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Shang Xiaofei - - 2014
Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the ...
Freidja Mohamed L - - 2014
A chronic increase in blood flow in resistance arteries is associated with increased lumen diameter (outward remodeling) and improved endothelium (NO)-mediated relaxation. Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases. Nevertheless, it is impaired in 12 to 24-month old rats and in young Zucker Diabetic Fatty ...
Told Reinhard R Department of Clinical Pharmacology, Medical University of Vienna, Vienna, 1090, - - 2014
Purpose: The Age-Related Eye Disease Study 1 (AREDS1) showed that nutritional supplementation with anti-oxidants and zinc modifies the natural course of AMD. LPS induced oxidative stress diminishes the vasoconstrictor response of retinal vessels to oxygen breathing and was previously shown to be normalized by the AREDS 1 supplements. In the ...
Truong Giang T GT Loma Linda University, United - - 2014
Nitrite has been postulated to provide a reservoir for conversion to nitric oxide (NO), especially in tissues with reduced oxygen levels as in the fetus. Nitrite would thus provide local vasodilation and restore a balance between oxygen supply and need, a putative mechanism of importance especially in the brain. The ...
Faraco Giuseppe G Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, - - 2014
Adequate hydration is essential for normal brain function and dehydration induces cognitive deterioration. In addition, dehydration has emerged as a stroke risk factor. However, it is unknown whether alterations in cerebrovascular regulation are responsible for these effects. To address this issue, C57Bl/6 mice were water deprived for 24 or 48 hours ...
Slator Lois L 1 Respironics Respiratory Drug Delivery (UK) Ltd. , a business of Philips Electronics UK Limited, Chichester, West Sussex, UK - - 2014
Abstract Background: Valved holding chambers (VHCs) are accessory devices for pressurized metered dose inhalers (pMDIs). Use of a VHC may help overcome coordination issues associated with drug delivery via the pMDI alone. Previous work has established that aspects of VHC use, including the time between actuation and inhalation (inhalation delay) ...
Lin Hung Wen HW Department of Neurology, Cerebral Vascular Disease Research Laboratories, University of Miami, Miller School of Medicine, Two Story Laboratory (TSL), Medical Campus, Miami, Florida, - - 2014
We previously showed that inhibition of protein kinase C delta (PKCδ) improves brain perfusion 24 hours after asphyxial cardiac arrest (ACA) and confers neuroprotection in the cortex and CA1 region of the hippocampus 7 days after arrest. Therefore, in this study, we investigate the mechanism of action of PKCδ-mediated hypoperfusion after ...
Fang Shih-Yuan SY Department of Anesthesiology, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, - - 2014
Objective: The blood flow in the arteriovenous (AV) fistula is significantly reduced in diabetic patients. Statins are known to mediate pleiotropic effects in the vascular endothelium and attenuate inflammatory responses. This study tested the vascular protective effect of rosuvastatin in an experimental model of AV fistula. Methods: One week after ...
Lee Dong-Kil DK Korea Institute Geoscience and Mineral Resources (KIGAM), 92 Gwahang-no, Yuseong-gu, Daejeon 305-325, South Korea. Electronic address: - - 2014
A numerical flow analysis for the design of an oxidation pond was conducted to investigate the optimal flow characteristics. This analysis includes the inflow rate and the shape and depth of the oxidation pond. The total area and maximum depth of the pond were 500 m(2) and 3 m, respectively. We defined ...
Liu Chen C Department of Physics, Wake Forest University, Winston-Salem, NC 27109, - - 2014
The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a spherical one, decreased mean corpuscular hemoglobin concentration, varied mean corpuscular volume, reduced integrity of the erythrocyte membrane with formation of microparticles, and ...
Zheng Ruibin R Departments of Radiology, First Affiliated Hospital of China Medical University, 155 Nanjing N St, Shenyang, 110001, Liaoning Province, People's Republic of - - 2013
Vasospasm of both large and small parenchymal arteries may contribute to the occurrence of delayed ischemic neurological deficits, and nitric oxide(NO) is an important mediators in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH). We used a rabbit two-hemorrhage model to investigate changes in plasma NO after SAH, and ...
