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Results 501 - 550 of 633
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Mareković Z - - 1980
The paper presents the possibilities of achieving regional renal hypothermia by rinsing the kidney venous system with a cooling solution. The cooling solution flows in and out of the kidney venous system through a specially constructed catheter with two lumens while the kidney is deprived of its blood flow. This ...
Gerber J G - - 1980
Furosemide administration results in an increase in blood flow through the prostaglandin system by causing the release of arachidonic acid from a small pool of lipid stores from the kidney without affecting the total arachidonic acid concentration in the blood. The stimulus for arachidonic acid release from the kidney depends ...
Göthlin J - - 1980
The renal blood flow and related variables were assessed with a dye dilution technique in conjunction with angiography of the enlarged kidney in 13 patients with unilateral disease, hypoplasia or aplasia of one kidney. The total renal blood flow, the width of the arteries, the kidney area, the vascular volume ...
Tanner G A - - 1979
The effects of chronic blockade of single kidney tubules on glomerular capillary pressure (GCP) and blood flow were examined in anesthetized rats. Tubule blockade with castor oil for 24 h decreased GCP from 48.0 +/- 3.8 to 39.5 +/- 4.7 mmHg (P less than 0.001). The full decrease in GCP ...
Mimran A - - 1979
The influence of microsphere size upon the estimation of cardiac output (CO), renal blood flow (RBF) and its cortical distribution (ICBFD) was evaluated by simultaneous injection of 8.5 +/- 0.8 micrometer (SD) and 12.7 +/- 1.7 micrometer (SD) spheres in control conditions and after hemorrhagic hypotension (HH rats). The values ...
Nizet A - - 1979
Tubular reabsorption was inhibited in isolated dog kidneys by the progressive substitution of plasma chloride by sulphate. In the absence of antidiuretic hormone activity, urine output remained unchanged owing to an equivalent decrease in glomerular filtration rate. This equilibrium was demonstrated under conditions of "saline natriuresis" and was not disturbed ...
Jones S M - - 1979
Differences in the rate of renin release by superficial and deep areas of the cat kidney cortex were studied in vitro and in vivo. Renin release in vitro by outer cortical slices was significantly higher than by their inner counterparts: 19.6 +/- 2.3 vs. 12.8 +/- 1.95 ng angiotensin I-h-1-mg ...
Butt T J - - 1979
A method is described for measuring distribution of intrarenal blood flow in anesthetized rats by a xenon-133 washout technique that avoids the trauma of opening the abdominal cavity and manipulating the kidney. Precise delivery of the tracer to the kidney and fine collimation of the radiation reduces the amount of ...
Clausen G - - 1979
Disparate reports on intrarenal blood flow distribution prompted a direct comparison between microspheres (Ms) and inert diffusible tracers (DT). The "tissue sampling technique" for estimating local flow with DT (Kety) was adapted for the dog kidney, using 125I-iodoantipyrine (1-Ap) and tritiated water (THO). Ms (15 micron) were injected 2-3 min ...
Powis D A - - 1979
In anesthetized vagotomized dogs with renal arterial pressure constant, carotid sinus hypotension (BCO) caused a reflex rise in systemic arterial pressure, a fall in renal blood flow, and a similar increase in renin release from both kidneys. Unilateral alpha-adrenoceptor blockade with phenoxybenzamine resulted in an increase in basal renal blood ...
Bastron R D - - 1979
Halothane-induced changes in renal function have generally been attributed to alterations in systemic hemodynamics, sympathetic tone, and various hormones. Studies were performed to determine whether halothane directly affects the kidney. Twenty-one canine kidneys were perfused in vitro utilizing hemodilution, pulsatile flow, and membrane oxygenation. Temperature and arterial blood-gas variables were ...
Schier J F - - 1979
In the presented series of experiments, stroma-free hemoglobin solution (SFHS) was used as a perfusate for extracorporeal perfusion of kidneys and for exchange transfusion. It was shown that SFHS was adequatly oxygenated both as perfusate during the extracorporal perfusion and in the lungs after the blood exchange. Furthermore, there was ...
