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Sakazaki Sayaka S Division of Pediatric Cardiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, 350-8550, - - 2014
Hypoxia due to congenital heart diseases (CHDs) adversely affects brain development during the fetal period. Head circumference at birth is closely associated with neuropsychiatric development, and it is considerably smaller in newborns with hypoplastic left heart syndrome (HLHS) than in normal newborns. We performed simulation studies on newborns with CHD ...
Suwa Kenichiro K Division of Cardiology, Internal Medicine III, Hamamatsu University - - 2014
Background:The intra-left atrial (LA) blood flow from pulmonary veins (PVs) to the left ventricle (LV) changes under various conditions and might affect global cardiac function. By using phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging (4D-Flow), the intra-LA vortex formation was visualized and the factors affecting the intra-LA flow dynamics ...
Wei Xufeng X Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2014
Despite the significant contribution of the Fontan procedure to the therapy of complex congenital heart diseases, many patients progress to failure of their Fontan circulation. The use of ventricular assist devices (VADs) to provide circulatory support to these patients remains challenging. In the present study, a continuous axial-flow pump was ...
Midgett Madeline M Department of Biomedical Engineering and Knight Cardiovascular Institute, Center for Developmental Health, Oregon Health and Science University, 3303 SW Bond Avenue, CHH 13B, Portland, OR 97239, - - 2014
Altered blood flow during embryonic development has been shown to cause cardiac defects; however, the mechanisms by which the resulting haemodynamic forces trigger heart malformation are unclear. This study used heart outflow tract banding to alter normal haemodynamics in a chick embryo model at HH18 and characterized the immediate blood ...
Marom Gil G Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, - - 2014
The SynCardia total artificial heart (TAH) is the only Food and Drug Administration (FDA) approved device for replacing hearts in patients with congestive heart failure. It pumps blood via pneumatically driven diaphragms and controls the flow with mechanical valves. While it has been successfully implanted in more than 1300 patients, its ...
Kuan Yee Han YH a Department of Biomedical Engineering , National University of Singapore , - - 2014
The characterization of the bileaflet mechanical heart valves (BMHVs) hinge microflow fields is a crucial step in heart valve engineering. Earlier in vitro studies of BMHV hinge flow at the aorta position in idealized straight pipes have shown that the aortic sinus shapes and sizes may have a direct impact ...
Fleck Thilo T Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany, - - 2014
Propofol is a short-acting, intravenously administered hypnotic agent which is used in procedural sedation in children. Propofol is known to decrease systemic vascular resistance, arterial blood pressure and can lead to desaturations and decreased systemic perfusion in children with cardiac shunting. This may result in a reduction in cerebral blood ...
Abrams D D Division of Pulmonary, Allergy and Critical Care, Columbia University College of Physiciansand Surgeons, New York, New York, USA - - - 2014
Extracorporeal membrane oxygenation (ECMO) technology has undergone significant advancement in the last several years. These changes have led to more compact circuits that are increasingly efficient at gas exchange while decreasing the complication rates often associated with its use. The ability to remove carbon dioxide at relatively low flows has ...
Ramaswamy Sharan - - 2014
The ability to replicate physiological stress and hemodynamic conditions during in-vitro tissue development has been recognized as an essential aspect in the development of engineered heart valve tissues. Moreover, we have demonstrated that studies aiming to understand mechanical conditioning require separation of the major heart valve deformation loading modes: flow, ...
Hayakawa Akira A Department of Forensic Medicine, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Previous studies have reported that thyroglobulin (Tg) concentrations in heart blood are high in cases of asphyxia caused by neck compression such as hanging, strangulation, and throttling and in those with fatal traumatic brain injuries. However, even in cases without these findings presumed to increase the Tg concentration in the ...
Capron Thibaut T Aix-Marseille Université, UMR 7339, CNRS, CRMBM (Centre de Résonance Magnétique Biologique et Médicale), 13385, Marseille, - - 2014
Although arterial spin labeling (ASL) has become a routinely performed method in the rodent heart, its application to the human heart remains challenged by low tissue blood flow and cardiac and respiratory motion. We hypothesized that an alternative steady-pulsed ASL (spASL) method would provide more efficient perfusion signal averaging by ...
Zhou Shan S Shan Zhou, Ian Welsby, Department of Anesthesiology, Duke University Medical Center 3094, Durham, NC 27710, United - - 2014
ABO blood type is one of the most readily available laboratory tests, and serves as a vital determinant in blood transfusion and organ transplantation. The ABO antigens are expressed not only on red blood cell membranes, determining the compatibility of transfusion, but also on the surface of other human cells, ...
