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Maślanka K K Department of Immunohematology and Immunology of Transfusion Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, - - 2014
Post-transfusion reactions with dyspnoea (PTR) are major causes of morbidity and death after blood transfusion. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are most dangerous, while transfusion-associated dyspnoea (TAD) is a milder respiratory distress. We investigated blood components for immune and non-immune factors implicated in PTR. We ...
Ternström Lisa L Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
Transfusions of blood products can be lifesaving, but they are also associated with considerable risks and adverse effects, including immune response and infections. In cardiac surgery, transfusions have also been associated with increased mortality. We prospectively studied the effects of a structured programme to reduce transfusions and transfusion-associated costs in ...
Korets Ruslan R Columbia University, Department of Urology, New York, New York, United States, Columbia University Medical Center, Department of Urology , 161 Fort Washington Avenue , Herbert Irving Pavilion, 11th Floor , New York, New York, United States , 10032 , 212-305-5200 , 212-305-6813 ; - - 2014
Radical prostatectomy (RP) is associated with a high risk of intraoperative blood loss and subsequent blood transfusions. The shift in surgical technique from open radical prostatectomy (ORP) to robot-assisted radical prostatectomy (RARP) has resulted in lower operative blood loss, and reduced the need for transfusions. We analyzed the American College ...
Ejaz A A Departments of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Surgery, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, - - 2014
The decision to perform intraoperative blood transfusion is subject to a variety of clinical and laboratory factors. This study examined variation in haemoglobin (Hb) triggers and overall utilization of intraoperative blood transfusion, as well the impact of transfusion on perioperative outcomes. The study included all patients who underwent pancreatic, hepatic ...
Monnot Andrew D AD Cardno ChemRisk, LLC , San Francisco, CA , - - 2014
Abstract Chromium (Cr) (III) is a trace metal essential to human health and exposure typically occurs via the diet on a daily basis. Some groups of individuals, such as those consuming Cr(III) supplements or patients with Cr-containing implants, may have elevated blood Cr(III) concentrations. Although blood Cr(III) levels are thought ...
Hall Connie L - - 2014
Thrombotic microparticles released from cells and platelets in response to various stimuli are present in elevated numbers in various disease states that increase the risk for thrombotic events. In order to understand how particles of this size may localize in non-parallel flow regimes and increase thrombotic risk, a computational analysis ...
Cheung D D Department of Clinical Pathology, Sunnybrook Health Sciences - - 2014
Blood transfusion is a frequent medical intervention in hospitals. The benefits of, risks of and alternatives to blood transfusions are not consistently understood by patients. The objective of this study was to assess gaps in knowledge and comfort with the current process of consenting patients for blood transfusions. A standardised ...
Wang Wei W Department of Surgery, The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, - - 2014
The association between ABO blood group and the risk of esophageal carcinoma (EC) in previously published studies is uncertain and conflicting. The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case-control study and meta-analysis. We performed a population-based case-control ...
Schwab Pierre-Emmanuel PE Department of Orthopaedic Surgery, Cliniques Universitaires Saint Luc, Av. Hippocrate 10, 1200, Brussels, - - 2014
It is intuitive that blood loss is lower after unicompartmental knee arthroplasty (UKA), but the difference in potential blood loss between UKA and total knee arthroplasty (TKA) has not yet been studied extensively. The hypothesis of this study was that blood loss is less important in UKA and that it ...
Cinek Ondrej O Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, V Uvalu 84, 15006, Prague 5, Czech Republic, - - 2014
Only a few longitudinal molecular studies of enterovirus and islet autoimmunity have been reported, and positive results seem to be limited to Finland. We aimed to investigate an association between enterovirus RNA in blood and islet autoimmunity in the MIDIA study from Norway, a country which largely shares environmental and ...
Ahmed Zulfiqar Z Anesthesia Associates of Ann Arbor, Oakwood Hospital and Medical Center, Dearborn, MI, - - 2014
Necrotizing enterocolitis (NEC) is a common surgical emergency in premature infants and has high morbidity and mortality. Intraoperative treatment with fluid and transfusions may be difficult. We evaluated risk factors for patients who needed transfusion with packed red blood cells during surgery for necrotizing enterocolitis with bowel resection. Retrospective medical ...
