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Chan Andrew S L - - 2011
Flow-volume curves have been shown to relate to upper airway physiology during sleep and may be useful for predicting the response to treatment of obstructive sleep apnea (OSA) with mandibular advancement splints (MAS). The aim of this study was to prospectively assess the potential clinical utility of a previously derived ...
Visser Frank J - - 2011
Background: In patients with severe chronic obstructive pulmonary disease (COPD), pursed-lips breathing (PLB) improves the pulmonary gas exchange and hyperinflation measured by electro-optic coupling. The response to PLB in inspiratory lung function tests is not known. Objectives: The purpose of this study was to measure the effect of PLB on ...
Hira Daiki - - 2010
To construct a simple simulator reproducing human inspiratory flow patterns and use it to evaluate the inhalation performance of active ingredient particle-carrier particle systems (physically mixed dry powders). Inspiratory flow patterns were collected and analyzed using a flow recorder. The simulator was constructed using an airtight container, a valve, and ...
Pardali D - - 2010
BACKGROUND: Tracheoscopy is generally used for the diagnosis of tracheal collapse (TC) in dogs; yet, it is costly, requires anesthesia, and can irritate the airway. The tidal breathing flow-volume loop (TBFVL) is a safe, quick, and noninvasive pulmonary function test currently used in humans. HYPOTHESIS: TBFVL will differentiate dogs with ...
Hamahata Atsumori - - 2010
The authors devised a novel bronchial artery catheterization technique to deliver agents directly into bronchial circulation with preserved blood flow in an awake ovine model. A polyurethane catheter was inserted into bronchial artery via an incision into the 4th intercostal space. Regional blood flow of the airway was measured by ...
Walsh Brian K - - 2010
The incidence of congenital diaphragmatic hernia has been reported as 0.17-0.66 per 1,000 births. Despite advances in neonatal intensive care, congenital diaphragmatic hernia is associated with high mortality and morbidity. We report a neonate who was born with a left congenital diaphragmatic hernia and underwent surgical repair. The lack of ...
Schmidt Matthieu - - 2010
BACKGROUND: Neurally adjusted ventilatory assist (NAVA) is a partial ventilatory support mode where positive pressure is provided in relation to diaphragmatic electrical activity (EAdi). Central inspiratory activity is normally not monotonous, but it demonstrates short-term variability and complexity. The authors reasoned that NAVA should produce a more "natural" or variable ...
Kluger Elissa K - - 2010
OBJECTIVE: To evaluate agreement between 2 portable triglyceride meters and a veterinary laboratory for measurement of blood triglyceride concentrations in dogs and evaluate effects of Hct and blood volume analyzed. SAMPLE POPULATION: 97 blood samples collected from 60 dogs. PROCEDURES: Triglyceride concentrations were measured in blood by use of 2 ...
Puckett James L - - 2010
Exhaled nitric oxide (eNO) is elevated in asthmatics and is a purported marker of airway inflammation. By measuring eNO at multiple flows and applying models of eNO exchange dynamics, the signal can be partitioned into its proximal airway [J' aw NO (nl/sec)] and distal airway/alveolar contributions [CA(NO)(ppb)]. Several studies have ...
Mirck Jaconette - - 2010
Sap flow of four shrub willow varieties was measured to study their potential use as an evapotranspiration (ET) cover on the Solvay wastebeds to reduce deep percolation and leaching of chloride. Stem and stand-level sap flow and crop coefficients (K(c)) were different among four willow varieties measured between early June ...
Grassi P - - 2010
Hemoglobin oxygen saturation in superior vena cava (ScvO(2)) is used as a parameter to guide hemodynamic management in shock patients and it can be continuously read through a central venous catheter equipped with a fiberoptic spectrophotometric probe (Edwards PreSep catheter) connected to a specific monitor (Edwards Vigileo). We report of ...
Torres Juan Pablo - - 2010
Respiratory Syncytial Virus (RSV) infection is usually restricted to the respiratory epithelium. Few studies have documented the presence of RSV in the systemic circulation, however there is no consistent information whether virus detection in the blood correlates with disease severity. Balb/c mice were inoculated with live RSV, heat-inactivated RSV or ...
