Search Results
Results 301 - 350 of 1831
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Sharma Ritu - - 2012
PCR is usually performed on purified DNA. However, the extraction of DNA from whole blood is time consuming and involves the risk of contamination at every step. Hence, it is desirable to amplify DNA directly from whole blood. Earlier, investigators tried to achieve this target by either pretreatment of whole ...
Lutz H H - - 2012
BACKGROUND: Accurate quantification of liver fibrosis is essential for therapeutic decision-making and follow-up of chronic liver diseases. AIMS: To optimize the quality of non-invasive assessment of liver fibrosis in patients with chronic hepatopathy we compared Doppler ultrasound with liver histology and transient elastography (TE). METHODS: In this prospective observational study, ...
Amemiya Shiori - - 2012
The study aims to investigate the effect of cerebral ischemia or hypoperfusion in the evaluation of neural activity with blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI), and to examine whether the severity of the compromised hemodynamic status in patients with major cerebral artery diseases could, conversely, be assessed with ...
Lindholm J - - 2012
A previously healthy 60-year-old male presented with fever, general pain and a C-reactive protein (CRP) of 160 mg/L. He was prescribed doxycycline. In the emergency room three days later, he was intubated and had a saturation of 70% on 100% oxygen. The chest X-ray showed bilateral lobar pneumonia. Streptococcus pneumonia ...
Francis Richard O - - 2012
BACKGROUND: A uniform threshold strategy for converting from minipool (MP)-nucleic acid testing (NAT) to individual donation (ID)-NAT screening for acute West Nile virus (WNV) infection among blood donors is lacking. We report on WNV screening at the New York Blood Center during the 2010 seasonal WNV epidemic, the most severe ...
Cavuşoğlu Mustafa - - 2012
Most experiments assume a global transit delay time with blood flowing from the tagging region to the imaging slice in plug flow without any dispersion of the magnetization. However, because of cardiac pulsation, nonuniform cross-sectional flow profile, and complex vessel networks, the transit delay time is not a single value ...
Iwase Yoko - - 2012
INTRODUCTION: This study aimed to determine the effects of acute normovolemic hemodilution (ANH) using low-molecular-weight hydroxyethyl starch (LMW-HES) on intraoperative blood loss in patients who had received preoperative autologous blood donation (PABD) and had undergone sagittal split ramus osteotomy (SSRO). METHODS: Patients who had undergone SSRO were analyzed. All 250 ...
Crocker Matthew - - 2012
Tumor vasculature is a promising therapeutic target in glioblastoma. Imaging tumor blood flow may help assess the efficacy of anti-angiogenic treatments. We determined the clinical usefulness of stable xenon CT performed preoperatively in patients with glioblastoma. This is a prospective cohort study. We determined absolute tumor blood flow before surgery ...
Källman Ulrika - - 2012
källman u., bergstrand s., ek a.-c., engström m., lindberg l.-g. & lindgren m. (2012) Different lying positions and their effects on tissue blood flow and skin temperature in older adult patients. Journal of Advanced Nursing00(0), 000-000. doi: 10.1111/j.1365-2648.2012.06000.x ABSTRACT: Aim.  To report a study to compare the effects of different ...
Liao Lun-De - - 2012
Optical imaging of changes in total hemoglobin concentration (HbT), cerebral blood volume (CBV), and hemoglobin oxygen saturation (SO(2)) provides a means to investigate brain hemodynamic regulation. However, high-resolution transcranial imaging remains challenging. In this study, we applied a novel functional photoacoustic microscopy technique to probe the responses of single cortical ...
Matsuki Noriaki - - 2012
Microbubbles have been used in a variety of fields and have unique properties, for example shrinking collapse, long lifetime, efficient gas solubility, a negatively charged surface, and the ability to produce free radicals. In medicine, microbubbles have been used mainly as diagnostic aids to scan various organs of the body, ...
Harrison Christopher R - - 2012
Hemoglobin-based oxygen carriers (HBOCs) are blood substitutes, synthesized by polymerizing hemoglobin, which are being developed and investigated as alternatives to blood for medical purposes. However, due to their ability to increase the oxygen carrying capacity when taken by healthy individuals, HBOCs have been used as a doping agent among endurance ...
