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Benedik Penelope S PS Division of Nurse Anesthesia, Department of Acute and Continuing Care, University of Texas Health Science Center at Houston, 6901 Bertner, SON 682, Houston, TX 77030, USA. Electronic address: - - 2014
This article describes promising emerging technologies developed for measuring tissue-level oxygenation or perfusion, each with its own inherent limitations. The end user must understand what the instrument measures and how to interpret the readings. Optical monitoring using near-infrared spectrometry, Doppler shift, and videomicroscopy are discussed in terms of their application ...
Liang Xiaoyun X Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, - - 2014
Arterial Spin Labeling (ASL) is an MRI technique to measure cerebral blood flow directly and noninvasively, and thus provides a more direct quantitative correlate of neural activity than blood-oxygen-level-dependent fMRI. A 3D gradient and spin-echo (GRASE) sequence is capable of enhancing signal-to-noise ratio, and has been shown to be a ...
Yalcin Huseyin C HC Mechanical Engineering Department, Dogus University, Kadikoy, 34722 ─░stanbul, Turkey - - 2014
During cardiogenesis, congenital heart defects (CHDs), generally start as local tissue abnormalities without underlying genetic causes, suggesting abnormal hemodynamics may be an important source. Due to the scarcity of experimental techniques that permits the formation of minimally-invasive and well-controlled cardiac perturbations, experimental investigation of embryonic development of CHD via in-vivo ...
Dong Weisheng - - 2014
Designing an appropriate regularizer is of great importance for accurate optical flow estimation. Recent works exploiting the nonlocal similarity and the sparsity of the motion field have led to promising flow estimation results. In this paper we propose to unify these two powerful priors. To this end, we propose an ...
Myers Rebecca M RM Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (United Kingdom), Fax: (+44) 1223 - - 2014
Flow chemistry and continuous processing techniques are beginning to have a profound impact on the production of functional materials ranging from quantum dots, nanoparticles and metal organic frameworks to polymers and dyes. These techniques provide robust procedures which not only enable accurate control of the product material's properties but they ...
Titov V Yu VY N. I. Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, Moscow, Russia, - - 2014
Generation of nitrite (NO2¯) and non-thiolate nitroso compounds in human blood during leukocyte activation mainly occurred due to destruction of NO donors in the plasma, but not due to intensifi cation of NO synthesis. We proposed a mechanism of production of nitrite and non-thiolate nitroso compounds in the blood during ...
Liu Taiming T Loma Linda - - 2014
Recent evidence from humans and rats indicates that nitrite is a vasodilator under hypoxic conditions by reacting with metal-containing proteins to produce nitric oxide (NO). We tested the hypothesis that near-physiological concentrations of nitrite would produce vasodilation in a hypoxia- and concentration-dependent manner in the hind limb of sheep. Anesthetized ...
van 't Erve Thomas J TJ Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA - - 2014
Red blood cells (RBCs) collected for transfusion deteriorate during storage. This deterioration is termed the "RBC storage lesion". There is increasing concern over the safety, therapeutic efficacy, and toxicity of transfusing longer-stored units of blood. The severity of the RBC storage lesion is dependent on storage-time and varies markedly between ...
Lorthioir Aurélien A 1] Department of Pharmacology, Rouen University Hospital, Rouen, France [2] Department of Nephrology, Rouen University Hospital, Rouen, - - 2014
Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calcium-induced nitric oxide release, prevented by dopamine receptor stimulation. However, the ...
Witting N N Neuromuscular Research Unit andDepartment of Neurology, Rigshospitalet, University of Copenhagen, - - 2014
Background; patients with Becker and Duchenne muscular dystrophies, (BMD and DMD) lack neuronal nitric oxide synthase (nNOS). nNOS mediates physiological sympatholysis, thus ensuring adequate blood supply to working muscle. In mice lacking dystrophin, restoration of nNOS effects by a phosphodiesterase 5 (PDE5) inhibitor (sildenafil), improves skeletal and cardiac muscle performance. ...
Hampton David A DA From the Oregon Health and Science University, Division of Trauma, Critical Care and Acute Care Surgery, Trauma Research Institute of Oregon (D.A.H., L.J.F., L.K., J.D., S.U., D.L., J.W., M.A.S.); and Portland State University (C.W.),Portland, - - 2014
Liquid preserved packed red blood cell (LPRBC) transfusions are used to treat anemia and increase end-organ perfusion. Throughout their storage duration, LPRBCs undergo biochemical and structural changes collectively known as the storage lesion. These changes adversely affect perfusion and oxygen off-loading. Cryopreserved RBCs (CPRBC) can be stored for up to ...
