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Kaloyanides G J - - 1977
1. Selected organ-ablation experiments were performed in dogs in an attempt to identify the source of the natriuretic hormone postulated to participate in the natriuresis of blood volume expansion. 2. An isolated dog kidney perfused with blood from the femoral artery of deoxycorticosterone-loaded dogs subjected to acute volume expansion with ...
Erikson U - - 1977
Videodensitometry has made it possible to determine not only total but also regional blood flow within the kidney. In animal experiments good agreement was found between the measurements by videodensitometry and isotope technique, taking vein samples, using 125I-labelled Angiografin. The blood flow in 21 human kidney has been determined by ...
Olsen U B - - 1977
Bumetanide (0.25 mg/kg intravenously) increases kidney volume by 20% at maximal diuresis in anaesthetized dogs. The kidney expansion is initially accompanied by a 2-4 fold increase in the subcapsular pressure, which is normalized at a time when kidney volume is still considerably increased. Renal blood flow and urinary kinin excretion ...
Johnson M D - - 1977
The radioactive microsphere method was used to study the distribution of cortical blood flow in anesthetized dogs during water diuresis and during antidiuresis. Infusion of antidiuretic hormone (ADH) at rates ranging from 0.33 to 0.5 mU/kg-min into dogs previously volume expanded with 3% dextrose resulted in an increase in urinary ...
Atkins H L - - 1977
Studies were undertaken to determine the biologic distribution of thallium-201 in man. The disappearance from the blood is extremely rapid and intracellular deposition is nearly immediate. The biologic half-time of thallium was measured by both the Brookhaven whole-body counter and the Donner whole-body scanner, with excellent agreement. The effective whole-body ...
Schuldt H H - - 1977
The value of intraoperative blood flow measurement during clinical kidney grafting to predict subsequent function was studied in the course of 19 consecutive transplantations. The results indicate that when blood pressure and heart rate of the recipients are within normal limits there exists a significant relationship between renal blood supply ...
Elling F - - 1977
In five female pigs, weighing approximately 100 kg, laparotomy was made under surgical anesthesia. One kidney was removed for immersion fixation and enzyme histochemistry, while the other kidney was fixed by vascular perfusion without prior interruption of the blood flow. A step-by-step description is given of the perfusion procedure, which ...
Fischer R - - 1977
This report describes the response of the renal circulation to prolonged hemorrhagic hypotension and reinfusion of blood, and to the effect of a variety of drugs (saralasin, indomethacin, and 6-hydroxydopamine, 6-OH-DA). Plastic microspheres were used to measure blood flow perfusing the entire kidney and also the outer cortex, inner cortex, ...
Warnock D G - - 1977
Proximal straight tubules from rabbit kidneys were perfused in vitro in order to study transport of bicarbonate. Total CO2 content was measured in perfused and collected tubule fluid, using microcalorimetry. When the initial perfusate and bath contained 25 mM bicarbonate, the concentration of total CO2 decreased in the collected tubule ...
Eisenberger F - - 1977
In 11 mongrel dogs both kidneys have been subjected to a 2 h ischaemic period. One kidney was cooled by perfusing the renal artery at 4 degrees C while the contralateral normothermic kidney was clamped for 2 h. Studying the renal blood flow using the Xenon wash out technique, sequential ...
Withey W R - - 1976
1. Renal function was measured in seven normo thermic (38 degrees C) and seven hypothermic (27 degrees C) dogs. 2. The glomerular filtration rate was 60 per cent lower in the hypothermic animals, and the renal blood flow as 51 per cent lower. The intrarenal distribution of blood flow was ...
Applegate C W - - 1976
In order to study the effect of anesthesia on the canine response to saline loading, experiments were performed on 10 dogs, first while awake and then during pentobarbital anesthesia. Individual kidney function and intrarenal blood flow response to saline loading (7.5% body weight) were measured in each condition and all ...
Coelho J B - - 1976
Conflicting data in studies of the effect of natriuresis on intrarenal single nephron glomerular filtration rate (SNGFR) redistribution may arise from the interplay of hitherto largely overlooked factors. In the present work, the effect of diuresis induced by saline, glucose or mannitol, as well as the effect of anatomical nephron ...
