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Amin-Hanjani Sepideh S Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois, - - 2014
Measurement of volume flow rates in major cerebral vessels can be used to evaluate the hemodynamic effects of cerebrovascular disease. However, both age and vascular anatomy can affect flow rates independent of disease. We prospectively evaluated 325 healthy adult volunteers using phase contrast quantitative magnetic resonance angiography to characterize these ...
Ponnusamy Karthikeyan E KE c/o Elaine P. Henze, BJ, ELS, Medical Editor and Director, Editorial Services, Department of Orthopaedic Surgery, The Johns Hopkins University/Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, #A665, Baltimore, MD 21224-2780. E-mail address: - - 2014
➤ Blood transfusion after orthopaedic surgery accounts for 10% of all packed red blood-cell transfusions, but use varies substantially across hospitals and surgeons.➤ Transfusions can cause systemic complications, including allergic reactions, transfusion-related acute lung injury, transfusion-associated circulatory overload, graft-versus-host disease, and infections.➤ Tranexamic acid is a new cost-effective blood management ...
Laflam Andrew A From the Departments of *Anesthesiology & Critical Care Medicine, ‖Pediatrics, ¶Neurology, and #Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; †Department of Anesthesiology, Tuft University School of Medicine, Boston, Massachusetts; ‡Texas Children's Hospital, Baylor College of Medicine, Houston, Texas; and §The Johns Hopkins Bloomburg School of Public Health, Baltimore, - - 2014
Although controversial, failing to consider the gravitational effects of head elevation on cerebral perfusion is speculated to increase susceptibility to rare, but devastating, neurologic complications after shoulder surgery in the beach chair position (BCP). We hypothesized that patients in the BCP have diminished cerebral blood flow autoregulation than those who ...
Malmberg L Pekka LP 1 Department of Allergy, Helsinki University Central Hospital , Helsinki, Finland - - 2014
Abstract Background: The Easyhaler(®) (EH) device-metered dry powder inhaler containing budesonide and formoterol is being developed for asthma and chronic obstructive pulmonary disease (COPD). As a part of product optimization, a series of in vitro and in vivo studies on flow rate dependency were carried out. Methods: Inspiratory flow parameters ...
Oh Chang-Mo CM Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea; The Korea Central Cancer Registry, National Cancer Center, Goyang, Republic of - - 2014
Cadmium exposure was found to cause a decline in lung function among the general population, but these findings were limited to smokers and gender differences were not explored. To examine the relationship between cadmium and chronic obstructive pulmonary disease (COPD) according to gender and smoking status in Korea. Cross-sectional data ...
Hough Judith L JL 1Paediatric Critical Care Research Group, Paediatric Intensive Care Unit, Mater Children's Hospital, South Brisbane, QLD, Australia. 2School of Physiotherapy, Australian Catholic University, Banyo, QLD, Australia. 3Critical Care of the Newborn Program, Mater Research, South Brisbane, QLD, - - 2014
To assess the effect of delivering high-flow nasal cannula flow on end-expiratory lung volume, continuous distending pressure, and regional ventilation distribution in infants less than 12 months old with bronchiolitis. Prospective observational clinical study. Nineteen bed medical and surgical PICU. Thirteen infants with bronchiolitis on high-flow nasal therapy. The study ...
Farkas Nelli N Institute of Bioanalysis, Institute of Family Medicine, Department of Rheumatology and Immunology, University of Pécs, Pécs and Third Department of Internal Medicine, Semmelweis University, Research Laboratory, Budapest, - - 2014
Objective. Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as ...
Piirilä Päivi L - - 2014
Dynamic gas compression during forced expiration has an influence on conventional flow-volume spirometry results. The extent of gas compression in different pulmonary disorders remains obscure. Utilizing a flow plethysmograph we determined the difference between thoracic and mouth flows during forced expiration as an indication of thoracic gas compression in subjects ...
Akinbami Babatunde O BO Department of Oral and Maxillofacial Surgery, University of Port Harcourt Teaching Hospital, Choba, PMB 6173 Port Harcourt, 500004 Rivers State, - - 2014
Background. Reports on estimated amount of blood loss in maxillofacial surgical procedures will guide clinicians through units of blood required for each procedure. The aim of the study was to assess the amount of blood loss and duration of surgery. Methods. All cases of maxillofacial surgical procedures done under GA ...
Espinosa Aurora A Department of Immunology and Transfusion Medicine, St. Olav University Hospital, Trondheim, - - 2014
Bleeding complications in cardiac surgery may lead to increased morbidity and mortality. Traditional blood coagulation tests are not always suitable to detect rapid changes in the patient's coagulation status. Point-of-care instruments such as the TEG (thromboelastograph) and RoTEM (thromboelastometer) have been shown to be useful as a guide for the ...
