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Huang Zhonghui Z New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, - - 2014
The improvements in the flow and packing of fine pharmaceutical powder blends due to dry coating of micronized acetaminophen (mAPAP, ∼11μm), a model poorly flowing drug, are quantified. Poor flow and packing density of fine excipients (∼20μm) allowed testing the hypothesis that dry coating of cohesive API may counteract poor ...
Engdahl Nicholas B NB Department of Civil and Environmental Engineering, Washington State University, Pullman, Washington 99164, - - 2014
The ability for reactive constituents to mix is often the key limiting factor for the completion of reactions across a huge range of scales in a variety of media. In flowing systems, deformation and shear enhance mixing by bringing constituents into closer proximity, thus increasing reaction potential. Accurately quantifying this ...
Omodaka Shunsuke S Department of Neurosurgery, Kohnan Hospital, Sendai, - - 2014
Laser speckle flowgraphy (LSFG) is a noninvasive technique that can measure relative blood flow velocity in the optic fundus. The authors present a case of symptomatic internal carotid artery occlusion treated with superficial temporal artery (STA)-middle cerebral artery (MCA) bypass in which an improvement of ocular circulation was confirmed by ...
Stothard J Russell JR Department of Parasitology,Liverpool School of Tropical Medicine,Liverpool L3 - - 2014
SUMMARY Malaria microscopy in sub-Saharan Africa is often restricted by access to light microscopes. To address this gap, a novel portable inverted monocular microscope, the Newton Nm1, was designed and is now commercially available. Its diagnostic performance was assessed in a blinded-slide trial at ×1000 (oil) of Giemsa-stained thick blood ...
Huang Fei F Department of Orthopaedics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, - - 2014
Conflicting reports have been published regarding the effectiveness and safety of aprotinin in reducing blood loss and transfusion in patients undergoing orthopedic surgery. We performed a meta-analysis to evaluate the effectiveness and safety of aprotinin in reducing blood loss and transfusion in major orthopedic surgery. MEDLINE, PubMed, EMBASE and Cochrane ...
Smith Graham A GA Department of Haematology, Barnet and Chase Farm NHS Hospitals Trust, The Ridgeway, Enfield, UK, EN2 - - 2014
Iron deficiency is a significant cause of deferral in people wishing to donate blood. If iron removed from the body through blood donation is not replaced, then donors may become iron deficient. All donors are screened at each visit for low haemoglobin (Hb) levels. However, some deferred blood donors do ...
Cao X X Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, - - 2014
Background:Previous studies supported a link between the ABO blood type and survival for several types of malignancies. Nonetheless, the relationship between ABO blood type and survival in colon cancer patients has not been rigorously evaluated. The goal of this retrospective analysis was to discern the correlations between ABO blood group ...
Treff G G Division of Sports and Rehabilitation Medicine, University of Ulm, Ulm, Germany - - - 2014
Gastrointestinal (GI) blood loss is a possible reason for anemia in athletes. To quantify the impact on endurance performance, we present data of a world-class rower who developed anemia due to GI blood loss but maintained his training volume. Eight months after recording four normal hematological values over 6 months, ...
Fontana Stefano S Regional Blood Transfusion Service of the Swiss Red Cross, - - 2014
Optimising the use of blood has become a core task of transfusion medicine. Because no general guidelines are available in Switzerland, we analysed the effects of the introduction of a guideline on red blood cell (RBC) transfusion for elective orthopaedic surgery. Prospective, multicentre, before-and-after study comparing the use of RBCs ...
Tomson Ruth R *Department of Biomedical Engineering, Technomedicum, Tallinn University of Technology, Ehitajate Rd 5, 19086, Tallinn, Estonia †Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Department of Nephrology UHL, County Council of Östergötland, Linköping, - - 2014
The aim of the study was to examine the possibility of post-dialysis urea rebound assessment utilizing UV-absorbance measurements in spent dialysate. Twenty-six patients on chronic three-times-a-week hemodialysis (HD) were studied in two separate studies. Double-beam spectrophotometer was used for the determination of UV-absorbance in the collected spent dialysate samples. Also, ...
Lieberman Lani L Department of Clinical Pathology, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, - - 2014
Despite the high utilization of blood products by pediatric oncology patients, literature in this population remains scarce. The primary objective of this study was to assess red blood cell (RBC) and platelet (PLT) utilization rates and transfusion thresholds in pediatric oncology patients. The secondary objective was to describe transfusion-related complications ...
