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Louis Elan D - - 2013
Parkinson's disease (PD) is a late-life neurodegenerative disease. Genetic and environmental factors play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin that shows structural resemblance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In 2002 and 2007, we demonstrated elevated blood harmane concentrations [HA] in essential tremor (ET) cases. We now assessed whether ...
Bolat Ahmet A Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, - - 2013
The aim of this study was to investigate the changes in the peripheral blood of newborns of hypertensive mothers. The umbilical cord blood from newborns of 31 hypertensive mothers and 32 healthy mothers were examined. In all subjects, complete blood count, peripheral blood smear, reticulocyte count, vitamin B12, folate, ferritin ...
Fujishima Hiroshi - - 2013
Eosinophils appear to be key cells in the pathogenesis of conjunctival inflammation in atopic keratoconjunctivitis (AKC). Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) mediates prostaglandin D2 (PGD2)-dependent migration of eosinophils. However, it is unclear whether CRTH2/PGD2-dependent eosinophil migration is upregulated in allergic diseases. To compare the chemotactic responses ...
Pitini Vincenzo - - 2013
A previously healthy 14-years old male was admitted to hospital with a 10 day history of remittent fever. Physiscal examination showed moderate hepatosplenomegaly and generalized lymphadenopathy. Laboratory tests revealed AST 490 IU/L, ALT 596 IU/L, and pancytopenia (haemoglobin 101 g/l, WBC 2.1 x10(9) /l, platelets 86x10(9) /l). Morphologic examination of ...
Asenso-Mensah Kwame - - 2013
BACKGROUND: In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUDY DESIGN AND METHODS: Four areas were explored: circumstances ...
Schrag Anette E - - 2013
The neurobiological basis of psychogenic movement disorders remains poorly understood and the management of these conditions difficult. Functional neuroimaging studies have provided some insight into the pathophysiology of disorders implicating particularly the prefrontal cortex, but there are no studies on psychogenic dystonia, and comparisons with findings in organic counterparts are ...
Mast Alan E - - 2013
Dietary iron absorption is regulated by hepcidin, an iron regulatory protein produced by the liver. Hepcidin production is regulated by iron stores, erythropoiesis and inflammation, but its physiology has not been characterized when repeated blood loss occurs. Hepcidin was measured in plasma samples obtained from 114 first-time/reactivated (no blood donations ...
Fujiwara Keiko - - 2013
Since 1990, Boron Neutron Capture Therapy (BNCT) has been used for over 400 cancer patients at the Kyoto University Research Reactor Institute (KURRI). After BNCT, the patients are radioactive and their (24)Na and (38)Cl levels can be detected via a Na-I scintillation counter. This activity is predominantly due to (24)Na, ...
Robbins Amy Moorman - - 2013
Against previous critics' readings of Stein's Blood on the Dining-Room Floor as a failed attempt at the hard-boiled genre, this article argues for the many ways in which the novel re-writes the gothic/domestic detective story in a brilliant tour de force that frames all that is un-natural about heteronormative Victorian ...
Louis Elan D ED Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. - - 2013
Environmental correlates for essential tremor (ET) are largely unexplored. The search for such environmental factors has involved the study of a number of neurotoxins. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing toxin. In two prior case-control studies in New York, we demonstrated that blood harmane concentration was elevated in ET patients ...
Yu Xuerong - - 2012
ABSTRACT: Study Design. A retrospective cohort study.Objective. To identify predictors of massive blood loss after scoliosis surgery.Summary of Background. Scoliosis surgery may be associated with considerable blood loss. Many blood conservation techniques have been used to reduce the allogeneic transfusion. An ability to identify patients with high risk for massive ...
Mutzbauer Till S - - 2012
Impairment of Eustachian tube function has been observed after hyperbaric oxygen treatment as well as after diving on oxygen used as breathing gas. The aim of the present study was to evaluate the influence of hyperbaric oxygen exposure on Eustachian tube ventilatory function and airflow characteristics of the nose. Six ...
Lee K F KF Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, - - 2012
The intermittent Pringle manoeuvre (IPM) is commonly applied during liver resection. Few randomized trials have addressed its effectiveness in reducing blood loss and the results have been conflicting. The present study investigated the hypothesis that IPM could reduce blood loss during liver resection by 50 per cent. Between May 2008 ...
