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Tabesh Hadi H Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran; Institute of Physiology, RWTH Aachen University, Aachen, - - 2014
Blood oxygenation is the main performance characteristic of capillary membrane oxygenators (CMOs). Handling of natural blood in in vitro investigations of CMOs is quite complex and time-consuming. Since the conventional blood analog fluids (e.g. water/glycerol) lack a substance with an affinity to capture oxygen comparable to hemoglobin's affinity, in this ...
Guo L L Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, People's Republic of - - 2014
Patients frequently experience a loss of salivary function following irradiation (IR) for the treatment of an oral cavity and oropharyngeal cancer. Herein, we tested if transfer of fibroblast growth factor-2 (FGF2) cDNA could limit salivary dysfunction after fractionated IR (7.5 or 9 Gy for 5 consecutive days to one parotid gland) ...
Weltman Joel G JG Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, NY, - - 2014
To evaluate the influence of major cross-match on transfusion efficacy based on the change in PCV following packed red blood cell (pRBC) administration in cats. Retrospective study from January 2000 to December 2010. University Teaching Hospital. Two hundred nine cats received 233 type-specific pRBC transfusions as treatment for anemia. Forty-three ...
Ocwieja Magdalena M Novartis Pharma AG, Basel, - - 2014
Fingolimod, a sphingosine 1-phosphate receptor modulator, is the first oral disease modifying therapy approved for the treatment of relapsing multiple sclerosis. The aim of this double-blind, placebo-controlled study was to evaluate the effect of fingolimod on cerebral blood flow, platelet function, and macular thickness in healthy volunteers. The study included ...
McGuire Timothy R - - 2014
Aims: The aims of this study were to determine a mechanism and general timeline forstatin related anti-inflammatory activity. Methods: Healthy male subjects received rosuvastatin (20 mg daily) for 3 weeks. Blood samples before and after treatment were collected forclinical laboratories and research procedures.Toll-like receptor-4 (tlr-4) expression on blood monocytes was ...
Lundin Evelyn Serreyn ES Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Obstetrics and Gynecology, County Council of Östergötland, - - 2014
To determine whether a single dose tranexamic acid given intravenously immediately before surgery for presumed advanced ovarian cancer reduces perioperative blood loss and blood transfusions. Design A randomized double-blind, placebo controlled multicenter study. Two university and two central hospitals in the south-east health region of Sweden. One hundred women with ...
Adams Cynthia R CR Biologic Resources Laboratory, University of Illinois at Chicago, Chicago, Illinois, USA. - - 2014
This study was designed to evaluate the maximal amount of blood that can be safely collected in healthy, adult male and female cynomolgus macaques for 4 consecutive weeks with minimal effect on animal wellbeing. General guidelines for blood collection volumes in laboratory animals are not species-specific, and currently there are ...
Marks Denese C DC the Australian Red Cross Blood Service, Sydney, - - 2014
Blood donation is known to contribute to iron deficiency in regular blood donors. This study investigated the safety and efficacy of postdonation iron replacement to mitigate iron deficiency in blood donors. A total of 282 female whole blood donors aged 18 to 45 were prospectively randomized in a double-blinded placebo ...
Bisschops Laurens L A - - 2013
To determine blood viscosity in adult comatose patients treated with mild therapeutic hypothermia after cardiac arrest and to assess the relation between blood viscosity, cerebral blood flow, and cerebral oxygen extraction. Observational study. Tertiary care university hospital. Ten comatose patients with return of spontaneous circulation after out-of-hospital cardiac arrest. Treatment ...
Smit Kevin M - - 2013
Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and ...
Seetohul L Nitin - - 2013
The new designer drug 5-(2-aminopropyl)indole (5-IT) is an indole derivative with stimulant properties. Its synthesis was first described by Albert Hofmann and Franz Troxler in 1962. We report four deaths associated with 5-IT and a validated high-performance liquid chromatography method for quantitation of the drug. In all four deaths, an ...