Morkrid L - - 1976
The effect on the intracortical distribution of microspheres and radioactivity caused by steric hindrance of the free movement of spheres into afferent arterioles are described by two mathematical models. The results are compared with corresponding experimental data obtained in six kidneys from normotensive dogs. The first model (A) assumes that ...
Braun E J - - 1976
The total-kidney glomerular filtration rate (GFR) falls when birds are salt loaded. This fall in GFR is caused by glomerular intermittency. The nephrons that stop filtering are small, surface nephrons without loops of Henle. Larger nephrons with loops of Henle in the deeper regions of the kidney continue to filter ...
Tark M - - 1976
The relationships between substrate utilization and renal work were investigated in an isolated, perfused dog kidney preparation: substrate utilization included free-fatty acid (FFA), glucose, and oxygen, whereas work was assessed by measuring TNa+. The magnitude of TNa+ was varied by altering glomerular filtration rate as a consequence of changing renal ...
Chenitz W R - - 1976
Glomerular blood flow in the rat, measured with radioactive microspheres, averaged 233 +/- 59 nl/min per glomerulus, significantly less than the glomerular flow rate in the dog (568 +/- 115; P less than 0.005). The difference in glomerular blood flow rate could not be attributed to differences in mean or ...
Hilson A J - - 1976
Comparison of the blood clearances of 51Cr-EDTA and 99Tcm-Sn-DTPA, in a series of 45 patients with a wide range of glomerular filtration rates, showed that there was a good correlation between the estimates of G.F.R. obtained using the two chelates simultaneously. The single-injection, single-exponential method of G.F.R. estimation was used, ...
Karow A M AM - - 1976
Rabbit kidney were perfused at 37degreesC with various concentrations of DMSO in a K+-Mg2+-rich perfusate. The effects of DMSO on various functional parameters of the rabbit kidney perfused for 60 min were compared with the functional effects of perfusion without DMSO under the same conditions. DMSO produced deviations in vascular ...
Shames D - - 1976
Totally isolated canine kidneys were perfused at 37 degrees C. for 240 minutes with whole blood from dogs that had undergone a sham operation or a unilateral nephrectomy 24 hours previously. Renal blood flow, glomerular filtration rate, serum sodium, and serum osmolality were not significantly different in the experimental and ...
Banks R O - - 1976
The distribution of labeled microspheres within the renal cortex was used to evaluate the influence of physiological amounts of antidiuretic hormone on intrarenal blood flow distribution in hypophysectomized dogs and in rats with hereditary diabetes insipidus. In both species, intravenous infusions of ADH caused a significant decrease in the ratio ...
Wen S F - - 1976
In order to study the tubular mechanism for salt retention in acute proliferative glomerulonephritis, clearance and micropuncture experiments were performed on nine volume-expanded dogs before and after injection of sheep anti-dog glomerular basement membrane (GBM) antibodies (nephrotoxic sera [NTS]). Histologic sections obtained two hours after NTS injection following completion of ...
Abitbol M M - - 1976
Experimental toxemia of pregnancy was induced in 51 of 122 rabbits by constriction of the aorta below the renal arteries. The approach was extraperitoneal and dependent on the accuracy in calibrating this stricture between 0.6 and 1.0 mm. Experimental toxemia in the rabbit was characterized by hypertension, proteinuria, weight gain, ...
Yarger W E - - 1976
In order to study renal salt-retaining mechanisms during the early stages of ascites formation, rats were subjected to bile duct ligation. After this procedure, plasma volumes were found to be reduced and hematocrits slightly increased. The whole-kidney glomberular filtration rate and plasma flows were reduced to 59 and 57% of ...
Dahlager J I - - 1976
The collateral blood flow to the rabbit kidney was determined by two methods: (1) measurement of the venous flow after clamping of the renal artery and (2) Hippuran clearance of the clamped kidney. The collateral blood flow was found to be 0.012 ml/min/g kidney equivalent to 0.2% of the entire ...