Doria Maria M 1 Nephrology and Dialysis Unit, San Donato Policlinico, I.R.C.C.S., San Donato Milanese - - - 2014
Intradialytic hypotension (IDH) represents a common hemodialysis (HD) complication. Blood volume tracking (BVT) is a tool regulating the relative blood volume changes and potentially reducing the occurrence of IDH. The aim of this study was to evaluate the ability of BVT to reduce the staff workload associated to IDH. Ten ...
Bou Monsef Jad J Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, - - 2014
Pre-operative donation of autologous blood has been widely used in elective joint replacement procedures to avoid the risks of allogeneic blood transfusions. However, the high percentage of wasted autologous blood questions the general efficacy of pre-operative autologous blood donation (PABD) for all patients undergoing hip replacement. This study prospectively investigates ...
Kobayashi Shuzo S Department of Nephrology, Immunology and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, - - 2014
Cognitive dysfunction is prevalent in chronic kidney disease patients. Little is known about the relationship between the regional cerebral blood flow (rCBF) and cognitive function in hemodialysis (HD) patients. We used quantitative single-photon emission-computed tomography (SPECT) to determine whether rCBF decreased in these patients. Fifty-four consecutive HD patients who were ...
Hirth Richard A RA School of Public Health, Health Management & Policy, University of Michigan, Ann Arbor, MI. Electronic address: - - 2014
In 2011, Medicare implemented a prospective payment system (PPS) covering an expanded bundle of services that excluded blood transfusions. This led to concern about inappropriate substitution of transfusions for other anemia management methods. Medicare claims were used to calculate transfusion rates among dialysis patients pre- and post-PPS. Linear probability regressions ...
Loonen Anne J M AJ Jeroen Bosch Hospital, Laboratory of Molecular Diagnostics, 's-Hertogenbosch, The Netherlands ; Fontys University of Applied Sciences, Department of Medical Molecular Diagnostics, Eindhoven, The - - 2014
Molecular pathogen detection from blood is still expensive and the exact clinical value remains to be determined. The use of biomarkers may assist in preselecting patients for immediate molecular testing besides blood culture. In this study, 140 patients with ≥ 2 SIRS criteria and clinical signs of infection presenting at ...
Prodanchuk Mykola M Medved's Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health Ukraine, Kyiv, - - 2014
Accumulation of trace elements occurs in conditions of decreased kidney function. In some conditions, increased trace elements can have toxic features. On the other hand, studies are showing that concentration of some trace elements could be decreased in ERSD patients as well. The most important factor affecting trace element concentration ...
Goksu Sema Sezgin SS Department of Medical Oncology, Kayseri State Hospital of Research and Education, Kayseri, Turkey E-mail : - - 2014
Background: Treatment of anemia is an important issue in the palliative care setting. Blood transfusion is generally used for this purpose in supportive care. However the place of blood transfusion in terminally ill cancer cases is less far established. Objective: We aimed to outline the use of transfusions and to ...
Stasiolek Mariusz - - 2014
Recent reports suggested dendritic cells (DCs) to be important players in the pathogenesis of autoimmune thyroid processes in humans. However, there are virtually no data addressing the influence of thyroid autoaggression-associated disturbances of thyrometabolic conditions on DCs biology. The aim of the study was to evaluate the influence of L-thyroxine ...
Shaik Farid A W AW Universiti Sains Malaysia, School of Medical Sciences, Department of Emergency Medicine, Kubang Kerian, Kelantan 16150, - - 2013
According to the class of hypovolaemic shock, a blood loss less than 750 ml is not associated with the physiological changes. As a result it may cause a delay in fluid resuscitation. We postulate inferior vena cava (IVC) diameter reduction in inspiration and expiration may resemble the significant volume of ...
Zhou Y-B - - 2013
Evidence suggests that cesarean section is likely associated with a reduced placental transfusion and poor hematological status in neonates. However, clinical studies have reported somewhat inconsistent results. We conducted a systematic review and meta-analysis to examine whether cesarean section affects placental transfusion and iron-related hematological indices. Pubmed, Web of Science, ...
Alshryda Sattar - - 2013
Approximately one-third of patients undergoing total hip replacement surgery require one to three units of blood postoperatively. Tranexamic acid is a synthetic antifibrinolytic agent that has been successfully used intravenously to control bleeding after total hip replacement. A topical application is easy to administer, provides a maximum concentration of tranexamic ...
