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Redford Daniel D From the *Department of Anesthesiology, University of Arizona Medical Center, Tucson, Arizona; and †Masimo Corporation, Irvine, - - 2014
Traditional patient monitoring may not detect cerebral tissue hypoxia, and typical interventions may not improve tissue oxygenation. Therefore, monitoring cerebral tissue oxygen status with regional oximetry is being increasingly used by anesthesiologists and perfusionists during surgery. In this study, we evaluated absolute and trend accuracy of a new regional oximetry ...
Deleuran Ida I Centre for Medical Science and Technology Studies, Department of Public Health, University of Copenhagen, Denmark - - 2014
The existing literature on donor screening in transfusion medicine tends to distinguish between social concerns about discrimination and medical concerns about safety. In this article, we argue that the bifurcation into social and medical concerns is problematic. We build our case on a qualitative study of the historical rise and ...
Cieri Robert L RL Department of Biology, University of Utah, Salt Lake City, UT 84112; - - 2014
The generally accepted framework for the evolution of a key feature of the avian respiratory system, unidirectional airflow, is that it is an adaptation for efficiency of gas exchange and expanded aerobic capacities, and therefore it has historically been viewed as important to the ability of birds to fly and ...
Lonser Russell R RR Department of Neurological Surgery, Ohio State University Wexner Medical Center, Columbus, - - 2014
Convection-enhanced delivery (CED) is a bulk flow-driven process. Its properties permit direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while bypassing the blood-brain barrier. Development of surrogate imaging tracers that are co-infused during drug delivery now permit accurate, noninvasive real-time tracking of convective infusate flow in nervous system ...
Lippi Giuseppe G Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy - - 2014
We planned an original study to investigate the morphological changes caused by spurious hemolysis of whole-blood samples, analyzed using an automated image analysis system. Seven whole-blood specimens anticoagulated with EDTA were pooled and divided in two aliquots. The former was left untreated, whereas the latter was subjected to mechanical hemolysis ...
Fujii Yutaka Y Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan, - - 2014
Extracorporeal circulation (ECC) is indispensable for cardiac surgery. Despite the fact that ECCcauses damage to blood components and is non-physiologic, its pathophysiology has not been fully elucidated. This is because difficulty in clinical research and animal experiments keeps the knowledge insufficient. Therefore, it is desirable to have a miniature ECC ...
Go Young-Mi YM Emory University School of - - 2014
Disturbed blood flow (d-flow) occurring in branched and curved arteries promotes endothelial dysfunction and atherosclerosis, in part by altering gene expression and epigenomic profiles in endothelial cells. While a systemic metabolic change is known to play a role in atherosclerosis, it is unclear whether it can be regulated by local ...
Dietzen Dennis J DJ Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA Core Laboratory, St. Louis Children's Hospital, St. Louis, MO, USA - - 2014
Hypoglycemia in infants is common, is difficult to recognize, and may lead to permanent neurologic impairment. Low glucose concentrations and high hematocrits in newborns pose significant analytic challenges for whole blood glucose meters. Three Bayer glucose monitoring systems were evaluated using 211 blood samples from 162 neonates (age range 5 ...
Li Cheng Guo CG Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea. - - 2014
Blood is the gold standard sample medium that can provide a wide variety of useful biological information for the diagnosis of various diseases. For portable point-of-care diagnosis, blood extraction systems have attracted attention as easier, safer, and more rapid methods of collecting small blood volumes. In this paper, we introduce ...
Lagerberg Johan W JW Blood Cell Research, Sanquin Research, Amsterdam, the - - 2014
The plasticizer di(2-ethylhexyl)phthalate (DEHP) is a common component in blood bags. DEHP is noncovalently bound to polyvinylchloride (PVC) polymer and can leach into the blood product. There are public concerns that exposure to DEHP might induce developmental and reproductive toxicity in humans. The aim of this study was to evaluate ...