László K - - 1979
Intrarenal haemodynamics were investigated in the dog prior to and after relief of 24 hr bilateral ureteral ligation (BUL), by the radioactive microsphere technique. Prior to release of 24 hr BUL there was an about 50% reduction in total blood flow (RBR), with a nearly proprotional decrease in the perfusion ...
Horpácsy G - - 1979
The effect of prednisone therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if the drug was directly injected into ...
Buhl M R - - 1979
Renal ischaemia produced by clamping of the blood vessels in situ for periods of 10 to 150 minutes resulted in a progressive depletion of the total content of adenylates in the kidney tissue (sigma ATP, ADP, AMP). Initial dephosphorylation of ATP and ADP, resulting in further catabolism of AMP to ...
Thomas S R - - 1978
This network thermodynamic model of kidney proximal tubule epithelium treats coupled salt and water flow across each component membrane of the epithelium. We investigate the effects of various relative internal parameter values on the concentration of transepithelial flow, the concentrations in the cell and interspace, and the distribution of flows ...
Kaloyanides G J - - 1978
We examined the role of the central nervous system in the activation of the humoral natriuretic mechanism elicited by blood volume expansion. Studies were performed in anesthetized dogs pretreated with deoxycorticosterone acetate (15 mg/day) and sodium chloride for 12 days. An isolated dog kidney perfused with blood from the femoral ...
Yarger W E - - 1978
In normal rats, glomerular plasma flow rates (GPF) were estimated from the uptake of microspheres, and single-nephron filtration rates were estimated by Hanssen's technique in order to calculate single-nephron filtration fractions (SNFF) for outer (C1), middle, (C2), and deep (C3) nephrons. With large microspheres (15 micron), SNFF averaged 0.19, 0.41, ...
Sabto J - - 1978
1. Radioactively labelled microspheres were used to determine glomerular blood flow in glomerular populations with distinct vascular characteristics. Two batches of microspheres (15 +/- 5.0 micrometer diameter and 7.0--10 micrometer diameter) were utilized. 2. The results show that the larger microspheres overestimate the superficial glomerular blood flow (414 +/- 61 ...
Bull R W - - 1978
The relationships between immune reactivity after blood transfusions, subsequent kidney allograft survival, and donor selection were studied in dogs. Animals with a high as well as low serological immune reactivity toward antigens contained in blood transfusion were observed. Genetic control of this reactivity or a linkage of this property to ...
Riley A L - - 1978
1. The effect of infusion of ovine prolactin was studied in anaesthetized dogs pretreated with bromocryptine to reduce the release of endogenous prolactin. 2. Prolactin, injected intravenously and also directly into one kidney, resulted in a 12--18% increase in glomerular filtration rate (GFR) by both kidneys. 3. This increased GFR ...
Wilkinson S P - - 1978
1. The spectrum of transit times of sodium o-iodohippurate (Hippuran) through the kidney can be derived from an 131I- (or 123I-) labelled Hippuran renogram by deconvolution. In the rabbit and pig, as has previously been shown in man, the frequency distribution curve for the transit times was bimodal. Since the ...
Fejes-Tóth G - - 1978
The purpose of the present study was to reexamine the effect of antidiuretic hormone (ADH) and indomethacin (IM) on intrarenal blood flow distribution by applying the microsphere technique to trained consciuous dogs. ADH and IM were given separately and jointly during maximal water diuresis. ADH in itself caused moderate antidiuresis ...
Stradling G N - - 1978
A major factor influencing the movement of plutonium-238 from the lungs to blood after the intubation of oxide suspensions is the presense of 0.001 micrometer diameter particles. In a polydisperse suspension of particles this fraction increases with time, due it is thought, to fragmentation of larger particles induced by alpha ...
Hendler N H - - 1978
Central nervous system effects have been demonstrated for angiotensin II and suggested for aldosterone. In order to determine whether either of these chemicals naturally crosses the blood-brain barrier, radioactive aldosterone and angiotensin II were introduced via intracardiac injections in rats. Samples of blood, liver, kidney, adrenals, cerebral cortex, and hypothalamus ...