Muller Lisa I - - 2012
Physiologic monitoring is important when chemically immobilizing wildlife. Blood oxygenation is usually monitored by pulse oximetry in the field; however, there is some question whether this technique accurately reflects oxygen saturation in wild white-tailed deer (Odocoileus virginianus). We evaluated different doses of medetomidine (125, 150, 175, or 200 μg/kg) mixed ...
Gombotz Hans - - 2012
Patient Blood Management (PBM) describes an evidence-based, multidisciplinary therapeutic approach. Its focus is on the treatment of the individual patient and as such comprises transfusion therapy and pharmacotherapy. Furthermore, the applicability of PBM is not limited to the perioperative setting but is applicable also to other therapeutic measures and disciplines ...
Hansch Andreas - - 2012
OBJECTIVE: To assess the feasibility of time-resolved parallel three-dimensional magnetic resonance imaging (MRI) for quantitative analysis of pulmonary perfusion using a blood pool contrast agent. METHODS: Quantitative perfusion analysis was performed using novel software to assess pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) in ...
Chavan P D - - 2012
Microbiological contamination of blood and blood products is a well-recognised transfusion risk. This study was performed in the blood bank of our oncology centre, with an objective to detect bacterial contamination in our blood products using oxygen consumption as a surrogate marker [Pall Enhanced Bacterial Detection System (eBDS)]. Results revealed ...
Nam Kweon-Ho - - 2012
Previous studies have demonstrated that blood echogenicity is highly variable depending on blood flow velocity and pulsatility mainly due to the variation of red blood cell (RBC) aggregation. However, most of the studies were performed in a mock-flow loop using porcine blood and the results were not fully validated in ...
Song Ruibo - - 2012
The experiment was implemented to measure the multi-component blood flow velocity in elastic vascular phantoms. Poly (vinyl alcohol) cryogel, PVA-C, is presented as a tissue-mimicking material, suitable for application in ultrasound imaging. The hardness of PVA-C changed with the number of freeze-thaw cycles. Two kinds of PVA phantoms with different ...
Siewiorek Gail M - - 2012
Abstract Purpose: To compare the performance in vitro of 6 distal protection filters (DPFs) on the basis of filtration ability and effects on pressure gradient and vascular impedance in a flow model of the internal carotid artery (ICA). Methods: Six DPFs (Accunet, Angioguard, FilterWire, Gore Embolic Filter, NAV6, and SpiderFX) ...
Shen Zhi-Yong - - 2012
BACKGROUND: The purpose of this study was to investigate the relationship between blood supply detected by Doppler ultrasound and the Nottingham Prognostic Index (NPI) in breast cancer patients. PATIENTS AND METHODS: 137 patients with breast carcinoma, who had undergone color Doppler flow imaging (CDFI) and surgery, were involved in this ...
Lutz Austin - - 2012
Priapism is defined as an erection lasting greater than 4 hours. It is grouped into three subtypes: ischemic (low flow), nonischemic (high flow), and stuttering priapism. We present an interesting case and review of the conversion from a low-flow to a high-flow priapism. This conversion has rarely been reported. It ...
Alam Iftikhar - - 2012
Multicenter immune monitoring programs commonly rely on storing and shipping cryopreserved peripheral blood mononuclear cells (PBMC), isolated from whole blood before freezing. However, under many conditions in the field, facilities to separate PBMC are absent. Here, we investigate the feasibility of using whole blood (WB) frozen at -80°C as a ...
Tsui Po-Hsiang - - 2012
Detection of blood clotting by ultrasound has been widely explored. Many ultrasonic quantitative parameters have been demonstrated to have the ability to characterize clot. This study proposes the ultrasound Nakagami image as a tool to visually characterize the properties of blood clot. Whole blood samples with a hematocrit of 40% ...
Rios Danyelle R A - - 2012
Several studies have demonstrated that non-O blood groups subjects present an increased VTE risk as compared to those carrying O blood group. The aim of this study was to investigate the ABO blood groups influence on factor VIII (FVIII) activity, von Willebrand factor (VWF), and ADAMTS13 plasma levels in patients ...
