Search Results
Results 1 - 50 of 463
1 2 3 4 5 6 7 8 9 10 >
Midgett Madeline M Department of Biomedical Engineering and Knight Cardiovascular Institute, Center for Developmental Health, Oregon Health and Science University, 3303 SW Bond Avenue, CHH 13B, Portland, OR 97239, - - 2014
Altered blood flow during embryonic development has been shown to cause cardiac defects; however, the mechanisms by which the resulting haemodynamic forces trigger heart malformation are unclear. This study used heart outflow tract banding to alter normal haemodynamics in a chick embryo model at HH18 and characterized the immediate blood ...
Capron Thibaut T Aix-Marseille Université, UMR 7339, CNRS, CRMBM (Centre de Résonance Magnétique Biologique et Médicale), 13385, Marseille, - - 2014
Although arterial spin labeling (ASL) has become a routinely performed method in the rodent heart, its application to the human heart remains challenged by low tissue blood flow and cardiac and respiratory motion. We hypothesized that an alternative steady-pulsed ASL (spASL) method would provide more efficient perfusion signal averaging by ...
Fadel Bahaa M BM King Faisal Specialist Hospital & Research Center, Riyadh, Saudi - - 2014
The flow pattern in the hepatic veins (HVs) is dependent on the cardiac cycle and right heart hemodynamics and influenced by the respiratory cycle and the liver parenchyma. Most disease states that affect the right heart alter the HV Doppler in a manner independent of the respiratory cycle. Some diseases ...
Chasovskyi K K Perfusiology, Ukrainian Children's Cardiac Center, Kyiv, Ukraine - - 2014
This study evaluates the hemoglobin-oxygen relationship and tissue perfusion during cardiopulmonary bypass (CPB) in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components. We compared perioperative hematocrit (Hct), fetal hemoglobin (HbF), p50O2, pH, pCO2, serum lactate, duration of mechanical ventilation and intensive care unit (ICU) length ...
Punn Rajesh R All authors: Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital, Palo Alto, - - 2014
Currently, there are no established echocardiographic or hemodynamic predictors of mortality after weaning venoarterial extracorporeal membrane oxygenation in children. We wished to determine which measurements predict mortality. Over 3 years, we prospectively assessed six echo and six hemodynamic variables at 3-5 circuit rates while weaning extracorporeal membrane oxygenation flow. Hemodynamic ...
Salinas Manuel M Tissue Engineering, Mechanics, Imaging, and Materials Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL, - - 2014
Previous efforts in heart valve tissue engineering demonstrated that the combined effect of cyclic flexure and steady flow on bone marrow derived stem cell-seeded scaffolds resulted in significant increases in engineered collagen formation [Engelmayr et al. Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications ...
Fadel Bahaa M BM King Faisal Specialist Hospital & Research Center, Riyadh, Saudi - - 2014
Doppler interrogation of blood flow in the hepatic veins (HVs) is a part of any comprehensive echocardiographic examination. Data derived from the HV Doppler provide a useful tool for the assessment of right heart function. Beyond its dependence on the cardiac cycle, right heart hemodynamics, and compliance of the liver ...
Ritman Erik L EL Mayo Clinic College of Medicine - - 2014
During WW2 Earl Wood was charged with elucidating the biomedical factors in acceleration-induced loss of consciousness (G-LOC) experienced by pilots in high performance aircraft. For this he developed devices for measurement and recording of blood pressure and tissue blood content. Those data lead to the design and fabrication of successful ...
Andrikopoulos Georgios K GK Sotirios P Gartaganis, Georgios K Andrikopoulos, Department of Ophthalmology, University of Patras Medical School, 26504 Patras, - - 2014
Pseudoexfoliation (PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery. Apart from the long-known intraocular manifestations, PEX deposits have been found in a variety of extraocular locations and they ...
Dietrich Ann-Christin AC Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476 Potsdam, Germany; Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl-Neuberg Straße 1, 30625 Hannover, Germany; Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13125 Berlin, - - 2014
During heart development, the onset of heartbeat and blood flow coincides with a ballooning of the cardiac chambers. Here, we have used the zebrafish as a vertebrate model to characterize chamber ballooning morphogenesis of the endocardium, a specialized population of endothelial cells that line the interior of the heart. By ...
