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Results 401 - 450 of 633
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Jørgensen K A - - 1985
Five rabbit kidneys were perfused with human blood and another five with their own blood in a re-circulating oxygenated system at 37 degrees C. The flow decreased to 2 ml/min. within 30 min. in all xenoperfusions, while none of the autoperfused had decreased to this level by 60 min. Endothelial ...
Brown T P - - 1985
Three levels of hypovolemia were produced in awake and anesthetized domestic chickens by withdrawing 2.5, 5.0, or 10.0 ml blood per kg body weight. A commercial indirect blood-pressure monitor was unable to detect significant differences between hemorrhaged birds and age-matched controls. Perfusion-fixed kidney samples from unanesthetized birds had mitochondrial low-amplitude ...
Bálint P - - 1985
In the anesthetized dog renal blood flow (RBF) and its intrarenal distribution were investigated by the radioactive microsphere technique 24 hr after bilateral (BUL) and unilateral (UUL) ureteral ligation. In the control series indomethacin (IM) led to a decrease in RBF with outward shifting of zonal perfusions; imidazole (IA) did ...
Epstein M - - 1985
Beyond the age of 30, kidney size begins to decrease, and there are accompanying decreases in total renal blood flow, outer cortical flow, glomerular filtration rate and the ability both to conserve and to excrete sodium. There is also a decline in concentrating ability and possibly in diluting ability. These ...
Green M A - - 1985
The 68Ga and 111In complexes of PLED (N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid) were prepared and their biodistribution determined as a function of time following i.v. injection into rats. The 68Ga and 111In complexes behaved identically and were rapidly cleared from the blood via the kidneys into the urine. Similar rapid urinary excretion was ...
Iwasaki T - - 1985
The three-dimensional image data generated by the Dynamic Spatial Reconstructor (DSR) enables measurement of the three-dimensional distribution of blood supply in organs. We have applied this imaging technique to evaluate renal cortical blood flow distribution and compare it with distribution of radiolabeled microspheres. The DSR, a high temporal resolution volumetric ...
Rosenberg H - - 1985
In order to follow the catabolic fate of interferon in the body, [125I]-labeled human alpha interferon was infused into rats. Interferon activity and TCA-precipitable radioactivity in the blood reached a steady state after 60 min of infusion, while TCA-soluble radioactivity continued to increase during the entire infusion period. A massive ...
Erslev A J - - 1985
Severe erythrocytosis is associated with increased whole blood viscosity and impaired blood flow. Since a reduced blood flow will cause tissue hypoxia and since tissue hypoxia is associated with increased synthesis of erythropoietin, erythrocytosis per se should cause an increase in the rate of red cell production. This, however, does ...
Van de Vyver F L - - 1985
We report on a patient treated with hemoperfusion-hemodialysis (HP-HD) for severe paraquat poisoning. This procedure was adopted since the combination of adsorption and dialysis may improve overall drug removal. On admission blood paraquat was 15.8 micrograms/ml. He received conventional treatment and combined HP-HD which started within 3 hours after ingestion ...
Althoff M - - 1985
To determine the importance of chemoreflex control for microcirculation, we investigated tissue pO2 and local flow on the surface of muscle, kidney, liver, and heart under systemic hypoxia and under isolated hypoxic perfusion of the carotid body in anaesthetized (pentobarbital) and artificially ventilated cats. Under systemic hypoxia, local blood flow ...
Hörl W H - - 1985
The potential role of the kidney in renal serine synthesis was elucidated in rats following dietary serine as well as serine and glycine depletion for 6 weeks. Serine deficient diet caused a significant rise in blood serine and glycine values. In contrast, blood glycine concentration decreased significantly following serine and ...
Eldrup J - - 1985
The distribution of 133Xe from the bladder was investigated in sliced mice at autoradiography and quantitatively by counting tissue samples from the abdomen and thoracic cavity. Xenon is a highly diffusible inert gas that passes the bladder urothelium. In living mice activity could be seen in the intra-abdominal fat, liver ...