Lehle Karla K Department of Cardiothoracic Surgery, University Medical Center Regensburg, 93042, Regensburg, - - 2014
Polymethylpentene membrane oxygenators used in venovenous extracorporeal membrane oxygenation (vvECMO) differ in their physical characteristics. The aim of the study was to analyze the gas transfer capability of different ECMO systems in clinical practice, as the choice of the appropriate system may be influenced by the needs of the patient. ...
Uchida Sae S Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan, - - 2014
This study aimed to examine the effect of acupuncture-like stimulation on cortical cerebral blood flow (CBF) in aged rats and the contribution of the intracranial cholinergic vasodilatory system on its response. In urethane-anesthetized rats of 30-37 months of age, manual acupuncture-like stimulation of a forepaw produced an increase in the CBF, ...
Shearmur Jeremy Frank JF School of Philosophy, RSSS, CASS, Australian National University, Canberra, ACT, 0200, Australia, - - 2014
If unremunerated blood donors are willing to participate, and if the use of them is economical from the perspective of those collecting blood, I can see no objection to their use. But there seems to me no good reason, moral or practical, why they should be used. The system of ...
Fardin Marc-Antoine MA Université de Lyon, Laboratoire de Physique, École Normale Supérieure de Lyon, CNRS UMR 5672, 46 Allée d' Italie, 69364 Lyon Cédex 07, - - 2014
We report on the recent progress made on flows of living polymer fluids. Such fluids have been model systems for rheological research for more than twenty years and they continue to be fascinating. Like most if not all soft matter systems, living polymers under flow show a strong feedback between ...
Finsterer Josef J Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Vienna, Austria, - - 2014
Most of the parasitoses manifest systemically, including the central nervous system (CNS). Among the most prevalent parasitoses in Central Europe (cysticercosis, toxocarosis, echinococcosis, and toxoplasmosis), cerebral involvement is well recognized and part of the clinical presentation, which cannot be neglected. CNS involvement results from invasion of larvae of these parasites ...
Adams Daniel L DL Beckman Vision Center, University of California, San Francisco, San Francisco, CA 94143, USA Center for Mind/Brain Sciences, The University of Trento, Trento, - - 2014
The vascular supply to layers and columns was compared in macaque primary visual cortex (V1) by labeling red blood cells via their endogenous peroxidase activity. Alternate sections were processed for cytochrome oxidase to reveal "patches" or "blobs," which anchor the interdigitated column systems of striate cortex. More densely populated cell ...
Keklik Muzaffer M Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, - - 2014
Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle plateletpheresis procedures of the three instruments were ...
Murray Katie N KN From the Faculty of Life Sciences (K.N.M., S.M.A.) and Centre for Imaging Science (L.M.P., S.R.W.), University of Manchester, Manchester, United Kingdom; Sainte-Justine Hospital Research Centre, University of Montreal, Canada (S.G.); Glasgow Experimental MRI Centre, The University of Glasgow, Glasgow, United Kingdom (W.M.H.); and University of Manchester, Manchester Academic Health Sciences Centre, United Kingdom - - 2014
Systemic inflammation contributes to diverse acute and chronic brain pathologies, and extensive evidence implicates inflammation in stroke susceptibility and poor outcome. Here we investigate whether systemic inflammation alters cerebral blood flow during reperfusion after experimental cerebral ischemia. Serial diffusion and perfusion-weighted MRI was performed after reperfusion in Wistar rats given ...
Emad Dehkordi S S Department of Land and Water Resources Engineering, Royal Institute of Technology (KTH), 100 44 Stockholm, - - 2014
The effect of array configuration, that is, number, layout, and spacing, on the performance of multiple borehole heat exchangers (BHEs) is generally known under the assumption of fully conductive transport. The effect of groundwater flow on BHE performance is also well established, but most commonly for single BHEs. In multiple-BHE ...