Fadel Bahaa M BM King Faisal Specialist Hospital & Research Center, Riyadh, Saudi - - 2014
The flow pattern in the hepatic veins (HVs) is dependent on the cardiac cycle and right heart hemodynamics and influenced by the respiratory cycle and the liver parenchyma. Most disease states that affect the right heart alter the HV Doppler in a manner independent of the respiratory cycle. Some diseases ...
Chasovskyi K K Perfusiology, Ukrainian Children's Cardiac Center, Kyiv, Ukraine - - 2014
This study evaluates the hemoglobin-oxygen relationship and tissue perfusion during cardiopulmonary bypass (CPB) in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components. We compared perioperative hematocrit (Hct), fetal hemoglobin (HbF), p50O2, pH, pCO2, serum lactate, duration of mechanical ventilation and intensive care unit (ICU) length ...
Punn Rajesh R All authors: Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital, Palo Alto, - - 2014
Currently, there are no established echocardiographic or hemodynamic predictors of mortality after weaning venoarterial extracorporeal membrane oxygenation in children. We wished to determine which measurements predict mortality. Over 3 years, we prospectively assessed six echo and six hemodynamic variables at 3-5 circuit rates while weaning extracorporeal membrane oxygenation flow. Hemodynamic ...
Salinas Manuel M Tissue Engineering, Mechanics, Imaging, and Materials Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL, - - 2014
Previous efforts in heart valve tissue engineering demonstrated that the combined effect of cyclic flexure and steady flow on bone marrow derived stem cell-seeded scaffolds resulted in significant increases in engineered collagen formation [Engelmayr et al. Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: Implications ...
Fadel Bahaa M BM King Faisal Specialist Hospital & Research Center, Riyadh, Saudi - - 2014
Doppler interrogation of blood flow in the hepatic veins (HVs) is a part of any comprehensive echocardiographic examination. Data derived from the HV Doppler provide a useful tool for the assessment of right heart function. Beyond its dependence on the cardiac cycle, right heart hemodynamics, and compliance of the liver ...
Ritman Erik L EL Mayo Clinic College of Medicine - - 2014
During WW2 Earl Wood was charged with elucidating the biomedical factors in acceleration-induced loss of consciousness (G-LOC) experienced by pilots in high performance aircraft. For this he developed devices for measurement and recording of blood pressure and tissue blood content. Those data lead to the design and fabrication of successful ...
Andrikopoulos Georgios K GK Sotirios P Gartaganis, Georgios K Andrikopoulos, Department of Ophthalmology, University of Patras Medical School, 26504 Patras, - - 2014
Pseudoexfoliation (PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery. Apart from the long-known intraocular manifestations, PEX deposits have been found in a variety of extraocular locations and they ...
Dietrich Ann-Christin AC Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476 Potsdam, Germany; Institute for Molecular Biology, Medizinische Hochschule Hannover, Carl-Neuberg Straße 1, 30625 Hannover, Germany; Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13125 Berlin, - - 2014
During heart development, the onset of heartbeat and blood flow coincides with a ballooning of the cardiac chambers. Here, we have used the zebrafish as a vertebrate model to characterize chamber ballooning morphogenesis of the endocardium, a specialized population of endothelial cells that line the interior of the heart. By ...
O'Brien K M KM University of Alaska Fairbanks, Institute of Arctic Biology, PO Box 757000, Fairbanks, AK 99775, USA. Electronic address: - - 2014
Creatine kinase (CK; EC 2.7.3.2) functions as a spatial and temporal energy buffer, dampening fluctuations in ATP levels as ATP supply and demand change. There are four CK isoforms in mammals, two cytosolic isoforms (muscle [M-CK] and brain [B-CK]), and two mitochondrial isoforms (ubiquitous [uMtCK] and sarcomeric [sMtCK]). Mammalian oxidative ...
Delorme Yann T YT School of Mechanical Engineering, Purdue University, Lafayette, IN, United - - 2014
Univentricular heart disease is the leading cause of death from any birth defect in the first year of life. Typically, patients have to undergo three open heart surgical procedures within the first few years of their lives to eventually directly connect the superior and inferior vena cavae to the left ...
Alizadeh Mansour M Department of Mechanical Engineering, Iran University of Science & Technology, Tehran, - - 2014
The purpose of this study is to investigate the hemodynamic parameters of blood flow in a balloon as a part of a new type of cardiac assist device named AVICENA, which is implanted into the descending aorta to improve the strength of pumping blood flow in a poor-performing left ventricle. ...
