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Davis J M JM Department of Chemical Engineering, University of Massachusetts, Amherst, MA , 01003, USA, - - 2014
Numerical simulations of unsteady blood flow through a honeycomb network originating at multiple inlets and terminating at multiple outlets are presented and discussed under the assumption that blood behaves as a continuum with variable constitution. Unlike a tree network, the honeycomb network exhibits both diverging and converging bifurcations between branching ...
Ardin Sergey S Transfusion Medicine, University Hospital of Cologne, Cologne, - - 2014
To prevent phlebotomy of anemic individuals and to ensure hemoglobin (Hb) content of the blood units, Hb screening of blood donors before donation is essential. Hb values are mostly evaluated by measurement of capillary blood obtained from fingerstick. Rapid noninvasive methods have recently become available and may be preferred by ...
Lippi G G Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, - - 2014
We aimed to identify simple but reliable indices for effective screening of spurious hemolysis in whole-blood specimens. Thirteen inpatient whole-blood samples were divided in two aliquots. The former was left untreated, whereas the latter was mechanically hemolyzed by forced aspiration with an insulin syringe. All aliquots were tested on Siemens ...
de Rezende Marina Mastelaro MM Laboratório de Erros Inatos do Metabolismo, Department of Psychobiology, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, 3rd Floor, 04024-002 São Paulo, SP, Brazil. Electronic address: - - 2014
Mucopolysaccharidosis II (MPS II), or Hunter Syndrome, is a lysosomal storage disorder that is caused by the deficiency or absence of iduronate-2-sulfatase (IDS) enzyme; in this disease, early diagnosis is essential to provide higher life expectancy for patients. This study validates a fluorimetric assay that is used to assess IDS ...
Pagliaro Pasqualepaolo P Immunohaematology and Transfusion Unit, S. Orsola-Malpighi Hospital, - - 2014
Assessing blood-donor haemoglobin (Hb) is a worldwide screening requirement against inappropriate donation. The pre-donation Hb (which should be at least 12.5 g/dL in women and 13.5 g/dL in men) is usually determined in capillary blood from a finger prick, using a spectrophotometer which reveals the absorbance of blood haemolysed in ...
Alghamdi Sarah S From the Departments of Pathology, - - 2014
The Blood Utilization Committee implemented a standardized protocol for the preoperative blood order for cardiac patients. The aim of our study was to assess the improvement in blood utilization using the crossmatch to transfusion ratio (C:T). Four months of retrospective data were collected, which included all RBC crossmatch requests and ...
Liang Xiaorong X Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, - - 2014
Background: NAD(+) is an endogenous analyte and is unstable during blood sample collection, both of which present obstacles for quantitation. Moreover, current procedures for NAD(+) sample collection require onsite treatment with strong acid to stabilize the NAD(+) in mouse blood cells. Results: NAD(+) can be stabilized by addition of acid ...
Moritz Erin D ED Scientific Support Office, American Red Cross, Gaithersburg, - - 2014
Babesia microti, a transfusion-transmissible intraerythrocytic parasite, is increasing in frequency in the United States with no available FDA-licensed donor screening assay. We utilized investigational arrayed fluorescence immunoassay (AFIA) and polymerase chain reaction (PCR) to detect B. microti antibodies and DNA in blood donors. AFIA and real-time PCR were performed on frozen ...
Torres Kátia Luz KL Fundação Centro de Controle de Oncologia do Amazonas, Manaus, AM, Brazil; Fundação Hospitalar de Hematologia e Hemoterapia, Manaus, AM, Brazil; Universidade Federal do Amazonas, Manaus, AM, Brazil. Electronic address: - - 2014
With 99% of the cases in Brazil, malaria is endemic in the Amazon region. Transfusion-transmitted malaria, an important risk in endemic areas, has been reported. The aim of this study was to describe the epidemiological profile of blood donor candidates at the Fundação de Hematologia e Hemoterapia do Amazonas and ...