Munakata H - - 1985
Sialoglycopeptide fractions were prepared from the pronase digest of porcine kidneys by DEAE-Sephadex A-25 column chromatography and gel-filtration through Sephadex G-100. Their chemical compositions and large molecular size suggested that these glycopeptides were derived from mucin-type glycoprotein(s). The results of the beta-elimination reaction indicated that they have the O-glycosidic linkages ...
Nagy J - - 1985
Haematurias present serious problems in differential diagnostics. Although no clear-cut instructions exist, patients with haematuria are usually directed to urological surgeries or inpatient departments. Here they are routinely checked by a number of invasive techniques (cystoscopy, i. v. urography, aortography etc.) before the urological nature of haematuria can be ruled ...
Gelman S - - 1984
The effect of infrarenal cross-clamping of the aorta on regional splanchnic and renal circulations was studied in seven dogs. Regional blood flow was determined with differentially labeled microspheres (9 and 15 micron in diameter) that were injected simultaneously into the left atrium. Blood flow was measured 30 minutes after surgical ...
Corrigan D M - - 1984
The radiotracer 99Tcm DTPA is cleared from the blood by glomerular filtration. Measurement of the clearance rate of a radionuclide has previously required serial blood samples taken over a period of several hours. This report describes a technique where no blood samples are necessary and glomerular filtration rate (GFR) and ...
Briggs J P - - 1984
Studies were performed to characterize quantitatively the effect of changing loop of Henle flow rate on single nephron glomerular filtration rate (SNGFR) in male Sprague-Dawley rats of varying body weight. Rats weighing 100, 220, and 350 g were studied using standard renal micropuncture techniques. The relationship between loop of Henle ...
Wiegand H J - - 1984
Intratracheal instillation of 51CrCl3 in anaesthetized rabbits resulted in partial absorption. In blood, the absorbed material was entirely confined to the plasma compartment. Only trace amounts were deposited in liver and kidney. By contrast, after similar application of Na(2)51CrO4 the bulk of blood radioactivity was present in erythrocytes. Substantial deposition ...
Melgar M D - - 1984
The metabolism, disposition, and pharmacokinetics of tracazolate, (4-butylamino-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester), a novel anxiolytic agent, were studied in rat and dog following single oral and iv doses. Although tracazolate exhibits very good absorption (greater than 80%) in both species, it is extensively metabolized, accounting for low bioavailability. Excretion of 14C ...
Ventura H O - - 1984
The increased total peripheral resistance that characterizes essential hypertension is generally reversed by antihypertensive drugs, but the reduction may not be uniform in all regions of the body. In this study, regional blood flow was investigated immediately after the oral administration of 25 mg of captopril in 11 patients with ...
Angelborg C - - 1984
A new technique evaluates microcirculation in the different parts of the cochlea. It is a synthesis of two previously known methods--the microsphere method and the soft surface-specimen method. We studied the cochlear blood flow in ten albino rabbits using nonradioactive microspheres. The local distribution of microspheres in the cochlea was ...
Colley P S - - 1984
We used the radioactive microsphere method to measure and compare the effects of sodium nitroprusside (SNP) and nitroglycerin (NTG) on organ blood flow during hypotension induced by each drug. The study was done in 10 dogs anesthetized using 0.7% end-tidal halothane. Each animal received both SNP and NTG to decrease ...
Klintmalm G B - - 1984
The intraoperative blood flow, oxygen extraction, and prostaglandin production were studied in 26 transplanted kidneys. Eleven were from related donors and 15 from cadavers. Postoperative dialysis was required by four of the five recipients of a cadaveric kidney having an intraoperative blood flow of less than 200 ml/min/100 gm of ...
Mir S - - 1984
Six adult mongrel dogs received bilateral sequential renal arterial injections of degradable starch microspheres following preadministration arteriograms. Renal arterial flow was measured using electromagnetic flow probes, and microspheres were administered until flow was blocked completely. One kidney in each dog was subjected to immediate postembolization arteriography, while the contralateral kidney ...
Rijkmans B G - - 1984
Successful 6-day kidney preservation was obtained with a combination of perfusion techniques. Canine kidneys were preserved by hypothermic continuous perfusion in a Gambro machine with albumin perfusate. On day 3 the hypothermic preservation was interrupted by a normothermic perfusion for 3 hr. This intermediate perfusion was performed in a heart-lung ...
