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Smalinskienė, Alina
The aims of this study were to detect the distribution of Cd and Zn in mouse internal organs and blood over six weeks of intoxication with Cd and exposure to Zn, and to estimate the effect of Zn2+ and Cd2+ on the mitotic activity of liver cells. Administration of Zn ...
Gittens Beatrice R BR William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, - - 2015
Numerous protocols exist for investigating leukocyte recruitment both in vitro and in vivo. Here we describe three of these methods; an in vitro flow chamber assay, intravital microscopy, and zymosan-induced peritonitis, and give details as to how they can be used to study the actions of galectins on this crucial ...
Dhar Rajat R Department of Neurology (Neurocritical Care Section), Washington University in St. Louis School of Medicine, 8111, 660S Euclid Avenue, St. Louis, MO, 63110, USA, - - 2015
Delayed cerebral ischemia (DCI) and cerebral infarction are major contributors to poor functional recovery after subarachnoid hemorrhage (SAH). Cerebral vasospasm, the narrowing of proximal intracranial arteries after SAH, has long been assumed to be the primary cause of DCI, and has therefore been the primary therapeutic target in attempts to ...
Elmoazzen Heidi H Canadian Blood Services National Public Cord Blood Bank, Ottawa, ON, - - 2015
Allogeneic umbilical cord blood (UCB) hematopoietic stem cell transplantation has become a crucial advancement in the treatment for a variety of diseases including hematopoietic and non-hematopoietic malignancies, BM failure syndromes, hemoglobinopathies, and metabolic and immunodeficiency disorders. It has been well documented that the success of UCB engraftment is tied to ...
Green L L NHS Blood and Transplant, Barts Health NHS Trust and Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, - - 2015
The clinical practice of blood transfusion has changed considerably over the last few decades. The potential risk of transfusion transmissible diseases has directed efforts towards the production of safe and high quality blood. All transfusion services now operate in an environment of ever-increasing regulatory controls encompassing all aspects of blood ...
Ribatti Domenico D Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico - Piazza G. Cesare, 11, 70124, Bari, Italy, - - 2015
Development of the vascular system involves a complex sequence of inductive and differentiating signals leading to vasculogenesis and/or angiogenesis. Dissecting and exploring this process in its multifaceted morphological and molecular aspects has represented a basic contribution and a fascinating adventure in the history of biology. Vasculogenesis, that is de novo ...
Thiagarajah Kalaivani K Cryocord, Cyberjaya, Selangor, - - 2014
Processed umbilical cord blood (UCB) must be stored at cryogenic temperature at all times to maintain the quality and viability of the cells. However, a challenge is presented in the form of moving a large number of cryopreserved UCB samples to a new location. In this report, we share our ...
Zegarra-Parodi Rafael R From the A.T. Still Research Institute at A.T. Still University in Kirksville, Missouri (Mr Zegarra-Parodi and Drs Snider and Degenhardt), and the Department of Neurobehavorial Sciences (Dr Snider) at the A.T. Still University-Kirksville College of Osteopathic Medicine in Missouri (ATSU-KCOM). Student Doctor Park is a third-year osteopathic medical student at ATSU-KCOM - - 2014
Laser Doppler flowmetry (LDF) is commonly used in combination with reactivity tests to noninvasively evaluate skin sympathetic nerve activity and skin microvascular function. In manual medicine research, LDF has been used as a marker for global peripheral sympathetic nervous system function, but these results should be considered with caution because ...
Deadman Benjamin J BJ Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork - - 2014
The synthetic utilities of the diazo and diazonium groups are matched only by their reputation for explosive decomposition. Continuous processing technology offers new opportunities to make and use these versatile intermediates at a range of scales with improved safety over traditional batch processes. In this minireview, the state of the ...
Kumar Rahul Prasanna RP The Intervention Centre, Oslo University Hospital, Sognsvannsveien 20, 0372, Oslo, Norway, - - 2014
The segmentation of tubular tree structures like vessel systems in volumetric datasets is of vital interest for many medical applications. In this paper we present a novel, semi-automatic method for blood vessel segmentation and centerline extraction, by tracking the blood vessel tree from a user-initiated seed point to the ends ...
Chen Mao M Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 - - 2014
A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide ...