El Kadmiri Nadia N Laboratory of Medical Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy, University Hassan II, 19 Rue Tarik Ibnou Ziad, B.P. 9154, Casablanca, 20000, Morocco, - - 2014
Several articles have highlighted the potential involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in neurodegeneration by showing a non-glycolytic activity of GAPDH specifically in the brains of subjects with Alzheimer's disease (AD). The novel aim of this study was to elucidate the critical role of GAPDH and its interaction with β-amyloid in ...
Levin Andrew E AE Immunetics, Inc., Boston, - - 2014
Transfusion-transmitted babesiosis caused by Babesia microti has emerged as a significant risk to the US blood supply. This study estimated the prevalence of B. microti antibodies in blood donors using an investigational enzyme immunoassay (EIA). A peptide-based EIA that detects both immunoglobulin (Ig)G and IgM antibodies to B. microti was developed and ...
McVerry Ferghal F Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United - - 2014
Computed tomography perfusion provides information on tissue viability according to proposed thresholds. We evaluated thresholds for ischemic core and tissue at risk and subsequently tested their accuracy in independent datasets. Tissue at risk was evaluated in patients with persistent arterial occlusions, and ischemic core thresholds in patients with recanalization and ...
Cordova Caio Maurício Mendes de CM Depto. de Ciências Farmacêuticas, Universidade de Blumenau, Blumenau, SC, - - 2014
Emergent diseases such as Hantavirus Cardio-pulmonary Syndrome (HCPS) are able to create a significant impact on human populations due to their seriousness and high fatality rate. Santa Catarina, located in the South of Brazil, is the leading state for HCPS with 267 reported cases from 1999 to 2011. We present ...
Alhan Canan C Department of Haematology, Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, The - - 2014
The estimation of survival of myelodysplastic syndromes (MDS) and risk of progression into acute myeloid leukaemia is challenging due to the heterogeneous clinical course. The most widely used prognostic scoring system (International Prognostic Scoring System [IPSS]) was recently revised (IPSS-R). The aim of this study was to investigate the prognostic ...
Klika Alison K AK Department of Orthopaedic Surgery, Cleveland Clinic A41, Cleveland, - - 2014
Perioperative blood loss leading to blood transfusion continues to be an issue for total knee arthroplasty (TKA) patients. The US Nationwide Inpatient Sample (NIS) was used to determine annual trends in allogenic blood transfusion rates, and effects of transfusion on in-hospital mortality, length of stay (LOS), costs, discharge disposition, and ...
Louis Elan D ED GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: - - 2014
Harmane (1-methyl-9H-pyrido[3,4-b]indole) (HA) is a potent neurotoxin that has been linked to two neurological diseases, essential tremor and Parkinson's disease. Blood harmane concentrations [HA] are elevated in patients with both diseases. An important question is whether HA is specifically linked with these diseases or alternatively, is a non-specific marker of ...
Sutton Jeffrey M JM Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, 234 Goodman Street, ML 0772, Cincinnati, OH, 45219, - - 2014
In this multi-institutional study of patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, we sought to identify factors associated with perioperative transfusion requirement as well as the association between blood transfusion and perioperative and oncologic outcomes. The surgical databases across six high-volume institutions were analyzed to identify patients who underwent pancreaticoduodenectomy for ...
Faddy Helen H Research and Development, Australian Red Cross Blood Service, Brisbane, QLD, Australia School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, - - 2014
Leptospirosis is one of the most common bacterial zoonoses worldwide, and clinical manifestations range from asymptomatic infection to acute febrile illness, multi-organ failure and death. Asymptomatic, acute bacteraemia in a blood donor provides a potential for transfusion-transmission, although only a single such case from India has been recorded. Human leptospirosis ...
Boutin Amélie - - 2014
Anemia is a prevalent condition in critically ill patients and red blood cell transfusions are frequent. Although transfusions at low hemoglobin levels have been shown to be associated with equivalent or better outcomes than higher hemoglobin thresholds, clinical equipoise persists in patients with traumatic brain injury considering their susceptibility to ...
Köhnke T T Department of Internal Medicine III, University of Munich, - - 2014
In acute myeloid leukemia (AML), assessment of minimal residual disease (MRD) by flow cytometry (flow MRD) after induction and consolidation therapy has been shown to provide independent prognostic information. However, data on the value of earlier flow MRD assessment is lacking. Therefore, the value of flow MRD detection was determined ...
