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Results 601 - 633 of 633
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Nimmon C C - - 1975
Using a particular collimated NaI scintillation detector and a kidney phantom containing 131-I, the dependence of the resulting count rates on collimator-kidney geometry has been determined. These results have been used to calculate the geometrical contribution to the error in the measurement of relative effective renal plasma flow (REP) by ...
Lyrdal F - - 1975
After 1, 2, 4, 7, 14 and 21 days of ureteral occlusion, renal blood flow was measured on both sides by means of a dye-dilution method and the glomerular and tubular functions were evaluated by measuring the extraction of 51-Cr-EDTA and 125-I-Hippuran. The results showed an increase in the weight ...
Medakovic M - - 1975
The effects of urotensins I and II were studied on blood space and inulin space (with 51Cr-labelled erythrocytes and 14C inulin) in organs obtained from rats anaesthetized with pentobarbital. The findings were matched with the effects of urotensins on blood pressure and on perfusion pressure in the isolated perfused rat ...
Just M - - 1975
The bovine protease inhibitor aprotinin (Trasylol) has a high affinity to the kidney and is preferentially pinocytized in the proximal tubule. After i.v. injection of 1mug 124 I aprotinin the blood content decreases to 2.8% of the primary injected amount within 3 hrs, while simultaneously each kidney contains 29%. This ...
Maxie M G - - 1974
The clearance of (51)Cr-labelled Pseudomonas endotoxin from the blood was studied in calves in a nontolerant and in an endotoxin-tolerant state. Calves were rendered tolerant to the toxic effects of the endotoxin by four daily intravenous injections of endotoxin at the dose rate of 5 microg/kg body weight. Clearance of ...
Cox J W - - 1974
To further evaluate the mechanism of the oliguria of acute renal failure, a model was utilized in which intense and prolonged vasoconstriction produced the unilateral cessation of urine flow. The radioactive microsphere method was used to measure total and regional blood flow before and after the intrarenal infusion of norepinephrine, ...
Wright F S - - 1974
Microperfusion experiments have shown that increases in flow rate of tubule fluid through the loop of Henle are followed by reductions in single nephron glomerular filtration rate (SNGFR) and stop-flow pressure (SFP) measured in the proximal tubule of the same nephron. Because changes in luminal sodium concentration are not consistently ...
Kleinman L I - - 1974
1. The renal response to an intravenous saline load was studied in thirty new-born mongrel dogs aged 1-30 days and in seven adult dogs.2. After the infusion of isotonic saline at a rate of 2.0 ml. min(-1) kg(-1) for 15 min and then at a rate of 0.5 ml. min(-1) ...
Bruns F J - - 1974
A modification of the microdissection technique of Hanssen was utilized in dogs to measure superficial (SNGFR) and juxtamedullary nephron filtration rate (JMGFR) in control and saline-expanded dogs. During control studies SNGFR was 60+/-4 and JMGFR was 72+/-5 nl/min. During saline loading SNGFR was 74+/-8 and JMGFR was 65+/-6 nl/min. The ...
Mercer P F - - 1974
1. A method to measure total and cortical blood flow in the rat kidney has been described.2. Using this method it was found that total renal blood flow increased when rats were placed on both high and low sodium diets.3. Outer cortical blood flow in rats on a normal diet ...
Olbing H - - 1973
The intrarenal distribution of radionuclide microspheres injected into the thoracic aorta was used to examine glomerular blood flow distribution (GBFD) in 26 healthy, unanesthetized puppies, ranging in age from 5 h to 42 days, and in 5 adult dogs. For analysis, the cortex was divided into four equally thick zones ...
Kleinman L I - - 1973
1. Glomerular blood flow distribution was studied in seventy-eight new-born mongrel dogs aged 1-40 days by measuring the distribution of radioactive labelled microspheres within the kidney.2. The microsphere technique was found to be a valid indicator of glomerular blood flow distribution for the new-born dog since (a) the spheres were ...
Stein J H - - 1973
Studies were performed to define the mechanisms involved in the redistribution of renal cortical blood flow to inner cortical nephrons which occurs during hemorrhagic hypotension in the dog. The radioactive microsphere method was utilized to measure regional blood flow in the renal cortex. Renal nerve stimulation decreased renal blood flow ...
Kokko J P - - 1971
Transmembrane potential difference (pd) was studied in isolated perfused segments of rabbit proximal convoluted tubules. At perfusion flow rates above 10 nl/min the pd was -5.80 +/-0.3 mv (lumen negative) when perfusing with isosmolal ultrafiltrate of same rabbit serum as the bath. That this pd is generated by transport activity ...
Straus W - - 1971
The concentration of horseradish peroxidase in total particulate fractions from the kidney cortex did not change much during the first few hours after injection, as long as most of the injected protein was not yet cleared from the blood. It decreased at a rate of 6-8% per hr afterwards. The ...
Bencsãth P - - 1971
1. Intrarenal distribution of blood flow and cortico-medullary sodium gradients have been studied in anaesthetized dogs, previously subjected to unilateral splanchnicotomy. Experiments were carried out on hydropoenic, normal, isotonic and hypotonic volume expanded animals.2. Polyuria and natriuresis were present under all experimental conditions after denervation.3. Denervation resulted in an increase ...