Leuenberger Nicolas N Swiss Laboratory for Doping Analyses, University Center of Legal Medicine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University of Lausanne, - - 2014
Currently, there is no simple direct screening method for the misuse of blood transfusions in sports. In this study, we investigated whether the measurement of iron in EDTA-plasma can serve as biomarker for such purpose. Our results revealed an increase of the plasma iron level up to 25-fold 6 h after ...
Evans Carol C Department of Medical Biochemistry and Immunology, University Hospital of Wales, - - 2014
Population iodine status can be assessed by urinary iodine concentrations, prevalence of goitre, frequency of newborn thyroid-stimulating hormone (TSH) > 5 mU/L and blood thyroglobulin concentrations. The UK population has historically been considered to be iodine sufficient, however a recent survey of UK schoolgirls has demonstrated median urinary iodine concentrations ...
Ikoma Maura R V MR Hospital Amaral Carvalho, Laboratório de Citometria de Fluxo do Hemonúcleo Regional de Jau, São Paulo, - - 2014
Multiparameter flow cytometry is a highly sensitive, fast, and specific diagnostic technology with a wide range of applicability in hematology. Although well-established eight-color immunophenotyping panels are already available, most Brazilian clinical laboratories are equipped with four-color flow cytometer facilities. Based on this fact, the Brazilian Group of Flow Cytometry (Grupo ...
Kusk Maria Schioldan MS Paediatrics and Adolescent Medicine, The University Hospital Rigshospitalet, Copenhagen, - - 2014
The leukemia-associated ETV6-RUNX1-translocation frequently emerges prenatally. Reverse-transcriptase PCR screening may indicate presence of ETV6-RUNX1 transcripts in random cord blood samples. Subsequent cell enrichment validation finds significantly lower levels than validation applying fluorescence in situ hybridization (FISH) (<10(-5) vs. 10(-3) to 10(-4) ). Using three FISH probe sets, we screened 179,000 ...
Garg Neeraj N Department of Pathology, UCMS and GTB Hospital, Delhi, - - 2014
To evaluate the prevalence of the anti-red blood cell antibodies among healthy blood donors. Antibody screening of all voluntary blood donor serum was performed as routine immunohematological procedure. Positive sera were further investigated to identify the specificity of irregular erythrocyte antibody by commercially available red cell panel (ID-Dia Panel, Diamed-ID ...
Khan Usman A UA Section of Nephrology, Yale University School of Medicine, Veterans Affairs Medical Center, and the Program of Applied Translational Research, New Haven, - - 2014
Cardiac surgery is a major cause of acute kidney injury. In this setting, receipt of blood transfusions seems to be associated with a higher risk of acute kidney injury, as measured using serum creatinine values. We examined this association further by using urinary biomarkers of kidney injury. A total of ...
Ikoma Maura R V MR Hospital Amaral Carvalho - Jau, SP, - - 2014
Multiparameter flow cytometry (MFC) is a highly sensitive, fast and specific diagnostic technology with a wide range of applicability in hematology. Although well-established eight-color immunophenotyping panels are already available, most Brazilian clinical laboratories are equipped with four-color flow cytometer facilities. Based on this fact, the Brazilian Group of Flow Cytometry ...
Dingler Regina J RJ Department of Medicine and Epidemiology, 1320 Tupper Hall, School of Veterinary Medicine, University of California, Davis, - - 2014
We investigated the involvement of birds in the ecology of the western black-legged tick, Ixodes pacificus, and its associated zoonotic bacteria, Borrelia burgdorferi and Anaplasma phagocytophilum, at two interior coast-range study sites in northern California. Anaplasma phagocytophilum, the agent of granulocytic anaplasmosis (GA), and B. burgdorferi s.s., the agent of ...
Sonnleitner Sissy Therese ST Dr Gernot Walder GmbH, Außervillgraten, - - 2014
After malaria, babesiosis is the second most common transfusion-transmitted parasitic disease in the United States. In Europe, one reported transfusion case, concerning Babesia microti, occurred in Germany. Due to the fact that Babesia spp. are present in Tyrolean ticks, the aim of this study is to assess the occurrence of immunoglobulin ...