Pisano A A Cardiac Anesthesia and Intensive Care Unit, "Monaldi" Hospital A.O.R.N. "Dei Colli", Naples, - - 2014
Several near-infrared spectroscopy oximeters are commercially available for clinical use, with lack of standardization among them. Accordingly, cerebral oxygen saturation thresholds for hypoxia/ischemia identified in studies conducted with INVOS(TM) models do not necessarily apply to other devices. In this study, the measurements made with both INVOS(TM) and EQUANOX(TM) oximeters on ...
Ko Hsin-Kuo HK Institutes of Physiology, National Yang-Ming University, Taipei, Taiwan; Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, - - 2013
High-mobility group box 1 (HMGB1) is an important mediator in multiple pathological conditions, but the expression of HMGB1 in chronic obstructive pulmonary disease (COPD) has not yet been completely investigated. We aimed to analyze the relationship between HMGB1 expression in blood and lung tissue and the development of COPD. Twenty-eight ...
Matsubara Keisuke - - 2013
O-methyl metabolite (L-[β-(11)C]OMD) of (11)C-labeled L-3,4-dihydroxyphenylalanine (L-[β-(11)C]DOPA) can penetrate into brain tissue through the blood-brain barrier, and can complicate the estimation of dopamine synthesis capacity by positron emission tomography (PET) study with L-[β-(11)C]DOPA. We evaluated the impact of L-[β-(11)C]OMD on the estimation of the dopamine synthesis capacity in a human ...
Quanjer Philip H - - 2013
To determine the added value of measuring the forced mid-expiratory flow (FEF25-75%) and flow when 75% of the forced vital capacity (FVC) has been exhaled (FEF75%) over and above the measurement of the forced expiratory volume in one second (FEV1), FVC and FEV1/FVC ratio.Spirometric records with FEV1, FVC and FEF25-75% ...
Koch Ulrike - - 2013
Evaluation of micromilieu-dependent quantified γH2AX foci as a potential predictive biomarker in well-oxygenated tumour areas in 9 HNSCC xenograft models in vivo. GammaH2AX foci were quantified in perfused tumour areas 30min (initial γH2AX foci) and 24h (residual γH2AX foci) after exposure to a single dose of 4Gy. The initial and ...
Urushikubo Akira - - 2013
Airflow in an avian respiratory system was simulated to study why birds affected with airsacculitis have respiratory distress. The airflow in the avian lung was modeled with a 1D electrical circuit and simulated for investigating what effect an increase in wall thickness of air sacs caused by airsacculitis has on ...
Raposo Liliana Bárbara Perestrelo de Andrade e LB Northern Lisbon Hospital Center, Department of Pulmonology, Lisbon, - - 2013
To assess the sensitivity and specificity of flow-volume curves in detecting central airway obstruction (CAO), and to determine whether their quantitative and qualitative criteria are associated with the location, type and degree of obstruction. Over a four-month period, we consecutively evaluated patients with bronchoscopy indicated. Over a one-week period, all ...
Fleck Robert R Department of Pediatric Radiology, Cincinnati Children's Hospital - MLC 5031, 3333 Burnett Avenue, Cincinnati, OH, 45229, USA, - - 2013
Cystic fibrosis (CF) is a common genetic disease in Caucasians. Chronic pulmonary disease with progressive destruction of the pulmonary parenchyma is two of the major morbidities, but the relationship between clinical severity of CF and aortopulmonary collateral blood flow has not been assessed. The purpose of this study is to ...
Martí Joan Daniel - - 2013
We investigated the effects of two different types of manual rib cage compression on expiratory flow and mucus clearance during prolonged mechanical ventilation in pigs. Prospective randomized animal study. Animal research facility, University of Barcelona, Spain. Nine healthy pigs. Pigs were tracheally intubated, sedated, paralyzed, and mechanically ventilated. The animals ...
Seppä Ville-Pekka - - 2013
Abstract Impedance pneumography (IP) is a non-invasive respiration measurement technique. Emerging applications of IP in respiratory medicine use the measured signal to monitor pulmonary flow and volume parameters related to airway obstruction during tidal breathing (TB). This requires a high impedance change (ΔZ)-to-lung volume change (ΔV) linearity. Four potential electrode ...
Woyceichoski Iverson Ernani Cogo - - 2013
Aim:  Crack cocaine is the freebase form of cocaine that can be smoked. The use of this drug has been considered a public health problem in many countries. The aim of this study was to assess the stimulated salivary flow rate (SSFR), pH, and the buffer capacity of saliva in ...
Caspersen Cecilie - - 2013
Pulmonary oxygen toxicity is associated with inflammatory responses in the airways and alveoli. The purpose of this study was to investigate whether the changes in exhaled nitric oxide (FE(NO)) after exposure to normobaric hyperoxia (NBO), 100% oxygen (O2) at 1 atmosphere absolute (atm abs) for 90 minutes, are associated with ...