Naylor Louise H LH School of Sport Science, Exercise and Health, The University of Western Australia, M408, 35 Stirling Highway, Crawley, WA, 6009, Australia, - - 2013
We assessed the impact of an acute bout of hyperglycaemia on nitric oxide (NO)-mediated microvascular function in the skin of adolescents with type 1 diabetes (T1DM). Twelve subjects (12-18 years) with T1DM were randomised into a control (n = 6) or hyperglycaemia (n = 6) group. Hyperinsulinaemic clamps were used to manipulate blood glucose level ...
Aamand Rasmus R 1Center of Functionally Integrative Neuroscience, Aarhus - - 2013
The carbonic anhydrase (CA) inhibitor acetazolamide (AZ) is used routinely to estimate cerebrovascular reserve capacity in patients, as it reliably increases cerebral blood flow (CBF). However, the mechanism by which AZ accomplishes this CBF increase is not entirely understood. We recently discovered that CA can produce nitric oxide (NO) from ...
Chen Yingjie - - 2013
Following coronary artery occlusion growth of collateral vessels can provide an effective blood supply to the dependent myocardium. The ischemia which results in growth of collateral vessels recruits an inflammatory response with expression of cytokines and growth factors, upregulation of eNOS in vascular endothelial cells, and expression of iNOS in ...
Zecher Daniel - - 2013
Transfusion of aged blood has been associated with increased morbidity and mortality in critically ill patients. During storage, erythrocytes release increasing numbers of microvesicles (red blood cell-derived microvesicles [RBC-MVs]). We hypothesized that RBC-MVs mediate some of the deleterious effects of aged blood transfusions. We established a murine transfusion model using ...
Wang Yimeng - - 2013
The most recent American Association of Blood Banks survey found that 40 000 units of blood are required daily for general medicine, hematology/oncology, surgery, and for accident and trauma victims. While blood transfusions are an extremely important component of critical healthcare, complications associated with transfusion of blood components still exist. It ...
Rho Junsung - - 2013
During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their potential value as a quality metric for blood products. The lack of sensitive, standardized MV assays, however, poses a significant ...
Xu Huiyun - - 2013
As a mechano-calcium channel, polycystin2 (PC2) play an important role in the response of renal epithelial cells to fluid flow shear stress. In bone tissue, osteocytes are well known as the main mechanosensory cells, and sensitive to fluid flow stimulus in vitro. In the study, we investigated the effects of ...
Grochot-Przeczek Anna - - 2013
Aims: Heme oxygenase-1 (HO-1) is a cytoprotective enzyme, which can be downregulated in diabetes. Its importance for mature endothelium has been described, but a role in proangiogenic progenitors is not well known. We investigated the effect of HO-1 on angiogenic potential of bone marrow-derived cells (BMDCs) and on blood flow ...
Cho Shinho - - 2013
Indium oxide thin films are deposited on glass substrates at nitrogen flow rates of 0-50% by rf reactive magnetron sputtering and are characterized for their structural, morphological, electrical, and optical properties. The experimental results showed that the control of nitrogen flow rate has a significant effect on the properties of ...
Golub Aleksander S - - 2013
An adequate supply of oxygen (O2) and nutrients is critical for normal organ function. The regulation of local blood flow in organs ensures matching the delivery of materials with the rate of their consumption in tissues. The mechanism by which this happens is thought to operate according to the metabolic ...
Napoli Raffaele - - 2013
To clarify whether the vasoconstrictory response is impaired and to study vascular function in patients with migraine during the headache attack. We studied vascular reactivity in the resistance arteries by using the forearm perfusion technique associated with plethysmography. We measured forearm blood flow by strain-gauge plethysmography during intra-brachial infusion of ...
Venturelli Massimo - - 2013
A spinal cord injury (SCI) clearly results in greater cardiovascular risk, however, accompanying changes in peripheral vascular structure below the lesion, mean the real impact of a SCI on vascular function is unclear. Therefore, utilizing passive leg movement-induced (PLM) hyperemia, an index of nitric oxide (NO)-dependent vascular function, and the ...
Han Sang Myung - - 2013
Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or may not be associated with detectable brain lesions. We examined mediators of long-term potentiation after SAH in rats to determine what processes might be involved. There was a reduction in synapses in the dendritic ...