Tsounis Michael M Department of Otorhinolaryngology/Head and Neck Surgery (M.T.), Queen's Medical Centre, Nottingham, United - - 2014
The aim of this study was to ascertain the most reliable objective measurement for the assessment of nasal patency by investigating the relationship between peak nasal inspiratory flow, peak oral inspiratory flow, and the nasal patency index in relation to the patient's subjective perception regarding nasal obstruction. Prospective cohort study. ...
Kobayashi Yoshiki - - 2014
Objective: Most asthmatics have been found to have rhinosinusitis (RS). Patients with ethmoid sinusitis, in particular, often suffer from an impaired sense of smell; this is clinically important and necessitates concurrent treatment for both asthma and RS. As a rational therapeutic strategy, we focused on a fine particle HFA-134abeclomethasone dipropionate ...
Nobahar Mohammad Rezvan MR Department of Cardiac Anesthesia (Anesthesiology in Cardiac Surgery), Shahid Modares Hospital, Saadat Abad, Tehran, - - 2014
Acute normovolemic hemodilution (ANH) and preoperative autologous blood donation (PABD) have questionable efficacy, viral and bacterial infection risks, intermittent blood shortages as homeostasis problem, electrolyte and hemodynamic disturbances. In this cross sectional survey, we studied 70 patients undergoing open heart coronary artery bypass grafts [CABG] and different valvular replacement 1 ...
Ghezzi Chiara E CE Department of Mining and Materials Engineering, McGill University, Montreal, Quebec, Canada H3A - - 2014
Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airway smooth muscle cells. This ...
Zhao Kai K Monell Chemical Senses Center, Philadelphia, PA; Department of Otolaryngology, Thomas Jefferson University, Philadelphia, - - 2014
Nasal airflow is essential for the functioning of the human nose. Given individual variation in nasal anatomy, there is yet no consensus what constitutes normal nasal airflow patterns. We attempt to obtain such information that is essential to differentiate disease-related conditions. Computational fluid dynamics (CFD) simulated nasal airflow in 22 ...
Kirtsreesakul Virat V Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, - - 2014
Although nasal peak flow measurements have been proposed as a simple alternative method to assess nasal patency, which of nasal peak expiratory flow or nasal peak inspiratory flow (NPEF/NPIF) or the peak expiratory flow index or peak inspiratory flow index (PEFI/PIFI; the ratios between nasal and oral PEF or nasal ...
Hirose Kayo K Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate - - 2014
A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level ...
Wang Yong Y Department of Mechanical & Aerospace Engineering, University of California, Irvine, CA 92697, - - 2013
The fluid dynamical properties of the air flow in the upper airway (UA) are not fully understood at present due to the three-dimensional (3D) patient-specific complex geometry of the airway, flow transition from laminar to turbulent and flow-structure interaction during the breathing cycle. It is quite difficult at present to ...
Oreroğlu Ali Rıza AR Plastic Reconstructive and Aesthetic Surgery Department, Prof. Dr. A. İlhan Özdemir Giresun State Hospital, Atatürk Blvd. No. 323, 28100, Teyyaredüzü, Giresun, Turkey, - - 2013
The combination of dorsal nasal reconstruction and camouflage of surface irregularities is an important step in rhinoplasty. We hereby present our technique of delivering diced cartilage in combination with bone dust to the nasal dorsum using the patient's blood as a carrier. We advocate use of an autologous material (blood) ...
Miller Vincent J - - 2013
Traditionally, pausing chest compressions during airway management in a cardiac arrest has been the accepted norm. However, updated American Heart Association and the European Resuscitation Council guidelines for Advanced Cardiac Life Support emphasize reducing pauses in chest compressions, often referred to as "no-flow time," to improve return of spontaneous circulation. ...
Rubin Sarah - - 2013
High-flow humidified nasal cannula is often used to provide noninvasive respiratory support in children. The effect of high-flow humidified nasal cannula on effort of breathing in children has not been objectively studied, and the mechanism by which respiratory support is provided remains unclear. This study uses an objective measure of ...
Yadav Santosh K SK Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095, - - 2013
Obstructive sleep apnea (OSA) is a condition characterized by upper airway muscle atonia with continued diaphragmatic efforts, resulting in repeated airway obstructions, periods of intermittent hypoxia, large thoracic pressure changes, and substantial shifts in arterial pressure with breathing cessation and resumption. The hypoxic exposure and hemodynamic changes likely induce the ...
Ryan Clodagh M - - 2013
Both obstructive sleep apnoea (OSA) and impaired cerebrovascular reactivity (CVR) are associated with an increased risk of stroke. We therefore hypothesised that CVR would be decreased in OSA patients. Since OSA is associated with altered endothelial function and this dysfunction may in turn lead to impaired CVR, we further hypothesised ...
