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Bolton-Maggs Paula H B PH Serious Hazards of Transfusion UK National Haemovigilance Scheme, Manchester Blood Centre and the University of Manchester, Manchester, - - 2014
'Wrong blood in tube' (WBIT) errors, where the blood in the tube is not that of the patient identified on the label, may lead to catastrophic outcomes, such as death from ABO-incompatible red cell transfusion. Transfusion is a multistep, multidisciplinary process in which the human error rate has remained unchanged ...
Rassi Andrew N AN aCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts bDivision of Cardiology, University of California, Irvine Medical Center, Orange, California, - - 2014
In an era of increased scrutiny of the appropriateness and safety of revascularization, interventional cardiologists must evolve by adding key tools to their armamentarium. This review highlights the utility of optical coherence tomography and fractional flow reserve in the catheterization lab and provides a practical guide for using these technologies ...
Hibbs S P SP Oxford University Clinical Academic Graduate School, University of Oxford; Blood Safety and Conservation Team, Oxford University Hospitals (OUH) NHS - - 2014
To assess the impact on transfusion practice of a two-stage electronic intervention: the introduction of a decision support system (DSS) followed by the addition of electronic remote blood issue (ERBI). With increasing evidence to show the benefit of restrictive transfusion policies, it is important to ascertain which interventions can increase ...
Broderick Barry J BJ Electrical & Electronic Engineering, School of Engineering & Informatics, NUI Galway, University Road, Galway, Ireland. National Centre for Biomedical Engineering Science, NUI Galway, University Road, Galway, - - 2014
Deep Vein Thrombosis (DVT) is a life threatening condition and a serious concern among hospitalised patients, with death occurring in approximately 6% of cases. Intermittent pneumatic compression (IPC) is commonly used for DVT prevention, however suffers from low compliance and issues of usability and portability. Neuromuscular electrical stimulation (NMES) has ...
Stramer S L SL American Red Cross Gaithersburg, MD, - - 2014
In August 2009, a group from the AABB (Stramer et al., Transfusion 2009;99:1S-29S, Emerging Infectious Disease Agents and their Potential Threat to Transfusion Safety; http://www.aabb.org/resources/bct/eid/Pages/default.aspx) published a Supplement to Transfusion that reviewed emerging infectious disease (EID) agents that pose a real or theoretical threat to transfusion safety, but for which ...
Smirl Jonathan David JD 1University of British Columbia, Okanagan - - 2014
We examined the hypothesis that changes in the cerebrovascular resistance index (CVRi), independent of blood pressure (BP), will influence the dynamic relationship between blood pressure and cerebral blood flow in humans. We altered CVRi with (via controlled hyperventilation) and without (via Indomethacin (INDO; 1.2 mg/kg) changes in PaCO2. Sixteen subjects ...
Meel-van den Abeelen Aisha S S AS Radboud University Medical Center, Hemodynamic Lab at the Department of Geriatric Medicine, and Radboud Alzheimer Center, The - - 2014
Cerebral autoregulation (CA) is a key mechanism to protect the brain against excessive fluctuations in blood pressure (BP) and maintain cerebral blood flow. Analyzing the relationship between spontaneous BP and cerebral blood flow velocity (CBFV) using transfer function analysis is a widely used technique to quantify CA in a non-invasive ...
Kuznetsova Daria V DV Department of Pathophysiology, Altai State Medical University, Barnaul, - - 2014
Arterial partial pressure alteration of CO2 ((Equation is included in full-text article.)) affects not only the cerebral blood flow velocity but also the systemic arterial blood pressure (BP). At the same time, BP can affect the cerebral blood flow. The objective of the present research is to study the impact ...
Phillips Aaron A AA 1] Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada [2] Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada [3] Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, British Columbia, Canada [4] International Collaboration on Repair Discoveries (ICORD), Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, and GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, - - 2014
Individuals with high-level spinal cord injury (SCI) experience low blood pressure (BP) and cognitive impairments. Such dysfunction may be mediated in part by impaired neurovascular coupling (NVC) (i.e., cerebral blood flow responses to neurologic demand). Ten individuals with SCI >T6 spinal segment, and 10 age- and sex-matched controls were assessed ...
Chiquet Christophe C Department of Ophthalmology, CHU Grenoble, University Hospital, Grenoble, 38043, - - 2013
Purpose: This study investigates the effect of increased ocular perfusion pressure (OPP), on optic nerve head (ONH) hemodynamics. Methods: In 21 healthy subjects, the increase in arterial blood pressure (BP), measured continuously using a pneumatic transcutaneous sensor Nexfin™, was produced by isometric exercise consisting of 2 minutes of handgripping. ONH ...