Dinesh O Chandani - - 2013
Arginine is an indispensable amino acid in neonates; de novo synthesis of arginine occurs in the small intestine (SI) but is reduced during parenteral nutrition (PN), limiting the arginine available to the mucosa. We assessed the effects of route of intake and dietary concentration of arginine on protein synthesis, superior ...
Yang Jiangning J Divison of Cardiology, Department of Medicine, and Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, - - 2013
The theory that red blood cells (RBCs) generate and release nitric oxide (NO)-like bioactivity has gained considerable interest. However, it remains unclear whether it can be produced by endothelial NO synthase (eNOS), which is present in RBCs, and whether NO can escape scavenging by hemoglobin. The aim of this study ...
Faraco Giuseppe G Brain and Mind Research Institute, 407 E 61st St, Room 303, New York, NY 10065. - - 2013
Endothelin-1 (ET1) is a potent vasoconstrictor peptide implicated in the cerebrovascular alterations occurring in stroke, subarachnoid hemorrhage, and brain trauma. Brain or circulating levels of ET1 are elevated in these conditions and in risk factors for cerebrovascular diseases. Most studies on the cerebrovascular effects of ET1 have focused on vascular ...
Min Jin-Young - - 2013
Exposure to cadmium is known to be associated with reducing nitric oxide (NO) production in experimental conditions, but few studies have examined the association between environmental cadmium exposures and exhaled NO in human. We examined the association between blood cadmium levels and exhaled NO levels in a representative sample of ...
Rogers Natasha M NM Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, - - 2013
We tested the hypothesis that the matricellular protein thrombospondin-1 (TSP1), through binding to and activation of the cell receptor CD47, inhibits basal and thermal-mediated cutaneous blood flow. Abnormal and decreased cutaneous blood flow in response to temperature changes or vasoactive agents is a feature of cardiovascular disease and aging. The ...
Wang Chong - - 2013
Atherosclerosis-prone regions of arteries are characterized by complex flow patterns where the magnitude of shear stress is low and direction rapidly changes, termed disturbed flow. How endothelial cells sense flow direction and how it impacts inflammatory effects of disturbed flow are unknown. We, therefore, aimed to understand how endothelial cells ...
Lange Matthias - - 2013
INTRODUCTION: Previous studies demonstrated beneficial effects of early neuronal nitric oxide synthase (nNOS) and subsequent inducible NOS (iNOS) inhibition on the development of multiple organ dysfunctions in septic sheep. However, the effects of NOS inhibition on regional blood flow remained undetermined. The current study was conducted to assess the effects ...
El-Sherry Taymour M - - 2013
In this study we compared the effect of dinoprost and cloprostenol on changes of corpus luteum blood flow during luteolysis. Ten nonlactating cyclic ewes were synchronized with double PGF2α injections 11 days apart. At Day 10, the animals were classified into 2 groups and received the third dose of PGF2α ...
Monahan-Earley R - - 2013
Every biological trait requires both a proximate and evolutionary explanation. The field of vascular biology is focused primarily on proximate mechanisms in health and disease. Comparatively little attention has been given to the evolutionary basis of the cardiovascular system. Here, we employ a comparative approach to review the phylogenetic history ...
Wood Katherine C KC Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, - - 2013
Mice genetically deficient in endothelial nitric oxide synthase (eNOS(-/-)) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. Although the current paradigm holds that this bioactivity derives specifically from the expression of eNOS in endothelium, circulating ...
Soop Anne - - 2013
BACKGROUND: Microparticles (MPs) are small membrane-bound vesicles that arise from activated and dying cells and promote inflammation and thrombosis. To characterize the in vivo release of MPs, we used flow cytometry to measure MPs in the blood of 15 healthy volunteers administered bacterial endotoxin (lipopolysaccharide or LPS) in the presence ...
Metzler-Wilson K - - 2013
The effects of local sensory blockade (topical anaesthesia) on eccrine sweat glands and cutaneous circulation are not well understood. This study aimed to determine whether topical lidocaine/prilocaine alters eccrine sweat gland and cutaneous blood vessel responses. Sweating (capacitance hygrometry) was induced via forearm intradermal microdialysis of five acetylcholine (ACh) doses ...
Rojas-Lemus Marcela - - 2013
Vanadium is an environmental pollutant attached to the smallest air suspended particles that enters into the respiratory tract reaching the systemic circulation. The oxidative state of this element and sex are factors related to its toxicity. In this study, we explored sex-associated genotoxic and cytotoxic differences in a mouse experimental ...