Lintermann Andreas - - 2013
The flow in the human nasal cavity is of great importance to understand rhinologic pathologies like impaired respiration or heating capabilities, a diminished sense of taste and smell, and the presence of dry mucous membranes. To numerically analyze this flow problem a highly efficient and scalable Thermal Lattice-BGK (TLBGK) solver ...
Paspala Asimina - - 2013
Bilateral vocal cord paralysis can produce severe airway obstruction, leading to acute respiratory failure. Discriminating the pathology of the upper airway from chronic obstructive diseases of the lower airways often presents a challenge for clinicians in the Emergency Department. To underlie the value of clinical examination and flow-volume loops in ...
Thorstensen Wenche Moe - - 2013
The Unified Airways hypothesis suggests an involvement of the upper airways in asthma. Critical parameters of the nasal airway can be quantified objectively with acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF). We aimed to investigate nasal airway patency in asthmatics compared to non-asthmatic controls. Nasal volume, cross sectional ...
Louis Bruno - - 2013
Exploring nasal flow contributes to better understanding of pathophysiological functions of nasal cavities. We combined the rhinomanometry measurements of 11 patients and computational fluid dynamics (CFD) simulations in 3 nasal airway models to dissect the complex mechanisms that determine nasal flow obstruction: spatial complexity and pressure-dependent deformability of nasal airways. ...
Hastie Annette T AT Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. - - 2013
Sputum eosinophil percentages are a strong predictor of airway inflammation and exacerbations and aid asthma management, whereas sputum neutrophil percentages indicate a different severe asthma phenotype that is potentially less responsive to TH2-targeted therapy. Variables, such as blood eosinophil counts, total IgE levels, fraction of exhaled nitric oxide (Feno) levels, ...
Laval Julie - - 2013
Inflammatory conditions can profoundly alter human neutrophils, a leukocyte subset generally viewed as terminally differentiated and catabolic. In cystic fibrosis (CF) patients, neutrophils recruited to CF airways show active exocytosis and sustained phosphorylation of prosurvival, metabolic pathways. Because the CF airway lumen is also characterized by high levels of free ...
Zhao Ran - - 2013
BACKGROUND: The upper airway has powerful heat-absorbing ability, in which the blood circulation may play an important role. OBJECTIVE: This study aimed to explore the circulational heat-dissipating ability, and to investigate the contribution of blood circulation to the heat-absorbing ability of upper airway. METHODS: 18 adult, male Beagle dogs were ...
Petersen Trine Puggaard - - 2013
A safe, practical and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.
Walter Robert N - - 2013
The objective of this clinical vignette is to explore whether changes in low filter settings for respiratory waveforms have a clinically significant effect on patient management of obstructive sleep apnea (OSA). This is a case report. We collected data from a continuous positive airway pressure (CPAP) titration polysomnogram (PSG) performed ...
Schleich Florence N - - 2013
ABSTRACT: BACKGROUND: Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed to identify predictors of sputum inflammatory phenotypes according to easily available clinical characteristics. METHODS: This retrospective study was conducted in 508 asthmatics with successful sputum induction recruited from ...
Cattoni Ilaria - - 2013
ABSTRACT Exhaled nitric oxide (FeNO50), a biomarker of airway inflammation, is affected by changes in airway calibre. Whether lower FeNO50 levels during bronchoconstriction is only an artifact due to the strong flow-dependence of this parameter is controversial.We aimed to evaluate the dynamics of airway and alveolar NO during acute bronchoconstriction ...
Ullmann N N Respiratory Paediatrics, Royal Brompton Hospital London and NHLI Imperial College London, London, - - 2013
The inflammatory phenotypes of severe asthma in adults may be reflected in peripheral blood. If this were true in children with severe therapy-resistant asthma (STRA), invasive tests could be avoided. At the moment there is no conclusive evidence in children. All patients underwent blood tests, exhaled nitric oxide (FeNO), sputum ...
Kim Hyun-Jun HJ Department of Obstetrics & Gynecology, Konkuk University, Chungju 308-701, Republic of - - 2013
The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation (%), and heart rate (beats/min) in normal ...
Ward Jeffrey J - - 2013
The nasal cannula has been a commonly used patient interface to provide supplemental oxygen since its introduction in the 1940s. Traditionally, it has been categorized as a low-flow device and capable of delivering a 0.4 F(IO(2)) with flows up to 6 L/min to adults with normal minute ventilation. However, there ...
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