Kafshgari Fatemeh - - 2013
Molybdenum (VI) biosorption process was investigated by marine algae Cystoseria indica pretreated with 0.1 M CaCl2 solution in a packed bed column. The biosorbent was characterized by FTIR, BET and SEM analyses. The results showed that Mo (VI) ions should be chelated with the hydroxyl, carboxyl and amine groups of ...
Hegland Karen W - - 2013
Cough effectiveness is determined by a combination of volume of air expired and maximum expiratory airflow rate. Studies of cough sensitivity identify cough thresholds based on at least 2 or 5-cough re-accelerations to a stimulus, however, to date no study has examined the interplay between the distribution of cough expired ...
Dube Kamalesh J - - 2013
Dust generated during the handling and processing of cotton causes ill health of ginning workers. The purpose of this study was to determine the prevalence of respiratory symptoms among cotton-ginning workers. This study involved 188 workers of 10 cotton-ginning factories. Forced vital capacity (FVC), peak expiratory flow rate (PEFR), and ...
Moran Peter M - - 2012
We aimed to determine if providers could detect simulated spontaneous respirations of an intubated neonate by palpating gas flow changes at the positive end expiratory pressure valve of a T-piece resuscitation device in an in vitro setting. We also aimed to demonstrate whether the sensitivity of this methodology was related ...
Danzer Enrico - - 2012
Infants with giant omphalocele (GO) are at increased risk for persistent respiratory insufficiency, yet information regarding the systematic assessment of their lung function is limited. We performed a group of pulmonary function tests (PFTs) including spirometry, fractional lung volume measurements, assessment of bronchodilator responsiveness, and passive respiratory mechanics in GO ...
Mihara Makoto - - 2012
In healthy people, no retrograde lymph flow occurs because of valves in collecting lymph vessels. However, in secondary lymphedema after lymph node dissection, lymph retention and lymphatic hypertension occurs and valvular dysfunction induces retrograde lymph flow. In this case reported, we focused on retrograde lymph flow and performed retrograde lymphatico-venous ...
Van de Wiele Christophe - - 2012
Available literature on the differences in circulation and microcirculation of normal liver and liver metastases as well as in rheology of the different radiolabelled microspheres [(99m)Tc-labelled macroaggregates of albumin (MAA), (90)Y-TheraSpheres and (90)Y-SIR-spheres] used in selective internal radiation therapy (SIRT) are reviewed and implications thereof on the practice of SIRT ...
Montheard Julie - - 2012
Quantification of different physiological states of Candida shehatae cells was performed by flow cytometry associated with two fluorescent probes. Propidium iodide and carboxyfluorescein diacetate acetoxymethyl ester fluorescent dyes were chosen based on data from the literature. A staining procedure, developed from the previous works was applied to the yeast. Then, ...
Zettergren Eric - - 2012
Sensing and enumeration of specific types of circulating cells in small animals is an important problem in many areas of biomedical research. Microscopy-based fluorescence in vivo flow cytometry methods have been developed previously, but these are typically limited to sampling of very small blood volumes, so that very rare circulating ...
Lin Ming Xian - - 2012
Circulating tumor cells (CTCs) are identified in transit within the blood stream of cancer patients and have been proven to be a main cause of metastatic disease. Current approaches for the size-based isolation of CTCs have encountered technical challenges as some of the CTCs have a size similar to that ...
Imai Kazuhiro - - 2012
PURPOSE: Lymphatic spread of lung carcinoma to the mediastinum is a key determinant of prognosis. The lymph flow often carries metastases from the pulmonary segment directly into the mediastinal lymph nodes, without passing through the hilar nodes. This phenomenon is termed as "skip metastasis." This study investigated the subpleural lymphatic ...
Li Xiufeng X Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN 55455, - - 2013
Prostate perfusion has the potential to become an important pathophysiological marker for the monitoring of disease progression or the assessment of the therapeutic response of prostate cancer. The feasibility of arterial spin labeling, an MRI approach for the measurement of perfusion without an exogenous contrast agent, is demonstrated in the ...
Lin Y - - 2012
In 2006, the Canadian National Advisory Committee on Blood and Blood Products (NAC) developed a transfusion policy framework for the use of off-label recombinant factor VIIa (rFVIIa) in massive bleeding. Because the number of randomised controlled trials has doubled, the NAC undertook a review of the policy framework in 2011. ...
Li Chunyu - - 2012
To set up a point-of-care whole-blood immunoassay system, sample preparation and on-chip storage of conjugate reagents are indispensable functional units. Here, we merge these functions into a deposited microbead plug (DMBP) to simultaneously play the roles of a blood filter and a conjugate reagent carrier. The DMBP was easily fabricated ...