Malmberg L Pekka - - 2010
Dry powder inhalers (DPIs) are inspiratory flow driven and hence flow dependent. Most patients with chronic obstructive pulmonary disease (COPD) are elderly and have poor lung function. The factors affecting their inspiratory flows through inhalers are unclear. To study peak inspiratory flows (PIFs) and their determinants through a DPI in ...
Yang Xing X MEMS Lab, Department of Precision Instruments & Mechanology, Tsinghua University, 100084, Beijing, China. - - 2010
A new type of hot-wire flow-rate sensor (HWFS) with a sensing element made of a macro-sized carbon nanotube (CNT) strand is presented in this study. An effective way to improve repeatability of the CNT flow-rate sensor by coating a layer of Al(2)O(3) on the CNT surface is proposed. Experimental results ...
Abdelrahim Mohamed E - - 2010
Turbuhaler has a very high resistance hence patient inhalation flow when using it would be low. The total emitted dose (TED) of 500microg terbutaline sulphate from a Bricanyl Turbuhaler was determined using a range of inhalation flows (10-60L min(-1)) with inhalation volume of 2 and 4L using a DPI sampling ...
Harver Andrew - - 2009
We administered a 65-item survey to patients to assess preference of symptoms and peak flow to detect worsening asthma and to collect information about asthma triggers, asthma knowledge sources, and barriers to peak flow meter use. It was completed by 139 asthma patients. Survey responses were comparable for adult and ...
Abel Richard L - - 2010
We describe several novel morphological features in the nasal region of the hammerhead shark Sphyrna tudes. Unlike the open, rounded incurrent nostril of non-hammerhead shark species, the incurrent nostril of S. tudes is a thin keyhole-like aperture. We discovered a groove running anterior and parallel to the incurrent nostril. This ...
Pesola Gene R - - 2009
OBJECTIVES: U.S. prediction equation estimated peak flows were obtained spirometrically and may not correctly predict actual peak flows that are obtained using a peak flow meter. The purpose of this investigation was to compare actual Mini Wright peak flows in normal volunteers as compared with spirometric predicted values to determine ...
Hansen Jens Georg - - 2009
OBJECTIVE: To evaluate the influence of acute rhinosinusitis on lung function as measured by spirometry. METHOD: An observational study in Danish general practice on 25 adult patients with a clinical diagnosis of acute rhinosinusitis and without any signs of chronic lung disease or allergy. Patients performed spirometry at the initial ...
Parker James Courtney - - 2009
A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using ...
Paredi P - - 2009
It is increasingly recognised that the airway circulation plays an important role in airway diseases, either through a change in blood flow or through microvascular leakage. Most of the information available regarding the anatomy and physiology of bronchial blood flow and its regulation has necessarily derived from animal studies. However, ...
Tenhunen M - - 2009
A nasal pressure transducer, which is used to study nocturnal airflow, also provides information about the inspiratory flow waveform. A round flow shape is presented during normal breathing. A flattened, non-round shape is found during hypopneas and it can also appear in prolonged episodes. The significance of this prolonged flow ...
Modrykamien Ariel M - - 2009
BACKGROUND: There are important gaps in our understanding of the epidemiology and diagnosis of upper-airway obstruction. METHODS: We examined the diagnostic value of several criteria for predicting upper-airway obstruction, and we measured the frequency of detecting upper-airway obstruction via quantitative and visual assessment of flow-volume loops. We studied 4 quantitative ...
Sterner James B - - 2009
BACKGROUND: The 2005 American Thoracic Society/European Respiratory Society guidelines on spirometry emphasize examination of the inspiratory curve of the flow-volume loop for evidence of intrathoracic or extrathoracic upper airway obstruction. We sought to determine how frequently evaluations are performed for abnormal inspiratory curves. METHODS: We retrospectively reviewed all examinations performed ...
