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Results 351 - 400 of 624
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Gatenbeck L - - 1987
Male genital blood flow and its regulation have not been fully clarified. In the present study we employed a radioactive microsphere technique to estimate the blood flow simultaneously in the major urogenital organs of male rats. The recorded genital flow rates varied among the rats. The relative blood perfusion rates ...
Frang D - - 1987
A modified surgical technique for calculous hydrocalyx, based on partial calyceal resection with simultaneous correction of the morphological abnormality responsible for stone formation is described. Access to the calyx is gained by a modified marginopolar resection. The modification developed by the authors consists in carrying the resection line laterally to ...
Häberle D A - - 1987
Ample evidence suggests that Ca2+ antagonists like nitrendipine are capable of inducing mild diuresis and natriuresis in states predisposing to natriuresis, although there is disagreement on common possible sites or mechanisms of action. To clarify this situation, clearance, micropuncture, and microperfusion studies were undertaken on rats to establish whether nitrendipine ...
Heller J - - 1987
The rabbit kidney, perfused under a constant pressure from the canine femoral artery is rejected (i.e. blood flow arrests) within several minutes. It cannot be prevented by intraarterial infusion of strong vasodilatators, such as verapamil and prostaglandin E2. Prostacyclin PGI2 infusion is capable of maintaining a sufficient blood flow and ...
Hynynen K - - 1987
A commercial diagnostic ultrasound scanner (Octoson) was modified for performing hyperthermia treatments. The temperature elevations were induced in tissues by four large, focused ultrasonic transducers whose common focal zone was scanned along a computer controlled path as determined from B-scan images. The system is described and the results of preliminary ...
Daemen M J - - 1986
To evaluate the merits of intrarenal drug delivery, the disposition of chromium-51 ethylenediaminetetraacetate (51Cr EDTA) and sodium o-[125I]iodohippurate (125I OIH) was studied following their constant-rate infusion into either the jugular vein or the left or right renal artery of Wistar Kyoto rats. The contralateral kidney was removed. Renal blood flow ...
Welbourne T C - - 1986
The regulation of interorgan glutamine flow was studied in control and chronically metabolically acidotic rats. Net glutamine extraction or production across the kidneys, gut, liver, and hindquarters was determined in fasted anesthetized animals from organ blood flows and the arteriovenous glutamine concentration difference. In control animals glutamine flows from the ...
Fuchs R - - 1986
The nephrotoxic mycotoxin ochratoxin A was studied in rainbow trout by whole-body autoradiography and scintillation counting using 14C-labelled toxin. After one single intravenous injection of 10 muCi/fish, corresponding to 160 ng toxin/g body weight, the tissue affinity was studied during an eight day period. As soon as 5 min. after ...
Peterson O W - - 1986
An analysis of glomerulo-tubular balance in the rat proximal tubule. Flow dependence of absolute proximal reabsorption (APR) or glomerulo-tubular balance (GTB) has been observed with spontaneous alterations in flow and attributed to both intraluminal and extraluminal factors. Flow dependent alterations in APR were demonstrated when 1. nephron filtration rate (SNGFR) ...
Arkin H - - 1986
Presented here is a theoretical analysis of the recently developed thermal pulse decay (TPD) method for a simultaneous measurement of local tissue conductivity and blood perfusion rate. The paper describes the theoretical model upon which the TPD method is based and details its capabilities and limitations. The theoretical aspects that ...
Yukimura T - - 1986
Intrarenal arterial infusion of a synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) in a dose of 5.0 micrograms/min to anesthetized dogs led to a significant increase in urine flow and urinary excretion of electrolytes. Tubular sites of action of alpha-hANP were determined by using free water clearance techniques and in stop-flow ...
Göransson A - - 1986
The influence of the renin-angiotensin system on whole-kidney and regional single-nephron function was studied in anesthetized Munich-Wistar rats by use of a converting enzyme inhibitor (CEI), captopril (3 mg . h-1 . kg-1 body wt-1). Single-nephron glomerular filtration rate (SNGFR) was measured in superficial (S) and juxtamedullary (JM) nephrons by ...