Delage G G Medical Affairs, Héma-Québec, Montreal, QC, - - 2014
Being notified of a false-positive infectious disease marker result can cause psychological distress in blood donors. A new notification process, informing donors of the possibility of re-entry, was compared with the previous one in which donors were indefinitely deferred to evaluate the mitigating effect on donors' psychological distress levels. Two ...
Fernando Sumadhya D - - 2014
Individuals with fever are screened for malaria in specially-established malaria diagnostic laboratories set up in rural hospitals in the Northern and Eastern Provinces of Sri Lanka. Large numbers of blood smears negative for malaria parasites are being screened daily. Good quality smears are essential to maintain a high diagnostic competency ...
Katz Lynn E LE GlaxoSmithKline, Respiratory, Research Triangle Park, North Carolina, United States ; - - 2014
Rationale: Measurement of sputum or blood eosinophils may allow identification of a severe eosinophilic asthma population responsive to mepolizumab. Objectives: The primary objective was assessment of a single blood eosinophil measurement to predict future eosinophil measurements in the following year versus using multiple blood eosinophil measurements. Additionally, we examined whether ...
Alizadeh Zahra Z 1)Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. 2)School of Allied Health Sciences, Tehran University of Medical Sciences, Tehran, - - 2014
Although serological screening tests for blood-borne hepatitis viruses have effectively reduced the risk of HBV transmission through transfusion of infected blood, there is still a possibility that infected blood units from occult carriers being released into the blood supply. The aim of this study was to determine the prevalence of ...
Freitas Daniel Roberto Coradi de DR Tropical Medicine Center, Universidade de Brasília, Brasília, DF, Brazil; National Agency for Health Surveillance (Anvisa), Brazil. Electronic address: - - 2014
Transfusion-transmitted malaria is a severe disease with high fatality rate. Most Brazilian blood banks in the Amazon region perform malaria screening using microscopic examination (thick smears). Since low parasite concentrations are expected in asymptomatic blood donors a high sensitivity test should be used for donor screening. This study determined the ...
Ries Jutta J Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, - - 2014
microRNAs (miRNAs) are aberrantly expressed in the whole blood of patients suffering from different types of cancer. Collection of whole blood samples is a minimally invasive procedure. To date, little is known concerning the altered miRNA expression in patients suffering from oral squamous cell carcinoma (OSCC). The present study aimed ...
Agrawal Amit A Blood Bank, Fortis Escorts Heart Institute, New Delhi, India. Electronic address: - - 2014
Pre-transfusion testing involves blood grouping (ABO and Rh) and major cross match (testing the recipient's serum/plasma against the donor's red blood cells) at 37°C to detect IgG antibodies. In the western countries, type and screen policy is routinely followed. This study was conducted to assess implementation of type and screen ...
Kong Fen-Ying FY School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, - - 2014
In this work, a convenient, fast, low cost, small sample volume and in situ detection of glucose in human whole blood has been developed by using a disposable screen-printed carbon electrode (SPCE) coupled with a paper disk. To perform the assay, the SPCE was modified with graphene/polyaniline/Au nanoparticles/glucose oxidase (Gr/PANI/AuNPs/GOD) ...
Wang Hye-Young - - 2014
Sepsis is one of the main causes of mortality and morbidity. The rapid detection of pathogens in blood of septic patients is essential for adequate antimicrobial therapy and better prognosis. This study aimed to accelerate the detection and discrimination of Gram-positive (GP) and Gram-negative (GN) bacteria and Candida species in ...
Fong Derek L DL Washington National Primate Research Center, University of Washington, Seattle, Washington, USA. - - 2014
A 2.25-y-old male pigtailed macaque (Macaca nemestrina) was experimentally irradiated and received a bone marrow transplant. After transplantation and engraftment, the macaque had unexpected recurring pancytopenia and dependent edema of the prepuce, scrotum, and legs. The diagnostic work-up included a blood smear, which revealed a trypomastigote consistent with Trypanosoma cruzi, ...
