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Subudhi Andrew W AW Department of Biology, University of Colorado Colorado Springs, Colorado Springs, Colorado, USA Department of Emergency Medicine, University of Colorado Altitude Research Center, Aurora, Colorado, USA - - 2014
The occurrence and implications of changes in cerebral autoregulation (CA) at high altitude are controversial and confounded by differences in methods used to assess CA. To compare two of the most common methods of dynamic CA assessment, we studied 11 young, healthy sea-level residents (6 female, 5 male; 20.5 ± ...
Sartori Marco M Department of Molecular Medicine, University of Padua, Padua - - - 2014
Limited options are available to treat critically ill patients with acute liver failure (ALF) and acute-on-chronic liver failure (AoCLF), therefore we set up an in vitro study in order to test the bilirubin adsorption capacity of the Lixelle S-35 cartridge by direct hemoperfusion (DHP). Mock DHP was performed for 120 ...
Huang Brendan K BK Department of Biomedical Engineering, Yale University, New Haven, USA, - - 2014
Cilia-driven fluid flow is important for multiple processes in the body, including respiratory mucus clearance, gamete transport in the oviduct, right-left patterning in the embryonic node, and cerebrospinal fluid circulation. Multiple imaging techniques have been applied toward quantifying ciliary flow. Here, we review common velocimetry methods of quantifying fluid flow. ...
Gómez Perales Jesús Luis JL Nuclear Medicine Service, Puerta del Mar University Hospital, Avenida Ana de Viya 21, 11009 Cádiz, Spain. Electronic address: - - 2014
In the last years, there has been a growing recognition of the importance of blood volume abnormalities in the pathophysiology of several conditions and, consequently, a growing interest of accurate and rapid volume status assessment. Accordingly, there has been a surge of interest in blood volume analysis by radioisotopic dilution ...
Sakharia A A Department of Oral and Maxillofacial Surgery, Saveetha University, Chennai, Tamil Nadu, India. Electronic address: - - 2014
Compromised maxillary perfusion following Le Fort I osteotomy is a potentially serious complication resulting in hard and/or soft tissue loss. The aim of this study was to compare the change in perfusion between two techniques of posterior maxillary disjunction by intraoperative measurement of maxillary gingival blood flow (GBF). Further, we ...
Martin Joshua J JJ Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, - - 2014
Fiber alignment is the defining architectural characteristic of discontinuous fiber composites and is dictated by shear-dominated processing techniques including flow-injection molding, tape-casting, and mold-casting. However, recent colloidal assembly techniques have started to employ additional forces in fiber suspensions that have the potential to change the energy landscape of the shear-dominated ...
Liu Ying Y MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, Guangdong Province, - - 2014
No published reports have demonstrated the capability of the optical coherence tomography technique for quantifying the optical coherence tomography signal slope, 1/e light penetration depth, and attenuation coefficient of hyperglycemic blood by an in vitro assessment. The purpose of this study was to investigate the effects of hyperglycemia on optical ...
Dierickx Daan - - 2014
Apheresis is a collective term for several activities in which a desirable specific blood component is separated and collected or a harmful component is removed. During the last decades the application of apheresis has expanded to a broad spectrum of diseases due to various studies on the clinical efficacy of ...
Ashdown George W GW Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, London, United - - 2014
We combine total internal reflection fluorescence structured illumination microscopy with spatiotemporal image correlation spectroscopy to quantify the flow velocities and directionality of filamentous-actin at the T cell immunological synapse. These techniques demonstrate it is possible to image retrograde flow of filamentous-actin at superresolution and provide flow quantification in the form of ...
Hansen Peter Møller PM Department of Radiology, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: - - 2014
Volume flow in arteriovenous fistulas for hemodialysis was measured using the angle-independent ultrasound technique Vector Flow Imaging and compared with flow measurements using the ultrasound dilution technique during dialysis. Using an UltraView 800 ultrasound scanner (BK Medical, Herlev, Denmark) with a linear transducer, 20 arteriovenous fistulas were scanned directly on ...
