Search Results
Results 1 - 50 of 1347
1 2 3 4 5 6 7 8 9 10 >
Stefaniotou Antonia A MSc Program Cardiopulmonary Resuscitation, University of Athens, Medical School, Greece, 75 Mikras Asias street, 11527, Athens, - - 2014
The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocardial and cerebral organ blood flow. ...
Guerci Philippe P School of Surgery, Faculty of Medicine, Vandoeuvre-Les-Nancy, - - 2014
The choice of volume expander for fluid resuscitation in hemorrhagic shock is still debated. Changes in plasma viscosity (PV) are barely investigated while PV modulates functional capillary density, microcirculation and organ function. The present study evaluated the impact of 2 strategies of fluid resuscitation in hemorrhagic shock in pigs. Ten ...
Del Pilar Huby Maria M Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, - - 2014
Rodent models of hemorrhagic shock are paramount to our understanding of the pathophysiology of this disease, effects on coagulation, and exploring the utility of resuscitative methods for managing patients in shock. These models usually require serial blood sampling during experimentation. The lack of standardized practices for these experimental models has ...
Kelm Robert F RF 1Department of Anesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. 2Department of Neuropathology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. 3Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University, Mainz, - - 2014
Despite advances in cardiac arrest treatment, high mortality and morbidity rates after successful cardiopulmonary resuscitation are still a major clinical relevant problem. The post cardiac arrest syndrome subsumes myocardial dysfunction, impaired microcirculation, systemic inflammatory response, and neurological impairment. The calcium-sensitizer levosimendan was able to improve myocardial function and initial resuscitation ...
Mallat Jihad J From the Intensive Care Unit, Centre Hospitalier du Dr Schaffner de Lens, Lens (JM, FP, ML, GG, NV, LT, DT), Department of Anaesthesiology and Critical Care Medicine, University Hospital of Lille, Univ Nord de France, Lille, France - - 2014
Central venous-to-arterial carbon dioxide partial pressure difference (ΔPCO2) can be used as a marker for the efficacy of venous blood in removing the total CO2 produced by the tissues. To date, this role of ΔPCO2 has been assessed only in patients after resuscitation from septic shock with already normalised central ...
Wang Dong D Critical Care Medicine Department, Clinical Center, NIH, Bethesda, - - 2014
In experimental pneumonia we found that transfused older blood increased mortality and lung injury that was associated with increased in vivo hemolysis and elevated plasma cell-free hemoglobin (CFH), non-transferrin-bound iron (NTBI), and plasma labile iron (PLI) levels. In this study, we additionally analyze identically treated animals that received lower or ...
Qian Jie J Weil Institute of Critical Care Medicine, Rancho Mirage, CA; Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: - - 2014
Post-resuscitation syndrome has been recognized as one of the major causes of the poor outcomes of cardiopulmonary resuscitation. The aims of this study were to investigate the intestinal microcirculatory changes following cardiopulmonary resuscitation and relate those changes to sublingual microcirculation and the severity of post-resuscitation syndrome as measured by myocardial ...
Sun Nannan N Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Biomedical Engineering, Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, PR China; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Biochemistry and Biophysics, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, - - 2014
Our long-term goals are to identify imaging biomarkers for hemorrhagic shock and to understand how the preservation of cerebral microcirculation works. We also seek to understand how the damage occurs to the cerebral hemodynamics and the mitochondrial metabolism during severe hemorrhagic shock. We used a multimodal cerebral cortex optical imaging ...
Rivera-Chávez Fernando A FA Division of Burn/Trauma/Critical Care, UT Southwestern Medical Center , Dallas, Texas , - - 2014
ABSTRACT Objective: To evaluate neutrophil activation after exposure to standard HBC-201 (suspended in lactate Ringer's solution) versus HBOC-201 suspended in hypertonic 7.5% saline solution. Methods: We use plasma and tissue obtained from pigs subjected to controlled hemorrhagic shock and an ex vivo model of stimulated human whole blood. The pigs ...