Taccone Fabio Silvio FS Department of Intensive Care, Erasmus Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium, - - 2014
Hemodynamic monitoring is widely used in critical care; however, the impact of such intervention in patients with acute brain injury (ABI) remains unclear. Using PubMed, a systematic review was performed (1966-August 2013), and 118 studies were included. Data were extracted using the PICO approach. The evidence was classified, and recommendations ...
Kato Takaumi T Graduate School of Biomedical Engineering, Tohoku University, Sendai, 980-8579, - - 2014
Prevention and early detection of atherosclerosis are critical for protection against subsequent circulatory disease. In this study, an automated two-dimensional ultrasonic-measurement-integrated (2D-UMI) blood flow analysis system for clinical diagnosis was developed, and the feasibility of the system for hemodynamic analysis in a carotid artery was revealed. The system automatically generated ...
Kishimoto Satoru S Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai Suita, Osaka, 565-8565, Japan, - - 2014
We developed a novel controller for a continuous-flow left ventricular assist device (EVAHEART) that can change the pump's rotational speed (RS) in synchronization with a patient's myocardial electrocardiogram (ECG) with the aim of facilitating cardiac recovery. We previously presented various applications of this system in animal models, but there remained ...
Hamlin Shannan K SK Nursing Research and Evidence-Based Practice, Houston Methodist Hospital, MGJ 11-017, Houston, TX 77030, USA. Electronic address: - - 2014
The cardiovascular system (macrocirculation) circulates blood throughout the body, but the microcirculation is responsible for modifying tissue perfusion and adapting it to metabolic demand. Hemodynamic assessment and monitoring of the critically ill patient is typically focused on global measures of oxygen transport and utilization, which do not evaluate the status ...
McBean Rhiannon S RS Research and Development, Australian Red Cross Blood Service, Brisbane, - - 2014
The number of blood group systems, currently 35, has increased in the recent years as genetic variations defining red cell antigens continue to be discovered. At present, 44 genes and 1568 alleles have been defined as encoding antigens within the 35 blood group systems. This paper provides a brief overview ...
Liu Xiao X Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, - - 2014
Helical flow in the human aorta is possibly a typical example of 'form follows function' in the vascular system. The helical blood flow may provide guaranties for the inner surface of the ascending aortic wall to get smooth and even washing by the blood so that atherosclerotic plaques can hardly ...
Nakada Tsutomu T Tsutomu Nakada, Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1-757 Asahimachi, Niigata, 951-8585, Japan, - - 2014
Recent studies have strongly indicated that the classic circulation model of cerebrospinal fluid (CSF) is no longer valid. The production of CSF is not only dependent on the choroid plexus but also on water flux in the peri-capillary (Virchow Robin) space. Historically, CSF flow through the Virchow Robin space is ...
Biscay Julien J Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, 33006 Oviedo, - - 2015
The use of the first flow-cell for magnetic assays with an integrated magnet is reported here. The flow injection analysis system (FIA) is used for biotin determination. The reaction scheme is based on a one step competitive assay between free biotin and biotin labeled with horseradish peroxidase (B-HRP). The mixture ...
Qiao Heyuan - - 2014
In the cryopreservation of blood, removing cryoprotectants from the cryopreserved blood safely and effectively is always being focused on. In our previous work, a dilution-filtration system was proposed to achieve the efficient clearance of cryoprotectants from the cryopreserved blood. In this study, a theoretical method is presented to optimize the ...
Arfvidsson Berndt - - 2014
Abstract Background: Our aim was to test the hypothesis that metabolic and inflammatory responses of the brain perioperatively during carotid endarterectomy (CEA) might affect blood brain barrier (BBB) integrity. Methods: Twenty patients with >70% stenosis of internal carotid artery (ICA) were prospectively included. Surgery was performed under general anaesthesia. Blood ...