Anders Katherine L - - 2012
Non-invasive specimens for dengue diagnosis may be preferable where venous blood is difficult to collect and/or process, such as community-based or remote settings or when sampling from young children. We evaluated the performance of oral swabs and dried blood spots (DBS), compared with plasma, in diagnosing acute dengue and screening ...
Wang Shen-Chih - - 2012
Plasma-containing products are given during the preanhepatic stage of liver transplant surgery to correct abnormal Thromboeslastogram (TEG) values and prevent blood loss due to coagulation defects. However, evidence suggests that abnormal TEG results do not always predict bleeding. We questioned what effect using higher TEG values to initiate treatment would ...
Imai Norio - - 2012
In this study, we evaluated the hemostatic effects of tranexamic acid (TNA), an antifibrinolytic drug, by examining the timing of its administration during total hip arthroplasty. One hundred seven patients being treated for osteoarthritis of the hip joint were randomly divided into 5 groups based on the timing of TNA ...
Elsedeek Mervat S-E-A - - 2012
OBJECTIVE: To evaluate the effect of preoperative administration of rectal misoprostol on blood loss during and after elective cesarean delivery. METHODS: A randomized controlled trial was conducted among 400 women scheduled for elective cesarean delivery. The study group (n=200) received 400μg of misoprostol. The control group (n=200) received placebo. Study ...
Zhang Wenjing - - 2012
The microenvironment of the cochlea is maintained by the barrier between the systemic circulation and the fluids inside the stria vascularis. However, the mechanisms that control the permeability of the intrastrial fluid-blood barrier remain largely unknown. The barrier comprises endothelial cells connected to each other by tight junctions and an ...
Achavanuntakul Kajohn - - 2012
PURPOSE: To evaluate the effect of clinical and tumor factors on operative blood loss during open radical hysterectomy and pelvic lymphadenectomy for early-stage cervical cancer. METHODS: Clinical, pathological, and operative data of 456 women with cervical cancer stage IA2-IIA who had open radical hysterectomy with bilateral pelvic lymphadenectomy (RHPL) from ...
Scully Christopher G - - 2012
Background:We designed this study to determine if 900 mL of blood withdrawal during spontaneous breathing in healthy volunteers could be detected by examining the time-varying spectral amplitude of the photoplethysmographic (PPG) waveform in the heart rate frequency band and/or in the breathing rate frequency band before significant changes occurred in ...
Clavé A - - 2012
Perioperative blood loss is a frequent cause of complications in total hip replacement (THR). The present prospective study assessed the efficacy of tranexamic acid (Exacyl(®)) in reducing blood loss in primary THR associated to rivaroxaban (Xarelto(®)) thromboprophylaxis. Tranexamic acid associated to rivaroxaban reduces blood loss. A prospective case-control study included ...
Radovanovic Ingrid - - 2012
Currently, there is very limited literature on the effect of long-term anticoagulants on total knee arthroplasty. The primary purpose of this study was to determine the effect of warfarin and clopidogrel on the transfusion rate, intra-operative blood loss, and postoperative blood loss for total knee arthroplasty. The secondary purpose was ...
McNally Stephen J SJ Department of Clinical Surgery, University of Edinburgh, Edinburgh, UK. - - 2012
Excessive blood loss during liver surgery contributes to postoperative morbidity and mortality and the minimizing of blood loss improves outcomes. This study examines pre- and intraoperative factors contributing to blood loss and identifies areas for improvement. All patients who underwent elective hepatic resection between June 2007 and June 2009 were ...
Stahl D L - - 2012
Surgical blood loss predicts peri-operative outcomes. We have developed and validated Blood Loss Scores to estimate peri-operative blood loss during major abdominal surgery. Surgical blood loss and changes in haemoglobin concentration were recorded intra- and postoperatively for 48 h in 100 patients undergoing radical prostatectomy. Data from the first group ...
McConnell Jamie - - 2012
Perioperative blood loss was compared in 136 patients (2 groups of 68 patients) who underwent total knee arthroplasty (TKA). Blood loss was significantly lower when using a computer-navigated technique in comparison to a method employing intramedullary femoral rods. Total blood loss was calculated from body weight, height and haematocrit change, ...