Panerai Ronney B - - 2013
Dynamic cerebral autoregulation (dCA), the transient response of cerebral blood flow (CBF) to rapid changes in arterial blood pressure (BP), is usually quantified by parameters extracted from time- or frequency-domain analysis. Reproducibility studies of dCA parameters and consideration of the physiological determinants of the dynamic BP-CBF relationship provide strong indications ...
Varotti G - - 2013
Liver transplantation (OLT) can entail a high risk of blood loss requiring transfusions, which increase morbidity and mortality. In recent years many efforts have been spent to improve the surgical and anesthetic management to decrease transfusion rates during OLT. Preoperative predictors for transfusion in OLT, remain uncertain. We retrospectively reviewed ...
Shah Dharmesh - - 2013
Background:Significant hemodynamic changes occur immediately after birth in preterm infants. Amplitude-integrated electroencephalography (aEEG) provides a method of assessing brain activity in sick neonates; however, the relationship between systemic blood flow, blood pressure (BP) and aEEG is not clear.Methods:Quantitative measures of aEEG continuity and amplitude were correlated with superior vena cava ...
Maggio Paola P Neurologia Clinica, Università Campus Bio-Medico, Rome, - - 2013
Neurovascular coupling (NVC) and dynamic cerebral autoregulation (dCA) are both impaired in the acute phase of ischemic stroke, but their reciprocal interactions are difficult to predict. To clarify these aspects, the present study explored NVC in a healthy volunteer population during a surrogate state of impaired dCA induced by hypercapnia. ...
Gould Bronwen - - 2013
Treatment of acute hypertension after intracerebral hemorrhage (ICH) is controversial. In the context of disrupted cerebral autoregulation, blood pressure (BP) reduction may cause decreased cerebral blood flow (CBF). We used serial computed tomography perfusion to test the hypothesis that CBF remains stable after BP reduction. Patients recruited within 72 hours ...
Zhang Wei-Bo - - 2013
To verify the ancient theory of rather missing the acupoint than missing the meridian, acupuncture at nonacupoint on meridian and acupuncture at nonacupoint off meridian were performed, respectively. The blood perfusion (BP) on the calf around bladder meridian area was measured with a laser Doppler perfusion imager before, during, and ...
Rodell Anders A Department of Nuclear Medicine and PET Centre, Aarhus University Hospital Aarhus, - - 2013
Rapid clearance and disappearance of a tracer from the circulation challenges the determination of the tracer's binding potentials in brain (BP ND) by positron emission tomography (PET). This is the case for the analysis of the binding of radiolabeled [(11)C]Pittsburgh Compound B ([(11)C]PIB) to amyloid-β (Aβ) plaques in brain of ...
Lyngeraa T S - - 2012
Running induces characteristic fluctuations in blood pressure (BP) of unknown consequence for organ blood flow. We hypothesized that running-induced BP oscillations are transferred to the cerebral vasculature. In 15 healthy volunteers, transcranial Doppler-determined middle cerebral artery (MCA) blood flow velocity, photoplethysmographic finger BP, and step frequency were measured continuously during ...
Parlakgumus Huriye A - - 2012
PURPOSE: To investigate if normotensive and hypertensive patients with intrauterine growth restricted (IUGR) fetuses were different with respect to maternal and fetal characteristics and Doppler flow. METHODS: The records of patients with IUGR fetuses who had to be delivered before 34th gestational week because of fetal distress were examined. Early ...
Lee Jimmy - - 2012
Blood-based transcriptomic signature in psychosis is an alternative to a brain-based signature. In this study, we profiled whole-blood RNA from 26 patients with first-episode psychosis, and 26 matching controls. We identified a 400-gene signature that classified patients from controls accurately and tested the robustness using other modelling methods.
Pernot Pierre - - 2012
d-Serine is a co-agonist of N-methyl-d-aspartate (NMDA) receptors. It has been implicated in the etiology of schizophrenia and has shown efficacy as an adjuvant to reduce positive and negative symptoms of schizophrenia. In addition, d-serine can modulate cognition in animals when administered alone. However, the neurochemical effects of exogenous d-serine ...
Gallego Juan A JA The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA. - - 2012
Alterations in microRNA (miRNA) expression in postmortem brain tissue or peripheral blood have been linked to schizophrenia. Cerebrospinal fluid might provide an in vivo biomarker more directly reflecting functional changes in the brain. The goals of this study were to determine the feasibility of detecting miRNAs in cerebrospinal fluid and ...