Vahidnia Ali A Molecular Diagnostic Laboratory, Atal-Medial Medical Diagnostic Center, Jan Tooropstraat 138, 1061 AD, Amsterdam, the Netherlands. Electronic address: - - 2014
The purpose of this study is to introduce a high-throughput system, Aurora FLOW, for the simultaneous detection of 3 clinically relevant pathogens of sexually transmitted infections. Comparative evaluation with other systems revealed an overall concordance of 97.9% for Chlamydia trachomatis and comparable performance for Neisseria gonorrhoeae and Trichomonas vaginalis.
Kivirand K K Institute of Chemistry, University of Tartu, Ravila 14a, Tartu 50411, - - 2015
Responses of enzymatic bio-optrodes in flow regime were studied and an original model was proposed with the aim of establishing a reliable method for a quick determination of biosensor signal parameters, applicable for biosensor calibration. A dual-optrode glucose biosensor, comprising of a glucose bio-optrode and a reference oxygen optrode, both ...
Chang Jen-Yung JY Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University , Houghton Michigan 49931, - - 2014
An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface ...
Bilgili Mustafa Gökhan MG Department of Orthopedics and Traumatology, Bakırköy Dr. Sadi Konuk Research and Training Hospital, İstanbul, - - 2014
Blood loss and replacement is still a controversial issue in major orthopaedic surgery. Allogenic blood transfusion may cause legal problems and concerns regarding the transmission of transfusion-related diseases. Cellsaver Systems (CSS) were developed as an alternative to allogenic transfusion but CSS transfusion may cause coagulation, infection and haemodynamic instability. Our ...
Shou Dahua D Centre for Advanced Materials Technology (CAMT), School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, - - 2014
Transport in treelike networks has received wide attention in natural systems, oil recovery, microelectronic cooling systems, and textiles. Existing studies are focused on transport behaviors under a constant potential difference (including pressure, temperature, and voltage) in a steady state [B. Yu and B. Li, Phys. Rev. E 73, 066302 (2006); ...
Vayssade Anne-Laure AL Laboratoire Microfluidique, MEMs et Nanostructures, ESPCI ParisTech, UMR Gulliver 7083, ESPCI, CNRS, 10 Rue Vauquelin, 75005 Paris, - - 2014
We demonstrate that flows in confined systems are controlled by slip heterogeneities below a certain size. To show this we image the motion of soft glassy suspensions in microchannels whose inner walls impose different slip velocities. As the channel height decreases, the flow ceases to have the symmetric shape expected ...
Aalaei Shokoufeh S Student Research Committee, Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, - - 2014
Storage and transportation of red blood cells (RBCs) outside the standard temperature range as defined by guidelines can lead to hemolysis. One of the main factors believed to cause hemolysis is temperature.Infusion of the corrupted RBCs leads to haemolytic reactions which are severe and life-threatening. We developed a temperature monitoring ...
Slee Joshua B JB Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia; University of Pennsylvania Perelman School of - - 2014
The foreign body reaction occurs when a synthetic surface is introduced to the body. It is characterized by adsorption of blood proteins and the subsequent attachment and activation of platelets, monocyte/macrophage adhesion, and inflammatory cell signaling events, leading to post-procedural complications. The Chandler Loop Apparatus is an experimental system that ...
He Wenbo W School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an 710049, Shaanxi, - - 2014
Generating an artificial blood flow in a circle system is an important step in hemodynamic research; thus, the influence of circle system components on the pulsatile flow wave forms should be investigated. In this study, a circle system was built, in which two solenoid valves were controlled by a timer ...
Zhang Yang Y Department of Fluid Machinery and Engineering, Xi'an Jiaotong University, Xianning Western Road 28, Xi'an 710049, - - 2014
A novel Particle Tracking Velocimetry (PTV) algorithm based on Voronoi Diagram (VD) is proposed and briefed as VD-PTV. The robustness of VD-PTV for pulsatile flow is verified through a test that includes a widely used artificial flow and a classic reference algorithm. The proposed algorithm is then applied to visualize ...