Schilling A - - 1976
Xenotransplantation in distantly related donor-recipient systems is rejected within minutes. According to present theories, hyperacute rejection is due to preformed antibodies. However, our results suggest that a nonimmunologic reaction plays a dominant role in the hyperacute rejection reaction. To analyze the hyperacute rejection reaction, a previously described model of isolated ...
Valentin N - - 1976
A new method for the determination of blood and tissue contents of silicone by atomic absorption spectrophotometry is described. Silicone was found in the blood, probably as droplets, in each of 14 patients undergoing open-heart surgery with the aid of a bubble oxygenator. In five fatal cases the brains and ...
Nomura G - - 1976
The effect of acute denervation of the kidney on renal sodium and water excretion, and hemodynamics including intrarenal blood flow, was studied in anesthetized dogs. The intrarenal blood flow was measured by the radioactive microsphere method. In all experiments denervation natriuresis and diuresis was observed without significant change in glomerular ...
Gomba S - - 1976
Dog kidneys were stored three hours at 4 degrees C in heparinized homologous blood. Their histological examination revealed the presence of a homogeneous precipitate in the glomerular capillaries and afferent and efferent arterioles, and histochemical analysis indicated that it consisted of glycoprotein. It is tentatively suggested that the substance is ...
Weeks J R - - 1976
The prostaglandins have diverse cardiovascular effects, differing not only among themselves but also according to the organ affected and the species. Some of the pharmacological actions of the prostaglandins may have practical application in hypertensive crises, shock, peripheral vascular disease, and to maintain the patency of the ductus arteriosus in ...
Tóth I - - 1976
Twenty-five swine kidney xenografts previously flushed with Collins-4 solution were perfused with canine blood and the functional and morphological changes resulting from xenoperfusion were studied. Blood flow of the kidneys practically ceased by the end of 8 minutes parallel with progressive swelling and cyanosis of the organ. Microscopic study of ...
Knox F G - - 1975
The sites of inhibited phosphate transport following administration of bovine parathyroid hormone (bPTH) to thyroparathyroidectomized (TPTX) dogs were investigated. Phosphate reabsorption by the proximal and distal nephron was studied using recollection micropuncture, stop-flow methodology, and electron-probe microanalysis. Following bPTH, delivery of phosphate from the proximal tubule increased from 26 to ...
Bálint P - - 1975
Viable kidney mass has been reduced in dogs by branch-artery ligation combined with uninephrectomy. 1. When viable kidney remnants amount to about 1/4 of the original kidney mass dogs survive in apparent good health with moderate azotaemia; with 1/8 to 1/10 kidney remnants azotaemia is progressive and uraemic death supervenes ...
Speroff L - - 1975
This review asserts that prostaglandins of the E family play a vital regulatory role in uteroplacental blood flow. This role appears to be similar to activity within other organs, especially the kidney, in a process referred to as autoregulation of blood flow. This mechanism may serve as a system for ...
Källskog O - - 1975
The quantitative relation between the driving forces over the glomerular membrane and the glomerular plasma flow, on the one hand, and the single glomerular filtration rate (SNGFR), on the other, is still uncertain. Micropuncture measurements on Sprague-Dawley rats made it possible to calculate the net driving force over the glomerular ...
Satoh S - - 1975
Partial occlusion of the renal artery (RAO) was induced in dogs anesthetized with pentobarbital or morphine chloralose-urethan. The effect of [Sar1, Ala8]angiotensin II (P-113) was compared before and during RAO on blood flow and vascular resistance of the contralateral kidney. An increase in renin secretion rate was obtained in the ...
Beeuwkes R R - - 1975
Tubular organization and vascular-tubular relations were studied by double injection in canine kidneys. Blood vessels were injected via the artery after perfusion fixation. Tubules were injected by micropipettes inserted into the urinary spaces of selected glomeruli in cleared slices. One hundred proximal convoluted tubules, 16 Henle loops, and 5 distal ...
Vanherweghem J L - - 1975
Blood-perfused isolated dog kidneys demonstrate steady increases in blood flow and in water and sodium excretion which could be attributed to the accumulation of renal prostaglandins in the perfusing blood. This hypothesis was tested by adding indomethacin, a potent inhibitor of prostaglandins synthesis, to the perfusing blood. Indomethacin completely prevented ...