Hermansson K - - 1984
Stimulation of the intact renal nerve bundle at a frequency of 5 Hz was found to affect not only the blood flow of the ipsilateral kidney, but also the contralateral kidney responded with a 15% reduction in its total and regional renal blood flow. If the nerves were cut proximal ...
Luke R L - - 1984
The selective permeability of the glomerular basement membrane to macromolecules is a function of the size and charge of the macromolecule. Evidence suggests that shape may also be a factor. The orientation of macromolecules in solution is dependent on their size, shape, and frictional interactions with moving solvent molecules. The ...
Briggs J P - - 1984
Studies were performed in male Munich-Wistar rats weighing a mean of 100 g to evaluate further the hemodynamic effects of changing loop of Henle flow rate. When late proximal flow rate was varied by microperfusion from the late proximal tubule, single nephron glomerular filtration rate (SNGFR) measured in the early ...
Fleck C - - 1984
Immediately after unilateral nephrectomy ( uNX ) some different mechanisms of compensatory adaptation begin to act followed by a restoration of sufficient kidney function in a short time period. Beside biochemical changes early compensatory hypertrophy of the remaining kidney occurs. Simultaneously, functional adaptations of renal blood flow, glomerular filtration and ...
Prothero J - - 1984
Values of kidney weight in adult male and female mammals, both terrestrial and aquatic, as well as values for renal blood flow and glomerular number and diameter, were submitted to linear (log-log) regression analysis. The slope of the regression line for kidney weight in 63 species of adult terrestrial mammals ...
Smedsrud T - - 1984
The uptake and degradation of a mannose-terminated glycoprotein, yeast invertase, in char (Salmo alpinus L.) tissue was studied after intravenously injection of the 125I-labelled protein. 125I-labelled formaldehyde-treated human serum albumin (fHSA) and native HSA was also injected for comparison. Labelled invertase was rapidly cleared from blood and at about the ...
Collins G M - - 1984
Experiments were conducted using rabbit kidneys stored on ice for 48 hr to elucidate the mode of action of "intracellular" flush solutions. Measurements were made of renal function on a shunt and they were correlated with blood flow and the efficiency of the mechanical expulsion of red cells. By comparison ...
Ludwig B - - 1984
A 20-year-old man suffering from Crohn's disease developed coma and generalized seizures following ileocecal resection. During postoperative parenteral feeding he received xylitol in an unusually high concentration. CT examinations a few days before death showed intense hypodensity and swelling of brainstem and basal ganglia and increasing triventricular dilatation. Autopsy revealed, ...
Van Wart H E - - 1983
Stopped-flow cryoenzymology has been used to study the reaction of porcine kidney cytosol leucine aminopeptidase [alpha-aminoacyl-peptide hydrolase(cytosol), EC 3.4.11.1] with L-leucylglycyldansyl hydrazide in 50% (vol/vol) methanol buffer over the -40 to 23 degrees C temperature range. Resonance energy transfer between tryptophan residues of the enzyme E and the dansyl group ...
Osborn J L - - 1983
To investigate blood flow autoregulation in filtering and nonfiltering kidneys, renal blood flow was determined during graded reductions in renal perfusion pressure in seven anesthetized dogs containing both a filtering and nonfiltering kidney. In each dog, one kidney was made nonfiltering by the method of EH Blaine, JO Davis, and ...
Gotshall R W - - 1983
The effect of intrarenal arterial infusion of hyperoncotic dextran on renal hemodynamics and excretion was studied in anesthetized dogs. To examine the role of glomerular filtration and tubular flow in the hemodynamic response, several kidney models were employed. Nonfiltering kidneys (NFK) were produced by combined ischemia and ureteral obstruction (UO). ...
Hansson R - - 1983
The intrarenal erythrocyte distribution, total renal blood flow and renal vascular resistance were studied before and during recirculation after 60 min of warm ischaemia in three groups of rabbits. One group was pretreated with superoxide dismutase, another with catalase and the third group was not pretreated at all. In non-pretreated ...