Biswas Jhuma - - 2013
To investigate whether use of preoperative misoprostol can reduce blood loss during total abdominal hysterectomy (TAH). In a randomized double-blind placebo-controlled trial at a tertiary care hospital in Kolkata, India, between March 2011 and April 2012, women (n=132) undergoing TAH with or without bilateral salpingo-oophorectomy for symptomatic myomas were randomly ...
van Beekhuizen Heleen J - - 2013
To evaluate the efficacy and safety of misoprostol among patients with retained placenta in a low-resource setting. A prospective, multicenter, randomized, double-blind, placebo-controlled trial was carried out in Tanzania between April 2008 and November 2011. It included patients who delivered at a gestational age of 28weeks or more and had ...
Li C T - - 2013
Abstract Context: Chemical compositions of three herbal plants from the family Araliaceae genus Panax [Panax ginseng C. A. Mey, P. quinquefolius L. and P. notoginseng (Burk.) F. H. Chen] are quite similar; however, their medicinal natures vary greatly. The reason for differences has been explained in traditional Chinese medicine theory ...
Wong Rachel H X - - 2013
BACKGROUND:: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition. OBJECTIVES:: To evaluate the effects of chronic resveratrol supplementation on both ...
Scheidweiler Karl B KB Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, - - 2013
Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples. Low and high blood and plasma pools were created for each of 10 participants after they smoked a cannabis cigarette. The stabilities of Δ(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol ...
Bergamaschi Mateus M MM Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, - - 2013
Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents. Some "per se" laws make it illegal to drive with any amount of drug in the body, while others establish blood, saliva, or urine concentrations above which it is illegal to drive. The persistence of ...
Kang Jaehui - - 2013
To examine the efficacy of Korean red ginseng for improving blood flow in healthy people. Participants were randomized and treated with 1500 mg of Korean red ginseng extract or placebo for 8 weeks. The effect of Korean red ginseng was evaluated by digital infrared thermal images, and Doppler sonography, and ...
Ismail Alaa - - 2013
A 66-year-old man returned to the UK from Thailand with a 2-week history of new confusion, hallucinations, fever with rigours and productive cough. He had not responded to (unspecified) antibiotic treatment in Thailand. On examination he was afebrile, with an abbreviated mental test score of 8/10 and no other findings ...
Wong Rachel H X - - 2013
: Heart health benefits have been attributed to regular consumption of oats. Preclinical evidence suggests that a wild green oat extract (WGOE) may improve vasodilator function, but this is yet to be evaluated in humans. : To determine whether regular daily consumption of WGOE can influence vasodilator function in systemic ...
Salles Alvaro Wagner Rodrigues AW Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, Avenida Professor Lineu Prestes 2242, 05508-000 São Paulo, SP, - - 2013
Objective. The purpose of this study was to examine alterations in blood-flow signals (BFS) from human teeth during an alignment and leveling phase (superelastic wire 0.014'') in a clinical orthodontic treatment using laser doppler flowmetry (LDF). Materials and Methods. Recordings were made in 12 maxillary left central incisors. The basal ...
Choo S P - - 2013
Preclinical studies have demonstrated the additive effect of rapamycin with bevacizumab for hepatocellular carcinoma treatment. We conducted a Phase 1 study to evaluate the safety and pharmacokinetics of the combination in patients with hepatocellular carcinoma. Adult participants with advanced hepatocellular carcinoma received intravenous bevacizumab (5mg/kg every 14 days) and oral ...
Schmidl Doreen - - 2012
BACKGROUND: To investigate the effect of orally administered moxaverine (Kollateral forte®) on ocular blood flow in young healthy subjects. METHODS: Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crossover study. Volunteers received 900 mg moxaverine-hydrochloride administered orally in three equal doses ...
Yano Shoji - - 2012
OBJECTIVE: To determine whether levels of melatonin in blood and urine can serve as a peripheral biomarker to reflect brain serotonin synthesis in individuals with phenylketonuria (PKU). STUDY DESIGN: We measured the levels of melatonin, a serotonin metabolite in the pinealocytes, in the blood and urine of individuals with PKU ...