O'Brien K M KM University of Alaska Fairbanks, Institute of Arctic Biology, PO Box 757000, Fairbanks, AK 99775, USA. Electronic address: - - 2014
Creatine kinase (CK; EC 2.7.3.2) functions as a spatial and temporal energy buffer, dampening fluctuations in ATP levels as ATP supply and demand change. There are four CK isoforms in mammals, two cytosolic isoforms (muscle [M-CK] and brain [B-CK]), and two mitochondrial isoforms (ubiquitous [uMtCK] and sarcomeric [sMtCK]). Mammalian oxidative ...
Delorme Yann T YT School of Mechanical Engineering, Purdue University, Lafayette, IN, United - - 2014
Univentricular heart disease is the leading cause of death from any birth defect in the first year of life. Typically, patients have to undergo three open heart surgical procedures within the first few years of their lives to eventually directly connect the superior and inferior vena cavae to the left ...
Alizadeh Mansour M Department of Mechanical Engineering, Iran University of Science & Technology, Tehran, - - 2014
The purpose of this study is to investigate the hemodynamic parameters of blood flow in a balloon as a part of a new type of cardiac assist device named AVICENA, which is implanted into the descending aorta to improve the strength of pumping blood flow in a poor-performing left ventricle. ...
Tsounis Michael M Department of Otorhinolaryngology/Head and Neck Surgery (M.T.), Queen's Medical Centre, Nottingham, United - - 2014
The aim of this study was to ascertain the most reliable objective measurement for the assessment of nasal patency by investigating the relationship between peak nasal inspiratory flow, peak oral inspiratory flow, and the nasal patency index in relation to the patient's subjective perception regarding nasal obstruction. Prospective cohort study. ...
Kobayashi Yoshiki - - 2014
Objective: Most asthmatics have been found to have rhinosinusitis (RS). Patients with ethmoid sinusitis, in particular, often suffer from an impaired sense of smell; this is clinically important and necessitates concurrent treatment for both asthma and RS. As a rational therapeutic strategy, we focused on a fine particle HFA-134abeclomethasone dipropionate ...
Nobahar Mohammad Rezvan MR Department of Cardiac Anesthesia (Anesthesiology in Cardiac Surgery), Shahid Modares Hospital, Saadat Abad, Tehran, - - 2014
Acute normovolemic hemodilution (ANH) and preoperative autologous blood donation (PABD) have questionable efficacy, viral and bacterial infection risks, intermittent blood shortages as homeostasis problem, electrolyte and hemodynamic disturbances. In this cross sectional survey, we studied 70 patients undergoing open heart coronary artery bypass grafts [CABG] and different valvular replacement 1 ...
Ghezzi Chiara E CE Department of Mining and Materials Engineering, McGill University, Montreal, Quebec, Canada H3A - - 2014
Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airway smooth muscle cells. This ...
Zhao Kai K Monell Chemical Senses Center, Philadelphia, PA; Department of Otolaryngology, Thomas Jefferson University, Philadelphia, - - 2014
Nasal airflow is essential for the functioning of the human nose. Given individual variation in nasal anatomy, there is yet no consensus what constitutes normal nasal airflow patterns. We attempt to obtain such information that is essential to differentiate disease-related conditions. Computational fluid dynamics (CFD) simulated nasal airflow in 22 ...
Kirtsreesakul Virat V Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, - - 2014
Although nasal peak flow measurements have been proposed as a simple alternative method to assess nasal patency, which of nasal peak expiratory flow or nasal peak inspiratory flow (NPEF/NPIF) or the peak expiratory flow index or peak inspiratory flow index (PEFI/PIFI; the ratios between nasal and oral PEF or nasal ...
Hirose Kayo K Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate - - 2014
A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level ...
Wang Yong Y Department of Mechanical & Aerospace Engineering, University of California, Irvine, CA 92697, - - 2013
The fluid dynamical properties of the air flow in the upper airway (UA) are not fully understood at present due to the three-dimensional (3D) patient-specific complex geometry of the airway, flow transition from laminar to turbulent and flow-structure interaction during the breathing cycle. It is quite difficult at present to ...
Oreroğlu Ali Rıza AR Plastic Reconstructive and Aesthetic Surgery Department, Prof. Dr. A. İlhan Özdemir Giresun State Hospital, Atatürk Blvd. No. 323, 28100, Teyyaredüzü, Giresun, Turkey, - - 2013
The combination of dorsal nasal reconstruction and camouflage of surface irregularities is an important step in rhinoplasty. We hereby present our technique of delivering diced cartilage in combination with bone dust to the nasal dorsum using the patient's blood as a carrier. We advocate use of an autologous material (blood) ...