Heerwagen Søren T - - 2012
Purpose: The purpose of this study was to investigate if the immediate hemodynamic outcome of an endovascular intervention on a dysfunctional hemodialysis arteriovenous fistula is a prognostic factor for primary patency. Methods: This was a prospective observational study including 61 consecutive patients with dysfunctional arteriovenous fistulas referred to our endovascular ...
Schmutzhard Joachim - - 2012
Experimental murine malaria has been shown to result in significant hearing impairment. Microscopic evaluation of the temporal bones of these animals has revealed regular morphology of the cochlea duct. Furthermore, the known vascular pathologic changes being associated with malaria could not be found. Immunohistochemistry for ICAM1 showed a strong marking ...
Peach G - - 2011
INTRODUCTION: Kinking and endofibrosis of the iliac arteries are uncommon and poorly recognized conditions affecting young endurance athletes. Deformation or progressive stenosis of the iliac artery may reduce blood flow to the lower limb and adversely affect performance. The aim of this review was to examine the existing literature relating ...
Godin Gaston - - 2011
Findings about the efficacy of interventions promoting blood donation are scattered and sometime inconsistent. The aim of the present systematic review was to identify the most effective types of interventions and modes of delivery to increase blood donation. The following databases were investigated: MEDLINE/PubMed, PsycINFO, CINAHL, EMBASE, and Proquest Dissertations ...
Zhang Haoran - - 2011
PURPOSE: Studies have shown that tranexamic acid (TXA) reduces blood loss and transfusion need in patients undergoing total knee arthroplasty (TKA). However, no single study has been large enough to definitively determine whether the drug is safe and effective. We report a systematic review and meta-analysis of randomised controlled trials ...
Wikkelsoe A J - - 2011
Thrombelastography (TEG) and Thrombelastometry (ROTEM) are viscoelastic whole-blood assays evaluating the haemostatic capacity of blood. These devices are used in algorithms to guide transfusion of haemostatic blood components. The methods used for this study were systematic reviews with meta-analyses and trial sequential analyses of randomised clinical trials (RCTs) of TEG/ROTEM-based ...
Holly Crystal D - - 2011
BACKGROUND: Despite the ongoing need for blood donation, few people give blood. A common reason is concern about vasovagal symptoms. PURPOSE: The aim of this study was to evaluate the effectiveness of applied tension in reducing vasovagal symptoms during blood donation and the mechanisms of action. METHOD: Two hundred eighty-two ...
Kang Hyung-Kyu HK Department of Physical Therapy, The Graduate School, Sahmyook University, Seoul, Republic of - - 2012
This study examined the effects of treadmill training with optic flow on the functional recovery of balance and gait in stroke patients. Randomized controlled experimental study. Thirty patients following stroke were divided randomly into the treadmill with optic flow group (n = 10), treadmill group (n = 10) and control group (n = 10). The subjects ...
Mohandas Anita - - 2011
: Many different methods are used to manage surgical bleeding and reduce transfusion. Techniques vary by institution, resulting in inconsistent outcomes. We reviewed the current literature on the quality and costs of transfusions, focusing on prevention and management of transfusions during surgery, and provide recommendations on future directions for quality ...
Wagner Jason M - - 2011
OBJECTIVE: The objective of our study was to determine whether pleural blood patching reduces the need for chest tube placement and hospital admission for pneumothorax complicating CT-guided percutaneous lung biopsy. MATERIALS AND METHODS: We reviewed 463 CT-guided lung biopsies performed between August 2006 and March 2010 to determine whether intervention ...
Almeida Quincy J - - 2012
Visual cues are known to improve gait in Parkinson's disease (PD); however, the contribution of optic flow continues to be disputed. This study manipulated transverse line cues during two gait training interventions (6 weeks). PD subjects (N = 42) were assigned to one of three groups: treadmill (TG), overground (OG), ...
Undar A - - 2011
This review on the benefits of pulsatile flow includes not only experimental and clinical data, but also attempts to further illuminate the major factors as to why this debate has continued during the past 55 years. Every single component of the cardiopulmonary bypass (CPB) circuitry is equally important for generating ...