Agarwal Nitin N Department of Transfusion Medicine, IMA Blood Bank of Uttarakhand, Dehradun, - - 2014
An adequate, safe supply of blood and blood components is a crucial part of blood transfusion services. Blood donors with reactive screening test results are informed of their results by letter and telephone call, and are requested to come for counselling either at the blood centre or the integrated counselling ...
Gajjar Maitrey D MD Department of Immunohaematology and Blood Transfusion, B. J. Medical College and Civil Hospital, Ahmedabad, Gujarat, - - 2014
Hepatitis E virus (HEV) is emerging as a potential threat to blood safety after several cases of transmission by transfusion or transplantation have been described. Currently, blood donors in India are not screened for HEV. The studies conducted on HEV in recent times in India have focused on epidemiology and ...
Karmakar Prasanta Ray PR Associate Professor, Department of Community Medicine, R G Kar Medical College, Kolkata, West Bengal, - - 2014
Seroprevalence of transfusion transmissible infections (TTIs) among blood donors can be used to monitor the prevalence among apparently healthy adult population. The present study was conducted to determine the profile of blood donors and seroprevalence of TTI among them. Retrospective analysis of the donors of a blood bank attached with ...
Darshana Leeniyagala Gamaralalage Thamal LG Medical Laboratory Sciences Unit, Department of Allied Health Sciences, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda 10250, Sri - - 2014
This study was carried out to evaluate the diagnostic accuracy of WHO color scale in screening anemia during blood donor selection in Sri Lanka. A comparative cross-sectional study was conducted by the Medical Laboratory Sciences Unit of University of Sri Jayewardenepura in collaboration with National Blood Transfusion Centre, Sri Lanka. ...
Nuinoon Manit M 0000-0002-1325-5489 School of Allied Health Sciences and Public Health, Walailak University, Nakhon Si Thammarat 80161, - - 2014
Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood donors. This study was aimed at determining the frequency of α-thalassemia 1 trait, ...
Pennings Jeroen L A JL 0000-0002-9188-6358 Centre for Health Protection (GZB), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The - - 2014
We compared how measurements of pregnancy-associated plasma protein A (PAPP-A) and the free beta subunit of human chorionic gonadotropin (fβ-hCG) in maternal blood are influenced by different methods for blood collection, sample matrix, and immunoassay platform. Serum and dried blood spots (DBS) were obtained by venipuncture and by finger prick ...
Halliez Sophie S INRA (Institut National de la Recherche Agronomique), UR892, Virologie Immunologie Moléculaires, Jouy-en-Josas, - - 2014
Prion transmission can occur by blood transfusion in human variant Creutzfeldt-Jakob disease and in experimental animal models, including sheep. Screening of blood and its derivatives for the presence of prions became therefore a major public health issue. As infectious titer in blood is reportedly low, highly sensitive and robust methods ...
Störmer Melanie M Institut für Transfusionsmedizin, Blutspendezentrale, Universitätsklinikum Köln, Bad Oeynhausen, - - 2014
Bacterial contamination of blood components and the prevention of transfusion-associated bacterial infection still remains a major challenge in transfusion medicine. Over the past few decades, a significant reduction in the transmission of viral infections has been achieved due to the introduction of mandatory virus screening. Platelet concentrates (PCs) represent one ...
Nansseu Jobert Richie - - 2013
The transmission of malaria by blood transfusion was one of the first recorded incidents of transfusion-transmitted infections (TTIs). Although the World Health Organization (WHO) recommends that blood for transfusion should be screened for TTIs, malaria screening is not performed in most malaria-endemic countries in sub-Saharan Africa (SSA). The transfusion of ...
Vollmer Tanja - - 2013
Platelet concentrates (PCs) are the major source of transfusion-transmitted bacterial infection but the significantly higher number of transfused red blood cells (RBCs) has resulted in a similar occurrence of possible transfusion-associated bacterial infections as those of recipients transfused with platelets. The aim of this study was adaption of the BactiFlow ...
