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Willett Laura Rees LR Division of Education, Rutgers Robert Wood Johnson Medical School, 1 RWJ Place, MEB-486, New Brunswick, NJ 08903, USA. Electronic address: - - 2014
Anemia is extremely common following hip fracture. Consistent data from randomized trials show that transfusion of less blood, with a transfusion threshold around 8 g/dL hemoglobin concentration, is preferable to a traditional threshold of 10 g/dL. Adoption of a lower threshold leads to at least equivalent clinical outcomes, with much less exposure ...
Humphreys Ruth E RE Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, - - 2014
Given the prevalence of cardiovascular disease (CVD), early detection is crucial. Although traditional cardiovascular risk factors relate to future CVD, the predictive value of these risk factors can be relatively limited. Contemporary scientific attention has focused on alternative direct measures of arterial function. Based on the ability of the endothelium ...
Salvin Hannah E HE Iron Taskforce, The Australian Red Cross Blood Service, Adelaide, SA, - - 2014
Iron deficiency (ID) is an important consequence of blood donation. The epidemiology of this problem in the blood donor population was therefore studied to enable appropriate targeting of potential solutions to donor ID. A nationally representative, cluster-based cross-sectional study of Australian blood donors was performed. Donors were eligible for inclusion ...
Akyurekli Celine C Blood and Marrow Transplant Program, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, - - 2014
How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear. After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units. Non-Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing ...
Custer Brian B Blood Systems Research Institute, San Francisco, - - 2014
Donation eligibility is based on hemoglobin (Hb) level among other factors. This study assesses factors that influence Hb levels among first-time (FT) donors returning for a second donation. Allogeneic FT donors who successfully donated a red blood cell (RBC)-containing donation on their index presentation and returned to donate at least ...
Roulland Sandrine S B.N. supported by grants from Medimmune, Fondation de France (Grant No. 2010-15034), Association pour la Recherche sur le Cancer (Grant No. ARC#20101201415), and France Lymphome Espoir Association and by institutional grants from Institut National de la Santé et de la Recherche Médicale (INSERM) and Centre National de la Recherche Scientifique. S.S. supported by fellowship from French Ministry of Research and Fondation pour la Recherche Medicale. EPIC study supported by Europe Against Cancer Program of European Commission; Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund of Spanish Ministry of Health; Spanish regional governments of Andalusia, Asturias, Basque, Murcia, and Navarra; Catalan Institute of Oncology; Instituto de Salud Carlos III of Spanish Ministry of Health (Red Temática de Investigación Cooperativa en Cáncer Grant No. DR06/0020); Cancer Research United Kingdom; Medical Research Council United Kingdom; Hellenic Health Foundation; Italian Association for Research on Cancer; Italian National Research Council, Fondazione Istituto Banco Napoli; Compagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports, Netherlands Cancer Registry, LK Research Fund, Dutch Prevention Funds, Dutch Zorg Onderzoek Nederland, World Cancer Research Fund, and Statistics Netherlands; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Västerbotten, Sweden; Norwegian Cancer Society; Research Council of Norway; French League Against Cancer; INSERM; Mutuelle Générale de l'Education Nationale; 3M (France); Gustave Roussy Institute; and General Councils of - - 2014
The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in ...
Zlatar Zvinka Z ZZ Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, - - 2014
Resting cerebral blood flow (CBF) decreases with age; however regulatory increases in hippocampal CBF have been associated with genetic risk (Apolipoprotein E [APOE] ε4 carriers) for Alzheimer's disease (AD). Although physical activity exerts beneficial effects on CBF in healthy elderly, the effects of sedentary behaviors on CBF remain unknown. We ...
Kitau Jovin - - 2014
Long-lasting insecticide treated blankets (LLIBs) may provide additional protection against malaria where use of long lasting insecticidal nets (LLIN) is low or impractical such as in disaster or emergency situations. Initial efficacy testing of a new candidate LLIB was carried out at LSHTM and KCMUCo, before and after washing, in ...