Braun J P - - 1978
Gamma-glutamyl transferase distribution was studied in 10 ewes and 10 lambs; in both groups kidney was the most active organ, followed by pancreas, liver and lungs. In kidney and liver, GGT was bound mainly to cellular structures. Blood GGT activity of 48 lambs was 44 +/- 11 iu/litre and 33 ...
Iaina A - - 1978
The spontaneous changes in renal plasma flow (RPF) were determined by sodium paraamino hippurate clearance (CPAH) in the individual kidneys of 71 patients with essential and secondary hypertension. These changes were expressed as changes in CPAH and as changes in CPAH per 100 ml Glomerular Filtration Rate (GFR = inulin ...
Schmitz-Feuerhake I - - 1978
Non-invasive measurement of organ blood flow can be achieved by tracing the elimination patterns of 133Xe administered by inhalation. An adaption of the method for the estimation of renal blood flow was developed. The 133Xe is accumulated in the tissue by re-breathing for 1 min and the time course of ...
Weinstein S W - - 1978
Silicone rubber injections of methyl salicylate-cleared rat kidneys were performed. In 50 of 56 injections of superficial nephrons with their accompanying blood supply, the efferent vessel and early proximal tubule were closely approximated. In 18 of 21 tubular injections filling through the pars recta, the proximal tubule folded upon itself ...
Olsen U B - - 1978
100 ng/kg/min bradykinin was infused into the left renal artery in anaesthetized dogs which were loaded with 10% mannitol in saline to produce a diuresis of approximately 1 ml/min. Bradykinin initially increased renal blood flow (70%), kidney volume (20%). Kidney volume, diuresis and urine osmolarity remained equally changed during continuous ...
Szöcs E - - 1978
Kidney weight and renal functional parameters were investigated in dogs 7 to 68 days after uninephrectomy. Average enlargement of the remaining kidney amounted to 35.1%. Renal blood flow (RBF) and glomerular filtration rate (GFR) calculated per 100 g actual kidney weight were identical in the non-hypertrophied controls and in the ...
de Haas G - - 1978
Measurement of the spatial distribution of the clearance rate of xenon-133 from the kidney after its injection into the renal artery for estimating intrarenal blood flow can easily be combined with selective X-ray angiography as a routine method. Using a gamma camera as detection equipment anand applying a special computer ...
van Herk G - - 1978
A new method has been developed for the continuous quantification of kidney blood flow, utilizing the unique physical and biological properties of the radioactive tracer couple: rubidium-81/krypton-81m. After intravenous injection, 81Rb concentrates primarily in the kidneys, where it continuously generates the radioactive inert gas 81mKr. This ultrashort-lived isotope is continuously ...
Francová V - - 1978
In experiments on H mice and Wistar rats it was found that radioactivity was excreted after subcutaneous injection of Damvar-14C preponderantly in urine, and after oral administration, in faeces. After subcutaneous injection the urinary excretion set on very fast. After subcutaneous injection of Damvar-14C to H mice with Crocker's ascitic ...
László K - - 1978
Renal functional parameters were investigated prior to and following release of 24 hr unilateral ureteral ligation (UUL). In the obstructd kidney renal blood flow (RBF) and glomerular filtration rate (GFR) decreased to about 50% and 14%, respectively, as compared to normal controls. Relief of the obstruction did not cause any ...
Sampson D - - 1978
One hundred machine-preserved cadaver kidneys were transplanted irrespective of their flow rates on the preservation machine. Twenty-five per cent had flows of below 100 ml/min and 11 per cent had flows of below 80 ml/min. There was no correlation between the flow rate and function at 1, 3 or 12 ...
Gerber J G - - 1978
Sodium arachidonate, 10(-5) g/kg per minute, was infused into the renal artery of a nonfiltering canine kidney in situ in order to determine the effects of enhanced prostaglandin synthesis on renal blood flow and its distribution in circumstances where prostaglandins produced in the medulla could not gain access to the ...