Kolacinska Kamila K University of Warsaw, Department of - - 2014
This paper presents a simple, rapid and effective method for ammonia determination in a flow analysis regime using Nessler's reagent. The proposed modification of the common flow procedure results in the total elimination of the problem of precipitate deposition inside the flow manifold. The improved procedure has been adapted to ...
Gulati Gene G Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, PA - - 2014
To determine and optimize the sensitivity of the CellaVision DM96 automated image-analysis system in detecting platelet (PLT) clumps on blood smears and to assess the reliability of the traditional laboratory practice of examining only the feather edge of the smear for PLT clumps. We processed 102 blood smears that revealed ...
Khan Muhammad M 0000-0001-8807-2970 Department of Diabetes & Endocrinology, Countess of Chester Hospital NHS Foundation Trust, Chester CH2 1UL, - - 2014
Use of blood glucose (BG) meters in the self-monitoring of blood glucose (SMBG) significantly lowers the risk of diabetic complications. With several BG meters now commercially available, the International Organization for Standardization (ISO) ensures that each BG meter conforms to a set degree of accuracy. Although adherence to ISO guidelines ...
Hammel Jörg U JU Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich-Schiller-Universität Jena, Erbertstr. 1, 07743, Jena, - - 2014
Demosponges possess a leucon-type canal system which is characterized by a highly complex network of canal segments and choanocyte chambers. As sponges are sessile filter feeders, their aquiferous system plays an essential role in various fundamental physiological processes. Due to the morphological and architectural complexity of the canal system and ...
Louis Elan D - - 2013
Parkinson's disease (PD) is a late-life neurodegenerative disease. Genetic and environmental factors play an etiological role. Harmane (1-methyl-9H-pyrido[3,4-b]indole) is a potent tremor-producing neurotoxin that shows structural resemblance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In 2002 and 2007, we demonstrated elevated blood harmane concentrations [HA] in essential tremor (ET) cases. We now assessed whether ...
Bolat Ahmet A Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, - - 2013
The aim of this study was to investigate the changes in the peripheral blood of newborns of hypertensive mothers. The umbilical cord blood from newborns of 31 hypertensive mothers and 32 healthy mothers were examined. In all subjects, complete blood count, peripheral blood smear, reticulocyte count, vitamin B12, folate, ferritin ...
Fujishima Hiroshi - - 2013
Eosinophils appear to be key cells in the pathogenesis of conjunctival inflammation in atopic keratoconjunctivitis (AKC). Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) mediates prostaglandin D2 (PGD2)-dependent migration of eosinophils. However, it is unclear whether CRTH2/PGD2-dependent eosinophil migration is upregulated in allergic diseases. To compare the chemotactic responses ...
Pitini Vincenzo - - 2013
A previously healthy 14-years old male was admitted to hospital with a 10 day history of remittent fever. Physiscal examination showed moderate hepatosplenomegaly and generalized lymphadenopathy. Laboratory tests revealed AST 490 IU/L, ALT 596 IU/L, and pancytopenia (haemoglobin 101 g/l, WBC 2.1 x10(9) /l, platelets 86x10(9) /l). Morphologic examination of ...
Asenso-Mensah Kwame - - 2013
BACKGROUND: In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUDY DESIGN AND METHODS: Four areas were explored: circumstances ...
Kwak Rhokyun R Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, - - 2013
We consider electroconvective fluid flows initiated by ion concentration polarization (ICP) under pressure-driven shear flow, a scenario often found in many electrochemical devices and systems. Combining scaling analysis, experiment, and numerical modeling, we reveal unique behaviors of ICP under shear flow: a unidirectional vortex structure, its height selection, and vortex ...
Schrag Anette E - - 2013
The neurobiological basis of psychogenic movement disorders remains poorly understood and the management of these conditions difficult. Functional neuroimaging studies have provided some insight into the pathophysiology of disorders implicating particularly the prefrontal cortex, but there are no studies on psychogenic dystonia, and comparisons with findings in organic counterparts are ...
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