Naing May Win MW Centre for Biological Engineering, Healthcare Engineering Research Group, Loughborough University, Loughborough, United - - 2014
With the rising use of umbilical cord blood (UCB) as an alternative source of hematopoietic stem cells, storage inventories of UCB have grown, giving rise to genetically diverse inventories globally. In the absence of reliable markers such as CD34 or counts of colony-forming units, total nucleated cell (TNC) counts are ...
van der Meer Pieter F PF Sanquin Blood Bank, Amsterdam, the Netherlands. Electronic address: - - 2014
Whole blood is not usually collected close to the processing site, which results in a holding time between collection and processing. In some countries, the holding time is limited to 8 hours, after which the units are cooled, rendering them useless for platelet preparation. Other countries allow a 24-hour ("overnight") ...
Gemoets Hannes P L HP Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology , Den Dolech 2, 5612 AZ Eindhoven, The - - 2014
Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and ...
Lee Ada - - 2014
Circulating tumor cells (CTCs) have gained increasing attention owing to their roles in cancer recurrence and progression. Due to the rarity of CTCs in the bloodstream, an enrichment process is essential for effective target cell characterization. However, in a typical pressure-driven microfluidic system, the enrichment process generally requires complicated equipment ...
Baumann Cyrille C Department of Anaesthesia, University Children's Hospital Zurich, Zurich, - - 2014
Autotransfusion in pediatric anesthesia is beneficial in several clinical settings; however, more frequent usage is deterred by process-related costs and the fact that the absolute volume of blood returned may be minimal. Two autotransfusion devices (CATS, Fresenius Kabi AG, and Sorin Xtra, Sorin GmbH) with different technologies were evaluated to ...
Dumont Larry J LJ Geisel School of Medicine at Dartmouth, Lebanon, New - - 2014
Overnight, room temperature hold (ONH) of whole blood before component processing offers several benefits. This study evaluated the storage and in vivo recovery characteristics of ONH red blood cells (RBCs) stored in additive solution-7 (AS-7). We conducted a three-center, three-arm evaluation of a new blood collection system with AS-7 compared ...
May J M JM Biomedical Engineering Research Group, School of Engineering and Mathematical Sciences, City University London, London, EC1V 0HB, - - 2014
Photoplethysmography (PPG) signals have been investigated at a new anatomical site, the anterior fontanelle (ANTF), on the hypothesis that blood supply at this location is preferentially preserved during cases of poor peripheral circulation which might cause the commercial pulse oximeters to fail to estimate accurately arterial blood oxygen saturation (SpO2). Two custom ...
Poh Jun-Jie - - 2014
Genomic DNA (gDNA) extraction from blood is a fundamental process in many diagnostic, identification, and research applications. Numerous extraction methods have been reported and are available commercially. However there is insufficient understanding of the impact of chemical buffers on DNA yield from either whole or nucleated blood. Moreover, these commercial ...
Moghaddam Mojtaba Mirhosseini MM Christian Doppler Laboratory for Flow Chemistry (CDLFC) and Institute of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz - - 2014
An experimentally easy to perform method for the generation of alumina-supported Fe3 O4 nanoparticles [(6±1) nm size, 0.67 wt %]and the use of this material in hydrazine-mediated heterogeneously catalyzed reductions of nitroarenes to anilines under batch and continuous-flow conditions is presented. The bench-stable, reusable nano-Fe3 O4 @Al2 O3 catalyst can selectively reduce functionalized ...
Kabeshov Mikhail A MA Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, - - 2014
An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading ...
Liu Jialin - - 2014
The slope of the inverse square of the contrast values versus camera exposure time at multi-exposure speckle imaging (MESI) can be a new indicator of flow velocity. The slope is linear as the diffuse coefficient in Brownian motion diffusion model and the mean velocity in ballistic motion model. Combining diffuse ...
Maeda Hisashi H Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, - - 2014
Local cooling and/or warming of the body are widely used for therapy. For safer and more effective therapy, microvascular hemodynamics needs to be clarified. To examine blood circulation in rat leg muscles at 20, 30, 37 and 40°C, fluorescein isothiocyanate (FITC)-labeled Lycopersicon esculentum lectin was injected into the cardiac ventricle. ...
Newman Bruce H BH American Red Cross Blood Services, Southeastern Michigan Region, Detroit, MI, - - 2014
The emphasis on high-school blood drives and acceptance of 16-year-old blood donors led to more research on physiologic and psychological ways to decrease vasovagal reaction rates in young blood donors and to increase donor retention. Research on how to accomplish this has been advantageous for the blood collection industry and ...