Zhou Ya-Li YL Department of Haematology, 303rd Hospital of the People's Liberation Army, Nanning, Guangxi, - - 2014
Splenectomy is reported to increase the haemoglobin level in patients with haemoglobin H Constant Spring (HbH CS) disease; however, its impact on iron burden and the underlying mechanism remains unclear. From March through to May 2013, a total of 50 adults with HbH CS disease (25 cases splenectomised and 25 ...
Vetter Thomas R TR From the Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, - - 2014
Although blood transfusion is a common therapeutic intervention and a mainstay of treating surgical blood loss, it may be perceived by patients and their physicians as having associated risk of adverse events. Practicing patient-centered care necessitates that clinicians have an understanding of an individual patient's perceptions of transfusion practice and ...
Mackenzie Colin F CF From the Shock Trauma Anesthesiology Research Center (C.F.M., Y.W., P.F.H., G.H., L.G.S.), and Charles McMathias, National Study Center for Trauma and EMS, Shock Trauma Center (C.F.M.), Departments of Anesthesiology (C.F.M., P.F.H., G.H.), Physiology (C.F.M.), Epidemiology (H.H.C.), Medicine (L.G.S.), and Surgery (S.S.), School of Medicine, and Departments of Electrical Engineering (S.-Y.C.), Computer Science, University of Maryland; USAF C-STARS Baltimore (S.S.), - - 2014
Prediction of blood transfusion needs and mortality for trauma patients in near real time is an unrealized goal. We hypothesized that analysis of pulse oximeter signals could predict blood transfusion and mortality as accurately as conventional vital signs (VSs). Continuous VS data were recorded for direct admission trauma patients with ...
Levine Brett Russell BR From Rush University Medical Center, Chicago, IL (Dr. Levine, Dr. Haughom, Dr. Hellman, and Dr. Frank), and the University of Rochester Medical Center, Department of Orthopaedics and Rehabilitation, Rochester, NY (Dr. - - 2014
Perioperative blood loss during total knee arthroplasty can be significant, with magnitudes typically ranging from 300 mL to 1 L, with occasional reports of up to 2 L. The resultant anemia can lead to severe complications, such as higher rates of postoperative infection, slower physical recovery, increased length of hospital ...
Rasambainarivo Fidisoa T - - 2014
Evaluation of the health, prevalence, and incidence of diseases in wild populations is a critical component of wildlife management. In addition, the establishment of reference physiologic parameters can Verreaux's sifaka (Propithecus verreauxi) from Kirindy Mitea National Park, Madagascar, during two field captures incontribute to the assessment of population risks. Complete ...
Leoyklang Petcharat P Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, - - 2014
The exact pathomechanism of GNE myopathy remains elusive, but likely involves aberrant sialylation. We explored sialylation status of blood-based glycans as potential disease markers. We employed immunoblotting, lectin histochemistry and mass spectrometry. GNE myopathy muscle showed hyposialylation of predominantly O-linked glycans. The O-linked glycome of patients' plasma compared with controls ...
Yeh Yin-Ting YT Micro & Nano Integrated Biosystem (MINIBio) Laboratory, Pennsylvania State University, N-238 Millennium Science Complex, University Park, PA, 16802, - - 2014
Each year, outbreaks of viral infections cause illness, disability, death, and economic loss. As learned from past incidents, the detrimental impact grows exponentially without effective quarantine. Therefore, rapid on-site detection and analysis are highly desired. In addition, for high-risk areas of viral contamination, close monitoring should be provided during the ...
Xing Yingqi Y Department of Neurology, the First Norman Bethune Hospital of Jilin University, Changchun, 130021, - - 2014
Previous studies have identified a diverse set of predisposing factors for the occurrence of hemorrhagic transformation (HT), but the independent clinical predictors of HT after intraarterial thrombolysis have not been determined. In this retrospective study, we investigated the characteristics of patients with or without HT who had received intra-arterial thrombolysis ...
Clevenger Ben B Ben Clevenger, Susan V Mallett, Department of Anaesthesia, Royal Free NHS Foundation Trust, London NW3 2QG, United - - 2014
There is wide variation in the management of coagulation and blood transfusion practice in liver transplantation. The use of blood products intraoperatively is declining and transfusion free transplantations take place ever more frequently. Allogenic blood products have been shown to increase morbidity and mortality. Primary haemostasis, coagulation and fibrinolysis are ...