Davies B N - - 1975
1 The responses of the smooth muscle of the capsule and blood vessels of the isolated, blood-perfused spleen of the dog to angiotensin, oxytocin and vasopressin have been investigated and compared to the actions of the catecholamines, adrenaline and noradrenaline.2 Increasing doses of each of the three polypeptides cause graded ...
Källskog O - - 1975
Regional renal and single glomerular blood flow was investigated in rats using 141-Ce and 85-Sr labelled microspheres. The kidneys were prepared for micropuncture and also the artery was catheterized with a steel cannula in order to make injections of 133-Xenon and vasoactive substances selectively into one kidney. The microspheres were ...
Velasquez M T - - 1975
Intrarenal blood flow and volume (indicator-dilution technique), kidney volume (mercury-in-rubber resistance gage), intr-renal venous pressure, filtration fraction, and sodium excretion were determined dequentially before and during a l-h infusion of isotonicsaline 80 ml/kg in anesthetized dogs. The cortical fraction of renal blood flow roseduring the first 20 min of infusion ...
Corica A P - - 1975
Intrarenal flow distribution in ischemic and nonischemic dog kidneys has been studied using the 133Xe washout technique and angiography. These preliminary studies showed two different hemodynamic alterations during perfusion, vasoconstriction, and diminution of cortical flow. Vasoconstriction of the renal artery and branches noted in both groups was observed to be ...
Ekberg M - - 1975
To elucidate the origin of the fibrin/fibrinogen degradation products (F.D.P.) occurring in the urine in glomerulonephritis 28 patients with glomerulonephritis were examined for renal fibrinolytic activity, F.D.P. in urine and serum, and blood fibrinolytic activators and blood fibrinolytic activators and inhibitors. Unlike the glomerful of healthy kidneys, which were fibrinolyticly ...
Kaloyanides G J - - 1975
Nonrecollection end-proximal tubule micropuncture technique and the microsphere method for estimating fractional distribution of renal cortical blood flow were applied to further define the mechanism of the natriuresis in the isolated dog kidney in response to volume expansion with equilibrated blood. Following volume expansion sodium excretion increased +79 plus or ...
Case D E - - 1975
1. 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine (I.C.I. 58,834) in three 14C-labelled forms, given orally to two male volunteers, was completely absorbed, extensively metabolized and rapidly eliminated via the kidney. 2. O-Dealkylation, the major metabolic pathway in the rat, was not significant in man. 3. The major component in blood at all times was I.C.I. ...
Helin I - - 1975
A unilateral, free, vesico-ureteric reflux was surgically created in six piglets. Three to four months later, glomerular and tubular function had decreased by about 50 per cent. The reflux also caused a reduction in the kidney's capacity to maintain a steady blood supply when the intravesical pressure was elevated.
de Jong J C - - 1975
In summary, in contrast to a blood-membrane interphase system (artificial kidney), the use of a blood-gas interphase system (bubble oxygenator), even at a low flow rate of 400 ml/min, leads to severe changes in platelet function and number, to a temporary delay in fibrin formation and to a prolonged bleeding ...
Almgård L E - - 1975
The effect of renal denervation on the reactivity of the renin release mechanism to circulating norepinephrine was studied in six dogs with renal autografts. The renin release was determined simultaneously in the transplanted and the untouched kidney. Both kidneys showed an increased release of renin when norepinephrine was given. A ...
Frödin L - - 1975
Rat kidneys were perfused in vitro with Perfadex (Gelin's solution) and a modified Collins' C3-solution with or without colloids. When the same flow rate was used the presence of 5% dextran 40, 5% albumin, or 10% albumin did not alter the clearing of 51Cr-tagged red blood cells. The main difference ...
Arendshorst W J - - 1975
We present evidence showing that renal blood flow (RBF) in the anesthetized nondiuretic rat can be measured reliably and accurately using a noncannulating flow transducer and an electromagnetic flowmeter. In vitro calibration yielded a linear relationship (r=0.998) between flowmeter output voltage and blood flow rates from 0.2 to 10.3 ml/min. ...
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