Wright Cameron - - 2012
To characterize the ability of high-intensity focused ultrasound to achieve thrombolysis in vitro and investigate the feasibility of this approach as a means of restoring blood flow in thrombus-occluded arteries in vivo. All experiments were approved by the Institutional Animal Care Committee. Thrombolysis was performed with a 1.51-MHz focused ultrasound ...
Joy P J - - 2012
A significant proportion of all red cell transfusions are given to patients undergoing elective orthopaedic surgery. Concern over transfusion safety and cost, coupled with evidence showing that restrictive transfusion policies benefit patients, prompted us to audit our blood prescribing practice at Gloucestershire Hospitals NHS Foundation Trust in order to assess ...
Long Tobias C - - 2012
A challenge to the development of pediatric ventricular assist devices (PVADs) is the use of the aortic cannulae attached to the devices. Cannulae used for pediatric application have small diameters and large pressure drops. Furthermore, during the development of the 12cc Penn State pediatric PVAD, particle image velocimetry (PIV) illustrated ...
Pieracci Fredric M - - 2012
BACKGROUND: In vitro data suggest that erythrocytes undergo storage time-dependent degradation, eventuating in hemolysis. We hypothesize that transfusion of old blood, as compared with newer blood, results in a smaller increment in hematocrit. METHODS: We performed an analysis of packed red blood cell transfusions administered in the surgical intensive care ...
Neurath D - - 2012
BACKGROUND: Although the National blood system in Canada reduces the risk of inventory shortages the possibility of a blood supply shortage still exists. The Ontario Ministry of Health and Long-Term Care developed a provincial plan to manage blood transfusion needs and inventory in the event of a National blood shortage. ...
Li Xiang-Yang - - 2012
The aim of this study was to investigate the pharmacokinetics of sulfamethoxazole in native Han and Tibetan healthy Chinese subjects living chronically at high altitude. An open-labeled, controlled, prospective study was conducted in healthy Chinese male volunteers. Sulfamethoxazole 1,200 mg was administered orally to two groups: native Han and Tibetan volunteers ...
Harris M - - 2012
BACKGROUND: Blood samples banked for up to 1 month are typically used to perform pretransfusion testing in humans and small animals, but this has not been validated using blood from horses. HYPOTHESIS: Compatibility of equine blood samples is repeatable using fresh samples, and reproducible using donor blood samples stored for up ...
Değirmenci Aysu - - 2012
Malaria was expected to be a major problem during blood donation in Turkey due to existence of malaria cases in southeastern region of Turkey. The present study aimed for the first time, to investigate malaria in "donors deferred for malaria risk" and to determine the regional rates of malaria deferral ...
Mordini Federico E - - 2012
A time-resolved spin-labeled cineangiographic MRI technique for visualizing blood flow in the heart and defects of the atrial septum is described. The method utilizes a spin labeling preparation and a time-resolved balanced steady-state free precession imaging readout that enhances blood in the left atrium or right atrium and suppresses background ...
Tao S - - 2012
Faecal occult blood tests (FOBTs) are widely used for colorectal cancer (CRC) screening. Blood-based inflammatory markers have been suggested as alternative or supplementary non-invasive CRC screening tests. Among 179 CRC patients, 193 people with advanced adenoma and 225 people free of neoplasm, C-reactive protein (CRP), serum CD26 (sCD26), complement C3a ...
Roberson Russell S - - 2012
Stored red blood cells (RBCs) accumulate biochemical and biophysical changes. Maximum storage duration is based on acceptable in vitro characteristics and 24-hour survival, but not RBC function. Relatively little is known about the impact of RBC storage duration on oxygenation and the microcirculation. Eight healthy subjects donated a double RBC ...
Lee Daeho D Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA. - - 2012
When evaluating the severity of valvular stenosis, the peak velocity of the blood flow is routinely used to estimate the transvalvular pressure gradient. One-dimensional Fourier velocity encoding effectively detects the peak velocity with an ungated time series of spatially resolved velocity spectra in real time. However, measurement accuracy can be ...
Niu Lili - - 2012
Many cardiovascular diseases are closely associated with the mechanical properties of arterial wall and hemodynamic parameters. Simultaneous measurements of the arterial strain and flow pattern may aid diagnosis of cardiovascular diseases and may be useful to study fluid-structure interaction between blood and vessel. This paper proposes a 2D non-invasive ultrasonic ...