Ofjord E S - - 1983
Microspheres (MS) provide somewhat erroneous estimates of intrarenal blood flow distribution due to a variable MS skimming. The errors were computed from two sets of model experiments. Skimming of 3.5-, 10-, and 15-micron MS and normal and hardened red blood cells (RBC and HRBC, respectively) were studied in a slit ...
Harris P - - 1983
These essays have traced the evolution of three great convective systems of the body: ventilation, circulation and excretion. We have seen how the ventilatory system evolved with an inherent susceptibility to flooding, how the kidney came to need an enormous blood flow and how a high blood pressure grew out ...
Mason J - - 1983
Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and reabsorption are more ...
Passmore J C - - 1983
To verify the freeze-dissection technique for measuring renal blood flow (RBF) distribution in anesthetized dogs we compared the sum of all compartment flow rates with total RBF, compared compartment flow distribution with intercepts, and determined recirculated 133Xe. By dissection, we found that the cortex, delineated by its granular brownish red ...
Brandani Pacini A - - 1983
Isolated rabbit kidneys were perfused in a closed-circuit system with a number of media such a Krebs-Henseleit bicarbonate buffer with albumin, homologous platelet-free plasma, serum and whole blood. All of these media were unsatisfactory. In contrast, fresh blood deprived of platelets, leukocytes, floating lipoproteins, microaggregates and microclots did not cause ...
Pflüger H - - 1983
In an effort to investigate the efficiency of various pharmacological agents in protecting the kidney against normothermic ischemia, an animal model was developed and the post-ischemic hemodynamics in the renal cortex of rabbit kidneys were studied. Renal cortical blood flow was evaluated 5-30 min after 60 min of normothermic ischemia ...
Wolgast M - - 1983
In the neonate kidney the glomerular filtration rate is generally depressed both in absolute terms and when calculated per gram kidney weight. Micropuncture studies have revealed that this phenomenon is due, not to changes in the driving pressures or the hydraulic conductivity of the glomerular capillary membrane, but to a ...
Allen W R - - 1983
Infusion of diazoxide, a potent benzothiazide antihypertensive, into the renal artery results in diuresis and natriuresis. The site within the nephron of decreased reabsorption has been controversial. Thus free flow recollection micropuncture studies of the superficial proximal tubule of the dog were undertaken to determine if diazoxide decreased sodium reabsorption ...
Szabó Z - - 1983
Various solutions of extra- and intracellular, or non-electrolyte type supplemented with papaverine or lidocaine were administered by gravity perfusion to 60 dog kidneys. Cooling in the kidneys perfused with the solutions containing papaverine lowered the temperature of kidneys in significantly shorter time than in those containing lidocaine. The histological examinations ...
Ståhl E - - 1983
The effect of unilateral ureteral occlusion on fibrin deposition in the kidney and the interrelation of the fibrin deposition and the renal blood flow was studied in rat. Intravascular coagulation in the kidney was induced by infusion of thrombin and inhibition of fibrinolysis with tranexamic acid. The effects unilateral occlusion ...
Castenholz A - - 1983
In Mercox-filled, non-corroded tissue the blood microvessels maintain the tubular shape they have in the intact circulation. Preparations treated in this manner are especially suited to reveal the fine structural features of the outer vascular wall and its relationship to the extravascular space in SEM. The outer wall morphology of ...
Schneider-Gilg A - - 1983
As indicated by changes in microsphere distribution in the rat, acute bilateral carotid artery occlusion (CAO) was found to cause a small but significant increase in outer cortical flow fraction. When renal perfusion pressure was kept constant, no redistribution occurred upon CAO. In denervated kidneys the redistribution induced by CAO ...
Ritschel W A - - 1983
The time related tissue distributions of coumarin (C), 7-hydroxycoumarin (7HC) and their metabolites were studied in DBA/lac mice following retro-orbital injection of 14C-labeled compound. The activity was determined as dpm/ml or g wet weight over a period of 120 min. C was found in blood, kidney, liver, muscle, brain, heart, ...
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