKM) Hospital, 244 AJC Bose Road, Calcutta-700020, - - 2014
Objective: Cardiovascular events are the commonest cause of mortality in Cushing's syndrome (CS). This study aimed to evaluate the impact of novel factors on atherosclerosis in endogenous CS.Methods: Twenty-two female patients with CS and 33 normal female controls underwent evaluation of fibrinogen, high sensitivity c-reactive protein (hsCRP), inflammatory cytokines [interleukin ...
Gong Ping P Center for Dyslipidemia and Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 BeiLiShi Road, XiCheng District, Beijing 100037, China; Department of Cardiology, The Fifth Hospital of Wuhan & Affiliated Guangci Hospital of Wuhan University, Wuhan 430050, - - 2014
Objective: Although the study on the relationship between ABO blood groups and coronary atherosclerosis has a long history, few data is available regarding ABO to severity of coronary atherosclerosis in a large cohort study. Therefore, the present study aimed to investigate the relation of the ABO blood groups to the ...
Hara Manabu M Department of Orthopaedic Surgery, Toho University School of Medicine, Tokyo, - - 2014
The aim of this study was to investigate whether differences in the methods of approach to the vertebral arch influence the invasiveness of conventional discectomy and microendoscopic discectomy (MED). In this study, 41 Wistar rats were divided into four groups: controls (no surgery) (n = 10), shams (skin incision only) (n = 11), MED ...
Reichert Christof C Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, - - 2014
Objective-To evaluate the use of a micro-lightguide tissue spectrophotometer for measurement of tissue oxygenation and blood flow in the small and large intestines of horses under anesthesia. Animals-13 adult horses without gastrointestinal disease. Procedures-Horses were anesthetized and placed in dorsal recumbency. Ventral midline laparotomy was performed. Intestinal segments were exteriorized ...
Cândido Thaísa D TD Departments of Anesthesiology, São Paulo State University, Botucatu, SP, 18618-970, - - 2014
Objective-To evaluate the effects of a dexmedetomidine constant rate infusion (CRI) and atropine on changes in global perfusion variables induced by hemorrhage and volume replacement (VR) in isoflurane-anesthetized dogs. Animals-8 adult dogs. Procedures-Each dog was anesthetized twice, with a 2-week interval between anesthetic sessions. Anesthesia was maintained with 1.3 times ...
Grubb Tamara L TL Department of Animal Environment and Health, Swedish University of Agricultural Sciences, 53223 Skara, Sweden., Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA - - 2014
Objective-To image the spatial distribution of pulmonary blood flow by means of scintigraphy, evaluate ventilation-perfusion (VA/Q) matching and pulmonary blood shunting (Qs/Qt) by means of the multiple inert gas elimination technique (MIGET), and measure arterial oxygenation and plasma endothelin-1 concentrations before, during, and after pulse-delivered inhaled nitric oxide (PiNO) administration ...
Jung Hwa Sung HS Department of Anesthesiology and Pain Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, - - 2014
The impact of volatile induction using large-dose sevoflurane (VI-S) on cerebral blood flow has not been well investigated. The present study compared the changes in cerebral blood flow of middle cerebral artery using transcranial Doppler (TCD) during VI-S and conventional induction using propofol. Patients undergoing elective lumbar discectomy were randomly ...
Barco Sebastiano S Clinical Pathology Laboratory Unit, Istituto Giannina Gaslini, Genoa, - - 2014
Background Therapeutic drug monitoring (TDM) of antibiotics in children is of fundamental importance for effective patient management. The use of dried blood spot (DBS) offers a number of advantages over conventional blood collection. The aim of this study is to develop and validate a method to measure piperacillin/tazobactam in DBS. ...
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