Rakotoarisoa Ifanila I Institut PPRIME UPR 3346, CNRS - Université de Poitiers - ENSMA, Bât. B17 - 6 rue Marcel Doré, 86022 Poitiers Cedex, - - 2014
This study focuses on the identification of intermittent aeroacoustic sources in flows by using the time-domain beamforming technique. It is first shown that this technique can be seen as a time-reversal (TR) technique, working with approximate Green functions in the case of a shear flow. Some numerical experiments investigate the ...
Pineda Zapata J A JA Grupo de Investigación, Instituto de Alta Tecnología Médica (IATM), Medellín, Antioquia, Colombia. Electronic address: - - 2014
The 4D Flow MRI technique provides a three-dimensional representation of blood flow over time, making it possible to evaluate the hemodynamics of the cardiovascular system both qualitatively and quantitatively. In this article, we describe the application of the 4D Flow technique in a 3T scanner; in addition to the technical ...
Barbu Andreea A Department of Medical Cell Biology, Uppsala University, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Sweden. Electronic address: - - 2014
The blood perfusion of pancreatic islets is regulated independently from that of the exocrine pancreas, and is of importance for multiple aspects of normal islet function, and probably also during impaired glucose tolerance. Single islet blood flow has been difficult to evaluate due to technical limitations. We therefore adapted a ...
Yousefi Siavash S Department of Bioengineering, University of Washington, Seattle, WA, 98195, - - 2014
In an optical coherence tomography (OCT) scan from a living tissue, red blood cells (RBCs) are the major source of backscattering signal from moving particles within microcirculatory system. Measuring the concentration and velocity of RBC particles allows assessment of RBC flux and flow, respectively, to assess tissue perfusion and oxygen/nutrition ...
Dyvorne Hadrien H From the Department of Radiology/Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029 (H.D., A.K., G.J., C.B., Y.C., B.T.); Healthcare Sector, Imaging & Therapy Division, Siemens, Erlangen, Germany (A.S.); and Department of Radiology and Biomedical Engineering, Feinberg School of Medicine, Northwestern University, Chicago, Ill - - 2014
Purpose To develop a highly accelerated phase-contrast cardiac-gated volume flow measurement (four-dimensional [ 4D four-dimensional ] flow) magnetic resonance (MR) imaging technique based on spiral sampling and dynamic compressed sensing and to compare this technique with established phase-contrast imaging techniques for the quantification of blood flow in abdominal vessels. Materials ...
Schuster Andreas A Division of Imaging Sciences and Biomedical Engineering; King's College London British Heart Foundation (BHF) Centre of Excellence; National Institute of Health Research (NIHR) Biomedical Research Centre at Guy's and St, Thomas' NHS Foundation Trust; Wellcome Trust and Engineering and Physical Sciences Research Council (EPSRC) Medical Engineering Centre, The Rayne Institute, St, Thomas´ Hospital, London, UK. - - 2014
Cardiovascular Magnetic Resonance (CMR) myocardial perfusion imaging has the potential to evolve into a method allowing full quantification of myocardial blood flow (MBF) in clinical routine. Multiple quantification pathways have been proposed. However at present it remains unclear which algorithm is the most accurate. An isolated perfused, magnetic resonance (MR) ...
Catalano Liviana L National Blood Centre, Italian National Institute of Health, Rome, - - 2014
Pre-operative donation of autologous blood is a practice that is now being abandoned. Alternative methods of transfusing autologous blood, other than predeposited blood, do however play a role in limiting the need for transfusion of allogeneic blood. This survey of autologous blood transfusion practices, promoted by the Italian Society of ...
Kang Yunqing Y Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA - - 2014
Vascularization of three-dimensional large synthetic grafts for tissue regeneration remains a significant challenge. Here we demonstrate an electrochemical approach, named as cell electrochemical detachment (CED) technique,to form an integral endothelium and use it to prevascularize a collagen-β-tricalcium phosphate (β-TCP) graft. The CED technique electrochemically detached an integral endothelium from a ...