Tripolino Cesare C Dipartimento di Medicina Sperimentale e Clinica, "Magna Græcia" University, Catanzaro, - - 2014
Peripheral artery occlusive disease (PAOD) is associated with increased cardiovascular risk (CVR). Recently it has been reported that also the increased stiffness of lower limb arteries is associated with increased CVR. In particular, subjects with poorly compressible arteries (PCA) appear to have a CVR even higher than that of subjects ...
Song Howard K HK Division of Cardiothoracic Surgery, Oregon Health & Science University, Portland, Oregon. Electronic address: - - 2014
Perioperative red blood cell transfusion is associated with adverse outcomes after cardiac operations. Although restrictive transfusion protocols have been developed, their safety and efficacy are not well demonstrated, and considerable variation in transfusion practice persists. We report our experience with a restrictive transfusion protocol. We analyzed the outcomes in 409 ...
Winfield Laramie S LS Steinbeck Country Equine Clinic, 15881 Toro Hills Ave, Salinas, CA - - 2014
Case Description-A 23-year-old Thoroughbred mare was evaluated because of a coagulopathy causing hemoperitoneum, hematomas, and signs of blood loss-induced anemia. Clinical Findings-The mare had tachycardia, pallor, hypoperfusion, and a large mass in the right flank. The mass was further characterized ultrasonographically as an extensive hematoma in the body wall with ...
Alotaibi Ghazi S - - 2014
Background Sickle cell disease (SCD) is associated with perioperative vascular (SCD-related) and non-vascular complications. To minimize perioperative complications during elective surgery, either exchange blood transfusion or simple blood transfusion can be used. We systematically reviewed the literature and meta-analyzed randomized and observational trials comparing exchange transfusion to simple transfusion, as ...
Junge Kristin M KM Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Environmental Immunology, Germany; McMaster University, Division of Clinical Immunology and Allergy, Hamilton, ON, Canada. Electronic address: - - 2014
Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. In a sub-cohort of the LINA study cord ...
Park Sung Jun SJ Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
The establishment of reliable markers to monitor adequate tissue perfusion during extracorporeal life support is clinically important to improve outcomes. We evaluated 115 consecutive adult patients (aged 61.7 ± 13.4 years, 59 female patients) undergoing extracorporeal life support to manage low cardiac output syndrome after major cardiac surgery. The blood ...
Stonemetz Jerry L JL Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, - - 2014
Blood utilization has become an important outcome measure for surgical patients because of the recognized risks and costs associated with transfusion. However, comparisons of blood utilization between providers or institutions are difficult, because there is no standard method for risk adjustment when assessing surgical blood requirements. We examined whether accepted ...
Aramaki Osamu O Department of Digestive Surgery, Nihon University School of Medicine, 30-1 Ohyaguchikami-machi, Itabashi-ku, Tokyo, 173-8610, - - 2014
The correlation between blood loss and the risk of postoperative complications was unclear in patients undergoing resection of hepatocellular carcinoma (HCC). We studied 539 patients who had resection of HCC. Postoperative complications were recorded according to the modified Clavien-Dindo classification. Variables were compared between patients with grade III to V ...
Appassakij Hatsadee H Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, - - 2014
Asymptomatic Chikungunya fever (CHIKF)-viremic blood donors could be a potential threat of spreading the disease unwittingly through contaminated blood transfusions. The relatively low prevalence of Chikungunya virus antibodies in the population and the records of more than 9000 suspected CHIKF cases raised concern about the potential transfusion-associated CHIKF during the ...
Holowaychuk Marie K MK Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, - - 2014
Objective-To determine whether the number, volume, or age of transfused packed RBC units; volume of other blood products; or pretransfusion PCV was a risk factor for transfusion-associated complications or nonsurvival in dogs. Design-Retrospective case series. Animals-211 client-owned dogs receiving stored packed RBC transfusions. Procedures-Information collected or calculated from the medical ...