Ball Chad G CG From the University of Calgary and Foothills Medical Centre, Calgary, - - 2014
Damage control resuscitation (DCR) represents the natural evolution of the initial concept of damage control surgery. It currently includes early blood product transfusion, immediate arrest and/or temporization of ongoing hemorrhage (i.e., temporary intravascular shunts and/or balloon tamponade) as well as restoration of blood volume and physiologic/hematologic stability. As a result, ...
Peruski Ann M AM Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, - - 2014
Objective-To determine whether increasing the viscosity of a standard hemoglobin-based oxygen-carrying solution (HBOC) would offset its associated vasoconstrictive effects and result in improved microvascular perfusion in healthy splenectomized dogs with experimentally induced hemorrhagic shock. Animals-12 male American Foxhounds. Procedures-Each dog underwent anesthesia and splenectomy. Shock was induced by controlled hemorrhage ...
Mehrabadi Azar A Department of Obstetrics and Gynaecology, and the School of Population and Public Health, University of British Columbia, and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver - - 2014
Objective: Increases in postpartum hemorrhage have been reported from several countries. We assessed temporal trends in postpartum hemorrhage and severe postpartum hemorrhage in Canada between 2003 and 2010. Methods: We carried out a population-based cohort study of all hospital deliveries in Canada (excluding Quebec) from 2003 to 2010 (n = ...
Pereira Flávia Helena FH Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais, MachadoMG, Brazil, MSc, Professor, Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais, Machado, MG, - - 2014
to investigate whether there is a relationship between plasmatic levels of nitrate, body temperature, and blood pressure values in patients with sepsis, severe sepsis and septic shock. prospective observational study performed in a Brazilian hospital; data were collected from July to December 2009. Thirty blood samples were obtained from a ...
Skorup Paul P Section of Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, - - 2014
This study aimed to determine whether the addition of an aminoglycoside to a ß-lactam antibiotic increases the antimicrobial effect during the early phase of Gram-negative severe sepsis/septic shock. A porcine model was selected that considered each animal's individual blood bactericidal capacity. Escherichia coli, susceptible to both antibiotics, was given to ...
Tara Shuhei S Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical - - 2014
Background: Because direct application of low-energy shock waves induces angiogenesis, we investigated the safety and efficacy of this new therapy to develop a noninvasive method of repeatable therapeutic angiogenesis for treating peripheral arterial disease (PAD). Subjects and Methods: The subjects were 10 patients who had symptomatic PAD and limited ischemia ...
Idris Azam Che AC Faculty of Engineering, National Defence University of Malaysia, Kem Sungai Besi, Kuala Lumpur 57000, Malaysia. - - 2014
Scramjets have become a main focus of study for many researchers, due to their application as propulsive devices in hypersonic flight. This entails a detailed understanding of the fluid mechanics involved to be able to design and operate these engines with maximum efficiency even at their off-design conditions. It is ...
Sun Nannan N Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China, - - 2014
Understanding the biological mechanism and identifying biomarkers of hemorrhagic shock is important for diagnosis and treatment. We aim to use optical imaging to study how the cerebral blood circulation and metabolism change during the progression of severe hemorrhagic shock, especially the decompensatory stage. We used a multi-parameter (blood pressure (BP), ...
Jansen J O JO 144 Parachute Medical Squadron, 16 (Air Assault) Medical Regiment, and Aberdeen Royal Infirmary, Aberdeen, - - 2013
To document blood component usage in the UK medical treatment facility, Afghanistan, over a period of 4 years; and to examine the relationship with transfusion capability, injury pattern and survival. Haemostatic resuscitation is now firmly established in military medical practice, despite the challenges of providing such therapy in austere settings. ...
Cortés-Puch Irene I Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, United - - 2013
In a randomized controlled blinded trial, two-year-old purpose-bred beagles (n=24) with S. aureus pneumonia, were exchanged-transfused with either 7- or 42-day-old washed or unwashed canine universal donor blood (80 ml/kg in 4 divided doses). Washing red cells (RBC) before transfusion had a significantly different effect on canine survival, multiple organ ...