Erikson U - - 1975
The total and regional blood flow conditions within the kidney were studied by videodensitometry. Animal and human investigations indicate on high accuracy of the method. No extra instillation is needed in the roentgen laboratory. The addition of physiolgical data is suppost to continue an additional diagnostic mean with presumably great ...
Nashat F S - - 1969
1. The effect of changes in the haematocrit of blood perfusing the kidney on its intrarenal distribution was studied in dogs.2. Two types of preparations were employed. (i) In the isolated perfused kidney evidence is presented that flow in the autoregulating preparation represents predominantly cortical flow while flow in the ...
Bentzel C J - - 1968
Volume changes due to osmotic flow in the distal portion of proximal tubules of Necturi were measured by the split oil drop technique. In agreement with previous findings no volume flow was induced by NaCl concentrations close to 60 mM. The tubule wall was found to be permeable to plasma ...
Lockett M F - - 1967
1. Cat kidneys have been perfused from pump-oxygenator and from heart-lung circuits.2. Kidneys perfused from the pump-oxygenator circuit excreted more water and sodium and showed higher values for sodium: potassium in urine than kidneys perfused from heart-lung circuits. Renal plasma flow and the clearances of creatinine and p-aminohippuric acid were ...
Lockett M F - - 1967
1. An hormonal influence of the heart on the isolated kidney has been demonstrated by insertion of hearts into pump-oxygenator circuits during renal perfusions.2. This hormone is a steroid which is secreted from the heart into the cardiac venous blood in response to reduction in venous input. The steroid is ...
Rosen S M - - 1967
Serial measurements of intrarenal distribution of blood flow have been recorded in anesthetized dogs with the (133)xenon "washout" technique. The results showed that normal kidneys redistributed their blood flow after laparotomy and mobilization of the kidney. This alteration consisted of a diminution in percentage of total renal blood flow supplied ...
Lockett M F - - 1966
1. Isolated cat kidneys perfused at constant pressure with blood from normal animals respond either to infusion or to injection of 0-9% NaCl (5-20 ml./150 ml. blood) by diuresis, natriuresis, a fall of the Na concentration in the urine, a fall followed by a rise in urinary Na/K and a ...
WEAVER A N - - 1956
An attempt to measure the distribution of blood in the functional kidney of dogs was made. The method involved the injection of liquid latex rubber into the vascular system at physiologic pressures, fixation of the rubber in situ, and then, after corroding away all tissue, measurement of the volume of ...
Drury D R - - 1938
A simple method is described for the production of renal insufficiency in rabbits by limiting the blood flow through one kidney and later removing the other. Renal insufficiency of any desired degree of severity can be obtained. The limitation of blood flow should be produced by allowing the artery to ...
Vonglahn W C - - 1935
1. The hemolytic Staphylococcus aureus elaborates a toxin in vitro that when injected intravenously produces lesions in the kidneys of rabbits and cats. 2. The toxin injures primarily the blood vessels of the kidney.
Moore R A - - 1929
1. Under the experimental conditions employed, from 44 to 78 per cent of the glomeruli of the normal rabbit kidney contain circulating blood at any one moment. 2. After unilateral nephrectomy the number of glomeruli in the remaining kidney, which contain circulating blood, is increased to 91 to 99 per ...
Hayman J M - - 1925
The results of thirteen control experiments, designed to show the number of glomeruli in the rabbit's kidney open to the circulation under the chosen experimental conditions without intentional interference, indicate the "normal" range to be from 42 to 100 per cent. Since ten of the thirteen results fall within the ...
Duval C W - - 1922
In general it may be said that three striking alterations occurred constantly in the animals reacting to intracardiac injections of blood from cases of measles; namely, pyrexia, leucopenia, and nephritis. The elevation in temperature usually began about the 9th day following inoculation, the rise being fairly abrupt from the normal ...
Watanabe C K - - 1918
1. Under the strain induced by the administration of urea, it is possible to demonstrate the relation between the degree of anatomical damage in the kidney and the degree of defect in the urea-excreting capacity induced by uranium. 2. The closest correlation between structure and function was obtained when the ...
Karsner H T - - 1914
These studies, like all studies of the kidney, are difficult of interpretation because of the impossibility of producing a pure glomerular or pure tubular nephritis. Arsenic nephritis in its early stage is physiologically a vascular nephritis, but anatomically tubular, and shows in this stage almost no retention of nitrogen, although ...
Winternitz M C - - 1910
Bicarbonate of soda fed in varying quantities over a period of months has no direct effect upon the catalytic activity of the blood. When fed to rabbits, it invariably causes a slight albuminuria and occasional casts. The kidneys of pregnant animals, especially in the later stages of pregnancy, seem to ...
Winternitz M C - - 1909
1. The inhibiting action of urine on catalase depends to a great extent on its reaction. The urine of a nephritic has no greater inhibiting power than normal urine provided the reaction of urines tested is neutral. 2. The catalytic activity of a single rabbit's blood is constant from day ...
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