Search Results
Results 201 - 250 of 621
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Jiang W - - 1997
OBJECTIVE: To verify from the aspects of immune senescence and free radical metabolism that "removing blood stasis as well as tonifying kidney is an ideal way to delay aging" and further investigate the anti-aging mechanism of this therapy. METHODS: In the first period, the old mice were separately fed with ...
Fahy G M - - 1997
The objective of the present study was to determine whether rabbit kidneys could be perfused with a 7.5 M vitrification solution (VS4, which vitrifies under applied pressure) without loss of function. To answer this question, kidneys were perfused with VS4 using a computer-based machine to gradually raise and lower concentration ...
Leyssac P P - - 1997
The effect of physiological concentrations of angiotensin II on proximal tubular fluid reabsorption remains controversial. To investigate the effect of blockade of intratubular AT1 receptors on tubular reabsorption, losartan (10(-5) M) was administered by microperfusion into an early proximal convolution of halothane-anesthetized Sprague-Dawley rats. Four parameters that depend on the ...
Sezai A - - 1997
We examined left ventricular assist during 6 h for an acute myocardial infarction model in pigs. The outflow cannula was placed in the ascending aorta and an inflow cannula in the left atrium. A pump (Pulsatile group: Zeon Medical and Nonpulsatile group: Nikkiso HPM-15) was connected to each cannula. Items ...
Cole T C TC - - 1997
RATIONALE AND OBJECTIVES: The authors investigate, in a controlled pig model, the usefulness of Doppler sonographic measurements of resistive index (RI), maximum velocity (Vmax), and mean velocity (Vmean) in diagnostic evaluation of the partially obstructed kidney. METHODS: Seven female pigs underwent surgical partial unilateral renal obstruction at the ureteropelvic junction. ...
Malinovsky L - - 1997
By means of immunohistochemical reactions, the authors proved the inhibitor II-related immunoreactivity in distal convoluted tubules of human kidney. A sharp inhibitor II-related immunoreactivity was also present in the blood vessels' wall. On the contrary, in the wall of proximal tubules and glomeruli only low reactivity was found. The demonstration ...
Davankov V A - - 1997
The replacement of conventional hemodialysis treatment for a patient with malfunctioning kidneys by providing him/her with a portable and disposable "artificial kidney" which is connected to implanted artery and veneous cannulas on a patient's wrist is discussed. During a continuous flow of blood, plasma diffuses through a plasmapheretic membrane, passes ...
Singal R K - - 1997
The development of a reliable, minimally invasive method of distinguishing physiologically significant renal obstruction from dilation without obstruction would have important clinical implications. As it is well known that renal blood flow decreases over time in the presence of obstruction, we investigated the ability of color flow Doppler ultrasonography and ...
Storck M - - 1997
Discordant xenotransplantation of pig kidneys into man may be possible in the future using transgenic organs which regulate complement activity. It was the aim of this experimental study to characterize morphologic alterations of organs transgenic for human decay accelerating factor (hDAF/CD55) perfused with human blood since no data on function ...
Rivers B J - - 1997
The resistive index (RI), an ultrasonographic method of evaluating intrarenal resistance to blood flow, may be used to aid in diagnosis of renal failure. Values for arcuate artery RI, expressed as mean +/- two standard deviations, were obtained in clinically normal female dogs sedated with atropine, acepromazine maleate, diazepam, and ...
Shafik A - - 1997
As an alternative to kidney transplantation in conditions of renal failure, an in situ kidney of a healthy individual may be used. The present study utilizes the kidney of a healthy rabbit as a hemoperfusion unit for another, uremic, animal. The study comprised 17 experimental models, each of which consisted ...
Taglialatela R - - 1997
Erythropoietin (EPO) stimulates differentiation of erythrocytes and biosynthesis of haemoglobin in mammals. It has not been confirmed that EPO is effective in other vertebrates, so we attempted to verify the effectiveness of human-urinary and recombinant EPO on erythropoiesis of the goldfish Carassius auratus. The results indicate that both types of ...