Strandenes G G 1Norwegian Naval Special Operation Commando, Bergen, Norway 2Dept. of Immunology and Transfusion Medicine, Haukeland University Hospital, and Institute of Clinical Science, University of Bergen, Bergen, Norway 3Deployment Medicine International, P.O. Box 1264Gig Harbor, WA 98335 4U.S. Army Institute of Surgical Research, FT Sam Houston, TX, USA 5Naval Special Warfare Development Group Virginia Beach, Virginia 23461-2299 USA 6Specialist Corps, U.S. Army, Keller Army Community Hospital, West Point, New York 10996 USA 7Department of Transfusion Medicine, Örebro University Hospital, Orebro, Sweden 8NSWDG US Navy Virginia Beach, VA, USA 9Medical Operations Royal Caribbean Cruises Ltd. 305-982-2890 / ext. 32890 10Department of Pediatrics, Division of Critical Care, Washington University in St Louis, St. Louis, MO, - - 2013
Military experience and recent in-vitro laboratory data provide a biological rationale for whole blood use in the treatment of exsanguinating hemorrhage and have renewed interest in the re-introduction of fresh whole blood(FWB) and cold stored Whole Blood(WB) to patient care in austere environments. There is scant evidence to support, in ...
Ploen Robert R Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, - - 2013
The management of acute ischemic stroke during anticoagulation with a novel oral anticoagulant (NOAC) is challenging because intravenous thrombolysis is contraindicated because of a putative increased risk of intracerebral hemorrhagic complications. We examined the risk of secondary postischemic hemorrhage after thrombolysis in rodents pretreated with rivaroxaban or warfarin. Mice were ...
Ballabh Praveen P Department of Pediatrics, Cell Biology and Anatomy, Regional Neonatal Center, New York Medical College, Maria Fareri Children's Hospital, Westchester Medical Center, 100 Woods Road, Valhalla, NY 10595, USA. Electronic address: - - 2014
Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of ...
Martini Wenjun Z - - 2013
Ongoing improvements in trauma care now recommend earlier use of blood products as part of damage control resuscitation, but generally these products are not available at far forward battlefield locations. For the military, questions continue to arise regarding efficacy of normal saline (NS) vs. lactated Ringer's (LR). Thus, this study ...
Ortiz Daniel D Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA. Electronic address: - - 2013
The development of an alternative to blood transfusion to treat severe hemorrhage remains a challenge, especially in far forward scenarios when blood is not available. Hemoglobin level (Hb)-based oxygen (O2) carriers (HBOCs) were developed to address this need. Hemopure (HBOC-201, bovine Hb glutamer-250; OPK Biotech, Cambridge, MA), one such HBOC, ...
Schiraldi R - - 2013
Massive postpartum haemorrhage is a major worldwide cause of maternal mortality. Management requires intensive fluid resuscitation and blood transfusion. Although fluid therapy is often directed by the results of a full blood count and clotting screen, recent technological advances allow monitoring of haemodynamic function and cardiac output. Transoesophageal Doppler technology ...
Le Bas Abigail A Department of Obstetrics and Gynaecology, St George's Healthcare NHS Trust, London, UK. Electronic address: - - 2013
To establish the normal range for the "obstetric shock index" (OSI) after birth and to determine its usefulness as an aid to estimate blood loss in postpartum hemorrhage (PPH). A retrospective case-control analysis was conducted involving pregnant women admitted to St Georges Hospital for delivery: 50 with no PPH (control ...
Keene Damian D - - 2013
Haemorrhage from major trauma is a significant cause of death worldwide. The UK Defence Medical Service (UK-DMS) has had significant experience in managing severely injured and shocked trauma casualties over the last decade. This has led to the integration of rotational thromboelastometry (ROTEM) into damage control resuscitation delivered at Camp ...