Butruk-Raszeja Beata B Laboratory of Biomedical Engineering, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland - - 2014
The aim of the present work was to develop simple modification technique for polyurethanes (PUs) intended for use in blood-contacting implants (vascular grafts, heart prosthesis, ventricular assist devices). PU surface was modified with soybean-derived phosphatidylcholine (PC) via one-step dip coating technique. In order to evaluate blood compatibility of the obtained ...
Haselwood Brittney A BA School of Biological and Health Systems Engineering, Arizona State University, 550 E. Orange St., Tempe, AZ 85287, - - 2014
As awareness of traumatic brain injury (TBI) increases, the need to detect mild forms and distinguish between the different severities of TBI becomes more apparent. The goal of this work is to develop a point-of-care sensor to detect whole blood biomarkers for rapid and sensitive diagnosis of TBI severity. Presented ...
Pedersen Mads Møller MM Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: - - 2014
Abnormal blood flow is usually assessed using spectral Doppler estimation of the peak systolic velocity. The technique, however, only estimates the axial velocity component, and therefore the complexity of blood flow remains hidden in conventional ultrasound examinations. With the vector ultrasound technique transverse oscillation the blood velocities of both the ...
Krieger Steffen N SN Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Monash Biomedical Imaging, Monash University, Melbourne, - - 2014
Yang et al. proposed an MRI technique for the simultaneous acquisition of cerebral blood volume (CBV), cerebral blood flow (CBF), and blood oxygenation level-dependent (BOLD)-weighted MRI signals (9). The purpose of this study was to develop modified version of the Yang sequence, which utilizes the advantages of 7 Tesla, leading ...
Benedik Penelope S PS Division of Nurse Anesthesia, Department of Acute and Continuing Care, University of Texas Health Science Center at Houston, 6901 Bertner, SON 682, Houston, TX 77030, USA. Electronic address: - - 2014
This article describes promising emerging technologies developed for measuring tissue-level oxygenation or perfusion, each with its own inherent limitations. The end user must understand what the instrument measures and how to interpret the readings. Optical monitoring using near-infrared spectrometry, Doppler shift, and videomicroscopy are discussed in terms of their application ...
Lee Sang Joon SJ Center for Biofluid and Biomimic Research, Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of - - 2014
X-ray imaging techniques have been employed to visualize various biofluid flow phenomena in a non-destructive manner. X-ray particle image velocimetry (PIV) was developed to measure velocity fields of blood flows to obtain hemodynamic information. A time-resolved X-ray PIV technique that is capable of measuring the velocity fields of blood flows ...
Sahimin N N Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, - - 2014
The quantitative buffy coat (QBC) technique and conventional Giemsa thin blood smear was compared to determine the sensitivity and specificity of the technique in detecting blood parasitic infection of the rodent populations from four urban cities in Peninsular Malaysia. A total of 432 blood samples from four rat species (Rattus ...
Liang Xiaoyun X Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, - - 2014
Arterial Spin Labeling (ASL) is an MRI technique to measure cerebral blood flow directly and noninvasively, and thus provides a more direct quantitative correlate of neural activity than blood-oxygen-level-dependent fMRI. A 3D gradient and spin-echo (GRASE) sequence is capable of enhancing signal-to-noise ratio, and has been shown to be a ...
Liu Zhugong Z Division of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD. Electronic address: - - 2014
Several high-throughput multiplex blood group molecular typing platforms have been developed to predict blood group antigen phenotypes. These molecular systems support extended donor/patient matching by detecting commonly encountered blood group polymorphisms as well as rare alleles that determine the expression of blood group antigens. Extended molecular typing of a large ...
Yalcin Huseyin C HC Mechanical Engineering Department, Dogus University, Kadikoy, 34722 İstanbul, Turkey - - 2014
During cardiogenesis, congenital heart defects (CHDs), generally start as local tissue abnormalities without underlying genetic causes, suggesting abnormal hemodynamics may be an important source. Due to the scarcity of experimental techniques that permits the formation of minimally-invasive and well-controlled cardiac perturbations, experimental investigation of embryonic development of CHD via in-vivo ...