Cabral Pablo D PD Case Western Reserve University - - 2014
Nitric oxide (NO) regulates renal function. Luminal flow stimulates NO production in the thick ascending limb (TAL). Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells. We hypothesized that TRPV4 mediates flow-induced NO production in the rat TAL. We measured ...
Grau Marijke M Institute of Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, - - 2014
During storage, red blood cells (RBC) become more susceptible to hemolysis and it has also been shown that RBC deformability, which is influenced by RBC nitric oxide synthase (RBC-NOS) activity, decreases during blood storage while a correlation between these two parameters under storage conditions has not been investigated so far. ...
Freed Julie K JK Anesthesiology, Medical College of - - 2014
Rationale: Mitochondrial-derived hydrogen peroxide (H2O2) regulates flow-induced dilation (FID) in microvessels from patients with coronary artery disease (CAD). The relationship between ceramide, an independent risk factor for CAD and a known inducer of mitochondrial reactive oxygen species (ROS), and FID is unknown. Objective: We examined the hypothesis that exogenous ceramide ...
Markos F F Department of Physiology, University College Cork, Cork, Ireland. - - 2014
Elevated levels of insulin have been reported to induce both an arterial vasodilation mediated by nitric oxide (NO), and vasoconstriction mediated by endothelin and reactive oxygen radicals. Metformin, used to control blood glucose levels in type 2 diabetes, has also been shown to cause NO-mediated dilation of conduit arteries. It ...
Del Pozzi Andrew Thomas AT New York Medical - - 2014
Cognitive deficits are characteristic of postural tachycardia syndrome (POTS). Intact nitrergic nitric oxide (NO) is important to cerebral blood flow (CBF) regulation, to neurovascular coupling, and to cognitive efficacy. POTS patients often experience defective (NO) mediated vasodilation caused by oxidative stress. We previously showed dilation of the middle cerebral artery ...
Carvalho Leonardo José de Moura LJ Laboratório de Pesquisas em Malária, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, - - 2014
Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised ...
Johnson Paula K PK Department of Exercise Sciences, Brigham Young University, Provo, UT, USA - - 2014
Background: Vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (DSPN). Reactive oxygen species reduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced circulation and nerve ischemia. Increases in blood NO concentrations and circulation have been attributed to ...
Oliver Janine L JL Department of Urology, University of Virginia, Charlottesville, VA, - - 2014
During female sexual arousal, clitoral blood flow is controlled by endothelial nitric oxide synthase (eNOS) and its product, nitric oxide (NO). The mechanisms regulating eNOS activity and NO bioavailability in the clitoris are largely unknown. To identify proteins involved in regulation of eNOS activity within the clitoris and to evaluate ...
Simmonds Michael J MJ Heart Foundation Research Centre, Griffith Health Institute, Griffith University, Queensland, - - 2014
Since the identification of the elusive endothelium-derived relaxing factor as nitric oxide (NO), much attention has been devoted to understanding its physiological effects. NO is a free radical with many roles, and owing to its neutral charge and high diffusion capacity, it appears NO is involved in every mammalian biological ...
Butcher Joshua T JT Robert M. Berne Cardiovascular Research Center, University of Virginia School of - - 2014
Hemoglobin has been studied and well characterized in red blood cells for over one hundred years. However, new work has indicated that the hemoglobin alpha subunit (Hbα) is also found within the blood vessel wall, where it appears to localize at the myoendothelial junction (MEJ) and plays a role in ...
Rotiroti Marco - - 2014
An analysis of 70 wells that tap groundwater from depths of up to 260 m in and around the town of Cremona, N. Italy, show that 50 of them contain more than 10 µg/L of arsenic. Concentrations of As >10 ppb are accompanied by concentrations of Fe ranging from <0.1 ...
Shang Xiaofei - - 2014
Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the ...
Freidja Mohamed L - - 2014
A chronic increase in blood flow in resistance arteries is associated with increased lumen diameter (outward remodeling) and improved endothelium (NO)-mediated relaxation. Flow-mediated remodeling of resistance arteries is essential for revascularization in ischemic diseases. Nevertheless, it is impaired in 12 to 24-month old rats and in young Zucker Diabetic Fatty ...
Told Reinhard R Department of Clinical Pharmacology, Medical University of Vienna, Vienna, 1090, - - 2014
Purpose: The Age-Related Eye Disease Study 1 (AREDS1) showed that nutritional supplementation with anti-oxidants and zinc modifies the natural course of AMD. LPS induced oxidative stress diminishes the vasoconstrictor response of retinal vessels to oxygen breathing and was previously shown to be normalized by the AREDS 1 supplements. In the ...