Wuethrich Alain A Australian Centre for Research on Separation Science (ACROSS), School of Physical Sciences-Chemistry, University of Tasmania, Private Bag 75, Hobart, TAS 7001, Australia. - - 2014
Zero net-flow was observed when acrylamide based hydrogel was used in a vial at one end of a fused-silica capillary during electrophoresis with electroosmotic flow. We demonstrate the detection of anionic compounds with the anode at the detector end and the field-enhanced sample injection of anionic small molecule drugs in ...
Esquivel Carlos J CJ Department of Entomology, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, United States of - - 2014
The consumption of a vertebrate blood meal by adult female mosquitoes is necessary for their reproduction, but it also presents significant physiological challenges to mosquito osmoregulation and metabolism. The renal (Malpighian) tubules of mosquitoes play critical roles in the initial processing of the blood meal by excreting excess water and ...
Smith Amy F AF Oxford Centre for Collaborative Applied Mathematics, Mathematical Institute, University of Oxford, Woodstock Road, Oxford, OX2 6GG, - - 2014
Transmural variations in the relationship between structural and fluid transport properties of myocardial capillary networks are determined via continuum modeling approaches using recent three-dimensional (3D) data on the microvascular structure. Specifically, the permeability tensor, which quantifies the inverse of the blood flow resistivity of the capillary network, is computed by ...
Chen Chia-Chern CC Department of Family Medicine, St Martin de Porres Hospital, Chiayi City, Taiwan, Republic of - - 2014
A plasma separating biochip is demonstrated using a capillary-driven contactless dielectrophoresis method with low voltage (~1 V) and high frequency induced electrostatics between red blood cells. The polarized red blood cells were aggregated and separated from plasma with a 69.8% volume separation and an 89.4% removal rate of red blood ...
Silva Jharon N JN Departments of Microbiology and Immunology, University of Rochester Medical - - 2014
HIV-1 infection of the central nervous system is associated with impairment of cerebral blood flow and neurocognitive function, and accelerated signs of aging. Since normal aging is associated with rarefaction of the cerebral vasculature, we set out to examine chronic viral effects on the cerebral vasculature. Doxycycline-inducible HIV-1 Tat transgenic ...
Ke Yifeng Y Tianjin Medical University Eye Hospital, Tianjin, China. Electronic address: - - 2014
To evaluate color Doppler imaging (CDI) as the primary imaging modality in the diagnosis of pediatric orbital capillary hemangioma. This is a retrospective study of 36 consecutive cases of orbital capillary hemangiomas between January 2006 and July 2011. Data on demographic details, clinical findings, gray-scale ultrasonography, CDI characteristics, treatment, and ...
Bresciani Francesca - - 2014
In human medicine the diagnosis of diabetic ketoacidosis (DKA) is usually based on the measurement of capillary 3-b-hydroxybutyrate (3-HB) with a hand held ketone sensor. The purpose of this study was to evaluate if the measurement of capillary 3-HB could be useful to diagnose and monitor the treatment of canine ...
Hata Shigefumi S Department of Physical Chemistry, Fritz Haber Institute of the Max Planck Society, Faradayweg 4-6, 14195 Berlin, - - 2014
The problem of stochastic advection of passive particles by circulating conserved flows on networks is formulated and investigated. The particles undergo transitions between the nodes, with the transition rates determined by the flows passing through the links. Such stochastic advection processes lead to mixing of particles in the network and, ...
Desjardins Michèle M Department de Génie Électrique, Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, Quebec, Canada; Montreal Heart Institute, Montréal, Quebec, Canada. Electronic address: - - 2014
Age-related decreases in baseline cerebral blood flow have been measured with various imaging modalities, however, the contribution of capillary flow to this phenomenon remain to elucidate. This study used 2-photon laser scanning fluorescence microscopy to measure capillary diameter, red blood cell speed, and flux in individual capillaries in the sensory-motor ...
Vaquer Sergi S Critical Care Center, Sabadell Hospital, CIBER Enfermedades Respiratorias, Parc Tauli University Institute, Parc Taulí 1, 08208 Sabadell, - - 2014
Earlobe arterialized capillary blood gas analysis can be used to estimate arterial gas content and may be suitable for diagnosis and management of critically ill patients. However, its utility and applicability in the ICU setting remains unexplored. A prospective observational validation study was designed to evaluate this technique in a ...
Chan Hy H Emergency Department, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, - - 2014
Emergency departments (EDs) face problems with overcrowding, access block, cost containment, and increasing demand from patients. In order to resolve these problems, there is rising interest to an approach called "lean" management. This study aims to (1) evaluate the current patient flow in ED, (2) to identify and eliminate the ...