Dong Weisheng - - 2014
Designing an appropriate regularizer is of great importance for accurate optical flow estimation. Recent works exploiting the nonlocal similarity and the sparsity of the motion field have led to promising flow estimation results. In this paper we propose to unify these two powerful priors. To this end, we propose an ...
Myers Rebecca M RM Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (United Kingdom), Fax: (+44) 1223 - - 2014
Flow chemistry and continuous processing techniques are beginning to have a profound impact on the production of functional materials ranging from quantum dots, nanoparticles and metal organic frameworks to polymers and dyes. These techniques provide robust procedures which not only enable accurate control of the product material's properties but they ...
Salazar Jose H JH Department of Surgery, Johns Hopkins School of Medicine, Baltimore, - - 2014
Previous models of support for premature sheep fetuses have consisted of cesarean delivery followed by catheterization of umbilical or central vessels and support with extracorporeal membrane oxygenation (ECMO). The limitations of these models have been insufficient blood flow, significant fetal edema, and hemorrhage related to anticoagulation. We performed a gravid ...
Lewis Kevin M KM Baxter Healthcare Corporation, Deerfield, Illinois. Electronic address: - - 2014
Microporous Polysaccharide Hemospheres (MPH) are a new plant-derived polysaccharide powder hemostat. Previous studies investigated MPH as a replacement to nonflowable hemostatic agents of different application techniques (e.g., oxidized cellulose, collagen); therefore, the purpose of this study was to determine if MPH is a surrogate for flowable hemostatic agents of similar ...
Teplov Victor V Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70210 Kuopio, - - 2014
Blood pulsation imaging (BPI) is a non-invasive optical method based on photoplethysmography (PPG). It is used for the visualization of changes in the spatial distribution of blood in the microvascular bed. BPI specifically allows measurements of the relative phase of blood pulsations and using it we detected a novel type ...
Titov V Yu VY N. I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow, Russia, - - 2014
Generation of nitrite (NO2¯) and non-thiolate nitroso compounds in human blood during leukocyte activation mainly occurred due to destruction of NO donors in the plasma, but not due to intensifi cation of NO synthesis. We proposed a mechanism of production of nitrite and non-thiolate nitroso compounds in the blood during ...
Liu Taiming T Loma Linda - - 2014
Recent evidence from humans and rats indicates that nitrite is a vasodilator under hypoxic conditions by reacting with metal-containing proteins to produce nitric oxide (NO). We tested the hypothesis that near-physiological concentrations of nitrite would produce vasodilation in a hypoxia- and concentration-dependent manner in the hind limb of sheep. Anesthetized ...
van 't Erve Thomas J TJ Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, - - 2014
Red blood cells (RBCs) collected for transfusion deteriorate during storage. This deterioration is termed the "RBC storage lesion." There is increasing concern over the safety, therapeutic efficacy, and toxicity of transfusing longer-stored units of blood. The severity of the RBC storage lesion is dependent on storage time and varies markedly ...
Lorthioir Aurélien A 1] Department of Pharmacology, Rouen University Hospital, Rouen, France [2] Department of Nephrology, Rouen University Hospital, Rouen, - - 2014
Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calcium-induced nitric oxide release, prevented by dopamine receptor stimulation. However, the ...
Witting N N Neuromuscular Research Unit andDepartment of Neurology, Rigshospitalet, University of Copenhagen, - - 2014
Background; patients with Becker and Duchenne muscular dystrophies, (BMD and DMD) lack neuronal nitric oxide synthase (nNOS). nNOS mediates physiological sympatholysis, thus ensuring adequate blood supply to working muscle. In mice lacking dystrophin, restoration of nNOS effects by a phosphodiesterase 5 (PDE5) inhibitor (sildenafil), improves skeletal and cardiac muscle performance. ...
Hampton David A DA From the Oregon Health and Science University, Division of Trauma, Critical Care and Acute Care Surgery, Trauma Research Institute of Oregon (D.A.H., L.J.F., L.K., J.D., S.U., D.L., J.W., M.A.S.); and Portland State University (C.W.),Portland, - - 2014
Liquid preserved packed red blood cell (LPRBC) transfusions are used to treat anemia and increase end-organ perfusion. Throughout their storage duration, LPRBCs undergo biochemical and structural changes collectively known as the storage lesion. These changes adversely affect perfusion and oxygen off-loading. Cryopreserved RBCs (CPRBC) can be stored for up to ...