Franke H - - 1978
The effect of an artificial O2 carrier (emulsion of the perfluorochemical FC43 with Pluronic-F-108) on the functional capability of the isolated perfused rat kidney was tested. In control series hydroxyethyl starch (HES) instead of fluorocarbon was used. Improving O2 supply in FC 43 experiments raised Na reabsorption to 149 mumol/g ...
Chen D S - - 1977
Collection of urine in rabbits by conventional methods such as catheterization of ureters or bladder with polyethylene tubing or Foley cannulas is hampered by the occurrence of hematuria or obstruction of urine flow, or both. These problems were solved by placing in the bladder a stainless steel device with a ...
Johnston W H - - 1977
The purpose of these experiments was to define changes in glomeruli of rats kidneys which could account for a marked reduction of blood flow immediately following temporary ischemia. After the renal artery had been clamped for 60 minutes, mesangial and endothelial cellular swelling was sufficiently severe to compress and trap ...
Schnermann J - - 1977
Micropuncture studies were done in isolated, blood-perfused dog kidneys to investigate the intrarenal nature of tubuloglomerular feedback regulation of nephron filtration rate. Collections were made at early proximal tubular sites during alterations in flow through the loop of Henle to elicit the feedback response. Renal blood flow in the 10 ...
Banks R O - - 1977
The present study examined intrarenal blood flow distribution and possible involvement of tubular elements in rats with aminonucleoside (AMN)-induced nephrotic syndrome. Tubular maxima of para-aminohippurate (T M PAH) were determined during mild saline expansion in control rats and in rats on days 4, 5, 6, and 14 following a single ...
Bartlett G R - - 1977
A study was made of the metabolism by the rabbit of adenine administered intravenously at a dose of 35 mg/kg with 100 micronCi of 8-14C-adenine. The infused adenine was removed from the blood in two phases, first by diffusion into the tissues and second by metabolic reactions throughout the body. ...
Gaber H - - 1977
2-Dimethylamino-4-(N-methylanilino)-phenol (MP), an active metabolite of N,N-dimethylaniline-N-oxide in the autocatalytic formation of ferrihemoglobin, reacted quickly in dogs after intravenous injection. A dose of 14C-labeled MP which oxidized 40% of the hemoglobin disappeared from the blood in 20 min. During this period of time MP transferred catalytically electrons from ferrohemoglobin to ...
Assailly J - - 1977
A noninvasive method for measurement of the individual kidney filtration fraction (FF) is presented, based on an analysis of the early rise of the kidneys' time-activity curves obtained after simultaneous injection of tubular [131I] ortho-iodohippurate and glomerular (Tc-99m DTPA) tracers. The analysis is based on the assumption that an insignificant ...
Schnermann J - - 1977
Microperfusion experiments were performed in rats to assess the effect of luminal application of theophylline and the more lipophilic 3-isobutyl-1-methylxanthine (IBMX) on feedback regulation of glomerular filtration rate. Elevation of loop of Henle flow from 0 to 40 nl/min caused a 20.3 +/- 4.5% reduction of stop flow pressure (SFP) ...
Clausen G - - 1977
Paired hydronephrotic (HN) and hypertrophic (HT) rat kidneys were studied after 6 days with complete unilateral ureteral obstruction without exposing the kidneys. Total HN renal blood flow (RBF), estimated by total microsphere (MS) uptake and from local 125I-antipyrine (Ap) uptake, averaged about 3/4 of control. HN kidney GFR was reduced ...
Constantinou C E - - 1977
Temporal and distributive properties of ureteral peristaltic contractions in the anesthetized pig have been examined. Interperistaltic time intervals have been recorded, and their frequency during different urine flow rates has been compared. The results show that ureteral peristalsis is increased at high urine flow rates to a maximum of approximately ...
Vandongen R - - 1977
1. Intrarenal infusion of frusemide markedly stimulated renin secretion in the isolated perfused kidney of the rat. 2. Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding ...
Cramer B M - - 1977
Using direct cannulation of renal lymphatic vessels and simultaneous photography of the exposed dog kidney during urography, the time schedule of variations in lymph flow and kidney size was established. The intravenous contrast injection produced heavy increase of renal lymph flow during the first 8 minutes of urography. Peak values ...
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