Larionova N I - - 1996
The modification of Bowman-Birk soybean protease inhibitor (BBI) with the monoaldehyde derivative of block copolymer of ethylene oxide and propylene oxide (PE), M(r) 2,000 is described. The conjugate contains five covalently bound polymer chains per protein molecule, and retains the ability to inhibit trypsin and chymotrypsin-like proteinases. The distribution of ...
Koch T - - 1996
The aim of this study was to investigate whether the oxygen radical scavenger N-acetylcysteine (N-AC) impairs bacterial clearance, thus predisposing the host to increased risk of disease. Blood clearance of Escherichia coli and organ colonization were investigated in anaesthetized rabbits after pretreatment with N-AC (250 mg kg-1 body weight, n ...
Willis L R - - 1996
PURPOSE: This study examined the acute time course of effects of extracorporeal shock wave lithotripsy (ESWL) on renal hemodynamics in anesthetized minipigs with and without pretreatment with verapamil. MATERIALS AND METHODS: We applied ESWL (2000 shocks, 24 kV, unmodified Dornier HM3), to the right kidneys of isoflurane-anesthetized female pigs. Urine ...
Breimer M E - - 1996
A pig kidney perfusion model aimed for use in immunological and physiological xenotransplantation research has been developed. Organ viability was characterised by clearance studies, functional response to hormones/diureticum and by light microscopical examination. The pig kidney was perfused in a specially designed plexiglass chamber, using a roller pump and a ...
Lindström K - - 1996
Total neutral glycolipid fractions were isolated from kidney and ureter tissue obtained at autopsy of an individual of the rare blood group A1 Le(a-b+) p. The amount of glycolipids isolated were 3.7 and 2.5 mg g-1 dry tissue weight for the kidney and ureter tissue, which is in the range ...
Thomson S C - - 1996
As single-nephron glomerular filtration rate (SNGFR) and late proximal flow (VLP) increase during growth or following volume expansion, the tubuloglomerular feedback (TGF) function (defined as the decrement in SNGFR due to the process of TGF) shifts rightward in the plane defined by VLP and SNGFR as required to maintain the ...
Yip K P - - 1996
Renal autoregulation of blood flow depends on the functions of the tubuloglomerular feedback (TGF) system and the myogenic response of the afferent arteriole. Studies of the dynamic aspects of these control mechanisms at the level of both the single nephron and the whole kidney have revealed a variety of non-linear ...
Ohno S - - 1996
Morphological studies using immersion or perfusion fixation methods do not reveal the ultrastructure of functioning kidneys with normal circulation. A simple apparatus was developed for freezing the kidneys in vivo without stopping the blood supply, and the ultrastructure of the glomerular capillary loops was examined under different haemodynamic conditions. Mouse ...
Field C M - - 1996
Visual assessment of renal blood flow from renography is usually achieved by comparing the count rate from the kidney with that of the spleen during the first pass of the radiopharmaceutical agent. This is not justifiable if splenic blood flow is abnormal. In nine subjects without evidence of renal or ...
Dejong C H - - 1996
BACKGROUND: During liver failure, urea synthesis capacity is impaired. In this situation the most important alternative pathway for ammonia detoxification is the formation of glutamine from ammonia and glutamate. Information is lacking about the quantitative and qualitative role of kidney and brain in ammonia detoxification during liver failure. METHODS: This ...
Romano G - - 1996
To differentiate intraluminal from peritubular factors in mediating the glomerulotubular balance, single nephron filtration rate (SNGFR) and reabsorption were measured by total collection from the last proximal segment before, and during, externally applied mechanical compression of an early proximal convolution of ninety-three rat nephrons. SNGFR fell from 55.6 +/- 2.3 ...
Kairemo K J - - 1996
Twelve nephrectomies (NEs) were performed in 12 pigs (11-17 kg). Total NE was performed on the left side and partial NE on the right side (lower third of the kidney), thus two-thirds of the total kidney volume was removed. Renal function was studied with 99mTc-diethylenetriaminepentaacetic acid (DTPA) renography and serum ...
Rivers B J - - 1996
Renal failure is an important cause of morbidity and mortality in feline patients. In human patients, intrarenal blood flow values obtained with duplex Doppler ultrasonography have been used to aid in the diagnosis and prognosis of renal failure. The purpose of this report is to present values for resistance to ...