Cabral Pablo D PD Case Western Reserve University - - 2014
Nitric oxide (NO) regulates renal function. Luminal flow stimulates NO production in the thick ascending limb (TAL). Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells. We hypothesized that TRPV4 mediates flow-induced NO production in the rat TAL. We measured ...
Grau Marijke M Institute of Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, - - 2014
During storage, red blood cells (RBC) become more susceptible to hemolysis and it has also been shown that RBC deformability, which is influenced by RBC nitric oxide synthase (RBC-NOS) activity, decreases during blood storage while a correlation between these two parameters under storage conditions has not been investigated so far. ...
Freed Julie K JK From the Departments of Anesthesiology (J.K.F), Medicine-Cardiovascular Center (A.M.B., J.C.H., D.D.G.), and Plastic Surgery (J.A.L.), Medical College of Wisconsin, Milwaukee; and VA Medical Center, Milwaukee, WI - - 2014
Mitochondrial-derived hydrogen peroxide (H2O2) regulates flow-induced dilation (FID) in microvessels from patients with coronary artery disease. The relationship between ceramide, an independent risk factor for coronary artery disease and a known inducer of mitochondrial reactive oxygen species, and FID is unknown. We examined the hypothesis that exogenous ceramide induces a ...
Markos F F Department of Physiology, University College Cork, Cork, Ireland. - - 2014
Elevated levels of insulin have been reported to induce both an arterial vasodilation mediated by nitric oxide (NO), and vasoconstriction mediated by endothelin and reactive oxygen radicals. Metformin, used to control blood glucose levels in type 2 diabetes, has also been shown to cause NO-mediated dilation of conduit arteries. It ...
Del Pozzi Andrew Thomas AT New York Medical - - 2014
Cognitive deficits are characteristic of postural tachycardia syndrome (POTS). Intact nitrergic nitric oxide (NO) is important to cerebral blood flow (CBF) regulation, to neurovascular coupling, and to cognitive efficacy. POTS patients often experience defective (NO) mediated vasodilation caused by oxidative stress. We previously showed dilation of the middle cerebral artery ...
Carvalho Leonardo José de Moura LJ Laboratório de Pesquisas em Malária, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, - - 2014
Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised ...
Johnson Paula K PK Department of Exercise Sciences, Brigham Young University, Provo, UT, USA - - 2014
Background: Vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (DSPN). Reactive oxygen species reduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced circulation and nerve ischemia. Increases in blood NO concentrations and circulation have been attributed to ...
Oliver Janine L JL Department of Urology, University of Virginia, Charlottesville, VA, - - 2014
During female sexual arousal, clitoral blood flow is controlled by endothelial nitric oxide synthase (eNOS) and its product, nitric oxide (NO). The mechanisms regulating eNOS activity and NO bioavailability in the clitoris are largely unknown. To identify proteins involved in regulation of eNOS activity within the clitoris and to evaluate ...
Simmonds Michael J MJ Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland, - - 2014
Since the identification of the elusive endothelium-derived relaxing factor as nitric oxide (NO), much attention has been devoted to understanding its physiological effects. NO is a free radical with many roles, and owing to its neutral charge and high diffusion capacity, it appears NO is involved in every mammalian biological ...
Butcher Joshua T JT Robert M. Berne Cardiovascular Research Center, University of Virginia School of - - 2014
Hemoglobin has been studied and well characterized in red blood cells for over one hundred years. However, new work has indicated that the hemoglobin alpha subunit (Hbα) is also found within the blood vessel wall, where it appears to localize at the myoendothelial junction (MEJ) and plays a role in ...
Rotiroti Marco - - 2014
An analysis of 70 wells that tap groundwater from depths of up to 260 m in and around the town of Cremona, N. Italy, show that 50 of them contain more than 10 µg/L of arsenic. Concentrations of As >10 ppb are accompanied by concentrations of Fe ranging from <0.1 ...
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