Agossa Fiacre R - - 2014
An investigation carried out in Benin has shown that, in some areas close to rivers where density of mosquitoes is high, long-lasting, insecticidal bed nets (LLINs) are permanently used. In such areas, LLINs are washed every month. Based on this situation, the 20-wash minimum efficacy advised by the manufacturers would ...
Patel Sunil V SV London Health Sciences Centre, London, Ontario, Canada. Electronic address: - - 2014
A previous meta-analysis has found an association between red blood cell (RBC) transfusions and mortality in critically ill patients, but no review has focused on the trauma population only. To determine the association between RBC transfusion and mortality in the trauma population, with secondary outcomes of multiorgan failure (MOF) and ...
Løvendorf Marianne B MB Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark; LEO Pharma A/S, Industriparken 55, 2750 Ballerup, Denmark. Electronic address: - - 2014
Psoriasis is a systemic inflammatory skin disease. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that recently have been found in the blood to be relevant as disease biomarkers. We aimed to explore miRNAs potential as blood biomarkers for psoriasis. Using microarray and quantitative real-time PCR we measured ...
Breau Rodney H RH Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; The Ottawa Hospital, Ottawa, Ontario, Canada; University of Ottawa, Ottawa, Ontario, Canada. Electronic address: - - 2014
Pelvic vasculature is complex and inconsistent while pelvic bones impede access to pelvic organs. These anatomical characteristics render pelvic surgery inherently difficult, and some of these procedures are frequently associated with blood loss that necessitates blood transfusion. The aim of this study was to review the literature on the use ...
Hendrickson Jeanne E JE Yale University School of Medicine, New Haven, - - 2014
Hemolytic transfusion reactions due to red blood cell (RBC) alloantibodies are a leading cause of transfusion-associated death. In addition to reported deaths, RBC alloantibodies also cause significant morbidity in the form of delayed hemolytic transfusion reactions. These alloantibodies may also cause morbidity in the form of anemia, with compatible RBC ...
Imaeda Daisuke D Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, - - 2014
We have previously demonstrated that Baikal seals (Pusa sibirica) are still being exposed to polychlorinated biphenyls (PCBs), and the population is at risk. In the present study, we measured the residue levels of PCBs and their hydroxylated metabolites (OH-PCBs) in the blood of Baikal seals and assessed the impact of ...
Hâţu G G Iuliu Haţieganu University of Medicine and Pharmacy, Epidemiology and Primary Health Care Department, 8th Victor Babes Street, 400012 Cluj-Napoca, Romania. Electronic address: - - 2014
Blood products safety is based on different criteria including the selection of blood donors. Blood donors referred to Cluj County (Romania) Blood Transfusion Centre in January-March 2012 completed a self-administered questionnaire and were examined by a physician. Data collected from first-time and repeat donors were compared for possible risk factors ...
Willett Laura Rees LR Division of Education, Rutgers Robert Wood Johnson Medical School, 1 RWJ Place, MEB-486, New Brunswick, NJ 08903, USA. Electronic address: - - 2014
Anemia is extremely common following hip fracture. Consistent data from randomized trials show that transfusion of less blood, with a transfusion threshold around 8 g/dL hemoglobin concentration, is preferable to a traditional threshold of 10 g/dL. Adoption of a lower threshold leads to at least equivalent clinical outcomes, with much less exposure ...
Thomas W W Haematology Department, Royal Devon & Exeter NHS Foundation Trust, Exeter, - - 2014
The aim of this study was to evaluate the introduction of two-sample policy for transfusion at our hospital and reduction of the risk of ABO incompatible transfusion. ABO incompatible transfusion can be a fatal but avoidable event. Wrong blood in tube is a cause of ABO incompatible transfusion and there ...
Remuzzi Andrea A 2 Engineering Department, University of Bergamo, Dalmine (BG) - - - 2014
The creation and management of an autologous arteriovenous fistula (AVF) as vascular access (VA) for hemodialysis patients is still a critical procedure. The placement of a functional and long-lasting VA derives from adequate planning of the surgical procedure based on physical examination, vascular mapping and selection of the best modality ...