Rodhe Ylva - - 2012
OBJECTIVE: Chronic kidney disease is associated with inflammation, oxidative stress, malnutrition, poor oral health, and mouth dryness. The objective of this study was to evaluate effects of sea buckthorn oil (SBO) extract, which is rich in vitamins, phytochemicals, and polyunsaturated fatty acids, on oxidative stress, saliva production, and inflammation in ...
Wei Ming-Qing - - 2012
Vascular dementia (VaD) is the second common subtype of dementia after Alzheimer's disease. However, there is still a lack of medication that demonstrates clinically relevant symptomatic improvement. Static blood obstructing the brain is the main Chinese medicine syndrome of VaD. To evaluate the effects of Chinese medicine for promoting blood ...
Salem A - - 2012
Bionomic aspects of Stomoxys calcitrans (Linnaeus, 1758) (Diptera: Muscidae) were studied under laboratory conditions. For this reason, laboratory-rearing techniques were optimized at the National Veterinary School of Toulouse. The colony was maintained at 25±2°C, 50±10% RH under a 12-hour light cycle and observed daily. The size of each adult cage ...
Carlsson Cynthia M - - 2012
Hypercholesterolemia in midlife increases risk for Alzheimer's disease (AD) and contributes to cerebrovascular dysregulation - an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD. In a randomized, controlled, double-blind pilot ...
Aucar John A - - 2012
BACKGROUND: The storage lesion of packed red blood cells (PRBCs) consists of biochemical changes associated with increased inflammatory mediators and decreased oxygen-carrying capacity. The effect of storage on the coagulation system is less well studied. The purpose of this study is to determine how PRBC storage time affects the activated ...
Seishi Yasuhisa - - 2012
ABSTRACT: The hemoglobin vesicle (Hb-vesicle) is a cellular-type artificial oxygen carrier showing a resuscitative effect comparable to that of blood transfusion in several animal models. However, the efficacy of Hb-vesicles for resuscitation when the hemorrhage cannot be controlled remains unclear. Therefore, we used Hb-vesicles in a rat hemorrhagic shock model ...
Askar M A - - 2012
In contrast to air travel, there are no recommendations on tracing ground transport passengers exposed to infectious pathogens. We analysed European statistics on passenger transport in different conveyances and conducted expert workshops to discuss environmental conditions in ground transport, indications and minimal datasets required for contact tracing. Transport performance in ...
Hashimoto Yuki - - 2012
The precise mechanism causing outer retinal damage in acute macular neuroretinopathy (AMN) remains unclear. In this study, choroidal blood flow velocity was quantitatively evaluated using laser speckle flowgraphy (LSFG) in a patient with AMN who received systemic corticosteroid therapy. Corticosteroids were systemically administrated across 4 months for an AMN patient. ...
Järv Olle - - 2012
Excessive land use and suburbanisation around densely populated urban areas has gone hand in hand with a growth in overall transportation and discussions about causality of traffic congestions. The objective of this paper is to gain new insight regarding the composition of traffic flows, and to reveal how and to ...
Wang Dong D Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892, USA. - - 2012
Blood for transfusion is stored for up to 42 days. Older blood develops lesions and accumulates potentially injurious substances. Some studies report increasing toxicity as blood ages. We assessed the safety of transfused older versus newer stored blood. PubMed, Scopus, and Embase were searched using terms new and old and ...
Trahair Laurence G - - 2011
Postprandial hypotension leading to increased morbidity, and mortality, is an important clinical problem, particularly in the elderly and individuals with autonomic dysfunction. The magnitude of the postprandial fall in blood pressure (BP) appears to be dependent on the rate of nutrient entry into the small intestine and may be related ...
Ahmad Nisar - - 2011
The main objective of the current study is to investigate the potential of Carica papaya leaves extracts against Dengue fever in 45 year old patient bitten by carrier mosquitoes. For the treatment of Dengue fever the extract was prepared in water. 25 mL of aqueous extract of C. papaya leaves ...
Patterson Stephen D - - 2011
The response of calf-muscle strength, resting blood flow, and postocclusive blood flow (PObf) were investigated after 4 wk of low-load resistance training (LLRT) with and without blood-flow restriction in a matched-leg design. Ten untrained older individuals age 62-73 yr performed unilateral plantar-flexion LLRT at 25% 1-repetition maximum (1RM). One limb ...