Vallon V - - 1995
Nephron filtration rate (SNGFR) and proximal tubular reabsorption are coordinated by the processes of tubuloglomerular feedback (TGF) and glomerulotubular balance (GTB). We examined the role of nitric oxide (NO) in TGF and GTB, by delivering the NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) into late proximal nephrons by micropuncture in Inactin-anesthetized euvolemic ...
Rao P V - - 1995
BACKGROUND: It is proposed that retrograde abdominal perfusion be used in combination with retrograde cerebral perfusion to provide total body visceral protection during aortic reconstruction; however, its physiologic effects remain unknown. METHODS: We compared the effect of superior vena caval perfusion alone with that of combined superior and inferior vena ...
Baines A D - - 1995
We compared the ability of human red blood cells (RBC) and a cell-free oxygen carrier to maintain isolated perfused kidney function under moderately hypoxic conditions. Recirculating perfusate was gassed initially with 93% air-7% CO2, and, after 30 min, the gas was changed to 12 O2-7 CO2-81% N2. Oxygen content of ...
Willinger C C - - 1995
Since it became evident that organ dysfunctions after acute hemolysis are not induced by hemoglobin per se, but by stroma-contaminated hemoglobin, solutions of ultrapure stroma-free hemoglobins were regarded to be possible substitutes for blood in transfusion medicine. We tested one of the recently developed modified bovine hemoglobins (Ultrapure polymerized bovine ...
Manohar M - - 1995
Using radionuclide-labeled 15-microm-diameter microspheres injected into the left ventricle, we examined blood flow to the thyroid gland, adrenal glands, kidneys, and various gastrointestinal tract tissues in 9 healthy horses while they were standing quietly (rest) and during exercise at 2 work intensities (8 and 1 m/s). Hemodynamic measurements were made ...
Janssen W M - - 1995
A new technique for noninvasive measurement of intrarenal blood flow distribution over cortex and medulla is proposed. The technique involves analysis of 123I-labeled hippuran renography, according to a kinetic model that describes the flow of 123I-hippuran from the heart (input) through the renal cortex and medulla to the bladder (output). ...
Carroll J F - - 1995
There is little information on changes in overall and regional hemodynamics in obesity-associated hypertension. Therefore, the purpose of this study was to determine alterations in overall and regional blood flows and resistances in adipose and nonadipose tissues in a new model of obesity-associated hypertension in rabbits. Sixteen female New Zealand ...
Verkeste C M - - 1995
The objective of the present study was to evaluate whether placental blood flow (PBF) decreases or increases, in response to a fall or rise in mean arterial pressure (MAP), respectively, in an unanaesthetised animal model with a haemochorial placenta. Such a response would support the absence of autoregulation of placental ...
Greenfield S P - - 1995
95Niobium labeled radioactive microspheres were used to determine regional renal blood flows in a porcine model of chronic sterile vesicoureteral reflux. Unilateral vesicoureteral reflux was surgically created in 5 mini-pigs and regional renal blood flows were determined by microsphere injection 6 months later. The contralateral nonrefluxing kidney acted as a ...
Ihara H - - 1995
BACKGROUND: Tacrolimus (FK506) is currently used as the primary immunosuppressant in clinical kidney transplantation in some centers. The purpose of this study was to evaluate the pharmacokinetics of this drug and to see if trough level, which has been used widely in therapeutic drug monitoring, can be used as an ...
Julia P - - 1995
Reperfusion is a critical phase of organ preservation. The purpose of this study was to develop a solution specifically for postischemic kidney reperfusion. Unilateral left normothermic kidney ischemia was induced for 60 minutes in two groups of micropigs. In group 1 (control pigs, n = 6) the kidney was reperfused ...
Mezzogiorno V - - 1995
This work documents the fundamental contribution to the knowledge of lungs and kidneys made by Marcello Malpighi. For the first time, in "De Pulmonibus", he described the pulmonary alveoli and the network of capillary perialveolar blood vessels, establishing definitively the existence of a communication between arteries and veins. Furthermore, he ...