Koster J - - 2011
Objectives: This study was conducted in Bamenda, Cameroon. The objectives of the study were to develop a theoretical framework to better understand local attitudes towards blood donation and transfusion, to identify factors that motivate and deter blood donation and to identify interventions to improve the supply of blood for transfusion ...
Wecht Jill M - - 2011
Wecht JM, Radulovic M, Rosado-Rivera D, Zhang RL, LaFountaine MF, Bauman WA. Orthostatic effects of midodrine versus L-NAME on cerebral blood flow and the renin-angiotensin-aldosterone system in tetraplegia. OBJECTIVE: To compare responses to head-up tilt (HUT) in individuals with chronic tetraplegia after midodrine hydrochloride (10mg) versus nitro-L-arginine methyl ester (L-NAME, ...
Godin Gaston - - 2011
BACKGROUND: A strategy used by blood centers to retain donors is to place phone call reminders. However, among first-time donors, no studies have tested the effect of this strategy. This was the aim of this study among individuals who had recently given their first lifetime blood donation. STUDY DESIGN AND ...
Wieling Wouter - - 2011
Vasovagal syncope (VVS) is a consistent, but infrequent (0.1%-0.3%) complication of volunteer, whole blood donation. Given the large number of blood donations, a significant number of donors is involved. Syncope occasionally leads to injury. Recent rigorous data collection and analysis have led to the association of a small number of ...
Trefry Michael G - - 2011
Many intervention activities in the terrestrial subsurface involve the need to recover/emplace distributions of scalar quantities (e.g. dissolved phase concentrations or heat) from/in volumes of saturated porous media. These scalars can be targeted by pump-and-treat methods or by amendment technologies. Application examples include in-situ leaching for metals, recovery of dissolved ...
Verlicchi Franco - - 2011
Previous studies have shown the usefulness of combining information from different data sources to identify and analyse variations in transfusion practices. Good knowledge of the conditions leading to blood use is a fundamental requirement for the assessment of the appropriateness of blood transfusion. In this study we combined blood transfusion ...
Kimura Noriyuki - - 2011
Thyrotropin releasing hormone (TRH) improves cerebellar ataxia and cerebellar perfusion in patients with spinocerebellar degeneration. It is not known whether TRH therapy can improve the cerebellar regional cerebral blood flow (rCBF) or not in patients with cerebellar variant of multiple-system atrophy (MSA-C). Seven patients with MSA-C received TRH intravenously (2 ...
Kasperek Regina - - 2011
The release of diclofenac sodium and papaverine hydrochloride from tablets and pellets using the flow-through cell apparatus was studied. The influence of excipients and of a size of the solid dosage forms on the amount of the released substances at the intervals of time using the different rates of flow ...
Waldegrave Elizabeth - - 2011
An 81-year-old man presented to accident and emergency with a recent history of rapidly progressive bilateral hearing loss. Further questioning revealed recent sinusitis, fevers and general malaise. Initial bloods showed raised inflammatory markers, raised creatinine, low albumin and urine dip was positive for blood and protein. Chest x-ray showed faint ...
Pietersz R N I - - 2011
The aim of this article is to reflect on the historical background on what urged the authors in the 1980s to investigate the prolonged storage of whole blood at ambient temperature before component preparation, the routine implementation of the method in the Netherlands, and the effect on logistics and plasma ...
Frampton I - - 2011
Previous studies have demonstrated localised abnormalities of cerebral blood flow in anorexia nervosa, suggesting reduction of cerebral activity and function in specific regions. There is debate as to whether such findings are secondary to starvation or indicative of a primary abnormality predating the illness, representing an underlying biological substrate. This ...
Moutzouri Elisavet - - 2010
The renin angiotensin aldosterone system (RAAS) has been implicated in the pathogenesis of cerebrovascular diseases. During the past three decades, RAAS has gained attention as an important therapeutic target in cardiovascular medicine. Modulation of the RAAS for primary and secondary stroke prevention seems an appealing strategy. Several experimental studies have ...
Kishimoto Yuki - - 2010
Repetitive questioning is among the most common and burdensome of the behavioral and psychological symptoms of Alzheimer's disease (AD). Regardless of the clinical significance of the repetitive questioning, the neural substrates involved remain unclear. Fifty-eight consecutive patients with AD participated in this study. The score of repetitive questioning behavior was ...
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