Spinella Philip C - - 2013
The philosophy of DCR and RDCR can be summarized by stating that the goal is to prevent death from hemorrhagic shock by 'staying out of trouble instead of getting out of trouble'. In other words, it is preferred to arrest the progression of shock, rather than also having to reverse ...
Mallat J - - 2013
Determining the venous-to-arterial PCO2 difference (PCO2gap) during resuscitation of septic shock patients might be useful when deciding when to continue resuscitation despite a ScvO2 >70% associated with hyperlacticemia. Because hyperlacticemia is not a discriminatory factor in defining the cause of that stress, a PCO2gap >6 mmHg could be used to ...
Chen Bo - - 2013
Traumatic brain injury (TBI) and hemorrhagic shock (HS) are the leading causes of death in trauma. Recent studies suggest that TBI may influence physiological responses to acute blood loss. This study was designed to assess to what extent superimposed TBI may modulate physiologic vasomotor responses in third-order blood vessels in ...
Soubeyrand Marc - - 2013
In the acute phase of spinal cord injury (SCI), ischemia and parenchymal hemorrhage are believed to worsen the primary lesions induced by mechanical trauma. To minimize ischemia, keeping the mean arterial blood pressure above 85 mmHg for at least 1 week is recommended, and norepinephrine is frequently administered to achieve this goal. ...
Vuković Dragan D School of Medicine, University of Belgrade, Belgrade, Serbia. - - 2013
The course and prognosis of vitreous hemorrhage (VH) are difficult to predict in spite of so far published experimental and clinical studies. The goal of this study was to follow the course and evaluate prognosis of vitreous hemorrhage. The experiment was performed on 19 Chinchilla rabbits (Oryctolagus cuniculus), both males ...
Boue Yvonnick - - 2013
To describe the successful neurologic recovery from profound accidental hypothermia with cardiac arrest despite the longest reported duration of cardiopulmonary resuscitation. Case report. Mountain. A 57-year-old woman experienced profound accidental hypothermia (16.9°C) in a mountainous region of Grenoble. She was unconscious and had extreme bradycardia (6 beats/min) at presentation. A ...
Molnar M - - 2013
Hyperglycaemia is associated with aggravated ischaemic brain injury. The main objective of this study was to investigate the effects on cerebral perfusion of 5 min of cardiac arrest during hyperglycaemia and normoglycaemia. Twenty triple-breed pigs (weight: 22-29 kg) were randomised and clamped at blood glucose levels of 8.5-10 mM [high (H)] or 4-5.5 mM ...
Carreira Serge - - 2013
Acute diaphragmatic dysfunction has been reported in septic and cardiogenic shock, but few data are available concerning the effect of hemorrhagic shock on diaphragmatic function. The authors examined the impact of a hemorrhagic shock on the diaphragm. Four parallel groups of adult rats were submitted to hemorrhagic shock induced by ...
Torres Luciana N - - 2013
Endothelial glycocalyx (EG) plays an essential role in endothelium integrity and may be compromised by hemorrhagic shock. The effects of currently available resuscitation fluids such as Hextend (HEX) or lactated Ringer's solution (LR) on vascular function and coagulation are not well understood. The aim of the present study was to ...
Gavin James P - - 2013
This study examined the reproducibility of speed corresponding to specific lactate markers during incremental treadmill running of normal and prolonged stage durations. Nineteen healthy participants (14 male, 5 female) performed repeated, incremental treadmill running trials of 4 and 8min stages on separate days to examine the test-retest reproducibility of speed ...
Lee Jae Hyuk - - 2013
Hemorrhagic shock, and subsequent resuscitation leads to global ischemia/reperfusion injury. It may result in multiple organ injury and death. Ischemic post-conditioning has been suggested to reduce organ injury. It may lead to gradual increase in tissue oxygen delivery and tissue acidosis may be reduced gradually. Gradual increase of blood pressure ...