Watson Maura A - - 2009
BACKGROUND: Vocal cord dysfunction (VCD) is difficult to diagnose. Laryngoscopy while the patient is symptomatic is the accepted standard method to establish a diagnosis of VCD, but patient characteristics and spirometry values are thought to be useful for predicting VCD. We sought to identify clinical and spirometric variables that suggest ...
Aggarwal Ashutosh N - - 2009
Lung function in 1686 adult patients was measured before, and 15 minutes after, salbutamol inhalation. Bronchodilator responsiveness (BDR) was defined as a 12% improvement over baseline in either FEV1 or FVC, along with an absolute volume increment of 200 ml. Peak expiratory flow (PEF) change, both absolute and relative to ...
Jiamsripong Panupong - - 2009
Analysis of intraventricular flow force and efficiency is a novel concept of quantitatively assessing left ventricular (LV) hemodynamic performance. We have parametrically characterized diastolic filling flow by early inflow force, late inflow force, and total inflow force and by vortex formation time (VFT), a fundamental parameter of fluid transport efficiency. ...
Banno Masashi - - 2009
Background: The recently released handheld In-Check device can be used to measure the peak inspiratory flow rate (PIF) of patients and is reportedly useful in determining whether the PIF is sufficient for using inhaler devices. In this study, we evaluated the effects of instructions for the use of the device ...
Robert Raymond - - 2009
Liquid-assisted ventilation (LAV) using perfluorochemicals (PFC) offers clear theoretical advantages over gas ventilation. During tidal liquid ventilation (TLV) the residual capacity of the lungs is filled with PFC and a liquid ventilator is necessary to inhale and exhale the tidal volume of PFC. However, during the expiration phase, a flow ...
Mihaescu Mihai - - 2009
OBJECTIVES/HYPOTHESIS: The aim of this study was to perform computer simulations of flow within an accurate model of a pediatric airway with subglottic stenosis. It is believed that the airflow characteristics in a stenotic airway are strongly related to the sensation of dyspnea. METHODS: Computed tomography images through the respiratory ...
Ohkura Noriyuki - - 2009
BACKGROUND: Cough in the patients with cough variant asthma is triggered by bronchoconstriction, which responds to bronchodilator therapy. Following airway narrowing induced by inhaled methacholine, deep inspiration (DI) causes dilation of the airways in both asthmatic and non-asthmatic subjects. The aim of the present study was to investigate the relationship ...
Rodrigo Gustavo J - - 2009
PURPOSE OF REVIEW: To analyze the prediction of response of therapy into the context of acute adult asthma assessment in the emergency department (ED) setting. RECENT FINDINGS: Close monitoring of the patient's condition at presentation (static assessment) and response to treatment (dynamic assessment), including serial measurements of lung function, is ...
Nik Hisamuddin N A R - - 2009
The usual method for initial assessment of an acute asthma attack in the emergency room includes the use of peak flow measurement and clinical parameters. Both methods have their own disadvantages such as poor cooperation/effort from patients (peak flow meter) and lack of objective assessment (clinical parameters). We were looking ...
Ma Rong-Hua - - 2009
This study develops a MEMS-based low-cost sensing platform for sensing gas flow rate and flow direction comprising four silicon nitride cantilever beams arranged in a cross-form configuration, a circular hot-wire flow meter suspended on a silicon nitride membrane, and an integrated resistive temperature detector (RTD). In the proposed device, the ...
Gregory N G - - 2009
Bovine respiratory tracts were examined for blood following shechita without stunning, halal slaughter without stunning, and captive bolt stunning with sticking. In all three methods the cattle were in the upright (standing) position at the start of bleeding. Those that had not been stunned continued to breathe during the early ...
Sepponen Anna - - 2008
Exhaled nitric oxide (NO) concentration is a marker of pulmonary inflammation. It is usually measured at a single exhalation flow rate. However, measuring exhaled NO at multiple flow rates allows assessment of the flow-independent NO parameters: alveolar NO concentration, bronchial NO flux, bronchial wall NO concentration, and bronchial diffusing capacity ...
Denlinger Loren C LC Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P.O. Box 9988, Madison, WI 53792, USA. - - 2009
Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens. We hypothesized that variability in P2X(7) function contributes to neutrophilic airway inflammation during a cold and thereby is ...