Steinhausen M - - 1986
The hydronephrotic rat kidney with intact circulation and innervation was split and spread out as a thin sheet in a tissue bath. The microvasculature was observed in vivo via television microscopy. We quantitated the effects of increasing concentrations (10(-9) to 10(-5) M) of saralasin (angiotensin II antagonist) applied locally in ...
Yoshida T - - 1986
Combinations of SF-2103A with cefotaxime, cefoperazone or cefazolin showed synergistic efficacy at a wide range of combination ratios against experimental infection in mice due to Proteus vulgaris GN76/C-1, producing type Ic cephalosporinase, Escherichia coli No. 29/36 RGN823, producing type IIIa (TEM-2) penicillinase and E. coli GN206, producing type Ib cephalosporinase. ...
Villarreal D - - 1986
The effects of synthetic atrial natriuretic factor on renin secretion were examined in anesthetized dogs with either a single filtering kidney or a single denervated nonfiltering kidney. In dogs with a single filtering kidney (Series 1, n = 6), a priming dose of atrial natriuretic factor (2 micrograms/kg, i.v.) followed ...
Milton A - - 1986
Renal handling and effects of tritium digoxin and interactions with quinidine in the avian kidney were studied using a modified Sperber technique. Results showed that tritium digoxin was extracted at the peritubular side of the nephron in a process competitively inhibited by increasing amounts of unlabelled digoxin. Light microscope autoradiography ...
McKercher H G - - 1986
An extraction procedure is described that allows the application of a commercially available enzyme-multiplied immunoassay technique to the measurement of digoxin in whole blood, liver, and kidney. The concentrations of digoxin were measured in tissues obtained at autopsy from five patients who had been taking therapeutic doses of digoxin prior ...
Yamaguchi Y - - 1986
In a study using a stop-flow technique in dog kidney, the existence of kallikrein and kinin was recognized in distal tubules. The presence of kininase I was seen in both distal and proximal tubules, and also partly in the distal tubules. The presence of kininase II in the distal tubules ...
Noddeland H - - 1986
Exposure to high gravitational forces acting along the body axis towards the feet (+Gz) causes considerable strain on several organ systems, including the kidneys. During +Gz tolerance studies without anti-G suits, significant amounts of protein and hyaline casts were found in 17 of 20 fighter pilots after centrifugation. The G ...
Belitsky P - - 1986
Four groups of three C57/BL6J mice were each given a single i.p. injection of Cyclosporine A (CYA) 3 mg/kg, containing 3H-CYA with 10 microCi activity. The groups were sacrificed after 5 minutes and at 6, 12 and 24 hours after dosing, respectively. They were immediately flushed with PBS to clear ...
Lach H - - 1986
The influence of a single dose of ACTH(100 I.U. /kg body weight) on the diurnal rhythm of reduced glutathione (GSH) was studied in the blood and brain, liver and kidney homogenates of male mice. Cosinor analysis revealed that ACTH induces changes in the mean diurnal amount of GSH in the ...
Sarper R M - - 1986
The accuracy of measuring anatomical blood flow using the rising slopes of first-pass time-activity curves were studied in six isolated dog kidneys. In each case, the canine kidney was placed on an open-circuit in vitro perfusion apparatus, which included an in-line flow meter and an in-line variable resistance for adjusting ...
Tamaki T - - 1986
Effects of ouabain on the autoregulation of renal blood flow (RBF) and renin release were examined in filtering and nonfiltering kidneys of anesthetized dogs. Autoregulation of RBF was observed in both kidneys; however, autoregulation in the nonfiltering kidney was comparatively less efficient. These findings indicate that both the myogenic mechanism ...
Dyckner T - - 1986
The majority of symptoms related to congestive heart failure (CHF) can be derived from the excessive accumulation of fluid in the body. The retention of fluid is the result of the activation of a complex system of compensatory mechanisms working on the kidneys and altering the hemodynamic situation in the ...
Langkopf B - - 1986
Kidneys of five pigs were preoperatively perfused with iloprost in situ (infusion of 0.5 microgram X kg-1 for 15 minutes) and exposed to a warm ischemic period of 45 minutes. The behaviour of these kidneys during initial perfusion by gravity and hypothermic mechanical perfusion for 24 hours was comparable to ...