Martin Anne-Céline - - 2013
As all anticoagulants, apixaban exposes to a bleeding risk, thus an effective way to reverse its effects is needed. Objectives were to study efficacy and safety of recombinant activated factor VII (rFVIIa), prothrombin complex concentrate (PCC), and fibrinogen concentrate (Fib) to reverse apixaban in a rabbit model of bleeding and ...
Hwabejire John O - - 2013
Cerebral metabolic derangement and excitotoxicity play critical roles in the evolution of traumatic brain injury (TBI). We have shown previously that treatment with large doses of valproic acid (VPA) decreases the size of brain lesion. The goal of this experiment was to determine whether this effect was owing to metabolic ...
Morelli Andrea - - 2013
β-blocker therapy may control heart rate and attenuate the deleterious effects of β-stimulating catecholamines in septic shock. However, their negative chronotropy and inotropy may potentially lead to an inappropriately low cardiac output, with a subsequent compromise of microvascular blood flow. The purpose of the present pilot study was to investigate ...
Kutcher Matthew E - - 2013
IMPORTANCE The evolution of damage control strategies has led to significant changes in the use of resuscitation after traumatic injury. OBJECTIVE To evaluate changes in the administration of fluids and blood products, hypothesizing that a reduction in crystalloid volume and a reduced red blood cell (RBC) to fresh frozen plasma ...
Yang Lin - - 2013
The effect of rescue breathing on neurologic prognosis after cardiopulmonary resuscitation (CPR) is controversial. Therefore, we investigated the cerebral microcirculatory and oxygen metabolism during continuous compression (CC) and 30:2 CPR (VC) in a porcine model of cardiac arrest to determine which is better for neurologic prognosis after CPR. After 4 ...
Kanawade Rajesh - - 2013
The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed ...
Sasi Arun - - 2013
To determine delivered O2 concentration (dFiO2 ) during manual inflations using neonatal self-inflating resuscitation bags (SIBs) at oxygen (O2 ) flow rates <1 L/min. This experimental study, determined dFiO2 during 216 sets of manual inflations at different O2 flow rate (L/min; 0.2, 0.4, 0.6, 0.8, 1.0 and 5.0), controlling peak inspiratory ...
Caixeta Daniella Mancino da Luz - - 2013
To report the sublingual microcirculation observed using Sidestream Dark Field imaging in two children with dengue shock. Two children, aged 9 and 10 years, were admitted to the pediatric intensive care unit with dengue shock and multiple organ dysfunction. Sublingual microcirculation was assessed in each patient on the first and ...
Wade Charles E - - 2013
The impact of do-not-resuscitate (DNR) orders has not been systematically evaluated in acute trauma research. We determined the frequency, timing, and impact on mortality-based effect estimates for patients with DNR orders in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study. Trauma patients surviving at least 30 minutes and transfused ...
Tapia Nicole M - - 2013
Damage-control resuscitation is the prevailing trauma resuscitation technique that emphasizes early and aggressive transfusion with balanced ratios of red blood cells (RBCs), plasma (FFP), and platelets (Plt) while minimizing crystalloid resuscitation, which is a departure from Advanced Trauma Life Support (ATLS) guidelines. It is unclear whether the newer approach is ...
Callan M B - - 2013
BACKGROUND AND OBJECTIVES: Studies in mice suggest that rapid transfusions of red blood cells (RBCs), refrigerator stored for longer durations, induce a pro-inflammatory cytokine response. Studies in human neonates confirm these findings; however, to date, adult human studies have failed to replicate these findings. We used healthy research dogs to ...
Wernick Morena B - - 2013
The objective of this study was to compare the effects of 3 different fluid types for resuscitation after experimentally induced hemorrhagic shock in anesthetized chickens and to evaluate partial pressures of carbon dioxide measured in arterial blood (Paco2), with a transcutaneous monitor (TcPco2), with a gastric intraluminal monitor (GiPco2), and ...
1 2 3 4 5 6 7 8 9 10 >