Lin Shu-Hui - - 2009
In addition to the Poiseuille effect, a so-called temporal effect was proposed recently to elucidate the commonly observed tailing peak signals of flow injection analysis (FIA). A multi-channel absorbance detector was used in this study to obtain the FIA peaks on both the spatial and temporal coordinates. The temporal effect ...
Doorly D J - - 2008
Current approaches to model nasal airflow are reviewed in this study, and new findings presented. These new results make use of improvements to computational and experimental techniques and resources, which now allow key dynamical features to be investigated, and offer rational procedures to relate variations in anatomical form. Specifically, both ...
Teng ZhongZhao - - 2008
Trachea is the unique passage for air to flow in and out. Its tone is of importance for the respiration system. However, investigation on how tracheal tone changes due to asthma is limited. Aiming at studying how the mechanical property changes due to asthma as well as the compliance and ...
Holzman Roi - - 2008
During ontogeny, animals undergo changes in size and shape that result in shifts in performance, behavior and resource use. These ontogenetic changes provide an opportunity to test hypotheses about how the growth of structures affects biological functions. In the present study, we ask how ontogenetic changes in skull biomechanics affect ...
Choong Cliff K - - 2008
By creating artificial communications through bronchial walls into the parenchyma of explanted lungs (airway bypass), we expect to decrease the amount of gas trapped and to increase the rate and volume of air expelled during forced expirations. To describe the mechanism by which airway bypass improves the mechanical properties of ...
Ha Jonathan K - - 2008
A systematic study on the sources of drift in a turbine-based spirometer (VMM-400) is presented. The study utilized an air-tight cylinder to pump air through the spirometer in a precise and programmable manner. Factors contributing to the drift were isolated and quantified. The drift due to imbalance in the electronics ...
Schmalisch G - - 2009
Continuous positive airway pressure (CPAP) is routinely used for respiratory support in neonates. Air leaks are not uncommon and can hinder treatment. This study compared leak flow data obtained using different leak definitions through modeling and in vitro measurements. METHODS: Using a computer simulation of an ideal CPAP system, the ...
Walker Paul P - - 2008
A significant proportion of patients with COPD show post-bronchodilator improvement in lung volume even though this response is rarely considered when classifying subjects as having reversible or irreversible airway disease. We studied 266 patients with a clinical and physiological diagnosis of COPD who underwent pulmonary function testing and had their ...
Bertram Christopher D - - 2008
The self-excited oscillation of airway structures and flexible tubes in response to flow is reviewed. The structures range from tiny airways deep in the lung causing wheezing at the end of a forced expiration, to the pursed lips of a brass musical instrument player. Other airway structures that vibrate include ...
Brouwer A F J - - 2008
Current reference values for diurnal peak flow variation in healthy children (median 8.2%; 95th percentile 31%) are so high that considerable overlap exists with those of asthmatic children. These values have been obtained using written peak flow diaries, which are unreliable. The aim of the present study was to obtain ...
Gogate Shaila - - 2008
PURPOSE OF REVIEW: Markers of disease status that provide a numerical measure of disease activity, biomarkers, have come into more routine use in medicine. This is evidenced by troponin and brain natriuretic peptide when measuring cardiac function or glomerular filtration rate in relation to kidney function. Similar markers to assess ...
Suresh Vinod - - 2008
Elevated exhaled nitric oxide (NO) in the breath of asthmatic subjects is thought to be a noninvasive marker of lung inflammation. Asthma is also characterized by heterogeneous bronchoconstriction and inflammation, which impact the spatial distribution of ventilation in the lungs. Since exhaled NO arises from both airway and alveolar regions, ...
Alves Luiz Antonio - - 2008
BACKGROUND: The Flutter VRP1 device is used for airway clearance. Its performance is based on 4 basic effects: positive expiratory pressure (PEP), forced exhalations (huff), high-frequency airway flow oscillation, and modification of mucus viscoelasticity. The purpose of this study was to determine the flow and angle conditions in which these ...
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