Demirtas Sinan S Department of Cardiovascular Surgery, Medical School of Dicle University, Diyarbakir, - - 2014
ObjectiveThe aim of the present study is to evaluate whether blood count parameters differ according to the stages of Fontaine's classification and to investigate the relationship between hemogram parameters and the severity of the disease.MethodEighty-two peripheral arterial disease patients were examined prospectively. Patients were classified according to the Fontaine classification ...
Figuero Elena E Oral Research Laboratory, Faculty of Odontology, University Complutense, Madrid, - - 2014
Background: The aim of this investigation was to quantify periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Campylobacter rectus and Tannerella forsythia) in vascular, blood and subgingival samples. As secondary objective, two molecular bacterial identification methods [nested-polimerase chain reaction (PCR) and quantitative PCR (qPCR)] were compared. Methods: Seventy consecutive patients provided a ...
Cywinski Jacek B JB From the Departments of *General Anesthesiology and Transplant Center, †Quantitative Health Sciences, and ‡Hepato-pancreato-biliary and Transplant Surgery, Cleveland Clinic, Cleveland, - - 2014
Predicting blood product transfusion requirements during orthotopic liver transplantation (OLT) remains difficult. Our primary aim in this study was to determine which patient variables best predict recipient risk for large blood transfusion requirements during OLT. The secondary aim was to determine whether the amount of blood products transfused during OLT ...
Klatte Tobias T Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, - - 2014
ABO blood type is an inherited characteristic that has been associated with the prognosis of several malignancies, but there is little evidence in urothelial carcinoma of the bladder (UCB). The purpose of this study was to evaluate the effect of ABO blood type on mortality in patients with UCB treated ...
Ely Craig R CR Alaska Science Center, U.S. Geological Survey, 4210 University Drive, Anchorage, AK, 99508, USA, - - 2014
Tundra swans (Cygnus columbianus) like many waterfowl species are susceptible to lead (Pb) poisoning, and Pb-induced mortality has been reported from many areas of their wintering range. Little is known however about Pb levels throughout the annual cycle of tundra swans, especially during summer when birds are on remote northern ...
Lu Jun J Intensive care unit, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, - - 2014
Severe acute pancreatitis is a life-threatening disease. Patients with peripancreatic necrotic infection often require surgical removal of necrotic infected tissue and a wide debridement will cause blood loss and worsen the condition. To assess whether treatment with NovoSeven, a recombinant activated FVII (rFVIIa), could improve coagulation function and therefore reduce ...
Rogers Natasha M NM Vascular Medicine Institute; Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA - - 2014
Cardiovascular homeostasis and health is maintained through the balanced interactions of cardiac generated blood flow and cross-talk between the cellular components that comprise blood vessels. Central to this cross-talk is endothelial generated nitric oxide (NO) that stimulates relaxation of the contractile vascular smooth muscle (VSMC) layer of blood vessels. In ...
Monneret Guillaume G Hospices Civils de Lyon, Immunology Laboratory, Hôpital E, Herriot, 5 place d'Arsonval, 69437, Lyon, cedex 03, France. - - 2014
The best marker for the monitoring of immune alterations in critically ill patients (sepsis, trauma, pancreatitis, surgery, burns) so far remains decreased HLA-DR expression on monocytes measured by flow cytometry as it regularly provides valuable information in terms of mortality prediction or evaluation of risk for secondary infections. As shown ...
Chahine Lama M - - 2014
There is a pressing need for biomarkers to diagnose Parkinson's disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers - defined here as surrogate indicators of physiological or pathophysiological states - but blood has the advantage of being minimally invasive ...
Kumar Naresh N National University Health System, Singapore, Singapore. Electronic address: - - 2014
Metastatic spine tumour surgery (MSTS) and metastatic musculoskeletal tumour surgery (MMTS) are associated with substantial blood loss. Allogeneic blood transfusion is the present method used to replenish this blood. Intraoperative cell salvage (IOCS) is a viable alternative, but is contraindicated in tumour surgery because of the risk of tumour dissemination. ...