Hassan Gedaa - - 2012
Obstructive Sleep Apnea (OSA) is one of the most common breathing disorder, affecting approximately 27% of U.S. adults. Limited data have suggested that OSA causes cerebral autoregulation impairment, thus being an important risk factor to stroke. The objective of this paper is to investigate and measure the relation between arterial ...
Jungmann L - - 2011
An 88-year-old woman committed suicide by drinking a toxic amount of highly concentrated alcohol and setting two rooms of her flat on fire. As there was not enough oxygen, the fire went out, however. At autopsy, no thermal lesions were found on the body, but soot depositions in the airways ...
Logtenberg Hella - - 2011
An approach to control two-phase flow systems in a poly(dimethylsiloxane) (PDMS) microfluidic device using spatially selective surface modification is demonstrated. Side-by-side flows of ethanol : water solutions containing different polymers are used to selectively modify both sides of a channel by laminar flow patterning. Introduction of air pockets during modification allows for ...
Istaphanous George K - - 2011
To review the pathophysiology of anemia, as well as transfusion-related complications and indications for red blood cell (RBC) transfusion, in critically ill children. Although allogeneic blood has become increasingly safer from infectious agents, mounting evidence indicates that RBC transfusions are associated with complications and unfavorable outcomes. As a result, there ...
Ridder Trent D - - 2011
Previous works investigated a spectroscopic technique that offered a promising alternative to blood and breath assays for determining in vivo alcohol concentration. Although these prior works measured the dorsal forearm, we report the results of a 26-subject clinical study designed to evaluate the spectroscopic technique at a finger measurement site ...
Cohen Jonathan - - 2011
The aim of the study was to document transfusion practices in a cross section of general intensive care units (ICUs) in Israel and to determine whether current guidelines are being applied. This prospective study was performed in 5 general ICUs in Israel over a 3-month period. Red cell transfusion data ...
Kajja I - - 2011
Aim: This study aimed at establishing the clinical utility of the surgical blood order equation (SBOE) in patients undergoing femoral fracture surgery. Background: A blood ordering schedule defines the perioperative blood use in elective surgery. It lists the number of units of blood required for each procedure preoperatively. Materials and ...
Noordin Shahryar - - 2011
Revision THA is associated with high blood loss and a high probability of blood transfusion in the perioperative period. In November 2003, government legislation established the Blood Utilization Program at our center to reduce the rate and risks associated with allogenic transfusion. The purposes of this study were to (1) ...
Hirose Takahisa - - 2011
To examine whether hand contamination with fruit results in a false blood glucose (BG) reading using capillary fingertip blood sample. The study subjects were healthy volunteers with normal glucose tolerance test. Capillary BG samples were collected from the fingertip after peeling orange, grape, or kiwi fruit, followed by no action, ...
Bosch M Alba - - 2011
Epidemiologic information on blood component usage can help improve the utilization of transfusion resources. Crosssectional survey in 2007 that included every hospital in Catalonia. Clinical data of blood recipients, including the four-digit International Classification of Diseases, 9th Revision, Clinical Modification codes and the indication for transfusion, were prospectively collected according ...
van Straten Albert H M - - 2011
Recently, concern has been expressed about the transfusion of older red blood cells after cardiac surgery. We tested the hypothesis that longer storage of transfused red blood cells increases the risk of early and late mortality in patients who undergo coronary artery bypass grafting. We retrospectively analyzed data of patients ...
Hassan Monique - - 2011
Allogeneic packed red blood cells (PRBCs) suppress immunity and influence outcomes. The influence of blood on the risk of infection and death may be related to the duration of storage. We sought to determine whether blood storage duration was associated with infection or death in a large cohort of injury ...
Jobes David D Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. - - 2011
The hemostatic property of "fresh" whole blood (WB) has been observed in military application and cardiac surgery and is associated with reduced blood loss, transfusion requirements, and donor exposures. The time from donation to transfusion defining "fresh" has not been systematically studied. We undertook an in vitro study of coagulation ...
McQuilten Zoe K - - 2011
Hospital transfusion laboratories collect information regarding blood transfusion and some registries gather clinical outcomes data without transfusion information, providing an opportunity to integrate these two sources to explore effects of transfusion on clinical outcomes. However, the use of laboratory information system (LIS) data for this purpose has not been validated ...
Mahadevan Devendra - - 2011
Effective utilisation of blood products is fundamental. The introduction of maximum surgical blood ordering schedules (MSBOS) for operations has been shown to improve transfusion services. A retrospective analysis was undertaken to establish an evidence-based MSBOS for revision total hip replacement (THR) and total knee revision (TKR). The impact of this ...