Eum Jun-Ho - - 2012
Carbon coils could be synthesized using C2H2/H2 as source gases and SF6 as an incorporated additive gas under thermal chemical vapor deposition system. Nickel catalyst layer deposition and then hydrogen plasma pretreatment were performed prior to the carbon coils deposition reaction. According to the different reaction processes, the injection time ...
Sato D - - 2012
OBJECTIVES: Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. However, intravascular administration of sclerotic agents into small arteriovenous niduses is often difficult. Extravascular administration of sclerotic agents causes reduction of vascular flow on Doppler echo during clinical sclerotherapy. Therefore, we aimed to investigate whether the extravascular injection of ...
Johnson Paul - - 2012
Fountain Flow Cytometry (FFC) is a simple and inexpensive technology that is adaptable to situations requiring detection and enumeration of cells/organisms at low concentrations, but is limited to particles of relatively high fluorescence intensity. This work presents the basic physics behind the novel scheme Fountain Flow Cytometry employs for the ...
Yan Congqi C Department of Materials Science and Engineering and Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19716, - - 2012
β-hairpin peptide-based hydrogels are a class of injectable solid hydrogels that can deliver encapsulated cells or molecular therapies to a target site via syringe or catheter injection as a carrier material. These physical hydrogels can shear-thin and consequently flow as a low-viscosity material under a sufficient shear stress but immediately ...
He Guolin - - 2012
The perivascular and perineural extension of hematoma has recently been observed in the brain after intracerebral hemorrhage (ICH), which is formed by the leakage of hematoma via the Virchow-Robin spaces (VRS) and the spaces around the nerve fibers (perineurium). The present study investigated the perivascular and perineural extension of a ...
Gravemeier Volker V Emmy Noether Research Group on "Computational Multiscale Methods for Turbulent Combustion", Technische Universität München, Boltzmannstr. 15, D-85747 Garching, Germany; Institute for Computational Mechanics, Technische Universität München, Boltzmannstr. 15, D-85747 Garching, Germany. - - 2012
Neumann boundary conditions prescribing the total momentum flux at inflow boundaries of biomechanical problems are proposed in this study. This approach enables the simultaneous application of velocity/flow rate and pressure curves at inflow boundaries. As the basic numerical method, a residual-based variational multiscale (or stabilized) finite element method is presented. ...
Pokrzywnicka Marta - - 2012
A low-cost and compact complete fluorometric detector dedicated for measurements under conditions of flow injection analysis has been developed. This device is fabricated by integration of light emitting diodes (LEDs) applied in the double role: as the source of light inducing fluorescence and as the detector of light emitted by ...
Youssef K - - 2012
Shear stress is an important physical factor that regulates proliferation, migration and morphogenesis. In particular, the homeostasis of blood vessels is dependent on shear stress. To mimic this process ex vivo, efforts have been made to seed scaffolds with vascular and other cell types in the presence of growth factors ...
Yun B Min - - 2012
Previous experimental and numerical blood studies have shown that high shear stress levels, long exposure times to these shear stresses, and flow recirculation promote thromboembolism. Artificial heart valves, in particular bileaflet mechanical heart valves (BMHVs), are prone to developing thromboembolic complications. These complications often form at the hinge regions of ...
Crandall C G - - 2012
Heat stress results in profound reductions in the capacity to withstand a simulated haemorrhagic challenge; however, this capacity is normalized if the individual is volume loaded prior to the challenge. The present study tested the hypothesis that volume loading during passive heat stress attenuates the reduction in regional blood volumes ...
Koulouris Nickolaos G - - 2012
Patients with severe COPD often exhale along the same flow-volume curve during quite breathing as during forced expiratory vital capacity manoeuvre, and this has been taken as indicating expiratory flow limitation at rest (EFL(T)). Therefore, EFL(T), namely, attainment of maximal expiratory flow during tidal expiration, occurs when an increase in ...
Huang Yueh-Chu - - 2011
It has been suggested that minimisation of energy cost is one of the primary determinants of wheelchair designs. Wheel camber is one important parameter related to wheelchair design and its angle may affect usability during manual propulsion. However, there is little available literature addressing the effect of wheel camber on ...
Shaw Tyler - - 2011
Transcranial Doppler sonography was used to measure bilateral cerebral blood flow velocity during sustained attention task performance where the background event schedule occurred in a synchronous (temporally regular) or asynchronous (temporally irregular) manner. Perceptual sensitivity was greater in the synchronous case and declined over time in both conditions. Blood flow ...
Assmann Alexander - - 2011
Controversy on superiority of pulsatile versus non-pulsatile extracorporeal circulation in cardiac surgery still continues. Stroke as one of the major adverse events during cardiopulmonary bypass is, in the majority of cases, caused by mobilization of aortic arteriosclerotic plaques that is inducible by pathologically elevated wall shear stress values. The present ...
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