Mousavi F - - 2011
Background: The increase in demand for blood products because of new surgical and medical procedures seeks more research to find new ways to recruit people to donate blood. Objective/Aim: To determine the level of people's knowledge about donating blood considering its relation with infectious and chronic diseases, drug abuse, unsafe ...
Chang Ke-Vin - - 2011
PURPOSE: To assess sympathetic vasomotor activity and its changes with age, using pulsed wave Doppler ultrasound. METHODS: We recruited 20 young adults (24-37 years old) and 20 older individuals (60-81 years old). Pulsed wave Doppler ultrasound was applied over the right radial artery to measure blood flow at rest and ...
Gentilcore Diana - - 2011
BACKGROUND: Postprandial hypotension is an important problem in the elderly and may be triggered by the increase in splanchnic blood flow induced by a meal. Acarbose attenuates the fall in blood pressure (BP) induced by oral sucrose and may be useful in the management of postprandial hypotension. It is not ...
Žilinskas Juozas - - 2011
The anti-inflammatory effects of a homeopathic remedy, Traumeel S, have been observed in experimental and clinical studies; however, its antioxidant properties have not been elucidated. The aim of the present study was to evaluate the antioxidant effects of Traumeel S on peripheral blood neutrophils in patients with periodontitis. The study ...
Costantini David - - 2011
Integration is a property of biological systems that refers to the extent to which their components are correlated through functional, structural, developmental or evolutionary interdependency. This study examined patterns of functional integration among different molecular components of the blood redox system (both plasma and red blood cells) in zebra finches ...
Khan Haroon - - 2011
Silver Nitrate (AgNo(3)) effect on the status of reduced glutathione (GSH), the major non-protein thiol in blood components were examined using freshly isolated plasma and cytosolic fraction of whole blood of healthy human volunteer. AgNo(3) had significant effects on GSH contents reduction in plasma and cytosolic fraction of blood. Effect ...
Reynolds James D - - 2011
Protein S-nitrosylation (the binding of a nitric oxide [NO] group to a cysteine thiol) is a major mechanism through which the ubiquitous cellular influence of NO is exerted. Disruption of S-nitrosylation is associated with a wide range of pathophysiologic conditions. Hemoglobin (Hb) exemplifies both of these concepts. It is the ...
Stokes Alan H - - 2011
Dried bloodspot (DBS) technology has been available for many decades but only in the last five years has it been considered for routine bioanalysis of blood samples collected on preclinical and clinical studies as part of a drug development programme. Advantages of using DBS versus typical plasma samples include smaller ...
Kücükakin Bülent - - 2011
Abstract Background. Transfusion of blood components may increase the risk of complications in relation to surgery. During storage, red blood cells (RBCs) undergo structural and functional changes that may reduce function and viability after transfusion. The aim of the study was to evaluate the quality of buffy-coat reduced red cells ...
Ginsburg Isaac - - 2011
Measuring plasma antioxidant activity probably underestimates the oxidant-scavenging ability of blood in vivo because the contribution of circulating cells, which are also capable of clearing reactive oxygen species, is not taken into account.
Rinalducci Sara - - 2011
BACKGROUND: Several researches on aging red blood cells (RBCs)-performed both in vivo and under blood bank conditions-revealed that RBC membrane proteins undergo a number of irreversible alterations, mainly due to oxidative stress. The individuation of proteins to be used as indicators of irreversible RBC injury and to be proposed as ...
Khan Haroon - - 2011
Aluminium is being used in the medicines in the form of antacids. The Aluminium metal can be leached from our utensils and can harm the body for its side effects, if become available to the systemic circulation. So it is important to check the effect of Aluminum on the Glutathione ...
Hong Juliana - - 2011
Similar to other developed countries, only 3% of the total population in Hong Kong donate blood (Hong Kong Red Cross Blood Transfusion Service 2003). More than 20% of annual donations come from youngsters aged 18-25. However, this category of donors has decreased gradually from 24.6% in 2004 to 22.9% in ...
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