McQuilten Z - - 2013
To establish blood donation rates among African refugees and migrants and identify demographic and socio-economic factors that are associated with their blood donation. A cross-sectional survey of 425 migrants and refugees living in Victoria and South Australia was used to assess blood donation status. The association between blood donation and ...
Bolliger Daniel - - 2013
The value of thrombelastography (TEG) and thromboelastometry (ROTEM) to improve perioperative hemostasis is under debate. We aimed to assess the effects of TEG- or ROTEM-guided therapy in patients undergoing cardiac surgery on the use of allogeneic blood products. We analyzed 12 trials including 6835 patients, 749 of them included in ...
Godin Gaston - - 2013
Objective: This study tested key variations in the question-behavior effect against a control condition or an implementation intention condition on returning to give blood among lapsed donors (individuals who had not given blood in the past 2 years). Design: At baseline, 7,000 lapsed donors were randomized to 1 of 6 ...
Fassl Jens - - 2013
Proximal aortic surgery with hypothermic circulatory arrest (HCA) commonly involves perioperative transfusion of allogeneic blood products, including red blood cells, plasma, and platelets. The authors hypothesized that surgery with HCA could be performed without allogeneic blood products and that a thromboelastometry-guided algorithm would reduce the transfusion of allogeneic blood products. ...
Wu Shu-Hui - - 2013
Objectives: This study was designed to evaluate the effects of cord blood mononuclear cell transplantation in multiple system atrophy (MSA). Clinical Presentation and Intervention: Cord blood mononuclear cells (1-2 × 10(8) cells/6 ml) were injected into the subarachnoid space using lumbar puncture in patients 1 and 2 and cisterna magna ...
Ker K K Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. - - 2013
Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of the reduction in blood loss and how it relates to the dose of TXA is unclear. A systematic review of randomized trials was performed. Data were extracted on blood loss from trials comparing intravenous TXA with no TXA ...
Rogachev Boris - - 2013
: Previous study has demonstrated the efficacy of hemodialysis in reducing blood glutamate levels. The purpose of the present study is to investigate whether peritoneal dialysis (PD) may be effective in lowering blood glutamate levels, which may serve as a potential tool for improving neurological function after brain injury. : ...
Fox Erin E EE Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. - - 2013
In the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study, waiver of consent was used because previous literature reported low response rates and subsequent bias. The goal of this article was to examine the rationale and tradeoffs of using waiver of consent in PROMMTT. PROMMTT enrolled trauma patients receiving at ...
Osei E N - - 2013
BACKGROUND: Misuse of blood by clinicians was suggested to explain blood shortage in sub-Saharan Africa although based on little evidence. This study evaluated whether routine halving (restricted) of blood requests was justified. STUDY DESIGN AND METHODS: On alternated days for 3 months in 2011-2012, restricted or full blood product supply [whole ...
Li Zhi-Jun ZJ Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of - - 2013
The present meta-analysis aimed at assessing the effectiveness and safety of tranexamic acid (TXA) in reducing blood loss and transfusion in spinal surgery. Systematic searches of all studies published through March 2012 were identified from PubMed, EMBase, Cochrane library, Science Direct, and other databases. Only randomized controlled trials (RCTs) were ...
Chowdhury Shakila - - 2013
<b>Purpose: </b>The United Kingdom Renal Association recommends duplex ultrasound to<b> </b>monitor arteriovenous fistula (AVF) flow rates during surveillance. Significant<b> </b>flow rate changes should prompt further investigation or treatment to avoid a<b> </b>failing fistula. Hemodialysis is known to alter the hemorrheologic and physiologic factors with a potential impact on measured flow ...
Gandhi Rajiv - - 2013
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug used as a blood-sparing techniques in many surgical specialties. The principal objective of our meta-analysis was to review randomized, controlled trials (RCT) comparing total blood loss and the number of patients receiving allogeneic blood transfusions with and without the use of TXA ...
Zhou Xin-Die - - 2013
BACKGROUND: Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe and effective. We examined whether intravenous tranexamic acid, when compared with placebo, was ...
Tan Jixiang - - 2013
BACKGROUND: To evaluate the effectiveness and safety of tranexamic acid (TEA) treatment in reducing perioperative blood loss and transfusion for patients receiving primary unilateral total knee arthroplasty (TKA) and to explore the most effective and safe protocol. MATERIALS AND METHODS: This study was based on Cochrane methodology for conducting meta-analyses. ...