Kleinman Steven S Department of Pathology, University of British Columbia, Victoria, British Columbia, - - 2014
The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute. The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct ...
Birjandi Fariba - - 2013
Donor selection is still being emphasized, even in the era of sensitive laboratory screening. Therefore, a number of volunteers are deferred from blood donation. This study evaluated the deferral rate in Iran, as well as the frequency of each reason in order to monitor the impact of donor selection process ...
Renzaho Andre M N - - 2013
The risk factors associated with the use of glucose-6-phosphate dehydrogenase (G6PD)-deficient blood in transfusion have not yet been well established. Therefore, the aim of this review was to evaluate whether whole blood from healthy G6PD-deficient donors is safe to use for transfusion. The study undertook a systematic review of English ...
Elmonem Mohamed A - - 2013
This study aimed to evaluate the agreement between blood spot and plasma chitotriosidase using the economic substrate 4-methylumbelliferyl-β-D-N,N´,N˝-triacetylchitotrioside, and to investigate the utility of the blood spot assay for the wide scale screening for lysosomal storage disorders among the clinically suspected. Blinded blood spot samples were compared with the corresponding ...
Lim Shaun W - - 2013
The detection and sorting of aqueous drops is central to microfluidic workflows for high-throughput biology applications, including directed evolution, digital PCR, and antibody screening. However, high-throughput detection and sorting of drops require optical systems and microfluidic components that are complex, difficult to build, and often yield inadequate sensitivity and throughput. ...
Maffi D - - 2013
In the countries with high G6PD deficiency prevalence, blood donors are not routinely screened for this genetic defect. G6PD deficiency is often asymptomatic, blood donors may be carriers of the deficiency without being aware of it. The aim of the study was to evaluate the prevalence of G6PD deficiency among ...
Sousa Ana C A - - 2013
Pet cats and dogs have been successfully used as indicators of environmental pollution by a great variety of chemicals, including metals. However, information on mercury (a well know priority environmental pollutant) concentrations in household pets tissues and/or organs is scarce. Thus, in the present work we quantified total mercury (HgTotal) ...
Gabrielli Simona - - 2013
Chagas disease is a parasitic disease due to Trypanosoma cruzi, endemic in Central and Southern America, where the protozoon infects about 8-10 million people. In rural areas the infection is acquired mostly through reduviidae insect vectors, whereas in urban ones it is acquired mainly through the transfusion of blood products, ...
Bhang Dong Ha - - 2013
A 12-year-old spayed female mixed-bred dog presented with nasal bleeding of 2 days duration and a skin nodule in the left flank. No abnormalities were found in coagulation profiles and blood pressure. Cytological evaluation of the nodule revealed numerous characteristic round organisms having a nucleus and a bar within macrophages ...
Cottrell Susan - - 2013
This systematic review addresses the issue of wrong blood in tube (WBIT). The objective was to identify interventions that have been implemented and the effectiveness of these interventions to reduce WBIT incidence in red blood cell transfusion. Eligible articles were identified through a comprehensive search of The Cochrane Library, MEDLINE, ...
Rudolf-Oliveira Renata Cristina Messores - - 2013
Portable hemoglobinometers are used to determine hemoglobin level, but there are conflicting reports regarding their accuracy. The aim of this study was to compare results from two portable hemoglobinometers (HemoCue® and Hemo-Control) with an automated hematology analyzer (Sysmex XE-2100D) to determine if the screening of blood donors is reliable. A ...
Hoyt Nathan - - 2013
Abstract The U.S. Department of Defense is using the chemicals 2,4-dinitroanisole (DNAN) and 3-nitro-1, 2,4-triazol-5-one (NTO) in new munitions development. In a screen for biomarkers of exposure, these compounds were measured in urine and blood of male rhesus monkeys after oral doses. NTO peaked at 4 h, with urinary concentrations at ...
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