Jones Allison R AR RICH Heart Program, University of Kentucky College of Nursing (Dr Frazier), University of Kentucky College of Nursing (Ms Jones), - - 2014
Hemorrhage is a preventable cause of death among patients with trauma, and management often includes transfusion, either whole blood or a combination of blood components (packed red blood cells, platelets, fresh frozen plasma). We used the 2009 National Trauma Data Bank data set to evaluate the relationship between transfusion type ...
Goodall E E Operating Department, Glasgow Caledonian University. - - 2014
Transfusion associated circulatory overload (TACO) is a serious but under-recognised complication of blood transfusion. While the exact incidence rate is unknown the associated morbidity and mortality make this a transfusion reaction worthy of attention. This article provides details of a critical incident involving TACO followed by a literature review and ...
Danninger Thomas T 0000-0002-0933-5312 Department of Anesthesiology, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, - - 2014
Background. Various studies have raised concern of worse outcomes in patients receiving blood transfusions perioperatively compared to those who do not. In this study we attempted to determine the proportion of perioperative complications in the orthopedic population attributable to the use of a blood transfusion. Methods. Data from 400 hospitals ...
Eboumbou Moukoko Carole Else CE Department of Biological Sciences, Faculty of medicine and pharmaceutical sciences, University of Douala, BP 2701 Douala, Cameroon. - - 2014
Transfusion-transmissible infections (TTIs) pose a major health risk in Cameroon given the high prevalence of such pathogens and increased demands for blood donations in the local communities. This study aims at establishing the prevalence of commonly encountered TTIs among blood donors and transfusion-related complications among recipients in an urban center ...
Urbanova Barbora B Department of Neurology, 2nd Faculty of Medicine, Motol University Hospital, Charles University , Prague , Czech - - 2014
There has been a growing interest in vascular impairment associated with Alzheimer's disease (AD). This interest was stimulated by the findings of higher incidence of vascular risk factors in AD. Signs of vascular impairment were investigated notably in the field of imaging methods. Our aim was to explore ultrasonographic studies ...
Olszewski Adam - - 2014
Minimisation of blood transmitted diseases is a basic element of all blood transfusion strategies. Civilian health service standards used in peacetime may be difficult to implement in a battlefield. The risk of blood-borne diseases depends on the applied donor qualification procedures and the epidemiological situation in the areas of military ...
Damiens David D Université catholique de Louvain, Earth and Life Institute, Biodiversity Research Centre, Louvain-la-Neuve, Belgium; Insect Pest Control Laboratory, International Atomic Energy Agency, Vienna, - - 2014
When accidentally introduced in a new location, a species does not necessarily readily become invasive, but it usually needs several years to adapt to its new environment. In 2009, a national mosquito survey (MODIRISK) reported the introduction and possible establishment of an invasive mosquito species, Aedes j. japonicus, in Belgium. ...
Cheng Lesley L Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia ; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, - - 2014
microRNA (miRNA) are small non-coding RNA species that are transcriptionally processed in the host cell and released extracellularly into the bloodstream. Normally involved in post-transcriptional gene silencing, the deregulation of miRNA has been shown to influence pathogenesis of a number of diseases. Next-generation deep sequencing (NGS) has provided the ability ...
Sarkari Bahador B Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. - - 2014
Toxoplasma gondii is a protozoan parasite which can be transmitted to human through a variety of routes including blood transfusion. This cross sectional study aimed to evaluate the seroprevalence of Toxoplasma infection and related epidemiological features among healthy blood donors. A total of 1,480 healthy blood donors from five blood ...
Wang Jie J Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, - - 2014
Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2. However, some patients may be "resistant" to its effect. The resistance has close association with adverse cardiovascular outcomes and increased mortality, so that resolving the problem of aspirin resistance (AR) is ...
Santhanam Anand A Department of Radiation Oncology, University of California, Los - - 2014
The aim of this paper is to enable a simulation tool for cardiovascular blood flow in order to better understand normal and hemorrhage conditions. A second order partial differential model for cardiovascular blood flow is employed. The individual components of the model is represented as an RLC circuit representation. Injury ...