Brown J A - - 1985
Scanning electron microscopy of corrosion casts of blood vessels permits detailed and accurate study of the microcirculation. The present study examined the renal microvasculature of the rainbow trout, Salmo gairdneri. The conventional picture of a glomerulus with one afferent arteriole was common, but glomeruli were often supplied by two afferent ...
Waldron C J - - 1985
The relative fractional distribution of 51Cr-labelled microspheres was evaluated in pithed rats during equieffective vascoconstrictor responses evoked by infusions of the alpha-adrenoreceptor agonists methoxamine (alpha 1-selective), UK-14,304 (alpha 2-selective) or vasopressin. The proportion of injected radioactive microspheres trapped in each tissue during a sustained pressor response relative to saline treated ...
Jørgensen K A - - 1985
Five rabbit kidneys were perfused with human blood and another five with their own blood in a re-circulating oxygenated system at 37 degrees C. The flow decreased to 2 ml/min. within 30 min. in all xenoperfusions, while none of the autoperfused had decreased to this level by 60 min. Endothelial ...
Brown T P - - 1985
Three levels of hypovolemia were produced in awake and anesthetized domestic chickens by withdrawing 2.5, 5.0, or 10.0 ml blood per kg body weight. A commercial indirect blood-pressure monitor was unable to detect significant differences between hemorrhaged birds and age-matched controls. Perfusion-fixed kidney samples from unanesthetized birds had mitochondrial low-amplitude ...
Bálint P - - 1985
In the anesthetized dog renal blood flow (RBF) and its intrarenal distribution were investigated by the radioactive microsphere technique 24 hr after bilateral (BUL) and unilateral (UUL) ureteral ligation. In the control series indomethacin (IM) led to a decrease in RBF with outward shifting of zonal perfusions; imidazole (IA) did ...
Epstein M - - 1985
Beyond the age of 30, kidney size begins to decrease, and there are accompanying decreases in total renal blood flow, outer cortical flow, glomerular filtration rate and the ability both to conserve and to excrete sodium. There is also a decline in concentrating ability and possibly in diluting ability. These ...
Erslev A J - - 1985
Severe erythrocytosis is associated with increased whole blood viscosity and impaired blood flow. Since a reduced blood flow will cause tissue hypoxia and since tissue hypoxia is associated with increased synthesis of erythropoietin, erythrocytosis per se should cause an increase in the rate of red cell production. This, however, does ...
Iwasaki T - - 1985
The three-dimensional image data generated by the Dynamic Spatial Reconstructor (DSR) enables measurement of the three-dimensional distribution of blood supply in organs. We have applied this imaging technique to evaluate renal cortical blood flow distribution and compare it with distribution of radiolabeled microspheres. The DSR, a high temporal resolution volumetric ...
Green M A - - 1985
The 68Ga and 111In complexes of PLED (N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid) were prepared and their biodistribution determined as a function of time following i.v. injection into rats. The 68Ga and 111In complexes behaved identically and were rapidly cleared from the blood via the kidneys into the urine. Similar rapid urinary excretion was ...
Rosenberg H - - 1985
In order to follow the catabolic fate of interferon in the body, [125I]-labeled human alpha interferon was infused into rats. Interferon activity and TCA-precipitable radioactivity in the blood reached a steady state after 60 min of infusion, while TCA-soluble radioactivity continued to increase during the entire infusion period. A massive ...
Althoff M - - 1985
To determine the importance of chemoreflex control for microcirculation, we investigated tissue pO2 and local flow on the surface of muscle, kidney, liver, and heart under systemic hypoxia and under isolated hypoxic perfusion of the carotid body in anaesthetized (pentobarbital) and artificially ventilated cats. Under systemic hypoxia, local blood flow ...
Nagy J - - 1985
Haematurias present serious problems in differential diagnostics. Although no clear-cut instructions exist, patients with haematuria are usually directed to urological surgeries or inpatient departments. Here they are routinely checked by a number of invasive techniques (cystoscopy, i. v. urography, aortography etc.) before the urological nature of haematuria can be ruled ...