Truong Giang T GT Loma Linda University, United - - 2014
Nitrite has been postulated to provide a reservoir for conversion to nitric oxide (NO), especially in tissues with reduced oxygen levels as in the fetus. Nitrite would thus provide local vasodilation and restore a balance between oxygen supply and need, a putative mechanism of importance especially in the brain. The ...
Faraco Giuseppe G Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, - - 2014
Adequate hydration is essential for normal brain function and dehydration induces cognitive deterioration. In addition, dehydration has emerged as a stroke risk factor. However, it is unknown whether alterations in cerebrovascular regulation are responsible for these effects. To address this issue, C57Bl/6 mice were water deprived for 24 or 48 hours ...
Slator Lois L 1 Respironics Respiratory Drug Delivery (UK) Ltd. , a business of Philips Electronics UK Limited, Chichester, West Sussex, UK - - 2014
Abstract Background: Valved holding chambers (VHCs) are accessory devices for pressurized metered dose inhalers (pMDIs). Use of a VHC may help overcome coordination issues associated with drug delivery via the pMDI alone. Previous work has established that aspects of VHC use, including the time between actuation and inhalation (inhalation delay) ...
Lin Hung Wen HW Department of Neurology, Cerebral Vascular Disease Research Laboratories, University of Miami, Miller School of Medicine, Two Story Laboratory (TSL), Medical Campus, Miami, Florida, - - 2014
We previously showed that inhibition of protein kinase C delta (PKCδ) improves brain perfusion 24 hours after asphyxial cardiac arrest (ACA) and confers neuroprotection in the cortex and CA1 region of the hippocampus 7 days after arrest. Therefore, in this study, we investigate the mechanism of action of PKCδ-mediated hypoperfusion after ...
Fang Shih-Yuan SY Department of Anesthesiology, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, - - 2014
Objective: The blood flow in the arteriovenous (AV) fistula is significantly reduced in diabetic patients. Statins are known to mediate pleiotropic effects in the vascular endothelium and attenuate inflammatory responses. This study tested the vascular protective effect of rosuvastatin in an experimental model of AV fistula. Methods: One week after ...
Lee Dong-Kil DK Korea Institute Geoscience and Mineral Resources (KIGAM), 92 Gwahang-no, Yuseong-gu, Daejeon 305-325, South Korea. Electronic address: - - 2014
A numerical flow analysis for the design of an oxidation pond was conducted to investigate the optimal flow characteristics. This analysis includes the inflow rate and the shape and depth of the oxidation pond. The total area and maximum depth of the pond were 500 m(2) and 3 m, respectively. We defined ...
Liu Chen C Department of Physics, Wake Forest University, Winston-Salem, NC 27109, - - 2014
The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a spherical one, decreased mean corpuscular hemoglobin concentration, varied mean corpuscular volume, reduced integrity of the erythrocyte membrane with formation of microparticles, and ...
de Matthaeis Angela A Division of Internal Medicine and Chronobiology Unit, Foggia, - - 2014
Blood acid-base imbalance has important effects on vascular reactivity, which can be related to nitric oxide (NO) concentration and increased during hypercapnia. Release of NO seems to be linked to H(+) and CO2 concentration and to exacerbation of chronic obstructive pulmonary disease (COPD), a common medical condition in the elderly. ...
Rogers Natasha M NM Department of Medicine, Vascular Medicine Institute, University of Pittsburgh School of Medicine Pittsburgh, PA, - - 2014
Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for acute heart failure and pulmonary hypertension. Here we review molecular mechanisms that ...
Zheng Ruibin R Departments of Radiology, First Affiliated Hospital of China Medical University, 155 Nanjing N St, Shenyang, 110001, Liaoning Province, People's Republic of - - 2013
Vasospasm of both large and small parenchymal arteries may contribute to the occurrence of delayed ischemic neurological deficits, and nitric oxide(NO) is an important mediators in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH). We used a rabbit two-hemorrhage model to investigate changes in plasma NO after SAH, and ...
Naylor Louise H LH School of Sport Science, Exercise and Health, The University of Western Australia, M408, 35 Stirling Highway, Crawley, WA, 6009, Australia, - - 2013
We assessed the impact of an acute bout of hyperglycaemia on nitric oxide (NO)-mediated microvascular function in the skin of adolescents with type 1 diabetes (T1DM). Twelve subjects (12-18 years) with T1DM were randomised into a control (n = 6) or hyperglycaemia (n = 6) group. Hyperinsulinaemic clamps were used to manipulate blood glucose level ...