Humphreys Ruth E RE Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, - - 2014
Given the prevalence of cardiovascular disease (CVD), early detection is crucial. Although traditional cardiovascular risk factors relate to future CVD, the predictive value of these risk factors can be relatively limited. Contemporary scientific attention has focused on alternative direct measures of arterial function. Based on the ability of the endothelium ...
Salvin Hannah E HE Iron Taskforce, The Australian Red Cross Blood Service, Adelaide, SA, - - 2014
Iron deficiency (ID) is an important consequence of blood donation. The epidemiology of this problem in the blood donor population was therefore studied to enable appropriate targeting of potential solutions to donor ID. A nationally representative, cluster-based cross-sectional study of Australian blood donors was performed. Donors were eligible for inclusion ...
Bou Monsef Jad J Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 - - 2014
The steady rise in demand for total hip arthroplasty constitutes a significant and increasing burden on health care resources. The biggest contributors to the total cost of hip replacement procedures other than the price of the implant are hospital stay and postoperative rehabilitation. Blood management is one of the most ...
Pauwels Nele S NS Belgian Red Cross-Flanders, Mechelen, Belgium. Electronic address: - - 2014
Blood services are reliant upon healthy blood donors to provide a safe and adequate supply of blood products. Inappropriate variables contained within blood donor exclusion criteria can defer potentially appropriate donors. The aim of this systematic review was to examine the effect of low pre-donation blood pressure, as compared with ...
Akyurekli Celine C Blood and Marrow Transplant Program, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, - - 2014
How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear. After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units. Non-Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing ...
Custer Brian B Blood Systems Research Institute, San Francisco, - - 2014
Donation eligibility is based on hemoglobin (Hb) level among other factors. This study assesses factors that influence Hb levels among first-time (FT) donors returning for a second donation. Allogeneic FT donors who successfully donated a red blood cell (RBC)-containing donation on their index presentation and returned to donate at least ...
Wilker Elissa H EH Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts. Electronic address: - - 2014
Long-term exposure to ambient air pollution has been associated with cardiovascular morbidity and mortality. Impaired vascular responses may, in part, explain these findings, but the association of such long-term exposure with measures of both conduit artery and microvascular function has not been widely reported. We evaluated the association between residential ...
Zlatar Zvinka Z ZZ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, - - 2014
Resting cerebral blood flow (CBF) decreases with age; however regulatory increases in hippocampal CBF have been associated with genetic risk (Apolipoprotein E [APOE] ε4 carriers) for Alzheimer's disease (AD). Although physical activity exerts beneficial effects on CBF in healthy elderly, the effects of sedentary behaviors on CBF remain unknown. We ...
Roulland Sandrine S Sandrine Roulland, Ester Morgado, Stéphanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unités Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Françoise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epidémiologie et Santé des Populations, Villejuif; Pietro Ferrari and Isabelle Romieu, International Agency for Research on Cancer, Lyon; Gilles Salles, Hospices Civils de Lyon, Université de Lyon, UMR CNRS 5239, Pierre Bénite, France; Rachel S. Kelly, Petra H.M. Peeters, Roel Vermeulen, Elio Riboli, and Paolo Vineis, School of Public Health, Imperial College London, London; Kay-Tee Khaw, University of Cambridge; Nick Wareham, Institute of Metabolic Science, Cambridge; Timothy J. Key and Ruth C. Travis, University of Oxford, Oxford, United Kingdom; Domenico Palli, Istituto per lo Studio e la Prevenzione Oncologica, Florence; Valeria Pala, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan; Rosario Tumino, "Civile-M.P. Arezzo" Hospital, Ragusa; Salvatore Panico, Federico II University, Naples; Carlotta Sacerdote, Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica-Piemonte, Torino, Italy; José R. Quirós, Public Health and Health Planning Directorate, Asturias; Carlos A. Gonzáles, Catalan Institute of Oncology, Barcelona; Maria-José Sánchez, Andalusian School of Public Health and Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Granada; Miren Dorronsoro, Basque Regional Health Department and CIBERESP Biodonostia, San Sebastian; Carmen Navarro, Murcia Regional Health Council, Universidad de Murcia, and CIBERESP, Murcia; Aurelio Barricarte, Navarre Public Health Institute and CIBERESP, Pamplona, - - 2014
The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in ...
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