Munakata H - - 1985
Sialoglycopeptide fractions were prepared from the pronase digest of porcine kidneys by DEAE-Sephadex A-25 column chromatography and gel-filtration through Sephadex G-100. Their chemical compositions and large molecular size suggested that these glycopeptides were derived from mucin-type glycoprotein(s). The results of the beta-elimination reaction indicated that they have the O-glycosidic linkages ...
Hörl W H - - 1985
The potential role of the kidney in renal serine synthesis was elucidated in rats following dietary serine as well as serine and glycine depletion for 6 weeks. Serine deficient diet caused a significant rise in blood serine and glycine values. In contrast, blood glycine concentration decreased significantly following serine and ...
Van de Vyver F L - - 1985
We report on a patient treated with hemoperfusion-hemodialysis (HP-HD) for severe paraquat poisoning. This procedure was adopted since the combination of adsorption and dialysis may improve overall drug removal. On admission blood paraquat was 15.8 micrograms/ml. He received conventional treatment and combined HP-HD which started within 3 hours after ingestion ...
Eldrup J - - 1985
The distribution of 133Xe from the bladder was investigated in sliced mice at autoradiography and quantitatively by counting tissue samples from the abdomen and thoracic cavity. Xenon is a highly diffusible inert gas that passes the bladder urothelium. In living mice activity could be seen in the intra-abdominal fat, liver ...
Gelman S - - 1984
The effect of infrarenal cross-clamping of the aorta on regional splanchnic and renal circulations was studied in seven dogs. Regional blood flow was determined with differentially labeled microspheres (9 and 15 micron in diameter) that were injected simultaneously into the left atrium. Blood flow was measured 30 minutes after surgical ...
Corrigan D M - - 1984
The radiotracer 99Tcm DTPA is cleared from the blood by glomerular filtration. Measurement of the clearance rate of a radionuclide has previously required serial blood samples taken over a period of several hours. This report describes a technique where no blood samples are necessary and glomerular filtration rate (GFR) and ...
Briggs J P - - 1984
Studies were performed to characterize quantitatively the effect of changing loop of Henle flow rate on single nephron glomerular filtration rate (SNGFR) in male Sprague-Dawley rats of varying body weight. Rats weighing 100, 220, and 350 g were studied using standard renal micropuncture techniques. The relationship between loop of Henle ...
Wiegand H J - - 1984
Intratracheal instillation of 51CrCl3 in anaesthetized rabbits resulted in partial absorption. In blood, the absorbed material was entirely confined to the plasma compartment. Only trace amounts were deposited in liver and kidney. By contrast, after similar application of Na(2)51CrO4 the bulk of blood radioactivity was present in erythrocytes. Substantial deposition ...
Melgar M D - - 1984
The metabolism, disposition, and pharmacokinetics of tracazolate, (4-butylamino-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester), a novel anxiolytic agent, were studied in rat and dog following single oral and iv doses. Although tracazolate exhibits very good absorption (greater than 80%) in both species, it is extensively metabolized, accounting for low bioavailability. Excretion of 14C ...
Ventura H O - - 1984
The increased total peripheral resistance that characterizes essential hypertension is generally reversed by antihypertensive drugs, but the reduction may not be uniform in all regions of the body. In this study, regional blood flow was investigated immediately after the oral administration of 25 mg of captopril in 11 patients with ...
Angelborg C - - 1984
A new technique evaluates microcirculation in the different parts of the cochlea. It is a synthesis of two previously known methods--the microsphere method and the soft surface-specimen method. We studied the cochlear blood flow in ten albino rabbits using nonradioactive microspheres. The local distribution of microspheres in the cochlea was ...
Colley P S - - 1984
We used the radioactive microsphere method to measure and compare the effects of sodium nitroprusside (SNP) and nitroglycerin (NTG) on organ blood flow during hypotension induced by each drug. The study was done in 10 dogs anesthetized using 0.7% end-tidal halothane. Each animal received both SNP and NTG to decrease ...
Klintmalm G B - - 1984
The intraoperative blood flow, oxygen extraction, and prostaglandin production were studied in 26 transplanted kidneys. Eleven were from related donors and 15 from cadavers. Postoperative dialysis was required by four of the five recipients of a cadaveric kidney having an intraoperative blood flow of less than 200 ml/min/100 gm of ...
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