Miller Vincent J - - 2013
Traditionally, pausing chest compressions during airway management in a cardiac arrest has been the accepted norm. However, updated American Heart Association and the European Resuscitation Council guidelines for Advanced Cardiac Life Support emphasize reducing pauses in chest compressions, often referred to as "no-flow time," to improve return of spontaneous circulation. ...
Rubin Sarah - - 2013
High-flow humidified nasal cannula is often used to provide noninvasive respiratory support in children. The effect of high-flow humidified nasal cannula on effort of breathing in children has not been objectively studied, and the mechanism by which respiratory support is provided remains unclear. This study uses an objective measure of ...
Yadav Santosh K - - 2013
Obstructive sleep apnea (OSA) is a condition characterized by upper airway muscle atonia with continued diaphragmatic efforts, resulting in repeated airway obstructions, periods of intermittent hypoxia, large thoracic pressure changes, and substantial shifts in arterial pressure with breathing cessation and resumption. The hypoxic exposure and hemodynamic changes likely induce the ...
Ryan Clodagh M - - 2013
Both obstructive sleep apnoea (OSA) and impaired cerebrovascular reactivity (CVR) are associated with an increased risk of stroke. We therefore hypothesised that CVR would be decreased in OSA patients. Since OSA is associated with altered endothelial function and this dysfunction may in turn lead to impaired CVR, we further hypothesised ...
Lintermann Andreas - - 2013
The flow in the human nasal cavity is of great importance to understand rhinologic pathologies like impaired respiration or heating capabilities, a diminished sense of taste and smell, and the presence of dry mucous membranes. To numerically analyze this flow problem a highly efficient and scalable Thermal Lattice-BGK (TLBGK) solver ...
Paspala Asimina - - 2013
Bilateral vocal cord paralysis can produce severe airway obstruction, leading to acute respiratory failure. Discriminating the pathology of the upper airway from chronic obstructive diseases of the lower airways often presents a challenge for clinicians in the Emergency Department. To underlie the value of clinical examination and flow-volume loops in ...
Thorstensen Wenche Moe - - 2013
The Unified Airways hypothesis suggests an involvement of the upper airways in asthma. Critical parameters of the nasal airway can be quantified objectively with acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF). We aimed to investigate nasal airway patency in asthmatics compared to non-asthmatic controls. Nasal volume, cross sectional ...
Louis Bruno - - 2013
Exploring nasal flow contributes to better understanding of pathophysiological functions of nasal cavities. We combined the rhinomanometry measurements of 11 patients and computational fluid dynamics (CFD) simulations in 3 nasal airway models to dissect the complex mechanisms that determine nasal flow obstruction: spatial complexity and pressure-dependent deformability of nasal airways. ...
Hastie Annette T AT Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. - - 2013
Sputum eosinophil percentages are a strong predictor of airway inflammation and exacerbations and aid asthma management, whereas sputum neutrophil percentages indicate a different severe asthma phenotype that is potentially less responsive to TH2-targeted therapy. Variables, such as blood eosinophil counts, total IgE levels, fraction of exhaled nitric oxide (Feno) levels, ...
Laval Julie - - 2013
Inflammatory conditions can profoundly alter human neutrophils, a leukocyte subset generally viewed as terminally differentiated and catabolic. In cystic fibrosis (CF) patients, neutrophils recruited to CF airways show active exocytosis and sustained phosphorylation of prosurvival, metabolic pathways. Because the CF airway lumen is also characterized by high levels of free ...
Zhao Ran - - 2013
BACKGROUND: The upper airway has powerful heat-absorbing ability, in which the blood circulation may play an important role. OBJECTIVE: This study aimed to explore the circulational heat-dissipating ability, and to investigate the contribution of blood circulation to the heat-absorbing ability of upper airway. METHODS: 18 adult, male Beagle dogs were ...
Petersen Trine Puggaard - - 2013
A safe, practical and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.
Walter Robert N - - 2013
The objective of this clinical vignette is to explore whether changes in low filter settings for respiratory waveforms have a clinically significant effect on patient management of obstructive sleep apnea (OSA). This is a case report. We collected data from a continuous positive airway pressure (CPAP) titration polysomnogram (PSG) performed ...
Schleich Florence N - - 2013
ABSTRACT: BACKGROUND: Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed to identify predictors of sputum inflammatory phenotypes according to easily available clinical characteristics. METHODS: This retrospective study was conducted in 508 asthmatics with successful sputum induction recruited from ...