Zeiler M - - 1995
Urinary endothelin-1 excretion (uET-1/min) has been reported to be elevated under cyclosporin A (CsA) therapy in kidney transplant recipients (KR). The possible flow-dependence of uET-1/min was not considered. Therefore, we studied the effect of water diuresis on uET-1/min in KR 1 year after transplantation and used kidney donors (KD) as ...
Kairemo K J - - 1994
Iridium-191m (191mIr, t1/2 = 4.96 sec), an ultra-short lived tracer, has turned out to be suitable for gamma imaging. It can be obtained in high yields from an 191Os/191mIr-generator with a low 191Os breakthrough. In this study the blood flow in the carotid and kidney arteries was studied in rabbits ...
Yu G L - - 1994
The pressure wave of the abdominal aorta and the flow wave of the renal artery were recorded simultaneously from a rat. The impedance of a kidney system that is derived by dividing the pressure of the corresponding frequency by that of the flow was studied in six rats. The data ...
Drumond M C - - 1994
Previous studies have established that in a variety of human glomerulopathies the reduced glomerular filtration rate (GFR) is due to a marked lowering of the ultrafiltration coefficient (Kf). To identify the factors which lower Kf, we measured the filtering surface area per glomerulus, filtration slit frequency, basement membrane thickness, and ...
Ercan M T - - 1994
The purpose of this study was to demonstrate the accumulation of 99Tcm-glutathione (GSH) in experimental abscesses. The biodistribution of 99Tcm-GSH was determined in mice with turpentine-induced abscesses in comparison with 99Tcm-human immunoglobulin (HIG) at 1, 3, 6 and 24 h. Arthritis was induced by intra-articular injection of ovalbumin in the ...
Xu L X - - 1994
Corrosion casts of the plastic (Mercox Cl-2B) filled pig kidney cortex vasculature were sliced either parallel or perpendicular to the kidney surface. Scanning electron microscopy photographs were taken of the casts. Montages of the photographs were analyzed using a digitizing tablet and microcomputer-based software. For vessels having diameters larger than ...
Richet G C - - 1994
It was towards the end of the 18th century that a curiosity arose about what controlled the flow of urine. It was noted that though a patient's kidneys might be destroyed, the flow of urine continued until death. This puzzling phenomenon might have been understood had Ségalas's and Wöhler's observations ...
Dawson P - - 1994
One of the oldest questions in radiology, "what is the nephrogram?", has been approached in a novel manner using dynamic bolus contrast enhanced computed tomography to monitor the arrival and distribution of contrast agent in the normal kidney. A modification of a mathematical technique first developed for applications in positron ...
Abdelhamid A M - - 1994
Aflatoxin caused some reduction in moisture contents of chest and liver, lipids of thigh and blood, blood glucose, muscular protein and GOT in liver. It led also to increase of moisture contents of thigh and kidneys; chest lipids; blood cholesterol; protein of liver, kidneys and blood and blood creatinine. The ...
Gottschalk C W - - 1994
The overall structural organization of the kidney, its vasculature and its excretory units, the nephrons, was the subject of intense study and disagreement for hundreds of years. In 1783, Schumlansky received a doctoral degree with the dissertation De structura renum, in which he presented a detailed and comprehensive description of ...
Arany E - - 1993
Most insulin-like growth factor-I (IGF-I) in blood is found in complex with IGF binding protein-3 (IGFBP-3). An additional association of IGFBP-3 with an acid-labile subunit is thought to severely limit its ability to cross the vascular endothelium. However, it is not clear whether IGFBP-3 which is not complexed to acid-labile ...
Moon M H - - 1993
The applicability of field-low fractionation (FFF) to the characterization of liposomes is discussed and theoretically described. Because of fundamental differences in their driving forces, sedimentation FFF and flow FFF measure different vesicle properties. Sedimentation FFF, although used previously to measure vesicle sizes and size distributions, is fundamentally a technique that ...
Sigmon D H - - 1993
In two-kidney, one clip (2K1C) renovascular hypertension, blood flow is reduced to the clipped but not to the nonclipped kidney, despite elevated angiotensin II. To determine possible interactions between endothelium-derived nitric oxide and angiotensin, we studied bilateral renal blood flow using radioactive microspheres in anesthetized 2K1C hypertensive rats 4 weeks ...
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