Lima Lúcio Flávio Peixoto de - - 2011
Thiamine deficiency has been associated with poorer clinical outcomes. Early recognition of thiamine deficiency is difficult in critically ill patients because clinical signs are nonspecific. We determined the prevalence of and identified risk factors associated with low blood thiamine concentrations upon admission of children to a pediatric intensive care unit ...
Girdauskas Evaldas - - 2010
OBJECTIVE: Aortic surgical procedures requiring hypothermic circulatory arrest are associated with altered hemostasis and increased bleeding. In a randomized clinical trial, we evaluated effects of thromboelastometrically guided algorithm on transfusion requirements. METHODS: Fifty-six consecutive patients (25 with acute type A dissection) undergoing aortic surgery with hypothermic circulatory arrest were enrolled ...
Welck Matthew - - 2010
James Blundell was an obstetrician, surgeon, physiologist and teacher. He is best known as the first to perform a successful human-to-human blood transfusion. However, he can also be accredited for significant advances in surgery and obstetrics. After a distinguished career at The United Hospitals of St Thomas and Guy's, he ...
Natukunda Bernard - - 2010
Red blood cell (RBC) alloimmunization occurs when individuals are exposed to erythrocytes that express blood group antigens different from their own. Consequences of alloimmunization include hemolytic disease of the fetus and newborn and hemolytic transfusion reactions, with potentially serious morbidity and mortality. Patients who formed antibodies showed a four to ...
Milligan C - - 2011
Uncontrolled haemorrhage is the leading cause of potentially reversible early in-hospital death following trauma. Approximately 25% of trauma patients arriving in the emergency department have evidence of early coagulopathy. It is vital that staff within the emergency department understand the basic pathophysiological consequences of massive blood loss in trauma and ...
Elfenbein J R - - 2010
Hepatic failure is one of the more common complications in foals requiring blood transfusion to treat neonatal isoerythrolysis. Iron intoxication is likely the cause of hepatic injury. To determine the effects of deferoxamine on iron elimination in normal foals. Thirteen neonatal foals. Randomized-controlled trial. At 1-3 days of age, foals ...
Kajja I - - 2010
To identify where and why delays occur in Uganda blood banks. The timely provision and supply of safe and efficacious blood components to hospitals depends on sound systems in the processing blood banks. Poorly managed systems lead to apparent blood shortages in hospitals and increase discard rates due to expiry ...
Fontaine Magali J - - 2010
Evolving concerns about storage lesions for red blood cells (RBCs) have led to ongoing trials evaluating the benefits of transfusing fresher blood to acutely ill patients. We evaluated several RBC maximum shelf lives (MSLs) and their impact on RBC availability and outdate rate. First, we determined the mean age of ...
Cannon-Diehl M Roseann - - 2010
Anemia and red blood cell (RBC) transfusions are common in critically ill and injured, trauma, and surgical patients. Tolerance of anemia is highly variable, depending on the presence of cardiovascular and other comorbid diseases that may diminish the hemodynamic response to a lower hemoglobin (Hb) level. The quest to define ...
Vuille-Lessard Elise - - 2010
The indications for red blood cell (RBC) transfusions remain unclear despite published guidelines. Our hypothesis was that the transfusion practice varies inside the Centre hospitalier de l'Université de Montréal (CHUM). A total of 701 charts of patients who underwent a knee or hip arthroplasty or prosthesis revision in three hospitals ...
Ellis Harold - - 2010
I think it is true to say that most of us in healthcare regard blood transfusion as just a routine, although very important, part of the care of patients undergoing major surgery. Yet behind that container of blood dripping into your patient lies a long and fascinating story of the ...
Santiago Mônica Deolindo - - 2010
Severe anaemic foetuses of Rhesus (Rh) isoimmunised mothers are usually treated by intrauterine transfusion (IUT). It is helpful to determine the volume of blood necessary to raise the concentration of haemoglobin by 1.0 g/dL in response to intrauterine transfusions. In this cross-sectional, observational study we evaluated 107 first IUT for ...
Elena Chiara - - 2011
Risk stratification in primary myelofibrosis is currently based on two international prognostic scoring systems, neither of which takes into consideration red blood cell transfusion-dependency. In 288 consecutive patients with primary myelofibrosis, red blood cell transfusion-dependency at diagnosis affects survival independently of the International Prognostic Scoring System (P < 0.001). To ...
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