Liu Gangjun - - 2012
In this paper, the features of the intensity-based Doppler variance (IBDV) method were analyzed systemically with a flow phantom. The effects of beam scanning density, flow rate and the time interval between neighboring A-lines on the performance of this method were investigated. The IBDV method can be used to quantify ...
Uribe Sergio - - 2012
We report hemodynamic findings in two patients with pulmonary atresia and intact ventricular septum (PAIVS) after "one-and-a-half ventricle repair" and placement of a bidirectional Glenn shunt using four-dimensional (4D) flow magnetic resonance imaging. Quantification of flow and analysis of flow patterns revealed the hemodynamic "battle" between the right ventricle (RV) ...
Lownik E - - 2012
Background and Objectives  Knowledge, attitude and practice (KAP) surveys have been used in many countries to understand factors that influence blood donation and as the basis for communication and donor mobilization strategies. Materials and Methods  A search was conducted of publically available databases, and studies with the following characteristics were ...
Yiallourou Theresia I - - 2012
PURPOSE: Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no widespread accepted protocol. We studied the physiologic influence of ...
Scrascia G - - 2012
Cell saving systems are commonly used during cardiac operations to improve hemoglobin levels and to reduce blood product requirements. We analyzed the effects of residual pump blood salvage through a cell saver on coagulation and fibrinolysis activation and on postoperative hemoglobin levels. Thirty-four elective coronary artery bypass graft (CABG) patients ...
Martin D S - - 2012
The impact of hypoxaemia on blood coagulation remains unclear despite use of a variety of measures to address the issue. We report the first use of thromboelastography (TEG) at high altitude to describe the dynamics of clot formation in whole blood samples. Seventeen healthy volunteers ascended to 5,300 m following ...
Lee Ching-Chang - - 2012
Methylmercury (MeHg), a well-known neuro-toxicant, is usually emitted by industrial and other man-made activities; it is ingested with seafood and shellfish, and accumulates in the human body. The aim of this study was to compare the differences in blood levels of total mercury (T-Hg) and MeHg in residents of 4 ...
Sanghera Bal - - 2012
Purpose:To characterize the two-dimensional (2D) and three-dimensional (3D) fractal properties of rectal cancer regional blood flow assessed by using volumetric helical perfusion computed tomography (CT) and to determine its reproducibility.Materials and Methods:Institutional review board approval and informed consent were obtained. Ten prospective patients (eight men, two women; mean age, 72.3 ...
Grabowski Eric F - - 2012
Hemostasis and thrombosis are now increasingly recognized as integrally related to blood rheology and blood flow. Platelets, for example, are known to access the vessel wall in ways which depend upon the small-scale motions of neighboring erythrocytes, and access one another via collisions driven by gradients in blood flow velocity. ...
Mitrophanov Alexander Y - - 2012
BACKGROUND: Blood dilution is a frequent complication of massive transfusion during trauma and surgery. This article investigates the quantitative effects of blood plasma dilution on thrombin generation in the context of intersubject variability. STUDY DESIGN AND METHODS: A thoroughly validated computational model was used to simulate thrombin generation curves for ...
Kalkman J - - 2012
We investigate the effect of multiple scattering on the optical coherence tomography (OCT) signal and the Doppler OCT signal of flowing blood. Doppler OCT measurements at 1300 nm are performed on flowing diluted porcine blood with hematocrit ranging between 0% and 15%. Measured blood hematocrit and mean red blood cell ...
Yao J - - 2012
Blood flow is a key parameter in studying cancer angiogenesis and hypermetabolism. Current photoacoustic blood flow estimation methods focus on either the axial or transverse component of the flow vector. However, the Doppler angle (beam-to-flow angle) is needed to calculate the total flow speed, and it cannot always be estimated ...
Seruya Mitchel - - 2012
BACKGROUND: Blood loss during fronto-orbital advancement (FOA) remains a significant potential source of morbidity. This study explored variables that might correlate with calculated blood loss (CBL) during this procedure. METHODS: The authors reviewed infants with craniosynostosis who underwent primary FOA (1997-2009). Patient demographics, operative time, and mean arterial pressure (MAP) ...
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