Vivekanantham Sayinthen S Faculty of Medicine, Imperial College London, London, - - 2014
A 55-year-old woman with a background of vascular disease presented with signs of bilateral limb ischaemia. Following elective axillobifemoral bypass and hospital discharge, accidental axillary trauma causing a chest wall haematoma, the patient underwent an emergency graft repair. Postextubation, she reported with absent sensation in her legs. Spinal cord infarction ...
Gálvez Jorge A JA Department of Anesthesiology & Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, - - 2013
Children are a vulnerable population in the operating room, and are particularly at risk of complications from unanticipated hemorrhage. The decision to prepare blood products prior to surgery varies depending on the personal experience of the clinician caring for the patient. We present the first application of a data visualization ...
Zhao-Yu Chen C Department of Orthopedics, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, People's Republic of - - 2013
The purpose of the study is to conduct a meta-analysis of randomized, controlled trials evaluating the efficacy and safety of intra-articular injection of tranexamic acid (TXA) for reducing blood loss and transfusion in patients undergoing total knee arthroplasty (TKA). A meta-analysis was conducted of RCTs published before March 2013, identified ...
David Mazer C C Department of Anesthesia, St Michael's Hospital, University of Toronto, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: - - 2013
Bleeding related to cardiac surgery is an important clinical problem. Perioperative anemia and transfusion of allogeneic blood products have both been associated with adverse outcome including mortality and major morbidity. Guidelines exist to help determine when the risks of anemia outweigh the risks of transfusion. Perioperative bleeding may be related ...
Ziemann Malte M Institute of Transfusion Medicine, University Hospital of Schleswig-Holstein, Lübeck, - - 2014
Traditionally, leukoreduction and selection of blood products from seronegative donors have been used as alternative strategies to reduce the risk of transfusion-transmitted cytomegalovirus infections (TT-CMV) in atrisk patients. After the introduction of universal leukoreduction for red blood cell and platelet concentrates in Germany, a controversy evolved as to whether the ...
Kilic Arman A Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, - - 2013
Although red blood cell (RBC) transfusions are frequently used in cardiac operations, an increasing amount of data has demonstrated deleterious consequences. Consequently, the appropriate use of this limited resource is unclear. In this review, we discuss the relationship between anemia and the outcomes of cardiac surgical procedures, the risks associated ...
Zhu Si-Hai SH Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University , Nanjing , - - 2013
Abstract Introduction. Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with a higher risk of POCD in aged patients following total hip replacement ...
Klatte Tobias T Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, - - 2013
ABO blood type is an established prognostic factor in several malignancies, but its role in urothelial carcinoma of the bladder (UCB) is largely unknown. The objective of this study was to determine whether ABO blood type is associated with outcomes after transurethral resection (TURB) of non-muscle-invasive UCB (NMIBC). We retrospectively ...
Chuang Wei-Lien WL Genzyme Corporation, a Sanofi Company, One Mountain Road, Framingham, MA 01701-9322, - - 2013
Niemann-Pick disease type B (NPD-B) is caused by a partial deficiency of acid sphingomyelinase activity and results in the accumulation of lysosomal sphingomyelin (SPM) predominantly in macrophages. Notably, SPM is not significantly elevated in the plasma, whole blood, or urine of NPD-B patients. Here, we show that the de-acylated form ...
Woo Janghee - - 2013
Flow cytometry offers great diagnostic opportunities in the vast majority of hematologic and oncologic diseases with multiple cellular and molecular information within an individual cell. We will discuss various applications of flow cytometry, particularly in hematology and oncology, in addition to general principles and limitations of flow cytometry. They include ...
Liu Jun - - 2013
A systematic review of randomized controlled trials was conducted to examine the efficacy of fibrin sealants for the reduction of postoperative blood loss and allogeneic red blood cell transfusion in total knee arthroplasty (TKA). Studies published through May 2013 were identified from PubMed, Embase, the Cochrane library, ScienceDirect, and other ...
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