Brazhe Alexey R AR Department of Biophysics, Biological Faculty, Moscow State University, Moscow, - - 2014
Full-field laser speckle microscopy provides real-time imaging of superficial blood flow rate. Here we apply continuous wavelet transform to time series of speckle-estimated blood flow from each pixel of the images to map synchronous patterns in instantaneous frequency and phase on the surface of rat kidneys. The regulatory mechanism in ...
Liu Yongsheng Y Department of Cardiology, the second Hospital of Jilin University, Changchun, 130041, - - 2014
Through research it is found that the barks, stems, fruits and flowers of Eucommia ulmoides contain various compositions, such as lignin, cycloalkane and phenylpropanoids. The modern pharmacological research shows that Eucommia ulmoides has many functions, such as anti-aging, antitumor and bone cell proliferation. This paper studied the resin purification process ...
Huang Tao - - 2013
To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into various Traditional Chinese Medicine (TCM) syndromes and treated for ...
Schneditz Daniel - - 2013
It was the aim to examine the fluid flow in blood and dialysate compartments of highly permeable hollow fiber dialyzers where internal filtration contributes to solute removal but where excessive filtration bears a risk of cell activation and damage. Flow characteristics of high- (HF) and low-flux (LF) dialyzers were studied ...
Sgouralis Ioannis - - 2013
We have developed a mathematical model of the rat's renal hemodynamics in the nephron level, and used that model to study flow control and signal transduction in the rat kidney. The model represents an afferent arteriole, glomerular filtration, and a segment of a short-loop nephron. The model afferent arteriole is ...
Lee Jonghwan J Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, - - 2013
As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, ...
Layton Anita T - - 2013
It has been observed experimentally that early distal tubular urea flow exceeds urea delivery by the proximal convoluted tubule to the pars recta and loop of Henle. Moreover, the fractional excretion of urea in the urine may exceed values compatible with the reabsorption known to occur in the proximal convoluted ...
Safavieh Roozbeh - - 2013
Microfluidic capillary systems employ surface tension effects to manipulate liquids, and are thus self-powered and self-regulated as liquid handling is structurally and chemically encoded in microscale conduits. However, capillary systems have been limited to perform simple fluidic operations. Here, we introduce complex capillary flow circuits that encode sequential flow of ...
Karam Zeina - - 2013
Aging is associated with structural and functional changes in the kidney. Structural changes include glomerulosclerosis, thickening of the basement membrane, increase in mesangial matrix, tubulointerstitial fibrosis and arteriosclerosis. Glomerular filtration rate is maintained until the fourth decade of life, after which it declines. Parallel reductions in renal blood flow occur ...
Spithoven E M - - 2013
As yet little is known about the effect of delayed separation of whole blood stored at room temperature on the stability of the kidney function markers creatinine and cystatin C. We used plasma samples of 45 patients with a wide range of creatinine and cystatin C concentration. Samples were sent ...
Restitutti Flavia - - 2013
To evaluate the dexmedetomidine-induced reduction in organ blood flow with quantitative contrast-enhanced ultrasound (CEUS) method and to observe the influence of MK-467 on such reduction. Randomized cross-over study. Six adult purpose-bred laboratory beagle dogs (mean body weight 15.3 ± 1.9 kg). Contrast-enhanced ultrasound was performed on six conscious healthy laboratory beagles. The animals ...
Lim Su Wei - - 2013
The aim of this study was to assess the potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict and evaluate functional outcome after renal artery revascularization for renal artery stenosis (RAS). Single-kidney glomerular filtration rate (SK-GFR) was measured in 15 patients with atherosclerotic RAS with DCE-MRI and radioisotopes at ...
Dyrna Felix - - 2013
The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs. An important prerequisite of this approach, however, would have been an equal ...
Lin Hsing-Hua - - 2013
OBJECTIVE: This study was undertaken to explore the association of estimated glomerular filtration rate (GFR) with exposure to aristolochic acids (ALAs) and nephrotoxic metals in herbalists after the ban of herbs containing ALAs in Taiwan. METHODS: This cross-sectional study recruited a total of 138 herbalists without end-stage renal disease or ...
Shi Liang L Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Göttingen, Germany and Institute of Geophysics, University of Göttingen, 37077 Göttingen, - - 2013
Laminar-turbulent intermittency is intrinsic to the transitional regime of a wide range of fluid flows including pipe, channel, boundary layer, and Couette flow. In the latter turbulent spots can grow and form continuous stripes, yet in the stripe-normal direction they remain interspersed by laminar fluid. We carry out direct numerical ...
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