Cattoni Ilaria - - 2013
ABSTRACT Exhaled nitric oxide (FeNO50), a biomarker of airway inflammation, is affected by changes in airway calibre. Whether lower FeNO50 levels during bronchoconstriction is only an artifact due to the strong flow-dependence of this parameter is controversial.We aimed to evaluate the dynamics of airway and alveolar NO during acute bronchoconstriction ...
Ullmann N N Respiratory Paediatrics, Royal Brompton Hospital London and NHLI Imperial College London, London, - - 2013
The inflammatory phenotypes of severe asthma in adults may be reflected in peripheral blood. If this were true in children with severe therapy-resistant asthma (STRA), invasive tests could be avoided. At the moment there is no conclusive evidence in children. All patients underwent blood tests, exhaled nitric oxide (FeNO), sputum ...
Kim Hyun-Jun HJ Department of Obstetrics & Gynecology, Konkuk University, Chungju 308-701, Republic of - - 2013
The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation (%), and heart rate (beats/min) in normal ...
Ward Jeffrey J - - 2013
The nasal cannula has been a commonly used patient interface to provide supplemental oxygen since its introduction in the 1940s. Traditionally, it has been categorized as a low-flow device and capable of delivering a 0.4 F(IO(2)) with flows up to 6 L/min to adults with normal minute ventilation. However, there ...
Rahman Adeeb H - - 2013
Multiparametric flow cytometry is a powerful technique that allows the quantification and characterization of heterogeneous populations of cells. Advances in flow cytometric instrumentation, software, and reagents are occurring at a rapid pace, and flow cytometric methods are increasingly being applied to better understand cellular responses associated with a diverse array ...
Akkök Ciğdem Akalın - - 2012
Blood components should be compatible both with the recipient and the donor in the ABO incompatible allogeneic stem cell transplantation setting. A patient with blood type A2 received peripheral blood stem cells from a blood type O donor. The patient was in critical condition due to treatment-related toxicity. He had ...
Sperling Or - - 2012
In a world of diminishing water reservoirs and a rising demand for food, the practice and development of water stress indicators and sensors are in rapid progress. The heat dissipation method, originally established by Granier, is herein applied and modified to enable sap flow measurements in date palm trees in ...
Ebihara Yasuhiro - - 2012
Red blood cell (RBC) transfusion is necessary for many patients with emergency or hematological disorders. However, to date the supply of RBCs remains labile and dependent on voluntary donations. In addition, the transmission of infectious disease via blood transfusion from unspecified donors remains a risk. Establishing a large quantity of ...
Fitzhugh Courtney D - - 2012
Peripheral blood stem cell (PBSC) infusions are associated with complications such as elevated blood pressure and decreased creatinine clearance. Patients with sickle cell disease experience similar manifestations, and some have postulated release of plasma-free hemoglobin with subsequent nitric oxide consumption as causative. We sought to evaluate whether the infusion of ...
Screnci Maria - - 2012
Umbilical cord blood (UCB) is a source of stem cells for allogeneic haematopoietic transplantation in paediatric and adult patients with haematological malignancies and other indications. Voluntary donation is the basis for the success of unrelated UCB transplantation programmes. In the last few years a growing number of private banks offer ...
Mortazavi Samira - - 2012
Background aims. Stem cells are commonly enumerated with bead-based methods in blood and marrow progenitor cell transplantation centers. We compared the International Society of Hematotherapy and Graft Engineering (ISHAGE) bead-based method with a true volumetric one that obviates the use of fluorescent beads for enumeration. Methods. From 31 samples, including ...
Avila M - - 2012
Turbulent transport of angular momentum is a necessary process to explain accretion in astrophysical disks. Although the hydrodynamic stability of disklike flows has been tested in experiments, results are contradictory and suggest either laminar or turbulent flow. Direct numerical simulations reported here show that currently investigated laboratory flows are hydrodynamically ...
Skene Loane - - 2012
Opponents of human embryo research have understandably welcomed pluripotent stem cells being derived from body cells including cells from umbilical cords after childbirth. The cord would otherwise be discarded and embryos are not destroyed. However, there are other ethical, legal and political issues in cord blood collection, whether for the ...
Lunde Marianne S H - - 2012
Postprandial physical activity may blunt the blood glucose response. In diabetes prone female immigrants only slow walking is regularly performed raising the question of whether also this type of physical activity can attenuate their post meal blood glucose elevation. Using a cross over design, 11 female Pakistani immigrants living in ...
1 2 3 4 5 6 7 8 9 10 >