Zhu Yong-Sheng YS Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, - - 2013
Physical activity may influence cerebrovascular function. The objective of this study was to determine the impact of life-long aerobic exercise training on cerebral vasomotor reactivity (CVMR) to changes in end-tidal CO2 (EtCO2) in older adults. Eleven sedentary young (SY, 27±5 years), 10 sedentary elderly (SE, 72±4 years), and 11 Masters ...
Poon C M - - 2013
BACKGROUND: Maintenance of an effective pool of regular donors is important for protecting public health. In planning the development of blood donation services, motivation for repeat donation would need to be considered in context of the location of blood donation centres in the community. STUDY DESIGN AND METHODS: Donors giving ...
Fu De-Jie - - 2013
Objective: The effect of tranexamic acid (TA) on patients receiving total knee arthroplasty (TKA) has been reported in many small clinical trials. But single trials are not sufficient enough to clarify the effectiveness and safety of TA. So, we carried out a meta-analysis of randomized controlled trials to investigate the ...
Todaka Takashi - - 2013
We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in blood collected from Yusho patients during medical health examinations performed from 2004 to 2010. Out of the 242 and 200 Yusho patients who received medical health examinations in 2004 and 2010, respectively, the concentrations ...
Orme Jacquie - - 2013
To explore patients' views on living with anaemia and undergoing blood transfusions in a day hospice. This was a qualitative study using semi-structured interviews. Ten patients who between them had received 90 transfusions were purposively sampled from the hospice day unit. The interviews were digitially recorded, transcribed anonymously, and the ...
Nuttall Gregory A GA Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA. - - 2013
To determine whether the use of a computerized bar code-based blood identification system resulted in a reduction in transfusion errors or near-miss transfusion episodes. Our institution instituted a computerized bar code-based blood identification system in October 2006. After institutional review board approval, we performed a retrospective study of transfusion errors ...
Kasper David C - - 2013
Background: Conventional blood culture is still the gold standard for sepsis diagnosis but results are not immediately available and pathogens are only detected in approximately 25% of cases. New molecular assays for the detection of blood stream pathogens are promising diagnostic tools. Objectives: The aim of the study was to ...
Juskewitch Justin E JE Mayo Graduate School, Mayo Clinic, Rochester, MN, - - 2013
Sepsis biomarker research requires an infrastructure to identify septic patients efficiently and to collect and store specimens properly. We developed a novel infrastructure to study biomarkers of sepsis in children. Patients in pediatric and neonatal intensive care units were enrolled prospectively; enrollment information was stored in a secure, remotely accessible ...
Cai Kejia - - 2013
A few studies have reported that magnetization transfer (MT) -preparation interacts with blood oxygen level dependent (BOLD) contrast used for functional magnetic resonance imaging (MRI). However, the mechanism is still not well established. This study shows that blood oxygenation level itself affects MT contrast. MT ratio (MTR) decreases with increased ...
Bruley Duane F - - 2013
We have defined the Zymogen Protein C (ZPC) to Activated Protein C (APC) process as the "silver bullet" of blood anticoagulation. This definition suggests that the anticoagulation activity occurs when and where it is needed, resulting in local anticoagulation without enhanced bleeding. It is important for man to be able ...
Masakane Ikuto - - 2013
In the previous papers, we reported that predilution hemodiafiltration (HDF) has more beneficial effects on dialysis patients than postdilution HDF. The mechanism behind this has not yet been clarified, but some factors could explain the advantage, such as a well-balanced solute removal pattern, reduction in the small nutrient loss and ...
Kondo Yuko - - 2013
We used near-infrared spectroscopy (NIRS) to evaluate cerebral blood oxygenation changes in subjects undergoing cesarean section under spinal anesthesia (SP) with hyperbaric bupivacaine (group H, 27 subjects) or isobaric bupivacaine (group I, 15 subjects). In group H, total-Hb, oxy-Hb, and mean blood pressure (MBP) within 20 min after SP were ...
Vaupel Peter - - 2013
Hypoxia is a characteristic of many solid tumors, can lead to the development of an aggressive phenotype and acquired treatment resistance, and is an independent, adverse prognostic indicator. In this literature review, we show that hypoxia is also a typical feature in prostate cancer (PC), the most commonly diagnosed cancer ...
Kashiwagi Tetsuya - - 2013
Background: Hemodialysis is a treatment in which uremic toxins and excess water content are removed from the blood with a dialyzer and dialysis fluid. The efficiency of hemodialysis is strongly influenced by the following 3 parameters: the blood flow rate (QB), the dialysis fluid flow rate (QD), and the overall ...
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