Aamand Rasmus R 1Center of Functionally Integrative Neuroscience, Aarhus - - 2013
The carbonic anhydrase (CA) inhibitor acetazolamide (AZ) is used routinely to estimate cerebrovascular reserve capacity in patients, as it reliably increases cerebral blood flow (CBF). However, the mechanism by which AZ accomplishes this CBF increase is not entirely understood. We recently discovered that CA can produce nitric oxide (NO) from ...
Chen Yingjie - - 2013
Following coronary artery occlusion growth of collateral vessels can provide an effective blood supply to the dependent myocardium. The ischemia which results in growth of collateral vessels recruits an inflammatory response with expression of cytokines and growth factors, upregulation of eNOS in vascular endothelial cells, and expression of iNOS in ...
Zecher Daniel - - 2013
Transfusion of aged blood has been associated with increased morbidity and mortality in critically ill patients. During storage, erythrocytes release increasing numbers of microvesicles (red blood cell-derived microvesicles [RBC-MVs]). We hypothesized that RBC-MVs mediate some of the deleterious effects of aged blood transfusions. We established a murine transfusion model using ...
Wang Yimeng - - 2013
The most recent American Association of Blood Banks survey found that 40 000 units of blood are required daily for general medicine, hematology/oncology, surgery, and for accident and trauma victims. While blood transfusions are an extremely important component of critical healthcare, complications associated with transfusion of blood components still exist. It ...
Rho Junsung - - 2013
During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their potential value as a quality metric for blood products. The lack of sensitive, standardized MV assays, however, poses a significant ...
Xu Huiyun - - 2013
As a mechano-calcium channel, polycystin2 (PC2) play an important role in the response of renal epithelial cells to fluid flow shear stress. In bone tissue, osteocytes are well known as the main mechanosensory cells, and sensitive to fluid flow stimulus in vitro. In the study, we investigated the effects of ...
Grochot-Przeczek Anna - - 2013
Aims: Heme oxygenase-1 (HO-1) is a cytoprotective enzyme, which can be downregulated in diabetes. Its importance for mature endothelium has been described, but a role in proangiogenic progenitors is not well known. We investigated the effect of HO-1 on angiogenic potential of bone marrow-derived cells (BMDCs) and on blood flow ...
Cho Shinho - - 2013
Indium oxide thin films are deposited on glass substrates at nitrogen flow rates of 0-50% by rf reactive magnetron sputtering and are characterized for their structural, morphological, electrical, and optical properties. The experimental results showed that the control of nitrogen flow rate has a significant effect on the properties of ...
Golub Aleksander S - - 2013
An adequate supply of oxygen (O2) and nutrients is critical for normal organ function. The regulation of local blood flow in organs ensures matching the delivery of materials with the rate of their consumption in tissues. The mechanism by which this happens is thought to operate according to the metabolic ...
Napoli Raffaele - - 2013
To clarify whether the vasoconstrictory response is impaired and to study vascular function in patients with migraine during the headache attack. We studied vascular reactivity in the resistance arteries by using the forearm perfusion technique associated with plethysmography. We measured forearm blood flow by strain-gauge plethysmography during intra-brachial infusion of ...
Venturelli Massimo - - 2013
A spinal cord injury (SCI) clearly results in greater cardiovascular risk, however, accompanying changes in peripheral vascular structure below the lesion, mean the real impact of a SCI on vascular function is unclear. Therefore, utilizing passive leg movement-induced (PLM) hyperemia, an index of nitric oxide (NO)-dependent vascular function, and the ...
Han Sang Myung - - 2013
Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or may not be associated with detectable brain lesions. We examined mediators of long-term potentiation after SAH in rats to determine what processes might be involved. There was a reduction in synapses in the dendritic ...
Dinesh O Chandani - - 2013
Arginine is an indispensable amino acid in neonates; de novo synthesis of arginine occurs in the small intestine (SI) but is reduced during parenteral nutrition (PN), limiting the arginine available to the mucosa. We assessed the effects of route of intake and dietary concentration of arginine on protein synthesis, superior ...
Yang Jiangning J Divison of Cardiology, Department of Medicine, and Divison of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, - - 2013
The theory that red blood cells (RBCs) generate and release nitric oxide (NO)-like bioactivity has gained considerable interest. However, it remains unclear whether it can be produced by endothelial NO synthase (eNOS), which is present in RBCs, and whether NO can escape scavenging by hemoglobin. The aim of this study ...
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