Bao Nirong - - 2013
Hidden blood loss (HBL), commonly seen post total knee or hip arthroplasty, causes postoperative anemia even after reinfusion or blood transfusion based on the visible blood loss volume. The mechanism of HBL remains unclear although more than one theory had tried to explain it. Free fatty acids, metabolites of fatty ...
Kang Sa Do - - 2013
Endothelial cells (ECs) isolated from endothelial progenitor cells in blood have great potential as a therapeutic tool to promote vasculogenesis and angiogenesis and treat cardiovascular diseases. However, current methods to isolate ECs are limited by a low yield with few colonies appearing during isolation. In order to utilize blood-derived ECs ...
Altunhan Hüseyin - - 2013
AIM: The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM). MATERIAL AND METHODS: The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n = 31) and ...
Guo Xuesong - - 2013
In the Orbal oxidation ditch, denitrification is primarily accomplished in the outer channel. However, the detailed characteristics of the flow field and dissolved oxygen (DO) distribution in the outer channel are not well understood. Therefore, in this study, the flow velocity and DO concentration in the outer channel of an ...
de Oliveira Gisele Capanema - - 2013
The aim of the present work was to evaluate the redox and oligomeric effects associated with the human hemoglobin of stored red blood cells that had been previously submitted to gamma radiation. Whole blood was collected from healthy donors and irradiated with 25 Gy of γ-radiation within 24 h of collection. At ...
Alexander Jason T - - 2013
BACKGROUND: Clinical outcomes in transfused patients may be affected by the duration of blood storage, possibly due to red blood cell (RBC)-mediated disruption of nitric oxide (NO) signaling, a key regulator of vascular tone and blood flow. STUDY DESIGN AND METHODS: AS-1 RBC units stored up to 42 days were ...
Stark Michael J - - 2013
OBJECTIVE: There is increasing awareness that allogeneic transfusion is potentially harmful in preterm neonates secondary to transfusion related immunomodulation (TRIM). Non-transferrin bound iron (NTBI) may contribute to TRIM by promoting oxidative damage and pro-inflammatory cytokine release. The current study aimed to determine if transfusion early in the neonatal period resulted ...
Kulakova K V - - 2013
The growth of Pliss lymphosarcoma in experimental animals was followed by accumulation oxidative protein modification products and structural simplification of blood plasma facies pattern in the central and peripheral zones. A correlation was found between the tumor volume, blood content of aldehyde and ketone dinitrophenylhydrazones, and structural characteristics of the ...
Harms Christoph - - 2013
Intravenous administration of iron oxide nanoparticles during the acute stage of experimental stroke can produce signal intensity changes in the ischemic region. This has been attributed, albeit controversially, to the infiltration of iron-laden blood-borne macrophages. The properties of nanoparticles that render them most suitable for phagocytosis is a matter of ...
Raval J S - - 2013
BACKGROUND: Changes that occur to red blood cells (RBCs) during routine blood bank storage include decreased deformability, increased haemolysis and oxidative damage. Oxidative injury to the RBC membrane and haemoglobin can affect changes in shape and deformability. Ascorbic acid (AA) is an antioxidant that maintains haemoglobin in a reduced state ...
Guo Song - - 2013
InvestigationSodium nitroprusside (SNP) is a powerful vasodilatory agent that, similarly to glyceryl trinitrate (GTN), releases nitric oxide (NO) but in contrast does not pass the blood-brain barrier. Nevertheless, it has already been used in animal models without any knowledge of its headache-inducing potential. We hypothesized that SNP would induce headache ...
Liu Li - - 2013
BACKGROUND: Superparamagnetic iron-oxide nanoparticles are useful as contrast agents for anatomical, functional and cellular MRI, drug delivery agents, and diagnositic biosensors. Nanoparticles are generally cleared by the reticuloendothelial system (RES), in particular taken up by Kupffer cells in the liver, limiting particle bioavailability and in-vivo applications. Strategies that decrease the ...
Langrish Jeremy P JP University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, - - 2013
Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects. In 2 randomized double-blind crossover studies, healthy nonsmokers were exposed to diesel exhaust or filtered air. Study 1: Bilateral forearm blood ...
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